-- dump date 20140619_144259 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272630000001 Replication initiator protein A; Region: RPA; pfam10134 272630000002 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272630000003 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272630000004 P-loop; other site 272630000005 Magnesium ion binding site [ion binding]; other site 272630000006 ParB-like nuclease domain; Region: ParBc; pfam02195 272630000007 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 272630000008 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 272630000009 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 272630000010 Helix-turn-helix domain; Region: HTH_37; pfam13744 272630000011 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272630000012 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272630000013 catalytic residues [active] 272630000014 catalytic nucleophile [active] 272630000015 Presynaptic Site I dimer interface [polypeptide binding]; other site 272630000016 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272630000017 Synaptic Flat tetramer interface [polypeptide binding]; other site 272630000018 Synaptic Site I dimer interface [polypeptide binding]; other site 272630000019 DNA binding site [nucleotide binding] 272630000020 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 272630000021 DNA-binding interface [nucleotide binding]; DNA binding site 272630000022 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 272630000023 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 272630000024 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 272630000025 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630000026 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 272630000027 putative homodimer interface [polypeptide binding]; other site 272630000028 putative homotetramer interface [polypeptide binding]; other site 272630000029 putative metal binding site [ion binding]; other site 272630000030 putative homodimer-homodimer interface [polypeptide binding]; other site 272630000031 putative allosteric switch controlling residues; other site 272630000032 H+ Antiporter protein; Region: 2A0121; TIGR00900 272630000033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630000034 putative substrate translocation pore; other site 272630000035 High-affinity nickel-transport protein; Region: NicO; cl00964 272630000036 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 272630000037 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 272630000038 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 272630000039 putative metal binding site [ion binding]; other site 272630000040 putative homodimer interface [polypeptide binding]; other site 272630000041 putative homotetramer interface [polypeptide binding]; other site 272630000042 putative homodimer-homodimer interface [polypeptide binding]; other site 272630000043 putative allosteric switch controlling residues; other site 272630000044 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 272630000045 MobA/MobL family; Region: MobA_MobL; pfam03389 272630000046 AAA domain; Region: AAA_30; pfam13604 272630000047 Family description; Region: UvrD_C_2; pfam13538 272630000048 RNA pol II promoter Fmp27 protein domain; Region: Fmp27_WPPW; pfam10359 272630000049 Autoinducer synthetase; Region: Autoind_synth; cl17404 272630000050 DnaA N-terminal domain; Region: DnaA_N; pfam11638 272630000051 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 272630000052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272630000053 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272630000054 DnaA box-binding interface [nucleotide binding]; other site 272630000055 DNA polymerase III subunit beta; Validated; Region: PRK05643 272630000056 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272630000057 putative DNA binding surface [nucleotide binding]; other site 272630000058 dimer interface [polypeptide binding]; other site 272630000059 beta-clamp/clamp loader binding surface; other site 272630000060 beta-clamp/translesion DNA polymerase binding surface; other site 272630000061 recombination protein F; Reviewed; Region: recF; PRK00064 272630000062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630000063 Walker A/P-loop; other site 272630000064 ATP binding site [chemical binding]; other site 272630000065 Q-loop/lid; other site 272630000066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630000067 ABC transporter signature motif; other site 272630000068 Walker B; other site 272630000069 D-loop; other site 272630000070 H-loop/switch region; other site 272630000071 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 272630000072 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 272630000073 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272630000074 ATP binding site [chemical binding]; other site 272630000075 putative Mg++ binding site [ion binding]; other site 272630000076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630000077 nucleotide binding region [chemical binding]; other site 272630000078 ATP-binding site [chemical binding]; other site 272630000079 RQC domain; Region: RQC; pfam09382 272630000080 HRDC domain; Region: HRDC; pfam00570 272630000081 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 272630000082 AAA domain; Region: AAA_30; pfam13604 272630000083 Family description; Region: UvrD_C_2; pfam13538 272630000084 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 272630000085 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 272630000086 dimerization interface [polypeptide binding]; other site 272630000087 ATP binding site [chemical binding]; other site 272630000088 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 272630000089 dimerization interface [polypeptide binding]; other site 272630000090 ATP binding site [chemical binding]; other site 272630000091 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 272630000092 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 272630000093 putative GSH binding site [chemical binding]; other site 272630000094 catalytic residues [active] 272630000095 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272630000096 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272630000097 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 272630000098 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272630000099 PAS fold; Region: PAS_3; pfam08447 272630000100 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 272630000101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630000102 dimer interface [polypeptide binding]; other site 272630000103 phosphorylation site [posttranslational modification] 272630000104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630000105 ATP binding site [chemical binding]; other site 272630000106 Mg2+ binding site [ion binding]; other site 272630000107 G-X-G motif; other site 272630000108 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630000109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630000110 active site 272630000111 phosphorylation site [posttranslational modification] 272630000112 intermolecular recognition site; other site 272630000113 dimerization interface [polypeptide binding]; other site 272630000114 circadian clock protein KaiC; Reviewed; Region: PRK09302 272630000115 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272630000116 Walker A motif; other site 272630000117 ATP binding site [chemical binding]; other site 272630000118 Walker B motif; other site 272630000119 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272630000120 ATP binding site [chemical binding]; other site 272630000121 Walker A motif; other site 272630000122 Walker B motif; other site 272630000123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 272630000124 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 272630000125 short chain dehydrogenase; Provisional; Region: PRK06181 272630000126 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 272630000127 putative NAD(P) binding site [chemical binding]; other site 272630000128 active site 272630000129 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272630000130 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272630000131 DNA-binding site [nucleotide binding]; DNA binding site 272630000132 FCD domain; Region: FCD; pfam07729 272630000133 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 272630000134 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 272630000135 Coenzyme A transferase; Region: CoA_trans; cl17247 272630000136 malonate decarboxylase subunit delta; Provisional; Region: PRK02103 272630000137 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 272630000138 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 272630000139 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 272630000140 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK02098 272630000141 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 272630000142 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272630000143 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 272630000144 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 272630000145 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 272630000146 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 272630000147 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 272630000148 general secretion pathway protein J; Validated; Region: PRK08808 272630000149 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 272630000150 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 272630000151 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 272630000152 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272630000153 Cu(I) binding site [ion binding]; other site 272630000154 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 272630000155 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 272630000156 putative sugar binding sites [chemical binding]; other site 272630000157 Q-X-W motif; other site 272630000158 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 272630000159 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 272630000160 putative sugar binding sites [chemical binding]; other site 272630000161 Q-X-W motif; other site 272630000162 Kelch motif; Region: Kelch_6; pfam13964 272630000163 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 272630000164 Kelch motif; Region: Kelch_6; pfam13964 272630000165 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 272630000166 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 272630000167 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 272630000168 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 272630000169 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 272630000170 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272630000171 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272630000172 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 272630000173 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 272630000174 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 272630000175 Walker A motif; other site 272630000176 ATP binding site [chemical binding]; other site 272630000177 Walker B motif; other site 272630000178 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 272630000179 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 272630000180 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 272630000181 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 272630000182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630000183 catalytic residue [active] 272630000184 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 272630000185 active site 272630000186 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 272630000187 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272630000188 IHF dimer interface [polypeptide binding]; other site 272630000189 IHF - DNA interface [nucleotide binding]; other site 272630000190 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 272630000191 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 272630000192 tandem repeat interface [polypeptide binding]; other site 272630000193 oligomer interface [polypeptide binding]; other site 272630000194 active site residues [active] 272630000195 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 272630000196 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 272630000197 RNA binding site [nucleotide binding]; other site 272630000198 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 272630000199 RNA binding site [nucleotide binding]; other site 272630000200 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 272630000201 RNA binding site [nucleotide binding]; other site 272630000202 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272630000203 RNA binding site [nucleotide binding]; other site 272630000204 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 272630000205 RNA binding site [nucleotide binding]; other site 272630000206 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 272630000207 RNA binding site [nucleotide binding]; other site 272630000208 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272630000209 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 272630000210 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272630000211 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272630000212 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272630000213 active site 272630000214 Int/Topo IB signature motif; other site 272630000215 DNA binding site [nucleotide binding] 272630000216 Uncharacterized conserved protein [Function unknown]; Region: COG4544 272630000217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630000218 ATP binding site [chemical binding]; other site 272630000219 Mg2+ binding site [ion binding]; other site 272630000220 G-X-G motif; other site 272630000221 Z1 domain; Region: Z1; pfam10593 272630000222 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 272630000223 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 272630000224 additional DNA contacts [nucleotide binding]; other site 272630000225 mismatch recognition site; other site 272630000226 active site 272630000227 zinc binding site [ion binding]; other site 272630000228 DNA intercalation site [nucleotide binding]; other site 272630000229 Protein of unknown function (DUF3768); Region: DUF3768; pfam12599 272630000230 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272630000231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630000232 non-specific DNA binding site [nucleotide binding]; other site 272630000233 salt bridge; other site 272630000234 sequence-specific DNA binding site [nucleotide binding]; other site 272630000235 Short C-terminal domain; Region: SHOCT; pfam09851 272630000236 Domain of unknown function (DUF927); Region: DUF927; cl12098 272630000237 Class I aldolases; Region: Aldolase_Class_I; cl17187 272630000238 Pirin-related protein [General function prediction only]; Region: COG1741 272630000239 Pirin; Region: Pirin; pfam02678 272630000240 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 272630000241 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272630000242 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 272630000243 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 272630000244 TrkA-N domain; Region: TrkA_N; pfam02254 272630000245 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 272630000246 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 272630000247 minor groove reading motif; other site 272630000248 helix-hairpin-helix signature motif; other site 272630000249 substrate binding pocket [chemical binding]; other site 272630000250 active site 272630000251 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 272630000252 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630000253 dimer interface [polypeptide binding]; other site 272630000254 putative CheW interface [polypeptide binding]; other site 272630000255 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272630000256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630000257 Walker A/P-loop; other site 272630000258 ATP binding site [chemical binding]; other site 272630000259 Q-loop/lid; other site 272630000260 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272630000261 ABC transporter signature motif; other site 272630000262 Walker B; other site 272630000263 D-loop; other site 272630000264 ABC transporter; Region: ABC_tran_2; pfam12848 272630000265 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272630000266 Protein of unknown function (DUF419); Region: DUF419; pfam04237 272630000267 Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777 272630000268 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272630000269 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272630000270 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630000271 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630000272 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 272630000273 putative ADP-binding pocket [chemical binding]; other site 272630000274 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 272630000275 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 272630000276 putative ADP-binding pocket [chemical binding]; other site 272630000277 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 272630000278 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272630000279 active site 272630000280 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 272630000281 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 272630000282 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272630000283 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272630000284 active site 272630000285 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630000286 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 272630000287 putative ADP-binding pocket [chemical binding]; other site 272630000288 Methyltransferase domain; Region: Methyltransf_24; pfam13578 272630000289 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 272630000290 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 272630000291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630000292 active site 272630000293 phosphorylation site [posttranslational modification] 272630000294 intermolecular recognition site; other site 272630000295 dimerization interface [polypeptide binding]; other site 272630000296 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272630000297 Zn2+ binding site [ion binding]; other site 272630000298 Mg2+ binding site [ion binding]; other site 272630000299 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 272630000300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630000301 Walker A/P-loop; other site 272630000302 ATP binding site [chemical binding]; other site 272630000303 Q-loop/lid; other site 272630000304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630000305 ABC transporter signature motif; other site 272630000306 Walker B; other site 272630000307 D-loop; other site 272630000308 H-loop/switch region; other site 272630000309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630000310 Walker A/P-loop; other site 272630000311 ATP binding site [chemical binding]; other site 272630000312 Q-loop/lid; other site 272630000313 ABC transporter signature motif; other site 272630000314 Walker B; other site 272630000315 D-loop; other site 272630000316 H-loop/switch region; other site 272630000317 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 272630000318 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 272630000319 conserved cys residue [active] 272630000320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272630000321 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272630000322 classical (c) SDRs; Region: SDR_c; cd05233 272630000323 NAD(P) binding site [chemical binding]; other site 272630000324 active site 272630000325 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 272630000326 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272630000327 catalytic loop [active] 272630000328 iron binding site [ion binding]; other site 272630000329 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 272630000330 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 272630000331 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272630000332 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 272630000333 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272630000334 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272630000335 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 272630000336 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 272630000337 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 272630000338 ligand binding site [chemical binding]; other site 272630000339 NAD binding site [chemical binding]; other site 272630000340 tetramer interface [polypeptide binding]; other site 272630000341 catalytic site [active] 272630000342 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 272630000343 L-serine binding site [chemical binding]; other site 272630000344 ACT domain interface; other site 272630000345 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272630000346 FAD binding domain; Region: FAD_binding_4; pfam01565 272630000347 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 272630000348 heme-binding residues [chemical binding]; other site 272630000349 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272630000350 molybdopterin cofactor binding site; other site 272630000351 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 272630000352 4Fe-4S binding domain; Region: Fer4_2; pfam12797 272630000353 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 272630000354 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 272630000355 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 272630000356 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 272630000357 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272630000358 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 272630000359 Cytochrome c; Region: Cytochrom_C; pfam00034 272630000360 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 272630000361 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 272630000362 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 272630000363 Subunit I/III interface [polypeptide binding]; other site 272630000364 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 272630000365 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 272630000366 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630000367 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272630000368 DNA binding residues [nucleotide binding] 272630000369 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 272630000370 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 272630000371 putative heme binding pocket [chemical binding]; other site 272630000372 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 272630000373 potassium-transporting ATPase subunit F; Provisional; Region: PRK14759 272630000374 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 272630000375 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 272630000376 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272630000377 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272630000378 potassium-transporting ATPase subunit C; Provisional; Region: PRK13999 272630000379 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 272630000380 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 272630000381 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 272630000382 Ligand Binding Site [chemical binding]; other site 272630000383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630000384 dimer interface [polypeptide binding]; other site 272630000385 phosphorylation site [posttranslational modification] 272630000386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630000387 ATP binding site [chemical binding]; other site 272630000388 Mg2+ binding site [ion binding]; other site 272630000389 G-X-G motif; other site 272630000390 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272630000391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630000392 active site 272630000393 phosphorylation site [posttranslational modification] 272630000394 intermolecular recognition site; other site 272630000395 dimerization interface [polypeptide binding]; other site 272630000396 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630000397 DNA binding site [nucleotide binding] 272630000398 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 272630000399 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 272630000400 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 272630000401 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272630000402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630000403 S-adenosylmethionine binding site [chemical binding]; other site 272630000404 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 272630000405 catalytic core [active] 272630000406 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 272630000407 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 272630000408 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 272630000409 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272630000410 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 272630000411 NAD binding site [chemical binding]; other site 272630000412 putative substrate binding site 2 [chemical binding]; other site 272630000413 putative substrate binding site 1 [chemical binding]; other site 272630000414 active site 272630000415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 272630000416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630000417 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 272630000418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 272630000419 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 272630000420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 272630000421 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272630000422 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 272630000423 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272630000424 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 272630000425 B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295 272630000426 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 272630000427 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630000428 FeS/SAM binding site; other site 272630000429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630000430 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272630000431 NAD(P) binding site [chemical binding]; other site 272630000432 active site 272630000433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630000434 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272630000435 NAD(P) binding site [chemical binding]; other site 272630000436 active site 272630000437 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 272630000438 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272630000439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272630000440 PilZ domain; Region: PilZ; pfam07238 272630000441 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272630000442 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272630000443 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272630000444 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272630000445 potential protein location (conserved hypothetical protein, flagellin protein (fragment)) that overlaps protein (conserved hypothetical protein, flagellin protein (fragment)) 272630000446 potential protein location (conserved hypothetical protein, flagellin protein (fragment)) that overlaps protein (conserved hypothetical protein, flagellin protein (fragment)) 272630000447 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272630000448 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272630000449 active site 272630000450 DNA binding site [nucleotide binding] 272630000451 Int/Topo IB signature motif; other site 272630000452 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272630000453 multiple promoter invertase; Provisional; Region: mpi; PRK13413 272630000454 catalytic residues [active] 272630000455 catalytic nucleophile [active] 272630000456 Presynaptic Site I dimer interface [polypeptide binding]; other site 272630000457 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272630000458 Synaptic Flat tetramer interface [polypeptide binding]; other site 272630000459 Synaptic Site I dimer interface [polypeptide binding]; other site 272630000460 DNA binding site [nucleotide binding] 272630000461 Homeodomain-like domain; Region: HTH_23; cl17451 272630000462 recombination factor protein RarA; Reviewed; Region: PRK13342 272630000463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630000464 Walker A motif; other site 272630000465 ATP binding site [chemical binding]; other site 272630000466 Walker B motif; other site 272630000467 arginine finger; other site 272630000468 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 272630000469 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 272630000470 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 272630000471 active site 272630000472 Zn binding site [ion binding]; other site 272630000473 putative chaperone; Provisional; Region: PRK11678 272630000474 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 272630000475 nucleotide binding site [chemical binding]; other site 272630000476 putative NEF/HSP70 interaction site [polypeptide binding]; other site 272630000477 SBD interface [polypeptide binding]; other site 272630000478 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272630000479 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 272630000480 RNA binding surface [nucleotide binding]; other site 272630000481 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272630000482 active site 272630000483 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272630000484 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272630000485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272630000486 motif II; other site 272630000487 ATP12 chaperone protein; Region: ATP12; cl02228 272630000488 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 272630000489 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 272630000490 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 272630000491 tellurium resistance terB-like protein; Region: terB_like; cd07177 272630000492 metal binding site [ion binding]; metal-binding site 272630000493 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272630000494 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272630000495 ketol-acid reductoisomerase; Provisional; Region: PRK05479 272630000496 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 272630000497 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 272630000498 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 272630000499 Methyltransferase domain; Region: Methyltransf_24; pfam13578 272630000500 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 272630000501 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 272630000502 putative NAD(P) binding site [chemical binding]; other site 272630000503 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 272630000504 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 272630000505 tetramer interface [polypeptide binding]; other site 272630000506 heme binding pocket [chemical binding]; other site 272630000507 NADPH binding site [chemical binding]; other site 272630000508 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, MeaA-like subfamily; contains various methylmalonyl coenzyme A (CoA) mutase (MCM)-like proteins similar to the Streptomyces cinnamonensis MeaA, Methylobacterium extorquens MeaA...; Region: MM_CoA_mutase_MeaA; cd03681 272630000509 putative active site [active] 272630000510 putative substrate binding site [chemical binding]; other site 272630000511 putative coenzyme B12 binding site [chemical binding]; other site 272630000512 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 272630000513 B12 binding site [chemical binding]; other site 272630000514 cobalt ligand [ion binding]; other site 272630000515 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 272630000516 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272630000517 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 272630000518 NADP binding site [chemical binding]; other site 272630000519 homodimer interface [polypeptide binding]; other site 272630000520 active site 272630000521 substrate binding site [chemical binding]; other site 272630000522 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272630000523 dimerization interface [polypeptide binding]; other site 272630000524 putative DNA binding site [nucleotide binding]; other site 272630000525 putative Zn2+ binding site [ion binding]; other site 272630000526 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 272630000527 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272630000528 active site 272630000529 HIGH motif; other site 272630000530 dimer interface [polypeptide binding]; other site 272630000531 KMSKS motif; other site 272630000532 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 272630000533 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 272630000534 substrate binding site [chemical binding]; other site 272630000535 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 272630000536 putative substrate binding pocket [chemical binding]; other site 272630000537 AC domain interface; other site 272630000538 catalytic triad [active] 272630000539 AB domain interface; other site 272630000540 membrane ATPase/protein kinase; Provisional; Region: PRK09435 272630000541 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 272630000542 Walker A; other site 272630000543 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 272630000544 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 272630000545 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272630000546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272630000547 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630000548 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 272630000549 active site 272630000550 metal binding site [ion binding]; metal-binding site 272630000551 DNA binding site [nucleotide binding] 272630000552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630000553 Walker A/P-loop; other site 272630000554 ATP binding site [chemical binding]; other site 272630000555 Q-loop/lid; other site 272630000556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630000557 ABC transporter signature motif; other site 272630000558 Walker B; other site 272630000559 D-loop; other site 272630000560 H-loop/switch region; other site 272630000561 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 272630000562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630000563 putative substrate translocation pore; other site 272630000564 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 272630000565 Methyltransferase domain; Region: Methyltransf_11; pfam08241 272630000566 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 272630000567 Domain of unknown function (DUF427); Region: DUF427; pfam04248 272630000568 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 272630000569 active site 272630000570 8-oxo-dGMP binding site [chemical binding]; other site 272630000571 nudix motif; other site 272630000572 metal binding site [ion binding]; metal-binding site 272630000573 Uncharacterized conserved protein [Function unknown]; Region: COG2968 272630000574 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 272630000575 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 272630000576 heterotetramer interface [polypeptide binding]; other site 272630000577 active site pocket [active] 272630000578 cleavage site 272630000579 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 272630000580 catalytic residues [active] 272630000581 dimer interface [polypeptide binding]; other site 272630000582 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 272630000583 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 272630000584 Proline dehydrogenase; Region: Pro_dh; cl03282 272630000585 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 272630000586 Glutamate binding site [chemical binding]; other site 272630000587 NAD binding site [chemical binding]; other site 272630000588 catalytic residues [active] 272630000589 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272630000590 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 272630000591 Part of AAA domain; Region: AAA_19; pfam13245 272630000592 Family description; Region: UvrD_C_2; pfam13538 272630000593 PhoH-like protein; Region: PhoH; pfam02562 272630000594 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272630000595 amphipathic channel; other site 272630000596 Asn-Pro-Ala signature motifs; other site 272630000597 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 272630000598 active site 272630000599 catalytic site [active] 272630000600 substrate binding site [chemical binding]; other site 272630000601 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 272630000602 Cupin; Region: Cupin_1; smart00835 272630000603 Cupin; Region: Cupin_1; smart00835 272630000604 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 272630000605 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272630000606 metal binding triad; other site 272630000607 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 272630000608 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272630000609 metal binding triad; other site 272630000610 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 272630000611 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 272630000612 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 272630000613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630000614 dimerization interface [polypeptide binding]; other site 272630000615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630000616 dimer interface [polypeptide binding]; other site 272630000617 phosphorylation site [posttranslational modification] 272630000618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630000619 ATP binding site [chemical binding]; other site 272630000620 Mg2+ binding site [ion binding]; other site 272630000621 G-X-G motif; other site 272630000622 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272630000623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630000624 active site 272630000625 phosphorylation site [posttranslational modification] 272630000626 intermolecular recognition site; other site 272630000627 dimerization interface [polypeptide binding]; other site 272630000628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630000629 DNA binding site [nucleotide binding] 272630000630 OsmC-like protein; Region: OsmC; pfam02566 272630000631 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272630000632 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272630000633 Walker A/P-loop; other site 272630000634 ATP binding site [chemical binding]; other site 272630000635 Q-loop/lid; other site 272630000636 ABC transporter signature motif; other site 272630000637 Walker B; other site 272630000638 D-loop; other site 272630000639 H-loop/switch region; other site 272630000640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272630000641 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272630000642 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 272630000643 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272630000644 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272630000645 substrate binding pocket [chemical binding]; other site 272630000646 membrane-bound complex binding site; other site 272630000647 PII uridylyl-transferase; Provisional; Region: PRK05092 272630000648 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272630000649 metal binding triad; other site 272630000650 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 272630000651 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272630000652 Zn2+ binding site [ion binding]; other site 272630000653 Mg2+ binding site [ion binding]; other site 272630000654 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 272630000655 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 272630000656 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272630000657 dimer interface [polypeptide binding]; other site 272630000658 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272630000659 Protein of unknown function (DUF497); Region: DUF497; cl01108 272630000660 prephenate dehydratase; Provisional; Region: PRK11899 272630000661 Prephenate dehydratase; Region: PDT; pfam00800 272630000662 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 272630000663 putative L-Phe binding site [chemical binding]; other site 272630000664 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272630000665 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 272630000666 active site 272630000667 Cytochrome c2 [Energy production and conversion]; Region: COG3474 272630000668 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272630000669 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 272630000670 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272630000671 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 272630000672 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 272630000673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630000674 dimer interface [polypeptide binding]; other site 272630000675 conserved gate region; other site 272630000676 putative PBP binding loops; other site 272630000677 ABC-ATPase subunit interface; other site 272630000678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272630000679 Coenzyme A binding pocket [chemical binding]; other site 272630000680 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 272630000681 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272630000682 acyl-activating enzyme (AAE) consensus motif; other site 272630000683 AMP binding site [chemical binding]; other site 272630000684 active site 272630000685 CoA binding site [chemical binding]; other site 272630000686 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 272630000687 putative metal binding site; other site 272630000688 Cytochrome c; Region: Cytochrom_C; cl11414 272630000689 potassium-tellurite ethidium and proflavin transporter; Provisional; Region: PRK10764 272630000690 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 272630000691 gating phenylalanine in ion channel; other site 272630000692 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272630000693 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272630000694 DNA-binding site [nucleotide binding]; DNA binding site 272630000695 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272630000696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630000697 homodimer interface [polypeptide binding]; other site 272630000698 catalytic residue [active] 272630000699 Protein of unknown function (DUF983); Region: DUF983; cl02211 272630000700 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272630000701 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272630000702 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272630000703 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272630000704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272630000705 DNA-binding site [nucleotide binding]; DNA binding site 272630000706 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272630000707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630000708 homodimer interface [polypeptide binding]; other site 272630000709 catalytic residue [active] 272630000710 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 272630000711 Predicted amidohydrolase [General function prediction only]; Region: COG0388 272630000712 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 272630000713 putative active site [active] 272630000714 catalytic triad [active] 272630000715 putative dimer interface [polypeptide binding]; other site 272630000716 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 272630000717 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630000718 FeS/SAM binding site; other site 272630000719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272630000720 Coenzyme A binding pocket [chemical binding]; other site 272630000721 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 272630000722 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 272630000723 dimerization interface [polypeptide binding]; other site 272630000724 putative ATP binding site [chemical binding]; other site 272630000725 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 272630000726 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272630000727 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 272630000728 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 272630000729 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272630000730 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 272630000731 biosynthesis cluster domain; Region: biosyn_clust_1; cl14822 272630000732 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 272630000733 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 272630000734 conserved cys residue [active] 272630000735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272630000736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272630000737 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 272630000738 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 272630000739 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 272630000740 PAS domain; Region: PAS_9; pfam13426 272630000741 PAS domain S-box; Region: sensory_box; TIGR00229 272630000742 PAS domain S-box; Region: sensory_box; TIGR00229 272630000743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630000744 putative active site [active] 272630000745 heme pocket [chemical binding]; other site 272630000746 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272630000747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630000748 DNA binding residues [nucleotide binding] 272630000749 dimerization interface [polypeptide binding]; other site 272630000750 CsbD-like; Region: CsbD; cl17424 272630000751 CsbD-like; Region: CsbD; pfam05532 272630000752 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 272630000753 CsbD-like; Region: CsbD; pfam05532 272630000754 CsbD-like; Region: CsbD; pfam05532 272630000755 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 272630000756 acetylornithine deacetylase; Provisional; Region: PRK07522 272630000757 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 272630000758 metal binding site [ion binding]; metal-binding site 272630000759 putative dimer interface [polypeptide binding]; other site 272630000760 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 272630000761 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 272630000762 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 272630000763 trimer interface [polypeptide binding]; other site 272630000764 active site 272630000765 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 272630000766 trimer interface [polypeptide binding]; other site 272630000767 active site 272630000768 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 272630000769 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 272630000770 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 272630000771 putative MPT binding site; other site 272630000772 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 272630000773 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 272630000774 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272630000775 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272630000776 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 272630000777 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272630000778 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272630000779 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272630000780 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 272630000781 Walker A/P-loop; other site 272630000782 ATP binding site [chemical binding]; other site 272630000783 Q-loop/lid; other site 272630000784 ABC transporter signature motif; other site 272630000785 Walker B; other site 272630000786 D-loop; other site 272630000787 H-loop/switch region; other site 272630000788 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 272630000789 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 272630000790 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 272630000791 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 272630000792 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 272630000793 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 272630000794 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 272630000795 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 272630000796 [4Fe-4S] binding site [ion binding]; other site 272630000797 molybdopterin cofactor binding site; other site 272630000798 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272630000799 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 272630000800 molybdopterin cofactor binding site; other site 272630000801 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 272630000802 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 272630000803 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 272630000804 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 272630000805 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 272630000806 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272630000807 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 272630000808 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272630000809 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272630000810 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630000811 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272630000812 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 272630000813 ribonuclease PH; Reviewed; Region: rph; PRK00173 272630000814 Ribonuclease PH; Region: RNase_PH_bact; cd11362 272630000815 hexamer interface [polypeptide binding]; other site 272630000816 active site 272630000817 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 272630000818 active site 272630000819 dimerization interface [polypeptide binding]; other site 272630000820 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 272630000821 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630000822 FeS/SAM binding site; other site 272630000823 HemN C-terminal domain; Region: HemN_C; pfam06969 272630000824 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 272630000825 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 272630000826 putative ligand binding site [chemical binding]; other site 272630000827 Predicted methyltransferases [General function prediction only]; Region: COG0313 272630000828 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 272630000829 putative SAM binding site [chemical binding]; other site 272630000830 putative homodimer interface [polypeptide binding]; other site 272630000831 hypothetical protein; Provisional; Region: PRK14679 272630000832 Response regulator receiver domain; Region: Response_reg; pfam00072 272630000833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630000834 active site 272630000835 phosphorylation site [posttranslational modification] 272630000836 intermolecular recognition site; other site 272630000837 dimerization interface [polypeptide binding]; other site 272630000838 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 272630000839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272630000840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630000841 putative PBP binding loops; other site 272630000842 ABC-ATPase subunit interface; other site 272630000843 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272630000844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272630000845 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630000846 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 272630000847 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 272630000848 active site 272630000849 Zn binding site [ion binding]; other site 272630000850 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 272630000851 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 272630000852 Potassium binding sites [ion binding]; other site 272630000853 Cesium cation binding sites [ion binding]; other site 272630000854 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272630000855 metal-binding site [ion binding] 272630000856 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630000857 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 272630000858 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 272630000859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630000860 active site 272630000861 phosphorylation site [posttranslational modification] 272630000862 intermolecular recognition site; other site 272630000863 dimerization interface [polypeptide binding]; other site 272630000864 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 272630000865 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 272630000866 active site 272630000867 Riboflavin kinase; Region: Flavokinase; pfam01687 272630000868 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272630000869 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 272630000870 dimerization interface [polypeptide binding]; other site 272630000871 ligand binding site [chemical binding]; other site 272630000872 NADP binding site [chemical binding]; other site 272630000873 catalytic site [active] 272630000874 Bacterial SH3 domain; Region: SH3_4; pfam06347 272630000875 Bacterial SH3 domain; Region: SH3_4; pfam06347 272630000876 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272630000877 metal binding site 2 [ion binding]; metal-binding site 272630000878 putative DNA binding helix; other site 272630000879 metal binding site 1 [ion binding]; metal-binding site 272630000880 dimer interface [polypeptide binding]; other site 272630000881 structural Zn2+ binding site [ion binding]; other site 272630000882 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 272630000883 active site 1 [active] 272630000884 dimer interface [polypeptide binding]; other site 272630000885 active site 2 [active] 272630000886 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 272630000887 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272630000888 dimer interface [polypeptide binding]; other site 272630000889 active site 272630000890 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 272630000891 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 272630000892 NAD binding site [chemical binding]; other site 272630000893 homotetramer interface [polypeptide binding]; other site 272630000894 homodimer interface [polypeptide binding]; other site 272630000895 substrate binding site [chemical binding]; other site 272630000896 active site 272630000897 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 272630000898 Predicted membrane protein [Function unknown]; Region: COG2259 272630000899 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 272630000900 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272630000901 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 272630000902 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 272630000903 PAS domain S-box; Region: sensory_box; TIGR00229 272630000904 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630000905 putative active site [active] 272630000906 heme pocket [chemical binding]; other site 272630000907 Histidine kinase; Region: HisKA_2; pfam07568 272630000908 PAS domain; Region: PAS; smart00091 272630000909 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 272630000910 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272630000911 dimer interface [polypeptide binding]; other site 272630000912 active site 272630000913 glutathione binding site [chemical binding]; other site 272630000914 aminopeptidase N; Provisional; Region: pepN; PRK14015 272630000915 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 272630000916 Zn binding site [ion binding]; other site 272630000917 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 272630000918 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630000919 PAS fold; Region: PAS_3; pfam08447 272630000920 putative active site [active] 272630000921 heme pocket [chemical binding]; other site 272630000922 PAS fold; Region: PAS_7; pfam12860 272630000923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630000924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630000925 dimer interface [polypeptide binding]; other site 272630000926 phosphorylation site [posttranslational modification] 272630000927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630000928 ATP binding site [chemical binding]; other site 272630000929 Mg2+ binding site [ion binding]; other site 272630000930 G-X-G motif; other site 272630000931 Arginase family; Region: Arginase; cd09989 272630000932 active site 272630000933 Mn binding site [ion binding]; other site 272630000934 oligomer interface [polypeptide binding]; other site 272630000935 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 272630000936 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 272630000937 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 272630000938 PilZ domain; Region: PilZ; pfam07238 272630000939 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 272630000940 ATP-NAD kinase; Region: NAD_kinase; pfam01513 272630000941 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 272630000942 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 272630000943 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 272630000944 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 272630000945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630000946 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 272630000947 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 272630000948 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 272630000949 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272630000950 catalytic residue [active] 272630000951 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272630000952 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272630000953 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 272630000954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630000955 NAD(P) binding site [chemical binding]; other site 272630000956 active site 272630000957 acyl carrier protein; Provisional; Region: acpP; PRK00982 272630000958 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 272630000959 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272630000960 dimer interface [polypeptide binding]; other site 272630000961 active site 272630000962 YceG-like family; Region: YceG; pfam02618 272630000963 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 272630000964 dimerization interface [polypeptide binding]; other site 272630000965 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 272630000966 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272630000967 motif II; other site 272630000968 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 272630000969 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 272630000970 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 272630000971 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 272630000972 Acetokinase family; Region: Acetate_kinase; cl17229 272630000973 propionate/acetate kinase; Provisional; Region: PRK12379 272630000974 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272630000975 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272630000976 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630000977 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272630000978 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272630000979 Walker A/P-loop; other site 272630000980 ATP binding site [chemical binding]; other site 272630000981 Q-loop/lid; other site 272630000982 ABC transporter signature motif; other site 272630000983 Walker B; other site 272630000984 D-loop; other site 272630000985 H-loop/switch region; other site 272630000986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630000987 Walker A/P-loop; other site 272630000988 ATP binding site [chemical binding]; other site 272630000989 Q-loop/lid; other site 272630000990 ABC transporter signature motif; other site 272630000991 Walker B; other site 272630000992 D-loop; other site 272630000993 H-loop/switch region; other site 272630000994 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272630000995 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272630000996 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272630000997 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272630000998 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272630000999 putative phosphoketolase; Provisional; Region: PRK05261 272630001000 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 272630001001 TPP-binding site; other site 272630001002 XFP C-terminal domain; Region: XFP_C; pfam09363 272630001003 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 272630001004 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272630001005 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272630001006 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630001007 Walker A/P-loop; other site 272630001008 ATP binding site [chemical binding]; other site 272630001009 Q-loop/lid; other site 272630001010 ABC transporter signature motif; other site 272630001011 Walker B; other site 272630001012 D-loop; other site 272630001013 H-loop/switch region; other site 272630001014 TOBE domain; Region: TOBE_2; pfam08402 272630001015 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 272630001016 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 272630001017 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 272630001018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630001019 ABC-ATPase subunit interface; other site 272630001020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630001021 putative PBP binding loops; other site 272630001022 dimer interface [polypeptide binding]; other site 272630001023 ABC-ATPase subunit interface; other site 272630001024 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272630001025 Kelch motif; Region: Kelch_1; pfam01344 272630001026 Kelch motif; Region: Kelch_6; pfam13964 272630001027 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 272630001028 Galactose oxidase, central domain; Region: Kelch_3; cl02701 272630001029 Kelch domain; Region: Kelch; smart00612 272630001030 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 272630001031 Kelch domain; Region: Kelch; smart00612 272630001032 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 272630001033 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272630001034 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 272630001035 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272630001036 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272630001037 ligand binding site [chemical binding]; other site 272630001038 flexible hinge region; other site 272630001039 Cupin domain; Region: Cupin_2; cl17218 272630001040 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 272630001041 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 272630001042 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272630001043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630001044 dimer interface [polypeptide binding]; other site 272630001045 conserved gate region; other site 272630001046 putative PBP binding loops; other site 272630001047 ABC-ATPase subunit interface; other site 272630001048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630001049 dimer interface [polypeptide binding]; other site 272630001050 conserved gate region; other site 272630001051 putative PBP binding loops; other site 272630001052 ABC-ATPase subunit interface; other site 272630001053 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 272630001054 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 272630001055 Walker A/P-loop; other site 272630001056 ATP binding site [chemical binding]; other site 272630001057 Q-loop/lid; other site 272630001058 ABC transporter signature motif; other site 272630001059 Walker B; other site 272630001060 D-loop; other site 272630001061 H-loop/switch region; other site 272630001062 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 272630001063 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 272630001064 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272630001065 minor groove reading motif; other site 272630001066 helix-hairpin-helix signature motif; other site 272630001067 substrate binding pocket [chemical binding]; other site 272630001068 active site 272630001069 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 272630001070 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 272630001071 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 272630001072 ATP binding site [chemical binding]; other site 272630001073 active site 272630001074 substrate binding site [chemical binding]; other site 272630001075 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272630001076 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272630001077 Probable Catalytic site; other site 272630001078 metal-binding site 272630001079 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272630001080 active site 272630001081 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272630001082 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272630001083 Probable Catalytic site; other site 272630001084 metal-binding site 272630001085 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 272630001086 Protein of unknown function DUF45; Region: DUF45; pfam01863 272630001087 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 272630001088 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 272630001089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630001090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630001091 dimer interface [polypeptide binding]; other site 272630001092 phosphorylation site [posttranslational modification] 272630001093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630001094 ATP binding site [chemical binding]; other site 272630001095 Mg2+ binding site [ion binding]; other site 272630001096 G-X-G motif; other site 272630001097 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 272630001098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630001099 active site 272630001100 phosphorylation site [posttranslational modification] 272630001101 intermolecular recognition site; other site 272630001102 dimerization interface [polypeptide binding]; other site 272630001103 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272630001104 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 272630001105 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 272630001106 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 272630001107 putative active site [active] 272630001108 catalytic triad [active] 272630001109 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272630001110 active site 272630001111 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272630001112 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 272630001113 active site 272630001114 dimerization interface [polypeptide binding]; other site 272630001115 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272630001116 active site 272630001117 pyrophosphate binding site [ion binding]; other site 272630001118 thiamine phosphate binding site [chemical binding]; other site 272630001119 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 272630001120 ThiS interaction site; other site 272630001121 putative active site [active] 272630001122 tetramer interface [polypeptide binding]; other site 272630001123 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 272630001124 thiS-thiF/thiG interaction site; other site 272630001125 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272630001126 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 272630001127 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272630001128 cyclase homology domain; Region: CHD; cd07302 272630001129 nucleotidyl binding site; other site 272630001130 metal binding site [ion binding]; metal-binding site 272630001131 dimer interface [polypeptide binding]; other site 272630001132 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 272630001133 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 272630001134 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272630001135 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 272630001136 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 272630001137 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630001138 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272630001139 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272630001140 DNA binding residues [nucleotide binding] 272630001141 DNA primase, catalytic core; Region: dnaG; TIGR01391 272630001142 CHC2 zinc finger; Region: zf-CHC2; pfam01807 272630001143 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272630001144 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272630001145 active site 272630001146 metal binding site [ion binding]; metal-binding site 272630001147 interdomain interaction site; other site 272630001148 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 272630001149 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 272630001150 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 272630001151 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 272630001152 Yqey-like protein; Region: YqeY; pfam09424 272630001153 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 272630001154 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 272630001155 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 272630001156 catalytic site [active] 272630001157 subunit interface [polypeptide binding]; other site 272630001158 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 272630001159 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272630001160 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 272630001161 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272630001162 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 272630001163 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12692 272630001164 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272630001165 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272630001166 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 272630001167 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 272630001168 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 272630001169 flagellar basal body P-ring protein; Reviewed; Region: flgI; PRK12789 272630001170 Flagellar P-ring protein; Region: FlgI; pfam02119 272630001171 Uncharacterized conserved protein [Function unknown]; Region: COG3334 272630001172 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 272630001173 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788 272630001174 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 272630001175 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK12783 272630001176 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 272630001177 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 272630001178 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 272630001179 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 272630001180 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272630001181 ligand binding site [chemical binding]; other site 272630001182 chemotaxis protein; Reviewed; Region: PRK12798 272630001183 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272630001184 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272630001185 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272630001186 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 272630001187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630001188 active site 272630001189 dimerization interface [polypeptide binding]; other site 272630001190 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630001191 DNA binding site [nucleotide binding] 272630001192 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK13109 272630001193 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 272630001194 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 272630001195 FliG C-terminal domain; Region: FliG_C; pfam01706 272630001196 flagellar motor switch protein FliN; Region: fliN; TIGR02480 272630001197 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 272630001198 Flagellar motor switch protein FliM; Region: FliM; pfam02154 272630001199 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 272630001200 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 272630001201 flagellar motor protein MotA; Validated; Region: PRK09110 272630001202 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 272630001203 active site 272630001204 HslU subunit interaction site [polypeptide binding]; other site 272630001205 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 272630001206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630001207 Walker A motif; other site 272630001208 ATP binding site [chemical binding]; other site 272630001209 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 272630001210 Walker B motif; other site 272630001211 arginine finger; other site 272630001212 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272630001213 threonine and homoserine efflux system; Provisional; Region: PRK10532 272630001214 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 272630001215 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 272630001216 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 272630001217 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 272630001218 [2Fe-2S] cluster binding site [ion binding]; other site 272630001219 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 272630001220 hydrophobic ligand binding site; other site 272630001221 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 272630001222 signal recognition particle protein; Provisional; Region: PRK10867 272630001223 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272630001224 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272630001225 P loop; other site 272630001226 GTP binding site [chemical binding]; other site 272630001227 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272630001228 chorismate mutase; Provisional; Region: PRK09239 272630001229 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 272630001230 RimM N-terminal domain; Region: RimM; pfam01782 272630001231 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 272630001232 PRC-barrel domain; Region: PRC; pfam05239 272630001233 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 272630001234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630001235 S-adenosylmethionine binding site [chemical binding]; other site 272630001236 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 272630001237 serC leader; MexAM1_META1pmiscRNA1 272630001238 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 272630001239 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272630001240 catalytic residue [active] 272630001241 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 272630001242 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 272630001243 ligand binding site [chemical binding]; other site 272630001244 NAD binding site [chemical binding]; other site 272630001245 dimerization interface [polypeptide binding]; other site 272630001246 catalytic site [active] 272630001247 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 272630001248 putative L-serine binding site [chemical binding]; other site 272630001249 Domain of unknown function (DUF1902); Region: DUF1902; pfam08972 272630001250 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 272630001251 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 272630001252 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 272630001253 multidrug efflux protein; Reviewed; Region: PRK01766 272630001254 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 272630001255 cation binding site [ion binding]; other site 272630001256 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272630001257 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 272630001258 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272630001259 Walker A/P-loop; other site 272630001260 ATP binding site [chemical binding]; other site 272630001261 Q-loop/lid; other site 272630001262 ABC transporter signature motif; other site 272630001263 Walker B; other site 272630001264 D-loop; other site 272630001265 H-loop/switch region; other site 272630001266 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 272630001267 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630001268 dimer interface [polypeptide binding]; other site 272630001269 putative CheW interface [polypeptide binding]; other site 272630001270 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 272630001271 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 272630001272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 272630001273 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 272630001274 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 272630001275 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272630001276 N-terminal plug; other site 272630001277 ligand-binding site [chemical binding]; other site 272630001278 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 272630001279 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 272630001280 AAA domain; Region: AAA_30; pfam13604 272630001281 Family description; Region: UvrD_C_2; pfam13538 272630001282 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 272630001283 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272630001284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630001285 homodimer interface [polypeptide binding]; other site 272630001286 catalytic residue [active] 272630001287 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272630001288 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630001289 DNA binding site [nucleotide binding] 272630001290 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272630001291 PilZ domain; Region: PilZ; pfam07238 272630001292 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 272630001293 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 272630001294 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 272630001295 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 272630001296 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 272630001297 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272630001298 Walker A motif; other site 272630001299 ATP binding site [chemical binding]; other site 272630001300 Walker B motif; other site 272630001301 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 272630001302 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272630001303 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 272630001304 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272630001305 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 272630001306 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 272630001307 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 272630001308 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272630001309 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 272630001310 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 272630001311 Flagellar protein FlaF; Region: FlaF; pfam07309 272630001312 flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794 272630001313 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 272630001314 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 272630001315 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK12781 272630001316 flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792 272630001317 FHIPEP family; Region: FHIPEP; pfam00771 272630001318 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK12780 272630001319 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 272630001320 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 272630001321 inhibitor site; inhibition site 272630001322 active site 272630001323 dimer interface [polypeptide binding]; other site 272630001324 catalytic residue [active] 272630001325 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 272630001326 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272630001327 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272630001328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630001329 putative active site [active] 272630001330 heme pocket [chemical binding]; other site 272630001331 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630001332 dimer interface [polypeptide binding]; other site 272630001333 phosphorylation site [posttranslational modification] 272630001334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630001335 ATP binding site [chemical binding]; other site 272630001336 Mg2+ binding site [ion binding]; other site 272630001337 G-X-G motif; other site 272630001338 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272630001339 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 272630001340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630001341 Predicted transcriptional regulators [Transcription]; Region: COG1733 272630001342 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272630001343 Transglycosylase; Region: Transgly; pfam00912 272630001344 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272630001345 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272630001346 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 272630001347 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630001348 dimer interface [polypeptide binding]; other site 272630001349 putative CheW interface [polypeptide binding]; other site 272630001350 AMP nucleosidase; Provisional; Region: PRK08292 272630001351 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 272630001352 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 272630001353 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 272630001354 homodimer interaction site [polypeptide binding]; other site 272630001355 cofactor binding site; other site 272630001356 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 272630001357 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 272630001358 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 272630001359 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 272630001360 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 272630001361 putative active site [active] 272630001362 Zn binding site [ion binding]; other site 272630001363 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 272630001364 ligand binding site; other site 272630001365 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 272630001366 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272630001367 ethanolamine permease; Region: 2A0305; TIGR00908 272630001368 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 272630001369 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 272630001370 catalytic triad [active] 272630001371 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272630001372 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272630001373 active site 272630001374 catalytic tetrad [active] 272630001375 hypothetical protein; Provisional; Region: PRK07236 272630001376 hypothetical protein; Validated; Region: PRK05868 272630001377 Predicted membrane protein [Function unknown]; Region: COG1238 272630001378 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 272630001379 Putative ParB-like nuclease; Region: ParBc_2; cl17538 272630001380 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272630001381 EVE domain; Region: EVE; pfam01878 272630001382 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 272630001383 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272630001384 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272630001385 PAS domain; Region: PAS_9; pfam13426 272630001386 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630001387 putative active site [active] 272630001388 heme pocket [chemical binding]; other site 272630001389 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630001390 PAS domain; Region: PAS_9; pfam13426 272630001391 putative active site [active] 272630001392 heme pocket [chemical binding]; other site 272630001393 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630001394 dimer interface [polypeptide binding]; other site 272630001395 putative CheW interface [polypeptide binding]; other site 272630001396 UGMP family protein; Validated; Region: PRK09604 272630001397 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 272630001398 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 272630001399 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 272630001400 active site 272630001401 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 272630001402 HemY protein N-terminus; Region: HemY_N; pfam07219 272630001403 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 272630001404 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630001405 dimer interface [polypeptide binding]; other site 272630001406 putative CheW interface [polypeptide binding]; other site 272630001407 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272630001408 DEAD/DEAH box helicase; Region: DEAD; pfam00270 272630001409 ATP binding site [chemical binding]; other site 272630001410 putative Mg++ binding site [ion binding]; other site 272630001411 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630001412 nucleotide binding region [chemical binding]; other site 272630001413 ATP-binding site [chemical binding]; other site 272630001414 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 272630001415 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 272630001416 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 272630001417 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 272630001418 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 272630001419 RNA binding site [nucleotide binding]; other site 272630001420 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272630001421 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272630001422 Walker A/P-loop; other site 272630001423 ATP binding site [chemical binding]; other site 272630001424 Q-loop/lid; other site 272630001425 ABC transporter signature motif; other site 272630001426 Walker B; other site 272630001427 D-loop; other site 272630001428 H-loop/switch region; other site 272630001429 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 272630001430 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 272630001431 FHIPEP family; Region: FHIPEP; pfam00771 272630001432 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 272630001433 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 272630001434 dimerization interface [polypeptide binding]; other site 272630001435 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 272630001436 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630001437 dimer interface [polypeptide binding]; other site 272630001438 putative CheW interface [polypeptide binding]; other site 272630001439 Predicted integral membrane protein [Function unknown]; Region: COG0392 272630001440 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 272630001441 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 272630001442 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272630001443 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 272630001444 Walker A motif/ATP binding site; other site 272630001445 Walker B motif; other site 272630001446 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272630001447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630001448 active site 272630001449 phosphorylation site [posttranslational modification] 272630001450 intermolecular recognition site; other site 272630001451 dimerization interface [polypeptide binding]; other site 272630001452 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630001453 DNA binding site [nucleotide binding] 272630001454 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 272630001455 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 272630001456 trimer interface [polypeptide binding]; other site 272630001457 active site 272630001458 substrate binding site [chemical binding]; other site 272630001459 CoA binding site [chemical binding]; other site 272630001460 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 272630001461 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272630001462 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 272630001463 putative NAD(P) binding site [chemical binding]; other site 272630001464 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 272630001465 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 272630001466 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272630001467 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272630001468 Probable Catalytic site; other site 272630001469 metal-binding site 272630001470 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630001471 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 272630001472 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630001473 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 272630001474 hypothetical protein; Validated; Region: PRK09104 272630001475 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 272630001476 metal binding site [ion binding]; metal-binding site 272630001477 putative dimer interface [polypeptide binding]; other site 272630001478 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 272630001479 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 272630001480 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 272630001481 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 272630001482 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 272630001483 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 272630001484 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 272630001485 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272630001486 camphor resistance protein CrcB; Provisional; Region: PRK14198 272630001487 Predicted membrane protein [Function unknown]; Region: COG2510 272630001488 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 272630001489 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272630001490 MarR family; Region: MarR_2; pfam12802 272630001491 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272630001492 active site 272630001493 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272630001494 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272630001495 Probable Catalytic site; other site 272630001496 metal-binding site 272630001497 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 272630001498 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 272630001499 substrate binding site; other site 272630001500 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 272630001501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630001502 NAD(P) binding site [chemical binding]; other site 272630001503 active site 272630001504 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 272630001505 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272630001506 Methyltransferase domain; Region: Methyltransf_12; pfam08242 272630001507 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 272630001508 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 272630001509 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272630001510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630001511 NAD(P) binding site [chemical binding]; other site 272630001512 active site 272630001513 Response regulator receiver domain; Region: Response_reg; pfam00072 272630001514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630001515 active site 272630001516 phosphorylation site [posttranslational modification] 272630001517 intermolecular recognition site; other site 272630001518 dimerization interface [polypeptide binding]; other site 272630001519 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 272630001520 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272630001521 inhibitor-cofactor binding pocket; inhibition site 272630001522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630001523 catalytic residue [active] 272630001524 glycine dehydrogenase; Provisional; Region: PRK05367 272630001525 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272630001526 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272630001527 catalytic residue [active] 272630001528 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 272630001529 tetramer interface [polypeptide binding]; other site 272630001530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630001531 catalytic residue [active] 272630001532 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 272630001533 lipoyl attachment site [posttranslational modification]; other site 272630001534 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 272630001535 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272630001536 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 272630001537 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272630001538 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272630001539 catalytic residue [active] 272630001540 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272630001541 NlpC/P60 family; Region: NLPC_P60; pfam00877 272630001542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630001543 C factor cell-cell signaling protein; Provisional; Region: PRK09009 272630001544 NAD(P) binding site [chemical binding]; other site 272630001545 active site 272630001546 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 272630001547 MgtC family; Region: MgtC; pfam02308 272630001548 MoxR-like ATPases [General function prediction only]; Region: COG0714 272630001549 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 272630001550 Protein of unknown function DUF58; Region: DUF58; pfam01882 272630001551 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272630001552 metal ion-dependent adhesion site (MIDAS); other site 272630001553 von Willebrand factor type A domain; Region: VWA_2; pfam13519 272630001554 metal ion-dependent adhesion site (MIDAS); other site 272630001555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272630001556 TPR motif; other site 272630001557 binding surface 272630001558 TPR repeat; Region: TPR_11; pfam13414 272630001559 Oxygen tolerance; Region: BatD; pfam13584 272630001560 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 272630001561 putative heme binding pocket [chemical binding]; other site 272630001562 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272630001563 EamA-like transporter family; Region: EamA; pfam00892 272630001564 potential protein location (hypothetical protein) that overlaps protein (conserved hypothetical protein) 272630001565 potential protein location (conserved hypothetical protein) that overlaps protein (hypothetical protein) 272630001566 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 272630001567 putative active site; other site 272630001568 putative triphosphate binding site [ion binding]; other site 272630001569 methionine sulfoxide reductase B; Provisional; Region: PRK00222 272630001570 SelR domain; Region: SelR; pfam01641 272630001571 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 272630001572 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630001573 PAS domain; Region: PAS_9; pfam13426 272630001574 putative active site [active] 272630001575 heme pocket [chemical binding]; other site 272630001576 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630001577 PAS domain; Region: PAS_9; pfam13426 272630001578 putative active site [active] 272630001579 heme pocket [chemical binding]; other site 272630001580 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630001581 HWE histidine kinase; Region: HWE_HK; pfam07536 272630001582 malonyl-CoA synthase; Validated; Region: PRK07514 272630001583 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 272630001584 acyl-activating enzyme (AAE) consensus motif; other site 272630001585 active site 272630001586 AMP binding site [chemical binding]; other site 272630001587 CoA binding site [chemical binding]; other site 272630001588 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 272630001589 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272630001590 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 272630001591 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 272630001592 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 272630001593 intracellular protease, PfpI family; Region: PfpI; TIGR01382 272630001594 proposed catalytic triad [active] 272630001595 conserved cys residue [active] 272630001596 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272630001597 DNA-binding site [nucleotide binding]; DNA binding site 272630001598 RNA-binding motif; other site 272630001599 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 272630001600 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 272630001601 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 272630001602 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 272630001603 Permease; Region: Permease; pfam02405 272630001604 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 272630001605 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 272630001606 Walker A/P-loop; other site 272630001607 ATP binding site [chemical binding]; other site 272630001608 Q-loop/lid; other site 272630001609 ABC transporter signature motif; other site 272630001610 Walker B; other site 272630001611 D-loop; other site 272630001612 H-loop/switch region; other site 272630001613 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 272630001614 mce related protein; Region: MCE; pfam02470 272630001615 Protein of unknown function (DUF330); Region: DUF330; cl01135 272630001616 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 272630001617 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272630001618 active site 272630001619 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 272630001620 Ribosome modulation factor; Region: RMF; cl01207 272630001621 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 272630001622 UbiA prenyltransferase family; Region: UbiA; pfam01040 272630001623 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 272630001624 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 272630001625 active site 272630001626 homotetramer interface [polypeptide binding]; other site 272630001627 homodimer interface [polypeptide binding]; other site 272630001628 glutamate--cysteine ligase; Region: PLN02611 272630001629 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 272630001630 CPxP motif; other site 272630001631 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272630001632 dimer interface [polypeptide binding]; other site 272630001633 ADP-ribose binding site [chemical binding]; other site 272630001634 active site 272630001635 nudix motif; other site 272630001636 metal binding site [ion binding]; metal-binding site 272630001637 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 272630001638 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 272630001639 primary metal binding site; other site 272630001640 catalytic residues [active] 272630001641 Predicted aspartyl protease [General function prediction only]; Region: COG3577 272630001642 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 272630001643 catalytic motif [active] 272630001644 Catalytic residue [active] 272630001645 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 272630001646 cobalamin synthase; Reviewed; Region: cobS; PRK00235 272630001647 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 272630001648 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 272630001649 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 272630001650 putative dimer interface [polypeptide binding]; other site 272630001651 active site pocket [active] 272630001652 putative cataytic base [active] 272630001653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630001654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630001655 dimer interface [polypeptide binding]; other site 272630001656 phosphorylation site [posttranslational modification] 272630001657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630001658 ATP binding site [chemical binding]; other site 272630001659 Mg2+ binding site [ion binding]; other site 272630001660 G-X-G motif; other site 272630001661 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 272630001662 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272630001663 catalytic loop [active] 272630001664 iron binding site [ion binding]; other site 272630001665 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 272630001666 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 272630001667 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 272630001668 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272630001669 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272630001670 PAS domain; Region: PAS_9; pfam13426 272630001671 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272630001672 GAF domain; Region: GAF; pfam01590 272630001673 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272630001674 GAF domain; Region: GAF; cl17456 272630001675 PAS domain; Region: PAS_9; pfam13426 272630001676 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630001677 putative active site [active] 272630001678 heme pocket [chemical binding]; other site 272630001679 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272630001680 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272630001681 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630001682 PAS fold; Region: PAS_3; pfam08447 272630001683 putative active site [active] 272630001684 heme pocket [chemical binding]; other site 272630001685 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630001686 HWE histidine kinase; Region: HWE_HK; smart00911 272630001687 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 272630001688 Amidase; Region: Amidase; cl11426 272630001689 Amidase; Region: Amidase; cl11426 272630001690 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 272630001691 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 272630001692 B1 nucleotide binding pocket [chemical binding]; other site 272630001693 B2 nucleotide binding pocket [chemical binding]; other site 272630001694 CAS motifs; other site 272630001695 active site 272630001696 Protein of unknown function (DUF519); Region: DUF519; pfam04378 272630001697 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 272630001698 FAD binding domain; Region: FAD_binding_4; pfam01565 272630001699 Cytochrome c; Region: Cytochrom_C; cl11414 272630001700 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272630001701 MarR family; Region: MarR; pfam01047 272630001702 Predicted integral membrane protein [Function unknown]; Region: COG5436 272630001703 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 272630001704 Transglycosylase; Region: Transgly; pfam00912 272630001705 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272630001706 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272630001707 hypothetical protein; Provisional; Region: PRK05170 272630001708 TadE-like protein; Region: TadE; pfam07811 272630001709 Predicted ATPase [General function prediction only]; Region: COG1485 272630001710 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 272630001711 active site 272630001712 DNA binding site [nucleotide binding] 272630001713 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 272630001714 RNA/DNA hybrid binding site [nucleotide binding]; other site 272630001715 active site 272630001716 glutathione synthetase; Provisional; Region: PRK05246 272630001717 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 272630001718 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 272630001719 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 272630001720 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 272630001721 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 272630001722 amidase catalytic site [active] 272630001723 Zn binding residues [ion binding]; other site 272630001724 substrate binding site [chemical binding]; other site 272630001725 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272630001726 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 272630001727 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 272630001728 putative metal binding site [ion binding]; other site 272630001729 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272630001730 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 272630001731 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272630001732 FMN binding site [chemical binding]; other site 272630001733 active site 272630001734 catalytic residues [active] 272630001735 substrate binding site [chemical binding]; other site 272630001736 PAS fold; Region: PAS_7; pfam12860 272630001737 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630001738 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630001739 metal binding site [ion binding]; metal-binding site 272630001740 active site 272630001741 I-site; other site 272630001742 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630001743 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 272630001744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630001745 active site 272630001746 phosphorylation site [posttranslational modification] 272630001747 intermolecular recognition site; other site 272630001748 dimerization interface [polypeptide binding]; other site 272630001749 Sensors of blue-light using FAD; Region: BLUF; pfam04940 272630001750 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 272630001751 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272630001752 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 272630001753 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272630001754 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 272630001755 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272630001756 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 272630001757 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 272630001758 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 272630001759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630001760 S-adenosylmethionine binding site [chemical binding]; other site 272630001761 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272630001762 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272630001763 RF-1 domain; Region: RF-1; pfam00472 272630001764 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 272630001765 GAF domain; Region: GAF; pfam01590 272630001766 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 272630001767 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 272630001768 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272630001769 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272630001770 aspartate kinase; Reviewed; Region: PRK06635 272630001771 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 272630001772 putative nucleotide binding site [chemical binding]; other site 272630001773 putative catalytic residues [active] 272630001774 putative Mg ion binding site [ion binding]; other site 272630001775 putative aspartate binding site [chemical binding]; other site 272630001776 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 272630001777 putative allosteric regulatory site; other site 272630001778 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 272630001779 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 272630001780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630001781 S-adenosylmethionine binding site [chemical binding]; other site 272630001782 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 272630001783 substrate binding site [chemical binding]; other site 272630001784 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 272630001785 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 272630001786 NAD(P) binding site [chemical binding]; other site 272630001787 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 272630001788 active site 272630001789 putative DNA-binding cleft [nucleotide binding]; other site 272630001790 dimer interface [polypeptide binding]; other site 272630001791 Uncharacterized conserved protein [Function unknown]; Region: COG2353 272630001792 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 272630001793 RuvA N terminal domain; Region: RuvA_N; pfam01330 272630001794 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 272630001795 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630001796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630001797 active site 272630001798 phosphorylation site [posttranslational modification] 272630001799 intermolecular recognition site; other site 272630001800 dimerization interface [polypeptide binding]; other site 272630001801 Predicted transcriptional regulator [Transcription]; Region: COG1959 272630001802 Transcriptional regulator; Region: Rrf2; cl17282 272630001803 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 272630001804 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 272630001805 heme-binding site [chemical binding]; other site 272630001806 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 272630001807 FAD binding pocket [chemical binding]; other site 272630001808 FAD binding motif [chemical binding]; other site 272630001809 phosphate binding motif [ion binding]; other site 272630001810 beta-alpha-beta structure motif; other site 272630001811 NAD binding pocket [chemical binding]; other site 272630001812 Heme binding pocket [chemical binding]; other site 272630001813 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272630001814 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272630001815 dimer interface [polypeptide binding]; other site 272630001816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630001817 catalytic residue [active] 272630001818 META domain; Region: META; pfam03724 272630001819 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 272630001820 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272630001821 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272630001822 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630001823 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630001824 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 272630001825 putative dimerization interface [polypeptide binding]; other site 272630001826 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 272630001827 metal binding site [ion binding]; metal-binding site 272630001828 active site 272630001829 phosphoribulokinase; Provisional; Region: PRK15453 272630001830 active site 272630001831 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 272630001832 hypothetical protein; Validated; Region: PRK00110 272630001833 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272630001834 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 272630001835 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 272630001836 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272630001837 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 272630001838 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 272630001839 oxyanion hole [active] 272630001840 OpgC protein; Region: OpgC_C; pfam10129 272630001841 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272630001842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272630001843 motif II; other site 272630001844 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 272630001845 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272630001846 substrate binding site [chemical binding]; other site 272630001847 hexamer interface [polypeptide binding]; other site 272630001848 metal binding site [ion binding]; metal-binding site 272630001849 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 272630001850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272630001851 Coenzyme A binding pocket [chemical binding]; other site 272630001852 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 272630001853 ornithine decarboxylase; Provisional; Region: PRK13578 272630001854 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272630001855 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272630001856 catalytic residue [active] 272630001857 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 272630001858 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 272630001859 MPT binding site; other site 272630001860 trimer interface [polypeptide binding]; other site 272630001861 adenylosuccinate lyase; Provisional; Region: PRK07492 272630001862 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 272630001863 tetramer interface [polypeptide binding]; other site 272630001864 active site 272630001865 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 272630001866 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 272630001867 homodimer interface [polypeptide binding]; other site 272630001868 substrate-cofactor binding pocket; other site 272630001869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630001870 catalytic residue [active] 272630001871 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 272630001872 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 272630001873 GDP-binding site [chemical binding]; other site 272630001874 ACT binding site; other site 272630001875 IMP binding site; other site 272630001876 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 272630001877 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272630001878 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630001879 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272630001880 DNA binding residues [nucleotide binding] 272630001881 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630001882 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630001883 metal binding site [ion binding]; metal-binding site 272630001884 active site 272630001885 I-site; other site 272630001886 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630001887 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272630001888 Coenzyme A binding pocket [chemical binding]; other site 272630001889 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 272630001890 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272630001891 RNA binding surface [nucleotide binding]; other site 272630001892 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272630001893 active site 272630001894 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 272630001895 GTPase/Zn-binding domain interface [polypeptide binding]; other site 272630001896 GTP/Mg2+ binding site [chemical binding]; other site 272630001897 G4 box; other site 272630001898 G5 box; other site 272630001899 G1 box; other site 272630001900 Switch I region; other site 272630001901 G2 box; other site 272630001902 G3 box; other site 272630001903 Switch II region; other site 272630001904 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272630001905 Peptidase family M23; Region: Peptidase_M23; pfam01551 272630001906 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 272630001907 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 272630001908 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 272630001909 active site 272630001910 HIGH motif; other site 272630001911 nucleotide binding site [chemical binding]; other site 272630001912 active site 272630001913 KMSKS motif; other site 272630001914 heat shock protein 90; Provisional; Region: PRK05218 272630001915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630001916 ATP binding site [chemical binding]; other site 272630001917 Mg2+ binding site [ion binding]; other site 272630001918 G-X-G motif; other site 272630001919 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 272630001920 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 272630001921 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 272630001922 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 272630001923 DAK2 domain; Region: Dak2; pfam02734 272630001924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630001925 S-adenosylmethionine binding site [chemical binding]; other site 272630001926 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 272630001927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630001928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630001929 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 272630001930 active site 272630001931 putative homodimer interface [polypeptide binding]; other site 272630001932 SAM binding site [chemical binding]; other site 272630001933 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 272630001934 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 272630001935 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 272630001936 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630001937 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630001938 metal binding site [ion binding]; metal-binding site 272630001939 active site 272630001940 I-site; other site 272630001941 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630001942 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630001943 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272630001944 dimerization interface [polypeptide binding]; other site 272630001945 Predicted membrane protein [Function unknown]; Region: COG4125 272630001946 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 272630001947 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 272630001948 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 272630001949 active site 272630001950 SAM binding site [chemical binding]; other site 272630001951 homodimer interface [polypeptide binding]; other site 272630001952 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 272630001953 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272630001954 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 272630001955 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272630001956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630001957 non-specific DNA binding site [nucleotide binding]; other site 272630001958 salt bridge; other site 272630001959 sequence-specific DNA binding site [nucleotide binding]; other site 272630001960 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 272630001961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630001962 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272630001963 putative substrate translocation pore; other site 272630001964 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 272630001965 Bacterial sugar transferase; Region: Bac_transf; pfam02397 272630001966 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272630001967 metal binding site 2 [ion binding]; metal-binding site 272630001968 putative DNA binding helix; other site 272630001969 metal binding site 1 [ion binding]; metal-binding site 272630001970 dimer interface [polypeptide binding]; other site 272630001971 structural Zn2+ binding site [ion binding]; other site 272630001972 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272630001973 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272630001974 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 272630001975 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 272630001976 ABC-ATPase subunit interface; other site 272630001977 dimer interface [polypeptide binding]; other site 272630001978 putative PBP binding regions; other site 272630001979 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 272630001980 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 272630001981 putative active site [active] 272630001982 putative PHP Thumb interface [polypeptide binding]; other site 272630001983 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272630001984 generic binding surface II; other site 272630001985 generic binding surface I; other site 272630001986 lytic murein transglycosylase; Region: MltB_2; TIGR02283 272630001987 murein hydrolase B; Provisional; Region: PRK10760; cl17906 272630001988 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 272630001989 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 272630001990 putative active site pocket [active] 272630001991 dimerization interface [polypeptide binding]; other site 272630001992 putative catalytic residue [active] 272630001993 Recombination protein O N terminal; Region: RecO_N; pfam11967 272630001994 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 272630001995 Recombination protein O C terminal; Region: RecO_C; pfam02565 272630001996 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 272630001997 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272630001998 CAP-like domain; other site 272630001999 active site 272630002000 primary dimer interface [polypeptide binding]; other site 272630002001 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272630002002 rRNA binding site [nucleotide binding]; other site 272630002003 predicted 30S ribosome binding site; other site 272630002004 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 272630002005 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 272630002006 dimerization interface [polypeptide binding]; other site 272630002007 ligand binding site [chemical binding]; other site 272630002008 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 272630002009 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 272630002010 XdhC Rossmann domain; Region: XdhC_C; pfam13478 272630002011 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 272630002012 MPT binding site; other site 272630002013 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 272630002014 Ligand binding site; other site 272630002015 metal-binding site 272630002016 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 272630002017 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 272630002018 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 272630002019 active site 272630002020 cosubstrate binding site; other site 272630002021 substrate binding site [chemical binding]; other site 272630002022 catalytic site [active] 272630002023 Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911 272630002024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630002025 active site 272630002026 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 272630002027 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272630002028 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272630002029 Walker A/P-loop; other site 272630002030 ATP binding site [chemical binding]; other site 272630002031 Q-loop/lid; other site 272630002032 ABC transporter signature motif; other site 272630002033 Walker B; other site 272630002034 D-loop; other site 272630002035 H-loop/switch region; other site 272630002036 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 272630002037 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272630002038 FtsX-like permease family; Region: FtsX; pfam02687 272630002039 prolyl-tRNA synthetase; Provisional; Region: PRK12325 272630002040 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 272630002041 dimer interface [polypeptide binding]; other site 272630002042 motif 1; other site 272630002043 active site 272630002044 motif 2; other site 272630002045 motif 3; other site 272630002046 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 272630002047 anticodon binding site; other site 272630002048 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 272630002049 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272630002050 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 272630002051 dimer interface [polypeptide binding]; other site 272630002052 substrate binding site [chemical binding]; other site 272630002053 metal binding site [ion binding]; metal-binding site 272630002054 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272630002055 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272630002056 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 272630002057 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 272630002058 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 272630002059 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 272630002060 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 272630002061 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272630002062 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 272630002063 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272630002064 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 272630002065 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 272630002066 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272630002067 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 272630002068 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 272630002069 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 272630002070 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 272630002071 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 272630002072 4Fe-4S binding domain; Region: Fer4; pfam00037 272630002073 4Fe-4S binding domain; Region: Fer4; pfam00037 272630002074 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 272630002075 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 272630002076 NADH dehydrogenase subunit G; Validated; Region: PRK09130 272630002077 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272630002078 catalytic loop [active] 272630002079 iron binding site [ion binding]; other site 272630002080 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 272630002081 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272630002082 molybdopterin cofactor binding site; other site 272630002083 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 272630002084 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 272630002085 SLBB domain; Region: SLBB; pfam10531 272630002086 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 272630002087 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 272630002088 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 272630002089 putative dimer interface [polypeptide binding]; other site 272630002090 [2Fe-2S] cluster binding site [ion binding]; other site 272630002091 Uncharacterized conserved protein [Function unknown]; Region: COG3743 272630002092 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 272630002093 NADH dehydrogenase subunit D; Validated; Region: PRK06075 272630002094 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 272630002095 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 272630002096 NADH dehydrogenase subunit B; Validated; Region: PRK06411 272630002097 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 272630002098 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 272630002099 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 272630002100 pseudoazurin; Region: pseudoazurin; TIGR02375 272630002101 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 272630002102 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272630002103 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272630002104 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 272630002105 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272630002106 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272630002107 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 272630002108 IMP binding site; other site 272630002109 dimer interface [polypeptide binding]; other site 272630002110 partial ornithine binding site; other site 272630002111 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272630002112 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272630002113 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272630002114 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 272630002115 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 272630002116 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272630002117 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272630002118 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272630002119 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630002120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630002121 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272630002122 putative effector binding pocket; other site 272630002123 dimerization interface [polypeptide binding]; other site 272630002124 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 272630002125 Dehydroquinase class II; Region: DHquinase_II; pfam01220 272630002126 trimer interface [polypeptide binding]; other site 272630002127 active site 272630002128 dimer interface [polypeptide binding]; other site 272630002129 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 272630002130 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272630002131 carboxyltransferase (CT) interaction site; other site 272630002132 biotinylation site [posttranslational modification]; other site 272630002133 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 272630002134 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272630002135 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272630002136 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272630002137 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 272630002138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272630002139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272630002140 WHG domain; Region: WHG; pfam13305 272630002141 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 272630002142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 272630002143 NADH dehydrogenase; Validated; Region: PRK08183 272630002144 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 272630002145 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 272630002146 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 272630002147 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 272630002148 active site 272630002149 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 272630002150 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 272630002151 TSCPD domain; Region: TSCPD; pfam12637 272630002152 cyclase homology domain; Region: CHD; cd07302 272630002153 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272630002154 nucleotidyl binding site; other site 272630002155 metal binding site [ion binding]; metal-binding site 272630002156 dimer interface [polypeptide binding]; other site 272630002157 cyclase homology domain; Region: CHD; cd07302 272630002158 cyclase homology domain; Region: CHD; cd07302 272630002159 nucleotidyl binding site; other site 272630002160 metal binding site [ion binding]; metal-binding site 272630002161 dimer interface [polypeptide binding]; other site 272630002162 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272630002163 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 272630002164 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272630002165 putative active site [active] 272630002166 putative metal binding site [ion binding]; other site 272630002167 Domain of unknown function (DUF892); Region: DUF892; cl17410 272630002168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 272630002169 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 272630002170 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 272630002171 Cellulose synthase-like protein; Region: PLN02893 272630002172 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 272630002173 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 272630002174 DXD motif; other site 272630002175 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 272630002176 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630002177 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 272630002178 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272630002179 HlyD family secretion protein; Region: HlyD; pfam00529 272630002180 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630002181 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 272630002182 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 272630002183 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272630002184 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272630002185 dimerization interface [polypeptide binding]; other site 272630002186 putative Zn2+ binding site [ion binding]; other site 272630002187 putative DNA binding site [nucleotide binding]; other site 272630002188 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272630002189 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272630002190 Walker A/P-loop; other site 272630002191 ATP binding site [chemical binding]; other site 272630002192 Q-loop/lid; other site 272630002193 ABC transporter signature motif; other site 272630002194 Walker B; other site 272630002195 D-loop; other site 272630002196 H-loop/switch region; other site 272630002197 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272630002198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630002199 dimer interface [polypeptide binding]; other site 272630002200 conserved gate region; other site 272630002201 putative PBP binding loops; other site 272630002202 ABC-ATPase subunit interface; other site 272630002203 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272630002204 NMT1-like family; Region: NMT1_2; pfam13379 272630002205 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 272630002206 Rubredoxin; Region: Rubredoxin; pfam00301 272630002207 iron binding site [ion binding]; other site 272630002208 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 272630002209 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272630002210 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272630002211 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272630002212 OsmC-like protein; Region: OsmC; pfam02566 272630002213 Nif-specific regulatory protein; Region: nifA; TIGR01817 272630002214 GAF domain; Region: GAF; pfam01590 272630002215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630002216 Walker A motif; other site 272630002217 ATP binding site [chemical binding]; other site 272630002218 Walker B motif; other site 272630002219 arginine finger; other site 272630002220 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272630002221 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 272630002222 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 272630002223 conserved cys residue [active] 272630002224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272630002225 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 272630002226 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 272630002227 conserved cys residue [active] 272630002228 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 272630002229 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 272630002230 Na binding site [ion binding]; other site 272630002231 Protein of unknown function, DUF485; Region: DUF485; pfam04341 272630002232 Predicted amidohydrolase [General function prediction only]; Region: COG0388 272630002233 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 272630002234 putative active site [active] 272630002235 catalytic triad [active] 272630002236 putative dimer interface [polypeptide binding]; other site 272630002237 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630002238 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630002239 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272630002240 dimerization interface [polypeptide binding]; other site 272630002241 RNA polymerase sigma factor; Provisional; Region: PRK12547 272630002242 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630002243 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272630002244 DNA binding residues [nucleotide binding] 272630002245 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272630002246 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630002247 non-specific DNA binding site [nucleotide binding]; other site 272630002248 salt bridge; other site 272630002249 sequence-specific DNA binding site [nucleotide binding]; other site 272630002250 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 272630002251 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 272630002252 Walker A/P-loop; other site 272630002253 ATP binding site [chemical binding]; other site 272630002254 Q-loop/lid; other site 272630002255 ABC transporter signature motif; other site 272630002256 Walker B; other site 272630002257 D-loop; other site 272630002258 H-loop/switch region; other site 272630002259 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272630002260 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272630002261 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630002262 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 272630002263 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 272630002264 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 272630002265 DXD motif; other site 272630002266 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272630002267 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 272630002268 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630002269 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272630002270 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272630002271 Walker A/P-loop; other site 272630002272 ATP binding site [chemical binding]; other site 272630002273 Q-loop/lid; other site 272630002274 ABC transporter signature motif; other site 272630002275 Walker B; other site 272630002276 D-loop; other site 272630002277 H-loop/switch region; other site 272630002278 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272630002279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630002280 dimer interface [polypeptide binding]; other site 272630002281 conserved gate region; other site 272630002282 putative PBP binding loops; other site 272630002283 ABC-ATPase subunit interface; other site 272630002284 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272630002285 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 272630002286 substrate binding pocket [chemical binding]; other site 272630002287 membrane-bound complex binding site; other site 272630002288 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 272630002289 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 272630002290 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 272630002291 active site 272630002292 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 272630002293 active site 272630002294 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 272630002295 dimer interface [polypeptide binding]; other site 272630002296 non-prolyl cis peptide bond; other site 272630002297 insertion regions; other site 272630002298 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272630002299 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272630002300 membrane-bound complex binding site; other site 272630002301 hinge residues; other site 272630002302 Cupin domain; Region: Cupin_2; cl17218 272630002303 serine acetyltransferase; Provisional; Region: cysE; PRK11132 272630002304 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 272630002305 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 272630002306 trimer interface [polypeptide binding]; other site 272630002307 active site 272630002308 substrate binding site [chemical binding]; other site 272630002309 CoA binding site [chemical binding]; other site 272630002310 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272630002311 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272630002312 ligand binding site [chemical binding]; other site 272630002313 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272630002314 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272630002315 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272630002316 catalytic residue [active] 272630002317 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 272630002318 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272630002319 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 272630002320 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 272630002321 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 272630002322 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272630002323 DNA-binding site [nucleotide binding]; DNA binding site 272630002324 RNA-binding motif; other site 272630002325 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 272630002326 GAF domain; Region: GAF; pfam01590 272630002327 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272630002328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630002329 PAS domain; Region: PAS_9; pfam13426 272630002330 putative active site [active] 272630002331 heme pocket [chemical binding]; other site 272630002332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630002333 PAS domain; Region: PAS_9; pfam13426 272630002334 putative active site [active] 272630002335 heme pocket [chemical binding]; other site 272630002336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630002337 PAS fold; Region: PAS_3; pfam08447 272630002338 putative active site [active] 272630002339 heme pocket [chemical binding]; other site 272630002340 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630002341 PAS fold; Region: PAS_3; pfam08447 272630002342 putative active site [active] 272630002343 heme pocket [chemical binding]; other site 272630002344 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630002345 PAS fold; Region: PAS_3; pfam08447 272630002346 putative active site [active] 272630002347 heme pocket [chemical binding]; other site 272630002348 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630002349 HWE histidine kinase; Region: HWE_HK; pfam07536 272630002350 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 272630002351 myosin-cross-reactive antigen; Provisional; Region: PRK13977 272630002352 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 272630002353 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 272630002354 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 272630002355 dimer interface [polypeptide binding]; other site 272630002356 catalytic residues [active] 272630002357 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 272630002358 UreF; Region: UreF; pfam01730 272630002359 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 272630002360 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 272630002361 alpha-gamma subunit interface [polypeptide binding]; other site 272630002362 beta-gamma subunit interface [polypeptide binding]; other site 272630002363 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 272630002364 alpha-beta subunit interface [polypeptide binding]; other site 272630002365 urease subunit alpha; Reviewed; Region: ureC; PRK13308 272630002366 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 272630002367 subunit interactions [polypeptide binding]; other site 272630002368 active site 272630002369 flap region; other site 272630002370 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272630002371 UreD urease accessory protein; Region: UreD; pfam01774 272630002372 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 272630002373 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 272630002374 putative ligand binding site [chemical binding]; other site 272630002375 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 272630002376 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 272630002377 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272630002378 N-terminal plug; other site 272630002379 ligand-binding site [chemical binding]; other site 272630002380 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 272630002381 SnoaL-like domain; Region: SnoaL_2; pfam12680 272630002382 OsmC-like protein; Region: OsmC; pfam02566 272630002383 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630002384 PAS domain; Region: PAS_9; pfam13426 272630002385 putative active site [active] 272630002386 heme pocket [chemical binding]; other site 272630002387 formyl-coenzyme A transferase; Provisional; Region: PRK05398 272630002388 CoA-transferase family III; Region: CoA_transf_3; pfam02515 272630002389 putative hydrolase; Provisional; Region: PRK11460 272630002390 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272630002391 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 272630002392 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272630002393 PYR/PP interface [polypeptide binding]; other site 272630002394 dimer interface [polypeptide binding]; other site 272630002395 TPP binding site [chemical binding]; other site 272630002396 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272630002397 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 272630002398 TPP-binding site; other site 272630002399 dimer interface [polypeptide binding]; other site 272630002400 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 272630002401 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 272630002402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630002403 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 272630002404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630002405 putative substrate translocation pore; other site 272630002406 FOG: CBS domain [General function prediction only]; Region: COG0517 272630002407 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272630002408 Zeta toxin; Region: Zeta_toxin; pfam06414 272630002409 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; cl17853 272630002410 formyl-coenzyme A transferase; Provisional; Region: PRK05398 272630002411 CoA-transferase family III; Region: CoA_transf_3; pfam02515 272630002412 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272630002413 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272630002414 DNA-binding site [nucleotide binding]; DNA binding site 272630002415 FCD domain; Region: FCD; pfam07729 272630002416 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 272630002417 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272630002418 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 272630002419 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 272630002420 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 272630002421 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 272630002422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630002423 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 272630002424 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 272630002425 active site 272630002426 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 272630002427 Ligand Binding Site [chemical binding]; other site 272630002428 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 272630002429 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272630002430 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272630002431 potential protein location (conserved hypothetical protein) that overlaps protein (Hypothetical protein) 272630002432 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 272630002433 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272630002434 active site 272630002435 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 272630002436 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630002437 putative ADP-binding pocket [chemical binding]; other site 272630002438 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272630002439 regulatory protein interface [polypeptide binding]; other site 272630002440 active site 272630002441 regulatory phosphorylation site [posttranslational modification]; other site 272630002442 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272630002443 active pocket/dimerization site; other site 272630002444 active site 272630002445 phosphorylation site [posttranslational modification] 272630002446 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 272630002447 active site 272630002448 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 272630002449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630002450 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630002451 dimerization interface [polypeptide binding]; other site 272630002452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630002453 dimer interface [polypeptide binding]; other site 272630002454 phosphorylation site [posttranslational modification] 272630002455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630002456 ATP binding site [chemical binding]; other site 272630002457 Mg2+ binding site [ion binding]; other site 272630002458 G-X-G motif; other site 272630002459 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272630002460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630002461 active site 272630002462 phosphorylation site [posttranslational modification] 272630002463 intermolecular recognition site; other site 272630002464 dimerization interface [polypeptide binding]; other site 272630002465 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630002466 DNA binding site [nucleotide binding] 272630002467 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 272630002468 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 272630002469 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 272630002470 GTP-binding protein LepA; Provisional; Region: PRK05433 272630002471 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272630002472 G1 box; other site 272630002473 putative GEF interaction site [polypeptide binding]; other site 272630002474 GTP/Mg2+ binding site [chemical binding]; other site 272630002475 Switch I region; other site 272630002476 G2 box; other site 272630002477 G3 box; other site 272630002478 Switch II region; other site 272630002479 G4 box; other site 272630002480 G5 box; other site 272630002481 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272630002482 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272630002483 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272630002484 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272630002485 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630002486 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 272630002487 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272630002488 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 272630002489 Transglycosylase; Region: Transgly; pfam00912 272630002490 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272630002491 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272630002492 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 272630002493 flagellin; Reviewed; Region: PRK12688 272630002494 flagellin; Reviewed; Region: PRK12688 272630002495 Flagellar protein FlbT; Region: FlbT; pfam07378 272630002496 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 272630002497 Predicted membrane protein [Function unknown]; Region: COG4763 272630002498 Acyltransferase family; Region: Acyl_transf_3; pfam01757 272630002499 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 272630002500 HD domain; Region: HD_5; pfam13487 272630002501 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 272630002502 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272630002503 Zn2+ binding site [ion binding]; other site 272630002504 Mg2+ binding site [ion binding]; other site 272630002505 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 272630002506 Putative phosphatase (DUF442); Region: DUF442; cl17385 272630002507 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272630002508 active site 272630002509 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 272630002510 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 272630002511 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 272630002512 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272630002513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630002514 active site 272630002515 phosphorylation site [posttranslational modification] 272630002516 intermolecular recognition site; other site 272630002517 dimerization interface [polypeptide binding]; other site 272630002518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630002519 Walker A motif; other site 272630002520 ATP binding site [chemical binding]; other site 272630002521 Walker B motif; other site 272630002522 arginine finger; other site 272630002523 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272630002524 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 272630002525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630002526 dimer interface [polypeptide binding]; other site 272630002527 phosphorylation site [posttranslational modification] 272630002528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630002529 ATP binding site [chemical binding]; other site 272630002530 Mg2+ binding site [ion binding]; other site 272630002531 G-X-G motif; other site 272630002532 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272630002533 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272630002534 Walker A/P-loop; other site 272630002535 ATP binding site [chemical binding]; other site 272630002536 Q-loop/lid; other site 272630002537 ABC transporter signature motif; other site 272630002538 Walker B; other site 272630002539 D-loop; other site 272630002540 H-loop/switch region; other site 272630002541 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272630002542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630002543 dimer interface [polypeptide binding]; other site 272630002544 conserved gate region; other site 272630002545 putative PBP binding loops; other site 272630002546 ABC-ATPase subunit interface; other site 272630002547 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272630002548 NMT1/THI5 like; Region: NMT1; pfam09084 272630002549 substrate binding pocket [chemical binding]; other site 272630002550 membrane-bound complex binding site; other site 272630002551 septum formation inhibitor; Reviewed; Region: minC; PRK05177 272630002552 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 272630002553 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 272630002554 Predicted membrane protein [Function unknown]; Region: COG4325 272630002555 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 272630002556 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 272630002557 G1 box; other site 272630002558 putative GEF interaction site [polypeptide binding]; other site 272630002559 GTP/Mg2+ binding site [chemical binding]; other site 272630002560 Switch I region; other site 272630002561 G2 box; other site 272630002562 G3 box; other site 272630002563 Switch II region; other site 272630002564 G4 box; other site 272630002565 G5 box; other site 272630002566 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 272630002567 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 272630002568 CHASE3 domain; Region: CHASE3; pfam05227 272630002569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 272630002570 dimerization interface [polypeptide binding]; other site 272630002571 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630002572 dimer interface [polypeptide binding]; other site 272630002573 putative CheW interface [polypeptide binding]; other site 272630002574 septum formation inhibitor; Reviewed; Region: minC; PRK05177 272630002575 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 272630002576 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 272630002577 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 272630002578 Switch I; other site 272630002579 Switch II; other site 272630002580 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 272630002581 Cytochrome P450; Region: p450; cl12078 272630002582 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 272630002583 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 272630002584 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 272630002585 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 272630002586 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 272630002587 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 272630002588 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 272630002589 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 272630002590 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272630002591 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272630002592 ATP binding site [chemical binding]; other site 272630002593 putative Mg++ binding site [ion binding]; other site 272630002594 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630002595 nucleotide binding region [chemical binding]; other site 272630002596 ATP-binding site [chemical binding]; other site 272630002597 TRCF domain; Region: TRCF; pfam03461 272630002598 urea transporter, Yersinia type; Region: urea_trans_yut; TIGR03441 272630002599 UreD urease accessory protein; Region: UreD; pfam01774 272630002600 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 272630002601 G1 box; other site 272630002602 GTP/Mg2+ binding site [chemical binding]; other site 272630002603 G2 box; other site 272630002604 Switch I region; other site 272630002605 Switch II region; other site 272630002606 G4 box; other site 272630002607 G5 box; other site 272630002608 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 272630002609 UreF; Region: UreF; pfam01730 272630002610 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 272630002611 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 272630002612 dimer interface [polypeptide binding]; other site 272630002613 catalytic residues [active] 272630002614 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636 272630002615 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 272630002616 urease subunit alpha; Reviewed; Region: ureC; PRK13207 272630002617 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 272630002618 subunit interactions [polypeptide binding]; other site 272630002619 active site 272630002620 flap region; other site 272630002621 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cl00533 272630002622 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 272630002623 alpha-gamma subunit interface [polypeptide binding]; other site 272630002624 beta-gamma subunit interface [polypeptide binding]; other site 272630002625 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272630002626 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 272630002627 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 272630002628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630002629 active site 272630002630 phosphorylation site [posttranslational modification] 272630002631 intermolecular recognition site; other site 272630002632 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 272630002633 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272630002634 multiple promoter invertase; Provisional; Region: mpi; PRK13413 272630002635 catalytic residues [active] 272630002636 catalytic nucleophile [active] 272630002637 Presynaptic Site I dimer interface [polypeptide binding]; other site 272630002638 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272630002639 Synaptic Flat tetramer interface [polypeptide binding]; other site 272630002640 Synaptic Site I dimer interface [polypeptide binding]; other site 272630002641 DNA binding site [nucleotide binding] 272630002642 Homeodomain-like domain; Region: HTH_23; pfam13384 272630002643 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 272630002644 KicB killing factor; Region: KicB; cl11468 272630002645 Protein of unknown function DUF72; Region: DUF72; pfam01904 272630002646 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 272630002647 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630002648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630002649 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272630002650 putative effector binding pocket; other site 272630002651 dimerization interface [polypeptide binding]; other site 272630002652 classical (c) SDRs; Region: SDR_c; cd05233 272630002653 short chain dehydrogenase; Provisional; Region: PRK07041 272630002654 NAD(P) binding site [chemical binding]; other site 272630002655 active site 272630002656 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 272630002657 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 272630002658 dimerization interface [polypeptide binding]; other site 272630002659 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272630002660 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 272630002661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 272630002662 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 272630002663 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272630002664 catalytic core [active] 272630002665 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 272630002666 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 272630002667 classical (c) SDRs; Region: SDR_c; cd05233 272630002668 NAD(P) binding site [chemical binding]; other site 272630002669 active site 272630002670 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 272630002671 potential frameshift: common BLAST hit: gi|218529508|ref|YP_002420324.1| multi-sensor hybrid histidine kinase 272630002672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630002673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630002674 ATP binding site [chemical binding]; other site 272630002675 G-X-G motif; other site 272630002676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630002677 Response regulator receiver domain; Region: Response_reg; pfam00072 272630002678 active site 272630002679 phosphorylation site [posttranslational modification] 272630002680 intermolecular recognition site; other site 272630002681 dimerization interface [polypeptide binding]; other site 272630002682 PAS domain S-box; Region: sensory_box; TIGR00229 272630002683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630002684 putative active site [active] 272630002685 heme pocket [chemical binding]; other site 272630002686 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272630002687 GAF domain; Region: GAF; pfam01590 272630002688 GAF domain; Region: GAF; pfam01590 272630002689 PAS fold; Region: PAS_4; pfam08448 272630002690 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630002691 putative active site [active] 272630002692 heme pocket [chemical binding]; other site 272630002693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630002694 dimer interface [polypeptide binding]; other site 272630002695 phosphorylation site [posttranslational modification] 272630002696 Cytochrome P450; Region: p450; cl12078 272630002697 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 272630002698 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630002699 PAS domain; Region: PAS_9; pfam13426 272630002700 putative active site [active] 272630002701 heme pocket [chemical binding]; other site 272630002702 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630002703 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630002704 metal binding site [ion binding]; metal-binding site 272630002705 active site 272630002706 I-site; other site 272630002707 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630002708 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 272630002709 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 272630002710 ApbE family; Region: ApbE; pfam02424 272630002711 FMN-binding domain; Region: FMN_bind; cl01081 272630002712 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 272630002713 4Fe-4S binding domain; Region: Fer4_5; pfam12801 272630002714 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 272630002715 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272630002716 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272630002717 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272630002718 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 272630002719 ligand binding site [chemical binding]; other site 272630002720 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272630002721 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272630002722 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272630002723 substrate binding pocket [chemical binding]; other site 272630002724 membrane-bound complex binding site; other site 272630002725 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 272630002726 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 272630002727 dimer interface [polypeptide binding]; other site 272630002728 Trp docking motif [polypeptide binding]; other site 272630002729 active site 272630002730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630002731 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272630002732 putative substrate translocation pore; other site 272630002733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630002734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 272630002735 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 272630002736 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 272630002737 short chain dehydrogenase; Provisional; Region: PRK06172 272630002738 classical (c) SDRs; Region: SDR_c; cd05233 272630002739 NAD(P) binding site [chemical binding]; other site 272630002740 active site 272630002741 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630002742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630002743 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272630002744 dimerization interface [polypeptide binding]; other site 272630002745 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 272630002746 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272630002747 Ligand Binding Site [chemical binding]; other site 272630002748 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272630002749 Ligand Binding Site [chemical binding]; other site 272630002750 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272630002751 Cytochrome c; Region: Cytochrom_C; pfam00034 272630002752 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272630002753 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272630002754 ligand binding site [chemical binding]; other site 272630002755 flexible hinge region; other site 272630002756 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272630002757 putative switch regulator; other site 272630002758 non-specific DNA interactions [nucleotide binding]; other site 272630002759 DNA binding site [nucleotide binding] 272630002760 sequence specific DNA binding site [nucleotide binding]; other site 272630002761 putative cAMP binding site [chemical binding]; other site 272630002762 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272630002763 Walker A/P-loop; other site 272630002764 ATP binding site [chemical binding]; other site 272630002765 ABC transporter; Region: ABC_tran; pfam00005 272630002766 Q-loop/lid; other site 272630002767 ABC transporter signature motif; other site 272630002768 Walker B; other site 272630002769 D-loop; other site 272630002770 H-loop/switch region; other site 272630002771 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272630002772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630002773 Walker A/P-loop; other site 272630002774 ATP binding site [chemical binding]; other site 272630002775 Q-loop/lid; other site 272630002776 ABC transporter signature motif; other site 272630002777 Walker B; other site 272630002778 D-loop; other site 272630002779 H-loop/switch region; other site 272630002780 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 272630002781 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 272630002782 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 272630002783 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272630002784 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272630002785 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272630002786 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272630002787 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 272630002788 Amidase; Region: Amidase; cl11426 272630002789 Response regulator receiver domain; Region: Response_reg; pfam00072 272630002790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630002791 active site 272630002792 phosphorylation site [posttranslational modification] 272630002793 intermolecular recognition site; other site 272630002794 dimerization interface [polypeptide binding]; other site 272630002795 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 272630002796 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 272630002797 DXD motif; other site 272630002798 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 272630002799 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 272630002800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 272630002801 TPR motif; other site 272630002802 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 272630002803 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 272630002804 putative NAD(P) binding site [chemical binding]; other site 272630002805 active site 272630002806 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272630002807 MFS_1 like family; Region: MFS_1_like; pfam12832 272630002808 primosome assembly protein PriA; Validated; Region: PRK05580 272630002809 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272630002810 ATP binding site [chemical binding]; other site 272630002811 putative Mg++ binding site [ion binding]; other site 272630002812 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 272630002813 short chain dehydrogenase; Provisional; Region: PRK07109 272630002814 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 272630002815 putative NAD(P) binding site [chemical binding]; other site 272630002816 active site 272630002817 Isochorismatase family; Region: Isochorismatase; pfam00857 272630002818 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272630002819 catalytic triad [active] 272630002820 conserved cis-peptide bond; other site 272630002821 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 272630002822 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272630002823 NAD binding site [chemical binding]; other site 272630002824 catalytic Zn binding site [ion binding]; other site 272630002825 structural Zn binding site [ion binding]; other site 272630002826 Predicted membrane protein [Function unknown]; Region: COG1289 272630002827 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 272630002828 short chain dehydrogenase; Provisional; Region: PRK06701 272630002829 NAD binding site [chemical binding]; other site 272630002830 metal binding site [ion binding]; metal-binding site 272630002831 active site 272630002832 short chain dehydrogenase; Provisional; Region: PRK06139 272630002833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630002834 NAD(P) binding site [chemical binding]; other site 272630002835 active site 272630002836 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 272630002837 ABC1 family; Region: ABC1; pfam03109 272630002838 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272630002839 active site 272630002840 ATP binding site [chemical binding]; other site 272630002841 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272630002842 putative Zn2+ binding site [ion binding]; other site 272630002843 putative DNA binding site [nucleotide binding]; other site 272630002844 sensor protein QseC; Provisional; Region: PRK10337 272630002845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630002846 dimer interface [polypeptide binding]; other site 272630002847 phosphorylation site [posttranslational modification] 272630002848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630002849 ATP binding site [chemical binding]; other site 272630002850 Mg2+ binding site [ion binding]; other site 272630002851 G-X-G motif; other site 272630002852 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 272630002853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630002854 active site 272630002855 phosphorylation site [posttranslational modification] 272630002856 intermolecular recognition site; other site 272630002857 dimerization interface [polypeptide binding]; other site 272630002858 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630002859 DNA binding site [nucleotide binding] 272630002860 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 272630002861 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 272630002862 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272630002863 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 272630002864 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 272630002865 catalytic residues [active] 272630002866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272630002867 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630002868 DsrE/DsrF-like family; Region: DrsE; cl00672 272630002869 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 272630002870 Predicted transporter component [General function prediction only]; Region: COG2391 272630002871 Sulphur transport; Region: Sulf_transp; pfam04143 272630002872 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272630002873 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 272630002874 active site residue [active] 272630002875 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272630002876 arsenical pump membrane protein; Provisional; Region: PRK15445 272630002877 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 272630002878 transmembrane helices; other site 272630002879 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 272630002880 ArsC family; Region: ArsC; pfam03960 272630002881 catalytic residues [active] 272630002882 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 272630002883 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272630002884 active site 272630002885 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272630002886 dimerization interface [polypeptide binding]; other site 272630002887 putative DNA binding site [nucleotide binding]; other site 272630002888 putative Zn2+ binding site [ion binding]; other site 272630002889 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 272630002890 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272630002891 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 272630002892 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 272630002893 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272630002894 Cl- selectivity filter; other site 272630002895 Cl- binding residues [ion binding]; other site 272630002896 pore gating glutamate residue; other site 272630002897 dimer interface [polypeptide binding]; other site 272630002898 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272630002899 catalytic core [active] 272630002900 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272630002901 catalytic core [active] 272630002902 Predicted membrane protein [Function unknown]; Region: COG2855 272630002903 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 272630002904 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 272630002905 gating phenylalanine in ion channel; other site 272630002906 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 272630002907 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 272630002908 Moco binding site; other site 272630002909 metal coordination site [ion binding]; other site 272630002910 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272630002911 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 272630002912 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 272630002913 structural tetrad; other site 272630002914 sulfite oxidase; Provisional; Region: PLN00177 272630002915 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 272630002916 Moco binding site; other site 272630002917 metal coordination site [ion binding]; other site 272630002918 Domain of unknown function (DUF202); Region: DUF202; cl09954 272630002919 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 272630002920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630002921 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 272630002922 putative dimerization interface [polypeptide binding]; other site 272630002923 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 272630002924 active site 272630002925 catalytic triad [active] 272630002926 oxyanion hole [active] 272630002927 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 272630002928 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 272630002929 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630002930 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272630002931 DNA binding residues [nucleotide binding] 272630002932 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 272630002933 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 272630002934 Domain of unknown function (DUF305); Region: DUF305; pfam03713 272630002935 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 272630002936 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272630002937 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272630002938 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 272630002939 high affinity sulphate transporter 1; Region: sulP; TIGR00815 272630002940 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272630002941 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272630002942 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272630002943 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272630002944 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 272630002945 ligand binding site [chemical binding]; other site 272630002946 flexible hinge region; other site 272630002947 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272630002948 putative switch regulator; other site 272630002949 non-specific DNA interactions [nucleotide binding]; other site 272630002950 DNA binding site [nucleotide binding] 272630002951 sequence specific DNA binding site [nucleotide binding]; other site 272630002952 putative cAMP binding site [chemical binding]; other site 272630002953 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272630002954 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272630002955 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272630002956 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272630002957 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272630002958 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272630002959 catalytic residues [active] 272630002960 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272630002961 active site 272630002962 metal binding site [ion binding]; metal-binding site 272630002963 HIRAN domain; Region: HIRAN; pfam08797 272630002964 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 272630002965 putative active site [active] 272630002966 putative metal binding site [ion binding]; other site 272630002967 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272630002968 active site 272630002969 DNA binding site [nucleotide binding] 272630002970 Int/Topo IB signature motif; other site 272630002971 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630002972 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272630002973 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 272630002974 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630002975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272630002976 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 272630002977 Putative zinc-finger; Region: zf-HC2; pfam13490 272630002978 RNA polymerase sigma factor; Provisional; Region: PRK12511 272630002979 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630002980 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272630002981 DNA binding residues [nucleotide binding] 272630002982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 272630002983 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272630002984 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630002985 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 272630002986 Protein of unknown function (DUF461); Region: DUF461; pfam04314 272630002987 Protein of unknown function (DUF461); Region: DUF461; pfam04314 272630002988 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 272630002989 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 272630002990 Cu(I) binding site [ion binding]; other site 272630002991 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272630002992 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272630002993 N-terminal plug; other site 272630002994 ligand-binding site [chemical binding]; other site 272630002995 Caspase domain; Region: Peptidase_C14; pfam00656 272630002996 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272630002997 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272630002998 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272630002999 DNA-binding site [nucleotide binding]; DNA binding site 272630003000 FCD domain; Region: FCD; pfam07729 272630003001 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 272630003002 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 272630003003 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 272630003004 DctM-like transporters; Region: DctM; pfam06808 272630003005 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 272630003006 similar to hypothetical protein; Evidence 6 : Doubtful CDS 272630003007 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272630003008 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272630003009 dimer interface [polypeptide binding]; other site 272630003010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630003011 catalytic residue [active] 272630003012 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 272630003013 Protein of unknown function, DUF606; Region: DUF606; pfam04657 272630003014 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 272630003015 MG2 domain; Region: A2M_N; pfam01835 272630003016 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 272630003017 surface patch; other site 272630003018 thioester region; other site 272630003019 specificity defining residues; other site 272630003020 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 272630003021 Transglycosylase; Region: Transgly; pfam00912 272630003022 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272630003023 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 272630003024 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 272630003025 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 272630003026 active site 272630003027 catalytic site [active] 272630003028 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 272630003029 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 272630003030 vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461 272630003031 metal ion-dependent adhesion site (MIDAS); other site 272630003032 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272630003033 catalytic core [active] 272630003034 High-affinity nickel-transport protein; Region: NicO; cl00964 272630003035 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 272630003036 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 272630003037 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 272630003038 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 272630003039 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 272630003040 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 272630003041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 272630003042 TPR motif; other site 272630003043 binding surface 272630003044 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 272630003045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630003046 ATP binding site [chemical binding]; other site 272630003047 Mg2+ binding site [ion binding]; other site 272630003048 G-X-G motif; other site 272630003049 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 272630003050 putative active site [active] 272630003051 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272630003052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630003053 active site 272630003054 phosphorylation site [posttranslational modification] 272630003055 intermolecular recognition site; other site 272630003056 dimerization interface [polypeptide binding]; other site 272630003057 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630003058 DNA binding site [nucleotide binding] 272630003059 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 272630003060 catalytic residues [active] 272630003061 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 272630003062 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 272630003063 Putative phage tail protein; Region: Phage-tail_3; pfam13550 272630003064 NlpC/P60 family; Region: NLPC_P60; cl17555 272630003065 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272630003066 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 272630003067 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 272630003068 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 272630003069 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 272630003070 Phage-related minor tail protein [Function unknown]; Region: COG5281 272630003071 Conserved hypothetical phage protein (DUF2376); Region: DUF2376; cl09774 272630003072 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 272630003073 Phage major tail protein 2; Region: Phage_tail_2; cl11463 272630003074 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 272630003075 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 272630003076 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 272630003077 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 272630003078 cleavage site 272630003079 active site 272630003080 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 272630003081 active site 272630003082 substrate binding sites [chemical binding]; other site 272630003083 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 272630003084 Phage capsid family; Region: Phage_capsid; pfam05065 272630003085 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 272630003086 Phage-related protein [Function unknown]; Region: COG4695 272630003087 Phage portal protein; Region: Phage_portal; pfam04860 272630003088 Uncharacterized conserved protein [Function unknown]; Region: COG5323 272630003089 Terminase-like family; Region: Terminase_6; pfam03237 272630003090 similar to hypothetical protein; Evidence 6 : Doubtful CDS 272630003091 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 272630003092 active site 272630003093 SAM binding site [chemical binding]; other site 272630003094 homodimer interface [polypeptide binding]; other site 272630003095 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 272630003096 active site 272630003097 SAM binding site [chemical binding]; other site 272630003098 homodimer interface [polypeptide binding]; other site 272630003099 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 272630003100 Precorrin-8X methylmutase; Region: CbiC; pfam02570 272630003101 precorrin-3B synthase; Region: CobG; TIGR02435 272630003102 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272630003103 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321 272630003104 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 272630003105 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 272630003106 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 272630003107 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 272630003108 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 272630003109 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 272630003110 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 272630003111 cobalt transporter subunit CbtA (proposed); Region: CbtA; TIGR02458 272630003112 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 272630003113 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 272630003114 MarR family; Region: MarR_2; pfam12802 272630003115 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 272630003116 homotrimer interface [polypeptide binding]; other site 272630003117 Walker A motif; other site 272630003118 GTP binding site [chemical binding]; other site 272630003119 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 272630003120 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 272630003121 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 272630003122 homodimer interface [polypeptide binding]; other site 272630003123 Walker A motif; other site 272630003124 ATP binding site [chemical binding]; other site 272630003125 hydroxycobalamin binding site [chemical binding]; other site 272630003126 Walker B motif; other site 272630003127 fumarate hydratase; Reviewed; Region: fumC; PRK00485 272630003128 Class II fumarases; Region: Fumarase_classII; cd01362 272630003129 active site 272630003130 tetramer interface [polypeptide binding]; other site 272630003131 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 272630003132 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272630003133 HAMP domain; Region: HAMP; pfam00672 272630003134 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630003135 dimer interface [polypeptide binding]; other site 272630003136 putative CheW interface [polypeptide binding]; other site 272630003137 EamA-like transporter family; Region: EamA; pfam00892 272630003138 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272630003139 EamA-like transporter family; Region: EamA; pfam00892 272630003140 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272630003141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272630003142 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 272630003143 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 272630003144 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 272630003145 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 272630003146 Protein of unknown function DUF58; Region: DUF58; pfam01882 272630003147 MoxR-like ATPases [General function prediction only]; Region: COG0714 272630003148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272630003149 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272630003150 CoenzymeA binding site [chemical binding]; other site 272630003151 subunit interaction site [polypeptide binding]; other site 272630003152 PHB binding site; other site 272630003153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 272630003154 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 272630003155 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 272630003156 putative active site [active] 272630003157 putative CoA binding site [chemical binding]; other site 272630003158 nudix motif; other site 272630003159 metal binding site [ion binding]; metal-binding site 272630003160 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 272630003161 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272630003162 active site 272630003163 NTP binding site [chemical binding]; other site 272630003164 metal binding triad [ion binding]; metal-binding site 272630003165 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272630003166 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14736 272630003167 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272630003168 gamma subunit interface [polypeptide binding]; other site 272630003169 epsilon subunit interface [polypeptide binding]; other site 272630003170 LBP interface [polypeptide binding]; other site 272630003171 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272630003172 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272630003173 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272630003174 alpha subunit interaction interface [polypeptide binding]; other site 272630003175 Walker A motif; other site 272630003176 ATP binding site [chemical binding]; other site 272630003177 Walker B motif; other site 272630003178 inhibitor binding site; inhibition site 272630003179 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272630003180 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272630003181 core domain interface [polypeptide binding]; other site 272630003182 delta subunit interface [polypeptide binding]; other site 272630003183 epsilon subunit interface [polypeptide binding]; other site 272630003184 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272630003185 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272630003186 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272630003187 beta subunit interaction interface [polypeptide binding]; other site 272630003188 Walker A motif; other site 272630003189 ATP binding site [chemical binding]; other site 272630003190 Walker B motif; other site 272630003191 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272630003192 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 272630003193 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 272630003194 ferrochelatase; Reviewed; Region: hemH; PRK00035 272630003195 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 272630003196 C-terminal domain interface [polypeptide binding]; other site 272630003197 active site 272630003198 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 272630003199 active site 272630003200 N-terminal domain interface [polypeptide binding]; other site 272630003201 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272630003202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630003203 S-adenosylmethionine binding site [chemical binding]; other site 272630003204 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272630003205 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272630003206 active site 272630003207 metal binding site [ion binding]; metal-binding site 272630003208 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272630003209 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 272630003210 ligand binding site [chemical binding]; other site 272630003211 active site 272630003212 UGI interface [polypeptide binding]; other site 272630003213 catalytic site [active] 272630003214 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 272630003215 active site residue [active] 272630003216 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 272630003217 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 272630003218 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 272630003219 Chromate transporter; Region: Chromate_transp; pfam02417 272630003220 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272630003221 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 272630003222 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272630003223 ATP binding site [chemical binding]; other site 272630003224 putative Mg++ binding site [ion binding]; other site 272630003225 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 272630003226 SEC-C motif; Region: SEC-C; pfam02810 272630003227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272630003228 Coenzyme A binding pocket [chemical binding]; other site 272630003229 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 272630003230 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272630003231 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 272630003232 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 272630003233 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272630003234 nudix motif; other site 272630003235 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 272630003236 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 272630003237 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 272630003238 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 272630003239 active site 272630003240 catalytic site [active] 272630003241 substrate binding site [chemical binding]; other site 272630003242 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 272630003243 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272630003244 CoA-binding site [chemical binding]; other site 272630003245 ATP-binding [chemical binding]; other site 272630003246 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 272630003247 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272630003248 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272630003249 shikimate binding site; other site 272630003250 NAD(P) binding site [chemical binding]; other site 272630003251 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 272630003252 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 272630003253 putative active site [active] 272630003254 Protein of unknown function (DUF563); Region: DUF563; pfam04577 272630003255 PEP synthetase regulatory protein; Provisional; Region: PRK05339 272630003256 uroporphyrinogen decarboxylase; Validated; Region: hemE; PRK00115 272630003257 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 272630003258 nudix motif; other site 272630003259 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 272630003260 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 272630003261 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 272630003262 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 272630003263 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 272630003264 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272630003265 active site 272630003266 dimer interface [polypeptide binding]; other site 272630003267 motif 2; other site 272630003268 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272630003269 active site 272630003270 motif 3; other site 272630003271 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 272630003272 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 272630003273 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 272630003274 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 272630003275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630003276 putative substrate translocation pore; other site 272630003277 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272630003278 putative acyl-acceptor binding pocket; other site 272630003279 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272630003280 acyl-activating enzyme (AAE) consensus motif; other site 272630003281 AMP binding site [chemical binding]; other site 272630003282 active site 272630003283 CoA binding site [chemical binding]; other site 272630003284 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 272630003285 Predicted transcriptional regulator [Transcription]; Region: COG2944 272630003286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630003287 non-specific DNA binding site [nucleotide binding]; other site 272630003288 salt bridge; other site 272630003289 sequence-specific DNA binding site [nucleotide binding]; other site 272630003290 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 272630003291 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272630003292 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 272630003293 diiron binding motif [ion binding]; other site 272630003294 Uncharacterized conserved protein [Function unknown]; Region: COG1633 272630003295 CCC1-related protein family; Region: CCC1_like_1; cd02437 272630003296 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 272630003297 trimer interface [polypeptide binding]; other site 272630003298 putative metal binding site [ion binding]; other site 272630003299 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 272630003300 trimer interface [polypeptide binding]; other site 272630003301 putative metal binding site [ion binding]; other site 272630003302 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 272630003303 MoaE homodimer interface [polypeptide binding]; other site 272630003304 MoaD interaction [polypeptide binding]; other site 272630003305 active site residues [active] 272630003306 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 272630003307 malate:quinone oxidoreductase; Validated; Region: PRK05257 272630003308 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 272630003309 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 272630003310 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272630003311 metal ion-dependent adhesion site (MIDAS); other site 272630003312 MoxR-like ATPases [General function prediction only]; Region: COG0714 272630003313 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 272630003314 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 272630003315 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 272630003316 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 272630003317 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 272630003318 putative uracil binding site [chemical binding]; other site 272630003319 putative active site [active] 272630003320 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 272630003321 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 272630003322 active site 272630003323 dimer interface [polypeptide binding]; other site 272630003324 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 272630003325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272630003326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272630003327 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272630003328 trimer interface [polypeptide binding]; other site 272630003329 active site 272630003330 Protein of unknown function (DUF429); Region: DUF429; cl12046 272630003331 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272630003332 nudix motif; other site 272630003333 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 272630003334 active site clefts [active] 272630003335 zinc binding site [ion binding]; other site 272630003336 dimer interface [polypeptide binding]; other site 272630003337 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272630003338 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 272630003339 active site 272630003340 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 272630003341 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272630003342 putative binding surface; other site 272630003343 active site 272630003344 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 272630003345 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 272630003346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630003347 ATP binding site [chemical binding]; other site 272630003348 Mg2+ binding site [ion binding]; other site 272630003349 G-X-G motif; other site 272630003350 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 272630003351 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630003352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630003353 active site 272630003354 phosphorylation site [posttranslational modification] 272630003355 intermolecular recognition site; other site 272630003356 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 272630003357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630003358 Response regulator receiver domain; Region: Response_reg; pfam00072 272630003359 active site 272630003360 phosphorylation site [posttranslational modification] 272630003361 intermolecular recognition site; other site 272630003362 dimerization interface [polypeptide binding]; other site 272630003363 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 272630003364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630003365 active site 272630003366 phosphorylation site [posttranslational modification] 272630003367 intermolecular recognition site; other site 272630003368 dimerization interface [polypeptide binding]; other site 272630003369 CheB methylesterase; Region: CheB_methylest; pfam01339 272630003370 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 272630003371 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 272630003372 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 272630003373 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 272630003374 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 272630003375 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 272630003376 UV-endonuclease UvdE; Region: UvdE; cl10036 272630003377 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 272630003378 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 272630003379 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 272630003380 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 272630003381 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 272630003382 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 272630003383 Ligand binding site [chemical binding]; other site 272630003384 Electron transfer flavoprotein domain; Region: ETF; pfam01012 272630003385 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 272630003386 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 272630003387 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 272630003388 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 272630003389 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272630003390 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272630003391 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 272630003392 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 272630003393 NAD(P) binding site [chemical binding]; other site 272630003394 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272630003395 active site 272630003396 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 272630003397 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 272630003398 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 272630003399 active site 272630003400 catalytic site [active] 272630003401 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 272630003402 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 272630003403 active site 272630003404 homotetramer interface [polypeptide binding]; other site 272630003405 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 272630003406 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 272630003407 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 272630003408 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 272630003409 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 272630003410 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272630003411 dimer interface [polypeptide binding]; other site 272630003412 motif 1; other site 272630003413 active site 272630003414 motif 2; other site 272630003415 motif 3; other site 272630003416 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 272630003417 anticodon binding site; other site 272630003418 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 272630003419 dimer interface [polypeptide binding]; other site 272630003420 putative tRNA-binding site [nucleotide binding]; other site 272630003421 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 272630003422 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272630003423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630003424 preprotein translocase subunit SecB; Validated; Region: PRK05751 272630003425 SecA binding site; other site 272630003426 Preprotein binding site; other site 272630003427 Tim44-like domain; Region: Tim44; pfam04280 272630003428 MltA specific insert domain; Region: MltA; smart00925 272630003429 3D domain; Region: 3D; pfam06725 272630003430 Smr domain; Region: Smr; pfam01713 272630003431 transcription termination factor Rho; Provisional; Region: rho; PRK09376 272630003432 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 272630003433 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 272630003434 RNA binding site [nucleotide binding]; other site 272630003435 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 272630003436 multimer interface [polypeptide binding]; other site 272630003437 Walker A motif; other site 272630003438 ATP binding site [chemical binding]; other site 272630003439 Walker B motif; other site 272630003440 pyruvate dehydrogenase; Provisional; Region: PRK09124 272630003441 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 272630003442 PYR/PP interface [polypeptide binding]; other site 272630003443 dimer interface [polypeptide binding]; other site 272630003444 tetramer interface [polypeptide binding]; other site 272630003445 TPP binding site [chemical binding]; other site 272630003446 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272630003447 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 272630003448 TPP-binding site [chemical binding]; other site 272630003449 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 272630003450 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272630003451 putative lipid kinase; Reviewed; Region: PRK13057 272630003452 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 272630003453 active site 272630003454 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272630003455 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272630003456 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630003457 non-specific DNA binding site [nucleotide binding]; other site 272630003458 salt bridge; other site 272630003459 sequence-specific DNA binding site [nucleotide binding]; other site 272630003460 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 272630003461 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 272630003462 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 272630003463 trimer interface [polypeptide binding]; other site 272630003464 active site 272630003465 substrate binding site [chemical binding]; other site 272630003466 CoA binding site [chemical binding]; other site 272630003467 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272630003468 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272630003469 ligand binding site [chemical binding]; other site 272630003470 flexible hinge region; other site 272630003471 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272630003472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630003473 active site 272630003474 phosphorylation site [posttranslational modification] 272630003475 intermolecular recognition site; other site 272630003476 dimerization interface [polypeptide binding]; other site 272630003477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630003478 DNA binding site [nucleotide binding] 272630003479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 272630003480 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 272630003481 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272630003482 catalytic residue [active] 272630003483 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272630003484 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272630003485 HIGH motif; other site 272630003486 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272630003487 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272630003488 active site 272630003489 KMSKS motif; other site 272630003490 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272630003491 tRNA binding surface [nucleotide binding]; other site 272630003492 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 272630003493 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272630003494 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272630003495 G1 box; other site 272630003496 GTP/Mg2+ binding site [chemical binding]; other site 272630003497 Switch I region; other site 272630003498 G2 box; other site 272630003499 Switch II region; other site 272630003500 G3 box; other site 272630003501 G4 box; other site 272630003502 G5 box; other site 272630003503 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272630003504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630003505 PAS fold; Region: PAS_3; pfam08447 272630003506 putative active site [active] 272630003507 heme pocket [chemical binding]; other site 272630003508 PAS fold; Region: PAS_3; pfam08447 272630003509 Helix-turn-helix; Region: HTH_3; pfam01381 272630003510 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272630003511 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272630003512 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 272630003513 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272630003514 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 272630003515 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 272630003516 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272630003517 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272630003518 P-loop; other site 272630003519 Magnesium ion binding site [ion binding]; other site 272630003520 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272630003521 Magnesium ion binding site [ion binding]; other site 272630003522 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272630003523 ParB-like nuclease domain; Region: ParB; smart00470 272630003524 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 272630003525 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 272630003526 Lipopolysaccharide-assembly; Region: LptE; cl01125 272630003527 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 272630003528 B-block binding subunit of TFIIIC; Region: B-block_TFIIIC; pfam04182 272630003529 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 272630003530 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 272630003531 prephenate dehydrogenase; Validated; Region: PRK08507 272630003532 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 272630003533 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272630003534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630003535 homodimer interface [polypeptide binding]; other site 272630003536 catalytic residue [active] 272630003537 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 272630003538 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272630003539 N-terminal plug; other site 272630003540 ligand-binding site [chemical binding]; other site 272630003541 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 272630003542 potassium uptake protein; Region: kup; TIGR00794 272630003543 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 272630003544 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 272630003545 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 272630003546 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 272630003547 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 272630003548 active site 272630003549 nucleophile elbow; other site 272630003550 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272630003551 putative DNA binding site [nucleotide binding]; other site 272630003552 putative Zn2+ binding site [ion binding]; other site 272630003553 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272630003554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630003555 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 272630003556 FAD binding site [chemical binding]; other site 272630003557 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 272630003558 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 272630003559 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 272630003560 substrate binding pocket [chemical binding]; other site 272630003561 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 272630003562 B12 binding site [chemical binding]; other site 272630003563 cobalt ligand [ion binding]; other site 272630003564 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 272630003565 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 272630003566 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 272630003567 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272630003568 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 272630003569 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 272630003570 putative active site [active] 272630003571 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 272630003572 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 272630003573 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 272630003574 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 272630003575 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 272630003576 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 272630003577 ThiC-associated domain; Region: ThiC-associated; pfam13667 272630003578 ThiC family; Region: ThiC; pfam01964 272630003579 FlaG protein; Region: FlaG; cl00591 272630003580 Flagellar protein FlaF; Region: FlaF; cl11454 272630003581 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 272630003582 putative active site [active] 272630003583 putative metal binding site [ion binding]; other site 272630003584 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 272630003585 TolR protein; Region: tolR; TIGR02801 272630003586 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 272630003587 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272630003588 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 272630003589 putative dimer interface [polypeptide binding]; other site 272630003590 Uncharacterized small protein [Function unknown]; Region: COG5568 272630003591 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272630003592 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 272630003593 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 272630003594 putative ADP-binding pocket [chemical binding]; other site 272630003595 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630003596 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 272630003597 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272630003598 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272630003599 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 272630003600 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 272630003601 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630003602 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 272630003603 putative ADP-binding pocket [chemical binding]; other site 272630003604 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 272630003605 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272630003606 23S rRNA binding site [nucleotide binding]; other site 272630003607 L21 binding site [polypeptide binding]; other site 272630003608 L13 binding site [polypeptide binding]; other site 272630003609 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272630003610 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272630003611 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272630003612 dimer interface [polypeptide binding]; other site 272630003613 motif 1; other site 272630003614 active site 272630003615 motif 2; other site 272630003616 motif 3; other site 272630003617 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272630003618 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272630003619 putative tRNA-binding site [nucleotide binding]; other site 272630003620 B3/4 domain; Region: B3_4; pfam03483 272630003621 tRNA synthetase B5 domain; Region: B5; smart00874 272630003622 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 272630003623 dimer interface [polypeptide binding]; other site 272630003624 motif 1; other site 272630003625 motif 3; other site 272630003626 motif 2; other site 272630003627 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 272630003628 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 272630003629 SEC-C motif; Region: SEC-C; pfam02810 272630003630 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 272630003631 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 272630003632 ATP binding site [chemical binding]; other site 272630003633 substrate interface [chemical binding]; other site 272630003634 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 272630003635 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 272630003636 metal binding site [ion binding]; metal-binding site 272630003637 dimer interface [polypeptide binding]; other site 272630003638 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 272630003639 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272630003640 dimerization interface 3.5A [polypeptide binding]; other site 272630003641 active site 272630003642 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272630003643 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272630003644 putative active site [active] 272630003645 substrate binding site [chemical binding]; other site 272630003646 putative cosubstrate binding site; other site 272630003647 catalytic site [active] 272630003648 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272630003649 substrate binding site [chemical binding]; other site 272630003650 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272630003651 active site 272630003652 catalytic residues [active] 272630003653 metal binding site [ion binding]; metal-binding site 272630003654 recombination protein RecR; Reviewed; Region: recR; PRK00076 272630003655 RecR protein; Region: RecR; pfam02132 272630003656 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272630003657 putative active site [active] 272630003658 putative metal-binding site [ion binding]; other site 272630003659 tetramer interface [polypeptide binding]; other site 272630003660 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 272630003661 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 272630003662 active site 272630003663 substrate-binding site [chemical binding]; other site 272630003664 metal-binding site [ion binding] 272630003665 ATP binding site [chemical binding]; other site 272630003666 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 272630003667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630003668 FeS/SAM binding site; other site 272630003669 shikimate kinase; Provisional; Region: PRK13946 272630003670 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 272630003671 ADP binding site [chemical binding]; other site 272630003672 magnesium binding site [ion binding]; other site 272630003673 putative shikimate binding site; other site 272630003674 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 272630003675 active site 272630003676 dimer interface [polypeptide binding]; other site 272630003677 metal binding site [ion binding]; metal-binding site 272630003678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272630003679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272630003680 malate dehydrogenase; Reviewed; Region: PRK06223 272630003681 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 272630003682 NAD(P) binding site [chemical binding]; other site 272630003683 dimer interface [polypeptide binding]; other site 272630003684 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272630003685 substrate binding site [chemical binding]; other site 272630003686 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 272630003687 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 272630003688 CoA-ligase; Region: Ligase_CoA; pfam00549 272630003689 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 272630003690 CoA binding domain; Region: CoA_binding; smart00881 272630003691 CoA-ligase; Region: Ligase_CoA; pfam00549 272630003692 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 272630003693 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 272630003694 TPP-binding site [chemical binding]; other site 272630003695 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 272630003696 dimer interface [polypeptide binding]; other site 272630003697 PYR/PP interface [polypeptide binding]; other site 272630003698 TPP binding site [chemical binding]; other site 272630003699 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 272630003700 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272630003701 E3 interaction surface; other site 272630003702 lipoyl attachment site [posttranslational modification]; other site 272630003703 e3 binding domain; Region: E3_binding; pfam02817 272630003704 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272630003705 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 272630003706 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 272630003707 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272630003708 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272630003709 histidine kinase; Provisional; Region: PRK13557 272630003710 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630003711 putative active site [active] 272630003712 heme pocket [chemical binding]; other site 272630003713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630003714 dimer interface [polypeptide binding]; other site 272630003715 phosphorylation site [posttranslational modification] 272630003716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630003717 ATP binding site [chemical binding]; other site 272630003718 Mg2+ binding site [ion binding]; other site 272630003719 G-X-G motif; other site 272630003720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630003721 active site 272630003722 phosphorylation site [posttranslational modification] 272630003723 intermolecular recognition site; other site 272630003724 dimerization interface [polypeptide binding]; other site 272630003725 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 272630003726 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 272630003727 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 272630003728 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272630003729 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 272630003730 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 272630003731 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272630003732 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 272630003733 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 272630003734 conserved cys residue [active] 272630003735 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 272630003736 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 272630003737 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 272630003738 active site 272630003739 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 272630003740 domain_subunit interface; other site 272630003741 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 272630003742 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 272630003743 active site 272630003744 FMN binding site [chemical binding]; other site 272630003745 substrate binding site [chemical binding]; other site 272630003746 3Fe-4S cluster binding site [ion binding]; other site 272630003747 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 272630003748 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272630003749 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 272630003750 putative active site [active] 272630003751 putative metal binding site [ion binding]; other site 272630003752 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272630003753 HIRAN domain; Region: HIRAN; pfam08797 272630003754 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 272630003755 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 272630003756 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272630003757 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 272630003758 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272630003759 ATP binding site [chemical binding]; other site 272630003760 putative Mg++ binding site [ion binding]; other site 272630003761 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630003762 nucleotide binding region [chemical binding]; other site 272630003763 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 272630003764 AAA ATPase domain; Region: AAA_16; pfam13191 272630003765 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 272630003766 tellurite resistance protein terB; Region: terB; cd07176 272630003767 putative metal binding site [ion binding]; other site 272630003768 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 272630003769 dinuclear metal binding motif [ion binding]; other site 272630003770 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 272630003771 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 272630003772 PAS domain S-box; Region: sensory_box; TIGR00229 272630003773 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630003774 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630003775 metal binding site [ion binding]; metal-binding site 272630003776 active site 272630003777 I-site; other site 272630003778 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630003779 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630003780 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 272630003781 dimer interface [polypeptide binding]; other site 272630003782 putative CheW interface [polypeptide binding]; other site 272630003783 PilZ domain; Region: PilZ; pfam07238 272630003784 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 272630003785 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 272630003786 active site 272630003787 nucleophile elbow; other site 272630003788 Patatin phospholipase; Region: DUF3734; pfam12536 272630003789 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 272630003790 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272630003791 NAD binding site [chemical binding]; other site 272630003792 catalytic Zn binding site [ion binding]; other site 272630003793 structural Zn binding site [ion binding]; other site 272630003794 short chain dehydrogenase; Provisional; Region: PRK07109 272630003795 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 272630003796 putative NAD(P) binding site [chemical binding]; other site 272630003797 active site 272630003798 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 272630003799 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 272630003800 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630003801 PAS domain; Region: PAS_9; pfam13426 272630003802 putative active site [active] 272630003803 heme pocket [chemical binding]; other site 272630003804 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630003805 HWE histidine kinase; Region: HWE_HK; pfam07536 272630003806 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630003807 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630003808 metal binding site [ion binding]; metal-binding site 272630003809 active site 272630003810 I-site; other site 272630003811 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630003812 PAS domain; Region: PAS_9; pfam13426 272630003813 putative active site [active] 272630003814 heme pocket [chemical binding]; other site 272630003815 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630003816 PAS fold; Region: PAS_3; pfam08447 272630003817 putative active site [active] 272630003818 heme pocket [chemical binding]; other site 272630003819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630003820 HWE histidine kinase; Region: HWE_HK; pfam07536 272630003821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630003822 dimer interface [polypeptide binding]; other site 272630003823 phosphorylation site [posttranslational modification] 272630003824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630003825 ATP binding site [chemical binding]; other site 272630003826 Mg2+ binding site [ion binding]; other site 272630003827 G-X-G motif; other site 272630003828 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630003829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630003830 active site 272630003831 phosphorylation site [posttranslational modification] 272630003832 intermolecular recognition site; other site 272630003833 dimerization interface [polypeptide binding]; other site 272630003834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 272630003835 intermolecular recognition site; other site 272630003836 active site 272630003837 dimerization interface [polypeptide binding]; other site 272630003838 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 272630003839 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272630003840 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272630003841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630003842 non-specific DNA binding site [nucleotide binding]; other site 272630003843 salt bridge; other site 272630003844 sequence-specific DNA binding site [nucleotide binding]; other site 272630003845 Domain of unknown function (DUF955); Region: DUF955; cl01076 272630003846 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 272630003847 active site 272630003848 NTP binding site [chemical binding]; other site 272630003849 metal binding triad [ion binding]; metal-binding site 272630003850 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 272630003851 active site 272630003852 nucleophile elbow; other site 272630003853 PLD-like domain; Region: PLDc_2; pfam13091 272630003854 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272630003855 putative active site [active] 272630003856 catalytic site [active] 272630003857 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 272630003858 putative homodimer interface [polypeptide binding]; other site 272630003859 putative active site [active] 272630003860 catalytic site [active] 272630003861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630003862 S-adenosylmethionine binding site [chemical binding]; other site 272630003863 Predicted transcriptional regulator [Transcription]; Region: COG2345 272630003864 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272630003865 Histidine kinase; Region: HisKA_3; pfam07730 272630003866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630003867 ATP binding site [chemical binding]; other site 272630003868 Mg2+ binding site [ion binding]; other site 272630003869 G-X-G motif; other site 272630003870 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272630003871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630003872 active site 272630003873 phosphorylation site [posttranslational modification] 272630003874 intermolecular recognition site; other site 272630003875 dimerization interface [polypeptide binding]; other site 272630003876 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630003877 DNA binding residues [nucleotide binding] 272630003878 dimerization interface [polypeptide binding]; other site 272630003879 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 272630003880 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272630003881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630003882 S-adenosylmethionine binding site [chemical binding]; other site 272630003883 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272630003884 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630003885 dimerization interface [polypeptide binding]; other site 272630003886 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630003887 dimerization interface [polypeptide binding]; other site 272630003888 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630003889 dimerization interface [polypeptide binding]; other site 272630003890 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272630003891 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630003892 dimerization interface [polypeptide binding]; other site 272630003893 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630003894 dimerization interface [polypeptide binding]; other site 272630003895 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630003896 dimerization interface [polypeptide binding]; other site 272630003897 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630003898 dimerization interface [polypeptide binding]; other site 272630003899 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272630003900 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630003901 dimerization interface [polypeptide binding]; other site 272630003902 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630003903 dimerization interface [polypeptide binding]; other site 272630003904 GAF domain; Region: GAF_2; pfam13185 272630003905 GAF domain; Region: GAF_3; pfam13492 272630003906 pinin/SDK/memA/ protein conserved region; Region: Pinin_SDK_memA; pfam04696 272630003907 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630003908 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630003909 dimer interface [polypeptide binding]; other site 272630003910 phosphorylation site [posttranslational modification] 272630003911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630003912 ATP binding site [chemical binding]; other site 272630003913 Mg2+ binding site [ion binding]; other site 272630003914 G-X-G motif; other site 272630003915 Response regulator receiver domain; Region: Response_reg; pfam00072 272630003916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630003917 active site 272630003918 phosphorylation site [posttranslational modification] 272630003919 intermolecular recognition site; other site 272630003920 dimerization interface [polypeptide binding]; other site 272630003921 Response regulator receiver domain; Region: Response_reg; pfam00072 272630003922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630003923 active site 272630003924 phosphorylation site [posttranslational modification] 272630003925 intermolecular recognition site; other site 272630003926 dimerization interface [polypeptide binding]; other site 272630003927 Response regulator receiver domain; Region: Response_reg; pfam00072 272630003928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630003929 active site 272630003930 phosphorylation site [posttranslational modification] 272630003931 intermolecular recognition site; other site 272630003932 dimerization interface [polypeptide binding]; other site 272630003933 Response regulator receiver domain; Region: Response_reg; pfam00072 272630003934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630003935 active site 272630003936 phosphorylation site [posttranslational modification] 272630003937 intermolecular recognition site; other site 272630003938 dimerization interface [polypeptide binding]; other site 272630003939 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272630003940 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630003941 putative active site [active] 272630003942 heme pocket [chemical binding]; other site 272630003943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630003944 dimer interface [polypeptide binding]; other site 272630003945 phosphorylation site [posttranslational modification] 272630003946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630003947 ATP binding site [chemical binding]; other site 272630003948 Mg2+ binding site [ion binding]; other site 272630003949 G-X-G motif; other site 272630003950 Response regulator receiver domain; Region: Response_reg; pfam00072 272630003951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630003952 active site 272630003953 phosphorylation site [posttranslational modification] 272630003954 intermolecular recognition site; other site 272630003955 dimerization interface [polypeptide binding]; other site 272630003956 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 272630003957 NmrA-like family; Region: NmrA; pfam05368 272630003958 NADP binding site [chemical binding]; other site 272630003959 active site 272630003960 regulatory binding site [polypeptide binding]; other site 272630003961 LysR family transcriptional regulator; Provisional; Region: PRK14997 272630003962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630003963 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272630003964 putative effector binding pocket; other site 272630003965 dimerization interface [polypeptide binding]; other site 272630003966 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 272630003967 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 272630003968 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630003969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630003970 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272630003971 dimerization interface [polypeptide binding]; other site 272630003972 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272630003973 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 272630003974 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 272630003975 putative ligand binding site [chemical binding]; other site 272630003976 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 272630003977 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 272630003978 Creatinine amidohydrolase; Region: Creatininase; pfam02633 272630003979 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 272630003980 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272630003981 acyl-activating enzyme (AAE) consensus motif; other site 272630003982 AMP binding site [chemical binding]; other site 272630003983 active site 272630003984 CoA binding site [chemical binding]; other site 272630003985 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 272630003986 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272630003987 FAD binding domain; Region: FAD_binding_4; pfam01565 272630003988 oxidase reductase; Provisional; Region: PTZ00273 272630003989 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 272630003990 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 272630003991 NMT1/THI5 like; Region: NMT1; pfam09084 272630003992 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 272630003993 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 272630003994 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 272630003995 iron-sulfur cluster [ion binding]; other site 272630003996 [2Fe-2S] cluster binding site [ion binding]; other site 272630003997 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 272630003998 hydrophobic ligand binding site; other site 272630003999 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272630004000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630004001 dimer interface [polypeptide binding]; other site 272630004002 conserved gate region; other site 272630004003 putative PBP binding loops; other site 272630004004 ABC-ATPase subunit interface; other site 272630004005 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272630004006 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272630004007 Walker A/P-loop; other site 272630004008 ATP binding site [chemical binding]; other site 272630004009 Q-loop/lid; other site 272630004010 ABC transporter signature motif; other site 272630004011 Walker B; other site 272630004012 D-loop; other site 272630004013 H-loop/switch region; other site 272630004014 NMT1/THI5 like; Region: NMT1; pfam09084 272630004015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630004016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630004017 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272630004018 dimerization interface [polypeptide binding]; other site 272630004019 cytosine deaminase-like protein; Validated; Region: PRK07583 272630004020 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 272630004021 active site 272630004022 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630004023 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630004024 LysR substrate binding domain; Region: LysR_substrate; pfam03466 272630004025 dimerization interface [polypeptide binding]; other site 272630004026 guanine deaminase; Provisional; Region: PRK09228 272630004027 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 272630004028 active site 272630004029 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 272630004030 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272630004031 catalytic loop [active] 272630004032 iron binding site [ion binding]; other site 272630004033 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 272630004034 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 272630004035 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 272630004036 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272630004037 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 272630004038 NMT1/THI5 like; Region: NMT1; pfam09084 272630004039 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272630004040 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 272630004041 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272630004042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272630004043 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272630004044 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272630004045 Walker A/P-loop; other site 272630004046 ATP binding site [chemical binding]; other site 272630004047 Q-loop/lid; other site 272630004048 ABC transporter signature motif; other site 272630004049 Walker B; other site 272630004050 D-loop; other site 272630004051 H-loop/switch region; other site 272630004052 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 272630004053 pyrimidine utilization protein D; Region: RutD; TIGR03611 272630004054 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272630004055 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272630004056 homotrimer interaction site [polypeptide binding]; other site 272630004057 putative active site [active] 272630004058 Isochorismatase family; Region: Isochorismatase; pfam00857 272630004059 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272630004060 catalytic triad [active] 272630004061 conserved cis-peptide bond; other site 272630004062 pyrimidine utilization protein A; Region: RutA; TIGR03612 272630004063 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 272630004064 active site 272630004065 dimer interface [polypeptide binding]; other site 272630004066 non-prolyl cis peptide bond; other site 272630004067 insertion regions; other site 272630004068 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 272630004069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272630004070 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 272630004071 ureidoglycolate hydrolase; Provisional; Region: PRK03606 272630004072 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 272630004073 hypothetical protein; Provisional; Region: PRK11171 272630004074 Cupin domain; Region: Cupin_2; pfam07883 272630004075 Predicted membrane protein [Function unknown]; Region: COG3748 272630004076 Protein of unknown function (DUF989); Region: DUF989; pfam06181 272630004077 Cytochrome c; Region: Cytochrom_C; pfam00034 272630004078 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630004079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630004080 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272630004081 putative effector binding pocket; other site 272630004082 dimerization interface [polypeptide binding]; other site 272630004083 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 272630004084 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 272630004085 active site 272630004086 catalytic site [active] 272630004087 tetramer interface [polypeptide binding]; other site 272630004088 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 272630004089 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 272630004090 active site 272630004091 homotetramer interface [polypeptide binding]; other site 272630004092 Protein of unknown function (DUF808); Region: DUF808; cl01002 272630004093 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630004094 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630004095 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630004096 metal binding site [ion binding]; metal-binding site 272630004097 active site 272630004098 I-site; other site 272630004099 OmpW family; Region: OmpW; cl17427 272630004100 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 272630004101 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 272630004102 Phosphotransferase enzyme family; Region: APH; pfam01636 272630004103 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272630004104 active site 272630004105 substrate binding site [chemical binding]; other site 272630004106 ATP binding site [chemical binding]; other site 272630004107 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 272630004108 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272630004109 putative acyl-acceptor binding pocket; other site 272630004110 topology modulation protein; Reviewed; Region: PRK08118 272630004111 AAA domain; Region: AAA_17; pfam13207 272630004112 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272630004113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630004114 S-adenosylmethionine binding site [chemical binding]; other site 272630004115 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 272630004116 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 272630004117 methionine sulfoxide reductase B; Provisional; Region: PRK00222 272630004118 SelR domain; Region: SelR; pfam01641 272630004119 methionine sulfoxide reductase A; Provisional; Region: PRK13014 272630004120 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 272630004121 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 272630004122 heme binding site [chemical binding]; other site 272630004123 ferroxidase pore; other site 272630004124 ferroxidase diiron center [ion binding]; other site 272630004125 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 272630004126 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272630004127 Ligand Binding Site [chemical binding]; other site 272630004128 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272630004129 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272630004130 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 272630004131 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 272630004132 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 272630004133 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630004134 FeS/SAM binding site; other site 272630004135 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 272630004136 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 272630004137 active site 272630004138 oligomerization interface [polypeptide binding]; other site 272630004139 metal binding site [ion binding]; metal-binding site 272630004140 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272630004141 catalytic residues [active] 272630004142 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272630004143 active site residue [active] 272630004144 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 272630004145 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 272630004146 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272630004147 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272630004148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272630004149 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 272630004150 active site 272630004151 NTP binding site [chemical binding]; other site 272630004152 metal binding triad [ion binding]; metal-binding site 272630004153 antibiotic binding site [chemical binding]; other site 272630004154 Protein of unknown function DUF86; Region: DUF86; cl01031 272630004155 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 272630004156 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 272630004157 P-loop, Walker A motif; other site 272630004158 Base recognition motif; other site 272630004159 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 272630004160 GAF domain; Region: GAF_2; pfam13185 272630004161 GAF domain; Region: GAF; pfam01590 272630004162 PAS domain; Region: PAS_9; pfam13426 272630004163 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 272630004164 PAS domain S-box; Region: sensory_box; TIGR00229 272630004165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630004166 putative active site [active] 272630004167 heme pocket [chemical binding]; other site 272630004168 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630004169 PAS fold; Region: PAS_3; pfam08447 272630004170 putative active site [active] 272630004171 heme pocket [chemical binding]; other site 272630004172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630004173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630004174 dimer interface [polypeptide binding]; other site 272630004175 phosphorylation site [posttranslational modification] 272630004176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630004177 ATP binding site [chemical binding]; other site 272630004178 Mg2+ binding site [ion binding]; other site 272630004179 G-X-G motif; other site 272630004180 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630004181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630004182 active site 272630004183 phosphorylation site [posttranslational modification] 272630004184 intermolecular recognition site; other site 272630004185 dimerization interface [polypeptide binding]; other site 272630004186 YcjX-like family, DUF463; Region: DUF463; pfam04317 272630004187 Domain of unknown function (DUF697); Region: DUF697; cl12064 272630004188 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 272630004189 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272630004190 diaminopimelate decarboxylase; Region: lysA; TIGR01048 272630004191 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 272630004192 active site 272630004193 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272630004194 substrate binding site [chemical binding]; other site 272630004195 catalytic residues [active] 272630004196 dimer interface [polypeptide binding]; other site 272630004197 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 272630004198 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 272630004199 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272630004200 RNA/DNA hybrid binding site [nucleotide binding]; other site 272630004201 active site 272630004202 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 272630004203 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272630004204 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 272630004205 putative active site [active] 272630004206 putative metal binding site [ion binding]; other site 272630004207 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 272630004208 homodimer interface [polypeptide binding]; other site 272630004209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630004210 catalytic residue [active] 272630004211 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 272630004212 glycerate dehydrogenase; Provisional; Region: PRK06487 272630004213 putative ligand binding site [chemical binding]; other site 272630004214 putative NAD binding site [chemical binding]; other site 272630004215 catalytic site [active] 272630004216 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 272630004217 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 272630004218 NADP binding site [chemical binding]; other site 272630004219 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 272630004220 malate--CoA ligase subunit beta; Provisional; Region: PRK14046 272630004221 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 272630004222 CoA-ligase; Region: Ligase_CoA; pfam00549 272630004223 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 272630004224 CoA binding domain; Region: CoA_binding; pfam02629 272630004225 CoA-ligase; Region: Ligase_CoA; pfam00549 272630004226 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 272630004227 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 272630004228 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 272630004229 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 272630004230 Dienelactone hydrolase family; Region: DLH; pfam01738 272630004231 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272630004232 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 272630004233 aromatic arch; other site 272630004234 DCoH dimer interaction site [polypeptide binding]; other site 272630004235 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 272630004236 DCoH tetramer interaction site [polypeptide binding]; other site 272630004237 substrate binding site [chemical binding]; other site 272630004238 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272630004239 substrate binding pocket [chemical binding]; other site 272630004240 membrane-bound complex binding site; other site 272630004241 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272630004242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630004243 dimer interface [polypeptide binding]; other site 272630004244 conserved gate region; other site 272630004245 putative PBP binding loops; other site 272630004246 ABC-ATPase subunit interface; other site 272630004247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630004248 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272630004249 Walker A/P-loop; other site 272630004250 ATP binding site [chemical binding]; other site 272630004251 Q-loop/lid; other site 272630004252 ABC transporter signature motif; other site 272630004253 Walker B; other site 272630004254 D-loop; other site 272630004255 H-loop/switch region; other site 272630004256 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 272630004257 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 272630004258 Trp docking motif [polypeptide binding]; other site 272630004259 dimer interface [polypeptide binding]; other site 272630004260 active site 272630004261 small subunit binding site [polypeptide binding]; other site 272630004262 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 272630004263 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 272630004264 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272630004265 substrate binding pocket [chemical binding]; other site 272630004266 membrane-bound complex binding site; other site 272630004267 hinge residues; other site 272630004268 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 272630004269 catalytic center binding site [active] 272630004270 ATP binding site [chemical binding]; other site 272630004271 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 272630004272 homooctamer interface [polypeptide binding]; other site 272630004273 active site 272630004274 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 272630004275 dihydropteroate synthase; Region: DHPS; TIGR01496 272630004276 substrate binding pocket [chemical binding]; other site 272630004277 dimer interface [polypeptide binding]; other site 272630004278 inhibitor binding site; inhibition site 272630004279 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 272630004280 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630004281 FeS/SAM binding site; other site 272630004282 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 272630004283 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 272630004284 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 272630004285 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 272630004286 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 272630004287 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272630004288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630004289 active site 272630004290 phosphorylation site [posttranslational modification] 272630004291 intermolecular recognition site; other site 272630004292 dimerization interface [polypeptide binding]; other site 272630004293 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630004294 DNA binding site [nucleotide binding] 272630004295 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630004296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630004297 dimer interface [polypeptide binding]; other site 272630004298 phosphorylation site [posttranslational modification] 272630004299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630004300 ATP binding site [chemical binding]; other site 272630004301 Mg2+ binding site [ion binding]; other site 272630004302 G-X-G motif; other site 272630004303 FwdC/FmdC. This domain of unknown function is found in the subunit C of formylmethanofuran dehydrogenase, an enzyme that catalyzes the first step in methane formation from CO2 in methanogenic archaea, hyperthermophiles and bacteria. There are two...; Region: FwdC/FmdC; cd00980 272630004304 putative subunit interface; other site 272630004305 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 272630004306 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 272630004307 FTR, proximal lobe; Region: FTR_C; pfam02741 272630004308 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 272630004309 Formylmethanofuran dehydrogenase (FMDH) subunit A; Methanogenic bacteria and archea derive the energy for autotrophic growth from methanogenesis, the reduction of CO2 with molecular hydrogen as the electron donor. FMDH catalyzes the first step in...; Region: FMDH_A; cd01304 272630004310 active site 272630004311 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272630004312 molybdopterin cofactor binding site; other site 272630004313 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 272630004314 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 272630004315 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 272630004316 NADP binding site [chemical binding]; other site 272630004317 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272630004318 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 272630004319 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 272630004320 trimer interface I [polypeptide binding]; other site 272630004321 putative substrate binding pocket [chemical binding]; other site 272630004322 trimer interface II [polypeptide binding]; other site 272630004323 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 272630004324 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272630004325 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 272630004326 formaldehyde-activating enzyme; Region: one_C_fae; TIGR03126 272630004327 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 272630004328 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 272630004329 active site 272630004330 probable H4MPT-linked C1 transfer pathway protein; Region: one_C_unchar_1; TIGR03123 272630004331 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 272630004332 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272630004333 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272630004334 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272630004335 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272630004336 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 272630004337 putative hydrophobic ligand binding site [chemical binding]; other site 272630004338 protein interface [polypeptide binding]; other site 272630004339 gate; other site 272630004340 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 272630004341 putative hydrophobic ligand binding site [chemical binding]; other site 272630004342 protein interface [polypeptide binding]; other site 272630004343 gate; other site 272630004344 Protein of unknown function (DUF447); Region: DUF447; pfam04289 272630004345 dihydropteroate synthase-related protein; Region: TIGR00284 272630004346 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 272630004347 substrate binding pocket [chemical binding]; other site 272630004348 dimer interface [polypeptide binding]; other site 272630004349 inhibitor binding site; inhibition site 272630004350 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 272630004351 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 272630004352 nucleotide binding site [chemical binding]; other site 272630004353 substrate binding site [chemical binding]; other site 272630004354 hypothetical protein; Provisional; Region: PRK02227 272630004355 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 272630004356 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 272630004357 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 272630004358 ligand binding site [chemical binding]; other site 272630004359 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 272630004360 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272630004361 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272630004362 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272630004363 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272630004364 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 272630004365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630004366 Walker A/P-loop; other site 272630004367 ATP binding site [chemical binding]; other site 272630004368 Q-loop/lid; other site 272630004369 ABC transporter signature motif; other site 272630004370 Walker B; other site 272630004371 D-loop; other site 272630004372 H-loop/switch region; other site 272630004373 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272630004374 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272630004375 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272630004376 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272630004377 EF-hand domain pair; Region: EF_hand_5; pfam13499 272630004378 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 272630004379 Ca2+ binding site [ion binding]; other site 272630004380 hypothetical protein; Validated; Region: PRK00068 272630004381 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 272630004382 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 272630004383 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630004384 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272630004385 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 272630004386 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 272630004387 SLBB domain; Region: SLBB; pfam10531 272630004388 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 272630004389 Chain length determinant protein; Region: Wzz; pfam02706 272630004390 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 272630004391 hypothetical protein; Validated; Region: PRK00153 272630004392 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 272630004393 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 272630004394 active site 272630004395 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272630004396 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 272630004397 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 272630004398 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 272630004399 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 272630004400 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272630004401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630004402 Walker A motif; other site 272630004403 ATP binding site [chemical binding]; other site 272630004404 Walker B motif; other site 272630004405 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 272630004406 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272630004407 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 272630004408 putative C-terminal domain interface [polypeptide binding]; other site 272630004409 putative GSH binding site (G-site) [chemical binding]; other site 272630004410 putative dimer interface [polypeptide binding]; other site 272630004411 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 272630004412 N-terminal domain interface [polypeptide binding]; other site 272630004413 dimer interface [polypeptide binding]; other site 272630004414 substrate binding pocket (H-site) [chemical binding]; other site 272630004415 Uncharacterized conserved protein [Function unknown]; Region: COG3287 272630004416 FIST N domain; Region: FIST; pfam08495 272630004417 FIST C domain; Region: FIST_C; pfam10442 272630004418 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630004419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630004420 dimer interface [polypeptide binding]; other site 272630004421 phosphorylation site [posttranslational modification] 272630004422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630004423 ATP binding site [chemical binding]; other site 272630004424 Mg2+ binding site [ion binding]; other site 272630004425 G-X-G motif; other site 272630004426 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630004427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630004428 active site 272630004429 phosphorylation site [posttranslational modification] 272630004430 intermolecular recognition site; other site 272630004431 dimerization interface [polypeptide binding]; other site 272630004432 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 272630004433 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 272630004434 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 272630004435 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 272630004436 substrate binding pocket [chemical binding]; other site 272630004437 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272630004438 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272630004439 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272630004440 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272630004441 catalytic residue [active] 272630004442 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 272630004443 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 272630004444 putative [4Fe-4S] binding site [ion binding]; other site 272630004445 putative molybdopterin cofactor binding site [chemical binding]; other site 272630004446 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 272630004447 putative molybdopterin cofactor binding site; other site 272630004448 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 272630004449 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272630004450 Walker A/P-loop; other site 272630004451 ATP binding site [chemical binding]; other site 272630004452 Q-loop/lid; other site 272630004453 ABC transporter signature motif; other site 272630004454 Walker B; other site 272630004455 D-loop; other site 272630004456 H-loop/switch region; other site 272630004457 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272630004458 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272630004459 Walker A/P-loop; other site 272630004460 ATP binding site [chemical binding]; other site 272630004461 Q-loop/lid; other site 272630004462 ABC transporter signature motif; other site 272630004463 Walker B; other site 272630004464 D-loop; other site 272630004465 H-loop/switch region; other site 272630004466 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272630004467 phosphopentomutase; Provisional; Region: PRK05362 272630004468 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 272630004469 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 272630004470 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630004471 Walker A/P-loop; other site 272630004472 ATP binding site [chemical binding]; other site 272630004473 Q-loop/lid; other site 272630004474 ABC transporter signature motif; other site 272630004475 Walker B; other site 272630004476 D-loop; other site 272630004477 H-loop/switch region; other site 272630004478 ABC transporter; Region: ABC_tran_2; pfam12848 272630004479 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272630004480 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 272630004481 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 272630004482 active site 272630004483 substrate binding site [chemical binding]; other site 272630004484 Mg2+ binding site [ion binding]; other site 272630004485 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 272630004486 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272630004487 TPP-binding site; other site 272630004488 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272630004489 PYR/PP interface [polypeptide binding]; other site 272630004490 dimer interface [polypeptide binding]; other site 272630004491 TPP binding site [chemical binding]; other site 272630004492 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272630004493 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 272630004494 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 272630004495 putative NADP binding site [chemical binding]; other site 272630004496 putative substrate binding site [chemical binding]; other site 272630004497 active site 272630004498 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 272630004499 active site lid residues [active] 272630004500 substrate binding pocket [chemical binding]; other site 272630004501 catalytic residues [active] 272630004502 substrate-Mg2+ binding site; other site 272630004503 aspartate-rich region 1; other site 272630004504 aspartate-rich region 2; other site 272630004505 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 272630004506 active site lid residues [active] 272630004507 substrate binding pocket [chemical binding]; other site 272630004508 catalytic residues [active] 272630004509 substrate-Mg2+ binding site; other site 272630004510 aspartate-rich region 1; other site 272630004511 aspartate-rich region 2; other site 272630004512 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 272630004513 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 272630004514 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 272630004515 Active site cavity [active] 272630004516 catalytic acid [active] 272630004517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272630004518 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 272630004519 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 272630004520 substrate-cofactor binding pocket; other site 272630004521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630004522 catalytic residue [active] 272630004523 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272630004524 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 272630004525 active site 272630004526 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 272630004527 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 272630004528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630004529 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 272630004530 Enoylreductase; Region: PKS_ER; smart00829 272630004531 NAD(P) binding site [chemical binding]; other site 272630004532 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 272630004533 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 272630004534 putative NADP binding site [chemical binding]; other site 272630004535 active site 272630004536 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272630004537 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 272630004538 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272630004539 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 272630004540 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 272630004541 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 272630004542 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272630004543 Probable Catalytic site; other site 272630004544 metal-binding site 272630004545 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272630004546 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272630004547 Probable Catalytic site; other site 272630004548 metal-binding site 272630004549 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272630004550 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 272630004551 Protein of unknown function, DUF462; Region: DUF462; cl01190 272630004552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630004553 active site 272630004554 phosphorylation site [posttranslational modification] 272630004555 intermolecular recognition site; other site 272630004556 response regulator FixJ; Provisional; Region: fixJ; PRK09390 272630004557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630004558 active site 272630004559 phosphorylation site [posttranslational modification] 272630004560 intermolecular recognition site; other site 272630004561 dimerization interface [polypeptide binding]; other site 272630004562 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630004563 DNA binding residues [nucleotide binding] 272630004564 dimerization interface [polypeptide binding]; other site 272630004565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630004566 PAS domain; Region: PAS_9; pfam13426 272630004567 putative active site [active] 272630004568 heme pocket [chemical binding]; other site 272630004569 PAS domain S-box; Region: sensory_box; TIGR00229 272630004570 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630004571 putative active site [active] 272630004572 heme pocket [chemical binding]; other site 272630004573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630004574 dimer interface [polypeptide binding]; other site 272630004575 phosphorylation site [posttranslational modification] 272630004576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630004577 ATP binding site [chemical binding]; other site 272630004578 Mg2+ binding site [ion binding]; other site 272630004579 G-X-G motif; other site 272630004580 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 272630004581 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630004582 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272630004583 DNA binding residues [nucleotide binding] 272630004584 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 272630004585 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 272630004586 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 272630004587 FAD binding pocket [chemical binding]; other site 272630004588 FAD binding motif [chemical binding]; other site 272630004589 phosphate binding motif [ion binding]; other site 272630004590 beta-alpha-beta structure motif; other site 272630004591 NAD binding pocket [chemical binding]; other site 272630004592 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272630004593 catalytic loop [active] 272630004594 iron binding site [ion binding]; other site 272630004595 Predicted transcriptional regulator [Transcription]; Region: COG4957 272630004596 LTXXQ motif family protein; Region: LTXXQ; pfam07813 272630004597 glycogen branching enzyme; Provisional; Region: PRK05402 272630004598 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 272630004599 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 272630004600 active site 272630004601 catalytic site [active] 272630004602 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 272630004603 glycogen synthase; Provisional; Region: glgA; PRK00654 272630004604 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 272630004605 ADP-binding pocket [chemical binding]; other site 272630004606 homodimer interface [polypeptide binding]; other site 272630004607 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 272630004608 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 272630004609 Multicopper oxidase; Region: Cu-oxidase; pfam00394 272630004610 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 272630004611 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 272630004612 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 272630004613 Domain of unknown function (DUF305); Region: DUF305; cl17794 272630004614 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 272630004615 Domain interface; other site 272630004616 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 272630004617 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 272630004618 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 272630004619 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272630004620 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272630004621 TPP-binding site [chemical binding]; other site 272630004622 dimer interface [polypeptide binding]; other site 272630004623 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272630004624 PYR/PP interface [polypeptide binding]; other site 272630004625 dimer interface [polypeptide binding]; other site 272630004626 TPP binding site [chemical binding]; other site 272630004627 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272630004628 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 272630004629 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 272630004630 putative active site [active] 272630004631 catalytic residue [active] 272630004632 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272630004633 active site 272630004634 dimer interface [polypeptide binding]; other site 272630004635 SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798 272630004636 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272630004637 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 272630004638 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 272630004639 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 272630004640 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 272630004641 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272630004642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272630004643 active site 272630004644 motif I; other site 272630004645 motif II; other site 272630004646 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272630004647 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 272630004648 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 272630004649 putative active site [active] 272630004650 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 272630004651 ATP-binding site [chemical binding]; other site 272630004652 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272630004653 active site 272630004654 motif I; other site 272630004655 motif II; other site 272630004656 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 272630004657 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272630004658 AAA-like domain; Region: AAA_10; pfam12846 272630004659 Walker A motif; other site 272630004660 ATP binding site [chemical binding]; other site 272630004661 Walker B motif; other site 272630004662 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 272630004663 YHS domain; Region: YHS; pfam04945 272630004664 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272630004665 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272630004666 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272630004667 motif II; other site 272630004668 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 272630004669 Acetokinase family; Region: Acetate_kinase; cl17229 272630004670 propionate/acetate kinase; Provisional; Region: PRK12379 272630004671 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 272630004672 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272630004673 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 272630004674 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cl07672 272630004675 Domain interface; other site 272630004676 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 272630004677 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 272630004678 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 272630004679 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272630004680 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272630004681 P-loop; other site 272630004682 Magnesium ion binding site [ion binding]; other site 272630004683 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 272630004684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630004685 non-specific DNA binding site [nucleotide binding]; other site 272630004686 salt bridge; other site 272630004687 sequence-specific DNA binding site [nucleotide binding]; other site 272630004688 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272630004689 active site 272630004690 catalytic residues [active] 272630004691 DNA binding site [nucleotide binding] 272630004692 Int/Topo IB signature motif; other site 272630004693 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 272630004694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630004695 putative substrate translocation pore; other site 272630004696 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 272630004697 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 272630004698 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 272630004699 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 272630004700 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272630004701 Sel1-like repeats; Region: SEL1; smart00671 272630004702 Sel1-like repeats; Region: SEL1; smart00671 272630004703 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 272630004704 putative catalytic site [active] 272630004705 putative phosphate binding site [ion binding]; other site 272630004706 active site 272630004707 metal binding site A [ion binding]; metal-binding site 272630004708 DNA binding site [nucleotide binding] 272630004709 putative AP binding site [nucleotide binding]; other site 272630004710 putative metal binding site B [ion binding]; other site 272630004711 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 272630004712 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272630004713 acyl-activating enzyme (AAE) consensus motif; other site 272630004714 AMP binding site [chemical binding]; other site 272630004715 active site 272630004716 CoA binding site [chemical binding]; other site 272630004717 Uncharacterized small protein [Function unknown]; Region: COG5570 272630004718 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 272630004719 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 272630004720 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 272630004721 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 272630004722 ATP-grasp domain; Region: ATP-grasp; pfam02222 272630004723 TPR repeat; Region: TPR_11; pfam13414 272630004724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272630004725 binding surface 272630004726 TPR motif; other site 272630004727 TPR repeat; Region: TPR_11; pfam13414 272630004728 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272630004729 binding surface 272630004730 TPR motif; other site 272630004731 TPR repeat; Region: TPR_11; pfam13414 272630004732 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 272630004733 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 272630004734 putative active site [active] 272630004735 homoserine dehydrogenase; Provisional; Region: PRK06349 272630004736 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 272630004737 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 272630004738 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 272630004739 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 272630004740 Nucleoside recognition; Region: Gate; pfam07670 272630004741 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 272630004742 Predicted methyltransferase [General function prediction only]; Region: COG3897 272630004743 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 272630004744 putative ADP-binding pocket [chemical binding]; other site 272630004745 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630004746 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 272630004747 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 272630004748 active site 272630004749 DNA binding site [nucleotide binding] 272630004750 Int/Topo IB signature motif; other site 272630004751 catalytic residues [active] 272630004752 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630004753 dimer interface [polypeptide binding]; other site 272630004754 putative CheW interface [polypeptide binding]; other site 272630004755 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 272630004756 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272630004757 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630004758 DNA binding residues [nucleotide binding] 272630004759 dimerization interface [polypeptide binding]; other site 272630004760 Response regulator receiver domain; Region: Response_reg; pfam00072 272630004761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630004762 active site 272630004763 phosphorylation site [posttranslational modification] 272630004764 intermolecular recognition site; other site 272630004765 dimerization interface [polypeptide binding]; other site 272630004766 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630004767 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630004768 metal binding site [ion binding]; metal-binding site 272630004769 active site 272630004770 I-site; other site 272630004771 Iron permease FTR1 family; Region: FTR1; cl00475 272630004772 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 272630004773 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272630004774 active site 272630004775 hypothetical protein; Provisional; Region: PRK02853 272630004776 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 272630004777 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 272630004778 NAD binding site [chemical binding]; other site 272630004779 dimerization interface [polypeptide binding]; other site 272630004780 product binding site; other site 272630004781 substrate binding site [chemical binding]; other site 272630004782 zinc binding site [ion binding]; other site 272630004783 catalytic residues [active] 272630004784 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 272630004785 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 272630004786 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272630004787 hinge; other site 272630004788 active site 272630004789 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 272630004790 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 272630004791 substrate-cofactor binding pocket; other site 272630004792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630004793 catalytic residue [active] 272630004794 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 272630004795 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 272630004796 PhnA protein; Region: PhnA; pfam03831 272630004797 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 272630004798 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 272630004799 hypothetical protein; Provisional; Region: PRK11820 272630004800 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 272630004801 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 272630004802 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 272630004803 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272630004804 catalytic site [active] 272630004805 G-X2-G-X-G-K; other site 272630004806 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272630004807 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272630004808 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 272630004809 Walker A/P-loop; other site 272630004810 ATP binding site [chemical binding]; other site 272630004811 Q-loop/lid; other site 272630004812 ABC transporter signature motif; other site 272630004813 Walker B; other site 272630004814 D-loop; other site 272630004815 H-loop/switch region; other site 272630004816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272630004817 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630004818 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 272630004819 putative FMN binding site [chemical binding]; other site 272630004820 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 272630004821 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 272630004822 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272630004823 N-terminal plug; other site 272630004824 ligand-binding site [chemical binding]; other site 272630004825 Entner-Doudoroff aldolase; Region: eda; TIGR01182 272630004826 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 272630004827 active site 272630004828 intersubunit interface [polypeptide binding]; other site 272630004829 catalytic residue [active] 272630004830 phosphogluconate dehydratase; Validated; Region: PRK09054 272630004831 6-phosphogluconate dehydratase; Region: edd; TIGR01196 272630004832 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 272630004833 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 272630004834 dimerization interface [polypeptide binding]; other site 272630004835 domain crossover interface; other site 272630004836 redox-dependent activation switch; other site 272630004837 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 272630004838 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272630004839 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 272630004840 Peptidase family M48; Region: Peptidase_M48; cl12018 272630004841 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 272630004842 Protein of unknown function (DUF466); Region: DUF466; pfam04328 272630004843 carbon starvation protein A; Provisional; Region: PRK15015 272630004844 Carbon starvation protein CstA; Region: CstA; pfam02554 272630004845 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 272630004846 Repair protein; Region: Repair_PSII; cl01535 272630004847 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 272630004848 Repair protein; Region: Repair_PSII; pfam04536 272630004849 LemA family; Region: LemA; pfam04011 272630004850 Rdx family; Region: Rdx; cl01407 272630004851 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630004852 PAS domain; Region: PAS_9; pfam13426 272630004853 putative active site [active] 272630004854 heme pocket [chemical binding]; other site 272630004855 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630004856 HWE histidine kinase; Region: HWE_HK; pfam07536 272630004857 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272630004858 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272630004859 active site 272630004860 catalytic tetrad [active] 272630004861 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272630004862 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272630004863 ligand binding site [chemical binding]; other site 272630004864 flexible hinge region; other site 272630004865 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272630004866 putative switch regulator; other site 272630004867 non-specific DNA interactions [nucleotide binding]; other site 272630004868 DNA binding site [nucleotide binding] 272630004869 sequence specific DNA binding site [nucleotide binding]; other site 272630004870 putative cAMP binding site [chemical binding]; other site 272630004871 glycogen synthase; Provisional; Region: glgA; PRK00654 272630004872 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 272630004873 ADP-binding pocket [chemical binding]; other site 272630004874 homodimer interface [polypeptide binding]; other site 272630004875 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 272630004876 homodimer interface [polypeptide binding]; other site 272630004877 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 272630004878 active site pocket [active] 272630004879 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 272630004880 FAD binding pocket [chemical binding]; other site 272630004881 FAD binding motif [chemical binding]; other site 272630004882 phosphate binding motif [ion binding]; other site 272630004883 beta-alpha-beta structure motif; other site 272630004884 NAD binding pocket [chemical binding]; other site 272630004885 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 272630004886 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630004887 PAS fold; Region: PAS_3; pfam08447 272630004888 putative active site [active] 272630004889 heme pocket [chemical binding]; other site 272630004890 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630004891 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630004892 metal binding site [ion binding]; metal-binding site 272630004893 active site 272630004894 I-site; other site 272630004895 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630004896 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 272630004897 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 272630004898 Mg++ binding site [ion binding]; other site 272630004899 putative catalytic motif [active] 272630004900 putative substrate binding site [chemical binding]; other site 272630004901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630004902 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 272630004903 NAD(P) binding site [chemical binding]; other site 272630004904 active site 272630004905 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 272630004906 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272630004907 Predicted transcriptional regulators [Transcription]; Region: COG1733 272630004908 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272630004909 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 272630004910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630004911 NAD(P) binding site [chemical binding]; other site 272630004912 active site 272630004913 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 272630004914 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272630004915 putative active site [active] 272630004916 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272630004917 putative active site [active] 272630004918 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 272630004919 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 272630004920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272630004921 Coenzyme A binding pocket [chemical binding]; other site 272630004922 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 272630004923 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 272630004924 dimer interface [polypeptide binding]; other site 272630004925 active site 272630004926 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272630004927 catalytic residues [active] 272630004928 substrate binding site [chemical binding]; other site 272630004929 speF element; MexAM1_META1pmiscRNA2 272630004930 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 272630004931 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 272630004932 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272630004933 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272630004934 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 272630004935 FMN binding site [chemical binding]; other site 272630004936 active site 272630004937 substrate binding site [chemical binding]; other site 272630004938 catalytic residue [active] 272630004939 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272630004940 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272630004941 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 272630004942 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 272630004943 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 272630004944 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 272630004945 putative phosphate acyltransferase; Provisional; Region: PRK05331 272630004946 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 272630004947 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272630004948 dimer interface [polypeptide binding]; other site 272630004949 active site 272630004950 CoA binding pocket [chemical binding]; other site 272630004951 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272630004952 IHF dimer interface [polypeptide binding]; other site 272630004953 IHF - DNA interface [nucleotide binding]; other site 272630004954 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 272630004955 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 272630004956 DNA binding residues [nucleotide binding] 272630004957 PrkA family serine protein kinase; Provisional; Region: PRK15455 272630004958 AAA ATPase domain; Region: AAA_16; pfam13191 272630004959 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 272630004960 hypothetical protein; Provisional; Region: PRK05325 272630004961 SpoVR family protein; Provisional; Region: PRK11767 272630004962 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 272630004963 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 272630004964 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 272630004965 active site 272630004966 substrate binding site [chemical binding]; other site 272630004967 cosubstrate binding site; other site 272630004968 catalytic site [active] 272630004969 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 272630004970 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 272630004971 dimerization interface [polypeptide binding]; other site 272630004972 putative ATP binding site [chemical binding]; other site 272630004973 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272630004974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272630004975 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 272630004976 polyphosphate kinase; Provisional; Region: PRK05443 272630004977 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 272630004978 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 272630004979 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 272630004980 putative domain interface [polypeptide binding]; other site 272630004981 putative active site [active] 272630004982 catalytic site [active] 272630004983 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 272630004984 putative domain interface [polypeptide binding]; other site 272630004985 putative active site [active] 272630004986 catalytic site [active] 272630004987 exopolyphosphatase; Region: exo_poly_only; TIGR03706 272630004988 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 272630004989 aspartate aminotransferase; Provisional; Region: PRK05764 272630004990 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272630004991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630004992 homodimer interface [polypeptide binding]; other site 272630004993 catalytic residue [active] 272630004994 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 272630004995 Coenzyme A transferase; Region: CoA_trans; smart00882 272630004996 Coenzyme A transferase; Region: CoA_trans; cl17247 272630004997 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 272630004998 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272630004999 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630005000 dimerization interface [polypeptide binding]; other site 272630005001 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630005002 dimer interface [polypeptide binding]; other site 272630005003 putative CheW interface [polypeptide binding]; other site 272630005004 30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311 272630005005 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272630005006 rRNA interaction site [nucleotide binding]; other site 272630005007 S8 interaction site; other site 272630005008 putative laminin-1 binding site; other site 272630005009 Uncharacterized conserved protein [Function unknown]; Region: COG3743 272630005010 elongation factor Ts; Provisional; Region: tsf; PRK09377 272630005011 UBA/TS-N domain; Region: UBA; pfam00627 272630005012 Elongation factor TS; Region: EF_TS; pfam00889 272630005013 Elongation factor TS; Region: EF_TS; pfam00889 272630005014 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272630005015 putative nucleotide binding site [chemical binding]; other site 272630005016 uridine monophosphate binding site [chemical binding]; other site 272630005017 homohexameric interface [polypeptide binding]; other site 272630005018 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 272630005019 dimer interface [polypeptide binding]; other site 272630005020 substrate binding site [chemical binding]; other site 272630005021 metal binding sites [ion binding]; metal-binding site 272630005022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272630005023 Coenzyme A binding pocket [chemical binding]; other site 272630005024 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 272630005025 Putative phosphatase (DUF442); Region: DUF442; cl17385 272630005026 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 272630005027 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 272630005028 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 272630005029 trimer interface [polypeptide binding]; other site 272630005030 active site 272630005031 UDP-GlcNAc binding site [chemical binding]; other site 272630005032 lipid binding site [chemical binding]; lipid-binding site 272630005033 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 272630005034 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272630005035 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272630005036 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272630005037 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272630005038 Surface antigen; Region: Bac_surface_Ag; pfam01103 272630005039 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272630005040 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 272630005041 active site 272630005042 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272630005043 protein binding site [polypeptide binding]; other site 272630005044 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 272630005045 putative substrate binding region [chemical binding]; other site 272630005046 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 272630005047 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 272630005048 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 272630005049 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 272630005050 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 272630005051 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 272630005052 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 272630005053 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 272630005054 catalytic residue [active] 272630005055 putative FPP diphosphate binding site; other site 272630005056 putative FPP binding hydrophobic cleft; other site 272630005057 dimer interface [polypeptide binding]; other site 272630005058 putative IPP diphosphate binding site; other site 272630005059 ribosome recycling factor; Reviewed; Region: frr; PRK00083 272630005060 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272630005061 hinge region; other site 272630005062 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 272630005063 HPP family; Region: HPP; pfam04982 272630005064 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 272630005065 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 272630005066 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272630005067 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 272630005068 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630005069 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 272630005070 dimerization interface [polypeptide binding]; other site 272630005071 substrate binding pocket [chemical binding]; other site 272630005072 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272630005073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630005074 NAD(P) binding site [chemical binding]; other site 272630005075 active site 272630005076 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272630005077 TPP-binding site [chemical binding]; other site 272630005078 dimer interface [polypeptide binding]; other site 272630005079 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 272630005080 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272630005081 PYR/PP interface [polypeptide binding]; other site 272630005082 dimer interface [polypeptide binding]; other site 272630005083 TPP binding site [chemical binding]; other site 272630005084 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272630005085 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 272630005086 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 272630005087 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 272630005088 DctM-like transporters; Region: DctM; pfam06808 272630005089 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 272630005090 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 272630005091 Calx-beta domain; Region: Calx-beta; cl02522 272630005092 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 272630005093 generic binding surface II; other site 272630005094 generic binding surface I; other site 272630005095 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 272630005096 putative active site [active] 272630005097 putative catalytic site [active] 272630005098 putative Mg binding site IVb [ion binding]; other site 272630005099 putative phosphate binding site [ion binding]; other site 272630005100 putative DNA binding site [nucleotide binding]; other site 272630005101 putative Mg binding site IVa [ion binding]; other site 272630005102 Bacterial Ig-like domain; Region: Big_5; pfam13205 272630005103 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272630005104 active site 272630005105 metal binding site [ion binding]; metal-binding site 272630005106 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272630005107 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 272630005108 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 272630005109 active site 272630005110 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 272630005111 catalytic triad [active] 272630005112 dimer interface [polypeptide binding]; other site 272630005113 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 272630005114 Nitrogen regulatory protein P-II; Region: P-II; smart00938 272630005115 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 272630005116 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 272630005117 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 272630005118 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 272630005119 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272630005120 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 272630005121 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272630005122 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272630005123 PAS fold; Region: PAS_4; pfam08448 272630005124 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630005125 PAS fold; Region: PAS_3; pfam08447 272630005126 putative active site [active] 272630005127 heme pocket [chemical binding]; other site 272630005128 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630005129 HWE histidine kinase; Region: HWE_HK; smart00911 272630005130 Probable phenylalanyl-tRNA synthetase alpha chain; Region: PLN02853 272630005131 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 272630005132 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 272630005133 putative molybdopterin cofactor binding site [chemical binding]; other site 272630005134 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 272630005135 putative molybdopterin cofactor binding site; other site 272630005136 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 272630005137 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 272630005138 quinone interaction residues [chemical binding]; other site 272630005139 active site 272630005140 catalytic residues [active] 272630005141 FMN binding site [chemical binding]; other site 272630005142 substrate binding site [chemical binding]; other site 272630005143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 272630005144 Predicted transcriptional regulator [Transcription]; Region: COG2932 272630005145 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272630005146 Catalytic site [active] 272630005147 serine acetyltransferase; Provisional; Region: cysE; PRK11132 272630005148 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 272630005149 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 272630005150 trimer interface [polypeptide binding]; other site 272630005151 active site 272630005152 substrate binding site [chemical binding]; other site 272630005153 CoA binding site [chemical binding]; other site 272630005154 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 272630005155 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630005156 non-specific DNA binding site [nucleotide binding]; other site 272630005157 salt bridge; other site 272630005158 sequence-specific DNA binding site [nucleotide binding]; other site 272630005159 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 272630005160 ADP binding site [chemical binding]; other site 272630005161 magnesium binding site [ion binding]; other site 272630005162 putative shikimate binding site; other site 272630005163 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 272630005164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630005165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 272630005166 dimer interface [polypeptide binding]; other site 272630005167 phosphorylation site [posttranslational modification] 272630005168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630005169 ATP binding site [chemical binding]; other site 272630005170 Mg2+ binding site [ion binding]; other site 272630005171 G-X-G motif; other site 272630005172 osmolarity response regulator; Provisional; Region: ompR; PRK09468 272630005173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630005174 active site 272630005175 phosphorylation site [posttranslational modification] 272630005176 intermolecular recognition site; other site 272630005177 dimerization interface [polypeptide binding]; other site 272630005178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630005179 DNA binding site [nucleotide binding] 272630005180 Response regulator receiver domain; Region: Response_reg; pfam00072 272630005181 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 272630005182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630005183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630005184 dimer interface [polypeptide binding]; other site 272630005185 phosphorylation site [posttranslational modification] 272630005186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630005187 ATP binding site [chemical binding]; other site 272630005188 Mg2+ binding site [ion binding]; other site 272630005189 G-X-G motif; other site 272630005190 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272630005191 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272630005192 active site 272630005193 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272630005194 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272630005195 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 272630005196 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 272630005197 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 272630005198 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272630005199 N-terminal plug; other site 272630005200 ligand-binding site [chemical binding]; other site 272630005201 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 272630005202 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 272630005203 Moco binding site; other site 272630005204 metal coordination site [ion binding]; other site 272630005205 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 272630005206 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 272630005207 FAD binding pocket [chemical binding]; other site 272630005208 FAD binding motif [chemical binding]; other site 272630005209 phosphate binding motif [ion binding]; other site 272630005210 beta-alpha-beta structure motif; other site 272630005211 NAD binding pocket [chemical binding]; other site 272630005212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 272630005213 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 272630005214 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 272630005215 hinge; other site 272630005216 active site 272630005217 cytidylate kinase; Provisional; Region: cmk; PRK00023 272630005218 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272630005219 CMP-binding site; other site 272630005220 The sites determining sugar specificity; other site 272630005221 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 272630005222 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 272630005223 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 272630005224 homodimer interface [polypeptide binding]; other site 272630005225 active site 272630005226 TDP-binding site; other site 272630005227 acceptor substrate-binding pocket; other site 272630005228 Creatinine amidohydrolase; Region: Creatininase; pfam02633 272630005229 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630005230 PAS domain; Region: PAS_9; pfam13426 272630005231 putative active site [active] 272630005232 heme pocket [chemical binding]; other site 272630005233 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630005234 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630005235 metal binding site [ion binding]; metal-binding site 272630005236 active site 272630005237 I-site; other site 272630005238 CsbD-like; Region: CsbD; pfam05532 272630005239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 272630005240 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 272630005241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630005242 putative substrate translocation pore; other site 272630005243 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 272630005244 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 272630005245 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 272630005246 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 272630005247 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272630005248 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 272630005249 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 272630005250 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272630005251 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 272630005252 acyl-activating enzyme (AAE) consensus motif; other site 272630005253 acyl-activating enzyme (AAE) consensus motif; other site 272630005254 putative AMP binding site [chemical binding]; other site 272630005255 putative active site [active] 272630005256 putative CoA binding site [chemical binding]; other site 272630005257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630005258 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272630005259 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 272630005260 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630005261 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 272630005262 dimerization interface [polypeptide binding]; other site 272630005263 substrate binding pocket [chemical binding]; other site 272630005264 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 272630005265 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 272630005266 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272630005267 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272630005268 motif II; other site 272630005269 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630005270 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630005271 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272630005272 putative effector binding pocket; other site 272630005273 dimerization interface [polypeptide binding]; other site 272630005274 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 272630005275 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272630005276 Zn binding site [ion binding]; other site 272630005277 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 272630005278 Zn binding site [ion binding]; other site 272630005279 Predicted esterase [General function prediction only]; Region: COG0400 272630005280 putative hydrolase; Provisional; Region: PRK11460 272630005281 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 272630005282 AAA domain; Region: AAA_23; pfam13476 272630005283 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 272630005284 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272630005285 S17 interaction site [polypeptide binding]; other site 272630005286 S8 interaction site; other site 272630005287 16S rRNA interaction site [nucleotide binding]; other site 272630005288 streptomycin interaction site [chemical binding]; other site 272630005289 23S rRNA interaction site [nucleotide binding]; other site 272630005290 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272630005291 30S ribosomal protein S7; Validated; Region: PRK05302 272630005292 elongation factor G; Reviewed; Region: PRK00007 272630005293 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272630005294 G1 box; other site 272630005295 putative GEF interaction site [polypeptide binding]; other site 272630005296 GTP/Mg2+ binding site [chemical binding]; other site 272630005297 Switch I region; other site 272630005298 G2 box; other site 272630005299 G3 box; other site 272630005300 Switch II region; other site 272630005301 G4 box; other site 272630005302 G5 box; other site 272630005303 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272630005304 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272630005305 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272630005306 elongation factor Tu; Reviewed; Region: PRK00049 272630005307 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272630005308 G1 box; other site 272630005309 GEF interaction site [polypeptide binding]; other site 272630005310 GTP/Mg2+ binding site [chemical binding]; other site 272630005311 Switch I region; other site 272630005312 G2 box; other site 272630005313 G3 box; other site 272630005314 Switch II region; other site 272630005315 G4 box; other site 272630005316 G5 box; other site 272630005317 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272630005318 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272630005319 Antibiotic Binding Site [chemical binding]; other site 272630005320 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 272630005321 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 272630005322 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 272630005323 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 272630005324 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272630005325 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272630005326 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272630005327 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 272630005328 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272630005329 putative translocon binding site; other site 272630005330 protein-rRNA interface [nucleotide binding]; other site 272630005331 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272630005332 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272630005333 G-X-X-G motif; other site 272630005334 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272630005335 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272630005336 23S rRNA interface [nucleotide binding]; other site 272630005337 5S rRNA interface [nucleotide binding]; other site 272630005338 putative antibiotic binding site [chemical binding]; other site 272630005339 L25 interface [polypeptide binding]; other site 272630005340 L27 interface [polypeptide binding]; other site 272630005341 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272630005342 23S rRNA interface [nucleotide binding]; other site 272630005343 putative translocon interaction site; other site 272630005344 signal recognition particle (SRP54) interaction site; other site 272630005345 L23 interface [polypeptide binding]; other site 272630005346 trigger factor interaction site; other site 272630005347 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272630005348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630005349 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272630005350 Walker A motif; other site 272630005351 ATP binding site [chemical binding]; other site 272630005352 Walker B motif; other site 272630005353 arginine finger; other site 272630005354 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 272630005355 nudix motif; other site 272630005356 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272630005357 MarR family; Region: MarR; pfam01047 272630005358 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 272630005359 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 272630005360 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272630005361 alphaNTD - beta interaction site [polypeptide binding]; other site 272630005362 alphaNTD homodimer interface [polypeptide binding]; other site 272630005363 alphaNTD - beta' interaction site [polypeptide binding]; other site 272630005364 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272630005365 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272630005366 30S ribosomal protein S11; Validated; Region: PRK05309 272630005367 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 272630005368 30S ribosomal protein S13; Region: bact_S13; TIGR03631 272630005369 adenylate kinase; Reviewed; Region: adk; PRK00279 272630005370 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272630005371 AMP-binding site [chemical binding]; other site 272630005372 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272630005373 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272630005374 SecY translocase; Region: SecY; pfam00344 272630005375 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 272630005376 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 272630005377 23S rRNA binding site [nucleotide binding]; other site 272630005378 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 272630005379 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272630005380 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272630005381 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272630005382 5S rRNA interface [nucleotide binding]; other site 272630005383 23S rRNA interface [nucleotide binding]; other site 272630005384 L5 interface [polypeptide binding]; other site 272630005385 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272630005386 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272630005387 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272630005388 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 272630005389 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 272630005390 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272630005391 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272630005392 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272630005393 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 272630005394 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272630005395 RNA binding site [nucleotide binding]; other site 272630005396 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 272630005397 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 272630005398 Catalytic site; other site 272630005399 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 272630005400 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630005401 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630005402 metal binding site [ion binding]; metal-binding site 272630005403 active site 272630005404 I-site; other site 272630005405 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 272630005406 salicylate hydroxylase; Provisional; Region: PRK08163 272630005407 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272630005408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 272630005409 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272630005410 active site 272630005411 hypothetical protein; Reviewed; Region: PRK00024 272630005412 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 272630005413 MPN+ (JAMM) motif; other site 272630005414 Zinc-binding site [ion binding]; other site 272630005415 Uncharacterized conserved protein [Function unknown]; Region: COG2308 272630005416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 272630005417 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 272630005418 potential protein location (hypothetical protein; exported protein) that overlaps protein (hypothetical protein) 272630005419 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein; exported protein) 272630005420 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272630005421 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 272630005422 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272630005423 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 272630005424 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 272630005425 active site 272630005426 NAD-dependent deacetylase; Provisional; Region: PRK00481 272630005427 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 272630005428 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272630005429 Domain of unknown function DUF21; Region: DUF21; pfam01595 272630005430 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272630005431 Transporter associated domain; Region: CorC_HlyC; smart01091 272630005432 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272630005433 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272630005434 Probable Catalytic site; other site 272630005435 metal-binding site 272630005436 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630005437 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272630005438 similar to hypothetical protein; Evidence 5 : No homology to any previously reported sequences 272630005439 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 272630005440 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272630005441 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272630005442 protein binding site [polypeptide binding]; other site 272630005443 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272630005444 protein binding site [polypeptide binding]; other site 272630005445 phasin; Region: phasin_2; TIGR01985 272630005446 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630005447 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272630005448 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272630005449 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630005450 PAS domain S-box; Region: sensory_box; TIGR00229 272630005451 PAS domain; Region: PAS; smart00091 272630005452 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630005453 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630005454 metal binding site [ion binding]; metal-binding site 272630005455 active site 272630005456 I-site; other site 272630005457 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630005458 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272630005459 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272630005460 active site 272630005461 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 272630005462 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 272630005463 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 272630005464 CysD dimerization site [polypeptide binding]; other site 272630005465 G1 box; other site 272630005466 putative GEF interaction site [polypeptide binding]; other site 272630005467 GTP/Mg2+ binding site [chemical binding]; other site 272630005468 Switch I region; other site 272630005469 G2 box; other site 272630005470 G3 box; other site 272630005471 Switch II region; other site 272630005472 G4 box; other site 272630005473 G5 box; other site 272630005474 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 272630005475 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 272630005476 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 272630005477 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272630005478 Active Sites [active] 272630005479 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 272630005480 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272630005481 Active Sites [active] 272630005482 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272630005483 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272630005484 dimerization interface [polypeptide binding]; other site 272630005485 putative DNA binding site [nucleotide binding]; other site 272630005486 putative Zn2+ binding site [ion binding]; other site 272630005487 AsnC family; Region: AsnC_trans_reg; pfam01037 272630005488 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 272630005489 Flavodoxin; Region: Flavodoxin_1; pfam00258 272630005490 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 272630005491 FAD binding pocket [chemical binding]; other site 272630005492 FAD binding motif [chemical binding]; other site 272630005493 catalytic residues [active] 272630005494 NAD binding pocket [chemical binding]; other site 272630005495 phosphate binding motif [ion binding]; other site 272630005496 beta-alpha-beta structure motif; other site 272630005497 sulfite reductase subunit beta; Provisional; Region: PRK13504 272630005498 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272630005499 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272630005500 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 272630005501 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272630005502 N-terminal plug; other site 272630005503 ligand-binding site [chemical binding]; other site 272630005504 pantoate--beta-alanine ligase; Region: panC; TIGR00018 272630005505 Pantoate-beta-alanine ligase; Region: PanC; cd00560 272630005506 active site 272630005507 ATP-binding site [chemical binding]; other site 272630005508 pantoate-binding site; other site 272630005509 HXXH motif; other site 272630005510 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 272630005511 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630005512 non-specific DNA binding site [nucleotide binding]; other site 272630005513 salt bridge; other site 272630005514 sequence-specific DNA binding site [nucleotide binding]; other site 272630005515 Cupin domain; Region: Cupin_2; pfam07883 272630005516 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272630005517 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272630005518 dimer interface [polypeptide binding]; other site 272630005519 ssDNA binding site [nucleotide binding]; other site 272630005520 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272630005521 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 272630005522 Prostaglandin dehydrogenases; Region: PGDH; cd05288 272630005523 NAD(P) binding site [chemical binding]; other site 272630005524 substrate binding site [chemical binding]; other site 272630005525 dimer interface [polypeptide binding]; other site 272630005526 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 272630005527 Predicted periplasmic protein [Function unknown]; Region: COG3698 272630005528 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 272630005529 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272630005530 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 272630005531 active site 272630005532 FMN binding site [chemical binding]; other site 272630005533 substrate binding site [chemical binding]; other site 272630005534 homotetramer interface [polypeptide binding]; other site 272630005535 catalytic residue [active] 272630005536 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 272630005537 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 272630005538 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 272630005539 putative dimer interface [polypeptide binding]; other site 272630005540 N-terminal domain interface [polypeptide binding]; other site 272630005541 putative substrate binding pocket (H-site) [chemical binding]; other site 272630005542 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 272630005543 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272630005544 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 272630005545 Uncharacterized conserved protein [Function unknown]; Region: COG2835 272630005546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 272630005547 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 272630005548 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272630005549 putative active site [active] 272630005550 heme pocket [chemical binding]; other site 272630005551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630005552 dimer interface [polypeptide binding]; other site 272630005553 phosphorylation site [posttranslational modification] 272630005554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630005555 ATP binding site [chemical binding]; other site 272630005556 Mg2+ binding site [ion binding]; other site 272630005557 G-X-G motif; other site 272630005558 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 272630005559 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 272630005560 PilZ domain; Region: PilZ; pfam07238 272630005561 PilZ domain; Region: PilZ; pfam07238 272630005562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 272630005563 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 272630005564 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 272630005565 FOG: CBS domain [General function prediction only]; Region: COG0517 272630005566 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 272630005567 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 272630005568 GTP cyclohydrolase I; Provisional; Region: PLN03044 272630005569 active site 272630005570 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 272630005571 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272630005572 trimerization site [polypeptide binding]; other site 272630005573 active site 272630005574 hypothetical protein; Validated; Region: PRK00041 272630005575 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 272630005576 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 272630005577 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 272630005578 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272630005579 FtsX-like permease family; Region: FtsX; pfam02687 272630005580 FtsX-like permease family; Region: FtsX; pfam02687 272630005581 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630005582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630005583 ATP binding site [chemical binding]; other site 272630005584 Mg2+ binding site [ion binding]; other site 272630005585 G-X-G motif; other site 272630005586 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 272630005587 active site 272630005588 hydrophilic channel; other site 272630005589 dimerization interface [polypeptide binding]; other site 272630005590 catalytic residues [active] 272630005591 active site lid [active] 272630005592 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 272630005593 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272630005594 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272630005595 Catalytic site [active] 272630005596 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272630005597 Catalytic site [active] 272630005598 ribonuclease III; Reviewed; Region: rnc; PRK00102 272630005599 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272630005600 dimerization interface [polypeptide binding]; other site 272630005601 active site 272630005602 metal binding site [ion binding]; metal-binding site 272630005603 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272630005604 dsRNA binding site [nucleotide binding]; other site 272630005605 GTPase Era; Reviewed; Region: era; PRK00089 272630005606 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272630005607 G1 box; other site 272630005608 GTP/Mg2+ binding site [chemical binding]; other site 272630005609 Switch I region; other site 272630005610 G2 box; other site 272630005611 Switch II region; other site 272630005612 G3 box; other site 272630005613 G4 box; other site 272630005614 G5 box; other site 272630005615 KH domain; Region: KH_2; pfam07650 272630005616 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 272630005617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630005618 S-adenosylmethionine binding site [chemical binding]; other site 272630005619 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272630005620 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272630005621 RNA binding surface [nucleotide binding]; other site 272630005622 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 272630005623 active site 272630005624 uracil binding [chemical binding]; other site 272630005625 potassium uptake protein; Region: kup; TIGR00794 272630005626 K+ potassium transporter; Region: K_trans; pfam02705 272630005627 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 272630005628 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 272630005629 putative active site [active] 272630005630 Ap4A binding site [chemical binding]; other site 272630005631 nudix motif; other site 272630005632 putative metal binding site [ion binding]; other site 272630005633 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 272630005634 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630005635 putative CheW interface [polypeptide binding]; other site 272630005636 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 272630005637 NodB motif; other site 272630005638 putative active site [active] 272630005639 putative catalytic site [active] 272630005640 Zn binding site [ion binding]; other site 272630005641 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 272630005642 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 272630005643 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 272630005644 protein binding site [polypeptide binding]; other site 272630005645 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 272630005646 Catalytic dyad [active] 272630005647 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 272630005648 Peptidase family M23; Region: Peptidase_M23; pfam01551 272630005649 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 272630005650 citrate-proton symporter; Provisional; Region: PRK15075 272630005651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630005652 putative substrate translocation pore; other site 272630005653 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 272630005654 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630005655 metal binding site [ion binding]; metal-binding site 272630005656 active site 272630005657 I-site; other site 272630005658 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630005659 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 272630005660 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 272630005661 putative catalytic residue [active] 272630005662 argininosuccinate synthase; Provisional; Region: PRK13820 272630005663 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 272630005664 ANP binding site [chemical binding]; other site 272630005665 Substrate Binding Site II [chemical binding]; other site 272630005666 Substrate Binding Site I [chemical binding]; other site 272630005667 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 272630005668 phosphoglycolate phosphatase; Provisional; Region: PRK13222 272630005669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272630005670 motif II; other site 272630005671 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 272630005672 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272630005673 active site 272630005674 dimer interface [polypeptide binding]; other site 272630005675 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 272630005676 O-Antigen ligase; Region: Wzy_C; pfam04932 272630005677 glutathione reductase; Validated; Region: PRK06116 272630005678 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272630005679 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272630005680 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272630005681 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 272630005682 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 272630005683 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 272630005684 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 272630005685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630005686 FeS/SAM binding site; other site 272630005687 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 272630005688 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 272630005689 Fe-S cluster binding site [ion binding]; other site 272630005690 active site 272630005691 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 272630005692 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272630005693 NAD binding site [chemical binding]; other site 272630005694 catalytic Zn binding site [ion binding]; other site 272630005695 structural Zn binding site [ion binding]; other site 272630005696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 272630005697 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 272630005698 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272630005699 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272630005700 catalytic residue [active] 272630005701 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 272630005702 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272630005703 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 272630005704 putative C-terminal domain interface [polypeptide binding]; other site 272630005705 putative GSH binding site (G-site) [chemical binding]; other site 272630005706 putative dimer interface [polypeptide binding]; other site 272630005707 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 272630005708 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 272630005709 putative heme binding pocket [chemical binding]; other site 272630005710 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272630005711 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 272630005712 putative FMN binding site [chemical binding]; other site 272630005713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272630005714 DNA-binding site [nucleotide binding]; DNA binding site 272630005715 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272630005716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272630005717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630005718 homodimer interface [polypeptide binding]; other site 272630005719 catalytic residue [active] 272630005720 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 272630005721 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 272630005722 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 272630005723 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272630005724 active site 272630005725 dimer interface [polypeptide binding]; other site 272630005726 motif 1; other site 272630005727 motif 2; other site 272630005728 motif 3; other site 272630005729 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272630005730 anticodon binding site; other site 272630005731 fructokinase; Reviewed; Region: PRK09557 272630005732 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272630005733 nucleotide binding site [chemical binding]; other site 272630005734 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 272630005735 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272630005736 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 272630005737 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272630005738 active site 272630005739 HIGH motif; other site 272630005740 nucleotide binding site [chemical binding]; other site 272630005741 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272630005742 active site 272630005743 KMSKS motif; other site 272630005744 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 272630005745 tRNA binding surface [nucleotide binding]; other site 272630005746 anticodon binding site; other site 272630005747 lipoprotein signal peptidase; Provisional; Region: PRK14796 272630005748 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272630005749 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272630005750 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272630005751 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272630005752 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272630005753 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 272630005754 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272630005755 Zn binding site [ion binding]; other site 272630005756 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 272630005757 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272630005758 Zn binding site [ion binding]; other site 272630005759 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 272630005760 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 272630005761 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 272630005762 FAD binding pocket [chemical binding]; other site 272630005763 FAD binding motif [chemical binding]; other site 272630005764 phosphate binding motif [ion binding]; other site 272630005765 beta-alpha-beta structure motif; other site 272630005766 NAD binding pocket [chemical binding]; other site 272630005767 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 272630005768 AAA domain; Region: AAA_26; pfam13500 272630005769 Response regulator receiver domain; Region: Response_reg; pfam00072 272630005770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630005771 active site 272630005772 phosphorylation site [posttranslational modification] 272630005773 intermolecular recognition site; other site 272630005774 dimerization interface [polypeptide binding]; other site 272630005775 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 272630005776 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272630005777 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 272630005778 structural tetrad; other site 272630005779 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 272630005780 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 272630005781 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 272630005782 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 272630005783 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 272630005784 feedback inhibition sensing region; other site 272630005785 homohexameric interface [polypeptide binding]; other site 272630005786 nucleotide binding site [chemical binding]; other site 272630005787 N-acetyl-L-glutamate binding site [chemical binding]; other site 272630005788 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 272630005789 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 272630005790 MOSC domain; Region: MOSC; pfam03473 272630005791 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 272630005792 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 272630005793 MOSC domain; Region: MOSC; pfam03473 272630005794 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 272630005795 Clp amino terminal domain; Region: Clp_N; pfam02861 272630005796 Clp amino terminal domain; Region: Clp_N; pfam02861 272630005797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630005798 Walker A motif; other site 272630005799 ATP binding site [chemical binding]; other site 272630005800 Walker B motif; other site 272630005801 arginine finger; other site 272630005802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630005803 Walker A motif; other site 272630005804 ATP binding site [chemical binding]; other site 272630005805 Walker B motif; other site 272630005806 arginine finger; other site 272630005807 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272630005808 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 272630005809 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272630005810 active site 272630005811 metal binding site [ion binding]; metal-binding site 272630005812 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 272630005813 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 272630005814 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 272630005815 G1 box; other site 272630005816 GTP/Mg2+ binding site [chemical binding]; other site 272630005817 Switch I region; other site 272630005818 G2 box; other site 272630005819 G3 box; other site 272630005820 Switch II region; other site 272630005821 G4 box; other site 272630005822 G5 box; other site 272630005823 membrane protein insertase; Provisional; Region: PRK01318 272630005824 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 272630005825 Ribonuclease P; Region: Ribonuclease_P; pfam00825 272630005826 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 272630005827 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 272630005828 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 272630005829 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 272630005830 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272630005831 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 272630005832 Walker A/P-loop; other site 272630005833 ATP binding site [chemical binding]; other site 272630005834 Q-loop/lid; other site 272630005835 ABC transporter signature motif; other site 272630005836 Walker B; other site 272630005837 D-loop; other site 272630005838 H-loop/switch region; other site 272630005839 D-cysteine desulfhydrase; Validated; Region: PRK03910 272630005840 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 272630005841 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272630005842 catalytic residue [active] 272630005843 hypothetical protein; Validated; Region: PRK09039 272630005844 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272630005845 ligand binding site [chemical binding]; other site 272630005846 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 272630005847 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272630005848 putative active site [active] 272630005849 metal binding site [ion binding]; metal-binding site 272630005850 homodimer binding site [polypeptide binding]; other site 272630005851 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 272630005852 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 272630005853 Cell division protein ZapA; Region: ZapA; pfam05164 272630005854 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 272630005855 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 272630005856 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272630005857 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272630005858 Phosphoglycerate kinase; Region: PGK; pfam00162 272630005859 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 272630005860 substrate binding site [chemical binding]; other site 272630005861 hinge regions; other site 272630005862 ADP binding site [chemical binding]; other site 272630005863 catalytic site [active] 272630005864 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 272630005865 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272630005866 intersubunit interface [polypeptide binding]; other site 272630005867 active site 272630005868 zinc binding site [ion binding]; other site 272630005869 Na+ binding site [ion binding]; other site 272630005870 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272630005871 active site 272630005872 thiamine phosphate binding site [chemical binding]; other site 272630005873 pyrophosphate binding site [ion binding]; other site 272630005874 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272630005875 Sel1-like repeats; Region: SEL1; smart00671 272630005876 Sel1 repeat; Region: Sel1; cl02723 272630005877 Sel1-like repeats; Region: SEL1; smart00671 272630005878 amino acid transporter; Region: 2A0306; TIGR00909 272630005879 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 272630005880 Uncharacterized conserved protein [Function unknown]; Region: COG0062 272630005881 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 272630005882 putative substrate binding site [chemical binding]; other site 272630005883 putative ATP binding site [chemical binding]; other site 272630005884 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 272630005885 Nitrogen regulatory protein P-II; Region: P-II; smart00938 272630005886 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 272630005887 glutaminase; Provisional; Region: PRK00971 272630005888 glutamine synthetase; Region: PLN02284 272630005889 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 272630005890 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272630005891 glutamine synthetase; Provisional; Region: glnA; PRK09469 272630005892 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 272630005893 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272630005894 Predicted flavoprotein [General function prediction only]; Region: COG0431 272630005895 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272630005896 ribonuclease R; Region: RNase_R; TIGR02063 272630005897 RNB domain; Region: RNB; pfam00773 272630005898 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 272630005899 RNA binding site [nucleotide binding]; other site 272630005900 Protein of unknown function (DUF983); Region: DUF983; cl02211 272630005901 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 272630005902 nudix motif; other site 272630005903 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630005904 PAS domain; Region: PAS_9; pfam13426 272630005905 putative active site [active] 272630005906 heme pocket [chemical binding]; other site 272630005907 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630005908 PAS domain; Region: PAS_9; pfam13426 272630005909 putative active site [active] 272630005910 heme pocket [chemical binding]; other site 272630005911 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630005912 PAS domain; Region: PAS_9; pfam13426 272630005913 putative active site [active] 272630005914 heme pocket [chemical binding]; other site 272630005915 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630005916 dimer interface [polypeptide binding]; other site 272630005917 putative CheW interface [polypeptide binding]; other site 272630005918 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 272630005919 putative NAD(P) binding site [chemical binding]; other site 272630005920 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272630005921 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 272630005922 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 272630005923 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272630005924 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 272630005925 C-terminal domain interface [polypeptide binding]; other site 272630005926 GSH binding site (G-site) [chemical binding]; other site 272630005927 dimer interface [polypeptide binding]; other site 272630005928 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 272630005929 N-terminal domain interface [polypeptide binding]; other site 272630005930 dimer interface [polypeptide binding]; other site 272630005931 substrate binding pocket (H-site) [chemical binding]; other site 272630005932 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 272630005933 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 272630005934 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 272630005935 heterodimer interface [polypeptide binding]; other site 272630005936 substrate interaction site [chemical binding]; other site 272630005937 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 272630005938 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 272630005939 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 272630005940 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 272630005941 NAD binding site [chemical binding]; other site 272630005942 substrate binding site [chemical binding]; other site 272630005943 homodimer interface [polypeptide binding]; other site 272630005944 active site 272630005945 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 272630005946 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 272630005947 NADP binding site [chemical binding]; other site 272630005948 active site 272630005949 putative substrate binding site [chemical binding]; other site 272630005950 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 272630005951 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 272630005952 substrate binding site; other site 272630005953 tetramer interface; other site 272630005954 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272630005955 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630005956 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898 272630005957 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 272630005958 Peptidase family M50; Region: Peptidase_M50; pfam02163 272630005959 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 272630005960 active site 272630005961 putative substrate binding region [chemical binding]; other site 272630005962 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272630005963 GAF domain; Region: GAF_3; pfam13492 272630005964 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272630005965 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630005966 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 272630005967 O-methyltransferase; Region: Methyltransf_2; pfam00891 272630005968 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 272630005969 AAA domain; Region: AAA_33; pfam13671 272630005970 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 272630005971 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 272630005972 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630005973 FeS/SAM binding site; other site 272630005974 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272630005975 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272630005976 SapC; Region: SapC; pfam07277 272630005977 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272630005978 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272630005979 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272630005980 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272630005981 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 272630005982 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 272630005983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630005984 S-adenosylmethionine binding site [chemical binding]; other site 272630005985 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 272630005986 B12 binding site [chemical binding]; other site 272630005987 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 272630005988 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630005989 FeS/SAM binding site; other site 272630005990 B12 binding domain; Region: B12-binding; pfam02310 272630005991 B12 binding site [chemical binding]; other site 272630005992 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630005993 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272630005994 FeS/SAM binding site; other site 272630005995 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 272630005996 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 272630005997 Multicopper oxidase; Region: Cu-oxidase; pfam00394 272630005998 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 272630005999 trigger factor; Provisional; Region: tig; PRK01490 272630006000 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272630006001 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272630006002 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 272630006003 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272630006004 oligomer interface [polypeptide binding]; other site 272630006005 active site residues [active] 272630006006 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 272630006007 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 272630006008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630006009 Walker A motif; other site 272630006010 ATP binding site [chemical binding]; other site 272630006011 Walker B motif; other site 272630006012 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272630006013 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 272630006014 Found in ATP-dependent protease La (LON); Region: LON; smart00464 272630006015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630006016 Walker A motif; other site 272630006017 ATP binding site [chemical binding]; other site 272630006018 Walker B motif; other site 272630006019 arginine finger; other site 272630006020 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272630006021 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 272630006022 putative ADP-binding pocket [chemical binding]; other site 272630006023 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630006024 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 272630006025 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 272630006026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630006027 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272630006028 S-adenosylmethionine binding site [chemical binding]; other site 272630006029 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 272630006030 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 272630006031 OPT oligopeptide transporter protein; Region: OPT; cl14607 272630006032 putative oligopeptide transporter, OPT family; Region: TIGR00733 272630006033 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272630006034 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272630006035 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 272630006036 5'-3' exonuclease; Region: 53EXOc; smart00475 272630006037 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272630006038 active site 272630006039 metal binding site 1 [ion binding]; metal-binding site 272630006040 putative 5' ssDNA interaction site; other site 272630006041 metal binding site 3; metal-binding site 272630006042 metal binding site 2 [ion binding]; metal-binding site 272630006043 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272630006044 putative DNA binding site [nucleotide binding]; other site 272630006045 putative metal binding site [ion binding]; other site 272630006046 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 272630006047 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 272630006048 active site 272630006049 catalytic site [active] 272630006050 substrate binding site [chemical binding]; other site 272630006051 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272630006052 active site 272630006053 DNA binding site [nucleotide binding] 272630006054 catalytic site [active] 272630006055 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 272630006056 Active_site [active] 272630006057 GTP-binding protein YchF; Reviewed; Region: PRK09601 272630006058 YchF GTPase; Region: YchF; cd01900 272630006059 G1 box; other site 272630006060 GTP/Mg2+ binding site [chemical binding]; other site 272630006061 Switch I region; other site 272630006062 G2 box; other site 272630006063 Switch II region; other site 272630006064 G3 box; other site 272630006065 G4 box; other site 272630006066 G5 box; other site 272630006067 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272630006068 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272630006069 putative active site [active] 272630006070 catalytic residue [active] 272630006071 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 272630006072 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 272630006073 5S rRNA interface [nucleotide binding]; other site 272630006074 CTC domain interface [polypeptide binding]; other site 272630006075 L16 interface [polypeptide binding]; other site 272630006076 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 272630006077 Flp/Fap pilin component; Region: Flp_Fap; cl01585 272630006078 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 272630006079 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 272630006080 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 272630006081 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 272630006082 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 272630006083 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 272630006084 Type IV pili component [Cell motility and secretion]; Region: COG5461 272630006085 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 272630006086 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 272630006087 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 272630006088 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 272630006089 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 272630006090 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 272630006091 ATP binding site [chemical binding]; other site 272630006092 Walker A motif; other site 272630006093 hexamer interface [polypeptide binding]; other site 272630006094 Walker B motif; other site 272630006095 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 272630006096 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272630006097 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 272630006098 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272630006099 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 272630006100 putative active site [active] 272630006101 putative catalytic site [active] 272630006102 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 272630006103 putative active site [active] 272630006104 putative catalytic site [active] 272630006105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630006106 metabolite-proton symporter; Region: 2A0106; TIGR00883 272630006107 putative substrate translocation pore; other site 272630006108 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 272630006109 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 272630006110 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272630006111 CoenzymeA binding site [chemical binding]; other site 272630006112 subunit interaction site [polypeptide binding]; other site 272630006113 PHB binding site; other site 272630006114 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272630006115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630006116 putative substrate translocation pore; other site 272630006117 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630006118 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630006119 metal binding site [ion binding]; metal-binding site 272630006120 active site 272630006121 I-site; other site 272630006122 BA14K-like protein; Region: BA14K; pfam07886 272630006123 CsbD-like; Region: CsbD; pfam05532 272630006124 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 272630006125 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 272630006126 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 272630006127 catalytic site [active] 272630006128 putative active site [active] 272630006129 putative substrate binding site [chemical binding]; other site 272630006130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 272630006131 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 272630006132 OstA-like protein; Region: OstA; pfam03968 272630006133 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 272630006134 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 272630006135 Walker A/P-loop; other site 272630006136 ATP binding site [chemical binding]; other site 272630006137 Q-loop/lid; other site 272630006138 ABC transporter signature motif; other site 272630006139 Walker B; other site 272630006140 D-loop; other site 272630006141 H-loop/switch region; other site 272630006142 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 272630006143 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 272630006144 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 272630006145 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 272630006146 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 272630006147 30S subunit binding site; other site 272630006148 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272630006149 active site 272630006150 phosphorylation site [posttranslational modification] 272630006151 magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407 272630006152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630006153 Walker A motif; other site 272630006154 ATP binding site [chemical binding]; other site 272630006155 Walker B motif; other site 272630006156 arginine finger; other site 272630006157 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272630006158 catalytic core [active] 272630006159 dihydrodipicolinate reductase; Provisional; Region: PRK00048 272630006160 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 272630006161 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 272630006162 MarC family integral membrane protein; Region: MarC; cl00919 272630006163 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272630006164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630006165 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 272630006166 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 272630006167 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272630006168 active site 272630006169 DNA binding site [nucleotide binding] 272630006170 Int/Topo IB signature motif; other site 272630006171 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630006172 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630006173 metal binding site [ion binding]; metal-binding site 272630006174 active site 272630006175 I-site; other site 272630006176 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 272630006177 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 272630006178 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 272630006179 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 272630006180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630006181 dimer interface [polypeptide binding]; other site 272630006182 conserved gate region; other site 272630006183 ABC-ATPase subunit interface; other site 272630006184 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 272630006185 hypothetical protein; Provisional; Region: PRK08912 272630006186 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272630006187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630006188 homodimer interface [polypeptide binding]; other site 272630006189 catalytic residue [active] 272630006190 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272630006191 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272630006192 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630006193 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 272630006194 Protein export membrane protein; Region: SecD_SecF; cl14618 272630006195 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 272630006196 Protein export membrane protein; Region: SecD_SecF; cl14618 272630006197 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272630006198 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 272630006199 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 272630006200 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 272630006201 tartrate dehydrogenase; Region: TTC; TIGR02089 272630006202 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 272630006203 benzoylformate decarboxylase; Reviewed; Region: PRK07092 272630006204 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272630006205 PYR/PP interface [polypeptide binding]; other site 272630006206 dimer interface [polypeptide binding]; other site 272630006207 TPP binding site [chemical binding]; other site 272630006208 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272630006209 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 272630006210 TPP-binding site [chemical binding]; other site 272630006211 dimer interface [polypeptide binding]; other site 272630006212 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 272630006213 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272630006214 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272630006215 substrate binding pocket [chemical binding]; other site 272630006216 chain length determination region; other site 272630006217 substrate-Mg2+ binding site; other site 272630006218 catalytic residues [active] 272630006219 aspartate-rich region 1; other site 272630006220 active site lid residues [active] 272630006221 aspartate-rich region 2; other site 272630006222 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 272630006223 Transglycosylase; Region: Transgly; cl17702 272630006224 photolyase PhrII; Region: phr2; TIGR00591 272630006225 DNA photolyase; Region: DNA_photolyase; pfam00875 272630006226 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 272630006227 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 272630006228 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 272630006229 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 272630006230 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 272630006231 dimerization interface [polypeptide binding]; other site 272630006232 ligand binding site [chemical binding]; other site 272630006233 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 272630006234 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 272630006235 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 272630006236 Sulfatase; Region: Sulfatase; cl17466 272630006237 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 272630006238 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 272630006239 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 272630006240 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272630006241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630006242 NAD(P) binding site [chemical binding]; other site 272630006243 active site 272630006244 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 272630006245 active site 272630006246 cosubstrate binding site; other site 272630006247 substrate binding site [chemical binding]; other site 272630006248 catalytic site [active] 272630006249 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 272630006250 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272630006251 homodimer interface [polypeptide binding]; other site 272630006252 substrate-cofactor binding pocket; other site 272630006253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630006254 catalytic residue [active] 272630006255 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 272630006256 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 272630006257 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 272630006258 [2Fe-2S] cluster binding site [ion binding]; other site 272630006259 cytochrome b; Provisional; Region: CYTB; MTH00191 272630006260 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 272630006261 Qi binding site; other site 272630006262 intrachain domain interface; other site 272630006263 interchain domain interface [polypeptide binding]; other site 272630006264 heme bH binding site [chemical binding]; other site 272630006265 heme bL binding site [chemical binding]; other site 272630006266 Qo binding site; other site 272630006267 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 272630006268 interchain domain interface [polypeptide binding]; other site 272630006269 intrachain domain interface; other site 272630006270 Qi binding site; other site 272630006271 Qo binding site; other site 272630006272 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 272630006273 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 272630006274 Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396 272630006275 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272630006276 active site 272630006277 metal binding site [ion binding]; metal-binding site 272630006278 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 272630006279 4-fold oligomerization interface [polypeptide binding]; other site 272630006280 putative active site pocket [active] 272630006281 metal binding residues [ion binding]; metal-binding site 272630006282 3-fold/trimer interface [polypeptide binding]; other site 272630006283 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 272630006284 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 272630006285 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 272630006286 putative active site [active] 272630006287 oxyanion strand; other site 272630006288 catalytic triad [active] 272630006289 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 272630006290 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 272630006291 catalytic residues [active] 272630006292 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 272630006293 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 272630006294 substrate binding site [chemical binding]; other site 272630006295 glutamase interaction surface [polypeptide binding]; other site 272630006296 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 272630006297 metal binding site [ion binding]; metal-binding site 272630006298 pantothenate kinase; Provisional; Region: PRK05439 272630006299 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 272630006300 ATP-binding site [chemical binding]; other site 272630006301 CoA-binding site [chemical binding]; other site 272630006302 Mg2+-binding site [ion binding]; other site 272630006303 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630006304 dimerization interface [polypeptide binding]; other site 272630006305 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630006306 dimer interface [polypeptide binding]; other site 272630006307 putative CheW interface [polypeptide binding]; other site 272630006308 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272630006309 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272630006310 catalytic residue [active] 272630006311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630006312 Response regulator receiver domain; Region: Response_reg; pfam00072 272630006313 active site 272630006314 phosphorylation site [posttranslational modification] 272630006315 intermolecular recognition site; other site 272630006316 dimerization interface [polypeptide binding]; other site 272630006317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272630006318 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630006319 phasin; Region: phasin_2; TIGR01985 272630006320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630006321 putative active site [active] 272630006322 heme pocket [chemical binding]; other site 272630006323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630006324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630006325 ATP binding site [chemical binding]; other site 272630006326 Mg2+ binding site [ion binding]; other site 272630006327 G-X-G motif; other site 272630006328 acetyl-CoA synthetase; Provisional; Region: PRK00174 272630006329 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 272630006330 active site 272630006331 CoA binding site [chemical binding]; other site 272630006332 acyl-activating enzyme (AAE) consensus motif; other site 272630006333 AMP binding site [chemical binding]; other site 272630006334 acetate binding site [chemical binding]; other site 272630006335 Protein of unknown function, DUF485; Region: DUF485; pfam04341 272630006336 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 272630006337 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 272630006338 Na binding site [ion binding]; other site 272630006339 metabolite-proton symporter; Region: 2A0106; TIGR00883 272630006340 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 272630006341 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 272630006342 purine monophosphate binding site [chemical binding]; other site 272630006343 dimer interface [polypeptide binding]; other site 272630006344 putative catalytic residues [active] 272630006345 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 272630006346 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 272630006347 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 272630006348 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 272630006349 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 272630006350 active site residue [active] 272630006351 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 272630006352 active site residue [active] 272630006353 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272630006354 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272630006355 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272630006356 ATP binding site [chemical binding]; other site 272630006357 Mg++ binding site [ion binding]; other site 272630006358 motif III; other site 272630006359 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630006360 nucleotide binding region [chemical binding]; other site 272630006361 ATP-binding site [chemical binding]; other site 272630006362 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 272630006363 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 272630006364 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272630006365 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 272630006366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630006367 Mg2+ binding site [ion binding]; other site 272630006368 G-X-G motif; other site 272630006369 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272630006370 anchoring element; other site 272630006371 dimer interface [polypeptide binding]; other site 272630006372 ATP binding site [chemical binding]; other site 272630006373 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272630006374 active site 272630006375 putative metal-binding site [ion binding]; other site 272630006376 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272630006377 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 272630006378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272630006379 Coenzyme A binding pocket [chemical binding]; other site 272630006380 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 272630006381 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 272630006382 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 272630006383 Domain of unknown function (DUF336); Region: DUF336; cl01249 272630006384 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272630006385 dimerization interface [polypeptide binding]; other site 272630006386 putative DNA binding site [nucleotide binding]; other site 272630006387 putative Zn2+ binding site [ion binding]; other site 272630006388 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272630006389 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 272630006390 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 272630006391 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 272630006392 catalytic residues [active] 272630006393 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272630006394 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 272630006395 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 272630006396 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 272630006397 Cytochrome c [Energy production and conversion]; Region: COG3258 272630006398 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 272630006399 active site 272630006400 metal binding site [ion binding]; metal-binding site 272630006401 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272630006402 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272630006403 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 272630006404 Moco binding site; other site 272630006405 metal coordination site [ion binding]; other site 272630006406 dimerization interface [polypeptide binding]; other site 272630006407 Cytochrome c; Region: Cytochrom_C; pfam00034 272630006408 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272630006409 DsrE/DsrF-like family; Region: DrsE; pfam02635 272630006410 DsrE/DsrF-like family; Region: DrsE; cl00672 272630006411 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 272630006412 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272630006413 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272630006414 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272630006415 catalytic residues [active] 272630006416 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272630006417 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272630006418 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272630006419 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272630006420 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272630006421 Cytochrome c [Energy production and conversion]; Region: COG3258 272630006422 Cytochrome c; Region: Cytochrom_C; pfam00034 272630006423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272630006424 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630006425 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 272630006426 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 272630006427 catalytic residues [active] 272630006428 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 272630006429 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 272630006430 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 272630006431 DsbD alpha interface [polypeptide binding]; other site 272630006432 catalytic residues [active] 272630006433 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 272630006434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630006435 active site 272630006436 phosphorylation site [posttranslational modification] 272630006437 intermolecular recognition site; other site 272630006438 dimerization interface [polypeptide binding]; other site 272630006439 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630006440 DNA binding site [nucleotide binding] 272630006441 sensor protein QseC; Provisional; Region: PRK10337 272630006442 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630006443 dimer interface [polypeptide binding]; other site 272630006444 phosphorylation site [posttranslational modification] 272630006445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630006446 ATP binding site [chemical binding]; other site 272630006447 Mg2+ binding site [ion binding]; other site 272630006448 G-X-G motif; other site 272630006449 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 272630006450 active site residue [active] 272630006451 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272630006452 Predicted transporter component [General function prediction only]; Region: COG2391 272630006453 Sulphur transport; Region: Sulf_transp; pfam04143 272630006454 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 272630006455 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272630006456 dimerization interface [polypeptide binding]; other site 272630006457 putative Zn2+ binding site [ion binding]; other site 272630006458 putative DNA binding site [nucleotide binding]; other site 272630006459 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 272630006460 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272630006461 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272630006462 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272630006463 putative Mg++ binding site [ion binding]; other site 272630006464 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630006465 nucleotide binding region [chemical binding]; other site 272630006466 ATP-binding site [chemical binding]; other site 272630006467 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 272630006468 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 272630006469 tellurium resistance terB-like protein; Region: terB_like; cl11965 272630006470 metal binding site [ion binding]; metal-binding site 272630006471 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 272630006472 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272630006473 Zn2+ binding site [ion binding]; other site 272630006474 Mg2+ binding site [ion binding]; other site 272630006475 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 272630006476 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 272630006477 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 272630006478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 272630006479 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 272630006480 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 272630006481 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272630006482 metal-binding site [ion binding] 272630006483 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272630006484 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272630006485 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 272630006486 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 272630006487 DNA binding residues [nucleotide binding] 272630006488 dimer interface [polypeptide binding]; other site 272630006489 putative metal binding site [ion binding]; other site 272630006490 YHS domain; Region: YHS; pfam04945 272630006491 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272630006492 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272630006493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272630006494 motif II; other site 272630006495 Domain of unknown function (DUF305); Region: DUF305; cl17794 272630006496 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 272630006497 dimerization interface [polypeptide binding]; other site 272630006498 Domain of unknown function (DUF305); Region: DUF305; cl17794 272630006499 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 272630006500 Protein export membrane protein; Region: SecD_SecF; cl14618 272630006501 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 272630006502 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630006503 serine/threonine kinase US3; Provisional; Region: PHA03212 272630006504 High-affinity nickel-transport protein; Region: NicO; cl00964 272630006505 High-affinity nickel-transport protein; Region: NicO; cl00964 272630006506 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 272630006507 putative metal binding site [ion binding]; other site 272630006508 putative homodimer interface [polypeptide binding]; other site 272630006509 putative homotetramer interface [polypeptide binding]; other site 272630006510 putative homodimer-homodimer interface [polypeptide binding]; other site 272630006511 putative allosteric switch controlling residues; other site 272630006512 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 272630006513 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 272630006514 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 272630006515 DNA binding residues [nucleotide binding] 272630006516 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272630006517 metal-binding site [ion binding] 272630006518 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272630006519 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272630006520 metal-binding site [ion binding] 272630006521 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272630006522 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272630006523 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272630006524 metal-binding site [ion binding] 272630006525 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272630006526 metal-binding site [ion binding] 272630006527 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 272630006528 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 272630006529 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272630006530 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272630006531 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 272630006532 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 272630006533 DNA binding residues [nucleotide binding] 272630006534 dimer interface [polypeptide binding]; other site 272630006535 putative metal binding site [ion binding]; other site 272630006536 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 272630006537 MerT mercuric transport protein; Region: MerT; cl03578 272630006538 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272630006539 metal-binding site [ion binding] 272630006540 mercuric reductase; Region: MerA; TIGR02053 272630006541 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272630006542 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272630006543 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 272630006544 MPT binding site; other site 272630006545 trimer interface [polypeptide binding]; other site 272630006546 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 272630006547 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 272630006548 catalytic residues [active] 272630006549 Thioredoxin; Region: Thioredoxin_4; pfam13462 272630006550 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 272630006551 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 272630006552 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272630006553 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272630006554 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 272630006555 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272630006556 catalytic residues [active] 272630006557 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272630006558 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272630006559 FtsX-like permease family; Region: FtsX; pfam02687 272630006560 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272630006561 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272630006562 Walker A/P-loop; other site 272630006563 ATP binding site [chemical binding]; other site 272630006564 Q-loop/lid; other site 272630006565 ABC transporter signature motif; other site 272630006566 Walker B; other site 272630006567 D-loop; other site 272630006568 H-loop/switch region; other site 272630006569 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 272630006570 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 272630006571 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272630006572 dimerization interface [polypeptide binding]; other site 272630006573 putative DNA binding site [nucleotide binding]; other site 272630006574 putative Zn2+ binding site [ion binding]; other site 272630006575 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272630006576 active site 272630006577 metal binding site [ion binding]; metal-binding site 272630006578 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272630006579 active site 272630006580 metal binding site [ion binding]; metal-binding site 272630006581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630006582 non-specific DNA binding site [nucleotide binding]; other site 272630006583 salt bridge; other site 272630006584 sequence-specific DNA binding site [nucleotide binding]; other site 272630006585 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 272630006586 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630006587 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 272630006588 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272630006589 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 272630006590 ligand binding site [chemical binding]; other site 272630006591 flexible hinge region; other site 272630006592 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272630006593 putative switch regulator; other site 272630006594 non-specific DNA interactions [nucleotide binding]; other site 272630006595 DNA binding site [nucleotide binding] 272630006596 sequence specific DNA binding site [nucleotide binding]; other site 272630006597 putative cAMP binding site [chemical binding]; other site 272630006598 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 272630006599 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 272630006600 MgtC family; Region: MgtC; pfam02308 272630006601 TPR repeat; Region: TPR_11; pfam13414 272630006602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272630006603 TPR motif; other site 272630006604 binding surface 272630006605 TPR repeat; Region: TPR_11; pfam13414 272630006606 TPR repeat; Region: TPR_11; pfam13414 272630006607 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272630006608 TPR motif; other site 272630006609 binding surface 272630006610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630006611 S-adenosylmethionine binding site [chemical binding]; other site 272630006612 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 272630006613 Flagellin N-methylase; Region: FliB; pfam03692 272630006614 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 272630006615 Integrase core domain; Region: rve; pfam00665 272630006616 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 272630006617 AAA domain; Region: AAA_22; pfam13401 272630006618 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 272630006619 TniQ; Region: TniQ; pfam06527 272630006620 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 272630006621 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 272630006622 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 272630006623 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 272630006624 Predicted metal binding domain; Region: Metal_CEHH; pfam14455 272630006625 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 272630006626 E1 N-terminal domain; Region: E1-N; pfam14463 272630006627 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 272630006628 ATP binding site [chemical binding]; other site 272630006629 RNA polymerase sigma factor; Provisional; Region: PRK12547 272630006630 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630006631 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272630006632 DNA binding residues [nucleotide binding] 272630006633 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 272630006634 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 272630006635 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 272630006636 aspartate aminotransferase; Provisional; Region: PRK05764 272630006637 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272630006638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630006639 homodimer interface [polypeptide binding]; other site 272630006640 catalytic residue [active] 272630006641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630006642 HAMP domain; Region: HAMP; pfam00672 272630006643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630006644 dimer interface [polypeptide binding]; other site 272630006645 phosphorylation site [posttranslational modification] 272630006646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630006647 ATP binding site [chemical binding]; other site 272630006648 Mg2+ binding site [ion binding]; other site 272630006649 G-X-G motif; other site 272630006650 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272630006651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630006652 active site 272630006653 phosphorylation site [posttranslational modification] 272630006654 intermolecular recognition site; other site 272630006655 dimerization interface [polypeptide binding]; other site 272630006656 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630006657 DNA binding site [nucleotide binding] 272630006658 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272630006659 MarR family; Region: MarR_2; pfam12802 272630006660 branched-chain amino acid aminotransferase; Validated; Region: PRK07544 272630006661 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 272630006662 homodimer interface [polypeptide binding]; other site 272630006663 substrate-cofactor binding pocket; other site 272630006664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630006665 catalytic residue [active] 272630006666 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 272630006667 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 272630006668 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 272630006669 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272630006670 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 272630006671 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 272630006672 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 272630006673 TrkA-N domain; Region: TrkA_N; pfam02254 272630006674 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 272630006675 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 272630006676 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 272630006677 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 272630006678 putative active site [active] 272630006679 putative substrate binding site [chemical binding]; other site 272630006680 ATP binding site [chemical binding]; other site 272630006681 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 272630006682 catalytic triad [active] 272630006683 dimer interface [polypeptide binding]; other site 272630006684 hypothetical protein; Validated; Region: PRK00228 272630006685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 272630006686 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 272630006687 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272630006688 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272630006689 motif 1; other site 272630006690 active site 272630006691 motif 2; other site 272630006692 motif 3; other site 272630006693 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272630006694 Predicted transcriptional regulator [Transcription]; Region: COG2378 272630006695 HTH domain; Region: HTH_11; pfam08279 272630006696 WYL domain; Region: WYL; pfam13280 272630006697 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272630006698 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272630006699 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 272630006700 dimer interface [polypeptide binding]; other site 272630006701 N-terminal domain interface [polypeptide binding]; other site 272630006702 putative substrate binding pocket (H-site) [chemical binding]; other site 272630006703 recombinase A; Provisional; Region: recA; PRK09354 272630006704 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272630006705 hexamer interface [polypeptide binding]; other site 272630006706 Walker A motif; other site 272630006707 ATP binding site [chemical binding]; other site 272630006708 Walker B motif; other site 272630006709 PAS domain; Region: PAS_9; pfam13426 272630006710 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272630006711 PAS domain; Region: PAS_8; pfam13188 272630006712 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272630006713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630006714 dimer interface [polypeptide binding]; other site 272630006715 phosphorylation site [posttranslational modification] 272630006716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630006717 ATP binding site [chemical binding]; other site 272630006718 Mg2+ binding site [ion binding]; other site 272630006719 G-X-G motif; other site 272630006720 Response regulator receiver domain; Region: Response_reg; pfam00072 272630006721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630006722 active site 272630006723 phosphorylation site [posttranslational modification] 272630006724 intermolecular recognition site; other site 272630006725 dimerization interface [polypeptide binding]; other site 272630006726 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 272630006727 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 272630006728 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 272630006729 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 272630006730 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 272630006731 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 272630006732 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272630006733 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272630006734 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 272630006735 Predicted dehydrogenase [General function prediction only]; Region: COG0579 272630006736 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272630006737 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272630006738 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272630006739 heme exporter protein CcmC; Region: ccmC; TIGR01191 272630006740 Heme exporter protein D (CcmD); Region: CcmD; pfam04995 272630006741 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 272630006742 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 272630006743 catalytic residues [active] 272630006744 central insert; other site 272630006745 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 272630006746 Cysteine-rich domain; Region: CCG; pfam02754 272630006747 Cysteine-rich domain; Region: CCG; pfam02754 272630006748 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 272630006749 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 272630006750 4Fe-4S binding domain; Region: Fer4; pfam00037 272630006751 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 272630006752 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272630006753 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272630006754 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272630006755 23S rRNA interface [nucleotide binding]; other site 272630006756 L3 interface [polypeptide binding]; other site 272630006757 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 272630006758 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 272630006759 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 272630006760 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 272630006761 active site 272630006762 catalytic residues [active] 272630006763 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272630006764 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630006765 Walker A/P-loop; other site 272630006766 ATP binding site [chemical binding]; other site 272630006767 Q-loop/lid; other site 272630006768 ABC transporter signature motif; other site 272630006769 Walker B; other site 272630006770 D-loop; other site 272630006771 H-loop/switch region; other site 272630006772 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 272630006773 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 272630006774 MOFRL family; Region: MOFRL; pfam05161 272630006775 pyruvate kinase; Provisional; Region: PRK06247 272630006776 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 272630006777 domain interfaces; other site 272630006778 active site 272630006779 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630006780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630006781 ATP binding site [chemical binding]; other site 272630006782 Mg2+ binding site [ion binding]; other site 272630006783 G-X-G motif; other site 272630006784 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272630006785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630006786 active site 272630006787 phosphorylation site [posttranslational modification] 272630006788 intermolecular recognition site; other site 272630006789 dimerization interface [polypeptide binding]; other site 272630006790 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630006791 DNA binding residues [nucleotide binding] 272630006792 dimerization interface [polypeptide binding]; other site 272630006793 HAMP domain; Region: HAMP; pfam00672 272630006794 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 272630006795 ATP binding site [chemical binding]; other site 272630006796 Mg2+ binding site [ion binding]; other site 272630006797 G-X-G motif; other site 272630006798 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 272630006799 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 272630006800 Trp docking motif [polypeptide binding]; other site 272630006801 dimer interface [polypeptide binding]; other site 272630006802 active site 272630006803 small subunit binding site [polypeptide binding]; other site 272630006804 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 272630006805 catalytic triad [active] 272630006806 conserved cis-peptide bond; other site 272630006807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630006808 NAD(P) binding site [chemical binding]; other site 272630006809 active site 272630006810 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272630006811 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272630006812 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 272630006813 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272630006814 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 272630006815 Protein export membrane protein; Region: SecD_SecF; cl14618 272630006816 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 272630006817 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272630006818 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630006819 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272630006820 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272630006821 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 272630006822 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272630006823 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630006824 non-specific DNA binding site [nucleotide binding]; other site 272630006825 salt bridge; other site 272630006826 sequence-specific DNA binding site [nucleotide binding]; other site 272630006827 Cupin domain; Region: Cupin_2; pfam07883 272630006828 methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658 272630006829 Methylamine utilisation protein MauE; Region: MauE; pfam07291 272630006830 Methylamine utilization (mau) D family; mauD protein is the translation product of the mauD gene found in methylotrophic bacteria, which are able to use methylamine as a sole carbon source and a nitrogen source. mauD is an essential accessory protein for...; Region: mauD; cd02967 272630006831 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272630006832 catalytic residues [active] 272630006833 methylamine dehydrogenase (amicyanin) light chain; Region: TTQ_MADH_Lt; TIGR02659 272630006834 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 272630006835 amicyanin; Region: amicyanin; TIGR02657 272630006836 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 272630006837 MauM/NapG family ferredoxin-type protein; Region: mauM_napG; TIGR00397 272630006838 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 272630006839 4Fe-4S binding domain; Region: Fer4_5; pfam12801 272630006840 4Fe-4S binding domain; Region: Fer4_5; pfam12801 272630006841 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 272630006842 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 272630006843 dimer interface [polypeptide binding]; other site 272630006844 catalytic triad [active] 272630006845 peroxidatic and resolving cysteines [active] 272630006846 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 272630006847 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272630006848 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630006849 non-specific DNA binding site [nucleotide binding]; other site 272630006850 salt bridge; other site 272630006851 sequence-specific DNA binding site [nucleotide binding]; other site 272630006852 Protein of unknown function (DUF3768); Region: DUF3768; pfam12599 272630006853 B12 binding domain; Region: B12-binding; pfam02310 272630006854 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630006855 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272630006856 FeS/SAM binding site; other site 272630006857 Part of AAA domain; Region: AAA_19; pfam13245 272630006858 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 272630006859 Family description; Region: UvrD_C_2; pfam13538 272630006860 AAA domain; Region: AAA_23; pfam13476 272630006861 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630006862 Walker A/P-loop; other site 272630006863 ATP binding site [chemical binding]; other site 272630006864 AAA domain; Region: AAA_21; pfam13304 272630006865 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 272630006866 putative active site [active] 272630006867 putative metal-binding site [ion binding]; other site 272630006868 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 272630006869 active site 272630006870 GIY-YIG motif/motif A; other site 272630006871 catalytic site [active] 272630006872 AAA domain; Region: AAA_11; pfam13086 272630006873 Part of AAA domain; Region: AAA_19; pfam13245 272630006874 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 272630006875 AAA domain; Region: AAA_12; pfam13087 272630006876 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272630006877 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272630006878 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 272630006879 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272630006880 active site 272630006881 DNA binding site [nucleotide binding] 272630006882 Int/Topo IB signature motif; other site 272630006883 Domain of unknown function (DUF329); Region: DUF329; cl01144 272630006884 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 272630006885 active site 272630006886 dimer interface [polypeptide binding]; other site 272630006887 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 272630006888 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272630006889 N-terminal plug; other site 272630006890 ligand-binding site [chemical binding]; other site 272630006891 heme exporter protein CcmB; Region: ccmB; TIGR01190 272630006892 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 272630006893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630006894 Walker A/P-loop; other site 272630006895 ATP binding site [chemical binding]; other site 272630006896 Q-loop/lid; other site 272630006897 ABC transporter signature motif; other site 272630006898 Walker B; other site 272630006899 D-loop; other site 272630006900 H-loop/switch region; other site 272630006901 aconitate hydratase; Validated; Region: PRK09277 272630006902 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 272630006903 substrate binding site [chemical binding]; other site 272630006904 ligand binding site [chemical binding]; other site 272630006905 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 272630006906 substrate binding site [chemical binding]; other site 272630006907 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 272630006908 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 272630006909 maleylacetoacetate isomerase; Region: maiA; TIGR01262 272630006910 C-terminal domain interface [polypeptide binding]; other site 272630006911 GSH binding site (G-site) [chemical binding]; other site 272630006912 putative dimer interface [polypeptide binding]; other site 272630006913 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 272630006914 dimer interface [polypeptide binding]; other site 272630006915 N-terminal domain interface [polypeptide binding]; other site 272630006916 substrate binding pocket (H-site) [chemical binding]; other site 272630006917 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272630006918 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272630006919 EthD domain; Region: EthD; cl17553 272630006920 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272630006921 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630006922 dimer interface [polypeptide binding]; other site 272630006923 putative CheW interface [polypeptide binding]; other site 272630006924 quinolinate synthetase; Provisional; Region: PRK09375 272630006925 L-aspartate oxidase; Provisional; Region: PRK07512 272630006926 L-aspartate oxidase; Provisional; Region: PRK06175 272630006927 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272630006928 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 272630006929 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 272630006930 dimerization interface [polypeptide binding]; other site 272630006931 active site 272630006932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272630006933 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630006934 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939 272630006935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 272630006936 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 272630006937 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630006938 FeS/SAM binding site; other site 272630006939 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 272630006940 GSCFA family; Region: GSCFA; pfam08885 272630006941 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 272630006942 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272630006943 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 272630006944 IPP transferase; Region: IPPT; pfam01715 272630006945 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 272630006946 Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; Region: HAD-SF-IB; TIGR01488 272630006947 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 272630006948 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272630006949 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272630006950 protein binding site [polypeptide binding]; other site 272630006951 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272630006952 protein binding site [polypeptide binding]; other site 272630006953 HflC protein; Region: hflC; TIGR01932 272630006954 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 272630006955 HflK protein; Region: hflK; TIGR01933 272630006956 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 272630006957 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 272630006958 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272630006959 folate binding site [chemical binding]; other site 272630006960 NADP+ binding site [chemical binding]; other site 272630006961 thymidylate synthase; Reviewed; Region: thyA; PRK01827 272630006962 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 272630006963 dimerization interface [polypeptide binding]; other site 272630006964 active site 272630006965 CAAX protease self-immunity; Region: Abi; pfam02517 272630006966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 272630006967 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 272630006968 Cytochrome P450; Region: p450; cl12078 272630006969 fumarate hydratase; Reviewed; Region: fumC; PRK00485 272630006970 Class II fumarases; Region: Fumarase_classII; cd01362 272630006971 active site 272630006972 tetramer interface [polypeptide binding]; other site 272630006973 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 272630006974 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 272630006975 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 272630006976 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272630006977 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272630006978 intersubunit interface [polypeptide binding]; other site 272630006979 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272630006980 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272630006981 pyridoxamine kinase; Validated; Region: PRK05756 272630006982 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 272630006983 dimer interface [polypeptide binding]; other site 272630006984 pyridoxal binding site [chemical binding]; other site 272630006985 ATP binding site [chemical binding]; other site 272630006986 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 272630006987 NUDIX domain; Region: NUDIX; pfam00293 272630006988 nudix motif; other site 272630006989 2-isopropylmalate synthase; Validated; Region: PRK00915 272630006990 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 272630006991 active site 272630006992 catalytic residues [active] 272630006993 metal binding site [ion binding]; metal-binding site 272630006994 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 272630006995 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 272630006996 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 272630006997 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 272630006998 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 272630006999 active site 272630007000 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272630007001 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272630007002 catalytic residue [active] 272630007003 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 272630007004 HD domain; Region: HD_3; cl17350 272630007005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630007006 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272630007007 S-adenosylmethionine binding site [chemical binding]; other site 272630007008 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272630007009 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272630007010 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272630007011 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 272630007012 YcaO-like family; Region: YcaO; pfam02624 272630007013 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 272630007014 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272630007015 DNA interaction; other site 272630007016 Metal-binding active site; metal-binding site 272630007017 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630007018 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272630007019 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 272630007020 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 272630007021 putative uracil binding site [chemical binding]; other site 272630007022 putative active site [active] 272630007023 Predicted integral membrane protein [Function unknown]; Region: COG0392 272630007024 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272630007025 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 272630007026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630007027 dimer interface [polypeptide binding]; other site 272630007028 phosphorylation site [posttranslational modification] 272630007029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630007030 ATP binding site [chemical binding]; other site 272630007031 Mg2+ binding site [ion binding]; other site 272630007032 G-X-G motif; other site 272630007033 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272630007034 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272630007035 metal-binding site [ion binding] 272630007036 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272630007037 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272630007038 metal-binding site [ion binding] 272630007039 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272630007040 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272630007041 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 272630007042 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 272630007043 DNA binding residues [nucleotide binding] 272630007044 dimer interface [polypeptide binding]; other site 272630007045 copper binding site [ion binding]; other site 272630007046 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272630007047 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 272630007048 metal binding site [ion binding]; metal-binding site 272630007049 putative dimer interface [polypeptide binding]; other site 272630007050 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272630007051 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 272630007052 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 272630007053 RNA binding site [nucleotide binding]; other site 272630007054 active site 272630007055 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 272630007056 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 272630007057 translation initiation factor IF-2; Region: IF-2; TIGR00487 272630007058 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272630007059 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272630007060 G1 box; other site 272630007061 putative GEF interaction site [polypeptide binding]; other site 272630007062 GTP/Mg2+ binding site [chemical binding]; other site 272630007063 Switch I region; other site 272630007064 G2 box; other site 272630007065 G3 box; other site 272630007066 Switch II region; other site 272630007067 G4 box; other site 272630007068 G5 box; other site 272630007069 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272630007070 Translation-initiation factor 2; Region: IF-2; pfam11987 272630007071 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272630007072 hypothetical protein; Provisional; Region: PRK09190 272630007073 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 272630007074 putative RNA binding cleft [nucleotide binding]; other site 272630007075 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 272630007076 NusA N-terminal domain; Region: NusA_N; pfam08529 272630007077 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272630007078 RNA binding site [nucleotide binding]; other site 272630007079 homodimer interface [polypeptide binding]; other site 272630007080 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272630007081 G-X-X-G motif; other site 272630007082 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272630007083 G-X-X-G motif; other site 272630007084 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 272630007085 ribosome maturation protein RimP; Reviewed; Region: PRK00092 272630007086 Sm and related proteins; Region: Sm_like; cl00259 272630007087 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 272630007088 putative oligomer interface [polypeptide binding]; other site 272630007089 putative RNA binding site [nucleotide binding]; other site 272630007090 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 272630007091 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 272630007092 trimer interface [polypeptide binding]; other site 272630007093 active site 272630007094 substrate binding site [chemical binding]; other site 272630007095 CoA binding site [chemical binding]; other site 272630007096 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 272630007097 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272630007098 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272630007099 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272630007100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272630007101 Coenzyme A binding pocket [chemical binding]; other site 272630007102 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272630007103 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 272630007104 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 272630007105 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 272630007106 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272630007107 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272630007108 WHG domain; Region: WHG; pfam13305 272630007109 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 272630007110 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 272630007111 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 272630007112 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 272630007113 catalytic site [active] 272630007114 active site 272630007115 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 272630007116 putative bifunctional 4-alpha-glucanotransferase/malto-oligosyltrehalose synthase; Provisional; Region: PRK14507 272630007117 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 272630007118 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272630007119 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 272630007120 active site 272630007121 catalytic site [active] 272630007122 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272630007123 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272630007124 active site 272630007125 catalytic site [active] 272630007126 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 272630007127 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 272630007128 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272630007129 active site 272630007130 homodimer interface [polypeptide binding]; other site 272630007131 catalytic site [active] 272630007132 acceptor binding site [chemical binding]; other site 272630007133 potential frameshift: common BLAST hit: gi|218530891|ref|YP_002421707.1| trehalose synthase 272630007134 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272630007135 active site 272630007136 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272630007137 active site 272630007138 catalytic site [active] 272630007139 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 272630007140 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 272630007141 glycogen branching enzyme; Provisional; Region: PRK05402 272630007142 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 272630007143 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 272630007144 active site 272630007145 catalytic site [active] 272630007146 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 272630007147 hypothetical protein; Provisional; Region: PRK02237 272630007148 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 272630007149 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630007150 FeS/SAM binding site; other site 272630007151 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 272630007152 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272630007153 minor groove reading motif; other site 272630007154 helix-hairpin-helix signature motif; other site 272630007155 substrate binding pocket [chemical binding]; other site 272630007156 active site 272630007157 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 272630007158 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 272630007159 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272630007160 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272630007161 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 272630007162 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272630007163 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630007164 FeS/SAM binding site; other site 272630007165 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272630007166 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272630007167 active site 272630007168 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 272630007169 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 272630007170 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272630007171 P loop; other site 272630007172 GTP binding site [chemical binding]; other site 272630007173 intracellular septation protein A; Reviewed; Region: PRK00259 272630007174 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 272630007175 phytoene desaturase; Region: crtI_fam; TIGR02734 272630007176 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272630007177 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272630007178 substrate binding pocket [chemical binding]; other site 272630007179 chain length determination region; other site 272630007180 substrate-Mg2+ binding site; other site 272630007181 catalytic residues [active] 272630007182 aspartate-rich region 1; other site 272630007183 active site lid residues [active] 272630007184 aspartate-rich region 2; other site 272630007185 O-methyltransferase; Region: Methyltransf_2; pfam00891 272630007186 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 272630007187 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 272630007188 putative NAD(P) binding site [chemical binding]; other site 272630007189 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272630007190 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 272630007191 Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY). Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980 272630007192 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 272630007193 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 272630007194 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 272630007195 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 272630007196 Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290 272630007197 subunit M interface; other site 272630007198 subunit H interface; other site 272630007199 quinone binding site; other site 272630007200 bacteriopheophytin binding site; other site 272630007201 bacteriochlorophyll binding site; other site 272630007202 cytochrome C subunit interface; other site 272630007203 Fe binding site [ion binding]; other site 272630007204 Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291 272630007205 subunit H interface; other site 272630007206 subunit L interface; other site 272630007207 bacteriopheophytin binding site; other site 272630007208 carotenoid binding site; other site 272630007209 bacteriochlorophyll binding site; other site 272630007210 cytochrome C interface; other site 272630007211 quinone binding site; other site 272630007212 Fe binding site [ion binding]; other site 272630007213 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cd09224 272630007214 subunit interface [polypeptide binding]; other site 272630007215 Heme binding sites [chemical binding]; other site 272630007216 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 272630007217 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272630007218 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 272630007219 Walker A/P-loop; other site 272630007220 ATP binding site [chemical binding]; other site 272630007221 Q-loop/lid; other site 272630007222 ABC transporter signature motif; other site 272630007223 Walker B; other site 272630007224 D-loop; other site 272630007225 H-loop/switch region; other site 272630007226 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272630007227 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272630007228 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630007229 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 272630007230 TPR repeat; Region: TPR_11; pfam13414 272630007231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272630007232 binding surface 272630007233 TPR motif; other site 272630007234 TPR repeat; Region: TPR_11; pfam13414 272630007235 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272630007236 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 272630007237 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 272630007238 catalytic site [active] 272630007239 pyruvate kinase; Provisional; Region: PRK06247 272630007240 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 272630007241 domain interfaces; other site 272630007242 active site 272630007243 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 272630007244 Protein of unknown function (DUF1036); Region: DUF1036; pfam06282 272630007245 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 272630007246 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 272630007247 MOFRL family; Region: MOFRL; pfam05161 272630007248 N-formylglutamate amidohydrolase; Region: FGase; cl01522 272630007249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 272630007250 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 272630007251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 272630007252 Peptidase M15; Region: Peptidase_M15_3; cl01194 272630007253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 272630007254 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630007255 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630007256 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272630007257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630007258 active site 272630007259 phosphorylation site [posttranslational modification] 272630007260 intermolecular recognition site; other site 272630007261 dimerization interface [polypeptide binding]; other site 272630007262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630007263 Walker A motif; other site 272630007264 ATP binding site [chemical binding]; other site 272630007265 Walker B motif; other site 272630007266 arginine finger; other site 272630007267 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272630007268 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 272630007269 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 272630007270 active site 272630007271 Zn binding site [ion binding]; other site 272630007272 putative addiction module antidote; Region: doc_partner; TIGR02609 272630007273 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 272630007274 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 272630007275 ABC1 family; Region: ABC1; cl17513 272630007276 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 272630007277 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 272630007278 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 272630007279 ligand binding site [chemical binding]; other site 272630007280 homodimer interface [polypeptide binding]; other site 272630007281 NAD(P) binding site [chemical binding]; other site 272630007282 trimer interface B [polypeptide binding]; other site 272630007283 trimer interface A [polypeptide binding]; other site 272630007284 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 272630007285 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 272630007286 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 272630007287 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 272630007288 DHH family; Region: DHH; pfam01368 272630007289 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272630007290 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272630007291 ligand binding site [chemical binding]; other site 272630007292 flexible hinge region; other site 272630007293 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272630007294 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630007295 HWE histidine kinase; Region: HWE_HK; smart00911 272630007296 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 272630007297 Surface antigen; Region: Bac_surface_Ag; pfam01103 272630007298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 272630007299 Family of unknown function (DUF490); Region: DUF490; pfam04357 272630007300 cyanate hydratase; Validated; Region: PRK02866 272630007301 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 272630007302 oligomer interface [polypeptide binding]; other site 272630007303 active site 272630007304 PAS domain S-box; Region: sensory_box; TIGR00229 272630007305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630007306 putative active site [active] 272630007307 heme pocket [chemical binding]; other site 272630007308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630007309 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272630007310 Walker A motif; other site 272630007311 ATP binding site [chemical binding]; other site 272630007312 Walker B motif; other site 272630007313 arginine finger; other site 272630007314 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272630007315 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 272630007316 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 272630007317 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 272630007318 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272630007319 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630007320 dimerization interface [polypeptide binding]; other site 272630007321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630007322 PAS fold; Region: PAS_7; pfam12860 272630007323 putative active site [active] 272630007324 heme pocket [chemical binding]; other site 272630007325 PAS domain; Region: PAS; smart00091 272630007326 PAS fold; Region: PAS_7; pfam12860 272630007327 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630007328 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630007329 metal binding site [ion binding]; metal-binding site 272630007330 active site 272630007331 I-site; other site 272630007332 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630007333 Domain of unknown function (DUF892); Region: DUF892; pfam05974 272630007334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272630007335 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 272630007336 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272630007337 Cl- selectivity filter; other site 272630007338 Cl- binding residues [ion binding]; other site 272630007339 pore gating glutamate residue; other site 272630007340 dimer interface [polypeptide binding]; other site 272630007341 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272630007342 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 272630007343 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 272630007344 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 272630007345 enolase; Provisional; Region: eno; PRK00077 272630007346 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272630007347 dimer interface [polypeptide binding]; other site 272630007348 metal binding site [ion binding]; metal-binding site 272630007349 substrate binding pocket [chemical binding]; other site 272630007350 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 272630007351 Septum formation initiator; Region: DivIC; cl17659 272630007352 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 272630007353 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272630007354 tetramer interface [polypeptide binding]; other site 272630007355 TPP-binding site [chemical binding]; other site 272630007356 heterodimer interface [polypeptide binding]; other site 272630007357 phosphorylation loop region [posttranslational modification] 272630007358 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 272630007359 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272630007360 E3 interaction surface; other site 272630007361 lipoyl attachment site [posttranslational modification]; other site 272630007362 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272630007363 alpha subunit interface [polypeptide binding]; other site 272630007364 TPP binding site [chemical binding]; other site 272630007365 heterodimer interface [polypeptide binding]; other site 272630007366 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272630007367 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272630007368 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 272630007369 E3 interaction surface; other site 272630007370 lipoyl attachment site [posttranslational modification]; other site 272630007371 e3 binding domain; Region: E3_binding; pfam02817 272630007372 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272630007373 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 272630007374 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 272630007375 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272630007376 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272630007377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272630007378 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630007379 potential frameshift: common BLAST hit: gi|163852215|ref|YP_001640258.1| L-sorbosone dehydrogenase 272630007380 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 272630007381 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 272630007382 lipoyl synthase; Provisional; Region: PRK05481 272630007383 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630007384 FeS/SAM binding site; other site 272630007385 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 272630007386 putative coenzyme Q binding site [chemical binding]; other site 272630007387 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272630007388 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 272630007389 putative DNA binding site [nucleotide binding]; other site 272630007390 putative Zn2+ binding site [ion binding]; other site 272630007391 AsnC family; Region: AsnC_trans_reg; pfam01037 272630007392 ornithine cyclodeaminase; Validated; Region: PRK07589 272630007393 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 272630007394 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 272630007395 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272630007396 dimer interface [polypeptide binding]; other site 272630007397 active site 272630007398 CoA binding pocket [chemical binding]; other site 272630007399 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 272630007400 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 272630007401 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272630007402 dimer interface [polypeptide binding]; other site 272630007403 active site 272630007404 CoA binding pocket [chemical binding]; other site 272630007405 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 272630007406 classical (c) SDRs; Region: SDR_c; cd05233 272630007407 NAD(P) binding site [chemical binding]; other site 272630007408 active site 272630007409 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 272630007410 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 272630007411 iron-sulfur cluster [ion binding]; other site 272630007412 [2Fe-2S] cluster binding site [ion binding]; other site 272630007413 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 272630007414 alpha subunit interface [polypeptide binding]; other site 272630007415 active site 272630007416 substrate binding site [chemical binding]; other site 272630007417 Fe binding site [ion binding]; other site 272630007418 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 272630007419 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 272630007420 putative trimer interface [polypeptide binding]; other site 272630007421 putative CoA binding site [chemical binding]; other site 272630007422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272630007423 binding surface 272630007424 TPR motif; other site 272630007425 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 272630007426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272630007427 binding surface 272630007428 TPR motif; other site 272630007429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272630007430 TPR motif; other site 272630007431 binding surface 272630007432 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272630007433 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 272630007434 active site 272630007435 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272630007436 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 272630007437 Walker A/P-loop; other site 272630007438 ATP binding site [chemical binding]; other site 272630007439 Q-loop/lid; other site 272630007440 ABC transporter signature motif; other site 272630007441 Walker B; other site 272630007442 D-loop; other site 272630007443 H-loop/switch region; other site 272630007444 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 272630007445 active site 272630007446 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 272630007447 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 272630007448 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 272630007449 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 272630007450 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 272630007451 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 272630007452 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 272630007453 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272630007454 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 272630007455 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 272630007456 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 272630007457 substrate binding site; other site 272630007458 dimer interface; other site 272630007459 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 272630007460 homotrimer interaction site [polypeptide binding]; other site 272630007461 zinc binding site [ion binding]; other site 272630007462 CDP-binding sites; other site 272630007463 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 272630007464 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272630007465 FMN binding site [chemical binding]; other site 272630007466 active site 272630007467 catalytic residues [active] 272630007468 substrate binding site [chemical binding]; other site 272630007469 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272630007470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630007471 dimer interface [polypeptide binding]; other site 272630007472 phosphorylation site [posttranslational modification] 272630007473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630007474 ATP binding site [chemical binding]; other site 272630007475 Mg2+ binding site [ion binding]; other site 272630007476 G-X-G motif; other site 272630007477 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 272630007478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630007479 active site 272630007480 phosphorylation site [posttranslational modification] 272630007481 intermolecular recognition site; other site 272630007482 dimerization interface [polypeptide binding]; other site 272630007483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630007484 Walker A motif; other site 272630007485 ATP binding site [chemical binding]; other site 272630007486 Walker B motif; other site 272630007487 arginine finger; other site 272630007488 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 272630007489 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630007490 nucleotide binding region [chemical binding]; other site 272630007491 ATP-binding site [chemical binding]; other site 272630007492 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 272630007493 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630007494 dimerization interface [polypeptide binding]; other site 272630007495 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630007496 putative active site [active] 272630007497 heme pocket [chemical binding]; other site 272630007498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630007499 dimer interface [polypeptide binding]; other site 272630007500 phosphorylation site [posttranslational modification] 272630007501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630007502 ATP binding site [chemical binding]; other site 272630007503 Mg2+ binding site [ion binding]; other site 272630007504 G-X-G motif; other site 272630007505 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272630007506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630007507 active site 272630007508 phosphorylation site [posttranslational modification] 272630007509 intermolecular recognition site; other site 272630007510 dimerization interface [polypeptide binding]; other site 272630007511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630007512 Walker A motif; other site 272630007513 ATP binding site [chemical binding]; other site 272630007514 Walker B motif; other site 272630007515 arginine finger; other site 272630007516 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272630007517 bacterial Hfq-like; Region: Hfq; cd01716 272630007518 hexamer interface [polypeptide binding]; other site 272630007519 Sm1 motif; other site 272630007520 RNA binding site [nucleotide binding]; other site 272630007521 Sm2 motif; other site 272630007522 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 272630007523 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 272630007524 HflX GTPase family; Region: HflX; cd01878 272630007525 G1 box; other site 272630007526 GTP/Mg2+ binding site [chemical binding]; other site 272630007527 Switch I region; other site 272630007528 G2 box; other site 272630007529 G3 box; other site 272630007530 Switch II region; other site 272630007531 G4 box; other site 272630007532 G5 box; other site 272630007533 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272630007534 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272630007535 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272630007536 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 272630007537 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 272630007538 active site clefts [active] 272630007539 zinc binding site [ion binding]; other site 272630007540 dimer interface [polypeptide binding]; other site 272630007541 Domain of unknown function (DUF305); Region: DUF305; cl17794 272630007542 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 272630007543 Protein export membrane protein; Region: SecD_SecF; cl14618 272630007544 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 272630007545 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630007546 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 272630007547 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 272630007548 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 272630007549 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 272630007550 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 272630007551 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630007552 dimerization interface [polypeptide binding]; other site 272630007553 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272630007554 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630007555 dimer interface [polypeptide binding]; other site 272630007556 putative CheW interface [polypeptide binding]; other site 272630007557 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272630007558 putative binding surface; other site 272630007559 active site 272630007560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630007561 ATP binding site [chemical binding]; other site 272630007562 Mg2+ binding site [ion binding]; other site 272630007563 G-X-G motif; other site 272630007564 CheW-like domain; Region: CheW; pfam01584 272630007565 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630007566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630007567 active site 272630007568 phosphorylation site [posttranslational modification] 272630007569 intermolecular recognition site; other site 272630007570 dimerization interface [polypeptide binding]; other site 272630007571 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 272630007572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630007573 active site 272630007574 phosphorylation site [posttranslational modification] 272630007575 intermolecular recognition site; other site 272630007576 dimerization interface [polypeptide binding]; other site 272630007577 CheB methylesterase; Region: CheB_methylest; pfam01339 272630007578 Response regulator receiver domain; Region: Response_reg; pfam00072 272630007579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630007580 active site 272630007581 phosphorylation site [posttranslational modification] 272630007582 intermolecular recognition site; other site 272630007583 dimerization interface [polypeptide binding]; other site 272630007584 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630007585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630007586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630007587 dimer interface [polypeptide binding]; other site 272630007588 phosphorylation site [posttranslational modification] 272630007589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630007590 ATP binding site [chemical binding]; other site 272630007591 Mg2+ binding site [ion binding]; other site 272630007592 G-X-G motif; other site 272630007593 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630007594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630007595 active site 272630007596 phosphorylation site [posttranslational modification] 272630007597 intermolecular recognition site; other site 272630007598 dimerization interface [polypeptide binding]; other site 272630007599 PAS fold; Region: PAS_4; pfam08448 272630007600 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630007601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630007602 dimer interface [polypeptide binding]; other site 272630007603 phosphorylation site [posttranslational modification] 272630007604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630007605 ATP binding site [chemical binding]; other site 272630007606 Mg2+ binding site [ion binding]; other site 272630007607 G-X-G motif; other site 272630007608 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630007609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630007610 active site 272630007611 phosphorylation site [posttranslational modification] 272630007612 intermolecular recognition site; other site 272630007613 dimerization interface [polypeptide binding]; other site 272630007614 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 272630007615 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272630007616 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272630007617 structural tetrad; other site 272630007618 Cytochrome c; Region: Cytochrom_C; cl11414 272630007619 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 272630007620 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 272630007621 MPT binding site; other site 272630007622 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 272630007623 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 272630007624 dimer interface [polypeptide binding]; other site 272630007625 putative functional site; other site 272630007626 putative MPT binding site; other site 272630007627 PBP superfamily domain; Region: PBP_like; pfam12727 272630007628 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 272630007629 Walker A motif; other site 272630007630 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 272630007631 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 272630007632 dimer interface [polypeptide binding]; other site 272630007633 putative functional site; other site 272630007634 putative MPT binding site; other site 272630007635 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 272630007636 PBP superfamily domain; Region: PBP_like; pfam12727 272630007637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272630007638 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 272630007639 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272630007640 Walker A/P-loop; other site 272630007641 ATP binding site [chemical binding]; other site 272630007642 Q-loop/lid; other site 272630007643 ABC transporter signature motif; other site 272630007644 Walker B; other site 272630007645 D-loop; other site 272630007646 H-loop/switch region; other site 272630007647 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 272630007648 PBP superfamily domain; Region: PBP_like_2; pfam12849 272630007649 PRC-barrel domain; Region: PRC; pfam05239 272630007650 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 272630007651 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 272630007652 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 272630007653 Ligand binding site; other site 272630007654 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 272630007655 DXD motif; other site 272630007656 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 272630007657 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272630007658 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272630007659 catalytic residue [active] 272630007660 TspO/MBR family; Region: TspO_MBR; pfam03073 272630007661 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630007662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630007663 active site 272630007664 phosphorylation site [posttranslational modification] 272630007665 intermolecular recognition site; other site 272630007666 dimerization interface [polypeptide binding]; other site 272630007667 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 272630007668 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272630007669 active site 272630007670 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 272630007671 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 272630007672 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 272630007673 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 272630007674 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 272630007675 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272630007676 Walker A/P-loop; other site 272630007677 ATP binding site [chemical binding]; other site 272630007678 Q-loop/lid; other site 272630007679 ABC transporter signature motif; other site 272630007680 Walker B; other site 272630007681 D-loop; other site 272630007682 H-loop/switch region; other site 272630007683 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 272630007684 Uncharacterized conserved protein [Function unknown]; Region: COG1434 272630007685 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272630007686 putative active site [active] 272630007687 Response regulator receiver domain; Region: Response_reg; pfam00072 272630007688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630007689 active site 272630007690 phosphorylation site [posttranslational modification] 272630007691 intermolecular recognition site; other site 272630007692 dimerization interface [polypeptide binding]; other site 272630007693 gamma-glutamyl kinase; Provisional; Region: PRK05429 272630007694 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 272630007695 nucleotide binding site [chemical binding]; other site 272630007696 homotetrameric interface [polypeptide binding]; other site 272630007697 putative phosphate binding site [ion binding]; other site 272630007698 putative allosteric binding site; other site 272630007699 PUA domain; Region: PUA; pfam01472 272630007700 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 272630007701 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 272630007702 putative catalytic cysteine [active] 272630007703 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272630007704 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 272630007705 active site 272630007706 (T/H)XGH motif; other site 272630007707 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 272630007708 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 272630007709 Predicted transcriptional regulators [Transcription]; Region: COG1510 272630007710 MarR family; Region: MarR_2; pfam12802 272630007711 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 272630007712 active site 272630007713 catalytic residues [active] 272630007714 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272630007715 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272630007716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630007717 Walker A/P-loop; other site 272630007718 ATP binding site [chemical binding]; other site 272630007719 Q-loop/lid; other site 272630007720 ABC transporter signature motif; other site 272630007721 Walker B; other site 272630007722 D-loop; other site 272630007723 H-loop/switch region; other site 272630007724 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272630007725 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 272630007726 metal binding site [ion binding]; metal-binding site 272630007727 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 272630007728 MoaE interaction surface [polypeptide binding]; other site 272630007729 MoeB interaction surface [polypeptide binding]; other site 272630007730 thiocarboxylated glycine; other site 272630007731 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272630007732 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272630007733 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272630007734 GIY-YIG motif/motif A; other site 272630007735 active site 272630007736 catalytic site [active] 272630007737 putative DNA binding site [nucleotide binding]; other site 272630007738 metal binding site [ion binding]; metal-binding site 272630007739 UvrB/uvrC motif; Region: UVR; pfam02151 272630007740 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272630007741 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 272630007742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272630007743 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630007744 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 272630007745 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 272630007746 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 272630007747 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 272630007748 Uncharacterized conserved protein [Function unknown]; Region: COG1565 272630007749 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 272630007750 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 272630007751 MgtC family; Region: MgtC; pfam02308 272630007752 phosphoglucomutase; Region: PLN02307 272630007753 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 272630007754 active site 272630007755 substrate binding site [chemical binding]; other site 272630007756 metal binding site [ion binding]; metal-binding site 272630007757 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 272630007758 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 272630007759 pyruvate phosphate dikinase; Provisional; Region: PRK09279 272630007760 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 272630007761 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272630007762 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272630007763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272630007764 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630007765 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 272630007766 dimer interface [polypeptide binding]; other site 272630007767 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272630007768 metal binding site [ion binding]; metal-binding site 272630007769 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272630007770 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272630007771 ligand binding site [chemical binding]; other site 272630007772 flexible hinge region; other site 272630007773 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272630007774 MarR family; Region: MarR; pfam01047 272630007775 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 272630007776 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272630007777 RMQ12794 Microarray probe; Evidence 7 : Gene remnant 272630007778 RMQ12793 Microarray probe; Evidence 7 : Gene remnant 272630007779 two-component response regulator; Provisional; Region: PRK09191 272630007780 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 272630007781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630007782 active site 272630007783 phosphorylation site [posttranslational modification] 272630007784 intermolecular recognition site; other site 272630007785 dimerization interface [polypeptide binding]; other site 272630007786 RMQ08196 Microaray probe; Evidence 7 : Gene remnant 272630007787 RMQ08197 Microarray probe; Evidence 7 : Gene remnant 272630007788 RMQ08196 Microarray probe; Evidence 7 : Gene remnant 272630007789 aminotransferase; Provisional; Region: PRK06105 272630007790 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272630007791 inhibitor-cofactor binding pocket; inhibition site 272630007792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630007793 catalytic residue [active] 272630007794 phosphodiesterase YaeI; Provisional; Region: PRK11340 272630007795 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 272630007796 putative active site [active] 272630007797 putative metal binding site [ion binding]; other site 272630007798 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272630007799 AlkA N-terminal domain; Region: AlkA_N; pfam06029 272630007800 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 272630007801 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272630007802 minor groove reading motif; other site 272630007803 helix-hairpin-helix signature motif; other site 272630007804 substrate binding pocket [chemical binding]; other site 272630007805 active site 272630007806 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 272630007807 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 272630007808 catalytic site [active] 272630007809 putative active site [active] 272630007810 putative substrate binding site [chemical binding]; other site 272630007811 HRDC domain; Region: HRDC; pfam00570 272630007812 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272630007813 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 272630007814 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 272630007815 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272630007816 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 272630007817 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 272630007818 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 272630007819 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 272630007820 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272630007821 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272630007822 N-terminal plug; other site 272630007823 ligand-binding site [chemical binding]; other site 272630007824 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 272630007825 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272630007826 Walker A/P-loop; other site 272630007827 ATP binding site [chemical binding]; other site 272630007828 Q-loop/lid; other site 272630007829 ABC transporter signature motif; other site 272630007830 Walker B; other site 272630007831 D-loop; other site 272630007832 H-loop/switch region; other site 272630007833 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 272630007834 FecCD transport family; Region: FecCD; pfam01032 272630007835 ABC-ATPase subunit interface; other site 272630007836 dimer interface [polypeptide binding]; other site 272630007837 putative PBP binding regions; other site 272630007838 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272630007839 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272630007840 intersubunit interface [polypeptide binding]; other site 272630007841 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 272630007842 putative active site [active] 272630007843 GMP synthase; Reviewed; Region: guaA; PRK00074 272630007844 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 272630007845 AMP/PPi binding site [chemical binding]; other site 272630007846 candidate oxyanion hole; other site 272630007847 catalytic triad [active] 272630007848 potential glutamine specificity residues [chemical binding]; other site 272630007849 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 272630007850 ATP Binding subdomain [chemical binding]; other site 272630007851 Ligand Binding sites [chemical binding]; other site 272630007852 Dimerization subdomain; other site 272630007853 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 272630007854 active site 272630007855 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 272630007856 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272630007857 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 272630007858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630007859 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 272630007860 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272630007861 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 272630007862 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 272630007863 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272630007864 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 272630007865 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272630007866 active site 272630007867 cell division protein FtsW; Region: ftsW; TIGR02614 272630007868 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 272630007869 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 272630007870 active site 272630007871 homodimer interface [polypeptide binding]; other site 272630007872 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 272630007873 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272630007874 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272630007875 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272630007876 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 272630007877 putative active site [active] 272630007878 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 272630007879 FAD binding domain; Region: FAD_binding_4; pfam01565 272630007880 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 272630007881 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 272630007882 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 272630007883 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272630007884 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 272630007885 Cell division protein FtsQ; Region: FtsQ; pfam03799 272630007886 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 272630007887 Cell division protein FtsA; Region: FtsA; smart00842 272630007888 Cell division protein FtsA; Region: FtsA; pfam14450 272630007889 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 272630007890 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272630007891 nucleotide binding site [chemical binding]; other site 272630007892 SulA interaction site; other site 272630007893 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 272630007894 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 272630007895 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 272630007896 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 272630007897 active site 272630007898 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 272630007899 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 272630007900 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272630007901 Walker A/P-loop; other site 272630007902 ATP binding site [chemical binding]; other site 272630007903 Q-loop/lid; other site 272630007904 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272630007905 ABC transporter signature motif; other site 272630007906 Walker B; other site 272630007907 D-loop; other site 272630007908 H-loop/switch region; other site 272630007909 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 272630007910 yiaA/B two helix domain; Region: YiaAB; cl01759 272630007911 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 272630007912 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 272630007913 putative molybdopterin cofactor binding site [chemical binding]; other site 272630007914 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 272630007915 putative molybdopterin cofactor binding site; other site 272630007916 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272630007917 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 272630007918 nucleotide binding site [chemical binding]; other site 272630007919 NEF interaction site [polypeptide binding]; other site 272630007920 SBD interface [polypeptide binding]; other site 272630007921 chaperone protein DnaJ; Provisional; Region: PRK10767 272630007922 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272630007923 HSP70 interaction site [polypeptide binding]; other site 272630007924 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 272630007925 substrate binding site [polypeptide binding]; other site 272630007926 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272630007927 Zn binding sites [ion binding]; other site 272630007928 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272630007929 dimer interface [polypeptide binding]; other site 272630007930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630007931 S-adenosylmethionine binding site [chemical binding]; other site 272630007932 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 272630007933 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272630007934 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272630007935 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272630007936 intersubunit interface [polypeptide binding]; other site 272630007937 active site 272630007938 catalytic residue [active] 272630007939 purine nucleoside phosphorylase; Provisional; Region: PRK08202 272630007940 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 272630007941 active site 272630007942 catalytic motif [active] 272630007943 Zn binding site [ion binding]; other site 272630007944 Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; pfam09866 272630007945 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 272630007946 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 272630007947 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 272630007948 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 272630007949 putative acyl-acceptor binding pocket; other site 272630007950 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272630007951 active site 272630007952 metal binding site [ion binding]; metal-binding site 272630007953 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272630007954 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 272630007955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630007956 active site 272630007957 phosphorylation site [posttranslational modification] 272630007958 intermolecular recognition site; other site 272630007959 dimerization interface [polypeptide binding]; other site 272630007960 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272630007961 DNA-binding site [nucleotide binding]; DNA binding site 272630007962 RNA-binding motif; other site 272630007963 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272630007964 DNA-binding site [nucleotide binding]; DNA binding site 272630007965 RNA-binding motif; other site 272630007966 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 272630007967 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 272630007968 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272630007969 interface (dimer of trimers) [polypeptide binding]; other site 272630007970 Substrate-binding/catalytic site; other site 272630007971 Zn-binding sites [ion binding]; other site 272630007972 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272630007973 TPR motif; other site 272630007974 binding surface 272630007975 TPR repeat; Region: TPR_11; pfam13414 272630007976 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272630007977 binding surface 272630007978 TPR motif; other site 272630007979 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 272630007980 Predicted permeases [General function prediction only]; Region: COG0679 272630007981 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 272630007982 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272630007983 active site 272630007984 nucleotide binding site [chemical binding]; other site 272630007985 HIGH motif; other site 272630007986 KMSKS motif; other site 272630007987 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 272630007988 peptide chain release factor 2; Provisional; Region: PRK07342 272630007989 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272630007990 RF-1 domain; Region: RF-1; pfam00472 272630007991 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272630007992 Peptidase family M23; Region: Peptidase_M23; pfam01551 272630007993 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 272630007994 catalytic triad [active] 272630007995 Protein of unknown function; Region: DUF3971; pfam13116 272630007996 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272630007997 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 272630007998 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 272630007999 putative di-iron ligands [ion binding]; other site 272630008000 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 272630008001 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272630008002 active site 272630008003 HIGH motif; other site 272630008004 dimer interface [polypeptide binding]; other site 272630008005 KMSKS motif; other site 272630008006 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272630008007 RNA binding surface [nucleotide binding]; other site 272630008008 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 272630008009 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 272630008010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630008011 sequence-specific DNA binding site [nucleotide binding]; other site 272630008012 salt bridge; other site 272630008013 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 272630008014 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 272630008015 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 272630008016 Tetramer interface [polypeptide binding]; other site 272630008017 active site 272630008018 FMN-binding site [chemical binding]; other site 272630008019 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 272630008020 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 272630008021 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 272630008022 dimerization interface [polypeptide binding]; other site 272630008023 active site 272630008024 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 272630008025 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 272630008026 putative active site [active] 272630008027 Zn binding site [ion binding]; other site 272630008028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272630008029 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630008030 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 272630008031 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272630008032 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272630008033 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272630008034 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272630008035 carboxyltransferase (CT) interaction site; other site 272630008036 biotinylation site [posttranslational modification]; other site 272630008037 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 272630008038 putative active site pocket [active] 272630008039 dimerization interface [polypeptide binding]; other site 272630008040 putative catalytic residue [active] 272630008041 Acylphosphatase; Region: Acylphosphatase; pfam00708 272630008042 Protein of unknown function, DUF599; Region: DUF599; pfam04654 272630008043 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 272630008044 Uncharacterized conserved protein [Function unknown]; Region: COG1434 272630008045 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272630008046 putative active site [active] 272630008047 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272630008048 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 272630008049 putative C-terminal domain interface [polypeptide binding]; other site 272630008050 putative GSH binding site (G-site) [chemical binding]; other site 272630008051 putative dimer interface [polypeptide binding]; other site 272630008052 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 272630008053 N-terminal domain interface [polypeptide binding]; other site 272630008054 dimer interface [polypeptide binding]; other site 272630008055 substrate binding pocket (H-site) [chemical binding]; other site 272630008056 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272630008057 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630008058 FeS/SAM binding site; other site 272630008059 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 272630008060 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272630008061 motif 1; other site 272630008062 dimer interface [polypeptide binding]; other site 272630008063 active site 272630008064 motif 2; other site 272630008065 motif 3; other site 272630008066 elongation factor P; Validated; Region: PRK00529 272630008067 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272630008068 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272630008069 RNA binding site [nucleotide binding]; other site 272630008070 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272630008071 RNA binding site [nucleotide binding]; other site 272630008072 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 272630008073 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272630008074 DNA-binding site [nucleotide binding]; DNA binding site 272630008075 RNA-binding motif; other site 272630008076 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272630008077 DNA-binding site [nucleotide binding]; DNA binding site 272630008078 RNA-binding motif; other site 272630008079 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 272630008080 magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406 272630008081 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272630008082 metal ion-dependent adhesion site (MIDAS); other site 272630008083 putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056 272630008084 phytoene desaturase; Region: crtI_fam; TIGR02734 272630008085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272630008086 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 272630008087 active site lid residues [active] 272630008088 substrate binding pocket [chemical binding]; other site 272630008089 catalytic residues [active] 272630008090 substrate-Mg2+ binding site; other site 272630008091 aspartate-rich region 1; other site 272630008092 aspartate-rich region 2; other site 272630008093 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272630008094 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 272630008095 UreF; Region: UreF; pfam01730 272630008096 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 272630008097 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 272630008098 dimer interface [polypeptide binding]; other site 272630008099 catalytic residues [active] 272630008100 urease subunit alpha; Reviewed; Region: ureC; PRK13207 272630008101 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 272630008102 subunit interactions [polypeptide binding]; other site 272630008103 active site 272630008104 flap region; other site 272630008105 Predicted membrane protein [Function unknown]; Region: COG4420 272630008106 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272630008107 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272630008108 Zn2+ binding site [ion binding]; other site 272630008109 Mg2+ binding site [ion binding]; other site 272630008110 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 272630008111 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 272630008112 alpha-gamma subunit interface [polypeptide binding]; other site 272630008113 beta-gamma subunit interface [polypeptide binding]; other site 272630008114 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 272630008115 alpha-beta subunit interface [polypeptide binding]; other site 272630008116 UreD urease accessory protein; Region: UreD; pfam01774 272630008117 Flavin Reductases; Region: FlaRed; cl00801 272630008118 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 272630008119 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 272630008120 active site 272630008121 putative substrate binding pocket [chemical binding]; other site 272630008122 GcrA cell cycle regulator; Region: GcrA; cl11564 272630008123 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272630008124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630008125 NAD(P) binding site [chemical binding]; other site 272630008126 active site 272630008127 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 272630008128 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272630008129 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 272630008130 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 272630008131 threonine dehydratase; Reviewed; Region: PRK09224 272630008132 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 272630008133 tetramer interface [polypeptide binding]; other site 272630008134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630008135 catalytic residue [active] 272630008136 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 272630008137 putative Ile/Val binding site [chemical binding]; other site 272630008138 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 272630008139 putative Ile/Val binding site [chemical binding]; other site 272630008140 PilZ domain; Region: PilZ; pfam07238 272630008141 SlyX; Region: SlyX; pfam04102 272630008142 Porin subfamily; Region: Porin_2; pfam02530 272630008143 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 272630008144 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 272630008145 Class II flagellar assembly regulator; Region: FliX; pfam10768 272630008146 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 272630008147 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 272630008148 Rod binding protein; Region: Rod-binding; cl01626 272630008149 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 272630008150 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 272630008151 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 272630008152 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786 272630008153 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 272630008154 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 272630008155 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272630008156 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272630008157 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 272630008158 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272630008159 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 272630008160 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK12785 272630008161 flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795 272630008162 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 272630008163 Uncharacterized conserved protein [Function unknown]; Region: COG3334 272630008164 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 272630008165 catalytic residues [active] 272630008166 dimer interface [polypeptide binding]; other site 272630008167 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 272630008168 Transglycosylase SLT domain; Region: SLT_2; pfam13406 272630008169 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272630008170 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272630008171 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272630008172 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 272630008173 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 272630008174 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272630008175 Uncharacterized conserved protein [Function unknown]; Region: COG3791 272630008176 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 272630008177 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272630008178 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 272630008179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630008180 dimer interface [polypeptide binding]; other site 272630008181 phosphorylation site [posttranslational modification] 272630008182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630008183 ATP binding site [chemical binding]; other site 272630008184 Mg2+ binding site [ion binding]; other site 272630008185 G-X-G motif; other site 272630008186 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272630008187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630008188 active site 272630008189 phosphorylation site [posttranslational modification] 272630008190 intermolecular recognition site; other site 272630008191 dimerization interface [polypeptide binding]; other site 272630008192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630008193 ATP binding site [chemical binding]; other site 272630008194 Walker A motif; other site 272630008195 Walker B motif; other site 272630008196 arginine finger; other site 272630008197 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272630008198 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630008199 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630008200 metal binding site [ion binding]; metal-binding site 272630008201 active site 272630008202 I-site; other site 272630008203 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272630008204 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272630008205 GatB domain; Region: GatB_Yqey; smart00845 272630008206 Cation efflux family; Region: Cation_efflux; pfam01545 272630008207 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272630008208 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 272630008209 FAD binding domain; Region: FAD_binding_3; pfam01494 272630008210 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272630008211 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 272630008212 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 272630008213 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 272630008214 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 272630008215 Leucine rich repeat; Region: LRR_8; pfam13855 272630008216 Leucine rich repeat; Region: LRR_8; pfam13855 272630008217 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 272630008218 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272630008219 active site 272630008220 ATP binding site [chemical binding]; other site 272630008221 substrate binding site [chemical binding]; other site 272630008222 activation loop (A-loop); other site 272630008223 Uncharacterized conserved protein [Function unknown]; Region: COG3025 272630008224 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 272630008225 putative active site [active] 272630008226 putative metal binding residues [ion binding]; other site 272630008227 signature motif; other site 272630008228 putative triphosphate binding site [ion binding]; other site 272630008229 CHAD domain; Region: CHAD; pfam05235 272630008230 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 272630008231 putative active site [active] 272630008232 putative metal binding residues [ion binding]; other site 272630008233 signature motif; other site 272630008234 putative dimer interface [polypeptide binding]; other site 272630008235 putative phosphate binding site [ion binding]; other site 272630008236 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 272630008237 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630008238 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 272630008239 DNA binding residues [nucleotide binding] 272630008240 SnoaL-like domain; Region: SnoaL_2; pfam12680 272630008241 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 272630008242 Uncharacterized conserved protein [Function unknown]; Region: COG2128 272630008243 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 272630008244 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 272630008245 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272630008246 catalytic loop [active] 272630008247 iron binding site [ion binding]; other site 272630008248 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272630008249 cyclase homology domain; Region: CHD; cd07302 272630008250 nucleotidyl binding site; other site 272630008251 metal binding site [ion binding]; metal-binding site 272630008252 dimer interface [polypeptide binding]; other site 272630008253 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272630008254 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272630008255 Major royal jelly protein; Region: MRJP; pfam03022 272630008256 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 272630008257 putative heme binding pocket [chemical binding]; other site 272630008258 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 272630008259 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 272630008260 aminotransferase; Validated; Region: PRK09148 272630008261 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272630008262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630008263 homodimer interface [polypeptide binding]; other site 272630008264 catalytic residue [active] 272630008265 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 272630008266 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 272630008267 putative cation:proton antiport protein; Provisional; Region: PRK10669 272630008268 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 272630008269 TrkA-N domain; Region: TrkA_N; pfam02254 272630008270 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 272630008271 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 272630008272 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 272630008273 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 272630008274 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 272630008275 dimer interface [polypeptide binding]; other site 272630008276 motif 1; other site 272630008277 active site 272630008278 motif 2; other site 272630008279 motif 3; other site 272630008280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272630008281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272630008282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 272630008283 SnoaL-like domain; Region: SnoaL_2; pfam12680 272630008284 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 272630008285 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 272630008286 tandem repeat interface [polypeptide binding]; other site 272630008287 oligomer interface [polypeptide binding]; other site 272630008288 active site residues [active] 272630008289 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 272630008290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630008291 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 272630008292 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272630008293 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272630008294 substrate binding pocket [chemical binding]; other site 272630008295 chain length determination region; other site 272630008296 substrate-Mg2+ binding site; other site 272630008297 catalytic residues [active] 272630008298 aspartate-rich region 1; other site 272630008299 active site lid residues [active] 272630008300 aspartate-rich region 2; other site 272630008301 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 272630008302 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272630008303 Porin subfamily; Region: Porin_2; pfam02530 272630008304 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272630008305 binding surface 272630008306 TPR motif; other site 272630008307 TPR repeat; Region: TPR_11; pfam13414 272630008308 TPR repeat; Region: TPR_11; pfam13414 272630008309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272630008310 binding surface 272630008311 TPR motif; other site 272630008312 TPR repeat; Region: TPR_11; pfam13414 272630008313 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 272630008314 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 272630008315 active site 272630008316 non-prolyl cis peptide bond; other site 272630008317 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 272630008318 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272630008319 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272630008320 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272630008321 Walker A/P-loop; other site 272630008322 ATP binding site [chemical binding]; other site 272630008323 Q-loop/lid; other site 272630008324 ABC transporter signature motif; other site 272630008325 Walker B; other site 272630008326 D-loop; other site 272630008327 H-loop/switch region; other site 272630008328 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 272630008329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630008330 ATP binding site [chemical binding]; other site 272630008331 Mg2+ binding site [ion binding]; other site 272630008332 G-X-G motif; other site 272630008333 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272630008334 anchoring element; other site 272630008335 dimer interface [polypeptide binding]; other site 272630008336 ATP binding site [chemical binding]; other site 272630008337 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272630008338 active site 272630008339 metal binding site [ion binding]; metal-binding site 272630008340 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272630008341 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 272630008342 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 272630008343 tetramer interface [polypeptide binding]; other site 272630008344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630008345 catalytic residue [active] 272630008346 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272630008347 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272630008348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630008349 Walker A/P-loop; other site 272630008350 ATP binding site [chemical binding]; other site 272630008351 Q-loop/lid; other site 272630008352 ABC transporter signature motif; other site 272630008353 Walker B; other site 272630008354 D-loop; other site 272630008355 H-loop/switch region; other site 272630008356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630008357 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272630008358 putative substrate translocation pore; other site 272630008359 PRC-barrel domain; Region: PRC; pfam05239 272630008360 SWIB/MDM2 domain; Region: SWIB; pfam02201 272630008361 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272630008362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630008363 NAD(P) binding site [chemical binding]; other site 272630008364 active site 272630008365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630008366 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272630008367 putative substrate translocation pore; other site 272630008368 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272630008369 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272630008370 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 272630008371 catalytic site [active] 272630008372 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 272630008373 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272630008374 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 272630008375 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 272630008376 C-terminal domain interface [polypeptide binding]; other site 272630008377 GSH binding site (G-site) [chemical binding]; other site 272630008378 dimer interface [polypeptide binding]; other site 272630008379 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 272630008380 N-terminal domain interface [polypeptide binding]; other site 272630008381 putative dimer interface [polypeptide binding]; other site 272630008382 active site 272630008383 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 272630008384 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272630008385 nucleoside/Zn binding site; other site 272630008386 dimer interface [polypeptide binding]; other site 272630008387 catalytic motif [active] 272630008388 spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886 272630008389 Short C-terminal domain; Region: SHOCT; pfam09851 272630008390 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 272630008391 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 272630008392 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 272630008393 active site 272630008394 catalytic site [active] 272630008395 histidine kinase; Provisional; Region: PRK13557 272630008396 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630008397 putative active site [active] 272630008398 heme pocket [chemical binding]; other site 272630008399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630008400 dimer interface [polypeptide binding]; other site 272630008401 phosphorylation site [posttranslational modification] 272630008402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630008403 ATP binding site [chemical binding]; other site 272630008404 Mg2+ binding site [ion binding]; other site 272630008405 G-X-G motif; other site 272630008406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630008407 active site 272630008408 phosphorylation site [posttranslational modification] 272630008409 intermolecular recognition site; other site 272630008410 dimerization interface [polypeptide binding]; other site 272630008411 isocitrate dehydrogenase; Validated; Region: PRK08299 272630008412 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 272630008413 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 272630008414 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 272630008415 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 272630008416 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 272630008417 putative NAD(P) binding site [chemical binding]; other site 272630008418 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 272630008419 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 272630008420 dimerization interface [polypeptide binding]; other site 272630008421 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272630008422 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630008423 dimer interface [polypeptide binding]; other site 272630008424 putative CheW interface [polypeptide binding]; other site 272630008425 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630008426 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 272630008427 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272630008428 homodimer interface [polypeptide binding]; other site 272630008429 substrate-cofactor binding pocket; other site 272630008430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630008431 catalytic residue [active] 272630008432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630008433 active site 272630008434 phosphorylation site [posttranslational modification] 272630008435 intermolecular recognition site; other site 272630008436 dimerization interface [polypeptide binding]; other site 272630008437 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 272630008438 Cysteine-rich domain; Region: CCG; pfam02754 272630008439 Cysteine-rich domain; Region: CCG; pfam02754 272630008440 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 272630008441 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 272630008442 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272630008443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272630008444 ATP binding site [chemical binding]; other site 272630008445 putative Mg++ binding site [ion binding]; other site 272630008446 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630008447 nucleotide binding region [chemical binding]; other site 272630008448 ATP-binding site [chemical binding]; other site 272630008449 DEAD/H associated; Region: DEAD_assoc; pfam08494 272630008450 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272630008451 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 272630008452 putative active site [active] 272630008453 putative metal binding site [ion binding]; other site 272630008454 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 272630008455 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 272630008456 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272630008457 putative ion selectivity filter; other site 272630008458 putative pore gating glutamate residue; other site 272630008459 putative H+/Cl- coupling transport residue; other site 272630008460 short chain dehydrogenase; Provisional; Region: PRK06197 272630008461 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 272630008462 putative NAD(P) binding site [chemical binding]; other site 272630008463 active site 272630008464 thiamine monophosphate kinase; Provisional; Region: PRK05731 272630008465 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 272630008466 ATP binding site [chemical binding]; other site 272630008467 dimerization interface [polypeptide binding]; other site 272630008468 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 272630008469 putative RNA binding site [nucleotide binding]; other site 272630008470 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 272630008471 homopentamer interface [polypeptide binding]; other site 272630008472 active site 272630008473 hypothetical protein; Validated; Region: PRK08238 272630008474 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 272630008475 Predicted membrane protein [Function unknown]; Region: COG2246 272630008476 GtrA-like protein; Region: GtrA; pfam04138 272630008477 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 272630008478 Lumazine binding domain; Region: Lum_binding; pfam00677 272630008479 Lumazine binding domain; Region: Lum_binding; pfam00677 272630008480 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 272630008481 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 272630008482 catalytic motif [active] 272630008483 Zn binding site [ion binding]; other site 272630008484 RibD C-terminal domain; Region: RibD_C; cl17279 272630008485 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 272630008486 ATP cone domain; Region: ATP-cone; pfam03477 272630008487 Predicted transcriptional regulator [Transcription]; Region: COG1959 272630008488 Transcriptional regulator; Region: Rrf2; cl17282 272630008489 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 272630008490 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272630008491 dimer interface [polypeptide binding]; other site 272630008492 active site 272630008493 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272630008494 folate binding site [chemical binding]; other site 272630008495 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 272630008496 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 272630008497 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 272630008498 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 272630008499 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 272630008500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 272630008501 Thioredoxin; Region: Thioredoxin_4; pfam13462 272630008502 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 272630008503 Protein of unknown function (DUF721); Region: DUF721; cl02324 272630008504 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 272630008505 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272630008506 minor groove reading motif; other site 272630008507 helix-hairpin-helix signature motif; other site 272630008508 substrate binding pocket [chemical binding]; other site 272630008509 active site 272630008510 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 272630008511 DNA binding and oxoG recognition site [nucleotide binding] 272630008512 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 272630008513 DNA methylase; Region: N6_N4_Mtase; pfam01555 272630008514 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 272630008515 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 272630008516 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272630008517 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272630008518 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272630008519 Porin subfamily; Region: Porin_2; pfam02530 272630008520 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 272630008521 ligand binding site [chemical binding]; other site 272630008522 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272630008523 cyclase homology domain; Region: CHD; cd07302 272630008524 nucleotidyl binding site; other site 272630008525 metal binding site [ion binding]; metal-binding site 272630008526 dimer interface [polypeptide binding]; other site 272630008527 HD domain; Region: HD_3; pfam13023 272630008528 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272630008529 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272630008530 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272630008531 catalytic residue [active] 272630008532 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 272630008533 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 272630008534 dimer interface [polypeptide binding]; other site 272630008535 active site 272630008536 catalytic residue [active] 272630008537 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272630008538 SmpB-tmRNA interface; other site 272630008539 Uncharacterized conserved protein [Function unknown]; Region: COG1432 272630008540 LabA_like proteins; Region: LabA; cd10911 272630008541 putative metal binding site [ion binding]; other site 272630008542 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272630008543 active site 272630008544 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272630008545 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272630008546 Zn2+ binding site [ion binding]; other site 272630008547 Mg2+ binding site [ion binding]; other site 272630008548 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272630008549 synthetase active site [active] 272630008550 NTP binding site [chemical binding]; other site 272630008551 metal binding site [ion binding]; metal-binding site 272630008552 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 272630008553 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 272630008554 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 272630008555 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 272630008556 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 272630008557 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 272630008558 Glycoprotease family; Region: Peptidase_M22; pfam00814 272630008559 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272630008560 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272630008561 Coenzyme A binding pocket [chemical binding]; other site 272630008562 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 272630008563 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272630008564 putative acyl-acceptor binding pocket; other site 272630008565 MEKHLA domain; Region: MEKHLA; pfam08670 272630008566 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630008567 putative active site [active] 272630008568 heme pocket [chemical binding]; other site 272630008569 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 272630008570 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272630008571 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630008572 FeS/SAM binding site; other site 272630008573 TRAM domain; Region: TRAM; cl01282 272630008574 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 272630008575 PhoH-like protein; Region: PhoH; pfam02562 272630008576 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 272630008577 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 272630008578 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272630008579 Transporter associated domain; Region: CorC_HlyC; smart01091 272630008580 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 272630008581 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 272630008582 putative active site [active] 272630008583 catalytic triad [active] 272630008584 putative dimer interface [polypeptide binding]; other site 272630008585 BA14K-like protein; Region: BA14K; pfam07886 272630008586 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 272630008587 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 272630008588 tetramer interface [polypeptide binding]; other site 272630008589 heme binding pocket [chemical binding]; other site 272630008590 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 272630008591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630008592 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 272630008593 dimerization interface [polypeptide binding]; other site 272630008594 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 272630008595 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 272630008596 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 272630008597 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 272630008598 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 272630008599 putative active site [active] 272630008600 putative metal binding site [ion binding]; other site 272630008601 glutamate racemase; Provisional; Region: PRK00865 272630008602 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 272630008603 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 272630008604 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 272630008605 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 272630008606 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 272630008607 active site 272630008608 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272630008609 Protein of unknown function (DUF779); Region: DUF779; pfam05610 272630008610 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 272630008611 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 272630008612 [4Fe-4S] binding site [ion binding]; other site 272630008613 molybdopterin cofactor binding site; other site 272630008614 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 272630008615 molybdopterin cofactor binding site; other site 272630008616 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 272630008617 siroheme synthase; Provisional; Region: cysG; PRK10637 272630008618 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 272630008619 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 272630008620 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 272630008621 active site 272630008622 SAM binding site [chemical binding]; other site 272630008623 homodimer interface [polypeptide binding]; other site 272630008624 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 272630008625 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 272630008626 Cu(I) binding site [ion binding]; other site 272630008627 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 272630008628 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272630008629 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272630008630 active site 272630008631 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272630008632 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272630008633 substrate binding pocket [chemical binding]; other site 272630008634 membrane-bound complex binding site; other site 272630008635 hinge residues; other site 272630008636 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 272630008637 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 272630008638 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 272630008639 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 272630008640 metal ion-dependent adhesion site (MIDAS); other site 272630008641 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 272630008642 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 272630008643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272630008644 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272630008645 HSP70 interaction site [polypeptide binding]; other site 272630008646 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 272630008647 hypothetical protein; Provisional; Region: PRK09256 272630008648 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 272630008649 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 272630008650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630008651 S-adenosylmethionine binding site [chemical binding]; other site 272630008652 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 272630008653 ATP-dependent DNA ligase [DNA replication, recombination, and repair]; Region: CDC9; COG1793 272630008654 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 272630008655 active site 272630008656 DNA binding site [nucleotide binding] 272630008657 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 272630008658 DNA binding site [nucleotide binding] 272630008659 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 272630008660 Protein of unknown function, DUF606; Region: DUF606; pfam04657 272630008661 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 272630008662 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 272630008663 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272630008664 substrate binding site [chemical binding]; other site 272630008665 oxyanion hole (OAH) forming residues; other site 272630008666 trimer interface [polypeptide binding]; other site 272630008667 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272630008668 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272630008669 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630008670 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 272630008671 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272630008672 dimer interface [polypeptide binding]; other site 272630008673 active site 272630008674 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 272630008675 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 272630008676 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 272630008677 FAD binding site [chemical binding]; other site 272630008678 substrate binding site [chemical binding]; other site 272630008679 catalytic residues [active] 272630008680 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 272630008681 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272630008682 Sel1-like repeats; Region: SEL1; smart00671 272630008683 Sel1-like repeats; Region: SEL1; smart00671 272630008684 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 272630008685 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 272630008686 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 272630008687 active site 272630008688 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272630008689 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272630008690 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272630008691 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272630008692 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272630008693 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272630008694 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272630008695 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 272630008696 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 272630008697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630008698 catalytic residue [active] 272630008699 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 272630008700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 272630008701 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 272630008702 Subunit III/VIIa interface [polypeptide binding]; other site 272630008703 Phospholipid binding site [chemical binding]; other site 272630008704 Subunit I/III interface [polypeptide binding]; other site 272630008705 Subunit III/VIb interface [polypeptide binding]; other site 272630008706 Subunit III/VIa interface; other site 272630008707 Subunit III/Vb interface [polypeptide binding]; other site 272630008708 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; pfam04442 272630008709 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 272630008710 UbiA prenyltransferase family; Region: UbiA; pfam01040 272630008711 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 272630008712 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 272630008713 Subunit I/III interface [polypeptide binding]; other site 272630008714 D-pathway; other site 272630008715 Subunit I/VIIc interface [polypeptide binding]; other site 272630008716 Subunit I/IV interface [polypeptide binding]; other site 272630008717 Subunit I/II interface [polypeptide binding]; other site 272630008718 Low-spin heme (heme a) binding site [chemical binding]; other site 272630008719 Subunit I/VIIa interface [polypeptide binding]; other site 272630008720 Subunit I/VIa interface [polypeptide binding]; other site 272630008721 Dimer interface; other site 272630008722 Putative water exit pathway; other site 272630008723 Binuclear center (heme a3/CuB) [ion binding]; other site 272630008724 K-pathway; other site 272630008725 Subunit I/Vb interface [polypeptide binding]; other site 272630008726 Putative proton exit pathway; other site 272630008727 Subunit I/VIb interface; other site 272630008728 Subunit I/VIc interface [polypeptide binding]; other site 272630008729 Electron transfer pathway; other site 272630008730 Subunit I/VIIIb interface [polypeptide binding]; other site 272630008731 Subunit I/VIIb interface [polypeptide binding]; other site 272630008732 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 272630008733 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 272630008734 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 272630008735 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 272630008736 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 272630008737 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 272630008738 active site 272630008739 dimer interface [polypeptide binding]; other site 272630008740 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 272630008741 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 272630008742 active site 272630008743 FMN binding site [chemical binding]; other site 272630008744 substrate binding site [chemical binding]; other site 272630008745 3Fe-4S cluster binding site [ion binding]; other site 272630008746 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 272630008747 domain interface; other site 272630008748 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 272630008749 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272630008750 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 272630008751 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272630008752 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272630008753 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272630008754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630008755 active site 272630008756 phosphorylation site [posttranslational modification] 272630008757 intermolecular recognition site; other site 272630008758 dimerization interface [polypeptide binding]; other site 272630008759 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630008760 DNA binding residues [nucleotide binding] 272630008761 dimerization interface [polypeptide binding]; other site 272630008762 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 272630008763 active site 272630008764 catalytic triad [active] 272630008765 oxyanion hole [active] 272630008766 Transglycosylase SLT domain; Region: SLT_2; pfam13406 272630008767 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272630008768 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272630008769 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272630008770 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272630008771 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272630008772 NAD binding site [chemical binding]; other site 272630008773 homodimer interface [polypeptide binding]; other site 272630008774 active site 272630008775 substrate binding site [chemical binding]; other site 272630008776 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272630008777 active site 272630008778 tetramer interface; other site 272630008779 N-formylglutamate amidohydrolase; Region: FGase; cl01522 272630008780 Response regulator receiver domain; Region: Response_reg; pfam00072 272630008781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630008782 active site 272630008783 phosphorylation site [posttranslational modification] 272630008784 intermolecular recognition site; other site 272630008785 dimerization interface [polypeptide binding]; other site 272630008786 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 272630008787 GSH binding site [chemical binding]; other site 272630008788 catalytic residues [active] 272630008789 Predicted amidohydrolase [General function prediction only]; Region: COG0388 272630008790 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 272630008791 putative active site [active] 272630008792 catalytic triad [active] 272630008793 dimer interface [polypeptide binding]; other site 272630008794 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 272630008795 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630008796 PAS domain; Region: PAS_9; pfam13426 272630008797 putative active site [active] 272630008798 heme pocket [chemical binding]; other site 272630008799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630008800 Histidine kinase; Region: HisKA_2; pfam07568 272630008801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630008802 ATP binding site [chemical binding]; other site 272630008803 Mg2+ binding site [ion binding]; other site 272630008804 G-X-G motif; other site 272630008805 methionine sulfoxide reductase A; Provisional; Region: PRK00058 272630008806 hypothetical protein; Provisional; Region: PRK05208 272630008807 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630008808 non-specific DNA binding site [nucleotide binding]; other site 272630008809 salt bridge; other site 272630008810 sequence-specific DNA binding site [nucleotide binding]; other site 272630008811 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 272630008812 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 272630008813 PRC-barrel domain; Region: PRC; pfam05239 272630008814 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 272630008815 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 272630008816 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272630008817 catalytic residues [active] 272630008818 argininosuccinate lyase; Provisional; Region: PRK00855 272630008819 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 272630008820 active sites [active] 272630008821 tetramer interface [polypeptide binding]; other site 272630008822 glutamine-tRNA ligase; Region: PLN02859 272630008823 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 272630008824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272630008825 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 272630008826 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 272630008827 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 272630008828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272630008829 motif II; other site 272630008830 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 272630008831 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 272630008832 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 272630008833 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 272630008834 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272630008835 IncA protein; Region: IncA; pfam04156 272630008836 PAS domain; Region: PAS_8; pfam13188 272630008837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630008838 PAS fold; Region: PAS_3; pfam08447 272630008839 putative active site [active] 272630008840 heme pocket [chemical binding]; other site 272630008841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630008842 PAS fold; Region: PAS_3; pfam08447 272630008843 putative active site [active] 272630008844 heme pocket [chemical binding]; other site 272630008845 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630008846 HWE histidine kinase; Region: HWE_HK; pfam07536 272630008847 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272630008848 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272630008849 Probable Catalytic site; other site 272630008850 metal-binding site 272630008851 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272630008852 active site 272630008853 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 272630008854 Peptidase family M48; Region: Peptidase_M48; pfam01435 272630008855 PA26 p53-induced protein (sestrin); Region: PA26; pfam04636 272630008856 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272630008857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630008858 non-specific DNA binding site [nucleotide binding]; other site 272630008859 salt bridge; other site 272630008860 sequence-specific DNA binding site [nucleotide binding]; other site 272630008861 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272630008862 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272630008863 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272630008864 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272630008865 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 272630008866 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 272630008867 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272630008868 active site 272630008869 interdomain interaction site; other site 272630008870 putative metal-binding site [ion binding]; other site 272630008871 nucleotide binding site [chemical binding]; other site 272630008872 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272630008873 domain I; other site 272630008874 DNA binding groove [nucleotide binding] 272630008875 phosphate binding site [ion binding]; other site 272630008876 domain II; other site 272630008877 domain III; other site 272630008878 nucleotide binding site [chemical binding]; other site 272630008879 catalytic site [active] 272630008880 domain IV; other site 272630008881 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272630008882 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 272630008883 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 272630008884 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 272630008885 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 272630008886 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 272630008887 Moco binding site; other site 272630008888 metal coordination site [ion binding]; other site 272630008889 Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292 272630008890 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 272630008891 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 272630008892 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272630008893 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272630008894 dihydroorotase; Validated; Region: PRK09059 272630008895 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272630008896 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 272630008897 active site 272630008898 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 272630008899 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 272630008900 DNA protecting protein DprA; Region: dprA; TIGR00732 272630008901 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 272630008902 active site 272630008903 catalytic triad [active] 272630008904 oxyanion hole [active] 272630008905 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 272630008906 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 272630008907 conserved cys residue [active] 272630008908 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 272630008909 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 272630008910 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 272630008911 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 272630008912 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 272630008913 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 272630008914 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630008915 non-specific DNA binding site [nucleotide binding]; other site 272630008916 salt bridge; other site 272630008917 sequence-specific DNA binding site [nucleotide binding]; other site 272630008918 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 272630008919 Protein export membrane protein; Region: SecD_SecF; cl14618 272630008920 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272630008921 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272630008922 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630008923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272630008924 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630008925 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 272630008926 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272630008927 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272630008928 catalytic residue [active] 272630008929 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 272630008930 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 272630008931 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 272630008932 Usg-like family; Region: Usg; cl11567 272630008933 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 272630008934 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272630008935 ring oligomerisation interface [polypeptide binding]; other site 272630008936 ATP/Mg binding site [chemical binding]; other site 272630008937 stacking interactions; other site 272630008938 hinge regions; other site 272630008939 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272630008940 oligomerisation interface [polypeptide binding]; other site 272630008941 mobile loop; other site 272630008942 roof hairpin; other site 272630008943 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 272630008944 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272630008945 active site 272630008946 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272630008947 NMT1-like family; Region: NMT1_2; pfam13379 272630008948 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 272630008949 Moco binding site; other site 272630008950 metal coordination site [ion binding]; other site 272630008951 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272630008952 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272630008953 membrane-bound complex binding site; other site 272630008954 hinge residues; other site 272630008955 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 272630008956 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 272630008957 xanthine permease; Region: pbuX; TIGR03173 272630008958 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 272630008959 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 272630008960 putative catalytic residue [active] 272630008961 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272630008962 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272630008963 Walker A/P-loop; other site 272630008964 ATP binding site [chemical binding]; other site 272630008965 Q-loop/lid; other site 272630008966 ABC transporter signature motif; other site 272630008967 Walker B; other site 272630008968 D-loop; other site 272630008969 H-loop/switch region; other site 272630008970 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272630008971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630008972 dimer interface [polypeptide binding]; other site 272630008973 conserved gate region; other site 272630008974 putative PBP binding loops; other site 272630008975 ABC-ATPase subunit interface; other site 272630008976 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272630008977 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272630008978 substrate binding pocket [chemical binding]; other site 272630008979 membrane-bound complex binding site; other site 272630008980 NosL; Region: NosL; cl01769 272630008981 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272630008982 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 272630008983 ligand binding site [chemical binding]; other site 272630008984 flexible hinge region; other site 272630008985 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272630008986 putative switch regulator; other site 272630008987 non-specific DNA interactions [nucleotide binding]; other site 272630008988 DNA binding site [nucleotide binding] 272630008989 sequence specific DNA binding site [nucleotide binding]; other site 272630008990 putative cAMP binding site [chemical binding]; other site 272630008991 HEAT repeats; Region: HEAT_2; pfam13646 272630008992 HEAT repeats; Region: HEAT_2; pfam13646 272630008993 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 272630008994 putative oxidoreductase; Provisional; Region: PRK08275 272630008995 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 272630008996 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272630008997 Protein of unknown function (DUF971); Region: DUF971; pfam06155 272630008998 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630008999 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630009000 metal binding site [ion binding]; metal-binding site 272630009001 active site 272630009002 I-site; other site 272630009003 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630009004 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 272630009005 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272630009006 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 272630009007 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630009008 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 272630009009 putative dimerization interface [polypeptide binding]; other site 272630009010 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 272630009011 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 272630009012 hypothetical protein; Validated; Region: PRK07581 272630009013 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 272630009014 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 272630009015 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 272630009016 Walker A/P-loop; other site 272630009017 ATP binding site [chemical binding]; other site 272630009018 Q-loop/lid; other site 272630009019 ABC transporter signature motif; other site 272630009020 Walker B; other site 272630009021 D-loop; other site 272630009022 H-loop/switch region; other site 272630009023 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 272630009024 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 272630009025 Walker A/P-loop; other site 272630009026 ATP binding site [chemical binding]; other site 272630009027 Q-loop/lid; other site 272630009028 ABC transporter signature motif; other site 272630009029 Walker B; other site 272630009030 D-loop; other site 272630009031 H-loop/switch region; other site 272630009032 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 272630009033 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 272630009034 TM-ABC transporter signature motif; other site 272630009035 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272630009036 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 272630009037 TM-ABC transporter signature motif; other site 272630009038 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 272630009039 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 272630009040 putative ligand binding site [chemical binding]; other site 272630009041 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 272630009042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630009043 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630009044 dimer interface [polypeptide binding]; other site 272630009045 phosphorylation site [posttranslational modification] 272630009046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630009047 ATP binding site [chemical binding]; other site 272630009048 Mg2+ binding site [ion binding]; other site 272630009049 G-X-G motif; other site 272630009050 Response regulator receiver domain; Region: Response_reg; pfam00072 272630009051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630009052 active site 272630009053 phosphorylation site [posttranslational modification] 272630009054 intermolecular recognition site; other site 272630009055 dimerization interface [polypeptide binding]; other site 272630009056 Response regulator receiver domain; Region: Response_reg; pfam00072 272630009057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630009058 active site 272630009059 phosphorylation site [posttranslational modification] 272630009060 intermolecular recognition site; other site 272630009061 dimerization interface [polypeptide binding]; other site 272630009062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630009063 DNA binding residues [nucleotide binding] 272630009064 dimerization interface [polypeptide binding]; other site 272630009065 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 272630009066 similar to hypothetical protein; Evidence 6 : Doubtful CDS 272630009067 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 272630009068 active site 272630009069 SAM binding site [chemical binding]; other site 272630009070 homodimer interface [polypeptide binding]; other site 272630009071 Predicted periplasmic protein [Function unknown]; Region: COG3904 272630009072 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272630009073 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272630009074 P-loop; other site 272630009075 Magnesium ion binding site [ion binding]; other site 272630009076 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 272630009077 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 272630009078 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 272630009079 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 272630009080 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 272630009081 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272630009082 active site 272630009083 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 272630009084 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 272630009085 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272630009086 active site 272630009087 HIGH motif; other site 272630009088 KMSK motif region; other site 272630009089 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272630009090 tRNA binding surface [nucleotide binding]; other site 272630009091 anticodon binding site; other site 272630009092 Sporulation related domain; Region: SPOR; pfam05036 272630009093 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 272630009094 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 272630009095 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 272630009096 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 272630009097 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 272630009098 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272630009099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630009100 putative substrate translocation pore; other site 272630009101 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 272630009102 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272630009103 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272630009104 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272630009105 substrate binding pocket [chemical binding]; other site 272630009106 membrane-bound complex binding site; other site 272630009107 hinge residues; other site 272630009108 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 272630009109 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272630009110 Walker A/P-loop; other site 272630009111 ATP binding site [chemical binding]; other site 272630009112 Q-loop/lid; other site 272630009113 ABC transporter signature motif; other site 272630009114 Walker B; other site 272630009115 D-loop; other site 272630009116 H-loop/switch region; other site 272630009117 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 272630009118 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 272630009119 active site 272630009120 dimer interface [polypeptide binding]; other site 272630009121 non-prolyl cis peptide bond; other site 272630009122 insertion regions; other site 272630009123 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272630009124 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272630009125 substrate binding pocket [chemical binding]; other site 272630009126 membrane-bound complex binding site; other site 272630009127 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272630009128 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272630009129 substrate binding pocket [chemical binding]; other site 272630009130 membrane-bound complex binding site; other site 272630009131 hinge residues; other site 272630009132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 272630009133 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 272630009134 cytidine deaminase; Provisional; Region: PRK09027 272630009135 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 272630009136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 272630009137 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 272630009138 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 272630009139 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272630009140 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272630009141 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 272630009142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 272630009143 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 272630009144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 272630009145 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 272630009146 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272630009147 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 272630009148 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272630009149 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272630009150 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272630009151 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272630009152 classical (c) SDRs; Region: SDR_c; cd05233 272630009153 NAD(P) binding site [chemical binding]; other site 272630009154 active site 272630009155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630009156 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 272630009157 putative substrate translocation pore; other site 272630009158 Beta-lactamase; Region: Beta-lactamase; pfam00144 272630009159 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272630009160 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 272630009161 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 272630009162 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 272630009163 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272630009164 NAD(P) binding site [chemical binding]; other site 272630009165 catalytic residues [active] 272630009166 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272630009167 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630009168 dimerization interface [polypeptide binding]; other site 272630009169 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630009170 dimer interface [polypeptide binding]; other site 272630009171 putative CheW interface [polypeptide binding]; other site 272630009172 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 272630009173 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 272630009174 dimer interface [polypeptide binding]; other site 272630009175 active site 272630009176 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272630009177 catalytic residues [active] 272630009178 substrate binding site [chemical binding]; other site 272630009179 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 272630009180 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272630009181 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272630009182 acyl-activating enzyme (AAE) consensus motif; other site 272630009183 acyl-activating enzyme (AAE) consensus motif; other site 272630009184 AMP binding site [chemical binding]; other site 272630009185 active site 272630009186 CoA binding site [chemical binding]; other site 272630009187 CoA binding site [chemical binding]; other site 272630009188 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 272630009189 Predicted membrane protein [Function unknown]; Region: COG2259 272630009190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630009191 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272630009192 putative substrate translocation pore; other site 272630009193 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 272630009194 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 272630009195 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272630009196 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272630009197 active site 272630009198 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 272630009199 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 272630009200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630009201 S-adenosylmethionine binding site [chemical binding]; other site 272630009202 exopolyphosphatase; Region: exo_poly_only; TIGR03706 272630009203 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 272630009204 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272630009205 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 272630009206 active site 272630009207 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 272630009208 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 272630009209 putative acyl-acceptor binding pocket; other site 272630009210 phytoene desaturase; Region: crtI_fam; TIGR02734 272630009211 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 272630009212 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 272630009213 catalytic triad [active] 272630009214 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272630009215 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272630009216 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 272630009217 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272630009218 Walker A/P-loop; other site 272630009219 ATP binding site [chemical binding]; other site 272630009220 Q-loop/lid; other site 272630009221 ABC transporter signature motif; other site 272630009222 Walker B; other site 272630009223 D-loop; other site 272630009224 H-loop/switch region; other site 272630009225 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 272630009226 phytoene desaturase; Region: crtI_fam; TIGR02734 272630009227 HerA helicase [Replication, recombination, and repair]; Region: COG0433 272630009228 Domain of unknown function DUF87; Region: DUF87; pfam01935 272630009229 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 272630009230 putative active site [active] 272630009231 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272630009232 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 272630009233 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 272630009234 dimer interaction site [polypeptide binding]; other site 272630009235 substrate-binding tunnel; other site 272630009236 active site 272630009237 catalytic site [active] 272630009238 substrate binding site [chemical binding]; other site 272630009239 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 272630009240 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 272630009241 putative active site [active] 272630009242 putative metal binding site [ion binding]; other site 272630009243 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272630009244 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 272630009245 putative C-terminal domain interface [polypeptide binding]; other site 272630009246 putative GSH binding site (G-site) [chemical binding]; other site 272630009247 putative dimer interface [polypeptide binding]; other site 272630009248 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 272630009249 dimer interface [polypeptide binding]; other site 272630009250 N-terminal domain interface [polypeptide binding]; other site 272630009251 putative substrate binding pocket (H-site) [chemical binding]; other site 272630009252 Amidinotransferase; Region: Amidinotransf; cl12043 272630009253 putative membrane protein; Region: HpnL; TIGR03476 272630009254 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 272630009255 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 272630009256 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 272630009257 ligand binding site; other site 272630009258 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 272630009259 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 272630009260 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630009261 FeS/SAM binding site; other site 272630009262 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 272630009263 putative active site [active] 272630009264 YdjC motif; other site 272630009265 Mg binding site [ion binding]; other site 272630009266 putative homodimer interface [polypeptide binding]; other site 272630009267 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 272630009268 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 272630009269 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630009270 FeS/SAM binding site; other site 272630009271 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 272630009272 hopanoid-associated phosphorylase; Region: HpnG; TIGR03468 272630009273 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 272630009274 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 272630009275 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 272630009276 AAA domain; Region: AAA_33; pfam13671 272630009277 ATP-binding site [chemical binding]; other site 272630009278 Gluconate-6-phosphate binding site [chemical binding]; other site 272630009279 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272630009280 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272630009281 active site 272630009282 motif I; other site 272630009283 motif II; other site 272630009284 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272630009285 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272630009286 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272630009287 catalytic residue [active] 272630009288 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 272630009289 potential protein location (conserved hypothetical protein) that overlaps protein (Hypothetical protein) 272630009290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 272630009291 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 272630009292 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 272630009293 putative acyltransferase; Provisional; Region: PRK05790 272630009294 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272630009295 dimer interface [polypeptide binding]; other site 272630009296 active site 272630009297 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 272630009298 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 272630009299 NAD(P) binding site [chemical binding]; other site 272630009300 homotetramer interface [polypeptide binding]; other site 272630009301 homodimer interface [polypeptide binding]; other site 272630009302 active site 272630009303 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 272630009304 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 272630009305 putative acyl-acceptor binding pocket; other site 272630009306 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 272630009307 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 272630009308 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 272630009309 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272630009310 FAD binding domain; Region: FAD_binding_4; pfam01565 272630009311 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 272630009312 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 272630009313 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 272630009314 nudix motif; other site 272630009315 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 272630009316 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 272630009317 inhibitor-cofactor binding pocket; inhibition site 272630009318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630009319 catalytic residue [active] 272630009320 Recombinase; Region: Recombinase; pfam07508 272630009321 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 272630009322 PBP superfamily domain; Region: PBP_like; pfam12727 272630009323 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272630009324 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272630009325 ligand binding site [chemical binding]; other site 272630009326 flexible hinge region; other site 272630009327 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272630009328 putative switch regulator; other site 272630009329 non-specific DNA interactions [nucleotide binding]; other site 272630009330 DNA binding site [nucleotide binding] 272630009331 sequence specific DNA binding site [nucleotide binding]; other site 272630009332 putative cAMP binding site [chemical binding]; other site 272630009333 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272630009334 OsmC-like protein; Region: OsmC; pfam02566 272630009335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272630009336 NMT1-like family; Region: NMT1_2; pfam13379 272630009337 NMT1/THI5 like; Region: NMT1; pfam09084 272630009338 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272630009339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630009340 Walker A/P-loop; other site 272630009341 ATP binding site [chemical binding]; other site 272630009342 Q-loop/lid; other site 272630009343 ABC transporter signature motif; other site 272630009344 Walker B; other site 272630009345 D-loop; other site 272630009346 H-loop/switch region; other site 272630009347 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 272630009348 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 272630009349 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 272630009350 active site 272630009351 non-prolyl cis peptide bond; other site 272630009352 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 272630009353 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 272630009354 Walker A/P-loop; other site 272630009355 ATP binding site [chemical binding]; other site 272630009356 Q-loop/lid; other site 272630009357 ABC transporter signature motif; other site 272630009358 Walker B; other site 272630009359 D-loop; other site 272630009360 H-loop/switch region; other site 272630009361 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 272630009362 TM-ABC transporter signature motif; other site 272630009363 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 272630009364 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 272630009365 TM-ABC transporter signature motif; other site 272630009366 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 272630009367 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 272630009368 putative ligand binding site [chemical binding]; other site 272630009369 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 272630009370 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 272630009371 Walker A/P-loop; other site 272630009372 ATP binding site [chemical binding]; other site 272630009373 Q-loop/lid; other site 272630009374 ABC transporter signature motif; other site 272630009375 Walker B; other site 272630009376 D-loop; other site 272630009377 H-loop/switch region; other site 272630009378 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 272630009379 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272630009380 active site 272630009381 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272630009382 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 272630009383 putative dimer interface [polypeptide binding]; other site 272630009384 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272630009385 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272630009386 ligand binding site [chemical binding]; other site 272630009387 flexible hinge region; other site 272630009388 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 272630009389 Universal stress protein family; Region: Usp; pfam00582 272630009390 Ligand Binding Site [chemical binding]; other site 272630009391 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272630009392 Ligand Binding Site [chemical binding]; other site 272630009393 Protein required for attachment to host cells; Region: Host_attach; pfam10116 272630009394 BON domain; Region: BON; cl02771 272630009395 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272630009396 Ligand Binding Site [chemical binding]; other site 272630009397 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272630009398 ligand binding site [chemical binding]; other site 272630009399 flexible hinge region; other site 272630009400 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272630009401 putative switch regulator; other site 272630009402 non-specific DNA interactions [nucleotide binding]; other site 272630009403 DNA binding site [nucleotide binding] 272630009404 sequence specific DNA binding site [nucleotide binding]; other site 272630009405 putative cAMP binding site [chemical binding]; other site 272630009406 response regulator FixJ; Provisional; Region: fixJ; PRK09390 272630009407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630009408 active site 272630009409 phosphorylation site [posttranslational modification] 272630009410 intermolecular recognition site; other site 272630009411 dimerization interface [polypeptide binding]; other site 272630009412 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630009413 DNA binding residues [nucleotide binding] 272630009414 dimerization interface [polypeptide binding]; other site 272630009415 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630009416 PAS fold; Region: PAS_3; pfam08447 272630009417 putative active site [active] 272630009418 heme pocket [chemical binding]; other site 272630009419 PAS domain S-box; Region: sensory_box; TIGR00229 272630009420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630009421 putative active site [active] 272630009422 heme pocket [chemical binding]; other site 272630009423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630009424 dimer interface [polypeptide binding]; other site 272630009425 phosphorylation site [posttranslational modification] 272630009426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630009427 ATP binding site [chemical binding]; other site 272630009428 Mg2+ binding site [ion binding]; other site 272630009429 G-X-G motif; other site 272630009430 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272630009431 Ligand Binding Site [chemical binding]; other site 272630009432 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630009433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630009434 active site 272630009435 phosphorylation site [posttranslational modification] 272630009436 intermolecular recognition site; other site 272630009437 dimerization interface [polypeptide binding]; other site 272630009438 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272630009439 Zn2+ binding site [ion binding]; other site 272630009440 Mg2+ binding site [ion binding]; other site 272630009441 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 272630009442 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630009443 dimer interface [polypeptide binding]; other site 272630009444 phosphorylation site [posttranslational modification] 272630009445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630009446 ATP binding site [chemical binding]; other site 272630009447 Mg2+ binding site [ion binding]; other site 272630009448 G-X-G motif; other site 272630009449 Response regulator receiver domain; Region: Response_reg; pfam00072 272630009450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630009451 active site 272630009452 phosphorylation site [posttranslational modification] 272630009453 intermolecular recognition site; other site 272630009454 dimerization interface [polypeptide binding]; other site 272630009455 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272630009456 putative binding surface; other site 272630009457 active site 272630009458 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 272630009459 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 272630009460 TadE-like protein; Region: TadE; pfam07811 272630009461 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 272630009462 TadE-like protein; Region: TadE; pfam07811 272630009463 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 272630009464 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272630009465 tetramer interface [polypeptide binding]; other site 272630009466 catalytic Zn binding site [ion binding]; other site 272630009467 NADP binding site [chemical binding]; other site 272630009468 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272630009469 active site 272630009470 catalytic residues [active] 272630009471 DNA binding site [nucleotide binding] 272630009472 Int/Topo IB signature motif; other site 272630009473 non-specific DNA binding site [nucleotide binding]; other site 272630009474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 272630009475 salt bridge; other site 272630009476 sequence-specific DNA binding site [nucleotide binding]; other site 272630009477 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 272630009478 Predicted transcriptional regulator [Transcription]; Region: COG1959 272630009479 Transcriptional regulator; Region: Rrf2; cl17282 272630009480 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 272630009481 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 272630009482 heme-binding site [chemical binding]; other site 272630009483 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 272630009484 FAD binding pocket [chemical binding]; other site 272630009485 FAD binding motif [chemical binding]; other site 272630009486 phosphate binding motif [ion binding]; other site 272630009487 beta-alpha-beta structure motif; other site 272630009488 NAD binding pocket [chemical binding]; other site 272630009489 Heme binding pocket [chemical binding]; other site 272630009490 PAS domain; Region: PAS_9; pfam13426 272630009491 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630009492 putative active site [active] 272630009493 heme pocket [chemical binding]; other site 272630009494 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 272630009495 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 272630009496 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 272630009497 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 272630009498 putative active site [active] 272630009499 Zn binding site [ion binding]; other site 272630009500 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272630009501 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272630009502 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 272630009503 putative dimer interface [polypeptide binding]; other site 272630009504 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272630009505 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272630009506 ligand binding site [chemical binding]; other site 272630009507 flexible hinge region; other site 272630009508 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272630009509 putative switch regulator; other site 272630009510 non-specific DNA interactions [nucleotide binding]; other site 272630009511 DNA binding site [nucleotide binding] 272630009512 sequence specific DNA binding site [nucleotide binding]; other site 272630009513 putative cAMP binding site [chemical binding]; other site 272630009514 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272630009515 Ligand Binding Site [chemical binding]; other site 272630009516 Glucokinase; Region: Glucokinase; cl17310 272630009517 Glucokinase; Region: Glucokinase; cl17310 272630009518 Cytochrome c; Region: Cytochrom_C; cl11414 272630009519 potential protein location (Conserved hypothetical protein) that overlaps protein (Hypothetical protein) 272630009520 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272630009521 E3 interaction surface; other site 272630009522 lipoyl attachment site [posttranslational modification]; other site 272630009523 Ion channel; Region: Ion_trans_2; pfam07885 272630009524 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 272630009525 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 272630009526 response regulator; Provisional; Region: PRK13435 272630009527 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 272630009528 BON domain; Region: BON; pfam04972 272630009529 BON domain; Region: BON; pfam04972 272630009530 BON domain; Region: BON; pfam04972 272630009531 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 272630009532 Ligand Binding Site [chemical binding]; other site 272630009533 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272630009534 Ligand Binding Site [chemical binding]; other site 272630009535 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272630009536 Ligand Binding Site [chemical binding]; other site 272630009537 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272630009538 Cytochrome c; Region: Cytochrom_C; pfam00034 272630009539 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272630009540 Ligand Binding Site [chemical binding]; other site 272630009541 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272630009542 Ligand Binding Site [chemical binding]; other site 272630009543 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 272630009544 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 272630009545 putative NAD(P) binding site [chemical binding]; other site 272630009546 putative substrate binding site [chemical binding]; other site 272630009547 catalytic Zn binding site [ion binding]; other site 272630009548 structural Zn binding site [ion binding]; other site 272630009549 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 272630009550 BON domain; Region: BON; pfam04972 272630009551 BON domain; Region: BON; pfam04972 272630009552 BON domain; Region: BON; pfam04972 272630009553 putative phosphoketolase; Provisional; Region: PRK05261 272630009554 XFP N-terminal domain; Region: XFP_N; pfam09364 272630009555 XFP C-terminal domain; Region: XFP_C; pfam09363 272630009556 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 272630009557 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 272630009558 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272630009559 amphipathic channel; other site 272630009560 Asn-Pro-Ala signature motifs; other site 272630009561 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 272630009562 BON domain; Region: BON; pfam04972 272630009563 BON domain; Region: BON; pfam04972 272630009564 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 272630009565 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 272630009566 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 272630009567 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272630009568 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272630009569 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272630009570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272630009571 motif II; other site 272630009572 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272630009573 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272630009574 Ligand Binding Site [chemical binding]; other site 272630009575 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272630009576 ligand binding site [chemical binding]; other site 272630009577 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272630009578 putative switch regulator; other site 272630009579 non-specific DNA interactions [nucleotide binding]; other site 272630009580 DNA binding site [nucleotide binding] 272630009581 sequence specific DNA binding site [nucleotide binding]; other site 272630009582 putative cAMP binding site [chemical binding]; other site 272630009583 Phasin protein; Region: Phasin_2; cl11491 272630009584 Response regulator receiver domain; Region: Response_reg; pfam00072 272630009585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630009586 active site 272630009587 phosphorylation site [posttranslational modification] 272630009588 intermolecular recognition site; other site 272630009589 dimerization interface [polypeptide binding]; other site 272630009590 response regulator FixJ; Provisional; Region: fixJ; PRK09390 272630009591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630009592 active site 272630009593 phosphorylation site [posttranslational modification] 272630009594 intermolecular recognition site; other site 272630009595 dimerization interface [polypeptide binding]; other site 272630009596 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630009597 DNA binding residues [nucleotide binding] 272630009598 dimerization interface [polypeptide binding]; other site 272630009599 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630009600 PAS fold; Region: PAS_3; pfam08447 272630009601 putative active site [active] 272630009602 heme pocket [chemical binding]; other site 272630009603 PAS domain S-box; Region: sensory_box; TIGR00229 272630009604 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630009605 putative active site [active] 272630009606 heme pocket [chemical binding]; other site 272630009607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630009608 dimer interface [polypeptide binding]; other site 272630009609 phosphorylation site [posttranslational modification] 272630009610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630009611 ATP binding site [chemical binding]; other site 272630009612 Mg2+ binding site [ion binding]; other site 272630009613 G-X-G motif; other site 272630009614 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272630009615 Ligand Binding Site [chemical binding]; other site 272630009616 Cytochrome c; Region: Cytochrom_C; pfam00034 272630009617 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272630009618 Ligand Binding Site [chemical binding]; other site 272630009619 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272630009620 Ligand Binding Site [chemical binding]; other site 272630009621 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 272630009622 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272630009623 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272630009624 putative catalytic site [active] 272630009625 putative metal binding site [ion binding]; other site 272630009626 putative phosphate binding site [ion binding]; other site 272630009627 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 272630009628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272630009629 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630009630 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 272630009631 manganese transport regulator MntR; Provisional; Region: PRK11050 272630009632 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 272630009633 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 272630009634 manganese transport protein MntH; Reviewed; Region: PRK00701 272630009635 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 272630009636 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630009637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630009638 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 272630009639 putative dimerization interface [polypeptide binding]; other site 272630009640 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 272630009641 transmembrane helices; other site 272630009642 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 272630009643 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 272630009644 Iron-sulfur protein interface; other site 272630009645 proximal quinone binding site [chemical binding]; other site 272630009646 SdhD (CybS) interface [polypeptide binding]; other site 272630009647 proximal heme binding site [chemical binding]; other site 272630009648 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 272630009649 putative SdhC subunit interface [polypeptide binding]; other site 272630009650 putative proximal heme binding site [chemical binding]; other site 272630009651 putative Iron-sulfur protein interface [polypeptide binding]; other site 272630009652 putative proximal quinone binding site; other site 272630009653 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 272630009654 L-aspartate oxidase; Provisional; Region: PRK06175 272630009655 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272630009656 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 272630009657 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 272630009658 Protease inhibitor Inh; Region: Inh; pfam02974 272630009659 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 272630009660 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 272630009661 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 272630009662 putative active site [active] 272630009663 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 272630009664 Protein of unknown function, DUF606; Region: DUF606; pfam04657 272630009665 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272630009666 substrate binding site [chemical binding]; other site 272630009667 oxyanion hole (OAH) forming residues; other site 272630009668 trimer interface [polypeptide binding]; other site 272630009669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630009670 NAD(P) binding site [chemical binding]; other site 272630009671 active site 272630009672 short chain dehydrogenase; Provisional; Region: PRK08278 272630009673 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 272630009674 NAD(P) binding site [chemical binding]; other site 272630009675 homodimer interface [polypeptide binding]; other site 272630009676 active site 272630009677 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 272630009678 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 272630009679 Cl binding site [ion binding]; other site 272630009680 oligomer interface [polypeptide binding]; other site 272630009681 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 272630009682 dimerization interface [polypeptide binding]; other site 272630009683 metal binding site [ion binding]; metal-binding site 272630009684 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 272630009685 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630009686 dimer interface [polypeptide binding]; other site 272630009687 putative CheW interface [polypeptide binding]; other site 272630009688 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272630009689 endonuclease III; Region: ENDO3c; smart00478 272630009690 minor groove reading motif; other site 272630009691 helix-hairpin-helix signature motif; other site 272630009692 substrate binding pocket [chemical binding]; other site 272630009693 active site 272630009694 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 272630009695 short chain dehydrogenase; Provisional; Region: PRK06197 272630009696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630009697 NAD(P) binding site [chemical binding]; other site 272630009698 active site 272630009699 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 272630009700 Fasciclin domain; Region: Fasciclin; pfam02469 272630009701 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272630009702 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272630009703 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272630009704 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 272630009705 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272630009706 GAF domain; Region: GAF; cl17456 272630009707 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 272630009708 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272630009709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630009710 dimer interface [polypeptide binding]; other site 272630009711 conserved gate region; other site 272630009712 putative PBP binding loops; other site 272630009713 ABC-ATPase subunit interface; other site 272630009714 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272630009715 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 272630009716 putative C-terminal domain interface [polypeptide binding]; other site 272630009717 putative GSH binding site (G-site) [chemical binding]; other site 272630009718 putative dimer interface [polypeptide binding]; other site 272630009719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630009720 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 272630009721 Walker A/P-loop; other site 272630009722 ATP binding site [chemical binding]; other site 272630009723 Q-loop/lid; other site 272630009724 ABC transporter signature motif; other site 272630009725 Walker B; other site 272630009726 D-loop; other site 272630009727 H-loop/switch region; other site 272630009728 TOBE domain; Region: TOBE; cl01440 272630009729 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 272630009730 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 272630009731 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 272630009732 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 272630009733 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272630009734 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630009735 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272630009736 PGAP1-like protein; Region: PGAP1; pfam07819 272630009737 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272630009738 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272630009739 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272630009740 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272630009741 LrgB-like family; Region: LrgB; pfam04172 272630009742 LrgA family; Region: LrgA; pfam03788 272630009743 tellurium resistance terB-like protein; Region: terB_like; cl11965 272630009744 metal binding site [ion binding]; metal-binding site 272630009745 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272630009746 Methyltransferase domain; Region: Methyltransf_11; pfam08241 272630009747 S-adenosylmethionine binding site [chemical binding]; other site 272630009748 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 272630009749 OstA-like protein; Region: OstA; cl00844 272630009750 Organic solvent tolerance protein; Region: OstA_C; pfam04453 272630009751 Predicted permeases [General function prediction only]; Region: COG0795 272630009752 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 272630009753 Predicted permeases [General function prediction only]; Region: COG0795 272630009754 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 272630009755 multifunctional aminopeptidase A; Provisional; Region: PRK00913 272630009756 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272630009757 interface (dimer of trimers) [polypeptide binding]; other site 272630009758 Substrate-binding/catalytic site; other site 272630009759 Zn-binding sites [ion binding]; other site 272630009760 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 272630009761 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 272630009762 acyl-activating enzyme (AAE) consensus motif; other site 272630009763 putative AMP binding site [chemical binding]; other site 272630009764 putative active site [active] 272630009765 putative CoA binding site [chemical binding]; other site 272630009766 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272630009767 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272630009768 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 272630009769 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 272630009770 catalytic residues [active] 272630009771 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272630009772 Zn2+ binding site [ion binding]; other site 272630009773 Mg2+ binding site [ion binding]; other site 272630009774 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 272630009775 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 272630009776 hypothetical protein; Provisional; Region: PRK08960 272630009777 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272630009778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630009779 homodimer interface [polypeptide binding]; other site 272630009780 catalytic residue [active] 272630009781 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 272630009782 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272630009783 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 272630009784 AMIN domain; Region: AMIN; pfam11741 272630009785 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272630009786 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272630009787 active site 272630009788 metal binding site [ion binding]; metal-binding site 272630009789 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 272630009790 Transglycosylase; Region: Transgly; pfam00912 272630009791 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272630009792 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 272630009793 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 272630009794 active site 272630009795 dimer interface [polypeptide binding]; other site 272630009796 non-prolyl cis peptide bond; other site 272630009797 insertion regions; other site 272630009798 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 272630009799 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 272630009800 Flavin binding site [chemical binding]; other site 272630009801 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 272630009802 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 272630009803 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 272630009804 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 272630009805 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 272630009806 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 272630009807 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272630009808 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272630009809 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 272630009810 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 272630009811 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 272630009812 RibD C-terminal domain; Region: RibD_C; cl17279 272630009813 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 272630009814 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 272630009815 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 272630009816 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 272630009817 Ligand binding site; other site 272630009818 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 272630009819 DXD motif; other site 272630009820 integrase; Provisional; Region: PRK09692 272630009821 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 272630009822 active site 272630009823 Int/Topo IB signature motif; other site 272630009824 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 272630009825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630009826 Walker A/P-loop; other site 272630009827 ATP binding site [chemical binding]; other site 272630009828 HNH endonuclease; Region: HNH_3; pfam13392 272630009829 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 272630009830 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272630009831 DnaA box-binding interface [nucleotide binding]; other site 272630009832 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272630009833 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272630009834 active site 272630009835 HNH endonuclease; Region: HNH_3; pfam13392 272630009836 NinB protein; Region: NinB; pfam05772 272630009837 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 272630009838 ParB-like nuclease domain; Region: ParB; smart00470 272630009839 Endodeoxyribonuclease RusA; Region: RusA; cl01885 272630009840 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272630009841 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 272630009842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630009843 nucleotide binding region [chemical binding]; other site 272630009844 ATP-binding site [chemical binding]; other site 272630009845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 272630009846 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 272630009847 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 272630009848 active site 272630009849 metal binding site [ion binding]; metal-binding site 272630009850 interdomain interaction site; other site 272630009851 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u5; cd11542 272630009852 metal binding site [ion binding]; metal-binding site 272630009853 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272630009854 heterodimer interface [polypeptide binding]; other site 272630009855 homodimer interface [polypeptide binding]; other site 272630009856 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 272630009857 Phage terminase large subunit; Region: Terminase_3; cl12054 272630009858 Terminase-like family; Region: Terminase_6; pfam03237 272630009859 HNH endonuclease; Region: HNH_3; pfam13392 272630009860 AP2 domain; Region: AP2; pfam00847 272630009861 DNA binding site [nucleotide binding] 272630009862 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 272630009863 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 272630009864 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 272630009865 Phage Tail Collar Domain; Region: Collar; pfam07484 272630009866 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 272630009867 catalytic residues [active] 272630009868 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272630009869 P63C domain; Region: P63C; pfam10546 272630009870 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 272630009871 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272630009872 active site 272630009873 metal binding site [ion binding]; metal-binding site 272630009874 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 272630009875 Right handed beta helix region; Region: Beta_helix; pfam13229 272630009876 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 272630009877 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 272630009878 substrate binding site; other site 272630009879 tetramer interface; other site 272630009880 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 272630009881 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 272630009882 NADP binding site [chemical binding]; other site 272630009883 active site 272630009884 putative substrate binding site [chemical binding]; other site 272630009885 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 272630009886 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 272630009887 NAD binding site [chemical binding]; other site 272630009888 substrate binding site [chemical binding]; other site 272630009889 homodimer interface [polypeptide binding]; other site 272630009890 active site 272630009891 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 272630009892 Protein of unknown function (DUF3768); Region: DUF3768; pfam12599 272630009893 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272630009894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630009895 non-specific DNA binding site [nucleotide binding]; other site 272630009896 salt bridge; other site 272630009897 sequence-specific DNA binding site [nucleotide binding]; other site 272630009898 Poxvirus protein F15; Region: Pox_F15; cl17587 272630009899 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 272630009900 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 272630009901 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 272630009902 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 272630009903 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272630009904 active site 272630009905 Int/Topo IB signature motif; other site 272630009906 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 272630009907 allophanate hydrolase; Provisional; Region: PRK08186 272630009908 Amidase; Region: Amidase; cl11426 272630009909 urea carboxylase; Region: urea_carbox; TIGR02712 272630009910 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272630009911 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272630009912 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 272630009913 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 272630009914 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 272630009915 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272630009916 carboxyltransferase (CT) interaction site; other site 272630009917 biotinylation site [posttranslational modification]; other site 272630009918 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 272630009919 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 272630009920 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 272630009921 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 272630009922 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 272630009923 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 272630009924 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272630009925 Creatinine amidohydrolase; Region: Creatininase; pfam02633 272630009926 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272630009927 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272630009928 Walker A/P-loop; other site 272630009929 ATP binding site [chemical binding]; other site 272630009930 Q-loop/lid; other site 272630009931 ABC transporter signature motif; other site 272630009932 Walker B; other site 272630009933 D-loop; other site 272630009934 H-loop/switch region; other site 272630009935 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272630009936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630009937 dimer interface [polypeptide binding]; other site 272630009938 conserved gate region; other site 272630009939 putative PBP binding loops; other site 272630009940 ABC-ATPase subunit interface; other site 272630009941 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272630009942 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 272630009943 ykkC-yxkD element; MexAM1_META1pmiscRNA8 272630009944 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 272630009945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630009946 Walker A/P-loop; other site 272630009947 ATP binding site [chemical binding]; other site 272630009948 Q-loop/lid; other site 272630009949 ABC transporter signature motif; other site 272630009950 Walker B; other site 272630009951 D-loop; other site 272630009952 H-loop/switch region; other site 272630009953 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 272630009954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630009955 dimer interface [polypeptide binding]; other site 272630009956 conserved gate region; other site 272630009957 putative PBP binding loops; other site 272630009958 ABC-ATPase subunit interface; other site 272630009959 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 272630009960 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 272630009961 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 272630009962 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 272630009963 conserved cys residue [active] 272630009964 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272630009965 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 272630009966 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272630009967 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 272630009968 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 272630009969 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 272630009970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272630009971 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 272630009972 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272630009973 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 272630009974 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 272630009975 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 272630009976 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 272630009977 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 272630009978 putative deacylase active site [active] 272630009979 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 272630009980 Electron transfer flavoprotein domain; Region: ETF; pfam01012 272630009981 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 272630009982 Electron transfer flavoprotein domain; Region: ETF; smart00893 272630009983 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 272630009984 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 272630009985 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 272630009986 4Fe-4S binding domain; Region: Fer4; cl02805 272630009987 Cysteine-rich domain; Region: CCG; pfam02754 272630009988 Cysteine-rich domain; Region: CCG; pfam02754 272630009989 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 272630009990 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 272630009991 putative active site [active] 272630009992 putative FMN binding site [chemical binding]; other site 272630009993 putative substrate binding site [chemical binding]; other site 272630009994 putative catalytic residue [active] 272630009995 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272630009996 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 272630009997 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 272630009998 FAD binding pocket [chemical binding]; other site 272630009999 FAD binding motif [chemical binding]; other site 272630010000 phosphate binding motif [ion binding]; other site 272630010001 beta-alpha-beta structure motif; other site 272630010002 NAD binding pocket [chemical binding]; other site 272630010003 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272630010004 catalytic loop [active] 272630010005 iron binding site [ion binding]; other site 272630010006 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 272630010007 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 272630010008 [2Fe-2S] cluster binding site [ion binding]; other site 272630010009 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 272630010010 putative alpha subunit interface [polypeptide binding]; other site 272630010011 putative active site [active] 272630010012 putative substrate binding site [chemical binding]; other site 272630010013 Fe binding site [ion binding]; other site 272630010014 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272630010015 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 272630010016 active site 272630010017 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 272630010018 Phosphotransferase enzyme family; Region: APH; pfam01636 272630010019 active site 272630010020 ATP binding site [chemical binding]; other site 272630010021 substrate binding site [chemical binding]; other site 272630010022 dimer interface [polypeptide binding]; other site 272630010023 Phosphotransferase enzyme family; Region: APH; pfam01636 272630010024 active site 272630010025 ATP binding site [chemical binding]; other site 272630010026 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272630010027 substrate binding site [chemical binding]; other site 272630010028 allantoate amidohydrolase; Reviewed; Region: PRK09290 272630010029 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 272630010030 active site 272630010031 metal binding site [ion binding]; metal-binding site 272630010032 dimer interface [polypeptide binding]; other site 272630010033 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272630010034 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272630010035 Walker A/P-loop; other site 272630010036 ATP binding site [chemical binding]; other site 272630010037 Q-loop/lid; other site 272630010038 ABC transporter signature motif; other site 272630010039 Walker B; other site 272630010040 D-loop; other site 272630010041 H-loop/switch region; other site 272630010042 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272630010043 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272630010044 Walker A/P-loop; other site 272630010045 ATP binding site [chemical binding]; other site 272630010046 Q-loop/lid; other site 272630010047 ABC transporter signature motif; other site 272630010048 Walker B; other site 272630010049 D-loop; other site 272630010050 H-loop/switch region; other site 272630010051 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272630010052 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272630010053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630010054 dimer interface [polypeptide binding]; other site 272630010055 conserved gate region; other site 272630010056 putative PBP binding loops; other site 272630010057 ABC-ATPase subunit interface; other site 272630010058 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272630010059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630010060 dimer interface [polypeptide binding]; other site 272630010061 conserved gate region; other site 272630010062 putative PBP binding loops; other site 272630010063 ABC-ATPase subunit interface; other site 272630010064 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 272630010065 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 272630010066 Secretin and TonB N terminus short domain; Region: STN; smart00965 272630010067 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 272630010068 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272630010069 N-terminal plug; other site 272630010070 ligand-binding site [chemical binding]; other site 272630010071 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 272630010072 FecR protein; Region: FecR; pfam04773 272630010073 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 272630010074 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630010075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272630010076 DNA binding residues [nucleotide binding] 272630010077 IucA / IucC family; Region: IucA_IucC; pfam04183 272630010078 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 272630010079 IucA / IucC family; Region: IucA_IucC; pfam04183 272630010080 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 272630010081 acyl-CoA synthetase; Validated; Region: PRK08308 272630010082 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272630010083 acyl-activating enzyme (AAE) consensus motif; other site 272630010084 AMP binding site [chemical binding]; other site 272630010085 active site 272630010086 CoA binding site [chemical binding]; other site 272630010087 acyl carrier protein; Provisional; Region: PRK07639 272630010088 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 272630010089 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272630010090 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 272630010091 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 272630010092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272630010093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272630010094 Coenzyme A binding pocket [chemical binding]; other site 272630010095 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 272630010096 TetR family transcriptional regulator; Provisional; Region: PRK14996 272630010097 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 272630010098 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 272630010099 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 272630010100 Membrane fusogenic activity; Region: BMFP; pfam04380 272630010101 osmolarity response regulator; Provisional; Region: ompR; PRK09468 272630010102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630010103 active site 272630010104 phosphorylation site [posttranslational modification] 272630010105 intermolecular recognition site; other site 272630010106 dimerization interface [polypeptide binding]; other site 272630010107 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630010108 DNA binding site [nucleotide binding] 272630010109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630010110 dimer interface [polypeptide binding]; other site 272630010111 phosphorylation site [posttranslational modification] 272630010112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630010113 ATP binding site [chemical binding]; other site 272630010114 Mg2+ binding site [ion binding]; other site 272630010115 G-X-G motif; other site 272630010116 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630010117 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630010118 metal binding site [ion binding]; metal-binding site 272630010119 active site 272630010120 I-site; other site 272630010121 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 272630010122 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272630010123 putative C-terminal domain interface [polypeptide binding]; other site 272630010124 putative GSH binding site (G-site) [chemical binding]; other site 272630010125 putative dimer interface [polypeptide binding]; other site 272630010126 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 272630010127 putative N-terminal domain interface [polypeptide binding]; other site 272630010128 putative substrate binding pocket (H-site) [chemical binding]; other site 272630010129 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 272630010130 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 272630010131 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 272630010132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630010133 active site 272630010134 phosphorylation site [posttranslational modification] 272630010135 intermolecular recognition site; other site 272630010136 dimerization interface [polypeptide binding]; other site 272630010137 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 272630010138 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 272630010139 putative active site [active] 272630010140 putative dimer interface [polypeptide binding]; other site 272630010141 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272630010142 hypothetical protein; Provisional; Region: PRK10621 272630010143 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 272630010144 putative active site [active] 272630010145 putative catalytic site [active] 272630010146 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 272630010147 putative active site [active] 272630010148 putative catalytic site [active] 272630010149 YGGT family; Region: YGGT; pfam02325 272630010150 potential frameshift: common BLAST hit: gi|188583379|ref|YP_001926824.1| protein of unknown function DUF159 272630010151 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 272630010152 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 272630010153 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272630010154 GAF domain; Region: GAF; pfam01590 272630010155 PAS domain; Region: PAS_9; pfam13426 272630010156 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630010157 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630010158 metal binding site [ion binding]; metal-binding site 272630010159 active site 272630010160 I-site; other site 272630010161 GAF domain; Region: GAF; pfam01590 272630010162 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272630010163 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630010164 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 272630010165 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272630010166 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272630010167 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 272630010168 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272630010169 putative active site [active] 272630010170 heme pocket [chemical binding]; other site 272630010171 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 272630010172 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272630010173 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 272630010174 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272630010175 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630010176 DNA binding residues [nucleotide binding] 272630010177 dimerization interface [polypeptide binding]; other site 272630010178 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 272630010179 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 272630010180 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 272630010181 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 272630010182 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 272630010183 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 272630010184 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272630010185 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272630010186 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 272630010187 TAP-like protein; Region: Abhydrolase_4; pfam08386 272630010188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630010189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630010190 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272630010191 dimerization interface [polypeptide binding]; other site 272630010192 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 272630010193 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272630010194 GAF domain; Region: GAF; pfam01590 272630010195 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272630010196 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630010197 non-specific DNA binding site [nucleotide binding]; other site 272630010198 salt bridge; other site 272630010199 sequence-specific DNA binding site [nucleotide binding]; other site 272630010200 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630010201 PAS domain; Region: PAS_9; pfam13426 272630010202 putative active site [active] 272630010203 heme pocket [chemical binding]; other site 272630010204 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630010205 PAS domain; Region: PAS_9; pfam13426 272630010206 putative active site [active] 272630010207 heme pocket [chemical binding]; other site 272630010208 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630010209 PAS domain; Region: PAS_9; pfam13426 272630010210 putative active site [active] 272630010211 heme pocket [chemical binding]; other site 272630010212 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630010213 dimer interface [polypeptide binding]; other site 272630010214 putative CheW interface [polypeptide binding]; other site 272630010215 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272630010216 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272630010217 protein binding site [polypeptide binding]; other site 272630010218 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272630010219 protein binding site [polypeptide binding]; other site 272630010220 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272630010221 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 272630010222 Cl- selectivity filter; other site 272630010223 Cl- binding residues [ion binding]; other site 272630010224 pore gating glutamate residue; other site 272630010225 dimer interface [polypeptide binding]; other site 272630010226 H+/Cl- coupling transport residue; other site 272630010227 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272630010228 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272630010229 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630010230 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272630010231 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 272630010232 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 272630010233 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272630010234 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272630010235 dimerization interface [polypeptide binding]; other site 272630010236 putative DNA binding site [nucleotide binding]; other site 272630010237 putative Zn2+ binding site [ion binding]; other site 272630010238 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272630010239 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272630010240 peroxiredoxin; Provisional; Region: PRK13189 272630010241 Putative phosphatase (DUF442); Region: DUF442; cl17385 272630010242 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 272630010243 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272630010244 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 272630010245 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 272630010246 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 272630010247 putative metal binding site [ion binding]; other site 272630010248 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272630010249 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 272630010250 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272630010251 ABC-ATPase subunit interface; other site 272630010252 dimer interface [polypeptide binding]; other site 272630010253 putative PBP binding regions; other site 272630010254 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272630010255 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272630010256 Walker A/P-loop; other site 272630010257 ATP binding site [chemical binding]; other site 272630010258 Q-loop/lid; other site 272630010259 ABC transporter signature motif; other site 272630010260 Walker B; other site 272630010261 D-loop; other site 272630010262 H-loop/switch region; other site 272630010263 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 272630010264 Moco binding site; other site 272630010265 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 272630010266 metal coordination site [ion binding]; other site 272630010267 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 272630010268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630010269 S-adenosylmethionine binding site [chemical binding]; other site 272630010270 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272630010271 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272630010272 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272630010273 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272630010274 active site 272630010275 catalytic tetrad [active] 272630010276 Isochorismatase family; Region: Isochorismatase; pfam00857 272630010277 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 272630010278 catalytic triad [active] 272630010279 conserved cis-peptide bond; other site 272630010280 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272630010281 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630010282 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272630010283 RMQ06452 Microarray probe; Evidence 7 : Gene remnant 272630010284 RMQ06450 Microarray probe; Evidence 7 : Gene remnant 272630010285 TLC ATP/ADP transporter; Region: TLC; cl03940 272630010286 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 272630010287 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 272630010288 RMQ02712 Microarray probe; Evidence 7 : Gene remnant 272630010289 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272630010290 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272630010291 active site 272630010292 catalytic tetrad [active] 272630010293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630010294 S-adenosylmethionine binding site [chemical binding]; other site 272630010295 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272630010296 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272630010297 RNA binding surface [nucleotide binding]; other site 272630010298 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 272630010299 active site 272630010300 RMQ05048 Microarray; Evidence 7 : Gene remnant 272630010301 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 272630010302 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272630010303 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272630010304 dimerization interface [polypeptide binding]; other site 272630010305 putative DNA binding site [nucleotide binding]; other site 272630010306 putative Zn2+ binding site [ion binding]; other site 272630010307 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 272630010308 ArsC family; Region: ArsC; pfam03960 272630010309 catalytic residues [active] 272630010310 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 272630010311 arsenical-resistance protein; Region: acr3; TIGR00832 272630010312 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630010313 PAS domain; Region: PAS_9; pfam13426 272630010314 putative active site [active] 272630010315 heme pocket [chemical binding]; other site 272630010316 PAS fold; Region: PAS_7; pfam12860 272630010317 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630010318 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630010319 metal binding site [ion binding]; metal-binding site 272630010320 active site 272630010321 I-site; other site 272630010322 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630010323 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272630010324 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272630010325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630010326 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272630010327 NAD(P) binding site [chemical binding]; other site 272630010328 active site 272630010329 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272630010330 nucleoside/Zn binding site; other site 272630010331 dimer interface [polypeptide binding]; other site 272630010332 catalytic motif [active] 272630010333 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 272630010334 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 272630010335 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 272630010336 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 272630010337 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 272630010338 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 272630010339 generic binding surface II; other site 272630010340 generic binding surface I; other site 272630010341 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 272630010342 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 272630010343 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272630010344 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272630010345 active site 272630010346 transcription elongation factor regulatory protein; Validated; Region: PRK06342 272630010347 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272630010348 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 272630010349 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 272630010350 NADP binding site [chemical binding]; other site 272630010351 dimer interface [polypeptide binding]; other site 272630010352 Ferredoxin [Energy production and conversion]; Region: COG1146 272630010353 4Fe-4S binding domain; Region: Fer4; pfam00037 272630010354 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 272630010355 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 272630010356 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 272630010357 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630010358 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272630010359 DNA binding residues [nucleotide binding] 272630010360 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272630010361 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 272630010362 Glucose inhibited division protein A; Region: GIDA; pfam01134 272630010363 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272630010364 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 272630010365 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272630010366 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272630010367 protein binding site [polypeptide binding]; other site 272630010368 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 272630010369 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630010370 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272630010371 DNA binding residues [nucleotide binding] 272630010372 Anti-sigma-K factor rskA; Region: RskA; pfam10099 272630010373 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 272630010374 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272630010375 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272630010376 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272630010377 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 272630010378 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630010379 putative CheW interface [polypeptide binding]; other site 272630010380 Nitrate and nitrite sensing; Region: NIT; pfam08376 272630010381 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272630010382 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630010383 dimer interface [polypeptide binding]; other site 272630010384 putative CheW interface [polypeptide binding]; other site 272630010385 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272630010386 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272630010387 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630010388 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 272630010389 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 272630010390 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630010391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 272630010392 active site 272630010393 phosphorylation site [posttranslational modification] 272630010394 intermolecular recognition site; other site 272630010395 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272630010396 GAF domain; Region: GAF; pfam01590 272630010397 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630010398 PAS fold; Region: PAS_3; pfam08447 272630010399 putative active site [active] 272630010400 heme pocket [chemical binding]; other site 272630010401 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630010402 PAS fold; Region: PAS_3; pfam08447 272630010403 putative active site [active] 272630010404 heme pocket [chemical binding]; other site 272630010405 PAS domain S-box; Region: sensory_box; TIGR00229 272630010406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630010407 putative active site [active] 272630010408 heme pocket [chemical binding]; other site 272630010409 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272630010410 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272630010411 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630010412 HWE histidine kinase; Region: HWE_HK; pfam07536 272630010413 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272630010414 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 272630010415 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272630010416 non-specific DNA interactions [nucleotide binding]; other site 272630010417 DNA binding site [nucleotide binding] 272630010418 sequence specific DNA binding site [nucleotide binding]; other site 272630010419 putative cAMP binding site [chemical binding]; other site 272630010420 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 272630010421 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 272630010422 active site 272630010423 Protein of unknown function, DUF488; Region: DUF488; pfam04343 272630010424 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 272630010425 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272630010426 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 272630010427 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 272630010428 NADP binding site [chemical binding]; other site 272630010429 dimer interface [polypeptide binding]; other site 272630010430 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 272630010431 Isochorismatase family; Region: Isochorismatase; pfam00857 272630010432 catalytic triad [active] 272630010433 metal binding site [ion binding]; metal-binding site 272630010434 conserved cis-peptide bond; other site 272630010435 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 272630010436 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 272630010437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630010438 catalytic residue [active] 272630010439 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 272630010440 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272630010441 glutamine binding [chemical binding]; other site 272630010442 catalytic triad [active] 272630010443 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272630010444 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 272630010445 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272630010446 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 272630010447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 272630010448 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 272630010449 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272630010450 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630010451 FeS/SAM binding site; other site 272630010452 Predicted membrane protein [Function unknown]; Region: COG4270 272630010453 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 272630010454 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 272630010455 homodimer interface [polypeptide binding]; other site 272630010456 metal binding site [ion binding]; metal-binding site 272630010457 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 272630010458 homodimer interface [polypeptide binding]; other site 272630010459 active site 272630010460 putative chemical substrate binding site [chemical binding]; other site 272630010461 metal binding site [ion binding]; metal-binding site 272630010462 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 272630010463 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 272630010464 active site 272630010465 nucleophile elbow; other site 272630010466 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 272630010467 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 272630010468 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630010469 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630010470 metal binding site [ion binding]; metal-binding site 272630010471 active site 272630010472 I-site; other site 272630010473 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272630010474 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630010475 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272630010476 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272630010477 Zn2+ binding site [ion binding]; other site 272630010478 Mg2+ binding site [ion binding]; other site 272630010479 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 272630010480 oligomer interface [polypeptide binding]; other site 272630010481 putative active site [active] 272630010482 Mn binding site [ion binding]; other site 272630010483 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 272630010484 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 272630010485 Flavoprotein; Region: Flavoprotein; pfam02441 272630010486 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 272630010487 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 272630010488 ABC1 family; Region: ABC1; cl17513 272630010489 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 272630010490 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 272630010491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630010492 S-adenosylmethionine binding site [chemical binding]; other site 272630010493 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 272630010494 folate binding site [chemical binding]; other site 272630010495 NADP+ binding site [chemical binding]; other site 272630010496 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272630010497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630010498 NAD(P) binding site [chemical binding]; other site 272630010499 active site 272630010500 amidophosphoribosyltransferase; Provisional; Region: PRK09123 272630010501 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 272630010502 active site 272630010503 tetramer interface [polypeptide binding]; other site 272630010504 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272630010505 active site 272630010506 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 272630010507 Colicin V production protein; Region: Colicin_V; pfam02674 272630010508 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 272630010509 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 272630010510 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 272630010511 Cu(I) binding site [ion binding]; other site 272630010512 DNA repair protein RadA; Provisional; Region: PRK11823 272630010513 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 272630010514 Walker A motif/ATP binding site; other site 272630010515 ATP binding site [chemical binding]; other site 272630010516 Walker B motif; other site 272630010517 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272630010518 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 272630010519 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 272630010520 active site 272630010521 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272630010522 dimer interface [polypeptide binding]; other site 272630010523 substrate binding site [chemical binding]; other site 272630010524 catalytic residues [active] 272630010525 replicative DNA helicase; Provisional; Region: PRK09165 272630010526 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272630010527 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272630010528 Walker A motif; other site 272630010529 ATP binding site [chemical binding]; other site 272630010530 Walker B motif; other site 272630010531 DNA binding loops [nucleotide binding] 272630010532 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 272630010533 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272630010534 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272630010535 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 272630010536 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 272630010537 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272630010538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272630010539 Coenzyme A binding pocket [chemical binding]; other site 272630010540 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 272630010541 pentamer interface [polypeptide binding]; other site 272630010542 dodecaamer interface [polypeptide binding]; other site 272630010543 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272630010544 DNA-binding site [nucleotide binding]; DNA binding site 272630010545 RNA-binding motif; other site 272630010546 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272630010547 active site 272630010548 catalytic residues [active] 272630010549 metal binding site [ion binding]; metal-binding site 272630010550 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272630010551 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272630010552 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 272630010553 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272630010554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272630010555 Coenzyme A binding pocket [chemical binding]; other site 272630010556 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 272630010557 fructuronate transporter; Provisional; Region: PRK10034; cl15264 272630010558 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 272630010559 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272630010560 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 272630010561 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 272630010562 NAD(P) binding site [chemical binding]; other site 272630010563 active site 272630010564 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 272630010565 Aspartase; Region: Aspartase; cd01357 272630010566 active sites [active] 272630010567 tetramer interface [polypeptide binding]; other site 272630010568 Porin subfamily; Region: Porin_2; pfam02530 272630010569 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 272630010570 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272630010571 substrate binding pocket [chemical binding]; other site 272630010572 membrane-bound complex binding site; other site 272630010573 hinge residues; other site 272630010574 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272630010575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630010576 dimer interface [polypeptide binding]; other site 272630010577 conserved gate region; other site 272630010578 putative PBP binding loops; other site 272630010579 ABC-ATPase subunit interface; other site 272630010580 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272630010581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630010582 dimer interface [polypeptide binding]; other site 272630010583 conserved gate region; other site 272630010584 putative PBP binding loops; other site 272630010585 ABC-ATPase subunit interface; other site 272630010586 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272630010587 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272630010588 Walker A/P-loop; other site 272630010589 ATP binding site [chemical binding]; other site 272630010590 Q-loop/lid; other site 272630010591 ABC transporter signature motif; other site 272630010592 Walker B; other site 272630010593 D-loop; other site 272630010594 H-loop/switch region; other site 272630010595 Protein of unknown function, DUF606; Region: DUF606; pfam04657 272630010596 Protein of unknown function, DUF606; Region: DUF606; pfam04657 272630010597 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 272630010598 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 272630010599 transmembrane helices; other site 272630010600 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 272630010601 nudix motif; other site 272630010602 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 272630010603 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 272630010604 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 272630010605 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 272630010606 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 272630010607 acyl-activating enzyme (AAE) consensus motif; other site 272630010608 AMP binding site [chemical binding]; other site 272630010609 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272630010610 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 272630010611 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272630010612 putative trimer interface [polypeptide binding]; other site 272630010613 putative CoA binding site [chemical binding]; other site 272630010614 Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309 272630010615 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 272630010616 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272630010617 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 272630010618 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272630010619 catalytic residue [active] 272630010620 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 272630010621 putative ABC transporter; Region: ycf24; CHL00085 272630010622 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 272630010623 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 272630010624 Walker A/P-loop; other site 272630010625 ATP binding site [chemical binding]; other site 272630010626 Q-loop/lid; other site 272630010627 ABC transporter signature motif; other site 272630010628 Walker B; other site 272630010629 D-loop; other site 272630010630 H-loop/switch region; other site 272630010631 FeS assembly protein SufD; Region: sufD; TIGR01981 272630010632 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 272630010633 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272630010634 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272630010635 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272630010636 catalytic residue [active] 272630010637 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 272630010638 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 272630010639 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630010640 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630010641 metal binding site [ion binding]; metal-binding site 272630010642 active site 272630010643 I-site; other site 272630010644 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272630010645 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272630010646 ATP binding site [chemical binding]; other site 272630010647 Mg++ binding site [ion binding]; other site 272630010648 motif III; other site 272630010649 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630010650 nucleotide binding region [chemical binding]; other site 272630010651 ATP-binding site [chemical binding]; other site 272630010652 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 272630010653 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 272630010654 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272630010655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272630010656 motif II; other site 272630010657 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 272630010658 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272630010659 Walker A/P-loop; other site 272630010660 ATP binding site [chemical binding]; other site 272630010661 Q-loop/lid; other site 272630010662 ABC transporter signature motif; other site 272630010663 Walker B; other site 272630010664 D-loop; other site 272630010665 H-loop/switch region; other site 272630010666 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 272630010667 active site 272630010668 catalytic triad [active] 272630010669 oxyanion hole [active] 272630010670 switch loop; other site 272630010671 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 272630010672 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 272630010673 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 272630010674 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 272630010675 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 272630010676 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272630010677 putative homodimer interface [polypeptide binding]; other site 272630010678 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272630010679 heterodimer interface [polypeptide binding]; other site 272630010680 homodimer interface [polypeptide binding]; other site 272630010681 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272630010682 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272630010683 23S rRNA interface [nucleotide binding]; other site 272630010684 L7/L12 interface [polypeptide binding]; other site 272630010685 putative thiostrepton binding site; other site 272630010686 L25 interface [polypeptide binding]; other site 272630010687 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272630010688 mRNA/rRNA interface [nucleotide binding]; other site 272630010689 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 272630010690 Cytochrome P450; Region: p450; cl12078 272630010691 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 272630010692 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272630010693 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272630010694 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 272630010695 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 272630010696 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272630010697 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272630010698 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272630010699 Probable Catalytic site; other site 272630010700 metal-binding site 272630010701 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272630010702 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272630010703 dimer interface [polypeptide binding]; other site 272630010704 anticodon binding site; other site 272630010705 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272630010706 motif 1; other site 272630010707 dimer interface [polypeptide binding]; other site 272630010708 active site 272630010709 motif 2; other site 272630010710 GAD domain; Region: GAD; pfam02938 272630010711 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272630010712 active site 272630010713 motif 3; other site 272630010714 biotin synthase; Region: bioB; TIGR00433 272630010715 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630010716 FeS/SAM binding site; other site 272630010717 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 272630010718 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 272630010719 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 272630010720 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 272630010721 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 272630010722 arogenate dehydrogenase; Region: PLN02256 272630010723 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 272630010724 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 272630010725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630010726 PAS domain; Region: PAS_9; pfam13426 272630010727 putative active site [active] 272630010728 heme pocket [chemical binding]; other site 272630010729 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630010730 metal binding site [ion binding]; metal-binding site 272630010731 active site 272630010732 I-site; other site 272630010733 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630010734 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 272630010735 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 272630010736 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 272630010737 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272630010738 23S rRNA interface [nucleotide binding]; other site 272630010739 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272630010740 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272630010741 L11 interface [polypeptide binding]; other site 272630010742 putative EF-Tu interaction site [polypeptide binding]; other site 272630010743 putative EF-G interaction site [polypeptide binding]; other site 272630010744 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272630010745 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 272630010746 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 272630010747 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272630010748 RPB11 interaction site [polypeptide binding]; other site 272630010749 RPB12 interaction site [polypeptide binding]; other site 272630010750 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272630010751 RPB3 interaction site [polypeptide binding]; other site 272630010752 RPB1 interaction site [polypeptide binding]; other site 272630010753 RPB11 interaction site [polypeptide binding]; other site 272630010754 RPB10 interaction site [polypeptide binding]; other site 272630010755 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 272630010756 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 272630010757 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 272630010758 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 272630010759 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 272630010760 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 272630010761 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 272630010762 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 272630010763 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272630010764 DNA binding site [nucleotide binding] 272630010765 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272630010766 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 272630010767 homotrimer interaction site [polypeptide binding]; other site 272630010768 putative active site [active] 272630010769 Predicted membrane protein [Function unknown]; Region: COG2261 272630010770 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 272630010771 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 272630010772 NADP binding site [chemical binding]; other site 272630010773 Predicted transcriptional regulators [Transcription]; Region: COG1733 272630010774 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272630010775 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272630010776 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 272630010777 putative C-terminal domain interface [polypeptide binding]; other site 272630010778 putative GSH binding site (G-site) [chemical binding]; other site 272630010779 putative dimer interface [polypeptide binding]; other site 272630010780 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 272630010781 dimer interface [polypeptide binding]; other site 272630010782 N-terminal domain interface [polypeptide binding]; other site 272630010783 putative substrate binding pocket (H-site) [chemical binding]; other site 272630010784 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 272630010785 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272630010786 N-terminal plug; other site 272630010787 ligand-binding site [chemical binding]; other site 272630010788 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 272630010789 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 272630010790 RNase E interface [polypeptide binding]; other site 272630010791 trimer interface [polypeptide binding]; other site 272630010792 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 272630010793 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 272630010794 RNase E interface [polypeptide binding]; other site 272630010795 trimer interface [polypeptide binding]; other site 272630010796 active site 272630010797 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 272630010798 putative nucleic acid binding region [nucleotide binding]; other site 272630010799 G-X-X-G motif; other site 272630010800 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 272630010801 RNA binding site [nucleotide binding]; other site 272630010802 domain interface; other site 272630010803 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272630010804 16S/18S rRNA binding site [nucleotide binding]; other site 272630010805 S13e-L30e interaction site [polypeptide binding]; other site 272630010806 25S rRNA binding site [nucleotide binding]; other site 272630010807 amino acid transporter; Region: 2A0306; TIGR00909 272630010808 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 272630010809 putative catalytic site [active] 272630010810 putative phosphate binding site [ion binding]; other site 272630010811 active site 272630010812 metal binding site A [ion binding]; metal-binding site 272630010813 DNA binding site [nucleotide binding] 272630010814 putative AP binding site [nucleotide binding]; other site 272630010815 putative metal binding site B [ion binding]; other site 272630010816 Sensors of blue-light using FAD; Region: BLUF; pfam04940 272630010817 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630010818 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630010819 metal binding site [ion binding]; metal-binding site 272630010820 active site 272630010821 I-site; other site 272630010822 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630010823 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 272630010824 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 272630010825 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 272630010826 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272630010827 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 272630010828 NAD synthetase; Reviewed; Region: nadE; PRK02628 272630010829 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 272630010830 multimer interface [polypeptide binding]; other site 272630010831 active site 272630010832 catalytic triad [active] 272630010833 protein interface 1 [polypeptide binding]; other site 272630010834 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272630010835 homodimer interface [polypeptide binding]; other site 272630010836 NAD binding pocket [chemical binding]; other site 272630010837 ATP binding pocket [chemical binding]; other site 272630010838 Mg binding site [ion binding]; other site 272630010839 active-site loop [active] 272630010840 response regulator; Provisional; Region: PRK13435 272630010841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630010842 active site 272630010843 phosphorylation site [posttranslational modification] 272630010844 intermolecular recognition site; other site 272630010845 dimerization interface [polypeptide binding]; other site 272630010846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630010847 PAS domain; Region: PAS_9; pfam13426 272630010848 putative active site [active] 272630010849 heme pocket [chemical binding]; other site 272630010850 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630010851 Histidine kinase; Region: HisKA_2; pfam07568 272630010852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630010853 ATP binding site [chemical binding]; other site 272630010854 Mg2+ binding site [ion binding]; other site 272630010855 G-X-G motif; other site 272630010856 muropeptide transporter; Validated; Region: ampG; cl17669 272630010857 EcsC protein family; Region: EcsC; pfam12787 272630010858 NnrU protein; Region: NnrU; pfam07298 272630010859 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 272630010860 GTP-binding protein Der; Reviewed; Region: PRK00093 272630010861 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272630010862 G1 box; other site 272630010863 GTP/Mg2+ binding site [chemical binding]; other site 272630010864 Switch I region; other site 272630010865 G2 box; other site 272630010866 Switch II region; other site 272630010867 G3 box; other site 272630010868 G4 box; other site 272630010869 G5 box; other site 272630010870 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272630010871 G1 box; other site 272630010872 GTP/Mg2+ binding site [chemical binding]; other site 272630010873 Switch I region; other site 272630010874 G2 box; other site 272630010875 G3 box; other site 272630010876 Switch II region; other site 272630010877 G4 box; other site 272630010878 G5 box; other site 272630010879 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272630010880 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 272630010881 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 272630010882 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 272630010883 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272630010884 DNA binding site [nucleotide binding] 272630010885 catalytic residue [active] 272630010886 H2TH interface [polypeptide binding]; other site 272630010887 putative catalytic residues [active] 272630010888 turnover-facilitating residue; other site 272630010889 intercalation triad [nucleotide binding]; other site 272630010890 8OG recognition residue [nucleotide binding]; other site 272630010891 putative reading head residues; other site 272630010892 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272630010893 Predicted transcriptional regulator [Transcription]; Region: COG1959 272630010894 Transcriptional regulator; Region: Rrf2; pfam02082 272630010895 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 272630010896 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 272630010897 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272630010898 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272630010899 Beta-lactamase; Region: Beta-lactamase; pfam00144 272630010900 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 272630010901 PAS fold; Region: PAS_4; pfam08448 272630010902 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272630010903 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630010904 putative active site [active] 272630010905 heme pocket [chemical binding]; other site 272630010906 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630010907 dimer interface [polypeptide binding]; other site 272630010908 phosphorylation site [posttranslational modification] 272630010909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630010910 ATP binding site [chemical binding]; other site 272630010911 Mg2+ binding site [ion binding]; other site 272630010912 G-X-G motif; other site 272630010913 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630010914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630010915 active site 272630010916 phosphorylation site [posttranslational modification] 272630010917 intermolecular recognition site; other site 272630010918 dimerization interface [polypeptide binding]; other site 272630010919 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 272630010920 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272630010921 GSH binding site (G-site) [chemical binding]; other site 272630010922 C-terminal domain interface [polypeptide binding]; other site 272630010923 dimer interface [polypeptide binding]; other site 272630010924 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 272630010925 dimer interface [polypeptide binding]; other site 272630010926 N-terminal domain interface [polypeptide binding]; other site 272630010927 substrate binding pocket (H-site) [chemical binding]; other site 272630010928 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 272630010929 excinuclease ABC subunit B; Provisional; Region: PRK05298 272630010930 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272630010931 ATP binding site [chemical binding]; other site 272630010932 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630010933 nucleotide binding region [chemical binding]; other site 272630010934 ATP-binding site [chemical binding]; other site 272630010935 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272630010936 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630010937 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630010938 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272630010939 putative effector binding pocket; other site 272630010940 dimerization interface [polypeptide binding]; other site 272630010941 Predicted membrane protein [Function unknown]; Region: COG2259 272630010942 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 272630010943 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272630010944 putative metal binding site [ion binding]; other site 272630010945 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 272630010946 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14839 272630010947 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 272630010948 catalytic residue [active] 272630010949 putative FPP diphosphate binding site; other site 272630010950 putative FPP binding hydrophobic cleft; other site 272630010951 dimer interface [polypeptide binding]; other site 272630010952 putative IPP diphosphate binding site; other site 272630010953 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 272630010954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630010955 FeS/SAM binding site; other site 272630010956 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 272630010957 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272630010958 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272630010959 glycerol kinase; Provisional; Region: glpK; PRK00047 272630010960 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 272630010961 N- and C-terminal domain interface [polypeptide binding]; other site 272630010962 active site 272630010963 MgATP binding site [chemical binding]; other site 272630010964 catalytic site [active] 272630010965 metal binding site [ion binding]; metal-binding site 272630010966 putative homotetramer interface [polypeptide binding]; other site 272630010967 glycerol binding site [chemical binding]; other site 272630010968 homodimer interface [polypeptide binding]; other site 272630010969 hypothetical protein; Provisional; Region: PRK06489 272630010970 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 272630010971 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 272630010972 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630010973 dimer interface [polypeptide binding]; other site 272630010974 putative CheW interface [polypeptide binding]; other site 272630010975 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 272630010976 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272630010977 active site 272630010978 catalytic site [active] 272630010979 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 272630010980 homotrimer interaction site [polypeptide binding]; other site 272630010981 putative active site [active] 272630010982 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 272630010983 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 272630010984 putative active site [active] 272630010985 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272630010986 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 272630010987 Walker A/P-loop; other site 272630010988 ATP binding site [chemical binding]; other site 272630010989 Q-loop/lid; other site 272630010990 ABC transporter signature motif; other site 272630010991 Walker B; other site 272630010992 D-loop; other site 272630010993 H-loop/switch region; other site 272630010994 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272630010995 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 272630010996 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630010997 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272630010998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272630010999 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 272630011000 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272630011001 inhibitor-cofactor binding pocket; inhibition site 272630011002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630011003 catalytic residue [active] 272630011004 ornithine carbamoyltransferase; Provisional; Region: PRK00779 272630011005 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272630011006 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272630011007 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 272630011008 putative hydrophobic ligand binding site [chemical binding]; other site 272630011009 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 272630011010 putative dimer interface [polypeptide binding]; other site 272630011011 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272630011012 short chain dehydrogenase; Provisional; Region: PRK06523 272630011013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630011014 NAD(P) binding site [chemical binding]; other site 272630011015 active site 272630011016 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 272630011017 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272630011018 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272630011019 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272630011020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630011021 putative active site [active] 272630011022 heme pocket [chemical binding]; other site 272630011023 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 272630011024 GAF domain; Region: GAF; pfam01590 272630011025 Phytochrome region; Region: PHY; pfam00360 272630011026 Histidine kinase; Region: HisKA_2; pfam07568 272630011027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630011028 ATP binding site [chemical binding]; other site 272630011029 Mg2+ binding site [ion binding]; other site 272630011030 G-X-G motif; other site 272630011031 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 272630011032 heme binding pocket [chemical binding]; other site 272630011033 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 272630011034 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 272630011035 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 272630011036 PAP2 superfamily; Region: PAP2_3; pfam14378 272630011037 active site 272630011038 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272630011039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630011040 Walker A motif; other site 272630011041 ATP binding site [chemical binding]; other site 272630011042 Walker B motif; other site 272630011043 arginine finger; other site 272630011044 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272630011045 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 272630011046 flagellar assembly protein H; Validated; Region: fliH; PRK06032 272630011047 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 272630011048 FliG C-terminal domain; Region: FliG_C; pfam01706 272630011049 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 272630011050 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 272630011051 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 272630011052 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 272630011053 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 272630011054 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 272630011055 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 272630011056 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 272630011057 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272630011058 Ligand Binding Site [chemical binding]; other site 272630011059 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272630011060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630011061 S-adenosylmethionine binding site [chemical binding]; other site 272630011062 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272630011063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630011064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630011065 ATP binding site [chemical binding]; other site 272630011066 Mg2+ binding site [ion binding]; other site 272630011067 G-X-G motif; other site 272630011068 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 272630011069 active site clefts [active] 272630011070 zinc binding site [ion binding]; other site 272630011071 dimer interface [polypeptide binding]; other site 272630011072 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272630011073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630011074 putative substrate translocation pore; other site 272630011075 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 272630011076 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272630011077 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630011078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272630011079 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272630011080 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 272630011081 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 272630011082 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 272630011083 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272630011084 active site 272630011085 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 272630011086 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 272630011087 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 272630011088 PAS domain; Region: PAS; smart00091 272630011089 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630011090 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630011091 dimer interface [polypeptide binding]; other site 272630011092 phosphorylation site [posttranslational modification] 272630011093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630011094 ATP binding site [chemical binding]; other site 272630011095 Mg2+ binding site [ion binding]; other site 272630011096 G-X-G motif; other site 272630011097 Response regulator receiver domain; Region: Response_reg; pfam00072 272630011098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630011099 active site 272630011100 phosphorylation site [posttranslational modification] 272630011101 intermolecular recognition site; other site 272630011102 dimerization interface [polypeptide binding]; other site 272630011103 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 272630011104 tetramer interface [polypeptide binding]; other site 272630011105 dimer interface [polypeptide binding]; other site 272630011106 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 272630011107 tetramer interface [polypeptide binding]; other site 272630011108 dimer interface [polypeptide binding]; other site 272630011109 circadian clock protein KaiC; Reviewed; Region: PRK09302 272630011110 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272630011111 Walker A motif; other site 272630011112 ATP binding site [chemical binding]; other site 272630011113 Walker B motif; other site 272630011114 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272630011115 Walker A motif; other site 272630011116 ATP binding site [chemical binding]; other site 272630011117 Walker B motif; other site 272630011118 Response regulator receiver domain; Region: Response_reg; pfam00072 272630011119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630011120 active site 272630011121 phosphorylation site [posttranslational modification] 272630011122 intermolecular recognition site; other site 272630011123 dimerization interface [polypeptide binding]; other site 272630011124 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630011125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630011126 ATP binding site [chemical binding]; other site 272630011127 Mg2+ binding site [ion binding]; other site 272630011128 G-X-G motif; other site 272630011129 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272630011130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630011131 active site 272630011132 phosphorylation site [posttranslational modification] 272630011133 intermolecular recognition site; other site 272630011134 dimerization interface [polypeptide binding]; other site 272630011135 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630011136 DNA binding site [nucleotide binding] 272630011137 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272630011138 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 272630011139 Staphylococcal nuclease homologues; Region: SNc; smart00318 272630011140 Catalytic site; other site 272630011141 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 272630011142 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 272630011143 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 272630011144 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 272630011145 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 272630011146 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272630011147 N-terminal plug; other site 272630011148 ligand-binding site [chemical binding]; other site 272630011149 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 272630011150 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 272630011151 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 272630011152 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 272630011153 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 272630011154 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272630011155 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 272630011156 active site 272630011157 substrate binding site [chemical binding]; other site 272630011158 metal binding site [ion binding]; metal-binding site 272630011159 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 272630011160 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272630011161 Right handed beta helix region; Region: Beta_helix; pfam13229 272630011162 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 272630011163 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 272630011164 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 272630011165 Bacterial sugar transferase; Region: Bac_transf; pfam02397 272630011166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630011167 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272630011168 NAD(P) binding site [chemical binding]; other site 272630011169 active site 272630011170 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 272630011171 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 272630011172 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 272630011173 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272630011174 NAD binding site [chemical binding]; other site 272630011175 putative substrate binding site 2 [chemical binding]; other site 272630011176 putative substrate binding site 1 [chemical binding]; other site 272630011177 active site 272630011178 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 272630011179 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 272630011180 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 272630011181 Substrate binding site; other site 272630011182 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 272630011183 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272630011184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630011185 active site 272630011186 phosphorylation site [posttranslational modification] 272630011187 intermolecular recognition site; other site 272630011188 dimerization interface [polypeptide binding]; other site 272630011189 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630011190 DNA binding residues [nucleotide binding] 272630011191 dimerization interface [polypeptide binding]; other site 272630011192 Uncharacterized conserved protein [Function unknown]; Region: COG3391 272630011193 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272630011194 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272630011195 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272630011196 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272630011197 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 272630011198 putative hydrophobic ligand binding site [chemical binding]; other site 272630011199 protein interface [polypeptide binding]; other site 272630011200 gate; other site 272630011201 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 272630011202 metal ion-dependent adhesion site (MIDAS); other site 272630011203 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 272630011204 metal ion-dependent adhesion site (MIDAS); other site 272630011205 Protein of unknown function DUF58; Region: DUF58; pfam01882 272630011206 MoxR-like ATPases [General function prediction only]; Region: COG0714 272630011207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630011208 Walker A motif; other site 272630011209 ATP binding site [chemical binding]; other site 272630011210 Walker B motif; other site 272630011211 arginine finger; other site 272630011212 Methanol dehydrogenase beta subunit; Region: MDH; pfam02315 272630011213 cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872 272630011214 methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870 272630011215 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272630011216 substrate binding pocket [chemical binding]; other site 272630011217 membrane-bound complex binding site; other site 272630011218 hinge residues; other site 272630011219 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 272630011220 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 272630011221 Trp docking motif [polypeptide binding]; other site 272630011222 dimer interface [polypeptide binding]; other site 272630011223 active site 272630011224 small subunit binding site [polypeptide binding]; other site 272630011225 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272630011226 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 272630011227 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272630011228 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 272630011229 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 272630011230 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 272630011231 Substrate binding site; other site 272630011232 Mg++ binding site; other site 272630011233 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272630011234 putative trimer interface [polypeptide binding]; other site 272630011235 putative CoA binding site [chemical binding]; other site 272630011236 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 272630011237 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 272630011238 glutaminase active site [active] 272630011239 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272630011240 dimer interface [polypeptide binding]; other site 272630011241 active site 272630011242 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272630011243 dimer interface [polypeptide binding]; other site 272630011244 active site 272630011245 Domain of unknown function (DUF336); Region: DUF336; pfam03928 272630011246 Uncharacterized conserved protein [Function unknown]; Region: COG2928 272630011247 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 272630011248 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 272630011249 generic binding surface II; other site 272630011250 ssDNA binding site; other site 272630011251 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272630011252 ATP binding site [chemical binding]; other site 272630011253 putative Mg++ binding site [ion binding]; other site 272630011254 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630011255 nucleotide binding region [chemical binding]; other site 272630011256 ATP-binding site [chemical binding]; other site 272630011257 Uncharacterized conserved protein [Function unknown]; Region: COG2938 272630011258 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 272630011259 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 272630011260 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272630011261 ATP binding site [chemical binding]; other site 272630011262 putative Mg++ binding site [ion binding]; other site 272630011263 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630011264 nucleotide binding region [chemical binding]; other site 272630011265 ATP-binding site [chemical binding]; other site 272630011266 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 272630011267 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272630011268 DNA-binding site [nucleotide binding]; DNA binding site 272630011269 RNA-binding motif; other site 272630011270 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 272630011271 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272630011272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 272630011273 dimer interface [polypeptide binding]; other site 272630011274 phosphorylation site [posttranslational modification] 272630011275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630011276 ATP binding site [chemical binding]; other site 272630011277 Mg2+ binding site [ion binding]; other site 272630011278 G-X-G motif; other site 272630011279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630011280 active site 272630011281 phosphorylation site [posttranslational modification] 272630011282 intermolecular recognition site; other site 272630011283 acyl-CoA synthetase; Validated; Region: PRK08162 272630011284 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 272630011285 acyl-activating enzyme (AAE) consensus motif; other site 272630011286 putative active site [active] 272630011287 AMP binding site [chemical binding]; other site 272630011288 putative CoA binding site [chemical binding]; other site 272630011289 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 272630011290 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272630011291 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 272630011292 Ligand binding site; other site 272630011293 Putative Catalytic site; other site 272630011294 DXD motif; other site 272630011295 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 272630011296 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 272630011297 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 272630011298 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 272630011299 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 272630011300 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 272630011301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630011302 NAD(P) binding site [chemical binding]; other site 272630011303 active site 272630011304 hypothetical protein; Validated; Region: PRK00029 272630011305 Uncharacterized conserved protein [Function unknown]; Region: COG0397 272630011306 EamA-like transporter family; Region: EamA; pfam00892 272630011307 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 272630011308 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630011309 Histidine kinase; Region: HisKA_2; pfam07568 272630011310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630011311 ATP binding site [chemical binding]; other site 272630011312 Mg2+ binding site [ion binding]; other site 272630011313 G-X-G motif; other site 272630011314 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 272630011315 active site 272630011316 oxyanion hole [active] 272630011317 catalytic triad [active] 272630011318 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 272630011319 heme-binding site [chemical binding]; other site 272630011320 putative hydrolase; Provisional; Region: PRK02113 272630011321 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 272630011322 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272630011323 active site 272630011324 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 272630011325 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272630011326 active site 272630011327 HIGH motif; other site 272630011328 KMSKS motif; other site 272630011329 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272630011330 tRNA binding surface [nucleotide binding]; other site 272630011331 anticodon binding site; other site 272630011332 DNA polymerase III subunit delta'; Validated; Region: PRK07471 272630011333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272630011334 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272630011335 thymidylate kinase; Validated; Region: tmk; PRK00698 272630011336 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272630011337 TMP-binding site; other site 272630011338 ATP-binding site [chemical binding]; other site 272630011339 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272630011340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630011341 dimer interface [polypeptide binding]; other site 272630011342 conserved gate region; other site 272630011343 putative PBP binding loops; other site 272630011344 ABC-ATPase subunit interface; other site 272630011345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272630011346 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272630011347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630011348 Walker A/P-loop; other site 272630011349 ATP binding site [chemical binding]; other site 272630011350 Q-loop/lid; other site 272630011351 ABC transporter signature motif; other site 272630011352 Walker B; other site 272630011353 D-loop; other site 272630011354 H-loop/switch region; other site 272630011355 TOBE domain; Region: TOBE_2; pfam08402 272630011356 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272630011357 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 272630011358 ligand binding site [chemical binding]; other site 272630011359 flexible hinge region; other site 272630011360 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 272630011361 Predicted membrane protein [Function unknown]; Region: COG5373 272630011362 Predicted membrane protein [Function unknown]; Region: COG5373 272630011363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630011364 D-galactonate transporter; Region: 2A0114; TIGR00893 272630011365 putative substrate translocation pore; other site 272630011366 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 272630011367 homodimer interface [polypeptide binding]; other site 272630011368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630011369 catalytic residue [active] 272630011370 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272630011371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272630011372 DNA-binding site [nucleotide binding]; DNA binding site 272630011373 FCD domain; Region: FCD; pfam07729 272630011374 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 272630011375 short chain dehydrogenase; Provisional; Region: PRK06701 272630011376 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 272630011377 NAD binding site [chemical binding]; other site 272630011378 metal binding site [ion binding]; metal-binding site 272630011379 active site 272630011380 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272630011381 FAD binding domain; Region: FAD_binding_4; pfam01565 272630011382 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 272630011383 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 272630011384 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 272630011385 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272630011386 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 272630011387 tetramerization interface [polypeptide binding]; other site 272630011388 NAD(P) binding site [chemical binding]; other site 272630011389 catalytic residues [active] 272630011390 Hint domain; Region: Hint_2; pfam13403 272630011391 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 272630011392 Chain length determinant protein; Region: Wzz; pfam02706 272630011393 O-Antigen ligase; Region: Wzy_C; pfam04932 272630011394 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 272630011395 lipoate-protein ligase B; Provisional; Region: PRK14341 272630011396 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272630011397 active site 272630011398 Protein of unknown function, DUF606; Region: DUF606; pfam04657 272630011399 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272630011400 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272630011401 Response regulator receiver domain; Region: Response_reg; pfam00072 272630011402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630011403 active site 272630011404 phosphorylation site [posttranslational modification] 272630011405 intermolecular recognition site; other site 272630011406 dimerization interface [polypeptide binding]; other site 272630011407 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272630011408 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272630011409 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272630011410 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272630011411 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272630011412 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272630011413 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630011414 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272630011415 putative active site [active] 272630011416 heme pocket [chemical binding]; other site 272630011417 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630011418 putative active site [active] 272630011419 heme pocket [chemical binding]; other site 272630011420 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630011421 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630011422 dimer interface [polypeptide binding]; other site 272630011423 phosphorylation site [posttranslational modification] 272630011424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630011425 ATP binding site [chemical binding]; other site 272630011426 Mg2+ binding site [ion binding]; other site 272630011427 G-X-G motif; other site 272630011428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630011429 active site 272630011430 phosphorylation site [posttranslational modification] 272630011431 intermolecular recognition site; other site 272630011432 dimerization interface [polypeptide binding]; other site 272630011433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630011434 active site 272630011435 phosphorylation site [posttranslational modification] 272630011436 intermolecular recognition site; other site 272630011437 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272630011438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272630011439 DNA-binding site [nucleotide binding]; DNA binding site 272630011440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272630011441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630011442 homodimer interface [polypeptide binding]; other site 272630011443 catalytic residue [active] 272630011444 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272630011445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630011446 active site 272630011447 phosphorylation site [posttranslational modification] 272630011448 intermolecular recognition site; other site 272630011449 dimerization interface [polypeptide binding]; other site 272630011450 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630011451 DNA binding residues [nucleotide binding] 272630011452 dimerization interface [polypeptide binding]; other site 272630011453 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272630011454 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272630011455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 272630011456 L-lactate permease; Region: Lactate_perm; cl00701 272630011457 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 272630011458 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 272630011459 dimanganese center [ion binding]; other site 272630011460 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 272630011461 substrate binding pocket [chemical binding]; other site 272630011462 substrate-Mg2+ binding site; other site 272630011463 aspartate-rich region 2; other site 272630011464 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 272630011465 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 272630011466 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 272630011467 Protein export membrane protein; Region: SecD_SecF; pfam02355 272630011468 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 272630011469 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 272630011470 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 272630011471 Preprotein translocase subunit; Region: YajC; pfam02699 272630011472 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 272630011473 Protein of unknown function (DUF815); Region: DUF815; pfam05673 272630011474 Walker A motif; other site 272630011475 ATP binding site [chemical binding]; other site 272630011476 Walker B motif; other site 272630011477 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272630011478 Peptidase family M23; Region: Peptidase_M23; pfam01551 272630011479 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 272630011480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272630011481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630011482 S-adenosylmethionine binding site [chemical binding]; other site 272630011483 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 272630011484 seryl-tRNA synthetase; Provisional; Region: PRK05431 272630011485 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272630011486 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272630011487 dimer interface [polypeptide binding]; other site 272630011488 active site 272630011489 motif 1; other site 272630011490 motif 2; other site 272630011491 motif 3; other site 272630011492 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 272630011493 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 272630011494 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272630011495 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 272630011496 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 272630011497 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272630011498 substrate binding site [chemical binding]; other site 272630011499 oxyanion hole (OAH) forming residues; other site 272630011500 trimer interface [polypeptide binding]; other site 272630011501 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 272630011502 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 272630011503 dimer interface [polypeptide binding]; other site 272630011504 allosteric magnesium binding site [ion binding]; other site 272630011505 active site 272630011506 aspartate-rich active site metal binding site; other site 272630011507 Schiff base residues; other site 272630011508 RDD family; Region: RDD; pfam06271 272630011509 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 272630011510 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 272630011511 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 272630011512 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 272630011513 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 272630011514 maltose O-acetyltransferase; Provisional; Region: PRK10092 272630011515 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 272630011516 active site 272630011517 substrate binding site [chemical binding]; other site 272630011518 trimer interface [polypeptide binding]; other site 272630011519 CoA binding site [chemical binding]; other site 272630011520 Predicted metalloprotease [General function prediction only]; Region: COG2321 272630011521 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 272630011522 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 272630011523 Fe-S cluster binding site [ion binding]; other site 272630011524 active site 272630011525 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 272630011526 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 272630011527 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 272630011528 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 272630011529 putative active site pocket [active] 272630011530 cleavage site 272630011531 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 272630011532 Predicted permeases [General function prediction only]; Region: RarD; COG2962 272630011533 Ribosome modulation factor; Region: RMF; cl01207 272630011534 cystathionine beta-lyase; Provisional; Region: PRK05967 272630011535 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272630011536 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272630011537 catalytic residue [active] 272630011538 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 272630011539 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272630011540 NAD binding site [chemical binding]; other site 272630011541 catalytic Zn binding site [ion binding]; other site 272630011542 structural Zn binding site [ion binding]; other site 272630011543 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 272630011544 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 272630011545 PAS fold; Region: PAS_4; pfam08448 272630011546 PAS domain; Region: PAS; smart00091 272630011547 PAS fold; Region: PAS_4; pfam08448 272630011548 PAS domain S-box; Region: sensory_box; TIGR00229 272630011549 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630011550 putative active site [active] 272630011551 heme pocket [chemical binding]; other site 272630011552 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272630011553 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630011554 putative active site [active] 272630011555 heme pocket [chemical binding]; other site 272630011556 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272630011557 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630011558 putative active site [active] 272630011559 heme pocket [chemical binding]; other site 272630011560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630011561 dimer interface [polypeptide binding]; other site 272630011562 phosphorylation site [posttranslational modification] 272630011563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630011564 ATP binding site [chemical binding]; other site 272630011565 Mg2+ binding site [ion binding]; other site 272630011566 G-X-G motif; other site 272630011567 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630011568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630011569 active site 272630011570 phosphorylation site [posttranslational modification] 272630011571 intermolecular recognition site; other site 272630011572 dimerization interface [polypeptide binding]; other site 272630011573 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272630011574 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 272630011575 Probable Catalytic site; other site 272630011576 metal-binding site 272630011577 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272630011578 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272630011579 Probable Catalytic site; other site 272630011580 metal-binding site 272630011581 Cupin domain; Region: Cupin_2; cl17218 272630011582 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 272630011583 Methyltransferase domain; Region: Methyltransf_18; pfam12847 272630011584 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272630011585 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 272630011586 putative dimer interface [polypeptide binding]; other site 272630011587 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 272630011588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630011589 ATP binding site [chemical binding]; other site 272630011590 Mg2+ binding site [ion binding]; other site 272630011591 G-X-G motif; other site 272630011592 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 272630011593 ATP binding site [chemical binding]; other site 272630011594 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 272630011595 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272630011596 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272630011597 active site 272630011598 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272630011599 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272630011600 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272630011601 ABC transporter; Region: ABC_tran_2; pfam12848 272630011602 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272630011603 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272630011604 RibD C-terminal domain; Region: RibD_C; cl17279 272630011605 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 272630011606 OsmC-like protein; Region: OsmC; cl00767 272630011607 Domain of unknown function (DUF336); Region: DUF336; cl01249 272630011608 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272630011609 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272630011610 peptide binding site [polypeptide binding]; other site 272630011611 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 272630011612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630011613 dimer interface [polypeptide binding]; other site 272630011614 conserved gate region; other site 272630011615 putative PBP binding loops; other site 272630011616 ABC-ATPase subunit interface; other site 272630011617 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272630011618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630011619 ABC-ATPase subunit interface; other site 272630011620 benzoate transport; Region: 2A0115; TIGR00895 272630011621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630011622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630011623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 272630011624 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630011625 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630011626 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272630011627 dimerization interface [polypeptide binding]; other site 272630011628 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 272630011629 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272630011630 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 272630011631 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 272630011632 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 272630011633 DsbD alpha interface [polypeptide binding]; other site 272630011634 catalytic residues [active] 272630011635 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 272630011636 MutS domain I; Region: MutS_I; pfam01624 272630011637 MutS domain II; Region: MutS_II; pfam05188 272630011638 MutS domain III; Region: MutS_III; pfam05192 272630011639 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 272630011640 Walker A/P-loop; other site 272630011641 ATP binding site [chemical binding]; other site 272630011642 Q-loop/lid; other site 272630011643 ABC transporter signature motif; other site 272630011644 Walker B; other site 272630011645 D-loop; other site 272630011646 H-loop/switch region; other site 272630011647 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 272630011648 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272630011649 ATP binding site [chemical binding]; other site 272630011650 putative Mg++ binding site [ion binding]; other site 272630011651 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630011652 nucleotide binding region [chemical binding]; other site 272630011653 ATP-binding site [chemical binding]; other site 272630011654 Helicase associated domain (HA2); Region: HA2; cl04503 272630011655 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 272630011656 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272630011657 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 272630011658 active site 272630011659 dimer interface [polypeptide binding]; other site 272630011660 metal binding site [ion binding]; metal-binding site 272630011661 glutathione binding site [chemical binding]; other site 272630011662 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 272630011663 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272630011664 active site 272630011665 DNA binding site [nucleotide binding] 272630011666 Int/Topo IB signature motif; other site 272630011667 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272630011668 catalytic core [active] 272630011669 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 272630011670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 272630011671 MOSC domain; Region: MOSC; pfam03473 272630011672 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 272630011673 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 272630011674 NAD binding site [chemical binding]; other site 272630011675 homotetramer interface [polypeptide binding]; other site 272630011676 homodimer interface [polypeptide binding]; other site 272630011677 substrate binding site [chemical binding]; other site 272630011678 active site 272630011679 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272630011680 HSP70 interaction site [polypeptide binding]; other site 272630011681 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272630011682 substrate binding site [polypeptide binding]; other site 272630011683 dimer interface [polypeptide binding]; other site 272630011684 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 272630011685 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 272630011686 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 272630011687 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 272630011688 Response regulator receiver domain; Region: Response_reg; pfam00072 272630011689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630011690 active site 272630011691 phosphorylation site [posttranslational modification] 272630011692 intermolecular recognition site; other site 272630011693 dimerization interface [polypeptide binding]; other site 272630011694 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 272630011695 classical (c) SDRs; Region: SDR_c; cd05233 272630011696 NAD(P) binding site [chemical binding]; other site 272630011697 active site 272630011698 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 272630011699 nudix motif; other site 272630011700 Protein of unknown function (DUF2385); Region: DUF2385; pfam09539 272630011701 dihydroorotase; Validated; Region: PRK09060 272630011702 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272630011703 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 272630011704 active site 272630011705 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 272630011706 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 272630011707 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272630011708 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 272630011709 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 272630011710 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 272630011711 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 272630011712 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 272630011713 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272630011714 TPP-binding site; other site 272630011715 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272630011716 PYR/PP interface [polypeptide binding]; other site 272630011717 dimer interface [polypeptide binding]; other site 272630011718 TPP binding site [chemical binding]; other site 272630011719 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272630011720 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 272630011721 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 272630011722 E-class dimer interface [polypeptide binding]; other site 272630011723 P-class dimer interface [polypeptide binding]; other site 272630011724 active site 272630011725 Cu2+ binding site [ion binding]; other site 272630011726 Zn2+ binding site [ion binding]; other site 272630011727 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 272630011728 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272630011729 RNA binding surface [nucleotide binding]; other site 272630011730 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 272630011731 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 272630011732 Protein of unknown function (DUF563); Region: DUF563; pfam04577 272630011733 DHHW protein; Region: DHHW; pfam14286 272630011734 Uncharacterized conserved protein [Function unknown]; Region: COG2135 272630011735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 272630011736 Protein of unknown function, DUF482; Region: DUF482; pfam04339 272630011737 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272630011738 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 272630011739 metal binding site [ion binding]; metal-binding site 272630011740 putative dimer interface [polypeptide binding]; other site 272630011741 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 272630011742 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 272630011743 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272630011744 DNA binding site [nucleotide binding] 272630011745 active site 272630011746 Cation efflux family; Region: Cation_efflux; pfam01545 272630011747 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272630011748 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 272630011749 HIT family signature motif; other site 272630011750 catalytic residue [active] 272630011751 PilZ domain; Region: PilZ; pfam07238 272630011752 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 272630011753 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 272630011754 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 272630011755 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272630011756 active site 272630011757 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 272630011758 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272630011759 dimer interface [polypeptide binding]; other site 272630011760 active site 272630011761 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272630011762 dimer interface [polypeptide binding]; other site 272630011763 active site 272630011764 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 272630011765 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 272630011766 putative active site [active] 272630011767 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272630011768 putative catalytic site [active] 272630011769 putative metal binding site [ion binding]; other site 272630011770 putative phosphate binding site [ion binding]; other site 272630011771 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 272630011772 active site 272630011773 homotetramer interface [polypeptide binding]; other site 272630011774 homodimer interface [polypeptide binding]; other site 272630011775 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272630011776 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 272630011777 putative active site [active] 272630011778 catalytic site [active] 272630011779 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 272630011780 putative active site [active] 272630011781 catalytic site [active] 272630011782 Uncharacterized conserved protein [Function unknown]; Region: COG0398 272630011783 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272630011784 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 272630011785 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 272630011786 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 272630011787 Subunit I/III interface [polypeptide binding]; other site 272630011788 Subunit III/IV interface [polypeptide binding]; other site 272630011789 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 272630011790 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 272630011791 D-pathway; other site 272630011792 Putative ubiquinol binding site [chemical binding]; other site 272630011793 Low-spin heme (heme b) binding site [chemical binding]; other site 272630011794 Putative water exit pathway; other site 272630011795 Binuclear center (heme o3/CuB) [ion binding]; other site 272630011796 K-pathway; other site 272630011797 Putative proton exit pathway; other site 272630011798 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 272630011799 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 272630011800 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 272630011801 metabolite-proton symporter; Region: 2A0106; TIGR00883 272630011802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630011803 putative substrate translocation pore; other site 272630011804 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272630011805 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272630011806 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630011807 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272630011808 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272630011809 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272630011810 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272630011811 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272630011812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630011813 active site 272630011814 phosphorylation site [posttranslational modification] 272630011815 intermolecular recognition site; other site 272630011816 dimerization interface [polypeptide binding]; other site 272630011817 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630011818 DNA binding residues [nucleotide binding] 272630011819 dimerization interface [polypeptide binding]; other site 272630011820 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272630011821 Histidine kinase; Region: HisKA_3; pfam07730 272630011822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630011823 ATP binding site [chemical binding]; other site 272630011824 Mg2+ binding site [ion binding]; other site 272630011825 G-X-G motif; other site 272630011826 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272630011827 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630011828 DNA binding residues [nucleotide binding] 272630011829 dimerization interface [polypeptide binding]; other site 272630011830 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272630011831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630011832 active site 272630011833 phosphorylation site [posttranslational modification] 272630011834 intermolecular recognition site; other site 272630011835 dimerization interface [polypeptide binding]; other site 272630011836 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630011837 DNA binding residues [nucleotide binding] 272630011838 dimerization interface [polypeptide binding]; other site 272630011839 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272630011840 active site 272630011841 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272630011842 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272630011843 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272630011844 active site 272630011845 catalytic residues [active] 272630011846 DNA binding site [nucleotide binding] 272630011847 Int/Topo IB signature motif; other site 272630011848 ParB-like nuclease domain; Region: ParBc; cl02129 272630011849 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 272630011850 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 272630011851 Predicted transcriptional regulator [Transcription]; Region: COG2932 272630011852 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272630011853 Catalytic site [active] 272630011854 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272630011855 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 272630011856 putative ligand binding site [chemical binding]; other site 272630011857 putative NAD binding site [chemical binding]; other site 272630011858 catalytic site [active] 272630011859 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630011860 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630011861 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 272630011862 putative dimerization interface [polypeptide binding]; other site 272630011863 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272630011864 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 272630011865 putative ligand binding site [chemical binding]; other site 272630011866 NAD binding site [chemical binding]; other site 272630011867 catalytic site [active] 272630011868 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 272630011869 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 272630011870 substrate binding site [chemical binding]; other site 272630011871 ligand binding site [chemical binding]; other site 272630011872 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272630011873 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272630011874 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272630011875 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272630011876 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 272630011877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272630011878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272630011879 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 272630011880 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 272630011881 potential catalytic triad [active] 272630011882 conserved cys residue [active] 272630011883 Amidase; Region: Amidase; cl11426 272630011884 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 272630011885 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272630011886 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272630011887 ligand binding site [chemical binding]; other site 272630011888 flexible hinge region; other site 272630011889 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272630011890 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272630011891 Cupin; Region: Cupin_6; pfam12852 272630011892 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272630011893 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272630011894 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272630011895 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 272630011896 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272630011897 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 272630011898 conserved cys residue [active] 272630011899 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 272630011900 NMT1-like family; Region: NMT1_2; pfam13379 272630011901 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272630011902 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272630011903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630011904 dimer interface [polypeptide binding]; other site 272630011905 conserved gate region; other site 272630011906 putative PBP binding loops; other site 272630011907 ABC-ATPase subunit interface; other site 272630011908 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272630011909 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272630011910 Walker A/P-loop; other site 272630011911 ATP binding site [chemical binding]; other site 272630011912 Q-loop/lid; other site 272630011913 ABC transporter signature motif; other site 272630011914 Walker B; other site 272630011915 D-loop; other site 272630011916 H-loop/switch region; other site 272630011917 tellurite resistance protein terB; Region: terB; cd07176 272630011918 putative metal binding site [ion binding]; other site 272630011919 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 272630011920 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 272630011921 G1 box; other site 272630011922 putative GEF interaction site [polypeptide binding]; other site 272630011923 GTP/Mg2+ binding site [chemical binding]; other site 272630011924 Switch I region; other site 272630011925 G2 box; other site 272630011926 G3 box; other site 272630011927 Switch II region; other site 272630011928 G4 box; other site 272630011929 G5 box; other site 272630011930 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 272630011931 elongation factor Tu; Reviewed; Region: PRK00049 272630011932 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272630011933 G1 box; other site 272630011934 GEF interaction site [polypeptide binding]; other site 272630011935 GTP/Mg2+ binding site [chemical binding]; other site 272630011936 Switch I region; other site 272630011937 G2 box; other site 272630011938 G3 box; other site 272630011939 Switch II region; other site 272630011940 G4 box; other site 272630011941 G5 box; other site 272630011942 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272630011943 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272630011944 Antibiotic Binding Site [chemical binding]; other site 272630011945 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272630011946 RNA binding surface [nucleotide binding]; other site 272630011947 DEAD/DEAH box helicase; Region: DEAD; pfam00270 272630011948 ATP binding site [chemical binding]; other site 272630011949 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272630011950 putative Mg++ binding site [ion binding]; other site 272630011951 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630011952 nucleotide binding region [chemical binding]; other site 272630011953 ATP-binding site [chemical binding]; other site 272630011954 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 272630011955 Heme NO binding; Region: HNOB; pfam07700 272630011956 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630011957 metal binding site [ion binding]; metal-binding site 272630011958 active site 272630011959 I-site; other site 272630011960 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630011961 Glucokinase; Region: Glucokinase; cl17310 272630011962 glucokinase, proteobacterial type; Region: glk; TIGR00749 272630011963 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 272630011964 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 272630011965 Domain of unknown function (DUF427); Region: DUF427; pfam04248 272630011966 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272630011967 Beta-lactamase; Region: Beta-lactamase; pfam00144 272630011968 BCCT family transporter; Region: BCCT; pfam02028 272630011969 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 272630011970 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 272630011971 putative dimer interface [polypeptide binding]; other site 272630011972 [2Fe-2S] cluster binding site [ion binding]; other site 272630011973 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 272630011974 putative dimer interface [polypeptide binding]; other site 272630011975 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 272630011976 SLBB domain; Region: SLBB; pfam10531 272630011977 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 272630011978 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 272630011979 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272630011980 catalytic loop [active] 272630011981 iron binding site [ion binding]; other site 272630011982 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 272630011983 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 272630011984 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 272630011985 [4Fe-4S] binding site [ion binding]; other site 272630011986 molybdopterin cofactor binding site; other site 272630011987 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 272630011988 molybdopterin cofactor binding site; other site 272630011989 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 272630011990 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630011991 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630011992 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272630011993 dimerization interface [polypeptide binding]; other site 272630011994 GTPase CgtA; Reviewed; Region: obgE; PRK12299 272630011995 GTP1/OBG; Region: GTP1_OBG; pfam01018 272630011996 Obg GTPase; Region: Obg; cd01898 272630011997 G1 box; other site 272630011998 GTP/Mg2+ binding site [chemical binding]; other site 272630011999 Switch I region; other site 272630012000 G2 box; other site 272630012001 G3 box; other site 272630012002 Switch II region; other site 272630012003 G4 box; other site 272630012004 G5 box; other site 272630012005 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272630012006 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272630012007 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 272630012008 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 272630012009 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 272630012010 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 272630012011 Putative hemolysin [General function prediction only]; Region: COG3176 272630012012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630012013 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272630012014 putative substrate translocation pore; other site 272630012015 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 272630012016 nucleophile elbow; other site 272630012017 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 272630012018 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 272630012019 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 272630012020 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272630012021 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272630012022 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272630012023 active site 272630012024 metal binding site [ion binding]; metal-binding site 272630012025 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 272630012026 Na binding site [ion binding]; other site 272630012027 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 272630012028 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272630012029 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630012030 putative active site [active] 272630012031 heme pocket [chemical binding]; other site 272630012032 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630012033 dimer interface [polypeptide binding]; other site 272630012034 phosphorylation site [posttranslational modification] 272630012035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630012036 ATP binding site [chemical binding]; other site 272630012037 Mg2+ binding site [ion binding]; other site 272630012038 G-X-G motif; other site 272630012039 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630012040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630012041 active site 272630012042 phosphorylation site [posttranslational modification] 272630012043 intermolecular recognition site; other site 272630012044 dimerization interface [polypeptide binding]; other site 272630012045 tellurium resistance terB-like protein; Region: terB_like; cl11965 272630012046 metal binding site [ion binding]; metal-binding site 272630012047 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 272630012048 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 272630012049 Substrate binding site; other site 272630012050 metal-binding site 272630012051 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 272630012052 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 272630012053 Phosphotransferase enzyme family; Region: APH; pfam01636 272630012054 PAS fold; Region: PAS_7; pfam12860 272630012055 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272630012056 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630012057 dimer interface [polypeptide binding]; other site 272630012058 phosphorylation site [posttranslational modification] 272630012059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630012060 ATP binding site [chemical binding]; other site 272630012061 Mg2+ binding site [ion binding]; other site 272630012062 G-X-G motif; other site 272630012063 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 272630012064 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 272630012065 homotetramer interface [polypeptide binding]; other site 272630012066 ligand binding site [chemical binding]; other site 272630012067 catalytic site [active] 272630012068 NAD binding site [chemical binding]; other site 272630012069 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 272630012070 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272630012071 acyl-activating enzyme (AAE) consensus motif; other site 272630012072 AMP binding site [chemical binding]; other site 272630012073 active site 272630012074 CoA binding site [chemical binding]; other site 272630012075 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 272630012076 putative FMN binding site [chemical binding]; other site 272630012077 enoyl-CoA hydratase; Validated; Region: PRK08139 272630012078 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272630012079 substrate binding site [chemical binding]; other site 272630012080 oxyanion hole (OAH) forming residues; other site 272630012081 trimer interface [polypeptide binding]; other site 272630012082 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272630012083 putative catalytic site [active] 272630012084 putative metal binding site [ion binding]; other site 272630012085 putative phosphate binding site [ion binding]; other site 272630012086 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 272630012087 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 272630012088 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 272630012089 putative active site [active] 272630012090 catalytic site [active] 272630012091 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272630012092 putative active site [active] 272630012093 catalytic site [active] 272630012094 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 272630012095 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 272630012096 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 272630012097 Family description; Region: UvrD_C_2; pfam13538 272630012098 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272630012099 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 272630012100 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 272630012101 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272630012102 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272630012103 catalytic residues [active] 272630012104 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 272630012105 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272630012106 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 272630012107 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 272630012108 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 272630012109 substrate binding site [chemical binding]; other site 272630012110 active site 272630012111 catalytic residues [active] 272630012112 heterodimer interface [polypeptide binding]; other site 272630012113 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 272630012114 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 272630012115 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 272630012116 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 272630012117 putative NADH binding site [chemical binding]; other site 272630012118 putative active site [active] 272630012119 nudix motif; other site 272630012120 putative metal binding site [ion binding]; other site 272630012121 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 272630012122 nucleotide binding site/active site [active] 272630012123 HIT family signature motif; other site 272630012124 catalytic residue [active] 272630012125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 272630012126 active site 272630012127 phosphorylation site [posttranslational modification] 272630012128 intermolecular recognition site; other site 272630012129 dimerization interface [polypeptide binding]; other site 272630012130 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272630012131 Zn2+ binding site [ion binding]; other site 272630012132 Mg2+ binding site [ion binding]; other site 272630012133 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272630012134 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272630012135 ATP binding site [chemical binding]; other site 272630012136 Mg++ binding site [ion binding]; other site 272630012137 motif III; other site 272630012138 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630012139 nucleotide binding region [chemical binding]; other site 272630012140 ATP-binding site [chemical binding]; other site 272630012141 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 272630012142 RNA binding site [nucleotide binding]; other site 272630012143 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630012144 dimerization interface [polypeptide binding]; other site 272630012145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272630012146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630012147 ATP binding site [chemical binding]; other site 272630012148 G-X-G motif; other site 272630012149 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272630012150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630012151 active site 272630012152 phosphorylation site [posttranslational modification] 272630012153 intermolecular recognition site; other site 272630012154 dimerization interface [polypeptide binding]; other site 272630012155 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630012156 DNA binding residues [nucleotide binding] 272630012157 dimerization interface [polypeptide binding]; other site 272630012158 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 272630012159 amino acid transporter; Region: 2A0306; TIGR00909 272630012160 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 272630012161 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 272630012162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 272630012163 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630012164 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272630012165 Walker A/P-loop; other site 272630012166 ATP binding site [chemical binding]; other site 272630012167 Q-loop/lid; other site 272630012168 ABC transporter signature motif; other site 272630012169 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 272630012170 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 272630012171 putative active site [active] 272630012172 putative dimer interface [polypeptide binding]; other site 272630012173 RNA polymerase sigma factor; Provisional; Region: PRK12547 272630012174 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630012175 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272630012176 DNA binding residues [nucleotide binding] 272630012177 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 272630012178 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 272630012179 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 272630012180 catalytic loop [active] 272630012181 iron binding site [ion binding]; other site 272630012182 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 272630012183 putative binding surface; other site 272630012184 active site 272630012185 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 272630012186 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272630012187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630012188 non-specific DNA binding site [nucleotide binding]; other site 272630012189 salt bridge; other site 272630012190 sequence-specific DNA binding site [nucleotide binding]; other site 272630012191 Cupin domain; Region: Cupin_2; pfam07883 272630012192 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272630012193 dimer interface [polypeptide binding]; other site 272630012194 substrate binding site [chemical binding]; other site 272630012195 ATP binding site [chemical binding]; other site 272630012196 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272630012197 active site 272630012198 thiamine phosphate binding site [chemical binding]; other site 272630012199 pyrophosphate binding site [ion binding]; other site 272630012200 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 272630012201 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 272630012202 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 272630012203 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272630012204 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 272630012205 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272630012206 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 272630012207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630012208 S-adenosylmethionine binding site [chemical binding]; other site 272630012209 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272630012210 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272630012211 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272630012212 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 272630012213 active site 272630012214 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 272630012215 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 272630012216 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272630012217 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 272630012218 active site 272630012219 Fructosamine kinase; Region: Fructosamin_kin; cl17579 272630012220 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272630012221 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 272630012222 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 272630012223 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 272630012224 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 272630012225 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272630012226 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 272630012227 putative C-terminal domain interface [polypeptide binding]; other site 272630012228 putative GSH binding site (G-site) [chemical binding]; other site 272630012229 putative dimer interface [polypeptide binding]; other site 272630012230 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 272630012231 putative N-terminal domain interface [polypeptide binding]; other site 272630012232 putative dimer interface [polypeptide binding]; other site 272630012233 putative substrate binding pocket (H-site) [chemical binding]; other site 272630012234 transcriptional regulator; Provisional; Region: PRK10632 272630012235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630012236 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 272630012237 putative effector binding pocket; other site 272630012238 putative dimerization interface [polypeptide binding]; other site 272630012239 sulfite reductase; Provisional; Region: PRK06214 272630012240 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 272630012241 FAD binding pocket [chemical binding]; other site 272630012242 FAD binding motif [chemical binding]; other site 272630012243 catalytic residues [active] 272630012244 NAD binding pocket [chemical binding]; other site 272630012245 phosphate binding motif [ion binding]; other site 272630012246 beta-alpha-beta structure motif; other site 272630012247 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 272630012248 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272630012249 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272630012250 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 272630012251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272630012252 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272630012253 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272630012254 Walker A/P-loop; other site 272630012255 ATP binding site [chemical binding]; other site 272630012256 Q-loop/lid; other site 272630012257 ABC transporter signature motif; other site 272630012258 Walker B; other site 272630012259 D-loop; other site 272630012260 H-loop/switch region; other site 272630012261 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272630012262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630012263 dimer interface [polypeptide binding]; other site 272630012264 conserved gate region; other site 272630012265 putative PBP binding loops; other site 272630012266 ABC-ATPase subunit interface; other site 272630012267 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272630012268 NMT1-like family; Region: NMT1_2; pfam13379 272630012269 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272630012270 NMT1-like family; Region: NMT1_2; pfam13379 272630012271 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 272630012272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 272630012273 active site 272630012274 phosphorylation site [posttranslational modification] 272630012275 intermolecular recognition site; other site 272630012276 ANTAR domain; Region: ANTAR; pfam03861 272630012277 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 272630012278 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 272630012279 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272630012280 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272630012281 TPP-binding site [chemical binding]; other site 272630012282 dimer interface [polypeptide binding]; other site 272630012283 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272630012284 PYR/PP interface [polypeptide binding]; other site 272630012285 dimer interface [polypeptide binding]; other site 272630012286 TPP binding site [chemical binding]; other site 272630012287 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272630012288 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 272630012289 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 272630012290 putative active site [active] 272630012291 catalytic residue [active] 272630012292 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272630012293 active site 272630012294 dimer interface [polypeptide binding]; other site 272630012295 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 272630012296 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 272630012297 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272630012298 PAS domain; Region: PAS_9; pfam13426 272630012299 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630012300 putative active site [active] 272630012301 heme pocket [chemical binding]; other site 272630012302 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272630012303 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630012304 dimer interface [polypeptide binding]; other site 272630012305 putative CheW interface [polypeptide binding]; other site 272630012306 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272630012307 short chain dehydrogenase; Provisional; Region: PRK06181 272630012308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630012309 NAD(P) binding site [chemical binding]; other site 272630012310 active site 272630012311 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 272630012312 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272630012313 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272630012314 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630012315 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 272630012316 active site residue [active] 272630012317 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 272630012318 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630012319 Autoinducer synthetase; Region: Autoind_synth; cl17404 272630012320 Autoinducer binding domain; Region: Autoind_bind; pfam03472 272630012321 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630012322 DNA binding residues [nucleotide binding] 272630012323 dimerization interface [polypeptide binding]; other site 272630012324 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630012325 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630012326 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 272630012327 putative substrate binding pocket [chemical binding]; other site 272630012328 putative dimerization interface [polypeptide binding]; other site 272630012329 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 272630012330 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272630012331 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 272630012332 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 272630012333 Trp docking motif [polypeptide binding]; other site 272630012334 active site 272630012335 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272630012336 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272630012337 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630012338 Histidine kinase; Region: HisKA_2; pfam07568 272630012339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630012340 ATP binding site [chemical binding]; other site 272630012341 Mg2+ binding site [ion binding]; other site 272630012342 G-X-G motif; other site 272630012343 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 272630012344 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272630012345 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 272630012346 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272630012347 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272630012348 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 272630012349 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272630012350 catalytic loop [active] 272630012351 iron binding site [ion binding]; other site 272630012352 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 272630012353 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 272630012354 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 272630012355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630012356 NAD(P) binding site [chemical binding]; other site 272630012357 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 272630012358 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 272630012359 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272630012360 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272630012361 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272630012362 Protein of unknown function, DUF606; Region: DUF606; pfam04657 272630012363 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630012364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630012365 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272630012366 dimerization interface [polypeptide binding]; other site 272630012367 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272630012368 Enoylreductase; Region: PKS_ER; smart00829 272630012369 NAD(P) binding site [chemical binding]; other site 272630012370 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272630012371 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272630012372 PAS domain S-box; Region: sensory_box; TIGR00229 272630012373 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630012374 putative active site [active] 272630012375 heme pocket [chemical binding]; other site 272630012376 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272630012377 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272630012378 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630012379 PAS fold; Region: PAS_3; pfam08447 272630012380 putative active site [active] 272630012381 heme pocket [chemical binding]; other site 272630012382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630012383 HWE histidine kinase; Region: HWE_HK; smart00911 272630012384 response regulator; Provisional; Region: PRK13435 272630012385 Bacterial SH3 domain; Region: SH3_3; pfam08239 272630012386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630012387 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 272630012388 NAD(P) binding site [chemical binding]; other site 272630012389 active site 272630012390 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 272630012391 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272630012392 dimer interface [polypeptide binding]; other site 272630012393 active site 272630012394 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 272630012395 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 272630012396 active site 272630012397 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 272630012398 active site 2 [active] 272630012399 active site 1 [active] 272630012400 acyl carrier protein; Provisional; Region: PRK06508 272630012401 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630012402 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630012403 I-site; other site 272630012404 active site 272630012405 metal binding site [ion binding]; metal-binding site 272630012406 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272630012407 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 272630012408 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272630012409 Cupin domain; Region: Cupin_2; cl17218 272630012410 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272630012411 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 272630012412 putative dimer interface [polypeptide binding]; other site 272630012413 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 272630012414 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272630012415 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 272630012416 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 272630012417 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272630012418 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 272630012419 active site 272630012420 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272630012421 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272630012422 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 272630012423 putative active site [active] 272630012424 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 272630012425 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 272630012426 active site 272630012427 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 272630012428 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 272630012429 Domain of unknown function DUF59; Region: DUF59; pfam01883 272630012430 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 272630012431 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272630012432 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 272630012433 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 272630012434 GTP binding site; other site 272630012435 DNA gyrase subunit A; Validated; Region: PRK05560 272630012436 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272630012437 CAP-like domain; other site 272630012438 active site 272630012439 primary dimer interface [polypeptide binding]; other site 272630012440 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272630012441 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272630012442 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272630012443 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272630012444 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272630012445 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 272630012446 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 272630012447 active site 272630012448 (T/H)XGH motif; other site 272630012449 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 272630012450 active site 272630012451 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 272630012452 active site 272630012453 Response regulator receiver domain; Region: Response_reg; pfam00072 272630012454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630012455 active site 272630012456 phosphorylation site [posttranslational modification] 272630012457 intermolecular recognition site; other site 272630012458 dimerization interface [polypeptide binding]; other site 272630012459 Uncharacterized conserved protein [Function unknown]; Region: COG4544 272630012460 DNA Polymerase Y-family; Region: PolY_like; cd03468 272630012461 active site 272630012462 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 272630012463 DNA binding site [nucleotide binding] 272630012464 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 272630012465 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 272630012466 putative active site [active] 272630012467 putative PHP Thumb interface [polypeptide binding]; other site 272630012468 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272630012469 generic binding surface I; other site 272630012470 generic binding surface II; other site 272630012471 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 272630012472 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 272630012473 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 272630012474 active site 272630012475 nucleophile elbow; other site 272630012476 Patatin phospholipase; Region: DUF3734; pfam12536 272630012477 Ion channel; Region: Ion_trans_2; pfam07885 272630012478 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 272630012479 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 272630012480 putative dimer interface [polypeptide binding]; other site 272630012481 [2Fe-2S] cluster binding site [ion binding]; other site 272630012482 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 272630012483 SLBB domain; Region: SLBB; pfam10531 272630012484 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 272630012485 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272630012486 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 272630012487 catalytic loop [active] 272630012488 iron binding site [ion binding]; other site 272630012489 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 272630012490 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 272630012491 [4Fe-4S] binding site [ion binding]; other site 272630012492 molybdopterin cofactor binding site; other site 272630012493 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 272630012494 molybdopterin cofactor binding site; other site 272630012495 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 272630012496 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 272630012497 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272630012498 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 272630012499 putative active site [active] 272630012500 putative metal binding site [ion binding]; other site 272630012501 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272630012502 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630012503 Right handed beta helix region; Region: Beta_helix; pfam13229 272630012504 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 272630012505 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272630012506 classical (c) SDRs; Region: SDR_c; cd05233 272630012507 NAD(P) binding site [chemical binding]; other site 272630012508 active site 272630012509 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 272630012510 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272630012511 AMP binding site [chemical binding]; other site 272630012512 active site 272630012513 acyl-activating enzyme (AAE) consensus motif; other site 272630012514 CoA binding site [chemical binding]; other site 272630012515 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 272630012516 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 272630012517 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 272630012518 dimer interface [polypeptide binding]; other site 272630012519 active site 272630012520 motif 2; other site 272630012521 motif 3; other site 272630012522 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272630012523 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272630012524 active site 272630012525 acyl carrier protein; Provisional; Region: PRK07081 272630012526 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 272630012527 thiamine pyrophosphate protein; Validated; Region: PRK08199 272630012528 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272630012529 PYR/PP interface [polypeptide binding]; other site 272630012530 dimer interface [polypeptide binding]; other site 272630012531 TPP binding site [chemical binding]; other site 272630012532 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272630012533 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 272630012534 TPP-binding site [chemical binding]; other site 272630012535 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 272630012536 aminotransferase; Provisional; Region: PRK13356 272630012537 homodimer interface [polypeptide binding]; other site 272630012538 substrate-cofactor binding pocket; other site 272630012539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630012540 catalytic residue [active] 272630012541 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 272630012542 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 272630012543 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272630012544 homodimer interface [polypeptide binding]; other site 272630012545 substrate-cofactor binding pocket; other site 272630012546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630012547 catalytic residue [active] 272630012548 homoserine O-succinyltransferase; Provisional; Region: PRK05368 272630012549 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 272630012550 conserved cys residue [active] 272630012551 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 272630012552 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272630012553 acyl-activating enzyme (AAE) consensus motif; other site 272630012554 AMP binding site [chemical binding]; other site 272630012555 active site 272630012556 CoA binding site [chemical binding]; other site 272630012557 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 272630012558 Pectate lyase; Region: Pec_lyase_C; cl01593 272630012559 Right handed beta helix region; Region: Beta_helix; pfam13229 272630012560 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 272630012561 hypothetical protein; Provisional; Region: PRK01254 272630012562 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 272630012563 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 272630012564 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 272630012565 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 272630012566 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 272630012567 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 272630012568 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272630012569 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 272630012570 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 272630012571 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272630012572 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 272630012573 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 272630012574 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 272630012575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630012576 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 272630012577 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 272630012578 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272630012579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630012580 NAD(P) binding site [chemical binding]; other site 272630012581 active site 272630012582 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 272630012583 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 272630012584 NADP binding site [chemical binding]; other site 272630012585 active site 272630012586 putative substrate binding site [chemical binding]; other site 272630012587 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 272630012588 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 272630012589 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 272630012590 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272630012591 Condensation domain; Region: Condensation; pfam00668 272630012592 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272630012593 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 272630012594 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272630012595 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 272630012596 Condensation domain; Region: Condensation; pfam00668 272630012597 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272630012598 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 272630012599 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 272630012600 acyl-activating enzyme (AAE) consensus motif; other site 272630012601 AMP binding site [chemical binding]; other site 272630012602 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272630012603 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272630012604 catalytic core [active] 272630012605 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272630012606 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272630012607 active site 272630012608 catalytic tetrad [active] 272630012609 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272630012610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630012611 Walker A motif; other site 272630012612 ATP binding site [chemical binding]; other site 272630012613 Walker B motif; other site 272630012614 arginine finger; other site 272630012615 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272630012616 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272630012617 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 272630012618 TrkA-N domain; Region: TrkA_N; pfam02254 272630012619 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 272630012620 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 272630012621 NAD binding site [chemical binding]; other site 272630012622 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272630012623 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272630012624 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 272630012625 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 272630012626 Mg++ binding site [ion binding]; other site 272630012627 putative catalytic motif [active] 272630012628 putative substrate binding site [chemical binding]; other site 272630012629 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 272630012630 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272630012631 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272630012632 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272630012633 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 272630012634 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272630012635 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272630012636 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272630012637 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272630012638 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272630012639 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 272630012640 MraW methylase family; Region: Methyltransf_5; cl17771 272630012641 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 272630012642 Ligase N family; Region: LIGANc; smart00532 272630012643 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272630012644 nucleotide binding pocket [chemical binding]; other site 272630012645 K-X-D-G motif; other site 272630012646 catalytic site [active] 272630012647 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272630012648 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272630012649 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 272630012650 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272630012651 Dimer interface [polypeptide binding]; other site 272630012652 BRCT sequence motif; other site 272630012653 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 272630012654 putative active site [active] 272630012655 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 272630012656 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272630012657 substrate binding site [chemical binding]; other site 272630012658 ATP binding site [chemical binding]; other site 272630012659 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 272630012660 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272630012661 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 272630012662 CoA-transferase family III; Region: CoA_transf_3; pfam02515 272630012663 enoyl-CoA hydratase; Provisional; Region: PRK06144 272630012664 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272630012665 substrate binding site [chemical binding]; other site 272630012666 oxyanion hole (OAH) forming residues; other site 272630012667 trimer interface [polypeptide binding]; other site 272630012668 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272630012669 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272630012670 DNA-binding site [nucleotide binding]; DNA binding site 272630012671 FCD domain; Region: FCD; pfam07729 272630012672 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272630012673 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 272630012674 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272630012675 catalytic residue [active] 272630012676 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 272630012677 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 272630012678 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 272630012679 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 272630012680 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 272630012681 DNA polymerase III subunit chi; Validated; Region: PRK05728 272630012682 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 272630012683 Protein of unknown function (DUF1190); Region: DUF1190; pfam06693 272630012684 Predicted membrane protein [Function unknown]; Region: COG3766 272630012685 CTP synthetase; Validated; Region: pyrG; PRK05380 272630012686 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272630012687 Catalytic site [active] 272630012688 active site 272630012689 UTP binding site [chemical binding]; other site 272630012690 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272630012691 active site 272630012692 putative oxyanion hole; other site 272630012693 catalytic triad [active] 272630012694 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335 272630012695 catalytic triad [active] 272630012696 conserved cis-peptide bond; other site 272630012697 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272630012698 triosephosphate isomerase; Provisional; Region: PRK14565 272630012699 substrate binding site [chemical binding]; other site 272630012700 dimer interface [polypeptide binding]; other site 272630012701 catalytic triad [active] 272630012702 periplasmic folding chaperone; Provisional; Region: PRK10788 272630012703 SurA N-terminal domain; Region: SurA_N_3; cl07813 272630012704 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 272630012705 anthranilate synthase component I; Provisional; Region: PRK13573 272630012706 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272630012707 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272630012708 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630012709 dimerization interface [polypeptide binding]; other site 272630012710 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630012711 dimer interface [polypeptide binding]; other site 272630012712 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 272630012713 putative CheW interface [polypeptide binding]; other site 272630012714 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272630012715 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 272630012716 glutamine binding [chemical binding]; other site 272630012717 catalytic triad [active] 272630012718 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 272630012719 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272630012720 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272630012721 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 272630012722 active site 272630012723 ribulose/triose binding site [chemical binding]; other site 272630012724 phosphate binding site [ion binding]; other site 272630012725 substrate (anthranilate) binding pocket [chemical binding]; other site 272630012726 product (indole) binding pocket [chemical binding]; other site 272630012727 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 272630012728 trimer interface [polypeptide binding]; other site 272630012729 dimer interface [polypeptide binding]; other site 272630012730 putative active site [active] 272630012731 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 272630012732 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 272630012733 dimer interface [polypeptide binding]; other site 272630012734 putative functional site; other site 272630012735 putative MPT binding site; other site 272630012736 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272630012737 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 272630012738 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 272630012739 active site 272630012740 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 272630012741 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 272630012742 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 272630012743 hypothetical protein; Validated; Region: PRK00124 272630012744 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 272630012745 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 272630012746 dimer interface [polypeptide binding]; other site 272630012747 active site 272630012748 citrylCoA binding site [chemical binding]; other site 272630012749 NADH binding [chemical binding]; other site 272630012750 cationic pore residues; other site 272630012751 oxalacetate/citrate binding site [chemical binding]; other site 272630012752 coenzyme A binding site [chemical binding]; other site 272630012753 catalytic triad [active] 272630012754 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272630012755 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272630012756 active site 272630012757 HIGH motif; other site 272630012758 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272630012759 active site 272630012760 KMSKS motif; other site 272630012761 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 272630012762 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 272630012763 Competence protein; Region: Competence; pfam03772 272630012764 LexA repressor; Validated; Region: PRK00215 272630012765 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 272630012766 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272630012767 Catalytic site [active] 272630012768 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 272630012769 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 272630012770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630012771 putative substrate translocation pore; other site 272630012772 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 272630012773 tartrate dehydrogenase; Region: TTC; TIGR02089 272630012774 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 272630012775 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272630012776 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272630012777 active site 272630012778 catalytic tetrad [active] 272630012779 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 272630012780 dimerization interface [polypeptide binding]; other site 272630012781 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630012782 dimer interface [polypeptide binding]; other site 272630012783 putative CheW interface [polypeptide binding]; other site 272630012784 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 272630012785 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272630012786 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272630012787 protein binding site [polypeptide binding]; other site 272630012788 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272630012789 protein binding site [polypeptide binding]; other site 272630012790 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 272630012791 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 272630012792 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272630012793 active site 272630012794 HIGH motif; other site 272630012795 nucleotide binding site [chemical binding]; other site 272630012796 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272630012797 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272630012798 active site 272630012799 KMSKS motif; other site 272630012800 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272630012801 tRNA binding surface [nucleotide binding]; other site 272630012802 anticodon binding site; other site 272630012803 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 272630012804 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 272630012805 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 272630012806 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 272630012807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630012808 S-adenosylmethionine binding site [chemical binding]; other site 272630012809 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 272630012810 putative substrate binding site [chemical binding]; other site 272630012811 putative ATP binding site [chemical binding]; other site 272630012812 PBP superfamily domain; Region: PBP_like_2; cl17296 272630012813 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 272630012814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630012815 dimer interface [polypeptide binding]; other site 272630012816 conserved gate region; other site 272630012817 putative PBP binding loops; other site 272630012818 ABC-ATPase subunit interface; other site 272630012819 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 272630012820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630012821 dimer interface [polypeptide binding]; other site 272630012822 conserved gate region; other site 272630012823 putative PBP binding loops; other site 272630012824 ABC-ATPase subunit interface; other site 272630012825 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 272630012826 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272630012827 Walker A/P-loop; other site 272630012828 ATP binding site [chemical binding]; other site 272630012829 Q-loop/lid; other site 272630012830 ABC transporter signature motif; other site 272630012831 Walker B; other site 272630012832 D-loop; other site 272630012833 H-loop/switch region; other site 272630012834 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 272630012835 PhoU domain; Region: PhoU; pfam01895 272630012836 PhoU domain; Region: PhoU; pfam01895 272630012837 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 272630012838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630012839 active site 272630012840 phosphorylation site [posttranslational modification] 272630012841 intermolecular recognition site; other site 272630012842 dimerization interface [polypeptide binding]; other site 272630012843 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630012844 DNA binding site [nucleotide binding] 272630012845 GcrA cell cycle regulator; Region: GcrA; cl11564 272630012846 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 272630012847 DNA polymerase IV; Provisional; Region: PRK02794 272630012848 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 272630012849 active site 272630012850 DNA binding site [nucleotide binding] 272630012851 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 272630012852 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 272630012853 cobyric acid synthase; Provisional; Region: PRK00784 272630012854 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 272630012855 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 272630012856 catalytic triad [active] 272630012857 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 272630012858 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 272630012859 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272630012860 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272630012861 catalytic residue [active] 272630012862 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272630012863 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 272630012864 CsbD-like; Region: CsbD; pfam05532 272630012865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630012866 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 272630012867 NAD(P) binding site [chemical binding]; other site 272630012868 active site 272630012869 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 272630012870 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 272630012871 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 272630012872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 272630012873 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 272630012874 Transglycosylase SLT domain; Region: SLT_2; pfam13406 272630012875 murein hydrolase B; Provisional; Region: PRK10760; cl17906 272630012876 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272630012877 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272630012878 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272630012879 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272630012880 RNA binding surface [nucleotide binding]; other site 272630012881 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 272630012882 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 272630012883 FMN binding site [chemical binding]; other site 272630012884 substrate binding site [chemical binding]; other site 272630012885 putative catalytic residue [active] 272630012886 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 272630012887 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 272630012888 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 272630012889 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630012890 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630012891 metal binding site [ion binding]; metal-binding site 272630012892 active site 272630012893 I-site; other site 272630012894 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272630012895 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 272630012896 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 272630012897 Walker A/P-loop; other site 272630012898 ATP binding site [chemical binding]; other site 272630012899 Q-loop/lid; other site 272630012900 ABC transporter signature motif; other site 272630012901 Walker B; other site 272630012902 D-loop; other site 272630012903 H-loop/switch region; other site 272630012904 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272630012905 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 272630012906 Methyltransferase domain; Region: Methyltransf_24; pfam13578 272630012907 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272630012908 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272630012909 active site 272630012910 HIGH motif; other site 272630012911 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272630012912 KMSKS motif; other site 272630012913 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272630012914 tRNA binding surface [nucleotide binding]; other site 272630012915 anticodon binding site; other site 272630012916 CreA protein; Region: CreA; pfam05981 272630012917 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 272630012918 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272630012919 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272630012920 ligand binding site [chemical binding]; other site 272630012921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630012922 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272630012923 putative substrate translocation pore; other site 272630012924 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272630012925 dimer interface [polypeptide binding]; other site 272630012926 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272630012927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630012928 S-adenosylmethionine binding site [chemical binding]; other site 272630012929 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 272630012930 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272630012931 active site 272630012932 HIGH motif; other site 272630012933 nucleotide binding site [chemical binding]; other site 272630012934 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272630012935 active site 272630012936 KMSKS motif; other site 272630012937 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 272630012938 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272630012939 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630012940 Fusaric acid resistance protein family; Region: FUSC; pfam04632 272630012941 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 272630012942 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 272630012943 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 272630012944 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 272630012945 C-terminal domain interface [polypeptide binding]; other site 272630012946 GSH binding site (G-site) [chemical binding]; other site 272630012947 dimer interface [polypeptide binding]; other site 272630012948 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 272630012949 N-terminal domain interface [polypeptide binding]; other site 272630012950 putative dimer interface [polypeptide binding]; other site 272630012951 active site 272630012952 translocation protein TolB; Provisional; Region: tolB; PRK05137 272630012953 TolB amino-terminal domain; Region: TolB_N; pfam04052 272630012954 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272630012955 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272630012956 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272630012957 TolA protein; Region: tolA_full; TIGR02794 272630012958 TolR protein; Region: tolR; TIGR02801 272630012959 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 272630012960 TolQ protein; Region: tolQ; TIGR02796 272630012961 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272630012962 dimer interface [polypeptide binding]; other site 272630012963 putative CheW interface [polypeptide binding]; other site 272630012964 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272630012965 active site 272630012966 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 272630012967 potential frameshift: common BLAST hit: gi|218533108|ref|YP_002423924.1| metallophosphoesterase 272630012968 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272630012969 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 272630012970 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272630012971 active site 272630012972 metal binding site [ion binding]; metal-binding site 272630012973 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272630012974 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 272630012975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630012976 Walker A motif; other site 272630012977 ATP binding site [chemical binding]; other site 272630012978 Walker B motif; other site 272630012979 arginine finger; other site 272630012980 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272630012981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 272630012982 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272630012983 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630012984 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 272630012985 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 272630012986 dimerization interface [polypeptide binding]; other site 272630012987 DPS ferroxidase diiron center [ion binding]; other site 272630012988 ion pore; other site 272630012989 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 272630012990 CoA binding domain; Region: CoA_binding_2; pfam13380 272630012991 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 272630012992 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 272630012993 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272630012994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272630012995 Coenzyme A binding pocket [chemical binding]; other site 272630012996 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 272630012997 intersubunit interface [polypeptide binding]; other site 272630012998 active site 272630012999 Zn2+ binding site [ion binding]; other site 272630013000 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 272630013001 Restriction endonuclease; Region: Mrr_cat; pfam04471 272630013002 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 272630013003 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 272630013004 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 272630013005 Transglycosylase; Region: Transgly; pfam00912 272630013006 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272630013007 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272630013008 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272630013009 cyclase homology domain; Region: CHD; cd07302 272630013010 nucleotidyl binding site; other site 272630013011 metal binding site [ion binding]; metal-binding site 272630013012 dimer interface [polypeptide binding]; other site 272630013013 MAPEG family; Region: MAPEG; cl09190 272630013014 AAA domain; Region: AAA_31; pfam13614 272630013015 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272630013016 P-loop; other site 272630013017 Magnesium ion binding site [ion binding]; other site 272630013018 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272630013019 Magnesium ion binding site [ion binding]; other site 272630013020 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 272630013021 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272630013022 ring oligomerisation interface [polypeptide binding]; other site 272630013023 ATP/Mg binding site [chemical binding]; other site 272630013024 stacking interactions; other site 272630013025 hinge regions; other site 272630013026 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272630013027 oligomerisation interface [polypeptide binding]; other site 272630013028 mobile loop; other site 272630013029 roof hairpin; other site 272630013030 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 272630013031 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 272630013032 Cl binding site [ion binding]; other site 272630013033 oligomer interface [polypeptide binding]; other site 272630013034 MarC family integral membrane protein; Region: MarC; cl00919 272630013035 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272630013036 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 272630013037 FAD binding domain; Region: FAD_binding_4; pfam01565 272630013038 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 272630013039 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 272630013040 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 272630013041 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 272630013042 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 272630013043 Substrate binding site; other site 272630013044 Cupin domain; Region: Cupin_2; cl17218 272630013045 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 272630013046 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 272630013047 active site 272630013048 substrate binding site [chemical binding]; other site 272630013049 coenzyme B12 binding site [chemical binding]; other site 272630013050 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 272630013051 B12 binding site [chemical binding]; other site 272630013052 cobalt ligand [ion binding]; other site 272630013053 Protein of unknown function (DUF817); Region: DUF817; pfam05675 272630013054 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 272630013055 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272630013056 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272630013057 protein binding site [polypeptide binding]; other site 272630013058 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272630013059 HSP70 interaction site [polypeptide binding]; other site 272630013060 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 272630013061 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 272630013062 Sporulation related domain; Region: SPOR; pfam05036 272630013063 Uncharacterized conserved protein [Function unknown]; Region: COG2127 272630013064 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 272630013065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630013066 Walker A motif; other site 272630013067 ATP binding site [chemical binding]; other site 272630013068 Walker B motif; other site 272630013069 arginine finger; other site 272630013070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630013071 Walker A motif; other site 272630013072 ATP binding site [chemical binding]; other site 272630013073 Walker B motif; other site 272630013074 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272630013075 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 272630013076 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 272630013077 substrate-cofactor binding pocket; other site 272630013078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630013079 catalytic residue [active] 272630013080 putative photosynthetic complex assembly protein 2; Region: photo_alph_chp2; TIGR03055 272630013081 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 272630013082 diiron binding motif [ion binding]; other site 272630013083 putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054 272630013084 Bacterial PH domain; Region: DUF304; pfam03703 272630013085 photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150 272630013086 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581 272630013087 subunit C interaction residues; other site 272630013088 subunit M interaction residues [polypeptide binding]; other site 272630013089 subunit L interaction residues [polypeptide binding]; other site 272630013090 putative proton transfer pathway, P1; other site 272630013091 putative proton transfer pathway, P2; other site 272630013092 PUCC protein; Region: PUCC; pfam03209 272630013093 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 272630013094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272630013095 S-adenosylmethionine binding site [chemical binding]; other site 272630013096 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 272630013097 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 272630013098 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 272630013099 P-loop; other site 272630013100 magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405 272630013101 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 272630013102 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 272630013103 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 272630013104 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 272630013105 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 272630013106 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 272630013107 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 272630013108 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 272630013109 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 272630013110 B12 binding domain; Region: B12-binding; pfam02310 272630013111 B12 binding site [chemical binding]; other site 272630013112 transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040 272630013113 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630013114 putative active site [active] 272630013115 heme pocket [chemical binding]; other site 272630013116 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 272630013117 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272630013118 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 272630013119 UbiA prenyltransferase family; Region: UbiA; pfam01040 272630013120 PUCC protein; Region: PUCC; pfam03209 272630013121 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 272630013122 TspO/MBR family; Region: TspO_MBR; pfam03073 272630013123 Cytochrome c; Region: Cytochrom_C; pfam00034 272630013124 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272630013125 Cytochrome c; Region: Cytochrom_C; pfam00034 272630013126 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272630013127 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 272630013128 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 272630013129 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 272630013130 putative active site [active] 272630013131 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 272630013132 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272630013133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630013134 Walker A/P-loop; other site 272630013135 ATP binding site [chemical binding]; other site 272630013136 Q-loop/lid; other site 272630013137 ABC transporter signature motif; other site 272630013138 Walker B; other site 272630013139 D-loop; other site 272630013140 H-loop/switch region; other site 272630013141 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 272630013142 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 272630013143 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 272630013144 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 272630013145 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272630013146 ligand binding site [chemical binding]; other site 272630013147 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 272630013148 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 272630013149 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 272630013150 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272630013151 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272630013152 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272630013153 active site 272630013154 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 272630013155 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 272630013156 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 272630013157 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 272630013158 active site 272630013159 substrate binding site [chemical binding]; other site 272630013160 metal binding site [ion binding]; metal-binding site 272630013161 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272630013162 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 272630013163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630013164 Walker A motif; other site 272630013165 ATP binding site [chemical binding]; other site 272630013166 Walker B motif; other site 272630013167 arginine finger; other site 272630013168 Peptidase family M41; Region: Peptidase_M41; pfam01434 272630013169 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272630013170 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272630013171 Ligand Binding Site [chemical binding]; other site 272630013172 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 272630013173 Tetratricopeptide repeat; Region: TPR_6; pfam13174 272630013174 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272630013175 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272630013176 ligand binding site [chemical binding]; other site 272630013177 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630013178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630013179 active site 272630013180 phosphorylation site [posttranslational modification] 272630013181 intermolecular recognition site; other site 272630013182 dimerization interface [polypeptide binding]; other site 272630013183 GSCFA family; Region: GSCFA; pfam08885 272630013184 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 272630013185 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 272630013186 active site 272630013187 domain interfaces; other site 272630013188 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 272630013189 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 272630013190 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 272630013191 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 272630013192 putative active site [active] 272630013193 putative catalytic site [active] 272630013194 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 272630013195 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 272630013196 TM-ABC transporter signature motif; other site 272630013197 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 272630013198 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 272630013199 Walker A/P-loop; other site 272630013200 ATP binding site [chemical binding]; other site 272630013201 Q-loop/lid; other site 272630013202 ABC transporter signature motif; other site 272630013203 Walker B; other site 272630013204 D-loop; other site 272630013205 H-loop/switch region; other site 272630013206 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 272630013207 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 272630013208 Walker A/P-loop; other site 272630013209 ATP binding site [chemical binding]; other site 272630013210 Q-loop/lid; other site 272630013211 ABC transporter signature motif; other site 272630013212 Walker B; other site 272630013213 D-loop; other site 272630013214 H-loop/switch region; other site 272630013215 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 272630013216 TM-ABC transporter signature motif; other site 272630013217 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 272630013218 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 272630013219 putative ligand binding site [chemical binding]; other site 272630013220 SnoaL-like domain; Region: SnoaL_2; pfam12680 272630013221 Transcriptional regulators [Transcription]; Region: FadR; COG2186 272630013222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272630013223 DNA-binding site [nucleotide binding]; DNA binding site 272630013224 FCD domain; Region: FCD; pfam07729 272630013225 PAS fold; Region: PAS_3; pfam08447 272630013226 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 272630013227 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630013228 non-specific DNA binding site [nucleotide binding]; other site 272630013229 salt bridge; other site 272630013230 sequence-specific DNA binding site [nucleotide binding]; other site 272630013231 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 272630013232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272630013233 putative substrate translocation pore; other site 272630013234 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 272630013235 dimerization interface [polypeptide binding]; other site 272630013236 metal binding site [ion binding]; metal-binding site 272630013237 hypothetical protein; Validated; Region: PRK00029 272630013238 Uncharacterized conserved protein [Function unknown]; Region: COG0397 272630013239 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 272630013240 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272630013241 PYR/PP interface [polypeptide binding]; other site 272630013242 dimer interface [polypeptide binding]; other site 272630013243 TPP binding site [chemical binding]; other site 272630013244 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272630013245 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 272630013246 TPP-binding site [chemical binding]; other site 272630013247 dimer interface [polypeptide binding]; other site 272630013248 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272630013249 Methyltransferase domain; Region: Methyltransf_12; pfam08242 272630013250 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 272630013251 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 272630013252 putative valine binding site [chemical binding]; other site 272630013253 dimer interface [polypeptide binding]; other site 272630013254 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 272630013255 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 272630013256 glutathionine S-transferase; Provisional; Region: PRK10542 272630013257 C-terminal domain interface [polypeptide binding]; other site 272630013258 GSH binding site (G-site) [chemical binding]; other site 272630013259 dimer interface [polypeptide binding]; other site 272630013260 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 272630013261 dimer interface [polypeptide binding]; other site 272630013262 substrate binding pocket (H-site) [chemical binding]; other site 272630013263 N-terminal domain interface [polypeptide binding]; other site 272630013264 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 272630013265 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 272630013266 active site 272630013267 dimer interface [polypeptide binding]; other site 272630013268 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272630013269 Ligand Binding Site [chemical binding]; other site 272630013270 Molecular Tunnel; other site 272630013271 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 272630013272 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 272630013273 putative active site [active] 272630013274 putative dimer interface [polypeptide binding]; other site 272630013275 RNA polymerase sigma factor; Provisional; Region: PRK12546 272630013276 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630013277 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272630013278 DNA binding residues [nucleotide binding] 272630013279 Response regulator receiver domain; Region: Response_reg; pfam00072 272630013280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630013281 active site 272630013282 phosphorylation site [posttranslational modification] 272630013283 intermolecular recognition site; other site 272630013284 dimerization interface [polypeptide binding]; other site 272630013285 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630013286 Histidine kinase; Region: HisKA_2; pfam07568 272630013287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630013288 ATP binding site [chemical binding]; other site 272630013289 Mg2+ binding site [ion binding]; other site 272630013290 G-X-G motif; other site 272630013291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630013292 Response regulator receiver domain; Region: Response_reg; pfam00072 272630013293 active site 272630013294 phosphorylation site [posttranslational modification] 272630013295 intermolecular recognition site; other site 272630013296 dimerization interface [polypeptide binding]; other site 272630013297 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 272630013298 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 272630013299 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 272630013300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630013301 putative active site [active] 272630013302 PAS fold; Region: PAS_3; pfam08447 272630013303 heme pocket [chemical binding]; other site 272630013304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630013305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630013306 dimer interface [polypeptide binding]; other site 272630013307 phosphorylation site [posttranslational modification] 272630013308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630013309 ATP binding site [chemical binding]; other site 272630013310 Mg2+ binding site [ion binding]; other site 272630013311 G-X-G motif; other site 272630013312 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272630013313 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272630013314 ligand binding site [chemical binding]; other site 272630013315 flexible hinge region; other site 272630013316 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272630013317 putative switch regulator; other site 272630013318 non-specific DNA interactions [nucleotide binding]; other site 272630013319 DNA binding site [nucleotide binding] 272630013320 sequence specific DNA binding site [nucleotide binding]; other site 272630013321 putative cAMP binding site [chemical binding]; other site 272630013322 GAF domain; Region: GAF; pfam01590 272630013323 GAF domain; Region: GAF_2; pfam13185 272630013324 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630013325 PAS fold; Region: PAS_3; pfam08447 272630013326 putative active site [active] 272630013327 heme pocket [chemical binding]; other site 272630013328 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 272630013329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630013330 active site 272630013331 phosphorylation site [posttranslational modification] 272630013332 intermolecular recognition site; other site 272630013333 dimerization interface [polypeptide binding]; other site 272630013334 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630013335 DNA binding residues [nucleotide binding] 272630013336 dimerization interface [polypeptide binding]; other site 272630013337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630013338 putative active site [active] 272630013339 heme pocket [chemical binding]; other site 272630013340 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 272630013341 potential frameshift: common BLAST hit: gi|220922626|ref|YP_002497928.1| Protein of unknown function DUF1810 272630013342 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 272630013343 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 272630013344 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272630013345 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272630013346 P-loop; other site 272630013347 Magnesium ion binding site [ion binding]; other site 272630013348 TIR domain; Region: TIR_2; pfam13676 272630013349 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 272630013350 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 272630013351 Protein of unknown function DUF262; Region: DUF262; pfam03235 272630013352 Uncharacterized conserved protein [Function unknown]; Region: COG1479 272630013353 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 272630013354 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272630013355 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272630013356 catalytic residues [active] 272630013357 catalytic nucleophile [active] 272630013358 Presynaptic Site I dimer interface [polypeptide binding]; other site 272630013359 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272630013360 Synaptic Flat tetramer interface [polypeptide binding]; other site 272630013361 Synaptic Site I dimer interface [polypeptide binding]; other site 272630013362 DNA binding site [nucleotide binding] 272630013363 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272630013364 DNA-binding interface [nucleotide binding]; DNA binding site 272630013365 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 272630013366 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272630013367 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272630013368 catalytic residues [active] 272630013369 catalytic nucleophile [active] 272630013370 Presynaptic Site I dimer interface [polypeptide binding]; other site 272630013371 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272630013372 Synaptic Flat tetramer interface [polypeptide binding]; other site 272630013373 Synaptic Site I dimer interface [polypeptide binding]; other site 272630013374 DNA binding site [nucleotide binding] 272630013375 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 272630013376 EF-hand domain pair; Region: EF_hand_5; pfam13499 272630013377 Ca2+ binding site [ion binding]; other site 272630013378 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630013379 non-specific DNA binding site [nucleotide binding]; other site 272630013380 salt bridge; other site 272630013381 sequence-specific DNA binding site [nucleotide binding]; other site 272630013382 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 272630013383 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 272630013384 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 272630013385 Multicopper oxidase; Region: Cu-oxidase; pfam00394 272630013386 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 272630013387 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272630013388 IHF dimer interface [polypeptide binding]; other site 272630013389 IHF - DNA interface [nucleotide binding]; other site 272630013390 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 272630013391 dimerization interface [polypeptide binding]; other site 272630013392 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 272630013393 MobA/MobL family; Region: MobA_MobL; pfam03389 272630013394 AAA domain; Region: AAA_30; pfam13604 272630013395 Family description; Region: UvrD_C_2; pfam13538 272630013396 Conjugal transfer protein TraD; Region: TraD; cl05753 272630013397 Conjugal transfer protein TraD; Region: TraD; cl05753 272630013398 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272630013399 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272630013400 P-loop; other site 272630013401 Magnesium ion binding site [ion binding]; other site 272630013402 Helix-turn-helix domain; Region: HTH_36; pfam13730 272630013403 Divergent AAA domain; Region: AAA_4; pfam04326 272630013404 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 272630013405 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630013406 non-specific DNA binding site [nucleotide binding]; other site 272630013407 salt bridge; other site 272630013408 sequence-specific DNA binding site [nucleotide binding]; other site 272630013409 multiple promoter invertase; Provisional; Region: mpi; PRK13413 272630013410 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272630013411 catalytic residues [active] 272630013412 catalytic nucleophile [active] 272630013413 Presynaptic Site I dimer interface [polypeptide binding]; other site 272630013414 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272630013415 Synaptic Flat tetramer interface [polypeptide binding]; other site 272630013416 Synaptic Site I dimer interface [polypeptide binding]; other site 272630013417 DNA binding site [nucleotide binding] 272630013418 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272630013419 DNA-binding interface [nucleotide binding]; DNA binding site 272630013420 Homeodomain-like domain; Region: HTH_23; cl17451 272630013421 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272630013422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630013423 Walker A motif; other site 272630013424 ATP binding site [chemical binding]; other site 272630013425 Walker B motif; other site 272630013426 arginine finger; other site 272630013427 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 272630013428 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272630013429 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 272630013430 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272630013431 active site 272630013432 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 272630013433 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 272630013434 KR domain; Region: KR; pfam08659 272630013435 putative NADP binding site [chemical binding]; other site 272630013436 active site 272630013437 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272630013438 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 272630013439 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272630013440 active site 272630013441 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 272630013442 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272630013443 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272630013444 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272630013445 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 272630013446 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272630013447 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272630013448 catalytic residue [active] 272630013449 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272630013450 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272630013451 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 272630013452 active site 272630013453 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630013454 ABC transporter signature motif; other site 272630013455 Walker B; other site 272630013456 D-loop; other site 272630013457 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272630013458 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272630013459 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272630013460 phosphate binding site [ion binding]; other site 272630013461 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272630013462 acyl-CoA synthetase; Validated; Region: PRK05850 272630013463 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 272630013464 acyl-activating enzyme (AAE) consensus motif; other site 272630013465 active site 272630013466 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 272630013467 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 272630013468 nucleophilic elbow; other site 272630013469 catalytic triad; other site 272630013470 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 272630013471 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 272630013472 iron-sulfur cluster [ion binding]; other site 272630013473 [2Fe-2S] cluster binding site [ion binding]; other site 272630013474 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 272630013475 Cytochrome P450; Region: p450; cl12078 272630013476 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 272630013477 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 272630013478 active site 272630013479 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 272630013480 TSCPD domain; Region: TSCPD; pfam12637 272630013481 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272630013482 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272630013483 catalytic residue [active] 272630013484 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 272630013485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630013486 active site 272630013487 phosphorylation site [posttranslational modification] 272630013488 intermolecular recognition site; other site 272630013489 dimerization interface [polypeptide binding]; other site 272630013490 Uncharacterized conserved protein [Function unknown]; Region: COG1432 272630013491 LabA_like proteins; Region: LabA; cd10911 272630013492 putative metal binding site [ion binding]; other site 272630013493 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 272630013494 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272630013495 cofactor binding site; other site 272630013496 DNA binding site [nucleotide binding] 272630013497 substrate interaction site [chemical binding]; other site 272630013498 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 272630013499 PRTRC system protein D; Region: PRTRC_D; TIGR03739 272630013500 Mg binding site [ion binding]; other site 272630013501 nucleotide binding site [chemical binding]; other site 272630013502 putative protofilament interface [polypeptide binding]; other site 272630013503 Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524 272630013504 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272630013505 Walker A motif; other site 272630013506 ATP binding site [chemical binding]; other site 272630013507 Walker B motif; other site 272630013508 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272630013509 active site 272630013510 Int/Topo IB signature motif; other site 272630013511 catalytic residues [active] 272630013512 DNA binding site [nucleotide binding] 272630013513 conserved hypothetical protein; Region: MG423; TIGR00649 272630013514 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272630013515 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 272630013516 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 272630013517 oxyanion hole [active] 272630013518 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 272630013519 active site 272630013520 oxyanion hole [active] 272630013521 catalytic triad [active] 272630013522 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 272630013523 active site 272630013524 catalytic triad [active] 272630013525 oxyanion hole [active] 272630013526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630013527 active site 272630013528 phosphorylation site [posttranslational modification] 272630013529 intermolecular recognition site; other site 272630013530 dimerization interface [polypeptide binding]; other site 272630013531 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 272630013532 HRDC domain; Region: HRDC; pfam00570 272630013533 YCII-related domain; Region: YCII; cl00999 272630013534 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 272630013535 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630013536 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 272630013537 Protein export membrane protein; Region: SecD_SecF; cl14618 272630013538 Domain of unknown function (DUF305); Region: DUF305; cl17794 272630013539 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 272630013540 dimerization interface [polypeptide binding]; other site 272630013541 YHS domain; Region: YHS; pfam04945 272630013542 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272630013543 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272630013544 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272630013545 motif II; other site 272630013546 Protein of unknown function, DUF; Region: DUF411; cl01142 272630013547 potential frameshift: common BLAST hit: gi|163851343|ref|YP_001639386.1| major facilitator transporter 272630013548 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272630013549 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272630013550 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 272630013551 putative homodimer interface [polypeptide binding]; other site 272630013552 putative homotetramer interface [polypeptide binding]; other site 272630013553 putative allosteric switch controlling residues; other site 272630013554 putative metal binding site [ion binding]; other site 272630013555 putative homodimer-homodimer interface [polypeptide binding]; other site 272630013556 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272630013557 metal-binding site [ion binding] 272630013558 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272630013559 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272630013560 YHS domain; Region: YHS; pfam04945 272630013561 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272630013562 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272630013563 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272630013564 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272630013565 catalytic residue [active] 272630013566 Protein of unknown function, DUF; Region: DUF411; cl01142 272630013567 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 272630013568 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 272630013569 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630013570 YtkA-like; Region: YtkA; pfam13115 272630013571 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 272630013572 RNA polymerase sigma factor; Provisional; Region: PRK12539 272630013573 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630013574 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 272630013575 DNA binding residues [nucleotide binding] 272630013576 Domain of unknown function (DUF305); Region: DUF305; cl17794 272630013577 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 272630013578 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 272630013579 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 272630013580 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 272630013581 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 272630013582 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 272630013583 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272630013584 Integrase core domain; Region: rve_3; pfam13683 272630013585 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 272630013586 MOFRL family; Region: MOFRL; pfam05161 272630013587 pyruvate kinase; Provisional; Region: PRK06247 272630013588 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 272630013589 domain interfaces; other site 272630013590 active site 272630013591 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 272630013592 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272630013593 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272630013594 dimerization interface [polypeptide binding]; other site 272630013595 putative DNA binding site [nucleotide binding]; other site 272630013596 putative Zn2+ binding site [ion binding]; other site 272630013597 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 272630013598 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272630013599 active site 272630013600 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 272630013601 ArsC family; Region: ArsC; pfam03960 272630013602 catalytic residues [active] 272630013603 potential frameshift: common BLAST hit: gi|218529068|ref|YP_002419884.1| arsenical-resistance protein 272630013604 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 272630013605 Sodium Bile acid symporter family; Region: SBF; cl17470 272630013606 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 272630013607 Sodium Bile acid symporter family; Region: SBF; cl17470 272630013608 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630013609 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272630013610 DNA binding residues [nucleotide binding] 272630013611 Fic/DOC family; Region: Fic; pfam02661 272630013612 Fic/DOC family; Region: Fic; cl00960 272630013613 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272630013614 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272630013615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630013616 active site 272630013617 phosphorylation site [posttranslational modification] 272630013618 intermolecular recognition site; other site 272630013619 dimerization interface [polypeptide binding]; other site 272630013620 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630013621 DNA binding site [nucleotide binding] 272630013622 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630013623 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630013624 dimerization interface [polypeptide binding]; other site 272630013625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630013626 ATP binding site [chemical binding]; other site 272630013627 Mg2+ binding site [ion binding]; other site 272630013628 G-X-G motif; other site 272630013629 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 272630013630 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630013631 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 272630013632 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 272630013633 Pleiotropic Drug Resistance (PDR) Family protein; Region: 3a01205; TIGR00956 272630013634 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 272630013635 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 272630013636 Abi-like protein; Region: Abi_2; pfam07751 272630013637 potential protein location (hypothetical protein associated with transposase of ISMdi3) that overlaps protein (hypothetical protein associated with transposase of ISMdi3) 272630013638 potential protein location (hypothetical protein associated with transposase of ISMdi3) that overlaps protein (hypothetical protein associated with transposase of ISMdi3) 272630013639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 272630013640 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 272630013641 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 272630013642 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272630013643 metal-binding site [ion binding] 272630013644 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272630013645 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272630013646 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 272630013647 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 272630013648 DNA binding residues [nucleotide binding] 272630013649 dimer interface [polypeptide binding]; other site 272630013650 putative metal binding site [ion binding]; other site 272630013651 YHS domain; Region: YHS; pfam04945 272630013652 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272630013653 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272630013654 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272630013655 Domain of unknown function (DUF305); Region: DUF305; cl17794 272630013656 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 272630013657 dimerization interface [polypeptide binding]; other site 272630013658 Domain of unknown function (DUF305); Region: DUF305; cl17794 272630013659 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 272630013660 Protein export membrane protein; Region: SecD_SecF; cl14618 272630013661 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 272630013662 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630013663 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 272630013664 metal-binding site [ion binding] 272630013665 LabA_like proteins; Region: LabA_like; cd06167 272630013666 Protein of unknown function, DUF; Region: DUF411; cl01142 272630013667 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 272630013668 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272630013669 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272630013670 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272630013671 ATP binding site [chemical binding]; other site 272630013672 putative Mg++ binding site [ion binding]; other site 272630013673 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630013674 nucleotide binding region [chemical binding]; other site 272630013675 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 272630013676 folate binding site [chemical binding]; other site 272630013677 NADP+ binding site [chemical binding]; other site 272630013678 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 272630013679 Probable transposase; Region: OrfB_IS605; pfam01385 272630013680 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 272630013681 Protein of unknown function (DUF3223); Region: DUF3223; pfam11523 272630013682 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 272630013683 generic binding surface II; other site 272630013684 generic binding surface I; other site 272630013685 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272630013686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630013687 non-specific DNA binding site [nucleotide binding]; other site 272630013688 salt bridge; other site 272630013689 sequence-specific DNA binding site [nucleotide binding]; other site 272630013690 HipA N-terminal domain; Region: couple_hipA; TIGR03071 272630013691 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 272630013692 HipA-like N-terminal domain; Region: HipA_N; pfam07805 272630013693 HipA-like C-terminal domain; Region: HipA_C; pfam07804 272630013694 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 272630013695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 272630013696 active site 272630013697 phosphorylation site [posttranslational modification] 272630013698 intermolecular recognition site; other site 272630013699 dimerization interface [polypeptide binding]; other site 272630013700 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 272630013701 RHS Repeat; Region: RHS_repeat; pfam05593 272630013702 RHS Repeat; Region: RHS_repeat; cl11982 272630013703 RHS protein; Region: RHS; pfam03527 272630013704 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 272630013705 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 272630013706 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 272630013707 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272630013708 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272630013709 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 272630013710 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 272630013711 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272630013712 Walker A motif; other site 272630013713 ATP binding site [chemical binding]; other site 272630013714 Walker B motif; other site 272630013715 type II secretion system protein D; Region: type_II_gspD; TIGR02517 272630013716 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 272630013717 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 272630013718 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 272630013719 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 272630013720 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 272630013721 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 272630013722 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 272630013723 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 272630013724 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 272630013725 trimer interface [polypeptide binding]; other site 272630013726 active site 272630013727 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 272630013728 trimer interface [polypeptide binding]; other site 272630013729 active site 272630013730 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 272630013731 Bacterial SH3 domain; Region: SH3_3; cl17532 272630013732 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 272630013733 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 272630013734 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 272630013735 Walker A/P-loop; other site 272630013736 ATP binding site [chemical binding]; other site 272630013737 Q-loop/lid; other site 272630013738 ABC transporter signature motif; other site 272630013739 Walker B; other site 272630013740 D-loop; other site 272630013741 H-loop/switch region; other site 272630013742 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 272630013743 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 272630013744 substrate binding pocket [chemical binding]; other site 272630013745 membrane-bound complex binding site; other site 272630013746 hinge residues; other site 272630013747 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272630013748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630013749 dimer interface [polypeptide binding]; other site 272630013750 conserved gate region; other site 272630013751 putative PBP binding loops; other site 272630013752 ABC-ATPase subunit interface; other site 272630013753 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272630013754 Thermostable Phosphite Dehydrogenase; Region: PTDH; cd12157 272630013755 homodimer interface [polypeptide binding]; other site 272630013756 ligand binding site [chemical binding]; other site 272630013757 NAD binding site [chemical binding]; other site 272630013758 catalytic site [active] 272630013759 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630013760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630013761 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 272630013762 putative dimerization interface [polypeptide binding]; other site 272630013763 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 272630013764 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272630013765 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272630013766 dimerization interface [polypeptide binding]; other site 272630013767 putative DNA binding site [nucleotide binding]; other site 272630013768 putative Zn2+ binding site [ion binding]; other site 272630013769 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 272630013770 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272630013771 active site 272630013772 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 272630013773 ArsC family; Region: ArsC; pfam03960 272630013774 catalytic residues [active] 272630013775 arsenical pump membrane protein; Provisional; Region: PRK15445 272630013776 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 272630013777 transmembrane helices; other site 272630013778 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 272630013779 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 272630013780 dimer interface [polypeptide binding]; other site 272630013781 putative functional site; other site 272630013782 putative MPT binding site; other site 272630013783 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 272630013784 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272630013785 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 272630013786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630013787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630013788 dimer interface [polypeptide binding]; other site 272630013789 phosphorylation site [posttranslational modification] 272630013790 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 272630013791 ATP binding site [chemical binding]; other site 272630013792 G-X-G motif; other site 272630013793 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 272630013794 active site 272630013795 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272630013796 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 272630013797 Uncharacterized conserved protein [Function unknown]; Region: COG2968 272630013798 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 272630013799 Mrr N-terminal domain; Region: Mrr_N; pfam14338 272630013800 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 272630013801 DNA methylase; Region: N6_N4_Mtase; pfam01555 272630013802 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 272630013803 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272630013804 active site 272630013805 metal binding site [ion binding]; metal-binding site 272630013806 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272630013807 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272630013808 active site 272630013809 metal binding site [ion binding]; metal-binding site 272630013810 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 272630013811 Part of AAA domain; Region: AAA_19; pfam13245 272630013812 Family description; Region: UvrD_C_2; pfam13538 272630013813 PilZ domain; Region: PilZ; cl01260 272630013814 Nuclease-related domain; Region: NERD; pfam08378 272630013815 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272630013816 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272630013817 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272630013818 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 272630013819 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 272630013820 active site 272630013821 substrate binding site [chemical binding]; other site 272630013822 Mg2+ binding site [ion binding]; other site 272630013823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630013824 Response regulator receiver domain; Region: Response_reg; pfam00072 272630013825 active site 272630013826 phosphorylation site [posttranslational modification] 272630013827 intermolecular recognition site; other site 272630013828 dimerization interface [polypeptide binding]; other site 272630013829 Cache domain; Region: Cache_1; pfam02743 272630013830 PAS domain; Region: PAS; smart00091 272630013831 PAS fold; Region: PAS_7; pfam12860 272630013832 PAS domain; Region: PAS; smart00091 272630013833 PAS fold; Region: PAS_7; pfam12860 272630013834 PAS fold; Region: PAS_7; pfam12860 272630013835 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630013836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630013837 dimer interface [polypeptide binding]; other site 272630013838 phosphorylation site [posttranslational modification] 272630013839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630013840 ATP binding site [chemical binding]; other site 272630013841 Mg2+ binding site [ion binding]; other site 272630013842 G-X-G motif; other site 272630013843 Response regulator receiver domain; Region: Response_reg; pfam00072 272630013844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630013845 active site 272630013846 phosphorylation site [posttranslational modification] 272630013847 intermolecular recognition site; other site 272630013848 dimerization interface [polypeptide binding]; other site 272630013849 PAS fold; Region: PAS_7; pfam12860 272630013850 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630013851 dimer interface [polypeptide binding]; other site 272630013852 phosphorylation site [posttranslational modification] 272630013853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630013854 ATP binding site [chemical binding]; other site 272630013855 Mg2+ binding site [ion binding]; other site 272630013856 G-X-G motif; other site 272630013857 Response regulator receiver domain; Region: Response_reg; pfam00072 272630013858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630013859 active site 272630013860 phosphorylation site [posttranslational modification] 272630013861 intermolecular recognition site; other site 272630013862 dimerization interface [polypeptide binding]; other site 272630013863 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 272630013864 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 272630013865 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 272630013866 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 272630013867 Catalytic site; other site 272630013868 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 272630013869 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 272630013870 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272630013871 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272630013872 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272630013873 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272630013874 Walker A/P-loop; other site 272630013875 ATP binding site [chemical binding]; other site 272630013876 Q-loop/lid; other site 272630013877 ABC transporter signature motif; other site 272630013878 Walker B; other site 272630013879 D-loop; other site 272630013880 H-loop/switch region; other site 272630013881 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 272630013882 putative carbohydrate binding site [chemical binding]; other site 272630013883 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272630013884 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272630013885 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272630013886 active site 272630013887 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 272630013888 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 272630013889 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 272630013890 Bundlin; Region: Bundlin; pfam05307 272630013891 PilS N terminal; Region: PilS; pfam08805 272630013892 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272630013893 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272630013894 Probable Catalytic site; other site 272630013895 metal-binding site 272630013896 Bacterial sugar transferase; Region: Bac_transf; pfam02397 272630013897 Acyltransferase family; Region: Acyl_transf_3; pfam01757 272630013898 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 272630013899 Helicase_C-like; Region: Helicase_C_4; pfam13871 272630013900 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 272630013901 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272630013902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272630013903 motif II; other site 272630013904 Shikimate kinase; Region: SKI; pfam01202 272630013905 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 272630013906 active site 272630013907 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 272630013908 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 272630013909 oligomer interface [polypeptide binding]; other site 272630013910 metal binding site [ion binding]; metal-binding site 272630013911 metal binding site [ion binding]; metal-binding site 272630013912 putative Cl binding site [ion binding]; other site 272630013913 basic sphincter; other site 272630013914 hydrophobic gate; other site 272630013915 periplasmic entrance; other site 272630013916 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272630013917 Domain of unknown function (DUF955); Region: DUF955; pfam06114 272630013918 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272630013919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630013920 non-specific DNA binding site [nucleotide binding]; other site 272630013921 salt bridge; other site 272630013922 sequence-specific DNA binding site [nucleotide binding]; other site 272630013923 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 272630013924 Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457 272630013925 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 272630013926 ATP binding site [chemical binding]; other site 272630013927 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 272630013928 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 272630013929 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 272630013930 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 272630013931 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272630013932 active site 272630013933 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272630013934 protein binding site [polypeptide binding]; other site 272630013935 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 272630013936 putative substrate binding region [chemical binding]; other site 272630013937 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 272630013938 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 272630013939 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 272630013940 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 272630013941 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 272630013942 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 272630013943 ADP-ribose binding site [chemical binding]; other site 272630013944 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 272630013945 nucleotide binding site [chemical binding]; other site 272630013946 polymerase nucleotide-binding site; other site 272630013947 primase nucleotide-binding site [nucleotide binding]; other site 272630013948 DNA-binding residues [nucleotide binding]; DNA binding site 272630013949 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 272630013950 DHH family; Region: DHH; pfam01368 272630013951 DHHA1 domain; Region: DHHA1; pfam02272 272630013952 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 272630013953 Part of AAA domain; Region: AAA_19; pfam13245 272630013954 Family description; Region: UvrD_C_2; pfam13538 272630013955 AAA-like domain; Region: AAA_10; pfam12846 272630013956 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 272630013957 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272630013958 active site 272630013959 catalytic site [active] 272630013960 substrate binding site [chemical binding]; other site 272630013961 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 272630013962 AAA domain; Region: AAA_30; pfam13604 272630013963 Family description; Region: UvrD_C_2; pfam13538 272630013964 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 272630013965 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 272630013966 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 272630013967 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 272630013968 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 272630013969 TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli...; Region: TOPRIM_TopoIA; cd01028 272630013970 active site 272630013971 interdomain interaction site; other site 272630013972 putative metal-binding site [ion binding]; other site 272630013973 nucleotide binding site [chemical binding]; other site 272630013974 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 272630013975 domain III; other site 272630013976 catalytic site [active] 272630013977 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 272630013978 domain IV; other site 272630013979 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 272630013980 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 272630013981 ParB-like nuclease domain; Region: ParBc; pfam02195 272630013982 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 272630013983 MerR family regulatory protein; Region: MerR; pfam00376 272630013984 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272630013985 P-loop; other site 272630013986 Magnesium ion binding site [ion binding]; other site 272630013987 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272630013988 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 272630013989 active site 272630013990 catalytic site [active] 272630013991 substrate binding site [chemical binding]; other site 272630013992 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630013993 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 272630013994 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 272630013995 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 272630013996 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272630013997 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272630013998 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 272630013999 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272630014000 Walker A motif; other site 272630014001 ATP binding site [chemical binding]; other site 272630014002 Walker B motif; other site 272630014003 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 272630014004 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 272630014005 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 272630014006 Peptidase M15; Region: Peptidase_M15_3; cl01194 272630014007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 272630014008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 272630014009 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 272630014010 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272630014011 active site 272630014012 DNA binding site [nucleotide binding] 272630014013 Int/Topo IB signature motif; other site 272630014014 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272630014015 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272630014016 catalytic residue [active] 272630014017 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 272630014018 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 272630014019 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272630014020 active site 272630014021 DNA gyrase subunit A; Validated; Region: PRK05560 272630014022 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272630014023 CAP-like domain; other site 272630014024 active site 272630014025 primary dimer interface [polypeptide binding]; other site 272630014026 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272630014027 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272630014028 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272630014029 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 272630014030 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272630014031 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 272630014032 cofactor binding site; other site 272630014033 DNA binding site [nucleotide binding] 272630014034 substrate interaction site [chemical binding]; other site 272630014035 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 272630014036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630014037 Mg2+ binding site [ion binding]; other site 272630014038 G-X-G motif; other site 272630014039 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272630014040 anchoring element; other site 272630014041 dimer interface [polypeptide binding]; other site 272630014042 ATP binding site [chemical binding]; other site 272630014043 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272630014044 active site 272630014045 putative metal-binding site [ion binding]; other site 272630014046 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272630014047 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272630014048 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 272630014049 HSP70 interaction site [polypeptide binding]; other site 272630014050 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272630014051 substrate binding site [polypeptide binding]; other site 272630014052 dimer interface [polypeptide binding]; other site 272630014053 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272630014054 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 272630014055 AAA domain; Region: AAA_30; pfam13604 272630014056 Family description; Region: UvrD_C_2; pfam13538 272630014057 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 272630014058 metal binding site [ion binding]; metal-binding site 272630014059 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 272630014060 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630014061 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 272630014062 Transglycosylase; Region: Transgly; pfam00912 272630014063 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272630014064 MarR family; Region: MarR_2; pfam12802 272630014065 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 272630014066 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 272630014067 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272630014068 active site 272630014069 HIGH motif; other site 272630014070 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272630014071 KMSK motif region; other site 272630014072 tRNA binding surface [nucleotide binding]; other site 272630014073 DALR anticodon binding domain; Region: DALR_1; smart00836 272630014074 anticodon binding site; other site 272630014075 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 272630014076 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272630014077 putative active site [active] 272630014078 putative metal binding site [ion binding]; other site 272630014079 thymidylate kinase; Region: DTMP_kinase; TIGR00041 272630014080 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272630014081 TMP-binding site; other site 272630014082 ATP-binding site [chemical binding]; other site 272630014083 hypothetical protein; Validated; Region: PRK09039 272630014084 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 272630014085 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 272630014086 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 272630014087 CRISPR/Cas system-associated RAMP superfamily protein Csf2; Region: Csf2_U; cl11864 272630014088 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cl08497 272630014089 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272630014090 active site 272630014091 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272630014092 Zn2+ binding site [ion binding]; other site 272630014093 Mg2+ binding site [ion binding]; other site 272630014094 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 272630014095 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 272630014096 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 272630014097 active site 272630014098 DNA binding site [nucleotide binding] 272630014099 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 272630014100 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272630014101 Catalytic site [active] 272630014102 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 272630014103 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 272630014104 Ca2+ binding site [ion binding]; other site 272630014105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272630014106 TPR motif; other site 272630014107 binding surface 272630014108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272630014109 TPR motif; other site 272630014110 binding surface 272630014111 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 272630014112 Putative Ig domain; Region: He_PIG; pfam05345 272630014113 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 272630014114 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 272630014115 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 272630014116 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 272630014117 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 272630014118 HipA N-terminal domain; Region: Couple_hipA; cl11853 272630014119 HipA-like N-terminal domain; Region: HipA_N; pfam07805 272630014120 HipA-like C-terminal domain; Region: HipA_C; pfam07804 272630014121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630014122 sequence-specific DNA binding site [nucleotide binding]; other site 272630014123 salt bridge; other site 272630014124 CRISPR-associated protein, Csx11 family; Region: cas_csx11; TIGR02682 272630014125 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 272630014126 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 272630014127 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 272630014128 GIY-YIG motif/motif A; other site 272630014129 putative active site [active] 272630014130 putative metal binding site [ion binding]; other site 272630014131 Competence protein CoiA-like family; Region: CoiA; cl11541 272630014132 Probable transposase; Region: OrfB_IS605; pfam01385 272630014133 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 272630014134 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 272630014135 C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD); Region: AP_MHD_Cterm; cl10970 272630014136 Tetrahydromethanopterin S-methyltransferase, subunit C; Region: MtrC; cl01677 272630014137 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 272630014138 chaperone protein dnaJ-related; Provisional; Region: PLN03165 272630014139 VRR-NUC domain; Region: VRR_NUC; cl17748 272630014140 MASE1; Region: MASE1; pfam05231 272630014141 PAS fold; Region: PAS_4; pfam08448 272630014142 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630014143 putative active site [active] 272630014144 heme pocket [chemical binding]; other site 272630014145 PAS domain S-box; Region: sensory_box; TIGR00229 272630014146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272630014147 putative active site [active] 272630014148 heme pocket [chemical binding]; other site 272630014149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630014150 dimer interface [polypeptide binding]; other site 272630014151 phosphorylation site [posttranslational modification] 272630014152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630014153 ATP binding site [chemical binding]; other site 272630014154 Mg2+ binding site [ion binding]; other site 272630014155 G-X-G motif; other site 272630014156 Response regulator receiver domain; Region: Response_reg; pfam00072 272630014157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630014158 active site 272630014159 phosphorylation site [posttranslational modification] 272630014160 intermolecular recognition site; other site 272630014161 dimerization interface [polypeptide binding]; other site 272630014162 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272630014163 putative binding surface; other site 272630014164 active site 272630014165 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 272630014166 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 272630014167 iron-sulfur cluster [ion binding]; other site 272630014168 [2Fe-2S] cluster binding site [ion binding]; other site 272630014169 Autoinducer synthetase; Region: Autoind_synth; cl17404 272630014170 Autoinducer binding domain; Region: Autoind_bind; pfam03472 272630014171 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 272630014172 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630014173 DNA binding residues [nucleotide binding] 272630014174 dimerization interface [polypeptide binding]; other site 272630014175 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272630014176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630014177 active site 272630014178 phosphorylation site [posttranslational modification] 272630014179 intermolecular recognition site; other site 272630014180 dimerization interface [polypeptide binding]; other site 272630014181 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630014182 DNA binding site [nucleotide binding] 272630014183 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 272630014184 active site 2 [active] 272630014185 active site 1 [active] 272630014186 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 272630014187 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 272630014188 SWIB/MDM2 domain; Region: SWIB; pfam02201 272630014189 AAA domain; Region: AAA_23; pfam13476 272630014190 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272630014191 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272630014192 Zn2+ binding site [ion binding]; other site 272630014193 Mg2+ binding site [ion binding]; other site 272630014194 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 272630014195 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 272630014196 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 272630014197 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 272630014198 active site 272630014199 catalytic site [active] 272630014200 substrate binding site [chemical binding]; other site 272630014201 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 272630014202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272630014203 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630014204 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 272630014205 Part of AAA domain; Region: AAA_19; pfam13245 272630014206 Family description; Region: UvrD_C_2; pfam13538 272630014207 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 272630014208 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 272630014209 active site 272630014210 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 272630014211 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 272630014212 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 272630014213 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272630014214 DNA topoisomerase III; Provisional; Region: PRK07726 272630014215 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 272630014216 active site 272630014217 putative interdomain interaction site [polypeptide binding]; other site 272630014218 putative metal-binding site [ion binding]; other site 272630014219 putative nucleotide binding site [chemical binding]; other site 272630014220 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272630014221 domain I; other site 272630014222 DNA binding groove [nucleotide binding] 272630014223 phosphate binding site [ion binding]; other site 272630014224 domain II; other site 272630014225 domain III; other site 272630014226 nucleotide binding site [chemical binding]; other site 272630014227 catalytic site [active] 272630014228 domain IV; other site 272630014229 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 272630014230 GRF zinc finger; Region: zf-GRF; pfam06839 272630014231 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 272630014232 Helicase_C-like; Region: Helicase_C_4; pfam13871 272630014233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630014234 phosphorylation site [posttranslational modification] 272630014235 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 272630014236 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272630014237 Walker A motif; other site 272630014238 ATP binding site [chemical binding]; other site 272630014239 Walker B motif; other site 272630014240 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 272630014241 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272630014242 Type II/IV secretion system protein; Region: T2SE; pfam00437 272630014243 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272630014244 Walker A motif; other site 272630014245 ATP binding site [chemical binding]; other site 272630014246 Walker B motif; other site 272630014247 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 272630014248 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 272630014249 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 272630014250 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 272630014251 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 272630014252 Homeodomain-like domain; Region: HTH_23; cl17451 272630014253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 272630014254 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272630014255 IHF dimer interface [polypeptide binding]; other site 272630014256 IHF - DNA interface [nucleotide binding]; other site 272630014257 RDD family; Region: RDD; pfam06271 272630014258 Initiator Replication protein; Region: Rep_3; pfam01051 272630014259 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 272630014260 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 272630014261 Catalytic site; other site 272630014262 GcrA cell cycle regulator; Region: GcrA; cl11564 272630014263 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272630014264 cofactor binding site; other site 272630014265 DNA binding site [nucleotide binding] 272630014266 substrate interaction site [chemical binding]; other site 272630014267 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 272630014268 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272630014269 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272630014270 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630014271 DNA binding residues [nucleotide binding] 272630014272 dimerization interface [polypeptide binding]; other site 272630014273 GcrA cell cycle regulator; Region: GcrA; cl11564 272630014274 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272630014275 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272630014276 cofactor binding site; other site 272630014277 DNA binding site [nucleotide binding] 272630014278 substrate interaction site [chemical binding]; other site 272630014279 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272630014280 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 272630014281 active site 272630014282 DNA binding site [nucleotide binding] 272630014283 Int/Topo IB signature motif; other site 272630014284 potential protein location (hypothetical protein; RMQ09560) that overlaps protein (Hypothetical protein) 272630014285 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272630014286 non-specific DNA binding site [nucleotide binding]; other site 272630014287 salt bridge; other site 272630014288 sequence-specific DNA binding site [nucleotide binding]; other site 272630014289 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 272630014290 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 272630014291 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 272630014292 additional DNA contacts [nucleotide binding]; other site 272630014293 mismatch recognition site; other site 272630014294 active site 272630014295 zinc binding site [ion binding]; other site 272630014296 DNA intercalation site [nucleotide binding]; other site 272630014297 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272630014298 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 272630014299 putative active site [active] 272630014300 putative metal binding site [ion binding]; other site 272630014301 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272630014302 active site 272630014303 Int/Topo IB signature motif; other site 272630014304 catalytic residues [active] 272630014305 DNA binding site [nucleotide binding] 272630014306 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 272630014307 active site 272630014308 catalytic site [active] 272630014309 substrate binding site [chemical binding]; other site 272630014310 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 272630014311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630014312 active site 272630014313 phosphorylation site [posttranslational modification] 272630014314 intermolecular recognition site; other site 272630014315 dimerization interface [polypeptide binding]; other site 272630014316 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272630014317 Zn2+ binding site [ion binding]; other site 272630014318 Mg2+ binding site [ion binding]; other site 272630014319 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272630014320 metal ion-dependent adhesion site (MIDAS); other site 272630014321 Predicted periplasmic protein [Function unknown]; Region: COG3904 272630014322 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272630014323 potential frameshift: common BLAST hit: gi|108804624|ref|YP_644561.1| superfamily I DNA/RNA helicase 272630014324 AAA domain; Region: AAA_11; pfam13086 272630014325 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 272630014326 AAA domain; Region: AAA_12; pfam13087 272630014327 Sporulation related domain; Region: SPOR; cl10051 272630014328 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272630014329 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272630014330 active site 272630014331 metal binding site [ion binding]; metal-binding site 272630014332 Uncharacterized conserved protein [Function unknown]; Region: COG1479 272630014333 Protein of unknown function DUF262; Region: DUF262; pfam03235 272630014334 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 272630014335 active site 272630014336 DNA polymerase IV; Validated; Region: PRK02406 272630014337 DNA binding site [nucleotide binding] 272630014338 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 272630014339 GIY-YIG motif/motif A; other site 272630014340 active site 272630014341 catalytic site [active] 272630014342 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272630014343 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272630014344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272630014345 Coenzyme A binding pocket [chemical binding]; other site 272630014346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272630014347 Coenzyme A binding pocket [chemical binding]; other site 272630014348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630014349 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272630014350 Walker A motif; other site 272630014351 ATP binding site [chemical binding]; other site 272630014352 Walker B motif; other site 272630014353 arginine finger; other site 272630014354 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 272630014355 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272630014356 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272630014357 active site 272630014358 catalytic tetrad [active] 272630014359 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272630014360 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272630014361 active site 272630014362 catalytic tetrad [active] 272630014363 Predicted flavoprotein [General function prediction only]; Region: COG0431 272630014364 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272630014365 CHAD domain; Region: CHAD; pfam05235 272630014366 Cytochrome c; Region: Cytochrom_C; pfam00034 272630014367 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272630014368 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272630014369 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272630014370 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 272630014371 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272630014372 catalytic loop [active] 272630014373 iron binding site [ion binding]; other site 272630014374 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 272630014375 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272630014376 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 272630014377 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 272630014378 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272630014379 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272630014380 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 272630014381 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 272630014382 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939 272630014383 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 272630014384 Clp amino terminal domain; Region: Clp_N; pfam02861 272630014385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630014386 Walker A motif; other site 272630014387 ATP binding site [chemical binding]; other site 272630014388 Walker B motif; other site 272630014389 arginine finger; other site 272630014390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630014391 Walker A motif; other site 272630014392 ATP binding site [chemical binding]; other site 272630014393 Walker B motif; other site 272630014394 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272630014395 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 272630014396 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 272630014397 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 272630014398 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272630014399 HSP70 interaction site [polypeptide binding]; other site 272630014400 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272630014401 substrate binding site [polypeptide binding]; other site 272630014402 dimer interface [polypeptide binding]; other site 272630014403 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272630014404 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272630014405 nucleotide binding site [chemical binding]; other site 272630014406 potential protein location (hypothetical protein; RMQ06983) that overlaps protein (hypothetical protein) 272630014407 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein; RMQ06983) 272630014408 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 272630014409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630014410 Walker A motif; other site 272630014411 ATP binding site [chemical binding]; other site 272630014412 Walker B motif; other site 272630014413 arginine finger; other site 272630014414 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272630014415 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 272630014416 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272630014417 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 272630014418 putative dimer interface [polypeptide binding]; other site 272630014419 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272630014420 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 272630014421 putative dimer interface [polypeptide binding]; other site 272630014422 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272630014423 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 272630014424 putative dimer interface [polypeptide binding]; other site 272630014425 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272630014426 MarR family; Region: MarR_2; pfam12802 272630014427 FtsH Extracellular; Region: FtsH_ext; pfam06480 272630014428 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 272630014429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630014430 Walker A motif; other site 272630014431 ATP binding site [chemical binding]; other site 272630014432 Walker B motif; other site 272630014433 arginine finger; other site 272630014434 Peptidase family M41; Region: Peptidase_M41; pfam01434 272630014435 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 272630014436 Clp amino terminal domain; Region: Clp_N; pfam02861 272630014437 Clp amino terminal domain; Region: Clp_N; pfam02861 272630014438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630014439 Walker A motif; other site 272630014440 ATP binding site [chemical binding]; other site 272630014441 Walker B motif; other site 272630014442 arginine finger; other site 272630014443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630014444 Walker A motif; other site 272630014445 ATP binding site [chemical binding]; other site 272630014446 Walker B motif; other site 272630014447 arginine finger; other site 272630014448 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272630014449 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 272630014450 30S subunit binding site; other site 272630014451 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 272630014452 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 272630014453 YfdX protein; Region: YfdX; pfam10938 272630014454 YfdX protein; Region: YfdX; pfam10938 272630014455 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 272630014456 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272630014457 ParA-like protein; Provisional; Region: PHA02518 272630014458 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272630014459 P-loop; other site 272630014460 Magnesium ion binding site [ion binding]; other site 272630014461 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 272630014462 Predicted transcriptional regulator [Transcription]; Region: COG3905 272630014463 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272630014464 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272630014465 active site 272630014466 catalytic tetrad [active] 272630014467 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 272630014468 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272630014469 NAD binding site [chemical binding]; other site 272630014470 catalytic Zn binding site [ion binding]; other site 272630014471 structural Zn binding site [ion binding]; other site 272630014472 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 272630014473 putative hydrophobic ligand binding site [chemical binding]; other site 272630014474 thioredoxin 2; Provisional; Region: PRK10996 272630014475 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272630014476 catalytic residues [active] 272630014477 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 272630014478 TniQ; Region: TniQ; pfam06527 272630014479 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 272630014480 RNB domain; Region: RNB; pfam00773 272630014481 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272630014482 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272630014483 dsRNA binding site [nucleotide binding]; other site 272630014484 transcriptional regulator TraR; Provisional; Region: PRK13870 272630014485 Autoinducer binding domain; Region: Autoind_bind; pfam03472 272630014486 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630014487 DNA binding residues [nucleotide binding] 272630014488 dimerization interface [polypeptide binding]; other site 272630014489 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 272630014490 Autoinducer binding domain; Region: Autoind_bind; pfam03472 272630014491 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630014492 DNA binding residues [nucleotide binding] 272630014493 dimerization interface [polypeptide binding]; other site 272630014494 5'-3' exonuclease; Region: 53EXOc; smart00475 272630014495 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272630014496 active site 272630014497 metal binding site 1 [ion binding]; metal-binding site 272630014498 putative 5' ssDNA interaction site; other site 272630014499 metal binding site 3; metal-binding site 272630014500 metal binding site 2 [ion binding]; metal-binding site 272630014501 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272630014502 putative DNA binding site [nucleotide binding]; other site 272630014503 putative metal binding site [ion binding]; other site 272630014504 DNA primase, catalytic core; Region: dnaG; TIGR01391 272630014505 CHC2 zinc finger; Region: zf-CHC2; pfam01807 272630014506 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272630014507 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272630014508 active site 272630014509 metal binding site [ion binding]; metal-binding site 272630014510 interdomain interaction site; other site 272630014511 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 272630014512 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 272630014513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272630014514 Coenzyme A binding pocket [chemical binding]; other site 272630014515 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 272630014516 DNA polymerase I; Provisional; Region: PRK05755 272630014517 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272630014518 active site 272630014519 metal binding site 1 [ion binding]; metal-binding site 272630014520 putative 5' ssDNA interaction site; other site 272630014521 metal binding site 3; metal-binding site 272630014522 metal binding site 2 [ion binding]; metal-binding site 272630014523 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272630014524 putative DNA binding site [nucleotide binding]; other site 272630014525 putative metal binding site [ion binding]; other site 272630014526 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 272630014527 active site 272630014528 substrate binding site [chemical binding]; other site 272630014529 catalytic site [active] 272630014530 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272630014531 active site 272630014532 DNA binding site [nucleotide binding] 272630014533 catalytic site [active] 272630014534 potential frameshift: common BLAST hit: gi|190410730|ref|YP_001966068.1| DNA-cytosine methyltransferase 272630014535 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272630014536 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 272630014537 cofactor binding site; other site 272630014538 DNA binding site [nucleotide binding] 272630014539 substrate interaction site [chemical binding]; other site 272630014540 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272630014541 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 272630014542 Nuclease-related domain; Region: NERD; pfam08378 272630014543 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 272630014544 nudix motif; other site 272630014545 Flagellin N-methylase; Region: FliB; cl00497 272630014546 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 272630014547 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272630014548 AMP-binding site [chemical binding]; other site 272630014549 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272630014550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630014551 ATP binding site [chemical binding]; other site 272630014552 Mg2+ binding site [ion binding]; other site 272630014553 G-X-G motif; other site 272630014554 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630014555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630014556 active site 272630014557 phosphorylation site [posttranslational modification] 272630014558 intermolecular recognition site; other site 272630014559 dimerization interface [polypeptide binding]; other site 272630014560 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 272630014561 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272630014562 nucleotide binding pocket [chemical binding]; other site 272630014563 K-X-D-G motif; other site 272630014564 catalytic site [active] 272630014565 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272630014566 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272630014567 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272630014568 Dimer interface [polypeptide binding]; other site 272630014569 BRCT sequence motif; other site 272630014570 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272630014571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630014572 Walker A motif; other site 272630014573 ATP binding site [chemical binding]; other site 272630014574 Walker B motif; other site 272630014575 arginine finger; other site 272630014576 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272630014577 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272630014578 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 272630014579 catalytic site [active] 272630014580 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 272630014581 active site 272630014582 catalytic residue [active] 272630014583 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272630014584 Predicted transporter component [General function prediction only]; Region: COG2391 272630014585 Sulphur transport; Region: Sulf_transp; pfam04143 272630014586 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 272630014587 DsrE/DsrF-like family; Region: DrsE; cl00672 272630014588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272630014589 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630014590 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 272630014591 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 272630014592 catalytic residues [active] 272630014593 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 272630014594 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 272630014595 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 272630014596 DsbD alpha interface [polypeptide binding]; other site 272630014597 catalytic residues [active] 272630014598 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 272630014599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630014600 active site 272630014601 phosphorylation site [posttranslational modification] 272630014602 intermolecular recognition site; other site 272630014603 dimerization interface [polypeptide binding]; other site 272630014604 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630014605 DNA binding site [nucleotide binding] 272630014606 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 272630014607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630014608 dimer interface [polypeptide binding]; other site 272630014609 phosphorylation site [posttranslational modification] 272630014610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630014611 ATP binding site [chemical binding]; other site 272630014612 Mg2+ binding site [ion binding]; other site 272630014613 G-X-G motif; other site 272630014614 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272630014615 putative Zn2+ binding site [ion binding]; other site 272630014616 putative DNA binding site [nucleotide binding]; other site 272630014617 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 272630014618 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 272630014619 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 272630014620 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 272630014621 DPS ferroxidase diiron center [ion binding]; other site 272630014622 dimerization interface [polypeptide binding]; other site 272630014623 ion pore; other site 272630014624 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 272630014625 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 272630014626 heme binding site [chemical binding]; other site 272630014627 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 272630014628 heme binding site [chemical binding]; other site 272630014629 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 272630014630 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272630014631 dimerization interface [polypeptide binding]; other site 272630014632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630014633 ATP binding site [chemical binding]; other site 272630014634 Mg2+ binding site [ion binding]; other site 272630014635 G-X-G motif; other site 272630014636 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272630014637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630014638 active site 272630014639 phosphorylation site [posttranslational modification] 272630014640 intermolecular recognition site; other site 272630014641 dimerization interface [polypeptide binding]; other site 272630014642 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272630014643 DNA binding site [nucleotide binding] 272630014644 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272630014645 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 272630014646 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630014647 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 272630014648 RNA polymerase sigma factor; Provisional; Region: PRK12547 272630014649 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630014650 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 272630014651 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272630014652 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 272630014653 catalytic residues [active] 272630014654 catalytic nucleophile [active] 272630014655 Recombinase; Region: Recombinase; pfam07508 272630014656 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272630014657 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272630014658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630014659 active site 272630014660 phosphorylation site [posttranslational modification] 272630014661 intermolecular recognition site; other site 272630014662 dimerization interface [polypeptide binding]; other site 272630014663 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 272630014664 HSP70 interaction site [polypeptide binding]; other site 272630014665 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 272630014666 nudix motif; other site 272630014667 Bacteriophage lambda tail assembly protein I; Region: Lambda_tail_I; cl01945 272630014668 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 272630014669 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272630014670 active site 272630014671 HIGH motif; other site 272630014672 dimer interface [polypeptide binding]; other site 272630014673 KMSKS motif; other site 272630014674 enoyl-CoA hydratase; Validated; Region: PRK08788 272630014675 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272630014676 substrate binding site [chemical binding]; other site 272630014677 oxyanion hole (OAH) forming residues; other site 272630014678 trimer interface [polypeptide binding]; other site 272630014679 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630014680 metal binding site [ion binding]; metal-binding site 272630014681 active site 272630014682 I-site; other site 272630014683 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272630014684 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272630014685 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272630014686 ATP binding site [chemical binding]; other site 272630014687 putative Mg++ binding site [ion binding]; other site 272630014688 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630014689 nucleotide binding region [chemical binding]; other site 272630014690 ATP-binding site [chemical binding]; other site 272630014691 Thioredoxin; Region: Thioredoxin_4; pfam13462 272630014692 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 272630014693 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272630014694 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272630014695 metal binding site [ion binding]; metal-binding site 272630014696 active site 272630014697 I-site; other site 272630014698 DGQHR domain; Region: DGQHR; TIGR03187 272630014699 preprotein translocase, SecA subunit; Region: secA; TIGR00963 272630014700 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272630014701 ATP binding site [chemical binding]; other site 272630014702 putative Mg++ binding site [ion binding]; other site 272630014703 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 272630014704 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 272630014705 nucleotide binding region [chemical binding]; other site 272630014706 ATP-binding site [chemical binding]; other site 272630014707 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272630014708 Active Sites [active] 272630014709 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 272630014710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630014711 Walker A/P-loop; other site 272630014712 ATP binding site [chemical binding]; other site 272630014713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630014714 ABC transporter signature motif; other site 272630014715 Walker B; other site 272630014716 D-loop; other site 272630014717 H-loop/switch region; other site 272630014718 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 272630014719 AAA-like domain; Region: AAA_10; pfam12846 272630014720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630014721 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272630014722 Walker A motif; other site 272630014723 ATP binding site [chemical binding]; other site 272630014724 Walker B motif; other site 272630014725 arginine finger; other site 272630014726 Abortive infection C-terminus; Region: Abi_C; pfam14355 272630014727 Uncharacterized conserved protein [Function unknown]; Region: COG1479 272630014728 Protein of unknown function DUF262; Region: DUF262; pfam03235 272630014729 Protein of unknown function DUF262; Region: DUF262; pfam03235 272630014730 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 272630014731 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272630014732 Sel1-like repeats; Region: SEL1; smart00671 272630014733 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272630014734 Sel1-like repeats; Region: SEL1; smart00671 272630014735 Sel1-like repeats; Region: SEL1; smart00671 272630014736 Sel1-like repeats; Region: SEL1; smart00671 272630014737 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 272630014738 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272630014739 active site 272630014740 catalytic site [active] 272630014741 substrate binding site [chemical binding]; other site 272630014742 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 272630014743 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272630014744 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 272630014745 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 272630014746 Integrase core domain; Region: rve_3; pfam13683 272630014747 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 272630014748 probable biosynthetic protein, Pnap_2097 family; Region: biosn_Pnap_2097; TIGR04099 272630014749 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 272630014750 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 272630014751 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272630014752 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 272630014753 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 272630014754 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272630014755 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 272630014756 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 272630014757 dimerization interface [polypeptide binding]; other site 272630014758 putative ATP binding site [chemical binding]; other site 272630014759 putative N-acetyltransferase, MSMEG_0567 N-terminal domain family; Region: MSMEG_0567_GNAT; TIGR04045 272630014760 Coenzyme A binding pocket [chemical binding]; other site 272630014761 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 272630014762 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272630014763 FeS/SAM binding site; other site 272630014764 Predicted amidohydrolase [General function prediction only]; Region: COG0388 272630014765 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 272630014766 putative active site [active] 272630014767 catalytic triad [active] 272630014768 putative dimer interface [polypeptide binding]; other site 272630014769 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 272630014770 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272630014771 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272630014772 DNA-binding site [nucleotide binding]; DNA binding site 272630014773 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272630014774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630014775 homodimer interface [polypeptide binding]; other site 272630014776 catalytic residue [active] 272630014777 Predicted amidohydrolase [General function prediction only]; Region: COG0388 272630014778 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 272630014779 putative active site [active] 272630014780 catalytic triad [active] 272630014781 putative dimer interface [polypeptide binding]; other site 272630014782 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 272630014783 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272630014784 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 272630014785 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 272630014786 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 272630014787 substrate-cofactor binding pocket; other site 272630014788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630014789 catalytic residue [active] 272630014790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 272630014791 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272630014792 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272630014793 DNA-binding site [nucleotide binding]; DNA binding site 272630014794 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272630014795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272630014796 homodimer interface [polypeptide binding]; other site 272630014797 catalytic residue [active] 272630014798 potassium-tellurite ethidium and proflavin transporter; Provisional; Region: PRK10764 272630014799 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 272630014800 gating phenylalanine in ion channel; other site 272630014801 Cytochrome c; Region: Cytochrom_C; cl11414 272630014802 Predicted membrane protein [Function unknown]; Region: COG3918 272630014803 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 272630014804 potential frameshift: common BLAST hit: gi|218529247|ref|YP_002420063.1| Ion transport 2 domain protein 272630014805 Ion channel; Region: Ion_trans_2; pfam07885 272630014806 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 272630014807 Protein of unknown function (DUF421); Region: DUF421; pfam04239 272630014808 Predicted membrane protein [Function unknown]; Region: COG4325 272630014809 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 272630014810 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272630014811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630014812 active site 272630014813 phosphorylation site [posttranslational modification] 272630014814 intermolecular recognition site; other site 272630014815 dimerization interface [polypeptide binding]; other site 272630014816 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272630014817 DNA binding residues [nucleotide binding] 272630014818 dimerization interface [polypeptide binding]; other site 272630014819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272630014820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630014821 ATP binding site [chemical binding]; other site 272630014822 Mg2+ binding site [ion binding]; other site 272630014823 G-X-G motif; other site 272630014824 BA14K-like protein; Region: BA14K; pfam07886 272630014825 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 272630014826 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 272630014827 Helix-turn-helix domain; Region: HTH_17; pfam12728 272630014828 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 272630014829 aromatic chitin/cellulose binding site residues [chemical binding]; other site 272630014830 RWP-RK domain; Region: RWP-RK; pfam02042 272630014831 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 272630014832 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 272630014833 putative active site [active] 272630014834 putative metal binding site [ion binding]; other site 272630014835 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 272630014836 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272630014837 active site 272630014838 DNA binding site [nucleotide binding] 272630014839 Int/Topo IB signature motif; other site 272630014840 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 272630014841 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272630014842 ATP binding site [chemical binding]; other site 272630014843 putative Mg++ binding site [ion binding]; other site 272630014844 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630014845 ATP-binding site [chemical binding]; other site 272630014846 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 272630014847 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272630014848 ATP binding site [chemical binding]; other site 272630014849 putative Mg++ binding site [ion binding]; other site 272630014850 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272630014851 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272630014852 nucleotide binding region [chemical binding]; other site 272630014853 ATP-binding site [chemical binding]; other site 272630014854 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 272630014855 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 272630014856 HNH endonuclease; Region: HNH_2; pfam13391 272630014857 EamA-like transporter family; Region: EamA; pfam00892 272630014858 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 272630014859 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 272630014860 putative NAD(P) binding site [chemical binding]; other site 272630014861 dimer interface [polypeptide binding]; other site 272630014862 Cupin domain; Region: Cupin_2; pfam07883 272630014863 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630014864 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272630014865 dimerization interface [polypeptide binding]; other site 272630014866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272630014867 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272630014868 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 272630014869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272630014870 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 272630014871 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 272630014872 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630014873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630014874 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272630014875 dimerization interface [polypeptide binding]; other site 272630014876 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 272630014877 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 272630014878 putative NAD(P) binding site [chemical binding]; other site 272630014879 Major royal jelly protein; Region: MRJP; pfam03022 272630014880 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 272630014881 Major royal jelly protein; Region: MRJP; pfam03022 272630014882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630014883 active site 272630014884 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 272630014885 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272630014886 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272630014887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272630014888 NAD(P) binding site [chemical binding]; other site 272630014889 active site 272630014890 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272630014891 active site 272630014892 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 272630014893 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 272630014894 Walker A/P-loop; other site 272630014895 ATP binding site [chemical binding]; other site 272630014896 Q-loop/lid; other site 272630014897 ABC transporter signature motif; other site 272630014898 Walker B; other site 272630014899 D-loop; other site 272630014900 H-loop/switch region; other site 272630014901 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 272630014902 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 272630014903 substrate binding pocket [chemical binding]; other site 272630014904 membrane-bound complex binding site; other site 272630014905 hinge residues; other site 272630014906 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272630014907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272630014908 dimer interface [polypeptide binding]; other site 272630014909 conserved gate region; other site 272630014910 putative PBP binding loops; other site 272630014911 ABC-ATPase subunit interface; other site 272630014912 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272630014913 Thermostable Phosphite Dehydrogenase; Region: PTDH; cd12157 272630014914 homodimer interface [polypeptide binding]; other site 272630014915 ligand binding site [chemical binding]; other site 272630014916 NAD binding site [chemical binding]; other site 272630014917 catalytic site [active] 272630014918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272630014919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272630014920 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272630014921 dimerization interface [polypeptide binding]; other site 272630014922 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272630014923 classical (c) SDRs; Region: SDR_c; cd05233 272630014924 NAD(P) binding site [chemical binding]; other site 272630014925 active site 272630014926 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272630014927 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272630014928 Coenzyme A binding pocket [chemical binding]; other site 272630014929 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 272630014930 potential frameshift: common BLAST hit: gi|220927223|ref|YP_002502525.1| protein of unknown function DUF1254 272630014931 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 272630014932 Uncharacterized conserved protein [Function unknown]; Region: COG5361 272630014933 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 272630014934 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 272630014935 AAA domain; Region: AAA_22; pfam13401 272630014936 TniQ; Region: TniQ; pfam06527 272630014937 elongation factor Ts; Region: tsf; CHL00098 272630014938 Protein of unknown function, DUF488; Region: DUF488; pfam04343 272630014939 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272630014940 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 272630014941 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 272630014942 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 272630014943 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 272630014944 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 272630014945 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272630014946 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272630014947 Active Sites [active] 272630014948 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 272630014949 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272630014950 RNA/DNA hybrid binding site [nucleotide binding]; other site 272630014951 active site 272630014952 AAA domain; Region: AAA_33; pfam13671 272630014953 RNA ligase; Region: RNA_ligase; pfam09414 272630014954 PAS fold; Region: PAS_4; pfam08448 272630014955 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272630014956 HWE histidine kinase; Region: HWE_HK; smart00911 272630014957 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 272630014958 Predicted membrane protein [Function unknown]; Region: COG3766 272630014959 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 272630014960 Peptidase S8 family domain in Protein convertases; Region: Peptidases_S8_Protein_convertases_Kexins_Furin-lik; cd04059 272630014961 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 272630014962 active site 272630014963 catalytic triad [active] 272630014964 calcium binding site 1 [ion binding]; other site 272630014965 calcium binding site 2 [ion binding]; other site 272630014966 calcium binding site 3 [ion binding]; other site 272630014967 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 272630014968 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 272630014969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272630014970 Walker A/P-loop; other site 272630014971 ATP binding site [chemical binding]; other site 272630014972 Q-loop/lid; other site 272630014973 ABC transporter signature motif; other site 272630014974 Walker B; other site 272630014975 D-loop; other site 272630014976 H-loop/switch region; other site 272630014977 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272630014978 HlyD family secretion protein; Region: HlyD_3; pfam13437 272630014979 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272630014980 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272630014981 dimer interface [polypeptide binding]; other site 272630014982 phosphorylation site [posttranslational modification] 272630014983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272630014984 ATP binding site [chemical binding]; other site 272630014985 Mg2+ binding site [ion binding]; other site 272630014986 G-X-G motif; other site 272630014987 Response regulator receiver domain; Region: Response_reg; pfam00072 272630014988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272630014989 active site 272630014990 phosphorylation site [posttranslational modification] 272630014991 intermolecular recognition site; other site 272630014992 dimerization interface [polypeptide binding]; other site 272630014993 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272630014994 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 272630014995 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272630014996 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272630014997 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272630014998 DNA binding residues [nucleotide binding] 272630014999 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272630015000 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272630015001 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272630015002 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272630015003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 272630015004 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 272630015005 Probable transposase; Region: OrfB_IS605; pfam01385 272630015006 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 272630015007 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 272630015008 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 272630015009 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272630015010 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 272630015011 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272630015012 AAA domain; Region: AAA_23; pfam13476 272630015013 Walker A/P-loop; other site 272630015014 ATP binding site [chemical binding]; other site 272630015015 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272630015016 ABC transporter signature motif; other site 272630015017 Walker B; other site 272630015018 D-loop; other site 272630015019 H-loop/switch region; other site 272630015020 flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688 272630015021 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272630015022 HEAT repeats; Region: HEAT_2; pfam13646 272630015023 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 272630015024 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 272630015025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272630015026 Walker A motif; other site 272630015027 ATP binding site [chemical binding]; other site 272630015028 Walker B motif; other site