-- dump date   	20140619_144352
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
661410000001	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
661410000002	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
661410000003	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
661410000004	DNA binding residues [nucleotide binding]
661410000005	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
661410000006	P-loop; other site
661410000007	Magnesium ion binding site [ion binding]; other site
661410000008	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
661410000009	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
661410000010	ParB-like nuclease domain; Region: ParBc; pfam02195
661410000011	replication initiation protein RepC; Provisional; Region: PRK13824
661410000012	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
661410000013	putative DNA binding site [nucleotide binding]; other site
661410000014	putative Zn2+ binding site [ion binding]; other site
661410000015	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
661410000016	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410000017	H-loop/switch region; other site
661410000018	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
661410000019	Integrase core domain; Region: rve; pfam00665
661410000020	transposase; Provisional; Region: PRK06526
661410000021	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410000022	Walker A motif; other site
661410000023	ATP binding site [chemical binding]; other site
661410000024	Walker B motif; other site
661410000025	arginine finger; other site
661410000026	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
661410000027	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
661410000028	Transposase; Region: DDE_Tnp_ISL3; pfam01610
661410000029	Helix-turn-helix domain; Region: HTH_17; pfam12728
661410000030	Transposase; Region: DDE_Tnp_ISL3; pfam01610
661410000031	Transposase, Mutator family; Region: Transposase_mut; pfam00872
661410000032	MULE transposase domain; Region: MULE; pfam10551
661410000033	Protein of unknown function, DUF485; Region: DUF485; pfam04341
661410000034	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
661410000035	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
661410000036	Na binding site [ion binding]; other site
661410000037	Integrase core domain; Region: rve; pfam00665
661410000038	Integrase core domain; Region: rve_3; pfam13683
661410000039	FIST N domain; Region: FIST; pfam08495
661410000040	Uncharacterized conserved protein [Function unknown]; Region: COG3287
661410000041	FIST C domain; Region: FIST_C; pfam10442
661410000042	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
661410000043	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
661410000044	ligand binding site [chemical binding]; other site
661410000045	NAD binding site [chemical binding]; other site
661410000046	tetramer interface [polypeptide binding]; other site
661410000047	catalytic site [active]
661410000048	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
661410000049	L-serine binding site [chemical binding]; other site
661410000050	ACT domain interface; other site
661410000051	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
661410000052	FAD binding domain; Region: FAD_binding_4; pfam01565
661410000053	CHAT domain; Region: CHAT; pfam12770
661410000054	Helix-turn-helix domain; Region: HTH_38; pfam13936
661410000055	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
661410000056	Integrase core domain; Region: rve; pfam00665
661410000057	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
661410000058	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
661410000059	NAD binding site [chemical binding]; other site
661410000060	substrate binding site [chemical binding]; other site
661410000061	homodimer interface [polypeptide binding]; other site
661410000062	active site
661410000063	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
661410000064	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
661410000065	NADP binding site [chemical binding]; other site
661410000066	active site
661410000067	putative substrate binding site [chemical binding]; other site
661410000068	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
661410000069	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
661410000070	substrate binding site; other site
661410000071	tetramer interface; other site
661410000072	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
661410000073	DDE superfamily endonuclease; Region: DDE_5; pfam13546
661410000074	transposase/IS protein; Provisional; Region: PRK09183
661410000075	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
661410000076	Walker A motif; other site
661410000077	ATP binding site [chemical binding]; other site
661410000078	Walker B motif; other site
661410000079	arginine finger; other site
661410000080	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
661410000081	Integrase core domain; Region: rve; pfam00665
661410000082	TIR domain; Region: TIR_2; pfam13676
661410000083	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
661410000084	DNA binding site [nucleotide binding]
661410000085	dimer interface [polypeptide binding]; other site
661410000086	active site
661410000087	Int/Topo IB signature motif; other site
661410000088	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
661410000089	putative active site [active]
661410000090	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
661410000091	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
661410000092	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
661410000093	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
661410000094	succinic semialdehyde dehydrogenase; Region: PLN02278
661410000095	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
661410000096	tetramerization interface [polypeptide binding]; other site
661410000097	NAD(P) binding site [chemical binding]; other site
661410000098	catalytic residues [active]
661410000099	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
661410000100	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
661410000101	putative active site [active]
661410000102	metal binding site [ion binding]; metal-binding site
661410000103	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
661410000104	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
661410000105	Walker A/P-loop; other site
661410000106	ATP binding site [chemical binding]; other site
661410000107	Q-loop/lid; other site
661410000108	ABC transporter signature motif; other site
661410000109	Walker B; other site
661410000110	D-loop; other site
661410000111	H-loop/switch region; other site
661410000112	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
661410000113	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
661410000114	Walker A/P-loop; other site
661410000115	ATP binding site [chemical binding]; other site
661410000116	Q-loop/lid; other site
661410000117	ABC transporter signature motif; other site
661410000118	Walker B; other site
661410000119	D-loop; other site
661410000120	H-loop/switch region; other site
661410000121	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
661410000122	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
661410000123	TM-ABC transporter signature motif; other site
661410000124	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
661410000125	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
661410000126	TM-ABC transporter signature motif; other site
661410000127	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
661410000128	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330
661410000129	putative ligand binding site [chemical binding]; other site
661410000130	Transcriptional regulator [Transcription]; Region: IclR; COG1414
661410000131	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
661410000132	Bacterial transcriptional regulator; Region: IclR; pfam01614
661410000133	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
661410000134	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
661410000135	Phasin protein; Region: Phasin_2; cl11491
661410000136	HTH-like domain; Region: HTH_21; pfam13276
661410000137	Integrase core domain; Region: rve; pfam00665
661410000138	Integrase core domain; Region: rve_3; pfam13683
661410000139	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
661410000140	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
661410000141	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
661410000142	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
661410000143	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410000144	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
661410000145	dimerization interface [polypeptide binding]; other site
661410000146	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
661410000147	EamA-like transporter family; Region: EamA; pfam00892
661410000148	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
661410000149	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
661410000150	putative NAD(P) binding site [chemical binding]; other site
661410000151	dimer interface [polypeptide binding]; other site
661410000152	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410000153	GAF domain; Region: GAF; pfam01590
661410000154	PAS domain; Region: PAS_9; pfam13426
661410000155	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410000156	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410000157	metal binding site [ion binding]; metal-binding site
661410000158	active site
661410000159	I-site; other site
661410000160	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
661410000161	Transposase; Region: DEDD_Tnp_IS110; pfam01548
661410000162	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
661410000163	Abi-like protein; Region: Abi_2; pfam07751
661410000164	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
661410000165	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
661410000166	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
661410000167	putative active site [active]
661410000168	Uncharacterized conserved protein [Function unknown]; Region: COG5489
661410000169	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
661410000170	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
661410000171	peptide synthase; Validated; Region: PRK05691
661410000172	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
661410000173	ParB-like nuclease domain; Region: ParBc; pfam02195
661410000174	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410000175	S-adenosylmethionine binding site [chemical binding]; other site
661410000176	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
661410000177	Helicase_C-like; Region: Helicase_C_4; pfam13871
661410000178	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
661410000179	active site
661410000180	metal binding site [ion binding]; metal-binding site
661410000181	interdomain interaction site; other site
661410000182	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
661410000183	conjugal transfer coupling protein TraG; Provisional; Region: PRK13822
661410000184	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
661410000185	Walker A motif; other site
661410000186	ATP binding site [chemical binding]; other site
661410000187	Walker B motif; other site
661410000188	Conjugal transfer protein TraD; Region: TraD; cl05753
661410000189	TraC-like protein; Region: TraC; cl06725
661410000190	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
661410000191	MobA/MobL family; Region: MobA_MobL; pfam03389
661410000192	AAA domain; Region: AAA_30; pfam13604
661410000193	Family description; Region: UvrD_C_2; pfam13538
661410000194	Fic/DOC family; Region: Fic; cl00960
661410000195	AAA-like domain; Region: AAA_10; pfam12846
661410000196	Protein of unknown function (DUF3625); Region: DUF3625; pfam12293
661410000197	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
661410000198	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
661410000199	Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524
661410000200	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
661410000201	Walker A motif; other site
661410000202	ATP binding site [chemical binding]; other site
661410000203	Walker B motif; other site
661410000204	Peptidase M15; Region: Peptidase_M15_3; cl01194
661410000205	DnaA N-terminal domain; Region: DnaA_N; pfam11638
661410000206	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
661410000207	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
661410000208	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
661410000209	DnaA box-binding interface [nucleotide binding]; other site
661410000210	DNA polymerase III subunit beta; Validated; Region: PRK05643
661410000211	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
661410000212	putative DNA binding surface [nucleotide binding]; other site
661410000213	dimer interface [polypeptide binding]; other site
661410000214	beta-clamp/clamp loader binding surface; other site
661410000215	beta-clamp/translesion DNA polymerase binding surface; other site
661410000216	recombination protein F; Reviewed; Region: recF; PRK00064
661410000217	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410000218	Walker A/P-loop; other site
661410000219	ATP binding site [chemical binding]; other site
661410000220	Q-loop/lid; other site
661410000221	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410000222	ABC transporter signature motif; other site
661410000223	Walker B; other site
661410000224	D-loop; other site
661410000225	H-loop/switch region; other site
661410000226	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
661410000227	putative active site [active]
661410000228	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
661410000229	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
661410000230	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
661410000231	ATP binding site [chemical binding]; other site
661410000232	putative Mg++ binding site [ion binding]; other site
661410000233	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
661410000234	nucleotide binding region [chemical binding]; other site
661410000235	ATP-binding site [chemical binding]; other site
661410000236	RQC domain; Region: RQC; pfam09382
661410000237	HRDC domain; Region: HRDC; pfam00570
661410000238	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
661410000239	AAA domain; Region: AAA_30; pfam13604
661410000240	Family description; Region: UvrD_C_2; pfam13538
661410000241	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
661410000242	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
661410000243	dimerization interface [polypeptide binding]; other site
661410000244	ATP binding site [chemical binding]; other site
661410000245	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
661410000246	dimerization interface [polypeptide binding]; other site
661410000247	ATP binding site [chemical binding]; other site
661410000248	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
661410000249	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
661410000250	putative GSH binding site [chemical binding]; other site
661410000251	catalytic residues [active]
661410000252	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
661410000253	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
661410000254	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
661410000255	PAS fold; Region: PAS_3; pfam08447
661410000256	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
661410000257	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410000258	dimer interface [polypeptide binding]; other site
661410000259	phosphorylation site [posttranslational modification]
661410000260	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410000261	ATP binding site [chemical binding]; other site
661410000262	Mg2+ binding site [ion binding]; other site
661410000263	G-X-G motif; other site
661410000264	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410000265	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410000266	active site
661410000267	phosphorylation site [posttranslational modification]
661410000268	intermolecular recognition site; other site
661410000269	dimerization interface [polypeptide binding]; other site
661410000270	circadian clock protein KaiC; Reviewed; Region: PRK09302
661410000271	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
661410000272	Walker A motif; other site
661410000273	ATP binding site [chemical binding]; other site
661410000274	Walker B motif; other site
661410000275	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
661410000276	ATP binding site [chemical binding]; other site
661410000277	Walker A motif; other site
661410000278	Walker B motif; other site
661410000279	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
661410000280	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
661410000281	short chain dehydrogenase; Provisional; Region: PRK06181
661410000282	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
661410000283	putative NAD(P) binding site [chemical binding]; other site
661410000284	active site
661410000285	Transcriptional regulators [Transcription]; Region: GntR; COG1802
661410000286	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
661410000287	DNA-binding site [nucleotide binding]; DNA binding site
661410000288	FCD domain; Region: FCD; pfam07729
661410000289	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
661410000290	Coenzyme A transferase; Region: CoA_trans; cl17247
661410000291	malonate decarboxylase subunit delta; Provisional; Region: PRK02103
661410000292	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
661410000293	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
661410000294	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
661410000295	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK02098
661410000296	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874
661410000297	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
661410000298	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
661410000299	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
661410000300	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
661410000301	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
661410000302	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
661410000303	general secretion pathway protein J; Validated; Region: PRK08808
661410000304	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
661410000305	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
661410000306	Integrase core domain; Region: rve_3; pfam13683
661410000307	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
661410000308	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
661410000309	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
661410000310	Domain of unknown function (DUF1971); Region: DUF1971; pfam09313
661410000311	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
661410000312	active site
661410000313	catalytic residues [active]
661410000314	DNA binding site [nucleotide binding]
661410000315	Int/Topo IB signature motif; other site
661410000316	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410000317	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410000318	ligand binding site [chemical binding]; other site
661410000319	flexible hinge region; other site
661410000320	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
661410000321	putative switch regulator; other site
661410000322	non-specific DNA interactions [nucleotide binding]; other site
661410000323	DNA binding site [nucleotide binding]
661410000324	sequence specific DNA binding site [nucleotide binding]; other site
661410000325	putative cAMP binding site [chemical binding]; other site
661410000326	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410000327	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410000328	ligand binding site [chemical binding]; other site
661410000329	flexible hinge region; other site
661410000330	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
661410000331	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
661410000332	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
661410000333	active site
661410000334	catalytic residues [active]
661410000335	DNA binding site [nucleotide binding]
661410000336	Int/Topo IB signature motif; other site
661410000337	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
661410000338	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
661410000339	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410000340	catalytic residue [active]
661410000341	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
661410000342	active site
661410000343	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
661410000344	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
661410000345	IHF dimer interface [polypeptide binding]; other site
661410000346	IHF - DNA interface [nucleotide binding]; other site
661410000347	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
661410000348	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
661410000349	tandem repeat interface [polypeptide binding]; other site
661410000350	oligomer interface [polypeptide binding]; other site
661410000351	active site residues [active]
661410000352	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
661410000353	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
661410000354	RNA binding site [nucleotide binding]; other site
661410000355	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
661410000356	RNA binding site [nucleotide binding]; other site
661410000357	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
661410000358	RNA binding site [nucleotide binding]; other site
661410000359	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
661410000360	RNA binding site [nucleotide binding]; other site
661410000361	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
661410000362	RNA binding site [nucleotide binding]; other site
661410000363	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
661410000364	RNA binding site [nucleotide binding]; other site
661410000365	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
661410000366	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
661410000367	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
661410000368	Class I aldolases; Region: Aldolase_Class_I; cl17187
661410000369	Pirin-related protein [General function prediction only]; Region: COG1741
661410000370	Pirin; Region: Pirin; pfam02678
661410000371	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
661410000372	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
661410000373	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
661410000374	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
661410000375	TrkA-N domain; Region: TrkA_N; pfam02254
661410000376	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
661410000377	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
661410000378	minor groove reading motif; other site
661410000379	helix-hairpin-helix signature motif; other site
661410000380	substrate binding pocket [chemical binding]; other site
661410000381	active site
661410000382	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
661410000383	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410000384	dimer interface [polypeptide binding]; other site
661410000385	putative CheW interface [polypeptide binding]; other site
661410000386	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
661410000387	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410000388	Walker A/P-loop; other site
661410000389	ATP binding site [chemical binding]; other site
661410000390	Q-loop/lid; other site
661410000391	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
661410000392	ABC transporter signature motif; other site
661410000393	Walker B; other site
661410000394	D-loop; other site
661410000395	ABC transporter; Region: ABC_tran_2; pfam12848
661410000396	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
661410000397	Protein of unknown function (DUF419); Region: DUF419; pfam04237
661410000398	Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777
661410000399	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
661410000400	active site
661410000401	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
661410000402	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410000403	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
661410000404	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410000405	putative ADP-binding pocket [chemical binding]; other site
661410000406	sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472
661410000407	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
661410000408	putative ADP-binding pocket [chemical binding]; other site
661410000409	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
661410000410	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
661410000411	active site
661410000412	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
661410000413	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
661410000414	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
661410000415	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
661410000416	active site
661410000417	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410000418	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
661410000419	putative ADP-binding pocket [chemical binding]; other site
661410000420	Methyltransferase domain; Region: Methyltransf_24; pfam13578
661410000421	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
661410000422	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410000423	active site
661410000424	phosphorylation site [posttranslational modification]
661410000425	intermolecular recognition site; other site
661410000426	dimerization interface [polypeptide binding]; other site
661410000427	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
661410000428	Zn2+ binding site [ion binding]; other site
661410000429	Mg2+ binding site [ion binding]; other site
661410000430	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
661410000431	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410000432	Walker A/P-loop; other site
661410000433	ATP binding site [chemical binding]; other site
661410000434	Q-loop/lid; other site
661410000435	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410000436	ABC transporter signature motif; other site
661410000437	Walker B; other site
661410000438	D-loop; other site
661410000439	H-loop/switch region; other site
661410000440	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410000441	Walker A/P-loop; other site
661410000442	ATP binding site [chemical binding]; other site
661410000443	Q-loop/lid; other site
661410000444	ABC transporter signature motif; other site
661410000445	Walker B; other site
661410000446	D-loop; other site
661410000447	H-loop/switch region; other site
661410000448	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
661410000449	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
661410000450	conserved cys residue [active]
661410000451	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
661410000452	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
661410000453	classical (c) SDRs; Region: SDR_c; cd05233
661410000454	NAD(P) binding site [chemical binding]; other site
661410000455	active site
661410000456	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
661410000457	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
661410000458	catalytic loop [active]
661410000459	iron binding site [ion binding]; other site
661410000460	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
661410000461	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
661410000462	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
661410000463	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
661410000464	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
661410000465	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
661410000466	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323
661410000467	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
661410000468	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
661410000469	ligand binding site [chemical binding]; other site
661410000470	NAD binding site [chemical binding]; other site
661410000471	tetramer interface [polypeptide binding]; other site
661410000472	catalytic site [active]
661410000473	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
661410000474	L-serine binding site [chemical binding]; other site
661410000475	ACT domain interface; other site
661410000476	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
661410000477	FAD binding domain; Region: FAD_binding_4; pfam01565
661410000478	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
661410000479	heme-binding residues [chemical binding]; other site
661410000480	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
661410000481	molybdopterin cofactor binding site; other site
661410000482	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
661410000483	4Fe-4S binding domain; Region: Fer4_2; pfam12797
661410000484	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
661410000485	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
661410000486	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
661410000487	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
661410000488	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
661410000489	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
661410000490	Cytochrome c; Region: Cytochrom_C; pfam00034
661410000491	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
661410000492	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
661410000493	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
661410000494	Subunit I/III interface [polypeptide binding]; other site
661410000495	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
661410000496	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
661410000497	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
661410000498	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
661410000499	DNA binding residues [nucleotide binding]
661410000500	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
661410000501	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
661410000502	putative heme binding pocket [chemical binding]; other site
661410000503	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
661410000504	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
661410000505	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
661410000506	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
661410000507	Soluble P-type ATPase [General function prediction only]; Region: COG4087
661410000508	potassium-transporting ATPase subunit C; Provisional; Region: PRK13999
661410000509	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
661410000510	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
661410000511	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
661410000512	Ligand Binding Site [chemical binding]; other site
661410000513	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410000514	dimer interface [polypeptide binding]; other site
661410000515	phosphorylation site [posttranslational modification]
661410000516	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410000517	ATP binding site [chemical binding]; other site
661410000518	Mg2+ binding site [ion binding]; other site
661410000519	G-X-G motif; other site
661410000520	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
661410000521	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410000522	active site
661410000523	phosphorylation site [posttranslational modification]
661410000524	intermolecular recognition site; other site
661410000525	dimerization interface [polypeptide binding]; other site
661410000526	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410000527	DNA binding site [nucleotide binding]
661410000528	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
661410000529	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
661410000530	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
661410000531	Methyltransferase domain; Region: Methyltransf_23; pfam13489
661410000532	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410000533	S-adenosylmethionine binding site [chemical binding]; other site
661410000534	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
661410000535	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
661410000536	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
661410000537	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
661410000538	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
661410000539	NAD binding site [chemical binding]; other site
661410000540	putative substrate binding site 2 [chemical binding]; other site
661410000541	putative substrate binding site 1 [chemical binding]; other site
661410000542	active site
661410000543	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
661410000544	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
661410000545	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
661410000546	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
661410000547	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
661410000548	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
661410000549	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
661410000550	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410000551	B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295
661410000552	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
661410000553	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410000554	FeS/SAM binding site; other site
661410000555	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410000556	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
661410000557	NAD(P) binding site [chemical binding]; other site
661410000558	active site
661410000559	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
661410000560	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410000561	NAD(P) binding site [chemical binding]; other site
661410000562	active site
661410000563	Transposase; Region: HTH_Tnp_1; pfam01527
661410000564	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
661410000565	HTH-like domain; Region: HTH_21; pfam13276
661410000566	Integrase core domain; Region: rve; pfam00665
661410000567	Integrase core domain; Region: rve_3; pfam13683
661410000568	Transposase; Region: DEDD_Tnp_IS110; pfam01548
661410000569	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
661410000570	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
661410000571	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
661410000572	Catalytic site [active]
661410000573	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
661410000574	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
661410000575	active site
661410000576	DNA binding site [nucleotide binding]
661410000577	recombination factor protein RarA; Reviewed; Region: PRK13342
661410000578	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410000579	Walker A motif; other site
661410000580	ATP binding site [chemical binding]; other site
661410000581	Walker B motif; other site
661410000582	arginine finger; other site
661410000583	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
661410000584	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
661410000585	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
661410000586	active site
661410000587	Zn binding site [ion binding]; other site
661410000588	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
661410000589	putative chaperone; Provisional; Region: PRK11678
661410000590	nucleotide binding site [chemical binding]; other site
661410000591	putative NEF/HSP70 interaction site [polypeptide binding]; other site
661410000592	SBD interface [polypeptide binding]; other site
661410000593	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
661410000594	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
661410000595	RNA binding surface [nucleotide binding]; other site
661410000596	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
661410000597	active site
661410000598	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
661410000599	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
661410000600	motif II; other site
661410000601	ATP12 chaperone protein; Region: ATP12; cl02228
661410000602	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
661410000603	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
661410000604	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
661410000605	tellurium resistance terB-like protein; Region: terB_like; cd07177
661410000606	metal binding site [ion binding]; metal-binding site
661410000607	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
661410000608	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
661410000609	ketol-acid reductoisomerase; Provisional; Region: PRK05479
661410000610	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
661410000611	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
661410000612	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
661410000613	Methyltransferase domain; Region: Methyltransf_24; pfam13578
661410000614	crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246
661410000615	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
661410000616	putative NAD(P) binding site [chemical binding]; other site
661410000617	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
661410000618	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
661410000619	tetramer interface [polypeptide binding]; other site
661410000620	heme binding pocket [chemical binding]; other site
661410000621	NADPH binding site [chemical binding]; other site
661410000622	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, MeaA-like subfamily; contains various methylmalonyl coenzyme A (CoA) mutase (MCM)-like proteins similar to the Streptomyces cinnamonensis MeaA, Methylobacterium extorquens MeaA...; Region: MM_CoA_mutase_MeaA; cd03681
661410000623	putative active site [active]
661410000624	putative substrate binding site [chemical binding]; other site
661410000625	putative coenzyme B12 binding site [chemical binding]; other site
661410000626	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
661410000627	B12 binding site [chemical binding]; other site
661410000628	cobalt ligand [ion binding]; other site
661410000629	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
661410000630	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
661410000631	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410000632	NAD(P) binding site [chemical binding]; other site
661410000633	active site
661410000634	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
661410000635	dimerization interface [polypeptide binding]; other site
661410000636	putative DNA binding site [nucleotide binding]; other site
661410000637	putative Zn2+ binding site [ion binding]; other site
661410000638	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
661410000639	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
661410000640	active site
661410000641	HIGH motif; other site
661410000642	dimer interface [polypeptide binding]; other site
661410000643	KMSKS motif; other site
661410000644	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
661410000645	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
661410000646	substrate binding site [chemical binding]; other site
661410000647	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
661410000648	putative substrate binding pocket [chemical binding]; other site
661410000649	AC domain interface; other site
661410000650	catalytic triad [active]
661410000651	AB domain interface; other site
661410000652	membrane ATPase/protein kinase; Provisional; Region: PRK09435
661410000653	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
661410000654	Walker A; other site
661410000655	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
661410000656	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
661410000657	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
661410000658	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
661410000659	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410000660	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
661410000661	active site
661410000662	metal binding site [ion binding]; metal-binding site
661410000663	DNA binding site [nucleotide binding]
661410000664	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410000665	Walker A/P-loop; other site
661410000666	ATP binding site [chemical binding]; other site
661410000667	Q-loop/lid; other site
661410000668	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410000669	ABC transporter signature motif; other site
661410000670	Walker B; other site
661410000671	D-loop; other site
661410000672	H-loop/switch region; other site
661410000673	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
661410000674	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410000675	putative substrate translocation pore; other site
661410000676	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
661410000677	Methyltransferase domain; Region: Methyltransf_11; pfam08241
661410000678	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
661410000679	Domain of unknown function (DUF427); Region: DUF427; pfam04248
661410000680	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
661410000681	active site
661410000682	8-oxo-dGMP binding site [chemical binding]; other site
661410000683	nudix motif; other site
661410000684	metal binding site [ion binding]; metal-binding site
661410000685	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
661410000686	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
661410000687	heterotetramer interface [polypeptide binding]; other site
661410000688	active site pocket [active]
661410000689	cleavage site
661410000690	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
661410000691	catalytic residues [active]
661410000692	dimer interface [polypeptide binding]; other site
661410000693	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
661410000694	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
661410000695	Proline dehydrogenase; Region: Pro_dh; pfam01619
661410000696	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
661410000697	Glutamate binding site [chemical binding]; other site
661410000698	NAD binding site [chemical binding]; other site
661410000699	catalytic residues [active]
661410000700	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
661410000701	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
661410000702	Part of AAA domain; Region: AAA_19; pfam13245
661410000703	Family description; Region: UvrD_C_2; pfam13538
661410000704	PhoH-like protein; Region: PhoH; pfam02562
661410000705	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
661410000706	amphipathic channel; other site
661410000707	Asn-Pro-Ala signature motifs; other site
661410000708	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
661410000709	active site
661410000710	catalytic site [active]
661410000711	substrate binding site [chemical binding]; other site
661410000712	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
661410000713	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
661410000714	metal binding triad; other site
661410000715	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
661410000716	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
661410000717	metal binding triad; other site
661410000718	Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298
661410000719	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
661410000720	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410000721	dimerization interface [polypeptide binding]; other site
661410000722	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410000723	dimer interface [polypeptide binding]; other site
661410000724	phosphorylation site [posttranslational modification]
661410000725	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410000726	ATP binding site [chemical binding]; other site
661410000727	Mg2+ binding site [ion binding]; other site
661410000728	G-X-G motif; other site
661410000729	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
661410000730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410000731	active site
661410000732	phosphorylation site [posttranslational modification]
661410000733	intermolecular recognition site; other site
661410000734	dimerization interface [polypeptide binding]; other site
661410000735	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410000736	DNA binding site [nucleotide binding]
661410000737	OsmC-like protein; Region: OsmC; pfam02566
661410000738	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
661410000739	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
661410000740	Walker A/P-loop; other site
661410000741	ATP binding site [chemical binding]; other site
661410000742	Q-loop/lid; other site
661410000743	ABC transporter signature motif; other site
661410000744	Walker B; other site
661410000745	D-loop; other site
661410000746	H-loop/switch region; other site
661410000747	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
661410000748	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
661410000749	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
661410000750	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
661410000751	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
661410000752	substrate binding pocket [chemical binding]; other site
661410000753	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
661410000754	membrane-bound complex binding site; other site
661410000755	PII uridylyl-transferase; Provisional; Region: PRK05092
661410000756	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
661410000757	metal binding triad; other site
661410000758	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
661410000759	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
661410000760	Zn2+ binding site [ion binding]; other site
661410000761	Mg2+ binding site [ion binding]; other site
661410000762	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
661410000763	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
661410000764	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
661410000765	dimer interface [polypeptide binding]; other site
661410000766	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
661410000767	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
661410000768	Protein of unknown function (DUF497); Region: DUF497; cl01108
661410000769	prephenate dehydratase; Provisional; Region: PRK11899
661410000770	Prephenate dehydratase; Region: PDT; pfam00800
661410000771	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
661410000772	putative L-Phe binding site [chemical binding]; other site
661410000773	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
661410000774	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
661410000775	active site
661410000776	Cytochrome c2 [Energy production and conversion]; Region: COG3474
661410000777	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
661410000778	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
661410000779	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
661410000780	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
661410000781	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
661410000782	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410000783	dimer interface [polypeptide binding]; other site
661410000784	conserved gate region; other site
661410000785	putative PBP binding loops; other site
661410000786	ABC-ATPase subunit interface; other site
661410000787	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
661410000788	Coenzyme A binding pocket [chemical binding]; other site
661410000789	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
661410000790	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
661410000791	acyl-activating enzyme (AAE) consensus motif; other site
661410000792	AMP binding site [chemical binding]; other site
661410000793	active site
661410000794	CoA binding site [chemical binding]; other site
661410000795	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
661410000796	putative metal binding site; other site
661410000797	HNH endonuclease; Region: HNH_3; pfam13392
661410000798	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410000799	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
661410000800	Walker A motif; other site
661410000801	ATP binding site [chemical binding]; other site
661410000802	Walker B motif; other site
661410000803	arginine finger; other site
661410000804	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
661410000805	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
661410000806	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
661410000807	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410000808	ATP binding site [chemical binding]; other site
661410000809	Mg2+ binding site [ion binding]; other site
661410000810	G-X-G motif; other site
661410000811	Response regulator receiver domain; Region: Response_reg; pfam00072
661410000812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410000813	active site
661410000814	phosphorylation site [posttranslational modification]
661410000815	intermolecular recognition site; other site
661410000816	dimerization interface [polypeptide binding]; other site
661410000817	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410000818	GAF domain; Region: GAF; pfam01590
661410000819	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410000820	Histidine kinase; Region: HisKA_2; pfam07568
661410000821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410000822	ATP binding site [chemical binding]; other site
661410000823	Mg2+ binding site [ion binding]; other site
661410000824	G-X-G motif; other site
661410000825	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
661410000826	active site
661410000827	metal binding site [ion binding]; metal-binding site
661410000828	Cache domain; Region: Cache_1; pfam02743
661410000829	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410000830	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410000831	metal binding site [ion binding]; metal-binding site
661410000832	active site
661410000833	I-site; other site
661410000834	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410000835	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410000836	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
661410000837	dimerization interface [polypeptide binding]; other site
661410000838	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
661410000839	Protein export membrane protein; Region: SecD_SecF; cl14618
661410000840	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
661410000841	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410000842	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410000843	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410000844	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
661410000845	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
661410000846	putative dimer interface [polypeptide binding]; other site
661410000847	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410000848	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410000849	ligand binding site [chemical binding]; other site
661410000850	flexible hinge region; other site
661410000851	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
661410000852	putative switch regulator; other site
661410000853	non-specific DNA interactions [nucleotide binding]; other site
661410000854	DNA binding site [nucleotide binding]
661410000855	sequence specific DNA binding site [nucleotide binding]; other site
661410000856	putative cAMP binding site [chemical binding]; other site
661410000857	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410000858	Ligand Binding Site [chemical binding]; other site
661410000859	Cytochrome c; Region: Cytochrom_C; cl11414
661410000860	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
661410000861	E3 interaction surface; other site
661410000862	lipoyl attachment site [posttranslational modification]; other site
661410000863	Ion channel; Region: Ion_trans_2; pfam07885
661410000864	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
661410000865	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
661410000866	response regulator; Provisional; Region: PRK13435
661410000867	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
661410000868	BON domain; Region: BON; pfam04972
661410000869	BON domain; Region: BON; pfam04972
661410000870	BON domain; Region: BON; pfam04972
661410000871	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410000872	Ligand Binding Site [chemical binding]; other site
661410000873	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410000874	Ligand Binding Site [chemical binding]; other site
661410000875	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
661410000876	Cytochrome c; Region: Cytochrom_C; pfam00034
661410000877	Universal stress protein family; Region: Usp; pfam00582
661410000878	Ligand Binding Site [chemical binding]; other site
661410000879	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410000880	Ligand Binding Site [chemical binding]; other site
661410000881	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
661410000882	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
661410000883	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
661410000884	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
661410000885	putative NAD(P) binding site [chemical binding]; other site
661410000886	putative substrate binding site [chemical binding]; other site
661410000887	catalytic Zn binding site [ion binding]; other site
661410000888	structural Zn binding site [ion binding]; other site
661410000889	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
661410000890	BON domain; Region: BON; pfam04972
661410000891	BON domain; Region: BON; pfam04972
661410000892	BON domain; Region: BON; pfam04972
661410000893	putative phosphoketolase; Provisional; Region: PRK05261
661410000894	XFP N-terminal domain; Region: XFP_N; pfam09364
661410000895	XFP C-terminal domain; Region: XFP_C; pfam09363
661410000896	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
661410000897	Clp amino terminal domain; Region: Clp_N; pfam02861
661410000898	Clp amino terminal domain; Region: Clp_N; pfam02861
661410000899	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410000900	Walker A motif; other site
661410000901	ATP binding site [chemical binding]; other site
661410000902	Walker B motif; other site
661410000903	arginine finger; other site
661410000904	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410000905	Walker A motif; other site
661410000906	ATP binding site [chemical binding]; other site
661410000907	Walker B motif; other site
661410000908	arginine finger; other site
661410000909	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
661410000910	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
661410000911	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
661410000912	HSP70 interaction site [polypeptide binding]; other site
661410000913	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
661410000914	substrate binding site [polypeptide binding]; other site
661410000915	dimer interface [polypeptide binding]; other site
661410000916	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
661410000917	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
661410000918	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
661410000919	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
661410000920	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
661410000921	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
661410000922	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
661410000923	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410000924	NAD(P) binding site [chemical binding]; other site
661410000925	active site
661410000926	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
661410000927	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
661410000928	dimer interaction site [polypeptide binding]; other site
661410000929	substrate-binding tunnel; other site
661410000930	active site
661410000931	catalytic site [active]
661410000932	substrate binding site [chemical binding]; other site
661410000933	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
661410000934	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
661410000935	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
661410000936	BON domain; Region: BON; pfam04972
661410000937	BON domain; Region: BON; pfam04972
661410000938	BON domain; Region: BON; pfam04972
661410000939	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
661410000940	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
661410000941	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
661410000942	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
661410000943	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
661410000944	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
661410000945	motif II; other site
661410000946	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
661410000947	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410000948	Ligand Binding Site [chemical binding]; other site
661410000949	DDE superfamily endonuclease; Region: DDE_3; pfam13358
661410000950	Winged helix-turn helix; Region: HTH_29; pfam13551
661410000951	Homeodomain-like domain; Region: HTH_32; pfam13565
661410000952	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410000953	ligand binding site [chemical binding]; other site
661410000954	flexible hinge region; other site
661410000955	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
661410000956	putative switch regulator; other site
661410000957	non-specific DNA interactions [nucleotide binding]; other site
661410000958	DNA binding site [nucleotide binding]
661410000959	sequence specific DNA binding site [nucleotide binding]; other site
661410000960	putative cAMP binding site [chemical binding]; other site
661410000961	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
661410000962	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
661410000963	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
661410000964	Winged helix-turn helix; Region: HTH_29; pfam13551
661410000965	Transposase; Region: HTH_Tnp_1; cl17663
661410000966	Integrase core domain; Region: rve; pfam00665
661410000967	Integrase core domain; Region: rve_3; pfam13683
661410000968	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
661410000969	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
661410000970	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
661410000971	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410000972	active site
661410000973	phosphorylation site [posttranslational modification]
661410000974	intermolecular recognition site; other site
661410000975	dimerization interface [polypeptide binding]; other site
661410000976	response regulator FixJ; Provisional; Region: fixJ; PRK09390
661410000977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410000978	active site
661410000979	phosphorylation site [posttranslational modification]
661410000980	intermolecular recognition site; other site
661410000981	dimerization interface [polypeptide binding]; other site
661410000982	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
661410000983	DNA binding residues [nucleotide binding]
661410000984	dimerization interface [polypeptide binding]; other site
661410000985	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410000986	PAS fold; Region: PAS_3; pfam08447
661410000987	putative active site [active]
661410000988	heme pocket [chemical binding]; other site
661410000989	PAS domain S-box; Region: sensory_box; TIGR00229
661410000990	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410000991	putative active site [active]
661410000992	heme pocket [chemical binding]; other site
661410000993	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410000994	dimer interface [polypeptide binding]; other site
661410000995	phosphorylation site [posttranslational modification]
661410000996	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410000997	ATP binding site [chemical binding]; other site
661410000998	Mg2+ binding site [ion binding]; other site
661410000999	G-X-G motif; other site
661410001000	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410001001	Ligand Binding Site [chemical binding]; other site
661410001002	Cytochrome c; Region: Cytochrom_C; pfam00034
661410001003	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410001004	Ligand Binding Site [chemical binding]; other site
661410001005	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410001006	Ligand Binding Site [chemical binding]; other site
661410001007	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
661410001008	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
661410001009	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
661410001010	Integrase core domain; Region: rve; pfam00665
661410001011	Integrase core domain; Region: rve_3; pfam13683
661410001012	PAS domain; Region: PAS_9; pfam13426
661410001013	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410001014	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410001015	metal binding site [ion binding]; metal-binding site
661410001016	active site
661410001017	I-site; other site
661410001018	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410001019	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
661410001020	Ca2+ binding site [ion binding]; other site
661410001021	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
661410001022	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410001023	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
661410001024	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
661410001025	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
661410001026	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
661410001027	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
661410001028	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
661410001029	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
661410001030	dimerization interface [polypeptide binding]; other site
661410001031	putative DNA binding site [nucleotide binding]; other site
661410001032	putative Zn2+ binding site [ion binding]; other site
661410001033	sensor protein QseC; Provisional; Region: PRK10337
661410001034	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410001035	dimer interface [polypeptide binding]; other site
661410001036	phosphorylation site [posttranslational modification]
661410001037	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410001038	ATP binding site [chemical binding]; other site
661410001039	Mg2+ binding site [ion binding]; other site
661410001040	G-X-G motif; other site
661410001041	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
661410001042	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410001043	active site
661410001044	phosphorylation site [posttranslational modification]
661410001045	intermolecular recognition site; other site
661410001046	dimerization interface [polypeptide binding]; other site
661410001047	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410001048	DNA binding site [nucleotide binding]
661410001049	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
661410001050	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
661410001051	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
661410001052	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
661410001053	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
661410001054	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
661410001055	catalytic residues [active]
661410001056	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
661410001057	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410001058	DsrE/DsrF-like family; Region: DrsE; cl00672
661410001059	Predicted transporter component [General function prediction only]; Region: COG2391
661410001060	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
661410001061	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
661410001062	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
661410001063	catalytic residues [active]
661410001064	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
661410001065	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
661410001066	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
661410001067	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
661410001068	dimerization interface [polypeptide binding]; other site
661410001069	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410001070	dimer interface [polypeptide binding]; other site
661410001071	putative CheW interface [polypeptide binding]; other site
661410001072	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
661410001073	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
661410001074	Walker A/P-loop; other site
661410001075	ATP binding site [chemical binding]; other site
661410001076	Q-loop/lid; other site
661410001077	ABC transporter signature motif; other site
661410001078	Walker B; other site
661410001079	D-loop; other site
661410001080	H-loop/switch region; other site
661410001081	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
661410001082	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
661410001083	substrate binding pocket [chemical binding]; other site
661410001084	membrane-bound complex binding site; other site
661410001085	hinge residues; other site
661410001086	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
661410001087	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410001088	dimer interface [polypeptide binding]; other site
661410001089	conserved gate region; other site
661410001090	putative PBP binding loops; other site
661410001091	ABC-ATPase subunit interface; other site
661410001092	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
661410001093	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
661410001094	NAD binding site [chemical binding]; other site
661410001095	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410001096	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410001097	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
661410001098	dimerization interface [polypeptide binding]; other site
661410001099	Cytochrome c; Region: Cytochrom_C; cl11414
661410001100	Cytochrome c; Region: Cytochrom_C; cl11414
661410001101	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
661410001102	ba3-like heme-copper oxidase subunit I.  The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660
661410001103	Putative D-pathway homolog; other site
661410001104	Low-spin heme binding site [chemical binding]; other site
661410001105	Subunit I/II interface [polypeptide binding]; other site
661410001106	Putative Q-pathway; other site
661410001107	Putative alternate electron transfer pathway; other site
661410001108	Putative water exit pathway; other site
661410001109	Binuclear center (active site) [active]
661410001110	Putative K-pathway homolog; other site
661410001111	Putative proton exit pathway; other site
661410001112	Subunit I/IIa interface [polypeptide binding]; other site
661410001113	Electron transfer pathway; other site
661410001114	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
661410001115	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
661410001116	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
661410001117	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
661410001118	Cytochrome c; Region: Cytochrom_C; pfam00034
661410001119	Cytochrome c; Region: Cytochrom_C; cl11414
661410001120	Cytochrome c; Region: Cytochrom_C; cl11414
661410001121	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410001122	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410001123	ligand binding site [chemical binding]; other site
661410001124	flexible hinge region; other site
661410001125	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
661410001126	putative switch regulator; other site
661410001127	non-specific DNA interactions [nucleotide binding]; other site
661410001128	DNA binding site [nucleotide binding]
661410001129	sequence specific DNA binding site [nucleotide binding]; other site
661410001130	putative cAMP binding site [chemical binding]; other site
661410001131	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410001132	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410001133	active site
661410001134	phosphorylation site [posttranslational modification]
661410001135	intermolecular recognition site; other site
661410001136	dimerization interface [polypeptide binding]; other site
661410001137	Uncharacterized conserved protein [Function unknown]; Region: COG1359
661410001138	short chain dehydrogenase; Provisional; Region: PRK06500
661410001139	classical (c) SDRs; Region: SDR_c; cd05233
661410001140	NAD(P) binding site [chemical binding]; other site
661410001141	active site
661410001142	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
661410001143	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
661410001144	active site
661410001145	catalytic tetrad [active]
661410001146	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410001147	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410001148	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
661410001149	putative effector binding pocket; other site
661410001150	putative dimerization interface [polypeptide binding]; other site
661410001151	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
661410001152	active site
661410001153	iron coordination sites [ion binding]; other site
661410001154	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
661410001155	Sulfate transporter family; Region: Sulfate_transp; pfam00916
661410001156	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
661410001157	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
661410001158	putative active site [active]
661410001159	Zn binding site [ion binding]; other site
661410001160	Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; pfam09250
661410001161	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
661410001162	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410001163	Walker A motif; other site
661410001164	ATP binding site [chemical binding]; other site
661410001165	Walker B motif; other site
661410001166	arginine finger; other site
661410001167	Peptidase family M41; Region: Peptidase_M41; pfam01434
661410001168	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
661410001169	active site
661410001170	metal binding site [ion binding]; metal-binding site
661410001171	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
661410001172	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
661410001173	DNA binding residues [nucleotide binding]
661410001174	Domain of unknown function (DUF955); Region: DUF955; pfam06114
661410001175	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
661410001176	Part of AAA domain; Region: AAA_19; pfam13245
661410001177	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
661410001178	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
661410001179	Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462
661410001180	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
661410001181	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
661410001182	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
661410001183	ATP binding site [chemical binding]; other site
661410001184	substrate interface [chemical binding]; other site
661410001185	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
661410001186	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
661410001187	putative active site [active]
661410001188	putative metal binding site [ion binding]; other site
661410001189	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
661410001190	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
661410001191	active site
661410001192	DNA binding site [nucleotide binding]
661410001193	Int/Topo IB signature motif; other site
661410001194	PAS domain; Region: PAS_9; pfam13426
661410001195	PAS domain S-box; Region: sensory_box; TIGR00229
661410001196	PAS domain S-box; Region: sensory_box; TIGR00229
661410001197	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410001198	putative active site [active]
661410001199	heme pocket [chemical binding]; other site
661410001200	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
661410001201	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
661410001202	DNA binding residues [nucleotide binding]
661410001203	dimerization interface [polypeptide binding]; other site
661410001204	CsbD-like; Region: CsbD; cl17424
661410001205	CsbD-like; Region: CsbD; pfam05532
661410001206	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
661410001207	CsbD-like; Region: CsbD; pfam05532
661410001208	CsbD-like; Region: CsbD; pfam05532
661410001209	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
661410001210	acetylornithine deacetylase; Provisional; Region: PRK07522
661410001211	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
661410001212	metal binding site [ion binding]; metal-binding site
661410001213	putative dimer interface [polypeptide binding]; other site
661410001214	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
661410001215	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
661410001216	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
661410001217	trimer interface [polypeptide binding]; other site
661410001218	active site
661410001219	Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717
661410001220	trimer interface [polypeptide binding]; other site
661410001221	active site
661410001222	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
661410001223	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
661410001224	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
661410001225	putative MPT binding site; other site
661410001226	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
661410001227	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
661410001228	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
661410001229	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
661410001230	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
661410001231	ABC-2 type transporter; Region: ABC2_membrane; cl17235
661410001232	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
661410001233	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
661410001234	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
661410001235	Walker A/P-loop; other site
661410001236	ATP binding site [chemical binding]; other site
661410001237	Q-loop/lid; other site
661410001238	ABC transporter signature motif; other site
661410001239	Walker B; other site
661410001240	D-loop; other site
661410001241	H-loop/switch region; other site
661410001242	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
661410001243	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
661410001244	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
661410001245	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
661410001246	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
661410001247	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
661410001248	formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811
661410001249	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
661410001250	[4Fe-4S] binding site [ion binding]; other site
661410001251	molybdopterin cofactor binding site; other site
661410001252	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
661410001253	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
661410001254	molybdopterin cofactor binding site; other site
661410001255	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
661410001256	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
661410001257	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
661410001258	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
661410001259	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
661410001260	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
661410001261	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
661410001262	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410001263	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410001264	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410001265	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
661410001266	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
661410001267	ribonuclease PH; Reviewed; Region: rph; PRK00173
661410001268	Ribonuclease PH; Region: RNase_PH_bact; cd11362
661410001269	hexamer interface [polypeptide binding]; other site
661410001270	active site
661410001271	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
661410001272	active site
661410001273	dimerization interface [polypeptide binding]; other site
661410001274	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
661410001275	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410001276	FeS/SAM binding site; other site
661410001277	HemN C-terminal domain; Region: HemN_C; pfam06969
661410001278	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
661410001279	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
661410001280	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
661410001281	putative ligand binding site [chemical binding]; other site
661410001282	Predicted methyltransferases [General function prediction only]; Region: COG0313
661410001283	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
661410001284	putative SAM binding site [chemical binding]; other site
661410001285	putative homodimer interface [polypeptide binding]; other site
661410001286	hypothetical protein; Provisional; Region: PRK14679
661410001287	Response regulator receiver domain; Region: Response_reg; pfam00072
661410001288	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410001289	active site
661410001290	phosphorylation site [posttranslational modification]
661410001291	intermolecular recognition site; other site
661410001292	dimerization interface [polypeptide binding]; other site
661410001293	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
661410001294	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
661410001295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410001296	putative PBP binding loops; other site
661410001297	ABC-ATPase subunit interface; other site
661410001298	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
661410001299	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
661410001300	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410001301	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
661410001302	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
661410001303	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
661410001304	active site
661410001305	Zn binding site [ion binding]; other site
661410001306	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
661410001307	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
661410001308	Potassium binding sites [ion binding]; other site
661410001309	Cesium cation binding sites [ion binding]; other site
661410001310	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
661410001311	metal-binding site [ion binding]
661410001312	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410001313	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
661410001314	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
661410001315	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410001316	active site
661410001317	phosphorylation site [posttranslational modification]
661410001318	intermolecular recognition site; other site
661410001319	dimerization interface [polypeptide binding]; other site
661410001320	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
661410001321	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
661410001322	active site
661410001323	Riboflavin kinase; Region: Flavokinase; pfam01687
661410001324	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
661410001325	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
661410001326	dimerization interface [polypeptide binding]; other site
661410001327	ligand binding site [chemical binding]; other site
661410001328	NADP binding site [chemical binding]; other site
661410001329	catalytic site [active]
661410001330	Bacterial SH3 domain; Region: SH3_4; pfam06347
661410001331	Bacterial SH3 domain; Region: SH3_4; pfam06347
661410001332	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
661410001333	metal binding site 2 [ion binding]; metal-binding site
661410001334	putative DNA binding helix; other site
661410001335	metal binding site 1 [ion binding]; metal-binding site
661410001336	dimer interface [polypeptide binding]; other site
661410001337	structural Zn2+ binding site [ion binding]; other site
661410001338	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
661410001339	active site 1 [active]
661410001340	dimer interface [polypeptide binding]; other site
661410001341	active site 2 [active]
661410001342	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
661410001343	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
661410001344	dimer interface [polypeptide binding]; other site
661410001345	active site
661410001346	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
661410001347	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
661410001348	NAD binding site [chemical binding]; other site
661410001349	homotetramer interface [polypeptide binding]; other site
661410001350	homodimer interface [polypeptide binding]; other site
661410001351	substrate binding site [chemical binding]; other site
661410001352	active site
661410001353	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
661410001354	Predicted membrane protein [Function unknown]; Region: COG2259
661410001355	hypothetical protein; Provisional; Region: PRK13663
661410001356	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
661410001357	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
661410001358	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
661410001359	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
661410001360	PAS domain S-box; Region: sensory_box; TIGR00229
661410001361	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410001362	putative active site [active]
661410001363	heme pocket [chemical binding]; other site
661410001364	Histidine kinase; Region: HisKA_2; pfam07568
661410001365	PAS fold; Region: PAS_4; pfam08448
661410001366	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410001367	PAS fold; Region: PAS_3; pfam08447
661410001368	putative active site [active]
661410001369	heme pocket [chemical binding]; other site
661410001370	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410001371	PAS fold; Region: PAS_3; pfam08447
661410001372	putative active site [active]
661410001373	heme pocket [chemical binding]; other site
661410001374	GAF domain; Region: GAF; pfam01590
661410001375	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410001376	PAS fold; Region: PAS_4; pfam08448
661410001377	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410001378	putative active site [active]
661410001379	heme pocket [chemical binding]; other site
661410001380	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410001381	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
661410001382	putative active site [active]
661410001383	heme pocket [chemical binding]; other site
661410001384	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410001385	dimer interface [polypeptide binding]; other site
661410001386	phosphorylation site [posttranslational modification]
661410001387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410001388	ATP binding site [chemical binding]; other site
661410001389	Mg2+ binding site [ion binding]; other site
661410001390	G-X-G motif; other site
661410001391	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410001392	Response regulator receiver domain; Region: Response_reg; pfam00072
661410001393	active site
661410001394	phosphorylation site [posttranslational modification]
661410001395	intermolecular recognition site; other site
661410001396	dimerization interface [polypeptide binding]; other site
661410001397	PAS domain; Region: PAS; smart00091
661410001398	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
661410001399	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
661410001400	dimer interface [polypeptide binding]; other site
661410001401	active site
661410001402	glutathione binding site [chemical binding]; other site
661410001403	aminopeptidase N; Provisional; Region: pepN; PRK14015
661410001404	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
661410001405	Zn binding site [ion binding]; other site
661410001406	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
661410001407	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410001408	PAS fold; Region: PAS_3; pfam08447
661410001409	putative active site [active]
661410001410	heme pocket [chemical binding]; other site
661410001411	PAS fold; Region: PAS_7; pfam12860
661410001412	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410001413	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410001414	dimer interface [polypeptide binding]; other site
661410001415	phosphorylation site [posttranslational modification]
661410001416	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410001417	ATP binding site [chemical binding]; other site
661410001418	Mg2+ binding site [ion binding]; other site
661410001419	G-X-G motif; other site
661410001420	Arginase family; Region: Arginase; cd09989
661410001421	active site
661410001422	Mn binding site [ion binding]; other site
661410001423	oligomer interface [polypeptide binding]; other site
661410001424	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
661410001425	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
661410001426	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
661410001427	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
661410001428	ATP-NAD kinase; Region: NAD_kinase; pfam01513
661410001429	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
661410001430	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
661410001431	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
661410001432	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
661410001433	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410001434	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
661410001435	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
661410001436	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
661410001437	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
661410001438	catalytic residue [active]
661410001439	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
661410001440	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
661410001441	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
661410001442	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
661410001443	homotetramer interface [polypeptide binding]; other site
661410001444	NAD(P) binding site [chemical binding]; other site
661410001445	homodimer interface [polypeptide binding]; other site
661410001446	active site
661410001447	acyl carrier protein; Provisional; Region: acpP; PRK00982
661410001448	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
661410001449	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
661410001450	dimer interface [polypeptide binding]; other site
661410001451	active site
661410001452	YceG-like family; Region: YceG; pfam02618
661410001453	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
661410001454	dimerization interface [polypeptide binding]; other site
661410001455	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
661410001456	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
661410001457	motif II; other site
661410001458	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
661410001459	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
661410001460	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
661410001461	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
661410001462	Acetokinase family; Region: Acetate_kinase; cl17229
661410001463	propionate/acetate kinase; Provisional; Region: PRK12379
661410001464	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410001465	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
661410001466	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410001467	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
661410001468	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
661410001469	Walker A/P-loop; other site
661410001470	ATP binding site [chemical binding]; other site
661410001471	Q-loop/lid; other site
661410001472	ABC transporter signature motif; other site
661410001473	Walker B; other site
661410001474	D-loop; other site
661410001475	H-loop/switch region; other site
661410001476	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410001477	Walker A/P-loop; other site
661410001478	ATP binding site [chemical binding]; other site
661410001479	Q-loop/lid; other site
661410001480	ABC transporter signature motif; other site
661410001481	Walker B; other site
661410001482	D-loop; other site
661410001483	H-loop/switch region; other site
661410001484	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
661410001485	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
661410001486	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
661410001487	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
661410001488	ABC-2 type transporter; Region: ABC2_membrane; cl17235
661410001489	putative phosphoketolase; Provisional; Region: PRK05261
661410001490	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
661410001491	TPP-binding site; other site
661410001492	XFP C-terminal domain; Region: XFP_C; pfam09363
661410001493	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
661410001494	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
661410001495	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
661410001496	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410001497	Walker A/P-loop; other site
661410001498	ATP binding site [chemical binding]; other site
661410001499	Q-loop/lid; other site
661410001500	ABC transporter signature motif; other site
661410001501	Walker B; other site
661410001502	D-loop; other site
661410001503	H-loop/switch region; other site
661410001504	TOBE domain; Region: TOBE_2; pfam08402
661410001505	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
661410001506	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
661410001507	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
661410001508	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410001509	ABC-ATPase subunit interface; other site
661410001510	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410001511	putative PBP binding loops; other site
661410001512	dimer interface [polypeptide binding]; other site
661410001513	ABC-ATPase subunit interface; other site
661410001514	CysZ-like protein; Reviewed; Region: PRK12768
661410001515	Kelch motif; Region: Kelch_1; pfam01344
661410001516	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
661410001517	Kelch domain; Region: Kelch; smart00612
661410001518	Galactose oxidase, central domain; Region: Kelch_3; cl02701
661410001519	Kelch domain; Region: Kelch; smart00612
661410001520	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
661410001521	Kelch domain; Region: Kelch; smart00612
661410001522	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
661410001523	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
661410001524	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
661410001525	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410001526	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410001527	ligand binding site [chemical binding]; other site
661410001528	flexible hinge region; other site
661410001529	Cupin domain; Region: Cupin_2; cl17218
661410001530	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
661410001531	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
661410001532	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
661410001533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410001534	dimer interface [polypeptide binding]; other site
661410001535	conserved gate region; other site
661410001536	putative PBP binding loops; other site
661410001537	ABC-ATPase subunit interface; other site
661410001538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410001539	dimer interface [polypeptide binding]; other site
661410001540	conserved gate region; other site
661410001541	putative PBP binding loops; other site
661410001542	ABC-ATPase subunit interface; other site
661410001543	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
661410001544	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
661410001545	Walker A/P-loop; other site
661410001546	ATP binding site [chemical binding]; other site
661410001547	Q-loop/lid; other site
661410001548	ABC transporter signature motif; other site
661410001549	Walker B; other site
661410001550	D-loop; other site
661410001551	H-loop/switch region; other site
661410001552	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
661410001553	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
661410001554	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
661410001555	minor groove reading motif; other site
661410001556	helix-hairpin-helix signature motif; other site
661410001557	substrate binding pocket [chemical binding]; other site
661410001558	active site
661410001559	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
661410001560	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
661410001561	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
661410001562	ATP binding site [chemical binding]; other site
661410001563	active site
661410001564	substrate binding site [chemical binding]; other site
661410001565	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
661410001566	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
661410001567	Probable Catalytic site; other site
661410001568	metal-binding site
661410001569	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
661410001570	active site
661410001571	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
661410001572	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
661410001573	Probable Catalytic site; other site
661410001574	metal-binding site
661410001575	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
661410001576	Protein of unknown function DUF45; Region: DUF45; pfam01863
661410001577	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
661410001578	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
661410001579	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410001580	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410001581	dimer interface [polypeptide binding]; other site
661410001582	phosphorylation site [posttranslational modification]
661410001583	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410001584	ATP binding site [chemical binding]; other site
661410001585	Mg2+ binding site [ion binding]; other site
661410001586	G-X-G motif; other site
661410001587	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
661410001588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410001589	active site
661410001590	phosphorylation site [posttranslational modification]
661410001591	intermolecular recognition site; other site
661410001592	dimerization interface [polypeptide binding]; other site
661410001593	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
661410001594	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
661410001595	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
661410001596	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
661410001597	putative active site [active]
661410001598	catalytic triad [active]
661410001599	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
661410001600	active site
661410001601	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
661410001602	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
661410001603	active site
661410001604	dimerization interface [polypeptide binding]; other site
661410001605	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
661410001606	active site
661410001607	pyrophosphate binding site [ion binding]; other site
661410001608	thiamine phosphate binding site [chemical binding]; other site
661410001609	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
661410001610	ThiS interaction site; other site
661410001611	putative active site [active]
661410001612	tetramer interface [polypeptide binding]; other site
661410001613	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
661410001614	thiS-thiF/thiG interaction site; other site
661410001615	hydroxyglutarate oxidase; Provisional; Region: PRK11728
661410001616	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
661410001617	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
661410001618	cyclase homology domain; Region: CHD; cd07302
661410001619	nucleotidyl binding site; other site
661410001620	metal binding site [ion binding]; metal-binding site
661410001621	dimer interface [polypeptide binding]; other site
661410001622	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
661410001623	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
661410001624	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
661410001625	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
661410001626	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
661410001627	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
661410001628	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
661410001629	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
661410001630	DNA binding residues [nucleotide binding]
661410001631	DNA primase, catalytic core; Region: dnaG; TIGR01391
661410001632	CHC2 zinc finger; Region: zf-CHC2; pfam01807
661410001633	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
661410001634	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
661410001635	active site
661410001636	metal binding site [ion binding]; metal-binding site
661410001637	interdomain interaction site; other site
661410001638	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
661410001639	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
661410001640	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
661410001641	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
661410001642	Yqey-like protein; Region: YqeY; pfam09424
661410001643	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
661410001644	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
661410001645	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
661410001646	catalytic site [active]
661410001647	subunit interface [polypeptide binding]; other site
661410001648	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
661410001649	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
661410001650	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
661410001651	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
661410001652	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
661410001653	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
661410001654	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12692
661410001655	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
661410001656	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
661410001657	Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261
661410001658	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
661410001659	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
661410001660	flagellar basal body P-ring protein; Reviewed; Region: flgI; PRK12789
661410001661	Flagellar P-ring protein; Region: FlgI; pfam02119
661410001662	Uncharacterized conserved protein [Function unknown]; Region: COG3334
661410001663	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
661410001664	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788
661410001665	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
661410001666	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK12783
661410001667	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
661410001668	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
661410001669	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
661410001670	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
661410001671	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
661410001672	ligand binding site [chemical binding]; other site
661410001673	chemotaxis protein; Reviewed; Region: PRK12798
661410001674	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
661410001675	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
661410001676	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
661410001677	N-acetyl-D-glucosamine binding site [chemical binding]; other site
661410001678	proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787
661410001679	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410001680	active site
661410001681	dimerization interface [polypeptide binding]; other site
661410001682	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410001683	DNA binding site [nucleotide binding]
661410001684	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK13109
661410001685	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
661410001686	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
661410001687	FliG C-terminal domain; Region: FliG_C; pfam01706
661410001688	flagellar motor switch protein FliN; Region: fliN; TIGR02480
661410001689	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
661410001690	Flagellar motor switch protein FliM; Region: FliM; pfam02154
661410001691	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
661410001692	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
661410001693	flagellar motor protein MotA; Validated; Region: PRK09110
661410001694	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
661410001695	active site
661410001696	HslU subunit interaction site [polypeptide binding]; other site
661410001697	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
661410001698	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410001699	Walker A motif; other site
661410001700	ATP binding site [chemical binding]; other site
661410001701	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
661410001702	Walker B motif; other site
661410001703	arginine finger; other site
661410001704	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
661410001705	threonine and homoserine efflux system; Provisional; Region: PRK10532
661410001706	EamA-like transporter family; Region: EamA; pfam00892
661410001707	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
661410001708	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
661410001709	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
661410001710	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
661410001711	[2Fe-2S] cluster binding site [ion binding]; other site
661410001712	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
661410001713	hydrophobic ligand binding site; other site
661410001714	signal recognition particle protein; Provisional; Region: PRK10867
661410001715	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
661410001716	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
661410001717	P loop; other site
661410001718	GTP binding site [chemical binding]; other site
661410001719	Signal peptide binding domain; Region: SRP_SPB; pfam02978
661410001720	chorismate mutase; Provisional; Region: PRK09239
661410001721	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
661410001722	RimM N-terminal domain; Region: RimM; pfam01782
661410001723	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
661410001724	PRC-barrel domain; Region: PRC; pfam05239
661410001725	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
661410001726	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410001727	S-adenosylmethionine binding site [chemical binding]; other site
661410001728	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
661410001729	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
661410001730	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
661410001731	catalytic residue [active]
661410001732	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
661410001733	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
661410001734	ligand binding site [chemical binding]; other site
661410001735	NAD binding site [chemical binding]; other site
661410001736	dimerization interface [polypeptide binding]; other site
661410001737	catalytic site [active]
661410001738	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
661410001739	putative L-serine binding site [chemical binding]; other site
661410001740	Domain of unknown function (DUF1902); Region: DUF1902; pfam08972
661410001741	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
661410001742	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
661410001743	Protein of unknown function (DUF3140); Region: DUF3140; pfam11338
661410001744	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
661410001745	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
661410001746	cation binding site [ion binding]; other site
661410001747	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
661410001748	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
661410001749	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
661410001750	Walker A/P-loop; other site
661410001751	ATP binding site [chemical binding]; other site
661410001752	Q-loop/lid; other site
661410001753	ABC transporter signature motif; other site
661410001754	Walker B; other site
661410001755	D-loop; other site
661410001756	H-loop/switch region; other site
661410001757	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
661410001758	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
661410001759	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410001760	dimer interface [polypeptide binding]; other site
661410001761	putative CheW interface [polypeptide binding]; other site
661410001762	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
661410001763	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
661410001764	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
661410001765	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
661410001766	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
661410001767	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
661410001768	N-terminal plug; other site
661410001769	ligand-binding site [chemical binding]; other site
661410001770	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
661410001771	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
661410001772	AAA domain; Region: AAA_30; pfam13604
661410001773	Family description; Region: UvrD_C_2; pfam13538
661410001774	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
661410001775	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
661410001776	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410001777	homodimer interface [polypeptide binding]; other site
661410001778	catalytic residue [active]
661410001779	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
661410001780	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410001781	DNA binding site [nucleotide binding]
661410001782	flagellin; Reviewed; Region: PRK12687
661410001783	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
661410001784	PilZ domain; Region: PilZ; pfam07238
661410001785	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
661410001786	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
661410001787	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
661410001788	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
661410001789	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
661410001790	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
661410001791	Walker A motif; other site
661410001792	ATP binding site [chemical binding]; other site
661410001793	Walker B motif; other site
661410001794	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
661410001795	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
661410001796	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
661410001797	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
661410001798	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
661410001799	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
661410001800	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
661410001801	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
661410001802	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
661410001803	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
661410001804	Flagellar protein FlaF; Region: FlaF; pfam07309
661410001805	flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794
661410001806	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
661410001807	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
661410001808	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK12781
661410001809	flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792
661410001810	FHIPEP family; Region: FHIPEP; pfam00771
661410001811	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK12780
661410001812	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
661410001813	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
661410001814	inhibitor site; inhibition site
661410001815	active site
661410001816	dimer interface [polypeptide binding]; other site
661410001817	catalytic residue [active]
661410001818	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
661410001819	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
661410001820	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
661410001821	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410001822	putative active site [active]
661410001823	heme pocket [chemical binding]; other site
661410001824	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410001825	dimer interface [polypeptide binding]; other site
661410001826	phosphorylation site [posttranslational modification]
661410001827	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410001828	ATP binding site [chemical binding]; other site
661410001829	Mg2+ binding site [ion binding]; other site
661410001830	G-X-G motif; other site
661410001831	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
661410001832	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
661410001833	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410001834	Predicted transcriptional regulators [Transcription]; Region: COG1733
661410001835	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
661410001836	Transglycosylase; Region: Transgly; pfam00912
661410001837	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
661410001838	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
661410001839	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410001840	dimer interface [polypeptide binding]; other site
661410001841	putative CheW interface [polypeptide binding]; other site
661410001842	AMP nucleosidase; Provisional; Region: PRK08292
661410001843	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
661410001844	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
661410001845	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
661410001846	homodimer interaction site [polypeptide binding]; other site
661410001847	cofactor binding site; other site
661410001848	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
661410001849	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
661410001850	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
661410001851	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
661410001852	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
661410001853	putative active site [active]
661410001854	Zn binding site [ion binding]; other site
661410001855	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
661410001856	ligand binding site; other site
661410001857	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
661410001858	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
661410001859	ethanolamine permease; Region: 2A0305; TIGR00908
661410001860	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
661410001861	Fatty acid desaturase; Region: FA_desaturase; pfam00487
661410001862	Di-iron ligands [ion binding]; other site
661410001863	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
661410001864	dimerization interface [polypeptide binding]; other site
661410001865	putative DNA binding site [nucleotide binding]; other site
661410001866	putative Zn2+ binding site [ion binding]; other site
661410001867	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
661410001868	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
661410001869	catalytic triad [active]
661410001870	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
661410001871	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
661410001872	active site
661410001873	catalytic tetrad [active]
661410001874	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
661410001875	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
661410001876	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
661410001877	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
661410001878	active site
661410001879	DNA binding site [nucleotide binding]
661410001880	Int/Topo IB signature motif; other site
661410001881	HTH-like domain; Region: HTH_21; pfam13276
661410001882	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
661410001883	Integrase core domain; Region: rve; pfam00665
661410001884	Integrase core domain; Region: rve_3; pfam13683
661410001885	Transposase; Region: HTH_Tnp_1; pfam01527
661410001886	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
661410001887	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
661410001888	dimerization interface [polypeptide binding]; other site
661410001889	putative DNA binding site [nucleotide binding]; other site
661410001890	putative Zn2+ binding site [ion binding]; other site
661410001891	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
661410001892	Predicted transporter component [General function prediction only]; Region: COG2391
661410001893	Sulphur transport; Region: Sulf_transp; pfam04143
661410001894	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
661410001895	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
661410001896	active site residue [active]
661410001897	sensor protein QseC; Provisional; Region: PRK10337
661410001898	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410001899	dimer interface [polypeptide binding]; other site
661410001900	phosphorylation site [posttranslational modification]
661410001901	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410001902	ATP binding site [chemical binding]; other site
661410001903	Mg2+ binding site [ion binding]; other site
661410001904	G-X-G motif; other site
661410001905	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
661410001906	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410001907	active site
661410001908	phosphorylation site [posttranslational modification]
661410001909	intermolecular recognition site; other site
661410001910	dimerization interface [polypeptide binding]; other site
661410001911	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410001912	DNA binding site [nucleotide binding]
661410001913	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
661410001914	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
661410001915	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
661410001916	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
661410001917	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
661410001918	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
661410001919	catalytic residues [active]
661410001920	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
661410001921	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410001922	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
661410001923	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410001924	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410001925	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410001926	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
661410001927	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
661410001928	DsrE/DsrF-like family; Region: DrsE; pfam02635
661410001929	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
661410001930	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
661410001931	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
661410001932	catalytic residues [active]
661410001933	Staphylococcal nuclease homologues; Region: SNc; smart00318
661410001934	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
661410001935	Catalytic site; other site
661410001936	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
661410001937	Winged helix-turn helix; Region: HTH_29; pfam13551
661410001938	Helix-turn-helix domain; Region: HTH_28; pfam13518
661410001939	Integrase core domain; Region: rve; pfam00665
661410001940	Integrase core domain; Region: rve_3; pfam13683
661410001941	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
661410001942	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
661410001943	DsrE/DsrF-like family; Region: DrsE; cl00672
661410001944	DsrE/DsrF-like family; Region: DrsE; pfam02635
661410001945	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
661410001946	Cytochrome c; Region: Cytochrom_C; pfam00034
661410001947	bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113
661410001948	Moco binding site; other site
661410001949	metal coordination site [ion binding]; other site
661410001950	dimerization interface [polypeptide binding]; other site
661410001951	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
661410001952	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
661410001953	active site
661410001954	metal binding site [ion binding]; metal-binding site
661410001955	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
661410001956	Cytochrome c [Energy production and conversion]; Region: COG3258
661410001957	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
661410001958	sulfur oxidation protein SoxY; Provisional; Region: PRK07474
661410001959	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
661410001960	Cytochrome c; Region: Cytochrom_C; pfam00034
661410001961	SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951
661410001962	catalytic residues [active]
661410001963	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
661410001964	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
661410001965	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
661410001966	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
661410001967	dimerization interface [polypeptide binding]; other site
661410001968	putative DNA binding site [nucleotide binding]; other site
661410001969	putative Zn2+ binding site [ion binding]; other site
661410001970	Domain of unknown function (DUF336); Region: DUF336; cl01249
661410001971	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
661410001972	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
661410001973	Sulfate transporter family; Region: Sulfate_transp; pfam00916
661410001974	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
661410001975	CoA binding domain; Region: CoA_binding; smart00881
661410001976	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
661410001977	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
661410001978	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
661410001979	CoA-ligase; Region: Ligase_CoA; pfam00549
661410001980	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
661410001981	putative catalytic cysteine [active]
661410001982	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410001983	D-galactonate transporter; Region: 2A0114; TIGR00893
661410001984	putative substrate translocation pore; other site
661410001985	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410001986	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410001987	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
661410001988	dimerization interface [polypeptide binding]; other site
661410001989	choline dehydrogenase; Validated; Region: PRK02106
661410001990	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
661410001991	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
661410001992	metabolite-proton symporter; Region: 2A0106; TIGR00883
661410001993	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410001994	putative substrate translocation pore; other site
661410001995	Predicted membrane protein [Function unknown]; Region: COG2855
661410001996	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
661410001997	sulfite oxidase; Provisional; Region: PLN00177
661410001998	Moco binding site; other site
661410001999	metal coordination site [ion binding]; other site
661410002000	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
661410002001	Moco binding site; other site
661410002002	metal coordination site [ion binding]; other site
661410002003	Cytochrome c; Region: Cytochrom_C; pfam00034
661410002004	sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
661410002005	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
661410002006	PYR/PP interface [polypeptide binding]; other site
661410002007	dimer interface [polypeptide binding]; other site
661410002008	TPP binding site [chemical binding]; other site
661410002009	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
661410002010	Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013
661410002011	TPP-binding site; other site
661410002012	Transcriptional regulator [Transcription]; Region: IclR; COG1414
661410002013	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
661410002014	Bacterial transcriptional regulator; Region: IclR; pfam01614
661410002015	propionate/acetate kinase; Provisional; Region: PRK12379
661410002016	Acetokinase family; Region: Acetate_kinase; cl17229
661410002017	VCBS repeat; Region: VCBS_repeat; TIGR01965
661410002018	VCBS repeat; Region: VCBS_repeat; TIGR01965
661410002019	VCBS repeat; Region: VCBS_repeat; TIGR01965
661410002020	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410002021	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
661410002022	salt bridge; other site
661410002023	non-specific DNA binding site [nucleotide binding]; other site
661410002024	sequence-specific DNA binding site [nucleotide binding]; other site
661410002025	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
661410002026	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410002027	non-specific DNA binding site [nucleotide binding]; other site
661410002028	salt bridge; other site
661410002029	sequence-specific DNA binding site [nucleotide binding]; other site
661410002030	Integrase core domain; Region: rve_3; pfam13683
661410002031	DDE superfamily endonuclease; Region: DDE_3; pfam13358
661410002032	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
661410002033	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
661410002034	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
661410002035	putative active site [active]
661410002036	putative metal binding residues [ion binding]; other site
661410002037	signature motif; other site
661410002038	putative dimer interface [polypeptide binding]; other site
661410002039	putative phosphate binding site [ion binding]; other site
661410002040	hypothetical protein; Provisional; Region: PRK07236
661410002041	hypothetical protein; Provisional; Region: PRK07588
661410002042	Predicted membrane protein [Function unknown]; Region: COG1238
661410002043	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
661410002044	Putative ParB-like nuclease; Region: ParBc_2; cl17538
661410002045	Acyltransferase family; Region: Acyl_transf_3; pfam01757
661410002046	EVE domain; Region: EVE; pfam01878
661410002047	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
661410002048	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
661410002049	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
661410002050	PAS domain; Region: PAS_9; pfam13426
661410002051	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410002052	putative active site [active]
661410002053	heme pocket [chemical binding]; other site
661410002054	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410002055	PAS domain; Region: PAS_9; pfam13426
661410002056	putative active site [active]
661410002057	heme pocket [chemical binding]; other site
661410002058	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410002059	dimer interface [polypeptide binding]; other site
661410002060	putative CheW interface [polypeptide binding]; other site
661410002061	UGMP family protein; Validated; Region: PRK09604
661410002062	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
661410002063	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
661410002064	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
661410002065	active site
661410002066	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
661410002067	HemY protein N-terminus; Region: HemY_N; pfam07219
661410002068	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
661410002069	active site
661410002070	Int/Topo IB signature motif; other site
661410002071	catalytic residues [active]
661410002072	DNA binding site [nucleotide binding]
661410002073	transcriptional regulator; Provisional; Region: PRK10632
661410002074	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410002075	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
661410002076	putative effector binding pocket; other site
661410002077	putative dimerization interface [polypeptide binding]; other site
661410002078	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
661410002079	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
661410002080	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
661410002081	Enoylreductase; Region: PKS_ER; smart00829
661410002082	putative NAD(P) binding site [chemical binding]; other site
661410002083	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
661410002084	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
661410002085	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
661410002086	Virulence-associated protein E; Region: VirE; pfam05272
661410002087	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
661410002088	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
661410002089	catalytic residues [active]
661410002090	catalytic nucleophile [active]
661410002091	Presynaptic Site I dimer interface [polypeptide binding]; other site
661410002092	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
661410002093	Synaptic Flat tetramer interface [polypeptide binding]; other site
661410002094	Synaptic Site I dimer interface [polypeptide binding]; other site
661410002095	DNA binding site [nucleotide binding]
661410002096	GAF domain; Region: GAF_2; pfam13185
661410002097	GAF domain; Region: GAF; pfam01590
661410002098	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410002099	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
661410002100	putative active site [active]
661410002101	heme pocket [chemical binding]; other site
661410002102	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410002103	PAS fold; Region: PAS_3; pfam08447
661410002104	putative active site [active]
661410002105	heme pocket [chemical binding]; other site
661410002106	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410002107	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410002108	metal binding site [ion binding]; metal-binding site
661410002109	active site
661410002110	I-site; other site
661410002111	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410002112	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
661410002113	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
661410002114	catalytic residues [active]
661410002115	catalytic nucleophile [active]
661410002116	Presynaptic Site I dimer interface [polypeptide binding]; other site
661410002117	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
661410002118	Synaptic Flat tetramer interface [polypeptide binding]; other site
661410002119	Synaptic Site I dimer interface [polypeptide binding]; other site
661410002120	DNA binding site [nucleotide binding]
661410002121	Virulence-associated protein E; Region: VirE; pfam05272
661410002122	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
661410002123	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
661410002124	catalytic residues [active]
661410002125	catalytic nucleophile [active]
661410002126	Presynaptic Site I dimer interface [polypeptide binding]; other site
661410002127	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
661410002128	Synaptic Flat tetramer interface [polypeptide binding]; other site
661410002129	Synaptic Site I dimer interface [polypeptide binding]; other site
661410002130	DNA binding site [nucleotide binding]
661410002131	Recombinase; Region: Recombinase; pfam07508
661410002132	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
661410002133	Transposase; Region: DEDD_Tnp_IS110; pfam01548
661410002134	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
661410002135	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
661410002136	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
661410002137	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410002138	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
661410002139	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410002140	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410002141	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
661410002142	putative switch regulator; other site
661410002143	non-specific DNA interactions [nucleotide binding]; other site
661410002144	DNA binding site [nucleotide binding]
661410002145	sequence specific DNA binding site [nucleotide binding]; other site
661410002146	putative cAMP binding site [chemical binding]; other site
661410002147	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
661410002148	active site
661410002149	phosphorylation site [posttranslational modification]
661410002150	intermolecular recognition site; other site
661410002151	dimerization interface [polypeptide binding]; other site
661410002152	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
661410002153	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
661410002154	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
661410002155	Cytochrome P450; Region: p450; pfam00067
661410002156	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
661410002157	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
661410002158	response regulator; Provisional; Region: PRK13435
661410002159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
661410002160	active site
661410002161	intermolecular recognition site; other site
661410002162	dimerization interface [polypeptide binding]; other site
661410002163	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410002164	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410002165	ligand binding site [chemical binding]; other site
661410002166	flexible hinge region; other site
661410002167	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
661410002168	putative switch regulator; other site
661410002169	non-specific DNA interactions [nucleotide binding]; other site
661410002170	DNA binding site [nucleotide binding]
661410002171	sequence specific DNA binding site [nucleotide binding]; other site
661410002172	putative cAMP binding site [chemical binding]; other site
661410002173	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410002174	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
661410002175	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
661410002176	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410002177	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410002178	ligand binding site [chemical binding]; other site
661410002179	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
661410002180	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410002181	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410002182	ligand binding site [chemical binding]; other site
661410002183	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
661410002184	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
661410002185	active site
661410002186	catalytic residues [active]
661410002187	DNA binding site [nucleotide binding]
661410002188	Int/Topo IB signature motif; other site
661410002189	Uncharacterized conserved protein [Function unknown]; Region: COG1262
661410002190	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
661410002191	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
661410002192	Sulfatase; Region: Sulfatase; cl17466
661410002193	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
661410002194	Sulfatase; Region: Sulfatase; cl17466
661410002195	Integrase core domain; Region: rve_3; cl15866
661410002196	PAS domain; Region: PAS_9; pfam13426
661410002197	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
661410002198	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410002199	putative active site [active]
661410002200	heme pocket [chemical binding]; other site
661410002201	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410002202	HWE histidine kinase; Region: HWE_HK; smart00911
661410002203	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
661410002204	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
661410002205	putative NAD(P) binding site [chemical binding]; other site
661410002206	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410002207	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410002208	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
661410002209	putative effector binding pocket; other site
661410002210	putative dimerization interface [polypeptide binding]; other site
661410002211	PAS fold; Region: PAS_4; pfam08448
661410002212	PAS fold; Region: PAS_4; pfam08448
661410002213	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410002214	putative active site [active]
661410002215	heme pocket [chemical binding]; other site
661410002216	PAS fold; Region: PAS_3; pfam08447
661410002217	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410002218	PAS fold; Region: PAS_3; pfam08447
661410002219	putative active site [active]
661410002220	heme pocket [chemical binding]; other site
661410002221	PAS domain S-box; Region: sensory_box; TIGR00229
661410002222	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410002223	putative active site [active]
661410002224	heme pocket [chemical binding]; other site
661410002225	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410002226	dimer interface [polypeptide binding]; other site
661410002227	phosphorylation site [posttranslational modification]
661410002228	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410002229	ATP binding site [chemical binding]; other site
661410002230	Mg2+ binding site [ion binding]; other site
661410002231	G-X-G motif; other site
661410002232	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410002233	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410002234	active site
661410002235	phosphorylation site [posttranslational modification]
661410002236	intermolecular recognition site; other site
661410002237	dimerization interface [polypeptide binding]; other site
661410002238	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
661410002239	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
661410002240	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
661410002241	Winged helix-turn helix; Region: HTH_29; pfam13551
661410002242	Integrase core domain; Region: rve; pfam00665
661410002243	Integrase core domain; Region: rve_3; pfam13683
661410002244	B12 binding domain; Region: B12-binding; pfam02310
661410002245	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
661410002246	Terminase-like family; Region: Terminase_6; pfam03237
661410002247	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
661410002248	ParB-like nuclease domain; Region: ParBc; pfam02195
661410002249	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
661410002250	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
661410002251	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410002252	S-adenosylmethionine binding site [chemical binding]; other site
661410002253	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410002254	dimer interface [polypeptide binding]; other site
661410002255	putative CheW interface [polypeptide binding]; other site
661410002256	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
661410002257	DEAD/DEAH box helicase; Region: DEAD; pfam00270
661410002258	ATP binding site [chemical binding]; other site
661410002259	putative Mg++ binding site [ion binding]; other site
661410002260	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
661410002261	nucleotide binding region [chemical binding]; other site
661410002262	ATP-binding site [chemical binding]; other site
661410002263	Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513
661410002264	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
661410002265	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
661410002266	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
661410002267	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
661410002268	RNA binding site [nucleotide binding]; other site
661410002269	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
661410002270	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
661410002271	Walker A/P-loop; other site
661410002272	ATP binding site [chemical binding]; other site
661410002273	Q-loop/lid; other site
661410002274	ABC transporter signature motif; other site
661410002275	Walker B; other site
661410002276	D-loop; other site
661410002277	H-loop/switch region; other site
661410002278	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
661410002279	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
661410002280	FHIPEP family; Region: FHIPEP; pfam00771
661410002281	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
661410002282	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
661410002283	dimerization interface [polypeptide binding]; other site
661410002284	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410002285	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
661410002286	dimer interface [polypeptide binding]; other site
661410002287	putative CheW interface [polypeptide binding]; other site
661410002288	Predicted integral membrane protein [Function unknown]; Region: COG0392
661410002289	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
661410002290	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927
661410002291	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
661410002292	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
661410002293	Walker A motif/ATP binding site; other site
661410002294	Walker B motif; other site
661410002295	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
661410002296	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410002297	active site
661410002298	phosphorylation site [posttranslational modification]
661410002299	intermolecular recognition site; other site
661410002300	dimerization interface [polypeptide binding]; other site
661410002301	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410002302	DNA binding site [nucleotide binding]
661410002303	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
661410002304	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
661410002305	trimer interface [polypeptide binding]; other site
661410002306	active site
661410002307	substrate binding site [chemical binding]; other site
661410002308	CoA binding site [chemical binding]; other site
661410002309	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
661410002310	Malic enzyme, N-terminal domain; Region: malic; pfam00390
661410002311	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
661410002312	putative NAD(P) binding site [chemical binding]; other site
661410002313	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
661410002314	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
661410002315	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
661410002316	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
661410002317	Probable Catalytic site; other site
661410002318	metal-binding site
661410002319	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410002320	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
661410002321	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410002322	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
661410002323	hypothetical protein; Validated; Region: PRK09104
661410002324	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
661410002325	metal binding site [ion binding]; metal-binding site
661410002326	putative dimer interface [polypeptide binding]; other site
661410002327	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
661410002328	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
661410002329	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
661410002330	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
661410002331	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
661410002332	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
661410002333	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
661410002334	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
661410002335	camphor resistance protein CrcB; Provisional; Region: PRK14198
661410002336	Predicted membrane protein [Function unknown]; Region: COG2510
661410002337	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
661410002338	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
661410002339	MarR family; Region: MarR_2; pfam12802
661410002340	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
661410002341	active site
661410002342	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
661410002343	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
661410002344	Probable Catalytic site; other site
661410002345	metal-binding site
661410002346	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
661410002347	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
661410002348	substrate binding site; other site
661410002349	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
661410002350	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
661410002351	NAD binding site [chemical binding]; other site
661410002352	homotetramer interface [polypeptide binding]; other site
661410002353	homodimer interface [polypeptide binding]; other site
661410002354	substrate binding site [chemical binding]; other site
661410002355	active site
661410002356	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
661410002357	Methyltransferase domain; Region: Methyltransf_23; pfam13489
661410002358	Methyltransferase domain; Region: Methyltransf_12; pfam08242
661410002359	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
661410002360	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
661410002361	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
661410002362	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410002363	NAD(P) binding site [chemical binding]; other site
661410002364	active site
661410002365	Response regulator receiver domain; Region: Response_reg; pfam00072
661410002366	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410002367	active site
661410002368	phosphorylation site [posttranslational modification]
661410002369	intermolecular recognition site; other site
661410002370	dimerization interface [polypeptide binding]; other site
661410002371	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
661410002372	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
661410002373	inhibitor-cofactor binding pocket; inhibition site
661410002374	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410002375	catalytic residue [active]
661410002376	glycine dehydrogenase; Provisional; Region: PRK05367
661410002377	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
661410002378	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
661410002379	catalytic residue [active]
661410002380	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
661410002381	tetramer interface [polypeptide binding]; other site
661410002382	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410002383	catalytic residue [active]
661410002384	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
661410002385	lipoyl attachment site [posttranslational modification]; other site
661410002386	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
661410002387	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
661410002388	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
661410002389	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
661410002390	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
661410002391	catalytic residue [active]
661410002392	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
661410002393	NlpC/P60 family; Region: NLPC_P60; pfam00877
661410002394	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410002395	C factor cell-cell signaling protein; Provisional; Region: PRK09009
661410002396	NAD(P) binding site [chemical binding]; other site
661410002397	active site
661410002398	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
661410002399	MgtC family; Region: MgtC; pfam02308
661410002400	MoxR-like ATPases [General function prediction only]; Region: COG0714
661410002401	ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726
661410002402	Protein of unknown function DUF58; Region: DUF58; pfam01882
661410002403	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
661410002404	metal ion-dependent adhesion site (MIDAS); other site
661410002405	von Willebrand factor type A domain; Region: VWA_2; pfam13519
661410002406	metal ion-dependent adhesion site (MIDAS); other site
661410002407	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
661410002408	Tetratricopeptide repeat; Region: TPR_16; pfam13432
661410002409	TPR motif; other site
661410002410	binding surface
661410002411	Oxygen tolerance; Region: BatD; pfam13584
661410002412	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
661410002413	putative heme binding pocket [chemical binding]; other site
661410002414	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
661410002415	EamA-like transporter family; Region: EamA; pfam00892
661410002416	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
661410002417	putative active site; other site
661410002418	putative triphosphate binding site [ion binding]; other site
661410002419	methionine sulfoxide reductase B; Provisional; Region: PRK00222
661410002420	SelR domain; Region: SelR; pfam01641
661410002421	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
661410002422	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410002423	PAS domain; Region: PAS_9; pfam13426
661410002424	putative active site [active]
661410002425	heme pocket [chemical binding]; other site
661410002426	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410002427	PAS domain; Region: PAS_9; pfam13426
661410002428	putative active site [active]
661410002429	heme pocket [chemical binding]; other site
661410002430	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410002431	HWE histidine kinase; Region: HWE_HK; pfam07536
661410002432	malonyl-CoA synthase; Validated; Region: PRK07514
661410002433	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
661410002434	acyl-activating enzyme (AAE) consensus motif; other site
661410002435	active site
661410002436	AMP binding site [chemical binding]; other site
661410002437	CoA binding site [chemical binding]; other site
661410002438	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
661410002439	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
661410002440	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
661410002441	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
661410002442	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
661410002443	intracellular protease, PfpI family; Region: PfpI; TIGR01382
661410002444	proposed catalytic triad [active]
661410002445	conserved cys residue [active]
661410002446	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
661410002447	DNA-binding site [nucleotide binding]; DNA binding site
661410002448	RNA-binding motif; other site
661410002449	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
661410002450	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
661410002451	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
661410002452	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
661410002453	Permease; Region: Permease; pfam02405
661410002454	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
661410002455	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
661410002456	Walker A/P-loop; other site
661410002457	ATP binding site [chemical binding]; other site
661410002458	Q-loop/lid; other site
661410002459	ABC transporter signature motif; other site
661410002460	Walker B; other site
661410002461	D-loop; other site
661410002462	H-loop/switch region; other site
661410002463	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
661410002464	mce related protein; Region: MCE; pfam02470
661410002465	Protein of unknown function (DUF330); Region: DUF330; cl01135
661410002466	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
661410002467	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
661410002468	active site
661410002469	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
661410002470	Ribosome modulation factor; Region: RMF; cl01207
661410002471	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
661410002472	UbiA prenyltransferase family; Region: UbiA; pfam01040
661410002473	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
661410002474	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
661410002475	active site
661410002476	homotetramer interface [polypeptide binding]; other site
661410002477	homodimer interface [polypeptide binding]; other site
661410002478	glutamate--cysteine ligase; Region: PLN02611
661410002479	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
661410002480	CPxP  motif; other site
661410002481	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
661410002482	dimer interface [polypeptide binding]; other site
661410002483	ADP-ribose binding site [chemical binding]; other site
661410002484	active site
661410002485	nudix motif; other site
661410002486	metal binding site [ion binding]; metal-binding site
661410002487	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
661410002488	PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417
661410002489	primary metal binding site; other site
661410002490	catalytic residues [active]
661410002491	Predicted aspartyl protease [General function prediction only]; Region: COG3577
661410002492	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
661410002493	catalytic motif [active]
661410002494	Catalytic residue [active]
661410002495	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
661410002496	cobalamin synthase; Reviewed; Region: cobS; PRK00235
661410002497	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
661410002498	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
661410002499	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
661410002500	putative dimer interface [polypeptide binding]; other site
661410002501	active site pocket [active]
661410002502	putative cataytic base [active]
661410002503	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410002504	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410002505	dimer interface [polypeptide binding]; other site
661410002506	phosphorylation site [posttranslational modification]
661410002507	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410002508	ATP binding site [chemical binding]; other site
661410002509	Mg2+ binding site [ion binding]; other site
661410002510	G-X-G motif; other site
661410002511	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
661410002512	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
661410002513	catalytic loop [active]
661410002514	iron binding site [ion binding]; other site
661410002515	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
661410002516	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
661410002517	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
661410002518	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
661410002519	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
661410002520	PAS domain S-box; Region: sensory_box; TIGR00229
661410002521	PAS domain; Region: PAS; smart00091
661410002522	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410002523	GAF domain; Region: GAF; pfam01590
661410002524	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410002525	GAF domain; Region: GAF; cl17456
661410002526	PAS domain; Region: PAS_9; pfam13426
661410002527	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410002528	putative active site [active]
661410002529	heme pocket [chemical binding]; other site
661410002530	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410002531	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
661410002532	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410002533	PAS fold; Region: PAS_3; pfam08447
661410002534	putative active site [active]
661410002535	heme pocket [chemical binding]; other site
661410002536	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410002537	HWE histidine kinase; Region: HWE_HK; smart00911
661410002538	indole acetimide hydrolase; Validated; Region: PRK07488
661410002539	Amidase; Region: Amidase; cl11426
661410002540	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
661410002541	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
661410002542	B1 nucleotide binding pocket [chemical binding]; other site
661410002543	B2 nucleotide binding pocket [chemical binding]; other site
661410002544	CAS motifs; other site
661410002545	active site
661410002546	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
661410002547	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
661410002548	FAD binding domain; Region: FAD_binding_4; pfam01565
661410002549	Cytochrome c; Region: Cytochrom_C; cl11414
661410002550	Transcriptional regulators [Transcription]; Region: MarR; COG1846
661410002551	MarR family; Region: MarR; pfam01047
661410002552	Predicted integral membrane protein [Function unknown]; Region: COG5436
661410002553	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
661410002554	Transglycosylase; Region: Transgly; pfam00912
661410002555	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
661410002556	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
661410002557	hypothetical protein; Provisional; Region: PRK05170
661410002558	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
661410002559	TadE-like protein; Region: TadE; pfam07811
661410002560	Predicted ATPase [General function prediction only]; Region: COG1485
661410002561	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410002562	Walker B; other site
661410002563	D-loop; other site
661410002564	H-loop/switch region; other site
661410002565	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
661410002566	active site
661410002567	DNA binding site [nucleotide binding]
661410002568	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
661410002569	RNA/DNA hybrid binding site [nucleotide binding]; other site
661410002570	active site
661410002571	glutathione synthetase; Provisional; Region: PRK05246
661410002572	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
661410002573	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
661410002574	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
661410002575	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
661410002576	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
661410002577	amidase catalytic site [active]
661410002578	Zn binding residues [ion binding]; other site
661410002579	substrate binding site [chemical binding]; other site
661410002580	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
661410002581	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
661410002582	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
661410002583	putative metal binding site [ion binding]; other site
661410002584	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
661410002585	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
661410002586	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
661410002587	FMN binding site [chemical binding]; other site
661410002588	active site
661410002589	catalytic residues [active]
661410002590	substrate binding site [chemical binding]; other site
661410002591	PAS fold; Region: PAS_7; pfam12860
661410002592	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410002593	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410002594	metal binding site [ion binding]; metal-binding site
661410002595	active site
661410002596	I-site; other site
661410002597	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410002598	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
661410002599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410002600	active site
661410002601	phosphorylation site [posttranslational modification]
661410002602	intermolecular recognition site; other site
661410002603	dimerization interface [polypeptide binding]; other site
661410002604	Sensors of blue-light using FAD; Region: BLUF; pfam04940
661410002605	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
661410002606	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
661410002607	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
661410002608	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
661410002609	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
661410002610	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
661410002611	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
661410002612	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
661410002613	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
661410002614	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
661410002615	peptide chain release factor 1; Validated; Region: prfA; PRK00591
661410002616	This domain is found in peptide chain release factors; Region: PCRF; smart00937
661410002617	RF-1 domain; Region: RF-1; pfam00472
661410002618	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026
661410002619	GAF domain; Region: GAF; pfam01590
661410002620	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
661410002621	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
661410002622	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
661410002623	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
661410002624	aspartate kinase; Reviewed; Region: PRK06635
661410002625	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
661410002626	putative nucleotide binding site [chemical binding]; other site
661410002627	putative catalytic residues [active]
661410002628	putative Mg ion binding site [ion binding]; other site
661410002629	putative aspartate binding site [chemical binding]; other site
661410002630	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
661410002631	putative allosteric regulatory site; other site
661410002632	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
661410002633	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
661410002634	Methyltransferase domain; Region: Methyltransf_11; pfam08241
661410002635	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
661410002636	substrate binding site [chemical binding]; other site
661410002637	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
661410002638	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
661410002639	NAD(P) binding site [chemical binding]; other site
661410002640	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
661410002641	active site
661410002642	putative DNA-binding cleft [nucleotide binding]; other site
661410002643	dimer interface [polypeptide binding]; other site
661410002644	Uncharacterized conserved protein [Function unknown]; Region: COG2353
661410002645	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
661410002646	RuvA N terminal domain; Region: RuvA_N; pfam01330
661410002647	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
661410002648	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410002649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410002650	active site
661410002651	phosphorylation site [posttranslational modification]
661410002652	intermolecular recognition site; other site
661410002653	dimerization interface [polypeptide binding]; other site
661410002654	response regulator PleD; Reviewed; Region: pleD; PRK09581
661410002655	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410002656	active site
661410002657	phosphorylation site [posttranslational modification]
661410002658	intermolecular recognition site; other site
661410002659	dimerization interface [polypeptide binding]; other site
661410002660	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410002661	active site
661410002662	phosphorylation site [posttranslational modification]
661410002663	intermolecular recognition site; other site
661410002664	dimerization interface [polypeptide binding]; other site
661410002665	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410002666	metal binding site [ion binding]; metal-binding site
661410002667	active site
661410002668	I-site; other site
661410002669	Predicted transcriptional regulator [Transcription]; Region: COG1959
661410002670	Transcriptional regulator; Region: Rrf2; cl17282
661410002671	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
661410002672	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
661410002673	heme-binding site [chemical binding]; other site
661410002674	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
661410002675	FAD binding pocket [chemical binding]; other site
661410002676	FAD binding motif [chemical binding]; other site
661410002677	phosphate binding motif [ion binding]; other site
661410002678	beta-alpha-beta structure motif; other site
661410002679	NAD binding pocket [chemical binding]; other site
661410002680	Heme binding  pocket [chemical binding]; other site
661410002681	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
661410002682	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
661410002683	dimer interface [polypeptide binding]; other site
661410002684	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410002685	catalytic residue [active]
661410002686	META domain; Region: META; pfam03724
661410002687	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
661410002688	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
661410002689	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
661410002690	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410002691	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410002692	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
661410002693	putative dimerization interface [polypeptide binding]; other site
661410002694	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
661410002695	metal binding site [ion binding]; metal-binding site
661410002696	active site
661410002697	phosphoribulokinase; Provisional; Region: PRK15453
661410002698	active site
661410002699	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410002700	H-loop/switch region; other site
661410002701	hypothetical protein; Validated; Region: PRK00110
661410002702	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
661410002703	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
661410002704	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
661410002705	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
661410002706	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
661410002707	oxyanion hole [active]
661410002708	OpgC protein; Region: OpgC_C; pfam10129
661410002709	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
661410002710	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
661410002711	motif II; other site
661410002712	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
661410002713	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
661410002714	substrate binding site [chemical binding]; other site
661410002715	hexamer interface [polypeptide binding]; other site
661410002716	metal binding site [ion binding]; metal-binding site
661410002717	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
661410002718	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
661410002719	Coenzyme A binding pocket [chemical binding]; other site
661410002720	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
661410002721	ornithine decarboxylase; Provisional; Region: PRK13578
661410002722	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
661410002723	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
661410002724	catalytic residue [active]
661410002725	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
661410002726	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
661410002727	MPT binding site; other site
661410002728	trimer interface [polypeptide binding]; other site
661410002729	adenylosuccinate lyase; Provisional; Region: PRK07492
661410002730	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
661410002731	tetramer interface [polypeptide binding]; other site
661410002732	active site
661410002733	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
661410002734	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
661410002735	homodimer interface [polypeptide binding]; other site
661410002736	substrate-cofactor binding pocket; other site
661410002737	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410002738	catalytic residue [active]
661410002739	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
661410002740	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
661410002741	GDP-binding site [chemical binding]; other site
661410002742	ACT binding site; other site
661410002743	IMP binding site; other site
661410002744	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
661410002745	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
661410002746	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
661410002747	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
661410002748	DNA binding residues [nucleotide binding]
661410002749	Transposase; Region: DEDD_Tnp_IS110; pfam01548
661410002750	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
661410002751	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
661410002752	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410002753	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410002754	metal binding site [ion binding]; metal-binding site
661410002755	active site
661410002756	I-site; other site
661410002757	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410002758	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
661410002759	Coenzyme A binding pocket [chemical binding]; other site
661410002760	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
661410002761	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
661410002762	RNA binding surface [nucleotide binding]; other site
661410002763	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
661410002764	active site
661410002765	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
661410002766	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
661410002767	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
661410002768	DNA binding site [nucleotide binding]
661410002769	Int/Topo IB signature motif; other site
661410002770	active site
661410002771	catalytic residues [active]
661410002772	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
661410002773	active site
661410002774	DNA binding site [nucleotide binding]
661410002775	Int/Topo IB signature motif; other site
661410002776	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
661410002777	sequence-specific DNA binding site [nucleotide binding]; other site
661410002778	salt bridge; other site
661410002779	ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049
661410002780	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
661410002781	N-terminal plug; other site
661410002782	ligand-binding site [chemical binding]; other site
661410002783	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
661410002784	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410002785	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
661410002786	Walker A motif; other site
661410002787	ATP binding site [chemical binding]; other site
661410002788	Walker B motif; other site
661410002789	arginine finger; other site
661410002790	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
661410002791	Resolvase, N terminal domain; Region: Resolvase; smart00857
661410002792	catalytic residues [active]
661410002793	Recombinase; Region: Recombinase; pfam07508
661410002794	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
661410002795	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
661410002796	catalytic residues [active]
661410002797	catalytic nucleophile [active]
661410002798	Recombinase; Region: Recombinase; pfam07508
661410002799	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410002800	non-specific DNA binding site [nucleotide binding]; other site
661410002801	salt bridge; other site
661410002802	sequence-specific DNA binding site [nucleotide binding]; other site
661410002803	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
661410002804	putative active site [active]
661410002805	putative metal binding site [ion binding]; other site
661410002806	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410002807	non-specific DNA binding site [nucleotide binding]; other site
661410002808	salt bridge; other site
661410002809	sequence-specific DNA binding site [nucleotide binding]; other site
661410002810	Winged helix-turn helix; Region: HTH_29; pfam13551
661410002811	Integrase core domain; Region: rve; pfam00665
661410002812	Integrase core domain; Region: rve_3; pfam13683
661410002813	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410002814	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
661410002815	Walker A motif; other site
661410002816	ATP binding site [chemical binding]; other site
661410002817	Walker B motif; other site
661410002818	arginine finger; other site
661410002819	Peptidase family M41; Region: Peptidase_M41; pfam01434
661410002820	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
661410002821	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
661410002822	YCII-related domain; Region: YCII; cl00999
661410002823	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
661410002824	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
661410002825	DNA binding residues [nucleotide binding]
661410002826	Fic/DOC family; Region: Fic; pfam02661
661410002827	Fic/DOC family; Region: Fic; cl00960
661410002828	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
661410002829	DNA topoisomerase 2; Provisional; Region: PLN03237
661410002830	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
661410002831	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410002832	active site
661410002833	phosphorylation site [posttranslational modification]
661410002834	intermolecular recognition site; other site
661410002835	dimerization interface [polypeptide binding]; other site
661410002836	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410002837	DNA binding site [nucleotide binding]
661410002838	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410002839	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410002840	dimerization interface [polypeptide binding]; other site
661410002841	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410002842	ATP binding site [chemical binding]; other site
661410002843	Mg2+ binding site [ion binding]; other site
661410002844	G-X-G motif; other site
661410002845	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
661410002846	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410002847	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
661410002848	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
661410002849	Pleiotropic Drug Resistance (PDR) Family protein; Region: 3a01205; TIGR00956
661410002850	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
661410002851	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
661410002852	Abi-like protein; Region: Abi_2; pfam07751
661410002853	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410002854	H+ Antiporter protein; Region: 2A0121; TIGR00900
661410002855	putative substrate translocation pore; other site
661410002856	Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154
661410002857	putative homodimer interface [polypeptide binding]; other site
661410002858	putative homotetramer interface [polypeptide binding]; other site
661410002859	putative metal binding site [ion binding]; other site
661410002860	putative homodimer-homodimer interface [polypeptide binding]; other site
661410002861	putative allosteric switch controlling residues; other site
661410002862	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
661410002863	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410002864	non-specific DNA binding site [nucleotide binding]; other site
661410002865	salt bridge; other site
661410002866	sequence-specific DNA binding site [nucleotide binding]; other site
661410002867	Domain of unknown function (DUF955); Region: DUF955; pfam06114
661410002868	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
661410002869	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
661410002870	Protein export membrane protein; Region: SecD_SecF; cl14618
661410002871	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
661410002872	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410002873	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
661410002874	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
661410002875	catalytic residues [active]
661410002876	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
661410002877	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
661410002878	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
661410002879	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
661410002880	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
661410002881	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
661410002882	Transposase; Region: DEDD_Tnp_IS110; pfam01548
661410002883	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
661410002884	Integrase core domain; Region: rve_3; pfam13683
661410002885	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
661410002886	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
661410002887	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
661410002888	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
661410002889	metal-binding site [ion binding]
661410002890	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
661410002891	Soluble P-type ATPase [General function prediction only]; Region: COG4087
661410002892	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
661410002893	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
661410002894	DNA binding residues [nucleotide binding]
661410002895	dimer interface [polypeptide binding]; other site
661410002896	putative metal binding site [ion binding]; other site
661410002897	YHS domain; Region: YHS; pfam04945
661410002898	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
661410002899	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
661410002900	Soluble P-type ATPase [General function prediction only]; Region: COG4087
661410002901	Domain of unknown function (DUF305); Region: DUF305; cl17794
661410002902	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
661410002903	dimerization interface [polypeptide binding]; other site
661410002904	Domain of unknown function (DUF305); Region: DUF305; cl17794
661410002905	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
661410002906	Protein export membrane protein; Region: SecD_SecF; cl14618
661410002907	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
661410002908	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410002909	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
661410002910	metal-binding site [ion binding]
661410002911	LabA_like proteins; Region: LabA_like; cd06167
661410002912	Protein of unknown function, DUF; Region: DUF411; cl01142
661410002913	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
661410002914	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
661410002915	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410002916	YtkA-like; Region: YtkA; pfam13115
661410002917	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
661410002918	Cenp-O kinetochore centromere component; Region: CENP-O; pfam09496
661410002919	flagellar motor protein MotD; Reviewed; Region: PRK09038
661410002920	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
661410002921	dimer interface [polypeptide binding]; other site
661410002922	active site
661410002923	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
661410002924	Transposase; Region: HTH_Tnp_1; pfam01527
661410002925	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
661410002926	HTH-like domain; Region: HTH_21; pfam13276
661410002927	Integrase core domain; Region: rve; pfam00665
661410002928	Integrase core domain; Region: rve_3; pfam13683
661410002929	Transposase; Region: DEDD_Tnp_IS110; pfam01548
661410002930	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
661410002931	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
661410002932	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
661410002933	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
661410002934	N-terminal plug; other site
661410002935	ligand-binding site [chemical binding]; other site
661410002936	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
661410002937	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
661410002938	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
661410002939	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
661410002940	Sodium Bile acid symporter family; Region: SBF; cl17470
661410002941	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
661410002942	putative DNA binding site [nucleotide binding]; other site
661410002943	putative Zn2+ binding site [ion binding]; other site
661410002944	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
661410002945	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410002946	dimer interface [polypeptide binding]; other site
661410002947	putative CheW interface [polypeptide binding]; other site
661410002948	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
661410002949	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
661410002950	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
661410002951	dimerization interface [polypeptide binding]; other site
661410002952	putative DNA binding site [nucleotide binding]; other site
661410002953	putative Zn2+ binding site [ion binding]; other site
661410002954	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
661410002955	Low molecular weight phosphatase family; Region: LMWPc; cd00115
661410002956	active site
661410002957	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
661410002958	ArsC family; Region: ArsC; pfam03960
661410002959	catalytic residues [active]
661410002960	Transposase; Region: HTH_Tnp_1; pfam01527
661410002961	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
661410002962	HTH-like domain; Region: HTH_21; pfam13276
661410002963	Integrase core domain; Region: rve; pfam00665
661410002964	Integrase core domain; Region: rve_3; pfam13683
661410002965	Transposase; Region: DEDD_Tnp_IS110; pfam01548
661410002966	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
661410002967	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
661410002968	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
661410002969	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
661410002970	YCII-related domain; Region: YCII; cl00999
661410002971	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
661410002972	FOG: CBS domain [General function prediction only]; Region: COG0517
661410002973	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
661410002974	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410002975	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
661410002976	Protein export membrane protein; Region: SecD_SecF; cl14618
661410002977	Domain of unknown function (DUF305); Region: DUF305; cl17794
661410002978	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
661410002979	dimerization interface [polypeptide binding]; other site
661410002980	YHS domain; Region: YHS; pfam04945
661410002981	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
661410002982	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
661410002983	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
661410002984	motif II; other site
661410002985	Protein of unknown function, DUF; Region: DUF411; cl01142
661410002986	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
661410002987	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
661410002988	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
661410002989	putative homodimer interface [polypeptide binding]; other site
661410002990	putative homotetramer interface [polypeptide binding]; other site
661410002991	putative allosteric switch controlling residues; other site
661410002992	putative metal binding site [ion binding]; other site
661410002993	putative homodimer-homodimer interface [polypeptide binding]; other site
661410002994	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
661410002995	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
661410002996	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
661410002997	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
661410002998	N-acetyl-D-glucosamine binding site [chemical binding]; other site
661410002999	catalytic residue [active]
661410003000	Protein of unknown function, DUF; Region: DUF411; cl01142
661410003001	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
661410003002	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
661410003003	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410003004	YtkA-like; Region: YtkA; pfam13115
661410003005	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
661410003006	RNA polymerase sigma factor; Provisional; Region: PRK12539
661410003007	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
661410003008	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
661410003009	DNA binding residues [nucleotide binding]
661410003010	Domain of unknown function (DUF305); Region: DUF305; cl17794
661410003011	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
661410003012	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
661410003013	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
661410003014	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
661410003015	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
661410003016	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
661410003017	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
661410003018	Integrase core domain; Region: rve_3; pfam13683
661410003019	Transcriptional regulators [Transcription]; Region: FadR; COG2186
661410003020	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
661410003021	DNA-binding site [nucleotide binding]; DNA binding site
661410003022	FCD domain; Region: FCD; pfam07729
661410003023	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410003024	D-galactonate transporter; Region: 2A0114; TIGR00893
661410003025	putative substrate translocation pore; other site
661410003026	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
661410003027	tartrate dehydrogenase; Region: TTC; TIGR02089
661410003028	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
661410003029	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
661410003030	MOFRL family; Region: MOFRL; pfam05161
661410003031	pyruvate kinase; Provisional; Region: PRK06247
661410003032	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
661410003033	domain interfaces; other site
661410003034	active site
661410003035	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
661410003036	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
661410003037	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
661410003038	dimerization interface [polypeptide binding]; other site
661410003039	putative DNA binding site [nucleotide binding]; other site
661410003040	putative Zn2+ binding site [ion binding]; other site
661410003041	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
661410003042	Low molecular weight phosphatase family; Region: LMWPc; cd00115
661410003043	active site
661410003044	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
661410003045	ArsC family; Region: ArsC; pfam03960
661410003046	catalytic residues [active]
661410003047	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
661410003048	arsenical-resistance protein; Region: acr3; TIGR00832
661410003049	Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561
661410003050	active site
661410003051	catalytic triad [active]
661410003052	RNA polymerase sigma factor; Provisional; Region: PRK12515
661410003053	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
661410003054	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
661410003055	DNA binding residues [nucleotide binding]
661410003056	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
661410003057	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
661410003058	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410003059	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
661410003060	DNA binding residues [nucleotide binding]
661410003061	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
661410003062	dimer interface [polypeptide binding]; other site
661410003063	putative metal binding site [ion binding]; other site
661410003064	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
661410003065	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
661410003066	metal-binding site [ion binding]
661410003067	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
661410003068	Soluble P-type ATPase [General function prediction only]; Region: COG4087
661410003069	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
661410003070	Abi-like protein; Region: Abi_2; pfam07751
661410003071	HTH-like domain; Region: HTH_21; pfam13276
661410003072	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
661410003073	Integrase core domain; Region: rve; pfam00665
661410003074	Integrase core domain; Region: rve_3; pfam13683
661410003075	Transposase; Region: HTH_Tnp_1; cl17663
661410003076	Transposase; Region: DEDD_Tnp_IS110; pfam01548
661410003077	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
661410003078	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
661410003079	Uncharacterized conserved protein [Function unknown]; Region: COG5489
661410003080	ParB-like nuclease domain; Region: ParBc; pfam02195
661410003081	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
661410003082	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
661410003083	Transposase; Region: DEDD_Tnp_IS110; pfam01548
661410003084	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
661410003085	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
661410003086	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
661410003087	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
661410003088	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
661410003089	Transposase; Region: DEDD_Tnp_IS110; pfam01548
661410003090	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
661410003091	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
661410003092	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
661410003093	Transposase; Region: DEDD_Tnp_IS110; pfam01548
661410003094	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
661410003095	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
661410003096	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
661410003097	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
661410003098	Multicopper oxidase; Region: Cu-oxidase; pfam00394
661410003099	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
661410003100	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
661410003101	Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
661410003102	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
661410003103	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410003104	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
661410003105	ligand binding site [chemical binding]; other site
661410003106	flexible hinge region; other site
661410003107	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
661410003108	putative switch regulator; other site
661410003109	non-specific DNA interactions [nucleotide binding]; other site
661410003110	DNA binding site [nucleotide binding]
661410003111	sequence specific DNA binding site [nucleotide binding]; other site
661410003112	putative cAMP binding site [chemical binding]; other site
661410003113	LTXXQ motif family protein; Region: LTXXQ; pfam07813
661410003114	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
661410003115	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
661410003116	FAD binding pocket [chemical binding]; other site
661410003117	FAD binding motif [chemical binding]; other site
661410003118	phosphate binding motif [ion binding]; other site
661410003119	beta-alpha-beta structure motif; other site
661410003120	NAD binding pocket [chemical binding]; other site
661410003121	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
661410003122	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
661410003123	catalytic loop [active]
661410003124	iron binding site [ion binding]; other site
661410003125	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
661410003126	dimerization interface [polypeptide binding]; other site
661410003127	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
661410003128	Acetokinase family; Region: Acetate_kinase; cl17229
661410003129	propionate/acetate kinase; Provisional; Region: PRK12379
661410003130	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
661410003131	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
661410003132	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
661410003133	Protein of unknown function (DUF3620); Region: DUF3620; cl02233
661410003134	Protein of unknown function (DUF3620); Region: DUF3620; cl02233
661410003135	Protein of unknown function (DUF3620); Region: DUF3620; cl02233
661410003136	HTH-like domain; Region: HTH_21; pfam13276
661410003137	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
661410003138	Integrase core domain; Region: rve; pfam00665
661410003139	Integrase core domain; Region: rve_3; pfam13683
661410003140	Transposase; Region: HTH_Tnp_1; cl17663
661410003141	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
661410003142	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
661410003143	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410003144	putative substrate translocation pore; other site
661410003145	classical (c) SDRs; Region: SDR_c; cd05233
661410003146	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
661410003147	NAD(P) binding site [chemical binding]; other site
661410003148	active site
661410003149	Uncharacterized conserved protein [Function unknown]; Region: COG4925
661410003150	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
661410003151	Strictosidine synthase; Region: Str_synth; pfam03088
661410003152	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
661410003153	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
661410003154	classical (c) SDRs; Region: SDR_c; cd05233
661410003155	NAD(P) binding site [chemical binding]; other site
661410003156	active site
661410003157	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410003158	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410003159	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
661410003160	putative effector binding pocket; other site
661410003161	putative dimerization interface [polypeptide binding]; other site
661410003162	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
661410003163	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
661410003164	catalytic loop [active]
661410003165	iron binding site [ion binding]; other site
661410003166	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
661410003167	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
661410003168	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
661410003169	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
661410003170	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
661410003171	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
661410003172	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
661410003173	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
661410003174	GTPase/Zn-binding domain interface [polypeptide binding]; other site
661410003175	GTP/Mg2+ binding site [chemical binding]; other site
661410003176	G4 box; other site
661410003177	G5 box; other site
661410003178	G1 box; other site
661410003179	Switch I region; other site
661410003180	G2 box; other site
661410003181	G3 box; other site
661410003182	Switch II region; other site
661410003183	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
661410003184	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
661410003185	putative NAD(P) binding site [chemical binding]; other site
661410003186	active site
661410003187	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
661410003188	MFS_1 like family; Region: MFS_1_like; pfam12832
661410003189	primosome assembly protein PriA; Validated; Region: PRK05580
661410003190	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
661410003191	ATP binding site [chemical binding]; other site
661410003192	putative Mg++ binding site [ion binding]; other site
661410003193	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
661410003194	short chain dehydrogenase; Provisional; Region: PRK07109
661410003195	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
661410003196	putative NAD(P) binding site [chemical binding]; other site
661410003197	active site
661410003198	Isochorismatase family; Region: Isochorismatase; pfam00857
661410003199	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
661410003200	catalytic triad [active]
661410003201	conserved cis-peptide bond; other site
661410003202	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
661410003203	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
661410003204	NAD binding site [chemical binding]; other site
661410003205	catalytic Zn binding site [ion binding]; other site
661410003206	structural Zn binding site [ion binding]; other site
661410003207	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
661410003208	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
661410003209	short chain dehydrogenase; Provisional; Region: PRK06701
661410003210	NAD binding site [chemical binding]; other site
661410003211	metal binding site [ion binding]; metal-binding site
661410003212	active site
661410003213	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410003214	NAD(P) binding site [chemical binding]; other site
661410003215	active site
661410003216	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
661410003217	ABC1 family; Region: ABC1; pfam03109
661410003218	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
661410003219	active site
661410003220	ATP binding site [chemical binding]; other site
661410003221	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
661410003222	Peptidase family M23; Region: Peptidase_M23; pfam01551
661410003223	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
661410003224	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
661410003225	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
661410003226	active site
661410003227	HIGH motif; other site
661410003228	nucleotide binding site [chemical binding]; other site
661410003229	active site
661410003230	KMSKS motif; other site
661410003231	heat shock protein 90; Provisional; Region: PRK05218
661410003232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410003233	ATP binding site [chemical binding]; other site
661410003234	Mg2+ binding site [ion binding]; other site
661410003235	G-X-G motif; other site
661410003236	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
661410003237	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
661410003238	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
661410003239	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
661410003240	DAK2 domain; Region: Dak2; pfam02734
661410003241	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410003242	S-adenosylmethionine binding site [chemical binding]; other site
661410003243	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
661410003244	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410003245	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410003246	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
661410003247	active site
661410003248	putative homodimer interface [polypeptide binding]; other site
661410003249	SAM binding site [chemical binding]; other site
661410003250	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
661410003251	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410003252	S-adenosylmethionine binding site [chemical binding]; other site
661410003253	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
661410003254	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410003255	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410003256	metal binding site [ion binding]; metal-binding site
661410003257	active site
661410003258	I-site; other site
661410003259	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410003260	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410003261	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
661410003262	dimerization interface [polypeptide binding]; other site
661410003263	Predicted membrane protein [Function unknown]; Region: COG4125
661410003264	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
661410003265	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
661410003266	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
661410003267	active site
661410003268	SAM binding site [chemical binding]; other site
661410003269	homodimer interface [polypeptide binding]; other site
661410003270	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
661410003271	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
661410003272	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
661410003273	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
661410003274	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410003275	non-specific DNA binding site [nucleotide binding]; other site
661410003276	salt bridge; other site
661410003277	sequence-specific DNA binding site [nucleotide binding]; other site
661410003278	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
661410003279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410003280	Major Facilitator Superfamily; Region: MFS_1; pfam07690
661410003281	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
661410003282	Bacterial sugar transferase; Region: Bac_transf; pfam02397
661410003283	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
661410003284	metal binding site 2 [ion binding]; metal-binding site
661410003285	putative DNA binding helix; other site
661410003286	metal binding site 1 [ion binding]; metal-binding site
661410003287	dimer interface [polypeptide binding]; other site
661410003288	structural Zn2+ binding site [ion binding]; other site
661410003289	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
661410003290	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
661410003291	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
661410003292	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
661410003293	ABC-ATPase subunit  interface; other site
661410003294	dimer interface [polypeptide binding]; other site
661410003295	putative PBP binding regions; other site
661410003296	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
661410003297	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
661410003298	putative active site [active]
661410003299	putative PHP Thumb interface [polypeptide binding]; other site
661410003300	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
661410003301	generic binding surface II; other site
661410003302	generic binding surface I; other site
661410003303	lytic murein transglycosylase; Region: MltB_2; TIGR02283
661410003304	murein hydrolase B; Provisional; Region: PRK10760; cl17906
661410003305	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
661410003306	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
661410003307	putative active site pocket [active]
661410003308	dimerization interface [polypeptide binding]; other site
661410003309	putative catalytic residue [active]
661410003310	Recombination protein O N terminal; Region: RecO_N; pfam11967
661410003311	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
661410003312	Recombination protein O C terminal; Region: RecO_C; pfam02565
661410003313	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
661410003314	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
661410003315	CAP-like domain; other site
661410003316	active site
661410003317	primary dimer interface [polypeptide binding]; other site
661410003318	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
661410003319	rRNA binding site [nucleotide binding]; other site
661410003320	predicted 30S ribosome binding site; other site
661410003321	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
661410003322	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
661410003323	dimerization interface [polypeptide binding]; other site
661410003324	ligand binding site [chemical binding]; other site
661410003325	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
661410003326	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
661410003327	XdhC Rossmann domain; Region: XdhC_C; pfam13478
661410003328	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
661410003329	MPT binding site; other site
661410003330	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
661410003331	Ligand binding site; other site
661410003332	metal-binding site
661410003333	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
661410003334	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
661410003335	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
661410003336	active site
661410003337	cosubstrate binding site; other site
661410003338	substrate binding site [chemical binding]; other site
661410003339	catalytic site [active]
661410003340	Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911
661410003341	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
661410003342	classical (c) SDRs; Region: SDR_c; cd05233
661410003343	NAD(P) binding site [chemical binding]; other site
661410003344	active site
661410003345	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
661410003346	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
661410003347	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
661410003348	Walker A/P-loop; other site
661410003349	ATP binding site [chemical binding]; other site
661410003350	Q-loop/lid; other site
661410003351	ABC transporter signature motif; other site
661410003352	Walker B; other site
661410003353	D-loop; other site
661410003354	H-loop/switch region; other site
661410003355	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
661410003356	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
661410003357	FtsX-like permease family; Region: FtsX; pfam02687
661410003358	prolyl-tRNA synthetase; Provisional; Region: PRK12325
661410003359	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
661410003360	dimer interface [polypeptide binding]; other site
661410003361	motif 1; other site
661410003362	active site
661410003363	motif 2; other site
661410003364	motif 3; other site
661410003365	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
661410003366	anticodon binding site; other site
661410003367	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
661410003368	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
661410003369	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
661410003370	dimer interface [polypeptide binding]; other site
661410003371	substrate binding site [chemical binding]; other site
661410003372	metal binding site [ion binding]; metal-binding site
661410003373	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
661410003374	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
661410003375	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
661410003376	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
661410003377	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
661410003378	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
661410003379	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
661410003380	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
661410003381	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
661410003382	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
661410003383	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
661410003384	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
661410003385	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
661410003386	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
661410003387	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
661410003388	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
661410003389	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
661410003390	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
661410003391	4Fe-4S binding domain; Region: Fer4; pfam00037
661410003392	4Fe-4S binding domain; Region: Fer4; pfam00037
661410003393	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
661410003394	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
661410003395	NADH dehydrogenase subunit G; Validated; Region: PRK09130
661410003396	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
661410003397	catalytic loop [active]
661410003398	iron binding site [ion binding]; other site
661410003399	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
661410003400	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
661410003401	molybdopterin cofactor binding site; other site
661410003402	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
661410003403	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
661410003404	SLBB domain; Region: SLBB; pfam10531
661410003405	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
661410003406	NADH dehydrogenase subunit E; Provisional; Region: PRK12373
661410003407	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
661410003408	putative dimer interface [polypeptide binding]; other site
661410003409	[2Fe-2S] cluster binding site [ion binding]; other site
661410003410	Uncharacterized conserved protein [Function unknown]; Region: COG3743
661410003411	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
661410003412	NADH dehydrogenase subunit D; Validated; Region: PRK06075
661410003413	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
661410003414	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
661410003415	NADH dehydrogenase subunit B; Validated; Region: PRK06411
661410003416	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
661410003417	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
661410003418	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
661410003419	pseudoazurin; Region: pseudoazurin; TIGR02375
661410003420	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
661410003421	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
661410003422	ATP-grasp domain; Region: ATP-grasp_4; cl17255
661410003423	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
661410003424	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
661410003425	ATP-grasp domain; Region: ATP-grasp_4; cl17255
661410003426	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
661410003427	IMP binding site; other site
661410003428	dimer interface [polypeptide binding]; other site
661410003429	partial ornithine binding site; other site
661410003430	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
661410003431	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
661410003432	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
661410003433	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
661410003434	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
661410003435	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
661410003436	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
661410003437	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
661410003438	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410003439	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410003440	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
661410003441	putative effector binding pocket; other site
661410003442	dimerization interface [polypeptide binding]; other site
661410003443	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
661410003444	Dehydroquinase class II; Region: DHquinase_II; pfam01220
661410003445	trimer interface [polypeptide binding]; other site
661410003446	active site
661410003447	dimer interface [polypeptide binding]; other site
661410003448	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
661410003449	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
661410003450	carboxyltransferase (CT) interaction site; other site
661410003451	biotinylation site [posttranslational modification]; other site
661410003452	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
661410003453	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
661410003454	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
661410003455	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
661410003456	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
661410003457	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
661410003458	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
661410003459	WHG domain; Region: WHG; pfam13305
661410003460	Domain of unknown function (DUF4188); Region: DUF4188; pfam13826
661410003461	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765
661410003462	NADH dehydrogenase; Validated; Region: PRK08183
661410003463	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
661410003464	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
661410003465	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
661410003466	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
661410003467	active site
661410003468	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
661410003469	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
661410003470	TSCPD domain; Region: TSCPD; pfam12637
661410003471	DEAD-like helicases superfamily; Region: DEXDc; smart00487
661410003472	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
661410003473	ATP binding site [chemical binding]; other site
661410003474	putative Mg++ binding site [ion binding]; other site
661410003475	nucleotide binding region [chemical binding]; other site
661410003476	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
661410003477	ATP-binding site [chemical binding]; other site
661410003478	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
661410003479	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
661410003480	Transposase; Region: DDE_Tnp_ISL3; pfam01610
661410003481	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
661410003482	Transposase; Region: HTH_Tnp_1; cl17663
661410003483	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
661410003484	DNA-binding interface [nucleotide binding]; DNA binding site
661410003485	putative transposase OrfB; Reviewed; Region: PHA02517
661410003486	HTH-like domain; Region: HTH_21; pfam13276
661410003487	Integrase core domain; Region: rve; pfam00665
661410003488	Integrase core domain; Region: rve_3; pfam13683
661410003489	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
661410003490	Cation efflux family; Region: Cation_efflux; cl00316
661410003491	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
661410003492	classical (c) SDRs; Region: SDR_c; cd05233
661410003493	NAD(P) binding site [chemical binding]; other site
661410003494	active site
661410003495	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410003496	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410003497	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480
661410003498	putative effector binding pocket; other site
661410003499	putative dimerization interface [polypeptide binding]; other site
661410003500	FtsH Extracellular; Region: FtsH_ext; pfam06480
661410003501	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
661410003502	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410003503	Walker A motif; other site
661410003504	ATP binding site [chemical binding]; other site
661410003505	Walker B motif; other site
661410003506	arginine finger; other site
661410003507	Peptidase family M41; Region: Peptidase_M41; pfam01434
661410003508	FOG: CBS domain [General function prediction only]; Region: COG0517
661410003509	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
661410003510	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
661410003511	Peptidase family M50; Region: Peptidase_M50; pfam02163
661410003512	active site
661410003513	putative substrate binding region [chemical binding]; other site
661410003514	FOG: CBS domain [General function prediction only]; Region: COG0517
661410003515	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639
661410003516	Found in ATP-dependent protease La (LON); Region: LON; smart00464
661410003517	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
661410003518	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410003519	Walker A motif; other site
661410003520	ATP binding site [chemical binding]; other site
661410003521	Walker B motif; other site
661410003522	arginine finger; other site
661410003523	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
661410003524	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
661410003525	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
661410003526	putative dimer interface [polypeptide binding]; other site
661410003527	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
661410003528	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
661410003529	chaperone protein DnaJ; Provisional; Region: PRK14299
661410003530	HSP70 interaction site [polypeptide binding]; other site
661410003531	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
661410003532	substrate binding site [polypeptide binding]; other site
661410003533	dimer interface [polypeptide binding]; other site
661410003534	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
661410003535	30S subunit binding site; other site
661410003536	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
661410003537	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
661410003538	putative dimer interface [polypeptide binding]; other site
661410003539	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
661410003540	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
661410003541	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
661410003542	active site
661410003543	catalytic site [active]
661410003544	Integrase core domain; Region: rve_3; pfam13683
661410003545	SPW repeat; Region: SPW; pfam03779
661410003546	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
661410003547	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
661410003548	Clp amino terminal domain; Region: Clp_N; pfam02861
661410003549	Clp amino terminal domain; Region: Clp_N; pfam02861
661410003550	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410003551	Walker A motif; other site
661410003552	ATP binding site [chemical binding]; other site
661410003553	Walker B motif; other site
661410003554	arginine finger; other site
661410003555	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410003556	Walker A motif; other site
661410003557	ATP binding site [chemical binding]; other site
661410003558	Walker B motif; other site
661410003559	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
661410003560	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410003561	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
661410003562	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410003563	Histidine kinase; Region: HisKA_2; pfam07568
661410003564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410003565	ATP binding site [chemical binding]; other site
661410003566	Mg2+ binding site [ion binding]; other site
661410003567	G-X-G motif; other site
661410003568	thioredoxin 2; Provisional; Region: PRK10996
661410003569	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
661410003570	catalytic residues [active]
661410003571	SPW repeat; Region: SPW; pfam03779
661410003572	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
661410003573	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
661410003574	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
661410003575	putative dimer interface [polypeptide binding]; other site
661410003576	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
661410003577	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
661410003578	putative dimer interface [polypeptide binding]; other site
661410003579	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
661410003580	putative active site [active]
661410003581	catalytic site [active]
661410003582	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
661410003583	PLD-like domain; Region: PLDc_2; pfam13091
661410003584	putative active site [active]
661410003585	catalytic site [active]
661410003586	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
661410003587	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
661410003588	putative dimer interface [polypeptide binding]; other site
661410003589	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
661410003590	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
661410003591	putative dimer interface [polypeptide binding]; other site
661410003592	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
661410003593	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410003594	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410003595	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410003596	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
661410003597	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
661410003598	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410003599	Walker A motif; other site
661410003600	ATP binding site [chemical binding]; other site
661410003601	Walker B motif; other site
661410003602	arginine finger; other site
661410003603	Peptidase family M41; Region: Peptidase_M41; pfam01434
661410003604	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
661410003605	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
661410003606	Integrase core domain; Region: rve; pfam00665
661410003607	Integrase core domain; Region: rve_3; cl15866
661410003608	TIGR03809 family protein; Region: TIGR03809
661410003609	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410003610	AAA domain; Region: AAA_22; pfam13401
661410003611	Walker A motif; other site
661410003612	ATP binding site [chemical binding]; other site
661410003613	Walker B motif; other site
661410003614	arginine finger; other site
661410003615	TniQ; Region: TniQ; pfam06527
661410003616	Ion channel; Region: Ion_trans_2; pfam07885
661410003617	Predicted membrane protein [Function unknown]; Region: COG2323
661410003618	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
661410003619	homotrimer interaction site [polypeptide binding]; other site
661410003620	putative active site [active]
661410003621	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
661410003622	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
661410003623	active site
661410003624	FMN binding site [chemical binding]; other site
661410003625	substrate binding site [chemical binding]; other site
661410003626	putative catalytic residue [active]
661410003627	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410003628	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410003629	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
661410003630	putative effector binding pocket; other site
661410003631	dimerization interface [polypeptide binding]; other site
661410003632	PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417
661410003633	primary metal binding site; other site
661410003634	catalytic residues [active]
661410003635	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410003636	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410003637	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
661410003638	dimerization interface [polypeptide binding]; other site
661410003639	NMT1/THI5 like; Region: NMT1; pfam09084
661410003640	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
661410003641	membrane-bound complex binding site; other site
661410003642	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
661410003643	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410003644	dimer interface [polypeptide binding]; other site
661410003645	conserved gate region; other site
661410003646	putative PBP binding loops; other site
661410003647	ABC-ATPase subunit interface; other site
661410003648	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
661410003649	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
661410003650	Walker A/P-loop; other site
661410003651	ATP binding site [chemical binding]; other site
661410003652	Q-loop/lid; other site
661410003653	ABC transporter signature motif; other site
661410003654	Walker B; other site
661410003655	D-loop; other site
661410003656	H-loop/switch region; other site
661410003657	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
661410003658	allophanate hydrolase; Provisional; Region: PRK08186
661410003659	Amidase; Region: Amidase; cl11426
661410003660	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
661410003661	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
661410003662	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
661410003663	NAD(P) binding site [chemical binding]; other site
661410003664	active site
661410003665	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410003666	GAF domain; Region: GAF; pfam01590
661410003667	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410003668	putative active site [active]
661410003669	PAS fold; Region: PAS_3; pfam08447
661410003670	heme pocket [chemical binding]; other site
661410003671	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410003672	HWE histidine kinase; Region: HWE_HK; smart00911
661410003673	C factor cell-cell signaling protein; Provisional; Region: PRK09009
661410003674	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410003675	NAD(P) binding site [chemical binding]; other site
661410003676	active site
661410003677	Protein of unknown function (DUF938); Region: DUF938; pfam06080
661410003678	Methyltransferase domain; Region: Methyltransf_11; pfam08241
661410003679	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
661410003680	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
661410003681	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410003682	Origin recognition complex subunit 2; Region: ORC2; pfam04084
661410003683	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
661410003684	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
661410003685	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
661410003686	putative active site [active]
661410003687	putative metal binding site [ion binding]; other site
661410003688	Domain of unknown function (DUF892); Region: DUF892; pfam05974
661410003689	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
661410003690	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
661410003691	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
661410003692	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
661410003693	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
661410003694	Protein phosphatase 2C; Region: PP2C; pfam00481
661410003695	active site
661410003696	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
661410003697	Catalytic domain of Protein Kinases; Region: PKc; cd00180
661410003698	active site
661410003699	ATP binding site [chemical binding]; other site
661410003700	substrate binding site [chemical binding]; other site
661410003701	activation loop (A-loop); other site
661410003702	Cellulose synthase-like protein; Region: PLN02893
661410003703	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
661410003704	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
661410003705	DXD motif; other site
661410003706	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
661410003707	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410003708	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
661410003709	HTH-like domain; Region: HTH_21; pfam13276
661410003710	Integrase core domain; Region: rve; pfam00665
661410003711	Integrase core domain; Region: rve_3; pfam13683
661410003712	Transposase; Region: HTH_Tnp_1; pfam01527
661410003713	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
661410003714	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
661410003715	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
661410003716	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
661410003717	HlyD family secretion protein; Region: HlyD; pfam00529
661410003718	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410003719	Predicted transporter component [General function prediction only]; Region: COG2391
661410003720	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
661410003721	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
661410003722	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
661410003723	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
661410003724	dimerization interface [polypeptide binding]; other site
661410003725	putative DNA binding site [nucleotide binding]; other site
661410003726	putative Zn2+ binding site [ion binding]; other site
661410003727	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
661410003728	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
661410003729	Walker A/P-loop; other site
661410003730	ATP binding site [chemical binding]; other site
661410003731	Q-loop/lid; other site
661410003732	ABC transporter signature motif; other site
661410003733	Walker B; other site
661410003734	D-loop; other site
661410003735	H-loop/switch region; other site
661410003736	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
661410003737	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410003738	dimer interface [polypeptide binding]; other site
661410003739	conserved gate region; other site
661410003740	putative PBP binding loops; other site
661410003741	ABC-ATPase subunit interface; other site
661410003742	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
661410003743	NMT1-like family; Region: NMT1_2; pfam13379
661410003744	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
661410003745	Rubredoxin; Region: Rubredoxin; pfam00301
661410003746	iron binding site [ion binding]; other site
661410003747	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
661410003748	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
661410003749	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
661410003750	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
661410003751	OsmC-like protein; Region: OsmC; pfam02566
661410003752	Nif-specific regulatory protein; Region: nifA; TIGR01817
661410003753	GAF domain; Region: GAF; pfam01590
661410003754	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410003755	Walker A motif; other site
661410003756	ATP binding site [chemical binding]; other site
661410003757	Walker B motif; other site
661410003758	arginine finger; other site
661410003759	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
661410003760	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
661410003761	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
661410003762	conserved cys residue [active]
661410003763	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
661410003764	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
661410003765	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
661410003766	conserved cys residue [active]
661410003767	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
661410003768	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
661410003769	Na binding site [ion binding]; other site
661410003770	Protein of unknown function, DUF485; Region: DUF485; pfam04341
661410003771	Predicted amidohydrolase [General function prediction only]; Region: COG0388
661410003772	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
661410003773	putative active site [active]
661410003774	catalytic triad [active]
661410003775	putative dimer interface [polypeptide binding]; other site
661410003776	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410003777	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410003778	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
661410003779	dimerization interface [polypeptide binding]; other site
661410003780	RNA polymerase sigma factor; Provisional; Region: PRK12547
661410003781	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
661410003782	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
661410003783	DNA binding residues [nucleotide binding]
661410003784	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
661410003785	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410003786	non-specific DNA binding site [nucleotide binding]; other site
661410003787	salt bridge; other site
661410003788	sequence-specific DNA binding site [nucleotide binding]; other site
661410003789	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
661410003790	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
661410003791	Walker A/P-loop; other site
661410003792	ATP binding site [chemical binding]; other site
661410003793	Q-loop/lid; other site
661410003794	ABC transporter signature motif; other site
661410003795	Walker B; other site
661410003796	D-loop; other site
661410003797	H-loop/switch region; other site
661410003798	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
661410003799	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410003800	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410003801	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
661410003802	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
661410003803	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
661410003804	DXD motif; other site
661410003805	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
661410003806	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
661410003807	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410003808	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
661410003809	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
661410003810	Walker A/P-loop; other site
661410003811	ATP binding site [chemical binding]; other site
661410003812	Q-loop/lid; other site
661410003813	ABC transporter signature motif; other site
661410003814	Walker B; other site
661410003815	D-loop; other site
661410003816	H-loop/switch region; other site
661410003817	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410003818	dimer interface [polypeptide binding]; other site
661410003819	conserved gate region; other site
661410003820	putative PBP binding loops; other site
661410003821	ABC-ATPase subunit interface; other site
661410003822	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
661410003823	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
661410003824	substrate binding pocket [chemical binding]; other site
661410003825	membrane-bound complex binding site; other site
661410003826	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
661410003827	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
661410003828	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
661410003829	active site
661410003830	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
661410003831	active site
661410003832	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
661410003833	dimer interface [polypeptide binding]; other site
661410003834	non-prolyl cis peptide bond; other site
661410003835	insertion regions; other site
661410003836	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
661410003837	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
661410003838	membrane-bound complex binding site; other site
661410003839	hinge residues; other site
661410003840	Cupin domain; Region: Cupin_2; cl17218
661410003841	serine acetyltransferase; Provisional; Region: cysE; PRK11132
661410003842	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
661410003843	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
661410003844	trimer interface [polypeptide binding]; other site
661410003845	active site
661410003846	substrate binding site [chemical binding]; other site
661410003847	CoA binding site [chemical binding]; other site
661410003848	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410003849	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410003850	ligand binding site [chemical binding]; other site
661410003851	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
661410003852	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
661410003853	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
661410003854	catalytic residue [active]
661410003855	Hint domain; Region: Hint_2; pfam13403
661410003856	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
661410003857	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
661410003858	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
661410003859	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
661410003860	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
661410003861	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
661410003862	DNA-binding site [nucleotide binding]; DNA binding site
661410003863	RNA-binding motif; other site
661410003864	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
661410003865	GAF domain; Region: GAF; pfam01590
661410003866	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410003867	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410003868	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
661410003869	putative active site [active]
661410003870	heme pocket [chemical binding]; other site
661410003871	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410003872	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
661410003873	putative active site [active]
661410003874	heme pocket [chemical binding]; other site
661410003875	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410003876	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
661410003877	putative active site [active]
661410003878	heme pocket [chemical binding]; other site
661410003879	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410003880	putative active site [active]
661410003881	heme pocket [chemical binding]; other site
661410003882	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410003883	PAS fold; Region: PAS_3; pfam08447
661410003884	putative active site [active]
661410003885	heme pocket [chemical binding]; other site
661410003886	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410003887	HWE histidine kinase; Region: HWE_HK; pfam07536
661410003888	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
661410003889	myosin-cross-reactive antigen; Provisional; Region: PRK13977
661410003890	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
661410003891	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
661410003892	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727
661410003893	dimer interface [polypeptide binding]; other site
661410003894	catalytic residues [active]
661410003895	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
661410003896	UreF; Region: UreF; pfam01730
661410003897	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
661410003898	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
661410003899	alpha-gamma subunit interface [polypeptide binding]; other site
661410003900	beta-gamma subunit interface [polypeptide binding]; other site
661410003901	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
661410003902	alpha-beta subunit interface [polypeptide binding]; other site
661410003903	urease subunit alpha; Reviewed; Region: ureC; PRK13308
661410003904	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
661410003905	subunit interactions [polypeptide binding]; other site
661410003906	active site
661410003907	flap region; other site
661410003908	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
661410003909	UreD urease accessory protein; Region: UreD; pfam01774
661410003910	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
661410003911	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
661410003912	putative ligand binding site [chemical binding]; other site
661410003913	Predicted membrane protein [Function unknown]; Region: COG3503
661410003914	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
661410003915	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
661410003916	N-terminal plug; other site
661410003917	ligand-binding site [chemical binding]; other site
661410003918	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
661410003919	SnoaL-like domain; Region: SnoaL_2; pfam12680
661410003920	OsmC-like protein; Region: OsmC; pfam02566
661410003921	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410003922	PAS domain; Region: PAS_9; pfam13426
661410003923	putative active site [active]
661410003924	heme pocket [chemical binding]; other site
661410003925	formyl-coenzyme A transferase; Provisional; Region: PRK05398
661410003926	CoA-transferase family III; Region: CoA_transf_3; pfam02515
661410003927	putative hydrolase; Provisional; Region: PRK11460
661410003928	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
661410003929	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
661410003930	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
661410003931	PYR/PP interface [polypeptide binding]; other site
661410003932	dimer interface [polypeptide binding]; other site
661410003933	TPP binding site [chemical binding]; other site
661410003934	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
661410003935	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
661410003936	TPP-binding site; other site
661410003937	dimer interface [polypeptide binding]; other site
661410003938	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
661410003939	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
661410003940	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410003941	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
661410003942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410003943	putative substrate translocation pore; other site
661410003944	FOG: CBS domain [General function prediction only]; Region: COG0517
661410003945	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
661410003946	Zeta toxin; Region: Zeta_toxin; pfam06414
661410003947	SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; cl17853
661410003948	hypothetical protein; Provisional; Region: PRK06194
661410003949	formyl-coenzyme A transferase; Provisional; Region: PRK05398
661410003950	CoA-transferase family III; Region: CoA_transf_3; pfam02515
661410003951	Transcriptional regulators [Transcription]; Region: GntR; COG1802
661410003952	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
661410003953	DNA-binding site [nucleotide binding]; DNA binding site
661410003954	FCD domain; Region: FCD; pfam07729
661410003955	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
661410003956	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
661410003957	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
661410003958	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
661410003959	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
661410003960	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
661410003961	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410003962	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
661410003963	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
661410003964	active site
661410003965	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
661410003966	Ligand Binding Site [chemical binding]; other site
661410003967	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
661410003968	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
661410003969	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
661410003970	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
661410003971	active site
661410003972	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410003973	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
661410003974	putative ADP-binding pocket [chemical binding]; other site
661410003975	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
661410003976	active site
661410003977	GIY-YIG motif/motif A; other site
661410003978	catalytic site [active]
661410003979	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
661410003980	regulatory protein interface [polypeptide binding]; other site
661410003981	active site
661410003982	regulatory phosphorylation site [posttranslational modification]; other site
661410003983	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
661410003984	active pocket/dimerization site; other site
661410003985	active site
661410003986	phosphorylation site [posttranslational modification]
661410003987	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
661410003988	active site
661410003989	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
661410003990	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410003991	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410003992	dimerization interface [polypeptide binding]; other site
661410003993	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410003994	dimer interface [polypeptide binding]; other site
661410003995	phosphorylation site [posttranslational modification]
661410003996	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410003997	ATP binding site [chemical binding]; other site
661410003998	Mg2+ binding site [ion binding]; other site
661410003999	G-X-G motif; other site
661410004000	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
661410004001	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410004002	active site
661410004003	phosphorylation site [posttranslational modification]
661410004004	intermolecular recognition site; other site
661410004005	dimerization interface [polypeptide binding]; other site
661410004006	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410004007	DNA binding site [nucleotide binding]
661410004008	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
661410004009	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
661410004010	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
661410004011	GTP-binding protein LepA; Provisional; Region: PRK05433
661410004012	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
661410004013	G1 box; other site
661410004014	putative GEF interaction site [polypeptide binding]; other site
661410004015	GTP/Mg2+ binding site [chemical binding]; other site
661410004016	Switch I region; other site
661410004017	G2 box; other site
661410004018	G3 box; other site
661410004019	Switch II region; other site
661410004020	G4 box; other site
661410004021	G5 box; other site
661410004022	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
661410004023	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
661410004024	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
661410004025	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410004026	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410004027	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
661410004028	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
661410004029	Transglycosylase; Region: Transgly; pfam00912
661410004030	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
661410004031	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
661410004032	Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344
661410004033	flagellin; Reviewed; Region: PRK12688
661410004034	flagellin; Reviewed; Region: PRK12688
661410004035	Flagellar protein FlbT; Region: FlbT; pfam07378
661410004036	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
661410004037	Predicted membrane protein [Function unknown]; Region: COG4763
661410004038	Acyltransferase family; Region: Acyl_transf_3; pfam01757
661410004039	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
661410004040	HD domain; Region: HD_5; pfam13487
661410004041	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
661410004042	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
661410004043	Zn2+ binding site [ion binding]; other site
661410004044	Mg2+ binding site [ion binding]; other site
661410004045	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
661410004046	Putative phosphatase (DUF442); Region: DUF442; cl17385
661410004047	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
661410004048	active site
661410004049	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
661410004050	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
661410004051	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
661410004052	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
661410004053	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410004054	active site
661410004055	phosphorylation site [posttranslational modification]
661410004056	intermolecular recognition site; other site
661410004057	dimerization interface [polypeptide binding]; other site
661410004058	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410004059	Walker A motif; other site
661410004060	ATP binding site [chemical binding]; other site
661410004061	Walker B motif; other site
661410004062	arginine finger; other site
661410004063	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
661410004064	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
661410004065	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410004066	dimer interface [polypeptide binding]; other site
661410004067	phosphorylation site [posttranslational modification]
661410004068	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410004069	ATP binding site [chemical binding]; other site
661410004070	Mg2+ binding site [ion binding]; other site
661410004071	G-X-G motif; other site
661410004072	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
661410004073	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
661410004074	Walker A/P-loop; other site
661410004075	ATP binding site [chemical binding]; other site
661410004076	Q-loop/lid; other site
661410004077	ABC transporter signature motif; other site
661410004078	Walker B; other site
661410004079	D-loop; other site
661410004080	H-loop/switch region; other site
661410004081	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
661410004082	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410004083	dimer interface [polypeptide binding]; other site
661410004084	conserved gate region; other site
661410004085	putative PBP binding loops; other site
661410004086	ABC-ATPase subunit interface; other site
661410004087	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
661410004088	NMT1/THI5 like; Region: NMT1; pfam09084
661410004089	substrate binding pocket [chemical binding]; other site
661410004090	membrane-bound complex binding site; other site
661410004091	septum formation inhibitor; Reviewed; Region: minC; PRK05177
661410004092	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
661410004093	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
661410004094	Predicted membrane protein [Function unknown]; Region: COG4325
661410004095	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
661410004096	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
661410004097	G1 box; other site
661410004098	putative GEF interaction site [polypeptide binding]; other site
661410004099	GTP/Mg2+ binding site [chemical binding]; other site
661410004100	Switch I region; other site
661410004101	G2 box; other site
661410004102	G3 box; other site
661410004103	Switch II region; other site
661410004104	G4 box; other site
661410004105	G5 box; other site
661410004106	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
661410004107	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
661410004108	CHASE3 domain; Region: CHASE3; pfam05227
661410004109	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
661410004110	dimerization interface [polypeptide binding]; other site
661410004111	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410004112	dimer interface [polypeptide binding]; other site
661410004113	putative CheW interface [polypeptide binding]; other site
661410004114	septum formation inhibitor; Reviewed; Region: minC; PRK05177
661410004115	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
661410004116	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
661410004117	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
661410004118	Switch I; other site
661410004119	Switch II; other site
661410004120	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
661410004121	Cytochrome P450; Region: p450; cl12078
661410004122	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
661410004123	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
661410004124	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
661410004125	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
661410004126	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
661410004127	probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885
661410004128	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
661410004129	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
661410004130	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495
661410004131	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
661410004132	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410004133	dimer interface [polypeptide binding]; other site
661410004134	conserved gate region; other site
661410004135	putative PBP binding loops; other site
661410004136	ABC-ATPase subunit interface; other site
661410004137	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
661410004138	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410004139	dimer interface [polypeptide binding]; other site
661410004140	conserved gate region; other site
661410004141	putative PBP binding loops; other site
661410004142	ABC-ATPase subunit interface; other site
661410004143	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
661410004144	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
661410004145	Walker A/P-loop; other site
661410004146	ATP binding site [chemical binding]; other site
661410004147	Q-loop/lid; other site
661410004148	ABC transporter signature motif; other site
661410004149	Walker B; other site
661410004150	D-loop; other site
661410004151	H-loop/switch region; other site
661410004152	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
661410004153	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
661410004154	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
661410004155	Walker A/P-loop; other site
661410004156	ATP binding site [chemical binding]; other site
661410004157	Q-loop/lid; other site
661410004158	ABC transporter signature motif; other site
661410004159	Walker B; other site
661410004160	D-loop; other site
661410004161	H-loop/switch region; other site
661410004162	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
661410004163	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
661410004164	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
661410004165	tetrameric interface [polypeptide binding]; other site
661410004166	NAD binding site [chemical binding]; other site
661410004167	catalytic residues [active]
661410004168	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
661410004169	putative hydrophobic ligand binding site [chemical binding]; other site
661410004170	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
661410004171	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
661410004172	Walker A/P-loop; other site
661410004173	ATP binding site [chemical binding]; other site
661410004174	Q-loop/lid; other site
661410004175	ABC transporter signature motif; other site
661410004176	Walker B; other site
661410004177	D-loop; other site
661410004178	H-loop/switch region; other site
661410004179	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
661410004180	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
661410004181	Walker A/P-loop; other site
661410004182	ATP binding site [chemical binding]; other site
661410004183	Q-loop/lid; other site
661410004184	ABC transporter signature motif; other site
661410004185	Walker B; other site
661410004186	D-loop; other site
661410004187	H-loop/switch region; other site
661410004188	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
661410004189	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
661410004190	TM-ABC transporter signature motif; other site
661410004191	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
661410004192	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
661410004193	TM-ABC transporter signature motif; other site
661410004194	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
661410004195	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
661410004196	putative ligand binding site [chemical binding]; other site
661410004197	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
661410004198	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
661410004199	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
661410004200	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
661410004201	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
661410004202	catalytic loop [active]
661410004203	iron binding site [ion binding]; other site
661410004204	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
661410004205	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
661410004206	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
661410004207	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
661410004208	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
661410004209	allantoate amidohydrolase; Reviewed; Region: PRK09290
661410004210	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
661410004211	active site
661410004212	metal binding site [ion binding]; metal-binding site
661410004213	dimer interface [polypeptide binding]; other site
661410004214	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
661410004215	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
661410004216	inhibitor-cofactor binding pocket; inhibition site
661410004217	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410004218	catalytic residue [active]
661410004219	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
661410004220	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
661410004221	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
661410004222	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
661410004223	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
661410004224	ATP binding site [chemical binding]; other site
661410004225	putative Mg++ binding site [ion binding]; other site
661410004226	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
661410004227	nucleotide binding region [chemical binding]; other site
661410004228	ATP-binding site [chemical binding]; other site
661410004229	TRCF domain; Region: TRCF; pfam03461
661410004230	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
661410004231	urea transporter, Yersinia type; Region: urea_trans_yut; TIGR03441
661410004232	UreD urease accessory protein; Region: UreD; pfam01774
661410004233	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
661410004234	G1 box; other site
661410004235	GTP/Mg2+ binding site [chemical binding]; other site
661410004236	G2 box; other site
661410004237	Switch I region; other site
661410004238	Switch II region; other site
661410004239	G4 box; other site
661410004240	G5 box; other site
661410004241	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
661410004242	UreF; Region: UreF; pfam01730
661410004243	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
661410004244	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
661410004245	dimer interface [polypeptide binding]; other site
661410004246	catalytic residues [active]
661410004247	camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636
661410004248	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
661410004249	urease subunit alpha; Reviewed; Region: ureC; PRK13207
661410004250	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
661410004251	subunit interactions [polypeptide binding]; other site
661410004252	active site
661410004253	flap region; other site
661410004254	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
661410004255	alpha-beta subunit interface [polypeptide binding]; other site
661410004256	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
661410004257	alpha-gamma subunit interface [polypeptide binding]; other site
661410004258	beta-gamma subunit interface [polypeptide binding]; other site
661410004259	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
661410004260	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
661410004261	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
661410004262	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
661410004263	multiple promoter invertase; Provisional; Region: mpi; PRK13413
661410004264	catalytic residues [active]
661410004265	catalytic nucleophile [active]
661410004266	Presynaptic Site I dimer interface [polypeptide binding]; other site
661410004267	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
661410004268	Synaptic Flat tetramer interface [polypeptide binding]; other site
661410004269	Synaptic Site I dimer interface [polypeptide binding]; other site
661410004270	DNA binding site [nucleotide binding]
661410004271	Homeodomain-like domain; Region: HTH_23; pfam13384
661410004272	Y-family of DNA polymerases; Region: PolY; cl12025
661410004273	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
661410004274	Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453
661410004275	active site
661410004276	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
661410004277	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
661410004278	polymerase nucleotide-binding site; other site
661410004279	DNA-binding residues [nucleotide binding]; DNA binding site
661410004280	nucleotide binding site [chemical binding]; other site
661410004281	primase nucleotide-binding site [nucleotide binding]; other site
661410004282	D5 N terminal like; Region: D5_N; smart00885
661410004283	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
661410004284	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
661410004285	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
661410004286	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
661410004287	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
661410004288	Protein of unknown function DUF72; Region: DUF72; pfam01904
661410004289	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
661410004290	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
661410004291	catalytic core [active]
661410004292	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
661410004293	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
661410004294	Zn2+ binding site [ion binding]; other site
661410004295	Mg2+ binding site [ion binding]; other site
661410004296	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
661410004297	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
661410004298	conserved cys residue [active]
661410004299	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
661410004300	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
661410004301	beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753
661410004302	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410004303	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410004304	ATP binding site [chemical binding]; other site
661410004305	Mg2+ binding site [ion binding]; other site
661410004306	G-X-G motif; other site
661410004307	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
661410004308	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
661410004309	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
661410004310	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
661410004311	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
661410004312	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
661410004313	DNA binding residues [nucleotide binding]
661410004314	dimerization interface [polypeptide binding]; other site
661410004315	HTH-like domain; Region: HTH_21; pfam13276
661410004316	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
661410004317	Integrase core domain; Region: rve; pfam00665
661410004318	Integrase core domain; Region: rve_3; pfam13683
661410004319	Transposase; Region: HTH_Tnp_1; cl17663
661410004320	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
661410004321	Sel1-like repeats; Region: SEL1; smart00671
661410004322	Sel1-like repeats; Region: SEL1; smart00671
661410004323	Sel1-like repeats; Region: SEL1; smart00671
661410004324	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
661410004325	iron-sulfur cluster [ion binding]; other site
661410004326	[2Fe-2S] cluster binding site [ion binding]; other site
661410004327	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
661410004328	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
661410004329	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
661410004330	Walker A/P-loop; other site
661410004331	ATP binding site [chemical binding]; other site
661410004332	Q-loop/lid; other site
661410004333	ABC transporter signature motif; other site
661410004334	Walker B; other site
661410004335	D-loop; other site
661410004336	H-loop/switch region; other site
661410004337	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
661410004338	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
661410004339	Walker A/P-loop; other site
661410004340	ATP binding site [chemical binding]; other site
661410004341	Q-loop/lid; other site
661410004342	ABC transporter signature motif; other site
661410004343	Walker B; other site
661410004344	D-loop; other site
661410004345	H-loop/switch region; other site
661410004346	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
661410004347	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
661410004348	TM-ABC transporter signature motif; other site
661410004349	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
661410004350	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
661410004351	TM-ABC transporter signature motif; other site
661410004352	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
661410004353	Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331
661410004354	ligand binding site [chemical binding]; other site
661410004355	Integrase core domain; Region: rve_3; pfam13683
661410004356	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
661410004357	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
661410004358	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
661410004359	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
661410004360	catalytic site [active]
661410004361	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
661410004362	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
661410004363	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
661410004364	short chain dehydrogenase; Provisional; Region: PRK06179
661410004365	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
661410004366	NADP binding site [chemical binding]; other site
661410004367	active site
661410004368	steroid binding site; other site
661410004369	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
661410004370	catalytic core [active]
661410004371	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
661410004372	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
661410004373	classical (c) SDRs; Region: SDR_c; cd05233
661410004374	NAD(P) binding site [chemical binding]; other site
661410004375	active site
661410004376	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
661410004377	PAS fold; Region: PAS_4; pfam08448
661410004378	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410004379	putative active site [active]
661410004380	heme pocket [chemical binding]; other site
661410004381	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410004382	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410004383	dimer interface [polypeptide binding]; other site
661410004384	phosphorylation site [posttranslational modification]
661410004385	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410004386	ATP binding site [chemical binding]; other site
661410004387	Mg2+ binding site [ion binding]; other site
661410004388	G-X-G motif; other site
661410004389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410004390	Response regulator receiver domain; Region: Response_reg; pfam00072
661410004391	active site
661410004392	phosphorylation site [posttranslational modification]
661410004393	intermolecular recognition site; other site
661410004394	dimerization interface [polypeptide binding]; other site
661410004395	PAS domain S-box; Region: sensory_box; TIGR00229
661410004396	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410004397	putative active site [active]
661410004398	heme pocket [chemical binding]; other site
661410004399	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410004400	GAF domain; Region: GAF; pfam01590
661410004401	GAF domain; Region: GAF; pfam01590
661410004402	Cytochrome P450; Region: p450; cl12078
661410004403	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
661410004404	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410004405	PAS domain; Region: PAS_9; pfam13426
661410004406	putative active site [active]
661410004407	heme pocket [chemical binding]; other site
661410004408	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410004409	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410004410	metal binding site [ion binding]; metal-binding site
661410004411	active site
661410004412	I-site; other site
661410004413	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410004414	Protein of unknown function (DUF1194); Region: DUF1194; pfam06707
661410004415	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
661410004416	ApbE family; Region: ApbE; pfam02424
661410004417	FMN-binding domain; Region: FMN_bind; cl01081
661410004418	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
661410004419	4Fe-4S binding domain; Region: Fer4_5; pfam12801
661410004420	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
661410004421	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
661410004422	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
661410004423	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
661410004424	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
661410004425	ligand binding site [chemical binding]; other site
661410004426	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
661410004427	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
661410004428	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
661410004429	substrate binding pocket [chemical binding]; other site
661410004430	membrane-bound complex binding site; other site
661410004431	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
661410004432	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
661410004433	dimer interface [polypeptide binding]; other site
661410004434	Trp docking motif [polypeptide binding]; other site
661410004435	active site
661410004436	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410004437	Major Facilitator Superfamily; Region: MFS_1; pfam07690
661410004438	putative substrate translocation pore; other site
661410004439	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410004440	Protein of unknown function (DUF938); Region: DUF938; pfam06080
661410004441	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
661410004442	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
661410004443	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
661410004444	short chain dehydrogenase; Provisional; Region: PRK06172
661410004445	classical (c) SDRs; Region: SDR_c; cd05233
661410004446	NAD(P) binding site [chemical binding]; other site
661410004447	active site
661410004448	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410004449	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410004450	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
661410004451	dimerization interface [polypeptide binding]; other site
661410004452	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
661410004453	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410004454	Ligand Binding Site [chemical binding]; other site
661410004455	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
661410004456	Cytochrome c; Region: Cytochrom_C; pfam00034
661410004457	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410004458	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410004459	ligand binding site [chemical binding]; other site
661410004460	flexible hinge region; other site
661410004461	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
661410004462	putative switch regulator; other site
661410004463	non-specific DNA interactions [nucleotide binding]; other site
661410004464	DNA binding site [nucleotide binding]
661410004465	sequence specific DNA binding site [nucleotide binding]; other site
661410004466	putative cAMP binding site [chemical binding]; other site
661410004467	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
661410004468	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
661410004469	Walker A/P-loop; other site
661410004470	ATP binding site [chemical binding]; other site
661410004471	Q-loop/lid; other site
661410004472	ABC transporter signature motif; other site
661410004473	Walker B; other site
661410004474	D-loop; other site
661410004475	H-loop/switch region; other site
661410004476	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
661410004477	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410004478	Walker A/P-loop; other site
661410004479	ATP binding site [chemical binding]; other site
661410004480	Q-loop/lid; other site
661410004481	ABC transporter signature motif; other site
661410004482	D-loop; other site
661410004483	H-loop/switch region; other site
661410004484	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
661410004485	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
661410004486	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
661410004487	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
661410004488	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
661410004489	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
661410004490	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
661410004491	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
661410004492	Amidase; Region: Amidase; cl11426
661410004493	Response regulator receiver domain; Region: Response_reg; pfam00072
661410004494	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410004495	active site
661410004496	phosphorylation site [posttranslational modification]
661410004497	intermolecular recognition site; other site
661410004498	dimerization interface [polypeptide binding]; other site
661410004499	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
661410004500	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
661410004501	DXD motif; other site
661410004502	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
661410004503	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
661410004504	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
661410004505	TPR motif; other site
661410004506	TPR repeat; Region: TPR_11; pfam13414
661410004507	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410004508	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
661410004509	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
661410004510	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410004511	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
661410004512	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
661410004513	Putative zinc-finger; Region: zf-HC2; pfam13490
661410004514	RNA polymerase sigma factor; Provisional; Region: PRK12511
661410004515	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
661410004516	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
661410004517	DNA binding residues [nucleotide binding]
661410004518	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
661410004519	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
661410004520	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410004521	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
661410004522	Protein of unknown function (DUF461); Region: DUF461; pfam04314
661410004523	Protein of unknown function (DUF461); Region: DUF461; pfam04314
661410004524	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
661410004525	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
661410004526	Cu(I) binding site [ion binding]; other site
661410004527	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
661410004528	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
661410004529	N-terminal plug; other site
661410004530	ligand-binding site [chemical binding]; other site
661410004531	Caspase domain; Region: Peptidase_C14; pfam00656
661410004532	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
661410004533	Transcriptional regulators [Transcription]; Region: GntR; COG1802
661410004534	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
661410004535	DNA-binding site [nucleotide binding]; DNA binding site
661410004536	FCD domain; Region: FCD; pfam07729
661410004537	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
661410004538	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
661410004539	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
661410004540	DctM-like transporters; Region: DctM; pfam06808
661410004541	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
661410004542	similar to hypothetical protein; Evidence 6 : Doubtful CDS
661410004543	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
661410004544	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
661410004545	dimer interface [polypeptide binding]; other site
661410004546	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410004547	catalytic residue [active]
661410004548	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
661410004549	Protein of unknown function, DUF606; Region: DUF606; pfam04657
661410004550	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
661410004551	MG2 domain; Region: A2M_N; pfam01835
661410004552	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
661410004553	surface patch; other site
661410004554	thioester region; other site
661410004555	specificity defining residues; other site
661410004556	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
661410004557	Transglycosylase; Region: Transgly; pfam00912
661410004558	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
661410004559	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
661410004560	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
661410004561	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410004562	non-specific DNA binding site [nucleotide binding]; other site
661410004563	salt bridge; other site
661410004564	sequence-specific DNA binding site [nucleotide binding]; other site
661410004565	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
661410004566	active site
661410004567	catalytic site [active]
661410004568	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
661410004569	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
661410004570	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
661410004571	metal ion-dependent adhesion site (MIDAS); other site
661410004572	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
661410004573	catalytic core [active]
661410004574	High-affinity nickel-transport protein; Region: NicO; cl00964
661410004575	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
661410004576	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
661410004577	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
661410004578	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
661410004579	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
661410004580	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
661410004581	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
661410004582	TPR motif; other site
661410004583	binding surface
661410004584	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
661410004585	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410004586	ATP binding site [chemical binding]; other site
661410004587	Mg2+ binding site [ion binding]; other site
661410004588	G-X-G motif; other site
661410004589	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
661410004590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410004591	active site
661410004592	phosphorylation site [posttranslational modification]
661410004593	intermolecular recognition site; other site
661410004594	dimerization interface [polypeptide binding]; other site
661410004595	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410004596	DNA binding site [nucleotide binding]
661410004597	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
661410004598	catalytic residue [active]
661410004599	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
661410004600	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
661410004601	Putative phage tail protein; Region: Phage-tail_3; pfam13550
661410004602	NlpC/P60 family; Region: NLPC_P60; cl17555
661410004603	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
661410004604	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
661410004605	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
661410004606	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
661410004607	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
661410004608	Phage-related minor tail protein [Function unknown]; Region: COG5281
661410004609	Conserved hypothetical phage protein (DUF2376); Region: DUF2376; cl09774
661410004610	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
661410004611	Phage major tail protein 2; Region: Phage_tail_2; cl11463
661410004612	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
661410004613	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
661410004614	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
661410004615	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
661410004616	cleavage site
661410004617	active site
661410004618	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
661410004619	active site
661410004620	substrate binding sites [chemical binding]; other site
661410004621	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
661410004622	Phage capsid family; Region: Phage_capsid; pfam05065
661410004623	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
661410004624	Phage-related protein [Function unknown]; Region: COG4695
661410004625	Phage portal protein; Region: Phage_portal; pfam04860
661410004626	Uncharacterized conserved protein [Function unknown]; Region: COG5323
661410004627	Terminase-like family; Region: Terminase_6; pfam03237
661410004628	similar to hypothetical protein; Evidence 6 : Doubtful CDS
661410004629	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
661410004630	active site
661410004631	SAM binding site [chemical binding]; other site
661410004632	homodimer interface [polypeptide binding]; other site
661410004633	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
661410004634	active site
661410004635	SAM binding site [chemical binding]; other site
661410004636	homodimer interface [polypeptide binding]; other site
661410004637	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
661410004638	Precorrin-8X methylmutase; Region: CbiC; pfam02570
661410004639	precorrin-3B synthase; Region: CobG; TIGR02435
661410004640	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
661410004641	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
661410004642	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
661410004643	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
661410004644	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
661410004645	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
661410004646	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
661410004647	Protein of unknown function (DUF1636); Region: DUF1636; pfam07845
661410004648	cobalt transporter subunit CbtA (proposed); Region: CbtA; TIGR02458
661410004649	Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489
661410004650	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
661410004651	MarR family; Region: MarR_2; pfam12802
661410004652	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
661410004653	homotrimer interface [polypeptide binding]; other site
661410004654	Walker A motif; other site
661410004655	GTP binding site [chemical binding]; other site
661410004656	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
661410004657	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
661410004658	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
661410004659	homodimer interface [polypeptide binding]; other site
661410004660	Walker A motif; other site
661410004661	ATP binding site [chemical binding]; other site
661410004662	hydroxycobalamin binding site [chemical binding]; other site
661410004663	Walker B motif; other site
661410004664	fumarate hydratase; Reviewed; Region: fumC; PRK00485
661410004665	Class II fumarases; Region: Fumarase_classII; cd01362
661410004666	active site
661410004667	tetramer interface [polypeptide binding]; other site
661410004668	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
661410004669	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
661410004670	HAMP domain; Region: HAMP; pfam00672
661410004671	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410004672	dimer interface [polypeptide binding]; other site
661410004673	putative CheW interface [polypeptide binding]; other site
661410004674	PAS fold; Region: PAS_4; pfam08448
661410004675	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
661410004676	PAS fold; Region: PAS_3; pfam08447
661410004677	putative active site [active]
661410004678	heme pocket [chemical binding]; other site
661410004679	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410004680	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
661410004681	putative active site [active]
661410004682	heme pocket [chemical binding]; other site
661410004683	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410004684	putative active site [active]
661410004685	heme pocket [chemical binding]; other site
661410004686	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410004687	dimer interface [polypeptide binding]; other site
661410004688	phosphorylation site [posttranslational modification]
661410004689	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
661410004690	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410004691	ATP binding site [chemical binding]; other site
661410004692	Mg2+ binding site [ion binding]; other site
661410004693	G-X-G motif; other site
661410004694	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410004695	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410004696	active site
661410004697	phosphorylation site [posttranslational modification]
661410004698	intermolecular recognition site; other site
661410004699	dimerization interface [polypeptide binding]; other site
661410004700	EamA-like transporter family; Region: EamA; pfam00892
661410004701	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
661410004702	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
661410004703	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
661410004704	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
661410004705	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
661410004706	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
661410004707	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
661410004708	Protein of unknown function DUF58; Region: DUF58; pfam01882
661410004709	MoxR-like ATPases [General function prediction only]; Region: COG0714
661410004710	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
661410004711	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
661410004712	CoenzymeA binding site [chemical binding]; other site
661410004713	subunit interaction site [polypeptide binding]; other site
661410004714	PHB binding site; other site
661410004715	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
661410004716	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
661410004717	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
661410004718	putative active site [active]
661410004719	putative CoA binding site [chemical binding]; other site
661410004720	nudix motif; other site
661410004721	metal binding site [ion binding]; metal-binding site
661410004722	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
661410004723	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
661410004724	active site
661410004725	NTP binding site [chemical binding]; other site
661410004726	metal binding triad [ion binding]; metal-binding site
661410004727	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
661410004728	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14736
661410004729	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
661410004730	gamma subunit interface [polypeptide binding]; other site
661410004731	epsilon subunit interface [polypeptide binding]; other site
661410004732	LBP interface [polypeptide binding]; other site
661410004733	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
661410004734	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
661410004735	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
661410004736	alpha subunit interaction interface [polypeptide binding]; other site
661410004737	Walker A motif; other site
661410004738	ATP binding site [chemical binding]; other site
661410004739	Walker B motif; other site
661410004740	inhibitor binding site; inhibition site
661410004741	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
661410004742	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
661410004743	core domain interface [polypeptide binding]; other site
661410004744	delta subunit interface [polypeptide binding]; other site
661410004745	epsilon subunit interface [polypeptide binding]; other site
661410004746	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
661410004747	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
661410004748	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
661410004749	beta subunit interaction interface [polypeptide binding]; other site
661410004750	Walker A motif; other site
661410004751	ATP binding site [chemical binding]; other site
661410004752	Walker B motif; other site
661410004753	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
661410004754	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
661410004755	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
661410004756	ferrochelatase; Reviewed; Region: hemH; PRK00035
661410004757	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
661410004758	C-terminal domain interface [polypeptide binding]; other site
661410004759	active site
661410004760	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
661410004761	active site
661410004762	N-terminal domain interface [polypeptide binding]; other site
661410004763	Methyltransferase domain; Region: Methyltransf_23; pfam13489
661410004764	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410004765	S-adenosylmethionine binding site [chemical binding]; other site
661410004766	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
661410004767	active site
661410004768	metal binding site [ion binding]; metal-binding site
661410004769	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
661410004770	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
661410004771	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
661410004772	ligand binding site [chemical binding]; other site
661410004773	active site
661410004774	UGI interface [polypeptide binding]; other site
661410004775	catalytic site [active]
661410004776	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
661410004777	active site residue [active]
661410004778	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
661410004779	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
661410004780	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
661410004781	Chromate transporter; Region: Chromate_transp; pfam02417
661410004782	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
661410004783	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
661410004784	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
661410004785	ATP binding site [chemical binding]; other site
661410004786	putative Mg++ binding site [ion binding]; other site
661410004787	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
661410004788	SEC-C motif; Region: SEC-C; pfam02810
661410004789	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
661410004790	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
661410004791	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
661410004792	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
661410004793	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
661410004794	nudix motif; other site
661410004795	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
661410004796	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
661410004797	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
661410004798	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
661410004799	active site
661410004800	catalytic site [active]
661410004801	substrate binding site [chemical binding]; other site
661410004802	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
661410004803	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
661410004804	CoA-binding site [chemical binding]; other site
661410004805	ATP-binding [chemical binding]; other site
661410004806	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
661410004807	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
661410004808	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
661410004809	NAD(P) binding site [chemical binding]; other site
661410004810	shikimate binding site; other site
661410004811	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
661410004812	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
661410004813	putative active site [active]
661410004814	Protein of unknown function (DUF563); Region: DUF563; pfam04577
661410004815	PEP synthetase regulatory protein; Provisional; Region: PRK05339
661410004816	uroporphyrinogen decarboxylase; Validated; Region: hemE; PRK00115
661410004817	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
661410004818	nudix motif; other site
661410004819	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
661410004820	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
661410004821	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
661410004822	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
661410004823	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
661410004824	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
661410004825	motif 1; other site
661410004826	dimer interface [polypeptide binding]; other site
661410004827	active site
661410004828	motif 2; other site
661410004829	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
661410004830	active site
661410004831	motif 3; other site
661410004832	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
661410004833	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
661410004834	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
661410004835	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
661410004836	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410004837	putative substrate translocation pore; other site
661410004838	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
661410004839	putative acyl-acceptor binding pocket; other site
661410004840	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
661410004841	acyl-activating enzyme (AAE) consensus motif; other site
661410004842	AMP binding site [chemical binding]; other site
661410004843	active site
661410004844	CoA binding site [chemical binding]; other site
661410004845	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
661410004846	Predicted transcriptional regulator [Transcription]; Region: COG2944
661410004847	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410004848	non-specific DNA binding site [nucleotide binding]; other site
661410004849	salt bridge; other site
661410004850	sequence-specific DNA binding site [nucleotide binding]; other site
661410004851	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
661410004852	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
661410004853	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
661410004854	diiron binding motif [ion binding]; other site
661410004855	Uncharacterized conserved protein [Function unknown]; Region: COG1633
661410004856	CCC1-related protein family; Region: CCC1_like_1; cd02437
661410004857	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
661410004858	trimer interface [polypeptide binding]; other site
661410004859	putative metal binding site [ion binding]; other site
661410004860	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
661410004861	trimer interface [polypeptide binding]; other site
661410004862	putative metal binding site [ion binding]; other site
661410004863	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
661410004864	MoaE homodimer interface [polypeptide binding]; other site
661410004865	MoaD interaction [polypeptide binding]; other site
661410004866	active site residues [active]
661410004867	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
661410004868	malate:quinone oxidoreductase; Validated; Region: PRK05257
661410004869	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
661410004870	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
661410004871	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
661410004872	metal ion-dependent adhesion site (MIDAS); other site
661410004873	MoxR-like ATPases [General function prediction only]; Region: COG0714
661410004874	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
661410004875	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854
661410004876	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
661410004877	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
661410004878	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
661410004879	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
661410004880	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
661410004881	putative uracil binding site [chemical binding]; other site
661410004882	putative active site [active]
661410004883	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
661410004884	active site
661410004885	dimer interface [polypeptide binding]; other site
661410004886	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
661410004887	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
661410004888	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
661410004889	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
661410004890	trimer interface [polypeptide binding]; other site
661410004891	active site
661410004892	Protein of unknown function (DUF429); Region: DUF429; cl12046
661410004893	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
661410004894	nudix motif; other site
661410004895	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
661410004896	active site clefts [active]
661410004897	zinc binding site [ion binding]; other site
661410004898	dimer interface [polypeptide binding]; other site
661410004899	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
661410004900	active site
661410004901	Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090
661410004902	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
661410004903	putative binding surface; other site
661410004904	active site
661410004905	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
661410004906	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
661410004907	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410004908	ATP binding site [chemical binding]; other site
661410004909	Mg2+ binding site [ion binding]; other site
661410004910	G-X-G motif; other site
661410004911	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
661410004912	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410004913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410004914	active site
661410004915	phosphorylation site [posttranslational modification]
661410004916	intermolecular recognition site; other site
661410004917	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
661410004918	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410004919	Response regulator receiver domain; Region: Response_reg; pfam00072
661410004920	active site
661410004921	phosphorylation site [posttranslational modification]
661410004922	intermolecular recognition site; other site
661410004923	dimerization interface [polypeptide binding]; other site
661410004924	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
661410004925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410004926	active site
661410004927	phosphorylation site [posttranslational modification]
661410004928	intermolecular recognition site; other site
661410004929	dimerization interface [polypeptide binding]; other site
661410004930	CheB methylesterase; Region: CheB_methylest; pfam01339
661410004931	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
661410004932	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
661410004933	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
661410004934	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
661410004935	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
661410004936	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
661410004937	UV-endonuclease UvdE; Region: UvdE; cl10036
661410004938	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
661410004939	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
661410004940	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
661410004941	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
661410004942	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
661410004943	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
661410004944	Ligand binding site [chemical binding]; other site
661410004945	Electron transfer flavoprotein domain; Region: ETF; pfam01012
661410004946	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
661410004947	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
661410004948	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
661410004949	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
661410004950	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
661410004951	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
661410004952	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
661410004953	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
661410004954	NAD(P) binding site [chemical binding]; other site
661410004955	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
661410004956	active site
661410004957	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
661410004958	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
661410004959	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
661410004960	active site
661410004961	catalytic site [active]
661410004962	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
661410004963	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
661410004964	active site
661410004965	homotetramer interface [polypeptide binding]; other site
661410004966	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
661410004967	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
661410004968	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
661410004969	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
661410004970	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
661410004971	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
661410004972	dimer interface [polypeptide binding]; other site
661410004973	motif 1; other site
661410004974	active site
661410004975	motif 2; other site
661410004976	motif 3; other site
661410004977	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
661410004978	anticodon binding site; other site
661410004979	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
661410004980	dimer interface [polypeptide binding]; other site
661410004981	putative tRNA-binding site [nucleotide binding]; other site
661410004982	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
661410004983	Major Facilitator Superfamily; Region: MFS_1; pfam07690
661410004984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410004985	preprotein translocase subunit SecB; Validated; Region: PRK05751
661410004986	SecA binding site; other site
661410004987	Preprotein binding site; other site
661410004988	Tim44-like domain; Region: Tim44; pfam04280
661410004989	MltA specific insert domain; Region: MltA; smart00925
661410004990	3D domain; Region: 3D; pfam06725
661410004991	Smr domain; Region: Smr; pfam01713
661410004992	transcription termination factor Rho; Provisional; Region: rho; PRK09376
661410004993	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
661410004994	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
661410004995	RNA binding site [nucleotide binding]; other site
661410004996	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
661410004997	multimer interface [polypeptide binding]; other site
661410004998	Walker A motif; other site
661410004999	ATP binding site [chemical binding]; other site
661410005000	Walker B motif; other site
661410005001	pyruvate dehydrogenase; Provisional; Region: PRK09124
661410005002	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
661410005003	PYR/PP interface [polypeptide binding]; other site
661410005004	dimer interface [polypeptide binding]; other site
661410005005	tetramer interface [polypeptide binding]; other site
661410005006	TPP binding site [chemical binding]; other site
661410005007	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
661410005008	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
661410005009	TPP-binding site [chemical binding]; other site
661410005010	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
661410005011	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
661410005012	putative lipid kinase; Reviewed; Region: PRK13057
661410005013	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
661410005014	active site
661410005015	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
661410005016	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
661410005017	Predicted transcriptional regulator [Transcription]; Region: COG2944
661410005018	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410005019	non-specific DNA binding site [nucleotide binding]; other site
661410005020	salt bridge; other site
661410005021	sequence-specific DNA binding site [nucleotide binding]; other site
661410005022	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
661410005023	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
661410005024	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
661410005025	trimer interface [polypeptide binding]; other site
661410005026	active site
661410005027	substrate binding site [chemical binding]; other site
661410005028	CoA binding site [chemical binding]; other site
661410005029	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410005030	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410005031	ligand binding site [chemical binding]; other site
661410005032	flexible hinge region; other site
661410005033	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
661410005034	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410005035	active site
661410005036	phosphorylation site [posttranslational modification]
661410005037	intermolecular recognition site; other site
661410005038	dimerization interface [polypeptide binding]; other site
661410005039	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410005040	DNA binding site [nucleotide binding]
661410005041	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
661410005042	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
661410005043	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
661410005044	catalytic residue [active]
661410005045	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
661410005046	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
661410005047	HIGH motif; other site
661410005048	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
661410005049	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
661410005050	active site
661410005051	KMSKS motif; other site
661410005052	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
661410005053	tRNA binding surface [nucleotide binding]; other site
661410005054	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
661410005055	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
661410005056	trmE is a tRNA modification GTPase; Region: trmE; cd04164
661410005057	G1 box; other site
661410005058	GTP/Mg2+ binding site [chemical binding]; other site
661410005059	Switch I region; other site
661410005060	G2 box; other site
661410005061	Switch II region; other site
661410005062	G3 box; other site
661410005063	G4 box; other site
661410005064	G5 box; other site
661410005065	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
661410005066	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
661410005067	PAS fold; Region: PAS_3; pfam08447
661410005068	putative active site [active]
661410005069	heme pocket [chemical binding]; other site
661410005070	PAS fold; Region: PAS_3; pfam08447
661410005071	Helix-turn-helix; Region: HTH_3; pfam01381
661410005072	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
661410005073	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
661410005074	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
661410005075	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
661410005076	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
661410005077	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
661410005078	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
661410005079	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
661410005080	P-loop; other site
661410005081	Magnesium ion binding site [ion binding]; other site
661410005082	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
661410005083	Magnesium ion binding site [ion binding]; other site
661410005084	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
661410005085	ParB-like nuclease domain; Region: ParB; smart00470
661410005086	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
661410005087	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
661410005088	Lipopolysaccharide-assembly; Region: LptE; cl01125
661410005089	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
661410005090	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
661410005091	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
661410005092	prephenate dehydrogenase; Validated; Region: PRK08507
661410005093	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
661410005094	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
661410005095	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410005096	homodimer interface [polypeptide binding]; other site
661410005097	catalytic residue [active]
661410005098	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
661410005099	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
661410005100	N-terminal plug; other site
661410005101	ligand-binding site [chemical binding]; other site
661410005102	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
661410005103	potassium uptake protein; Region: kup; TIGR00794
661410005104	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
661410005105	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
661410005106	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
661410005107	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
661410005108	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
661410005109	active site
661410005110	nucleophile elbow; other site
661410005111	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
661410005112	putative DNA binding site [nucleotide binding]; other site
661410005113	putative Zn2+ binding site [ion binding]; other site
661410005114	Methyltransferase domain; Region: Methyltransf_31; pfam13847
661410005115	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410005116	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
661410005117	FAD binding site [chemical binding]; other site
661410005118	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
661410005119	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
661410005120	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
661410005121	substrate binding pocket [chemical binding]; other site
661410005122	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
661410005123	B12 binding site [chemical binding]; other site
661410005124	cobalt ligand [ion binding]; other site
661410005125	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
661410005126	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
661410005127	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
661410005128	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
661410005129	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
661410005130	Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968
661410005131	putative active site [active]
661410005132	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
661410005133	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
661410005134	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
661410005135	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
661410005136	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
661410005137	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
661410005138	ThiC-associated domain; Region: ThiC-associated; pfam13667
661410005139	ThiC family; Region: ThiC; pfam01964
661410005140	FlaG protein; Region: FlaG; cl00591
661410005141	Flagellar protein FlaF; Region: FlaF; cl11454
661410005142	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
661410005143	putative active site [active]
661410005144	putative metal binding site [ion binding]; other site
661410005145	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
661410005146	TolR protein; Region: tolR; TIGR02801
661410005147	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
661410005148	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
661410005149	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
661410005150	putative dimer interface [polypeptide binding]; other site
661410005151	Uncharacterized small protein [Function unknown]; Region: COG5568
661410005152	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
661410005153	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
661410005154	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
661410005155	putative ADP-binding pocket [chemical binding]; other site
661410005156	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410005157	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
661410005158	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
661410005159	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
661410005160	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
661410005161	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
661410005162	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410005163	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
661410005164	putative ADP-binding pocket [chemical binding]; other site
661410005165	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
661410005166	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
661410005167	23S rRNA binding site [nucleotide binding]; other site
661410005168	L21 binding site [polypeptide binding]; other site
661410005169	L13 binding site [polypeptide binding]; other site
661410005170	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
661410005171	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
661410005172	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
661410005173	dimer interface [polypeptide binding]; other site
661410005174	motif 1; other site
661410005175	active site
661410005176	motif 2; other site
661410005177	motif 3; other site
661410005178	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
661410005179	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
661410005180	putative tRNA-binding site [nucleotide binding]; other site
661410005181	B3/4 domain; Region: B3_4; pfam03483
661410005182	tRNA synthetase B5 domain; Region: B5; smart00874
661410005183	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
661410005184	dimer interface [polypeptide binding]; other site
661410005185	motif 1; other site
661410005186	motif 3; other site
661410005187	motif 2; other site
661410005188	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
661410005189	Protein of unknown function (DUF1186); Region: DUF1186; pfam06685
661410005190	SEC-C motif; Region: SEC-C; pfam02810
661410005191	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
661410005192	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
661410005193	ATP binding site [chemical binding]; other site
661410005194	substrate interface [chemical binding]; other site
661410005195	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
661410005196	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
661410005197	metal binding site [ion binding]; metal-binding site
661410005198	dimer interface [polypeptide binding]; other site
661410005199	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
661410005200	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
661410005201	dimerization interface 3.5A [polypeptide binding]; other site
661410005202	active site
661410005203	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
661410005204	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
661410005205	putative active site [active]
661410005206	substrate binding site [chemical binding]; other site
661410005207	putative cosubstrate binding site; other site
661410005208	catalytic site [active]
661410005209	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
661410005210	substrate binding site [chemical binding]; other site
661410005211	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
661410005212	active site
661410005213	catalytic residues [active]
661410005214	metal binding site [ion binding]; metal-binding site
661410005215	recombination protein RecR; Reviewed; Region: recR; PRK00076
661410005216	RecR protein; Region: RecR; pfam02132
661410005217	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
661410005218	putative active site [active]
661410005219	putative metal-binding site [ion binding]; other site
661410005220	tetramer interface [polypeptide binding]; other site
661410005221	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
661410005222	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
661410005223	active site
661410005224	substrate-binding site [chemical binding]; other site
661410005225	metal-binding site [ion binding]
661410005226	ATP binding site [chemical binding]; other site
661410005227	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
661410005228	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410005229	FeS/SAM binding site; other site
661410005230	shikimate kinase; Provisional; Region: PRK13946
661410005231	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
661410005232	ADP binding site [chemical binding]; other site
661410005233	magnesium binding site [ion binding]; other site
661410005234	putative shikimate binding site; other site
661410005235	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
661410005236	active site
661410005237	dimer interface [polypeptide binding]; other site
661410005238	metal binding site [ion binding]; metal-binding site
661410005239	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
661410005240	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
661410005241	malate dehydrogenase; Reviewed; Region: PRK06223
661410005242	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
661410005243	NAD(P) binding site [chemical binding]; other site
661410005244	dimer interface [polypeptide binding]; other site
661410005245	tetramer (dimer of dimers) interface [polypeptide binding]; other site
661410005246	substrate binding site [chemical binding]; other site
661410005247	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
661410005248	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
661410005249	CoA-ligase; Region: Ligase_CoA; pfam00549
661410005250	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
661410005251	CoA binding domain; Region: CoA_binding; smart00881
661410005252	CoA-ligase; Region: Ligase_CoA; pfam00549
661410005253	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
661410005254	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
661410005255	TPP-binding site [chemical binding]; other site
661410005256	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
661410005257	dimer interface [polypeptide binding]; other site
661410005258	PYR/PP interface [polypeptide binding]; other site
661410005259	TPP binding site [chemical binding]; other site
661410005260	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
661410005261	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
661410005262	E3 interaction surface; other site
661410005263	lipoyl attachment site [posttranslational modification]; other site
661410005264	e3 binding domain; Region: E3_binding; pfam02817
661410005265	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
661410005266	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
661410005267	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
661410005268	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
661410005269	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
661410005270	histidine kinase; Provisional; Region: PRK13557
661410005271	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410005272	putative active site [active]
661410005273	heme pocket [chemical binding]; other site
661410005274	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410005275	dimer interface [polypeptide binding]; other site
661410005276	phosphorylation site [posttranslational modification]
661410005277	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410005278	ATP binding site [chemical binding]; other site
661410005279	Mg2+ binding site [ion binding]; other site
661410005280	G-X-G motif; other site
661410005281	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410005282	active site
661410005283	phosphorylation site [posttranslational modification]
661410005284	intermolecular recognition site; other site
661410005285	dimerization interface [polypeptide binding]; other site
661410005286	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
661410005287	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
661410005288	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
661410005289	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
661410005290	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
661410005291	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
661410005292	hydroxyglutarate oxidase; Provisional; Region: PRK11728
661410005293	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
661410005294	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
661410005295	conserved cys residue [active]
661410005296	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
661410005297	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
661410005298	putative active site [active]
661410005299	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
661410005300	domain_subunit interface; other site
661410005301	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
661410005302	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
661410005303	active site
661410005304	FMN binding site [chemical binding]; other site
661410005305	substrate binding site [chemical binding]; other site
661410005306	3Fe-4S cluster binding site [ion binding]; other site
661410005307	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
661410005308	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
661410005309	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
661410005310	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
661410005311	Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_2; cd09821
661410005312	putative heme binding site [chemical binding]; other site
661410005313	putative substrate binding site [chemical binding]; other site
661410005314	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
661410005315	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
661410005316	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
661410005317	heme binding site [chemical binding]; other site
661410005318	substrate binding site [chemical binding]; other site
661410005319	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
661410005320	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
661410005321	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
661410005322	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
661410005323	Walker A/P-loop; other site
661410005324	ATP binding site [chemical binding]; other site
661410005325	Q-loop/lid; other site
661410005326	ABC transporter signature motif; other site
661410005327	Walker B; other site
661410005328	D-loop; other site
661410005329	H-loop/switch region; other site
661410005330	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
661410005331	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
661410005332	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410005333	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410005334	Predicted transcriptional regulator [Transcription]; Region: COG2345
661410005335	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
661410005336	Histidine kinase; Region: HisKA_3; pfam07730
661410005337	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410005338	ATP binding site [chemical binding]; other site
661410005339	Mg2+ binding site [ion binding]; other site
661410005340	G-X-G motif; other site
661410005341	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
661410005342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410005343	active site
661410005344	phosphorylation site [posttranslational modification]
661410005345	intermolecular recognition site; other site
661410005346	dimerization interface [polypeptide binding]; other site
661410005347	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
661410005348	DNA binding residues [nucleotide binding]
661410005349	dimerization interface [polypeptide binding]; other site
661410005350	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
661410005351	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
661410005352	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410005353	S-adenosylmethionine binding site [chemical binding]; other site
661410005354	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
661410005355	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410005356	dimerization interface [polypeptide binding]; other site
661410005357	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410005358	dimerization interface [polypeptide binding]; other site
661410005359	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410005360	dimerization interface [polypeptide binding]; other site
661410005361	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
661410005362	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410005363	dimerization interface [polypeptide binding]; other site
661410005364	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410005365	dimerization interface [polypeptide binding]; other site
661410005366	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410005367	dimerization interface [polypeptide binding]; other site
661410005368	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410005369	dimerization interface [polypeptide binding]; other site
661410005370	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
661410005371	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410005372	dimerization interface [polypeptide binding]; other site
661410005373	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410005374	dimerization interface [polypeptide binding]; other site
661410005375	GAF domain; Region: GAF_2; pfam13185
661410005376	GAF domain; Region: GAF_3; pfam13492
661410005377	pinin/SDK/memA/ protein conserved region; Region: Pinin_SDK_memA; pfam04696
661410005378	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410005379	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410005380	dimer interface [polypeptide binding]; other site
661410005381	phosphorylation site [posttranslational modification]
661410005382	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410005383	ATP binding site [chemical binding]; other site
661410005384	Mg2+ binding site [ion binding]; other site
661410005385	G-X-G motif; other site
661410005386	Response regulator receiver domain; Region: Response_reg; pfam00072
661410005387	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410005388	active site
661410005389	phosphorylation site [posttranslational modification]
661410005390	intermolecular recognition site; other site
661410005391	dimerization interface [polypeptide binding]; other site
661410005392	Response regulator receiver domain; Region: Response_reg; pfam00072
661410005393	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410005394	active site
661410005395	phosphorylation site [posttranslational modification]
661410005396	intermolecular recognition site; other site
661410005397	dimerization interface [polypeptide binding]; other site
661410005398	Response regulator receiver domain; Region: Response_reg; pfam00072
661410005399	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410005400	active site
661410005401	phosphorylation site [posttranslational modification]
661410005402	intermolecular recognition site; other site
661410005403	dimerization interface [polypeptide binding]; other site
661410005404	Response regulator receiver domain; Region: Response_reg; pfam00072
661410005405	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410005406	active site
661410005407	phosphorylation site [posttranslational modification]
661410005408	intermolecular recognition site; other site
661410005409	dimerization interface [polypeptide binding]; other site
661410005410	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
661410005411	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410005412	putative active site [active]
661410005413	heme pocket [chemical binding]; other site
661410005414	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410005415	dimer interface [polypeptide binding]; other site
661410005416	phosphorylation site [posttranslational modification]
661410005417	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410005418	ATP binding site [chemical binding]; other site
661410005419	Mg2+ binding site [ion binding]; other site
661410005420	G-X-G motif; other site
661410005421	Response regulator receiver domain; Region: Response_reg; pfam00072
661410005422	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410005423	active site
661410005424	phosphorylation site [posttranslational modification]
661410005425	intermolecular recognition site; other site
661410005426	dimerization interface [polypeptide binding]; other site
661410005427	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
661410005428	NmrA-like family; Region: NmrA; pfam05368
661410005429	NADP binding site [chemical binding]; other site
661410005430	active site
661410005431	regulatory binding site [polypeptide binding]; other site
661410005432	LysR family transcriptional regulator; Provisional; Region: PRK14997
661410005433	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410005434	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
661410005435	putative effector binding pocket; other site
661410005436	dimerization interface [polypeptide binding]; other site
661410005437	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410005438	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410005439	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
661410005440	dimerization interface [polypeptide binding]; other site
661410005441	Isochorismatase family; Region: Isochorismatase; pfam00857
661410005442	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
661410005443	catalytic triad [active]
661410005444	dimer interface [polypeptide binding]; other site
661410005445	conserved cis-peptide bond; other site
661410005446	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
661410005447	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
661410005448	putative NAD(P) binding site [chemical binding]; other site
661410005449	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
661410005450	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410005451	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
661410005452	dimerization interface [polypeptide binding]; other site
661410005453	substrate binding pocket [chemical binding]; other site
661410005454	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
661410005455	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
661410005456	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
661410005457	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410005458	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410005459	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
661410005460	dimerization interface [polypeptide binding]; other site
661410005461	Uncharacterized conserved protein [Function unknown]; Region: COG1359
661410005462	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
661410005463	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
661410005464	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
661410005465	putative NAD(P) binding site [chemical binding]; other site
661410005466	dimer interface [polypeptide binding]; other site
661410005467	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
661410005468	EamA-like transporter family; Region: EamA; pfam00892
661410005469	EamA-like transporter family; Region: EamA; pfam00892
661410005470	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410005471	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410005472	metal binding site [ion binding]; metal-binding site
661410005473	active site
661410005474	I-site; other site
661410005475	Amidase; Region: Amidase; cl11426
661410005476	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
661410005477	HYR domain; Region: HYR; pfam02494
661410005478	HYR domain; Region: HYR; pfam02494
661410005479	HYR domain; Region: HYR; pfam02494
661410005480	xanthine permease; Region: pbuX; TIGR03173
661410005481	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
661410005482	SnoaL-like domain; Region: SnoaL_3; pfam13474
661410005483	amidase; Provisional; Region: PRK09201
661410005484	Amidase; Region: Amidase; pfam01425
661410005485	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
661410005486	Isochorismatase family; Region: Isochorismatase; pfam00857
661410005487	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
661410005488	catalytic triad [active]
661410005489	conserved cis-peptide bond; other site
661410005490	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
661410005491	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
661410005492	active site
661410005493	putative substrate binding pocket [chemical binding]; other site
661410005494	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
661410005495	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
661410005496	Walker A/P-loop; other site
661410005497	ATP binding site [chemical binding]; other site
661410005498	Q-loop/lid; other site
661410005499	ABC transporter signature motif; other site
661410005500	Walker B; other site
661410005501	D-loop; other site
661410005502	H-loop/switch region; other site
661410005503	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
661410005504	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
661410005505	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
661410005506	TM-ABC transporter signature motif; other site
661410005507	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
661410005508	TM-ABC transporter signature motif; other site
661410005509	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
661410005510	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
661410005511	putative ligand binding site [chemical binding]; other site
661410005512	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
661410005513	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
661410005514	TM-ABC transporter signature motif; other site
661410005515	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
661410005516	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
661410005517	TM-ABC transporter signature motif; other site
661410005518	formamidase; Provisional; Region: amiF; PRK13287
661410005519	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
661410005520	multimer interface [polypeptide binding]; other site
661410005521	active site
661410005522	catalytic triad [active]
661410005523	dimer interface [polypeptide binding]; other site
661410005524	Isochorismatase family; Region: Isochorismatase; pfam00857
661410005525	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
661410005526	catalytic triad [active]
661410005527	conserved cis-peptide bond; other site
661410005528	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
661410005529	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
661410005530	Walker A/P-loop; other site
661410005531	ATP binding site [chemical binding]; other site
661410005532	Q-loop/lid; other site
661410005533	ABC transporter signature motif; other site
661410005534	Walker B; other site
661410005535	D-loop; other site
661410005536	H-loop/switch region; other site
661410005537	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
661410005538	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
661410005539	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
661410005540	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
661410005541	putative ligand binding site [chemical binding]; other site
661410005542	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
661410005543	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
661410005544	Creatinine amidohydrolase; Region: Creatininase; pfam02633
661410005545	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
661410005546	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
661410005547	acyl-activating enzyme (AAE) consensus motif; other site
661410005548	AMP binding site [chemical binding]; other site
661410005549	active site
661410005550	CoA binding site [chemical binding]; other site
661410005551	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
661410005552	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
661410005553	FAD binding domain; Region: FAD_binding_4; pfam01565
661410005554	oxidase reductase; Provisional; Region: PTZ00273
661410005555	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
661410005556	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
661410005557	NMT1/THI5 like; Region: NMT1; pfam09084
661410005558	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
661410005559	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
661410005560	iron-sulfur cluster [ion binding]; other site
661410005561	[2Fe-2S] cluster binding site [ion binding]; other site
661410005562	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
661410005563	hydrophobic ligand binding site; other site
661410005564	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
661410005565	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410005566	dimer interface [polypeptide binding]; other site
661410005567	conserved gate region; other site
661410005568	putative PBP binding loops; other site
661410005569	ABC-ATPase subunit interface; other site
661410005570	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
661410005571	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
661410005572	Walker A/P-loop; other site
661410005573	ATP binding site [chemical binding]; other site
661410005574	Q-loop/lid; other site
661410005575	ABC transporter signature motif; other site
661410005576	Walker B; other site
661410005577	D-loop; other site
661410005578	H-loop/switch region; other site
661410005579	NMT1/THI5 like; Region: NMT1; pfam09084
661410005580	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410005581	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410005582	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
661410005583	dimerization interface [polypeptide binding]; other site
661410005584	cytosine deaminase-like protein; Validated; Region: PRK07583
661410005585	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
661410005586	active site
661410005587	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410005588	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410005589	LysR substrate binding domain; Region: LysR_substrate; pfam03466
661410005590	dimerization interface [polypeptide binding]; other site
661410005591	guanine deaminase; Provisional; Region: PRK09228
661410005592	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
661410005593	active site
661410005594	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
661410005595	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
661410005596	catalytic loop [active]
661410005597	iron binding site [ion binding]; other site
661410005598	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
661410005599	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
661410005600	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
661410005601	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
661410005602	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
661410005603	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
661410005604	NMT1/THI5 like; Region: NMT1; pfam09084
661410005605	substrate binding pocket [chemical binding]; other site
661410005606	membrane-bound complex binding site; other site
661410005607	hinge residues; other site
661410005608	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
661410005609	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410005610	dimer interface [polypeptide binding]; other site
661410005611	conserved gate region; other site
661410005612	putative PBP binding loops; other site
661410005613	ABC-ATPase subunit interface; other site
661410005614	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
661410005615	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
661410005616	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
661410005617	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
661410005618	Walker A/P-loop; other site
661410005619	ATP binding site [chemical binding]; other site
661410005620	Q-loop/lid; other site
661410005621	ABC transporter signature motif; other site
661410005622	Walker B; other site
661410005623	D-loop; other site
661410005624	H-loop/switch region; other site
661410005625	pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615
661410005626	pyrimidine utilization protein D; Region: RutD; TIGR03611
661410005627	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
661410005628	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
661410005629	homotrimer interaction site [polypeptide binding]; other site
661410005630	putative active site [active]
661410005631	Isochorismatase family; Region: Isochorismatase; pfam00857
661410005632	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
661410005633	catalytic triad [active]
661410005634	conserved cis-peptide bond; other site
661410005635	pyrimidine utilization protein A; Region: RutA; TIGR03612
661410005636	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
661410005637	active site
661410005638	dimer interface [polypeptide binding]; other site
661410005639	non-prolyl cis peptide bond; other site
661410005640	insertion regions; other site
661410005641	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
661410005642	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
661410005643	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
661410005644	ureidoglycolate hydrolase; Provisional; Region: PRK03606
661410005645	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
661410005646	hypothetical protein; Provisional; Region: PRK11171
661410005647	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
661410005648	Cupin domain; Region: Cupin_2; pfam07883
661410005649	Predicted membrane protein [Function unknown]; Region: COG3748
661410005650	Protein of unknown function (DUF989); Region: DUF989; pfam06181
661410005651	Cytochrome c; Region: Cytochrom_C; pfam00034
661410005652	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410005653	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410005654	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
661410005655	putative effector binding pocket; other site
661410005656	dimerization interface [polypeptide binding]; other site
661410005657	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
661410005658	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
661410005659	active site
661410005660	catalytic site [active]
661410005661	tetramer interface [polypeptide binding]; other site
661410005662	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
661410005663	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
661410005664	active site
661410005665	homotetramer interface [polypeptide binding]; other site
661410005666	Protein of unknown function (DUF808); Region: DUF808; cl01002
661410005667	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410005668	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410005669	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410005670	metal binding site [ion binding]; metal-binding site
661410005671	active site
661410005672	I-site; other site
661410005673	OmpW family; Region: OmpW; cl17427
661410005674	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
661410005675	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
661410005676	Phosphotransferase enzyme family; Region: APH; pfam01636
661410005677	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
661410005678	active site
661410005679	substrate binding site [chemical binding]; other site
661410005680	ATP binding site [chemical binding]; other site
661410005681	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
661410005682	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
661410005683	putative acyl-acceptor binding pocket; other site
661410005684	Protein of unknown function (DUF497); Region: DUF497; pfam04365
661410005685	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
661410005686	Methyltransferase domain; Region: Methyltransf_23; pfam13489
661410005687	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410005688	S-adenosylmethionine binding site [chemical binding]; other site
661410005689	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
661410005690	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
661410005691	methionine sulfoxide reductase B; Provisional; Region: PRK00222
661410005692	SelR domain; Region: SelR; pfam01641
661410005693	methionine sulfoxide reductase A; Provisional; Region: PRK13014
661410005694	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
661410005695	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
661410005696	heme binding site [chemical binding]; other site
661410005697	ferroxidase pore; other site
661410005698	ferroxidase diiron center [ion binding]; other site
661410005699	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410005700	Ligand Binding Site [chemical binding]; other site
661410005701	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
661410005702	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
661410005703	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
661410005704	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
661410005705	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
661410005706	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410005707	FeS/SAM binding site; other site
661410005708	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
661410005709	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
661410005710	active site
661410005711	oligomerization interface [polypeptide binding]; other site
661410005712	metal binding site [ion binding]; metal-binding site
661410005713	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
661410005714	catalytic residues [active]
661410005715	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
661410005716	active site residue [active]
661410005717	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
661410005718	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
661410005719	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
661410005720	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
661410005721	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
661410005722	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
661410005723	active site
661410005724	NTP binding site [chemical binding]; other site
661410005725	metal binding triad [ion binding]; metal-binding site
661410005726	antibiotic binding site [chemical binding]; other site
661410005727	Protein of unknown function DUF86; Region: DUF86; cl01031
661410005728	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
661410005729	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
661410005730	P-loop, Walker A motif; other site
661410005731	Base recognition motif; other site
661410005732	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
661410005733	GAF domain; Region: GAF_2; pfam13185
661410005734	GAF domain; Region: GAF; pfam01590
661410005735	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410005736	putative active site [active]
661410005737	PAS fold; Region: PAS_3; pfam08447
661410005738	heme pocket [chemical binding]; other site
661410005739	PAS domain S-box; Region: sensory_box; TIGR00229
661410005740	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410005741	putative active site [active]
661410005742	heme pocket [chemical binding]; other site
661410005743	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410005744	PAS fold; Region: PAS_3; pfam08447
661410005745	putative active site [active]
661410005746	heme pocket [chemical binding]; other site
661410005747	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410005748	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410005749	dimer interface [polypeptide binding]; other site
661410005750	phosphorylation site [posttranslational modification]
661410005751	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410005752	ATP binding site [chemical binding]; other site
661410005753	Mg2+ binding site [ion binding]; other site
661410005754	G-X-G motif; other site
661410005755	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410005756	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410005757	active site
661410005758	phosphorylation site [posttranslational modification]
661410005759	intermolecular recognition site; other site
661410005760	dimerization interface [polypeptide binding]; other site
661410005761	YcjX-like family, DUF463; Region: DUF463; pfam04317
661410005762	Domain of unknown function (DUF697); Region: DUF697; cl12064
661410005763	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
661410005764	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
661410005765	diaminopimelate decarboxylase; Region: lysA; TIGR01048
661410005766	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
661410005767	active site
661410005768	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
661410005769	substrate binding site [chemical binding]; other site
661410005770	catalytic residues [active]
661410005771	dimer interface [polypeptide binding]; other site
661410005772	Protein of unknown function (DUF1134); Region: DUF1134; pfam06577
661410005773	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
661410005774	RNA/DNA hybrid binding site [nucleotide binding]; other site
661410005775	active site
661410005776	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
661410005777	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
661410005778	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
661410005779	putative active site [active]
661410005780	putative metal binding site [ion binding]; other site
661410005781	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
661410005782	homodimer interface [polypeptide binding]; other site
661410005783	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410005784	catalytic residue [active]
661410005785	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
661410005786	glycerate dehydrogenase; Provisional; Region: PRK06487
661410005787	putative ligand binding site [chemical binding]; other site
661410005788	putative NAD binding site [chemical binding]; other site
661410005789	catalytic site [active]
661410005790	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
661410005791	NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078
661410005792	NADP binding site [chemical binding]; other site
661410005793	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
661410005794	malate--CoA ligase subunit beta; Provisional; Region: PRK14046
661410005795	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
661410005796	CoA-ligase; Region: Ligase_CoA; pfam00549
661410005797	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
661410005798	CoA binding domain; Region: CoA_binding; pfam02629
661410005799	CoA-ligase; Region: Ligase_CoA; pfam00549
661410005800	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
661410005801	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
661410005802	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
661410005803	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
661410005804	Dienelactone hydrolase family; Region: DLH; pfam01738
661410005805	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
661410005806	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
661410005807	aromatic arch; other site
661410005808	DCoH dimer interaction site [polypeptide binding]; other site
661410005809	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
661410005810	DCoH tetramer interaction site [polypeptide binding]; other site
661410005811	substrate binding site [chemical binding]; other site
661410005812	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
661410005813	substrate binding pocket [chemical binding]; other site
661410005814	membrane-bound complex binding site; other site
661410005815	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
661410005816	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410005817	dimer interface [polypeptide binding]; other site
661410005818	conserved gate region; other site
661410005819	putative PBP binding loops; other site
661410005820	ABC-ATPase subunit interface; other site
661410005821	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410005822	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
661410005823	Walker A/P-loop; other site
661410005824	ATP binding site [chemical binding]; other site
661410005825	Q-loop/lid; other site
661410005826	ABC transporter signature motif; other site
661410005827	Walker B; other site
661410005828	D-loop; other site
661410005829	H-loop/switch region; other site
661410005830	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
661410005831	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
661410005832	Trp docking motif [polypeptide binding]; other site
661410005833	dimer interface [polypeptide binding]; other site
661410005834	active site
661410005835	small subunit binding site [polypeptide binding]; other site
661410005836	c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874
661410005837	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
661410005838	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
661410005839	substrate binding pocket [chemical binding]; other site
661410005840	membrane-bound complex binding site; other site
661410005841	hinge residues; other site
661410005842	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
661410005843	catalytic center binding site [active]
661410005844	ATP binding site [chemical binding]; other site
661410005845	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
661410005846	homooctamer interface [polypeptide binding]; other site
661410005847	active site
661410005848	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
661410005849	dihydropteroate synthase; Region: DHPS; TIGR01496
661410005850	substrate binding pocket [chemical binding]; other site
661410005851	dimer interface [polypeptide binding]; other site
661410005852	inhibitor binding site; inhibition site
661410005853	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
661410005854	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410005855	FeS/SAM binding site; other site
661410005856	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
661410005857	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
661410005858	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
661410005859	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
661410005860	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
661410005861	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
661410005862	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
661410005863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410005864	active site
661410005865	phosphorylation site [posttranslational modification]
661410005866	intermolecular recognition site; other site
661410005867	dimerization interface [polypeptide binding]; other site
661410005868	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410005869	DNA binding site [nucleotide binding]
661410005870	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410005871	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410005872	dimer interface [polypeptide binding]; other site
661410005873	phosphorylation site [posttranslational modification]
661410005874	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410005875	ATP binding site [chemical binding]; other site
661410005876	Mg2+ binding site [ion binding]; other site
661410005877	G-X-G motif; other site
661410005878	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
661410005879	domain_subunit interface; other site
661410005880	formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114
661410005881	Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913
661410005882	FTR, proximal lobe; Region: FTR_C; pfam02741
661410005883	formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121
661410005884	Formylmethanofuran dehydrogenase (FMDH) subunit A; Methanogenic bacteria and archea derive the energy for autotrophic growth from methanogenesis, the reduction of CO2 with molecular hydrogen as the electron donor. FMDH catalyzes the first step in...; Region: FMDH_A; cd01304
661410005885	active site
661410005886	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
661410005887	molybdopterin cofactor binding site; other site
661410005888	Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907
661410005889	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
661410005890	NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078
661410005891	NADP binding site [chemical binding]; other site
661410005892	ATP-grasp domain; Region: ATP-grasp_4; cl17255
661410005893	N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264
661410005894	Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria.  It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545
661410005895	trimer interface I [polypeptide binding]; other site
661410005896	putative substrate binding pocket [chemical binding]; other site
661410005897	trimer interface II [polypeptide binding]; other site
661410005898	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
661410005899	ATP-grasp domain; Region: ATP-grasp_4; cl17255
661410005900	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874
661410005901	formaldehyde-activating enzyme; Region: one_C_fae; TIGR03126
661410005902	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
661410005903	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
661410005904	active site
661410005905	Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668
661410005906	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
661410005907	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
661410005908	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
661410005909	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
661410005910	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
661410005911	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
661410005912	putative hydrophobic ligand binding site [chemical binding]; other site
661410005913	protein interface [polypeptide binding]; other site
661410005914	gate; other site
661410005915	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
661410005916	putative hydrophobic ligand binding site [chemical binding]; other site
661410005917	protein interface [polypeptide binding]; other site
661410005918	gate; other site
661410005919	Protein of unknown function (DUF447); Region: DUF447; pfam04289
661410005920	dihydropteroate synthase-related protein; Region: TIGR00284
661410005921	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
661410005922	substrate binding pocket [chemical binding]; other site
661410005923	dimer interface [polypeptide binding]; other site
661410005924	inhibitor binding site; inhibition site
661410005925	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
661410005926	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
661410005927	nucleotide binding site [chemical binding]; other site
661410005928	substrate binding site [chemical binding]; other site
661410005929	hypothetical protein; Provisional; Region: PRK02227
661410005930	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
661410005931	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
661410005932	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
661410005933	ligand binding site [chemical binding]; other site
661410005934	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
661410005935	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
661410005936	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
661410005937	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
661410005938	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
661410005939	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
661410005940	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410005941	Walker A/P-loop; other site
661410005942	ATP binding site [chemical binding]; other site
661410005943	Q-loop/lid; other site
661410005944	ABC transporter signature motif; other site
661410005945	Walker B; other site
661410005946	D-loop; other site
661410005947	H-loop/switch region; other site
661410005948	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
661410005949	ABC-2 type transporter; Region: ABC2_membrane; cl17235
661410005950	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
661410005951	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
661410005952	EF-hand domain pair; Region: EF_hand_5; pfam13499
661410005953	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
661410005954	Ca2+ binding site [ion binding]; other site
661410005955	hypothetical protein; Validated; Region: PRK00068
661410005956	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
661410005957	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
661410005958	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410005959	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
661410005960	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
661410005961	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
661410005962	SLBB domain; Region: SLBB; pfam10531
661410005963	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
661410005964	Chain length determinant protein; Region: Wzz; pfam02706
661410005965	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
661410005966	hypothetical protein; Validated; Region: PRK00153
661410005967	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
661410005968	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
661410005969	active site
661410005970	DNA polymerase III subunit delta'; Validated; Region: PRK08485
661410005971	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
661410005972	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
661410005973	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
661410005974	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
661410005975	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
661410005976	catalytic residues [active]
661410005977	catalytic nucleophile [active]
661410005978	Recombinase; Region: Recombinase; pfam07508
661410005979	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
661410005980	DNA-sulfur modification-associated; Region: DndB; pfam14072
661410005981	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
661410005982	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
661410005983	catalytic residues [active]
661410005984	catalytic nucleophile [active]
661410005985	Presynaptic Site I dimer interface [polypeptide binding]; other site
661410005986	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
661410005987	Synaptic Flat tetramer interface [polypeptide binding]; other site
661410005988	Synaptic Site I dimer interface [polypeptide binding]; other site
661410005989	DNA binding site [nucleotide binding]
661410005990	Protein of unknown function DUF262; Region: DUF262; pfam03235
661410005991	Uncharacterized conserved protein [Function unknown]; Region: COG1479
661410005992	Protein of unknown function DUF262; Region: DUF262; pfam03235
661410005993	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
661410005994	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
661410005995	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
661410005996	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410005997	non-specific DNA binding site [nucleotide binding]; other site
661410005998	salt bridge; other site
661410005999	sequence-specific DNA binding site [nucleotide binding]; other site
661410006000	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
661410006001	DNA methylase; Region: N6_N4_Mtase; cl17433
661410006002	DNA methylase; Region: N6_N4_Mtase; pfam01555
661410006003	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
661410006004	Predicted ATPase [General function prediction only]; Region: COG1485
661410006005	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410006006	putative substrate translocation pore; other site
661410006007	Major Facilitator Superfamily; Region: MFS_1; pfam07690
661410006008	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410006009	Walker A/P-loop; other site
661410006010	ATP binding site [chemical binding]; other site
661410006011	Q-loop/lid; other site
661410006012	ABC transporter signature motif; other site
661410006013	Walker B; other site
661410006014	D-loop; other site
661410006015	H-loop/switch region; other site
661410006016	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410006017	Walker A/P-loop; other site
661410006018	ATP binding site [chemical binding]; other site
661410006019	Q-loop/lid; other site
661410006020	ABC transporter signature motif; other site
661410006021	Walker B; other site
661410006022	D-loop; other site
661410006023	H-loop/switch region; other site
661410006024	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
661410006025	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
661410006026	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
661410006027	P-loop; other site
661410006028	Magnesium ion binding site [ion binding]; other site
661410006029	replication initiation protein RepC; Provisional; Region: PRK13824
661410006030	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
661410006031	putative DNA binding site [nucleotide binding]; other site
661410006032	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
661410006033	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410006034	salt bridge; other site
661410006035	non-specific DNA binding site [nucleotide binding]; other site
661410006036	sequence-specific DNA binding site [nucleotide binding]; other site
661410006037	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
661410006038	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
661410006039	dimer interface [polypeptide binding]; other site
661410006040	ssDNA binding site [nucleotide binding]; other site
661410006041	tetramer (dimer of dimers) interface [polypeptide binding]; other site
661410006042	replication initiation protein RepC; Provisional; Region: PRK13824
661410006043	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
661410006044	putative DNA binding site [nucleotide binding]; other site
661410006045	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
661410006046	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
661410006047	ParB-like nuclease domain; Region: ParBc; pfam02195
661410006048	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
661410006049	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
661410006050	DNA binding residues [nucleotide binding]
661410006051	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
661410006052	P-loop; other site
661410006053	Magnesium ion binding site [ion binding]; other site
661410006054	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
661410006055	Magnesium ion binding site [ion binding]; other site
661410006056	Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 18433868; Product type s : structure
661410006057	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
661410006058	DNA binding site [nucleotide binding]
661410006059	dimer interface [polypeptide binding]; other site
661410006060	active site
661410006061	Int/Topo IB signature motif; other site
661410006062	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
661410006063	oligomeric interface; other site
661410006064	putative active site [active]
661410006065	homodimer interface [polypeptide binding]; other site
661410006066	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
661410006067	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
661410006068	HTH DNA binding domain; Region: HTH_13; pfam11972
661410006069	TniQ; Region: TniQ; pfam06527
661410006070	Bacterial TniB protein; Region: TniB; pfam05621
661410006071	AAA domain; Region: AAA_22; pfam13401
661410006072	Integrase core domain; Region: rve; pfam00665
661410006073	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
661410006074	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
661410006075	HTH DNA binding domain; Region: HTH_13; pfam11972
661410006076	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410006077	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
661410006078	Walker A motif; other site
661410006079	ATP binding site [chemical binding]; other site
661410006080	Walker B motif; other site
661410006081	arginine finger; other site
661410006082	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
661410006083	active site
661410006084	catalytic triad [active]
661410006085	Abortive infection C-terminus; Region: Abi_C; pfam14355
661410006086	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
661410006087	Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246
661410006088	putative regulator PrlF; Provisional; Region: PRK09974
661410006089	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
661410006090	Uncharacterized conserved protein [Function unknown]; Region: COG5489
661410006091	glutamine synthetase; Provisional; Region: glnA; PRK09469
661410006092	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
661410006093	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
661410006094	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
661410006095	Ligand Binding Site [chemical binding]; other site
661410006096	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
661410006097	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
661410006098	plasmid partitioning protein; Provisional; Region: PRK13832
661410006099	ParB-like nuclease domain; Region: ParB; smart00470
661410006100	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
661410006101	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410006102	S-adenosylmethionine binding site [chemical binding]; other site
661410006103	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
661410006104	DEAD-like helicases superfamily; Region: DEXDc; smart00487
661410006105	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
661410006106	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
661410006107	nucleotide binding region [chemical binding]; other site
661410006108	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
661410006109	ATP-binding site [chemical binding]; other site
661410006110	Protein of unknown function (DUF1419); Region: DUF1419; pfam07215
661410006111	PcfJ-like protein; Region: PcfJ; pfam14284
661410006112	Domain of unknown function (DUF4326); Region: DUF4326; pfam14216
661410006113	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
661410006114	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
661410006115	active site
661410006116	metal binding site [ion binding]; metal-binding site
661410006117	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
661410006118	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
661410006119	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410006120	Walker A/P-loop; other site
661410006121	ATP binding site [chemical binding]; other site
661410006122	Q-loop/lid; other site
661410006123	ABC transporter signature motif; other site
661410006124	Walker B; other site
661410006125	D-loop; other site
661410006126	H-loop/switch region; other site
661410006127	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
661410006128	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410006129	dimer interface [polypeptide binding]; other site
661410006130	conserved gate region; other site
661410006131	putative PBP binding loops; other site
661410006132	ABC-ATPase subunit interface; other site
661410006133	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
661410006134	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
661410006135	Helix-turn-helix domain; Region: HTH_17; pfam12728
661410006136	PBP superfamily domain; Region: PBP_like; pfam12727
661410006137	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410006138	Ligand Binding Site [chemical binding]; other site
661410006139	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410006140	Ligand Binding Site [chemical binding]; other site
661410006141	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
661410006142	Sulfate transporter family; Region: Sulfate_transp; pfam00916
661410006143	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
661410006144	Transposase, Mutator family; Region: Transposase_mut; pfam00872
661410006145	MULE transposase domain; Region: MULE; pfam10551
661410006146	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
661410006147	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
661410006148	DNA binding residues [nucleotide binding]
661410006149	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
661410006150	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
661410006151	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
661410006152	C-terminal, alpha helical domain of Class Theta Glutathione S-transferases; Region: GST_C_Theta; cd03183
661410006153	dimer interface [polypeptide binding]; other site
661410006154	substrate binding pocket (H-site) [chemical binding]; other site
661410006155	N-terminal domain interface [polypeptide binding]; other site
661410006156	Transposase, Mutator family; Region: Transposase_mut; pfam00872
661410006157	MULE transposase domain; Region: MULE; pfam10551
661410006158	Transposase, Mutator family; Region: Transposase_mut; pfam00872
661410006159	MULE transposase domain; Region: MULE; pfam10551
661410006160	Predicted amidohydrolase [General function prediction only]; Region: COG0388
661410006161	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
661410006162	putative active site [active]
661410006163	catalytic triad [active]
661410006164	putative dimer interface [polypeptide binding]; other site
661410006165	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
661410006166	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
661410006167	C-terminal domain interface [polypeptide binding]; other site
661410006168	GSH binding site (G-site) [chemical binding]; other site
661410006169	dimer interface [polypeptide binding]; other site
661410006170	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
661410006171	N-terminal domain interface [polypeptide binding]; other site
661410006172	dimer interface [polypeptide binding]; other site
661410006173	substrate binding pocket (H-site) [chemical binding]; other site
661410006174	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
661410006175	CoA-transferase family III; Region: CoA_transf_3; pfam02515
661410006176	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
661410006177	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
661410006178	inhibitor-cofactor binding pocket; inhibition site
661410006179	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410006180	catalytic residue [active]
661410006181	AAA domain; Region: AAA_26; pfam13500
661410006182	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
661410006183	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
661410006184	catalytic core [active]
661410006185	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
661410006186	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410006187	S-adenosylmethionine binding site [chemical binding]; other site
661410006188	Virulence-associated protein E; Region: VirE; pfam05272
661410006189	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
661410006190	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
661410006191	putative C-terminal domain interface [polypeptide binding]; other site
661410006192	putative GSH binding site (G-site) [chemical binding]; other site
661410006193	putative dimer interface [polypeptide binding]; other site
661410006194	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
661410006195	N-terminal domain interface [polypeptide binding]; other site
661410006196	dimer interface [polypeptide binding]; other site
661410006197	substrate binding pocket (H-site) [chemical binding]; other site
661410006198	Uncharacterized conserved protein [Function unknown]; Region: COG3287
661410006199	FIST N domain; Region: FIST; pfam08495
661410006200	FIST C domain; Region: FIST_C; pfam10442
661410006201	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410006202	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410006203	dimer interface [polypeptide binding]; other site
661410006204	phosphorylation site [posttranslational modification]
661410006205	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410006206	ATP binding site [chemical binding]; other site
661410006207	Mg2+ binding site [ion binding]; other site
661410006208	G-X-G motif; other site
661410006209	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410006210	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410006211	active site
661410006212	phosphorylation site [posttranslational modification]
661410006213	intermolecular recognition site; other site
661410006214	dimerization interface [polypeptide binding]; other site
661410006215	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
661410006216	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
661410006217	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
661410006218	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
661410006219	substrate binding pocket [chemical binding]; other site
661410006220	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
661410006221	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
661410006222	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
661410006223	N-acetyl-D-glucosamine binding site [chemical binding]; other site
661410006224	catalytic residue [active]
661410006225	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
661410006226	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
661410006227	putative [4Fe-4S] binding site [ion binding]; other site
661410006228	putative molybdopterin cofactor binding site [chemical binding]; other site
661410006229	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
661410006230	putative molybdopterin cofactor binding site; other site
661410006231	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
661410006232	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
661410006233	Walker A/P-loop; other site
661410006234	ATP binding site [chemical binding]; other site
661410006235	Q-loop/lid; other site
661410006236	ABC transporter signature motif; other site
661410006237	Walker B; other site
661410006238	D-loop; other site
661410006239	H-loop/switch region; other site
661410006240	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
661410006241	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
661410006242	Walker A/P-loop; other site
661410006243	ATP binding site [chemical binding]; other site
661410006244	Q-loop/lid; other site
661410006245	ABC transporter signature motif; other site
661410006246	Walker B; other site
661410006247	D-loop; other site
661410006248	H-loop/switch region; other site
661410006249	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
661410006250	phosphopentomutase; Provisional; Region: PRK05362
661410006251	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
661410006252	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
661410006253	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410006254	Walker A/P-loop; other site
661410006255	ATP binding site [chemical binding]; other site
661410006256	Q-loop/lid; other site
661410006257	ABC transporter signature motif; other site
661410006258	Walker B; other site
661410006259	D-loop; other site
661410006260	H-loop/switch region; other site
661410006261	ABC transporter; Region: ABC_tran_2; pfam12848
661410006262	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
661410006263	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
661410006264	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
661410006265	active site
661410006266	substrate binding site [chemical binding]; other site
661410006267	Mg2+ binding site [ion binding]; other site
661410006268	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
661410006269	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
661410006270	TPP-binding site; other site
661410006271	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
661410006272	PYR/PP interface [polypeptide binding]; other site
661410006273	dimer interface [polypeptide binding]; other site
661410006274	TPP binding site [chemical binding]; other site
661410006275	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
661410006276	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
661410006277	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
661410006278	putative NADP binding site [chemical binding]; other site
661410006279	putative substrate binding site [chemical binding]; other site
661410006280	active site
661410006281	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
661410006282	active site lid residues [active]
661410006283	substrate binding pocket [chemical binding]; other site
661410006284	catalytic residues [active]
661410006285	substrate-Mg2+ binding site; other site
661410006286	aspartate-rich region 1; other site
661410006287	aspartate-rich region 2; other site
661410006288	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
661410006289	active site lid residues [active]
661410006290	substrate binding pocket [chemical binding]; other site
661410006291	catalytic residues [active]
661410006292	substrate-Mg2+ binding site; other site
661410006293	aspartate-rich region 1; other site
661410006294	aspartate-rich region 2; other site
661410006295	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
661410006296	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
661410006297	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
661410006298	Active site cavity [active]
661410006299	catalytic acid [active]
661410006300	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
661410006301	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
661410006302	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
661410006303	substrate-cofactor binding pocket; other site
661410006304	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410006305	catalytic residue [active]
661410006306	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
661410006307	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
661410006308	active site
661410006309	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
661410006310	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
661410006311	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410006312	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
661410006313	Enoylreductase; Region: PKS_ER; smart00829
661410006314	NAD(P) binding site [chemical binding]; other site
661410006315	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
661410006316	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
661410006317	putative NADP binding site [chemical binding]; other site
661410006318	active site
661410006319	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
661410006320	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
661410006321	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
661410006322	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
661410006323	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
661410006324	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
661410006325	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
661410006326	Probable Catalytic site; other site
661410006327	metal-binding site
661410006328	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
661410006329	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
661410006330	Probable Catalytic site; other site
661410006331	metal-binding site
661410006332	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
661410006333	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
661410006334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410006335	putative substrate translocation pore; other site
661410006336	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
661410006337	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
661410006338	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
661410006339	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
661410006340	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
661410006341	Sel1-like repeats; Region: SEL1; smart00671
661410006342	Sel1-like repeats; Region: SEL1; smart00671
661410006343	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
661410006344	putative catalytic site [active]
661410006345	putative phosphate binding site [ion binding]; other site
661410006346	active site
661410006347	metal binding site A [ion binding]; metal-binding site
661410006348	DNA binding site [nucleotide binding]
661410006349	putative AP binding site [nucleotide binding]; other site
661410006350	putative metal binding site B [ion binding]; other site
661410006351	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
661410006352	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
661410006353	acyl-activating enzyme (AAE) consensus motif; other site
661410006354	AMP binding site [chemical binding]; other site
661410006355	active site
661410006356	CoA binding site [chemical binding]; other site
661410006357	Uncharacterized small protein [Function unknown]; Region: COG5570
661410006358	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
661410006359	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
661410006360	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
661410006361	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
661410006362	ATP-grasp domain; Region: ATP-grasp; pfam02222
661410006363	TPR repeat; Region: TPR_11; pfam13414
661410006364	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
661410006365	binding surface
661410006366	TPR motif; other site
661410006367	TPR repeat; Region: TPR_11; pfam13414
661410006368	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
661410006369	binding surface
661410006370	TPR motif; other site
661410006371	TPR repeat; Region: TPR_11; pfam13414
661410006372	Response regulator receiver domain; Region: Response_reg; pfam00072
661410006373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410006374	active site
661410006375	phosphorylation site [posttranslational modification]
661410006376	intermolecular recognition site; other site
661410006377	dimerization interface [polypeptide binding]; other site
661410006378	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
661410006379	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
661410006380	putative active site [active]
661410006381	homoserine dehydrogenase; Provisional; Region: PRK06349
661410006382	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
661410006383	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
661410006384	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
661410006385	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
661410006386	Nucleoside recognition; Region: Gate; pfam07670
661410006387	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
661410006388	Predicted methyltransferase [General function prediction only]; Region: COG3897
661410006389	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
661410006390	putative ADP-binding pocket [chemical binding]; other site
661410006391	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410006392	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
661410006393	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
661410006394	active site
661410006395	DNA binding site [nucleotide binding]
661410006396	Int/Topo IB signature motif; other site
661410006397	catalytic residues [active]
661410006398	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410006399	dimer interface [polypeptide binding]; other site
661410006400	putative CheW interface [polypeptide binding]; other site
661410006401	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
661410006402	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
661410006403	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
661410006404	DNA binding residues [nucleotide binding]
661410006405	dimerization interface [polypeptide binding]; other site
661410006406	Response regulator receiver domain; Region: Response_reg; pfam00072
661410006407	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410006408	active site
661410006409	phosphorylation site [posttranslational modification]
661410006410	intermolecular recognition site; other site
661410006411	dimerization interface [polypeptide binding]; other site
661410006412	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410006413	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410006414	metal binding site [ion binding]; metal-binding site
661410006415	active site
661410006416	I-site; other site
661410006417	Iron permease FTR1 family; Region: FTR1; cl00475
661410006418	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
661410006419	Low molecular weight phosphatase family; Region: LMWPc; cd00115
661410006420	active site
661410006421	hypothetical protein; Provisional; Region: PRK02853
661410006422	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
661410006423	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
661410006424	NAD binding site [chemical binding]; other site
661410006425	dimerization interface [polypeptide binding]; other site
661410006426	product binding site; other site
661410006427	substrate binding site [chemical binding]; other site
661410006428	zinc binding site [ion binding]; other site
661410006429	catalytic residues [active]
661410006430	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
661410006431	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
661410006432	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
661410006433	hinge; other site
661410006434	active site
661410006435	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
661410006436	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
661410006437	substrate-cofactor binding pocket; other site
661410006438	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410006439	catalytic residue [active]
661410006440	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
661410006441	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
661410006442	PhnA protein; Region: PhnA; pfam03831
661410006443	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
661410006444	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
661410006445	hypothetical protein; Provisional; Region: PRK11820
661410006446	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
661410006447	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
661410006448	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
661410006449	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
661410006450	catalytic site [active]
661410006451	G-X2-G-X-G-K; other site
661410006452	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
661410006453	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
661410006454	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
661410006455	Walker A/P-loop; other site
661410006456	ATP binding site [chemical binding]; other site
661410006457	Q-loop/lid; other site
661410006458	ABC transporter signature motif; other site
661410006459	Walker B; other site
661410006460	D-loop; other site
661410006461	H-loop/switch region; other site
661410006462	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
661410006463	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410006464	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
661410006465	putative FMN binding site [chemical binding]; other site
661410006466	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
661410006467	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
661410006468	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
661410006469	N-terminal plug; other site
661410006470	ligand-binding site [chemical binding]; other site
661410006471	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
661410006472	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
661410006473	active site
661410006474	intersubunit interface [polypeptide binding]; other site
661410006475	catalytic residue [active]
661410006476	phosphogluconate dehydratase; Validated; Region: PRK09054
661410006477	6-phosphogluconate dehydratase; Region: edd; TIGR01196
661410006478	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
661410006479	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
661410006480	dimerization interface [polypeptide binding]; other site
661410006481	domain crossover interface; other site
661410006482	redox-dependent activation switch; other site
661410006483	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
661410006484	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
661410006485	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
661410006486	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
661410006487	active site
661410006488	multimer interface [polypeptide binding]; other site
661410006489	Peptidase family M48; Region: Peptidase_M48; cl12018
661410006490	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
661410006491	Protein of unknown function (DUF466); Region: DUF466; pfam04328
661410006492	carbon starvation protein A; Provisional; Region: PRK15015
661410006493	Carbon starvation protein CstA; Region: CstA; pfam02554
661410006494	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
661410006495	Repair protein; Region: Repair_PSII; cl01535
661410006496	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
661410006497	Repair protein; Region: Repair_PSII; pfam04536
661410006498	LemA family; Region: LemA; pfam04011
661410006499	Rdx family; Region: Rdx; cl01407
661410006500	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410006501	PAS domain; Region: PAS_9; pfam13426
661410006502	putative active site [active]
661410006503	heme pocket [chemical binding]; other site
661410006504	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410006505	HWE histidine kinase; Region: HWE_HK; pfam07536
661410006506	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
661410006507	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
661410006508	active site
661410006509	catalytic tetrad [active]
661410006510	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410006511	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410006512	ligand binding site [chemical binding]; other site
661410006513	flexible hinge region; other site
661410006514	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
661410006515	putative switch regulator; other site
661410006516	non-specific DNA interactions [nucleotide binding]; other site
661410006517	DNA binding site [nucleotide binding]
661410006518	sequence specific DNA binding site [nucleotide binding]; other site
661410006519	putative cAMP binding site [chemical binding]; other site
661410006520	glycogen synthase; Provisional; Region: glgA; PRK00654
661410006521	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
661410006522	ADP-binding pocket [chemical binding]; other site
661410006523	homodimer interface [polypeptide binding]; other site
661410006524	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
661410006525	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
661410006526	active site
661410006527	catalytic site [active]
661410006528	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
661410006529	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
661410006530	homodimer interface [polypeptide binding]; other site
661410006531	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
661410006532	active site pocket [active]
661410006533	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194
661410006534	FAD binding pocket [chemical binding]; other site
661410006535	FAD binding motif [chemical binding]; other site
661410006536	phosphate binding motif [ion binding]; other site
661410006537	beta-alpha-beta structure motif; other site
661410006538	NAD binding pocket [chemical binding]; other site
661410006539	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
661410006540	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410006541	PAS fold; Region: PAS_3; pfam08447
661410006542	putative active site [active]
661410006543	heme pocket [chemical binding]; other site
661410006544	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410006545	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410006546	metal binding site [ion binding]; metal-binding site
661410006547	active site
661410006548	I-site; other site
661410006549	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410006550	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
661410006551	Mg++ binding site [ion binding]; other site
661410006552	putative catalytic motif [active]
661410006553	putative substrate binding site [chemical binding]; other site
661410006554	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410006555	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
661410006556	NAD(P) binding site [chemical binding]; other site
661410006557	active site
661410006558	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
661410006559	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
661410006560	Predicted transcriptional regulators [Transcription]; Region: COG1733
661410006561	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
661410006562	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
661410006563	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410006564	NAD(P) binding site [chemical binding]; other site
661410006565	active site
661410006566	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
661410006567	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
661410006568	putative active site [active]
661410006569	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
661410006570	putative active site [active]
661410006571	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
661410006572	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
661410006573	Predicted acetyltransferase [General function prediction only]; Region: COG3153
661410006574	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
661410006575	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
661410006576	dimer interface [polypeptide binding]; other site
661410006577	active site
661410006578	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
661410006579	catalytic residues [active]
661410006580	substrate binding site [chemical binding]; other site
661410006581	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
661410006582	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
661410006583	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
661410006584	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
661410006585	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
661410006586	FMN binding site [chemical binding]; other site
661410006587	active site
661410006588	substrate binding site [chemical binding]; other site
661410006589	catalytic residue [active]
661410006590	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
661410006591	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
661410006592	motif II; other site
661410006593	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
661410006594	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
661410006595	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045
661410006596	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
661410006597	putative phosphate acyltransferase; Provisional; Region: PRK05331
661410006598	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
661410006599	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
661410006600	dimer interface [polypeptide binding]; other site
661410006601	active site
661410006602	CoA binding pocket [chemical binding]; other site
661410006603	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
661410006604	IHF dimer interface [polypeptide binding]; other site
661410006605	IHF - DNA interface [nucleotide binding]; other site
661410006606	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
661410006607	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
661410006608	DNA binding residues [nucleotide binding]
661410006609	PrkA family serine protein kinase; Provisional; Region: PRK15455
661410006610	AAA ATPase domain; Region: AAA_16; pfam13191
661410006611	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
661410006612	hypothetical protein; Provisional; Region: PRK05325
661410006613	SpoVR family protein; Provisional; Region: PRK11767
661410006614	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
661410006615	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
661410006616	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
661410006617	active site
661410006618	substrate binding site [chemical binding]; other site
661410006619	cosubstrate binding site; other site
661410006620	catalytic site [active]
661410006621	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
661410006622	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
661410006623	dimerization interface [polypeptide binding]; other site
661410006624	putative ATP binding site [chemical binding]; other site
661410006625	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
661410006626	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
661410006627	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
661410006628	polyphosphate kinase; Provisional; Region: PRK05443
661410006629	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
661410006630	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
661410006631	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
661410006632	putative domain interface [polypeptide binding]; other site
661410006633	putative active site [active]
661410006634	catalytic site [active]
661410006635	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
661410006636	putative domain interface [polypeptide binding]; other site
661410006637	putative active site [active]
661410006638	catalytic site [active]
661410006639	exopolyphosphatase; Region: exo_poly_only; TIGR03706
661410006640	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
661410006641	aspartate aminotransferase; Provisional; Region: PRK05764
661410006642	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
661410006643	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410006644	homodimer interface [polypeptide binding]; other site
661410006645	catalytic residue [active]
661410006646	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
661410006647	Coenzyme A transferase; Region: CoA_trans; smart00882
661410006648	Coenzyme A transferase; Region: CoA_trans; cl17247
661410006649	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
661410006650	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
661410006651	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410006652	dimerization interface [polypeptide binding]; other site
661410006653	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410006654	dimer interface [polypeptide binding]; other site
661410006655	putative CheW interface [polypeptide binding]; other site
661410006656	30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311
661410006657	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
661410006658	rRNA interaction site [nucleotide binding]; other site
661410006659	S8 interaction site; other site
661410006660	putative laminin-1 binding site; other site
661410006661	Uncharacterized conserved protein [Function unknown]; Region: COG3743
661410006662	elongation factor Ts; Provisional; Region: tsf; PRK09377
661410006663	UBA/TS-N domain; Region: UBA; pfam00627
661410006664	Elongation factor TS; Region: EF_TS; pfam00889
661410006665	Elongation factor TS; Region: EF_TS; pfam00889
661410006666	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
661410006667	putative nucleotide binding site [chemical binding]; other site
661410006668	uridine monophosphate binding site [chemical binding]; other site
661410006669	homohexameric interface [polypeptide binding]; other site
661410006670	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
661410006671	dimer interface [polypeptide binding]; other site
661410006672	substrate binding site [chemical binding]; other site
661410006673	metal binding sites [ion binding]; metal-binding site
661410006674	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
661410006675	Coenzyme A binding pocket [chemical binding]; other site
661410006676	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
661410006677	Putative phosphatase (DUF442); Region: DUF442; cl17385
661410006678	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
661410006679	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
661410006680	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
661410006681	trimer interface [polypeptide binding]; other site
661410006682	active site
661410006683	UDP-GlcNAc binding site [chemical binding]; other site
661410006684	lipid binding site [chemical binding]; lipid-binding site
661410006685	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
661410006686	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
661410006687	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
661410006688	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
661410006689	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
661410006690	Surface antigen; Region: Bac_surface_Ag; pfam01103
661410006691	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
661410006692	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
661410006693	active site
661410006694	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
661410006695	protein binding site [polypeptide binding]; other site
661410006696	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
661410006697	putative substrate binding region [chemical binding]; other site
661410006698	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
661410006699	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
661410006700	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
661410006701	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
661410006702	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
661410006703	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
661410006704	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
661410006705	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
661410006706	catalytic residue [active]
661410006707	putative FPP diphosphate  binding site; other site
661410006708	putative FPP binding hydrophobic cleft; other site
661410006709	dimer interface [polypeptide binding]; other site
661410006710	putative IPP diphosphate binding site; other site
661410006711	ribosome recycling factor; Reviewed; Region: frr; PRK00083
661410006712	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
661410006713	hinge region; other site
661410006714	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
661410006715	HPP family; Region: HPP; pfam04982
661410006716	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
661410006717	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
661410006718	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
661410006719	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
661410006720	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410006721	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
661410006722	dimerization interface [polypeptide binding]; other site
661410006723	substrate binding pocket [chemical binding]; other site
661410006724	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
661410006725	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410006726	NAD(P) binding site [chemical binding]; other site
661410006727	active site
661410006728	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
661410006729	TPP-binding site [chemical binding]; other site
661410006730	dimer interface [polypeptide binding]; other site
661410006731	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
661410006732	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
661410006733	PYR/PP interface [polypeptide binding]; other site
661410006734	dimer interface [polypeptide binding]; other site
661410006735	TPP binding site [chemical binding]; other site
661410006736	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
661410006737	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
661410006738	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
661410006739	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
661410006740	DctM-like transporters; Region: DctM; pfam06808
661410006741	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
661410006742	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
661410006743	Calx-beta domain; Region: Calx-beta; cl02522
661410006744	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
661410006745	generic binding surface II; other site
661410006746	generic binding surface I; other site
661410006747	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
661410006748	putative active site [active]
661410006749	putative catalytic site [active]
661410006750	putative Mg binding site IVb [ion binding]; other site
661410006751	putative phosphate binding site [ion binding]; other site
661410006752	putative DNA binding site [nucleotide binding]; other site
661410006753	putative Mg binding site IVa [ion binding]; other site
661410006754	Bacterial Ig-like domain; Region: Big_5; pfam13205
661410006755	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
661410006756	active site
661410006757	metal binding site [ion binding]; metal-binding site
661410006758	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
661410006759	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
661410006760	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
661410006761	active site
661410006762	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
661410006763	catalytic triad [active]
661410006764	dimer interface [polypeptide binding]; other site
661410006765	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
661410006766	Nitrogen regulatory protein P-II; Region: P-II; smart00938
661410006767	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
661410006768	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
661410006769	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
661410006770	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
661410006771	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
661410006772	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
661410006773	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
661410006774	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
661410006775	PAS fold; Region: PAS_4; pfam08448
661410006776	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410006777	PAS fold; Region: PAS_3; pfam08447
661410006778	putative active site [active]
661410006779	heme pocket [chemical binding]; other site
661410006780	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410006781	HWE histidine kinase; Region: HWE_HK; smart00911
661410006782	Probable phenylalanyl-tRNA synthetase alpha chain; Region: PLN02853
661410006783	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
661410006784	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
661410006785	putative molybdopterin cofactor binding site [chemical binding]; other site
661410006786	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
661410006787	putative molybdopterin cofactor binding site; other site
661410006788	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
661410006789	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
661410006790	quinone interaction residues [chemical binding]; other site
661410006791	active site
661410006792	catalytic residues [active]
661410006793	FMN binding site [chemical binding]; other site
661410006794	substrate binding site [chemical binding]; other site
661410006795	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
661410006796	Predicted transcriptional regulator [Transcription]; Region: COG2932
661410006797	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
661410006798	Catalytic site [active]
661410006799	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
661410006800	serine acetyltransferase; Provisional; Region: cysE; PRK11132
661410006801	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
661410006802	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
661410006803	trimer interface [polypeptide binding]; other site
661410006804	active site
661410006805	substrate binding site [chemical binding]; other site
661410006806	CoA binding site [chemical binding]; other site
661410006807	anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154
661410006808	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410006809	non-specific DNA binding site [nucleotide binding]; other site
661410006810	salt bridge; other site
661410006811	sequence-specific DNA binding site [nucleotide binding]; other site
661410006812	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
661410006813	ADP binding site [chemical binding]; other site
661410006814	magnesium binding site [ion binding]; other site
661410006815	putative shikimate binding site; other site
661410006816	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
661410006817	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410006818	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
661410006819	dimer interface [polypeptide binding]; other site
661410006820	phosphorylation site [posttranslational modification]
661410006821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410006822	ATP binding site [chemical binding]; other site
661410006823	Mg2+ binding site [ion binding]; other site
661410006824	G-X-G motif; other site
661410006825	osmolarity response regulator; Provisional; Region: ompR; PRK09468
661410006826	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410006827	active site
661410006828	phosphorylation site [posttranslational modification]
661410006829	intermolecular recognition site; other site
661410006830	dimerization interface [polypeptide binding]; other site
661410006831	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410006832	DNA binding site [nucleotide binding]
661410006833	Response regulator receiver domain; Region: Response_reg; pfam00072
661410006834	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
661410006835	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410006836	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410006837	dimer interface [polypeptide binding]; other site
661410006838	phosphorylation site [posttranslational modification]
661410006839	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410006840	ATP binding site [chemical binding]; other site
661410006841	Mg2+ binding site [ion binding]; other site
661410006842	G-X-G motif; other site
661410006843	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
661410006844	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
661410006845	active site
661410006846	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
661410006847	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410006848	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410006849	ligand binding site [chemical binding]; other site
661410006850	flexible hinge region; other site
661410006851	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
661410006852	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
661410006853	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
661410006854	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
661410006855	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
661410006856	Moco binding site; other site
661410006857	metal coordination site [ion binding]; other site
661410006858	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
661410006859	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
661410006860	FAD binding pocket [chemical binding]; other site
661410006861	FAD binding motif [chemical binding]; other site
661410006862	phosphate binding motif [ion binding]; other site
661410006863	beta-alpha-beta structure motif; other site
661410006864	NAD binding pocket [chemical binding]; other site
661410006865	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530
661410006866	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
661410006867	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
661410006868	hinge; other site
661410006869	active site
661410006870	cytidylate kinase; Provisional; Region: cmk; PRK00023
661410006871	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
661410006872	CMP-binding site; other site
661410006873	The sites determining sugar specificity; other site
661410006874	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
661410006875	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
661410006876	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
661410006877	homodimer interface [polypeptide binding]; other site
661410006878	active site
661410006879	TDP-binding site; other site
661410006880	acceptor substrate-binding pocket; other site
661410006881	Creatinine amidohydrolase; Region: Creatininase; pfam02633
661410006882	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410006883	PAS domain; Region: PAS_9; pfam13426
661410006884	putative active site [active]
661410006885	heme pocket [chemical binding]; other site
661410006886	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410006887	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410006888	metal binding site [ion binding]; metal-binding site
661410006889	active site
661410006890	I-site; other site
661410006891	CsbD-like; Region: CsbD; pfam05532
661410006892	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
661410006893	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
661410006894	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410006895	putative substrate translocation pore; other site
661410006896	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
661410006897	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
661410006898	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
661410006899	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
661410006900	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
661410006901	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
661410006902	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
661410006903	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
661410006904	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
661410006905	acyl-activating enzyme (AAE) consensus motif; other site
661410006906	acyl-activating enzyme (AAE) consensus motif; other site
661410006907	putative AMP binding site [chemical binding]; other site
661410006908	putative active site [active]
661410006909	putative CoA binding site [chemical binding]; other site
661410006910	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410006911	Major Facilitator Superfamily; Region: MFS_1; pfam07690
661410006912	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
661410006913	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410006914	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
661410006915	dimerization interface [polypeptide binding]; other site
661410006916	substrate binding pocket [chemical binding]; other site
661410006917	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
661410006918	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
661410006919	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
661410006920	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
661410006921	motif II; other site
661410006922	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410006923	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410006924	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
661410006925	putative effector binding pocket; other site
661410006926	dimerization interface [polypeptide binding]; other site
661410006927	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
661410006928	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
661410006929	Zn binding site [ion binding]; other site
661410006930	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
661410006931	Zn binding site [ion binding]; other site
661410006932	Predicted esterase [General function prediction only]; Region: COG0400
661410006933	putative hydrolase; Provisional; Region: PRK11460
661410006934	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
661410006935	AAA domain; Region: AAA_23; pfam13476
661410006936	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
661410006937	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
661410006938	S17 interaction site [polypeptide binding]; other site
661410006939	S8 interaction site; other site
661410006940	16S rRNA interaction site [nucleotide binding]; other site
661410006941	streptomycin interaction site [chemical binding]; other site
661410006942	23S rRNA interaction site [nucleotide binding]; other site
661410006943	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
661410006944	30S ribosomal protein S7; Validated; Region: PRK05302
661410006945	elongation factor G; Reviewed; Region: PRK00007
661410006946	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
661410006947	G1 box; other site
661410006948	putative GEF interaction site [polypeptide binding]; other site
661410006949	GTP/Mg2+ binding site [chemical binding]; other site
661410006950	Switch I region; other site
661410006951	G2 box; other site
661410006952	G3 box; other site
661410006953	Switch II region; other site
661410006954	G4 box; other site
661410006955	G5 box; other site
661410006956	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
661410006957	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
661410006958	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
661410006959	elongation factor Tu; Reviewed; Region: PRK00049
661410006960	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
661410006961	G1 box; other site
661410006962	GEF interaction site [polypeptide binding]; other site
661410006963	GTP/Mg2+ binding site [chemical binding]; other site
661410006964	Switch I region; other site
661410006965	G2 box; other site
661410006966	G3 box; other site
661410006967	Switch II region; other site
661410006968	G4 box; other site
661410006969	G5 box; other site
661410006970	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
661410006971	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
661410006972	Antibiotic Binding Site [chemical binding]; other site
661410006973	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
661410006974	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
661410006975	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
661410006976	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
661410006977	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
661410006978	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
661410006979	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
661410006980	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
661410006981	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
661410006982	putative translocon binding site; other site
661410006983	protein-rRNA interface [nucleotide binding]; other site
661410006984	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
661410006985	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
661410006986	G-X-X-G motif; other site
661410006987	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
661410006988	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
661410006989	23S rRNA interface [nucleotide binding]; other site
661410006990	5S rRNA interface [nucleotide binding]; other site
661410006991	putative antibiotic binding site [chemical binding]; other site
661410006992	L25 interface [polypeptide binding]; other site
661410006993	L27 interface [polypeptide binding]; other site
661410006994	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
661410006995	23S rRNA interface [nucleotide binding]; other site
661410006996	putative translocon interaction site; other site
661410006997	signal recognition particle (SRP54) interaction site; other site
661410006998	L23 interface [polypeptide binding]; other site
661410006999	trigger factor interaction site; other site
661410007000	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
661410007001	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410007002	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
661410007003	Walker A motif; other site
661410007004	ATP binding site [chemical binding]; other site
661410007005	Walker B motif; other site
661410007006	arginine finger; other site
661410007007	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
661410007008	nudix motif; other site
661410007009	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
661410007010	MarR family; Region: MarR; pfam01047
661410007011	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
661410007012	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
661410007013	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
661410007014	alphaNTD - beta interaction site [polypeptide binding]; other site
661410007015	alphaNTD homodimer interface [polypeptide binding]; other site
661410007016	alphaNTD - beta' interaction site [polypeptide binding]; other site
661410007017	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
661410007018	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
661410007019	30S ribosomal protein S11; Validated; Region: PRK05309
661410007020	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
661410007021	30S ribosomal protein S13; Region: bact_S13; TIGR03631
661410007022	adenylate kinase; Reviewed; Region: adk; PRK00279
661410007023	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
661410007024	AMP-binding site [chemical binding]; other site
661410007025	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
661410007026	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
661410007027	SecY translocase; Region: SecY; pfam00344
661410007028	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
661410007029	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
661410007030	23S rRNA binding site [nucleotide binding]; other site
661410007031	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
661410007032	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
661410007033	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
661410007034	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
661410007035	5S rRNA interface [nucleotide binding]; other site
661410007036	23S rRNA interface [nucleotide binding]; other site
661410007037	L5 interface [polypeptide binding]; other site
661410007038	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
661410007039	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
661410007040	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
661410007041	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
661410007042	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
661410007043	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
661410007044	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
661410007045	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
661410007046	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
661410007047	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
661410007048	RNA binding site [nucleotide binding]; other site
661410007049	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
661410007050	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
661410007051	Catalytic site; other site
661410007052	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
661410007053	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410007054	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410007055	metal binding site [ion binding]; metal-binding site
661410007056	active site
661410007057	I-site; other site
661410007058	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
661410007059	salicylate hydroxylase; Provisional; Region: PRK08163
661410007060	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
661410007061	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
661410007062	Predicted transcriptional regulator [Transcription]; Region: COG3655
661410007063	non-specific DNA binding site [nucleotide binding]; other site
661410007064	salt bridge; other site
661410007065	sequence-specific DNA binding site [nucleotide binding]; other site
661410007066	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
661410007067	active site
661410007068	hypothetical protein; Reviewed; Region: PRK00024
661410007069	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
661410007070	MPN+ (JAMM) motif; other site
661410007071	Zinc-binding site [ion binding]; other site
661410007072	Uncharacterized conserved protein [Function unknown]; Region: COG2308
661410007073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
661410007074	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
661410007075	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
661410007076	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
661410007077	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
661410007078	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
661410007079	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
661410007080	active site
661410007081	NAD-dependent deacetylase; Provisional; Region: PRK00481
661410007082	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
661410007083	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
661410007084	Domain of unknown function DUF21; Region: DUF21; pfam01595
661410007085	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
661410007086	Transporter associated domain; Region: CorC_HlyC; smart01091
661410007087	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
661410007088	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
661410007089	Probable Catalytic site; other site
661410007090	metal-binding site
661410007091	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410007092	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
661410007093	similar to hypothetical protein; Evidence 5 : No homology to any previously reported sequences
661410007094	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
661410007095	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
661410007096	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
661410007097	protein binding site [polypeptide binding]; other site
661410007098	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
661410007099	protein binding site [polypeptide binding]; other site
661410007100	Phasin protein; Region: Phasin_2; cl11491
661410007101	phasin; Region: phasin_2; TIGR01985
661410007102	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
661410007103	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410007104	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410007105	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
661410007106	PAS domain S-box; Region: sensory_box; TIGR00229
661410007107	PAS domain; Region: PAS; smart00091
661410007108	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410007109	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410007110	metal binding site [ion binding]; metal-binding site
661410007111	active site
661410007112	I-site; other site
661410007113	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410007114	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
661410007115	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
661410007116	active site
661410007117	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
661410007118	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
661410007119	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
661410007120	CysD dimerization site [polypeptide binding]; other site
661410007121	G1 box; other site
661410007122	putative GEF interaction site [polypeptide binding]; other site
661410007123	GTP/Mg2+ binding site [chemical binding]; other site
661410007124	Switch I region; other site
661410007125	G2 box; other site
661410007126	G3 box; other site
661410007127	Switch II region; other site
661410007128	G4 box; other site
661410007129	G5 box; other site
661410007130	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
661410007131	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
661410007132	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
661410007133	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
661410007134	Active Sites [active]
661410007135	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
661410007136	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
661410007137	Active Sites [active]
661410007138	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
661410007139	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
661410007140	dimerization interface [polypeptide binding]; other site
661410007141	putative DNA binding site [nucleotide binding]; other site
661410007142	putative Zn2+ binding site [ion binding]; other site
661410007143	AsnC family; Region: AsnC_trans_reg; pfam01037
661410007144	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
661410007145	Flavodoxin; Region: Flavodoxin_1; pfam00258
661410007146	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
661410007147	FAD binding pocket [chemical binding]; other site
661410007148	FAD binding motif [chemical binding]; other site
661410007149	catalytic residues [active]
661410007150	NAD binding pocket [chemical binding]; other site
661410007151	phosphate binding motif [ion binding]; other site
661410007152	beta-alpha-beta structure motif; other site
661410007153	sulfite reductase subunit beta; Provisional; Region: PRK13504
661410007154	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
661410007155	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
661410007156	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
661410007157	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
661410007158	N-terminal plug; other site
661410007159	ligand-binding site [chemical binding]; other site
661410007160	pantoate--beta-alanine ligase; Region: panC; TIGR00018
661410007161	Pantoate-beta-alanine ligase; Region: PanC; cd00560
661410007162	active site
661410007163	ATP-binding site [chemical binding]; other site
661410007164	pantoate-binding site; other site
661410007165	HXXH motif; other site
661410007166	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
661410007167	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410007168	non-specific DNA binding site [nucleotide binding]; other site
661410007169	salt bridge; other site
661410007170	sequence-specific DNA binding site [nucleotide binding]; other site
661410007171	Cupin domain; Region: Cupin_2; pfam07883
661410007172	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
661410007173	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
661410007174	dimer interface [polypeptide binding]; other site
661410007175	ssDNA binding site [nucleotide binding]; other site
661410007176	tetramer (dimer of dimers) interface [polypeptide binding]; other site
661410007177	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
661410007178	Prostaglandin dehydrogenases; Region: PGDH; cd05288
661410007179	NAD(P) binding site [chemical binding]; other site
661410007180	substrate binding site [chemical binding]; other site
661410007181	dimer interface [polypeptide binding]; other site
661410007182	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
661410007183	Predicted periplasmic protein [Function unknown]; Region: COG3698
661410007184	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
661410007185	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
661410007186	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
661410007187	active site
661410007188	FMN binding site [chemical binding]; other site
661410007189	substrate binding site [chemical binding]; other site
661410007190	homotetramer interface [polypeptide binding]; other site
661410007191	catalytic residue [active]
661410007192	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
661410007193	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
661410007194	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
661410007195	Uncharacterized conserved protein [Function unknown]; Region: COG2835
661410007196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
661410007197	PAS domain; Region: PAS_9; pfam13426
661410007198	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410007199	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410007200	dimer interface [polypeptide binding]; other site
661410007201	phosphorylation site [posttranslational modification]
661410007202	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410007203	ATP binding site [chemical binding]; other site
661410007204	Mg2+ binding site [ion binding]; other site
661410007205	G-X-G motif; other site
661410007206	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
661410007207	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
661410007208	PilZ domain; Region: PilZ; pfam07238
661410007209	PilZ domain; Region: PilZ; pfam07238
661410007210	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
661410007211	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
661410007212	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
661410007213	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
661410007214	FOG: CBS domain [General function prediction only]; Region: COG0517
661410007215	hypothetical protein; Provisional; Region: PRK10279
661410007216	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
661410007217	active site
661410007218	nucleophile elbow; other site
661410007219	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
661410007220	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
661410007221	GTP cyclohydrolase I; Provisional; Region: PLN03044
661410007222	active site
661410007223	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
661410007224	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
661410007225	trimerization site [polypeptide binding]; other site
661410007226	active site
661410007227	hypothetical protein; Validated; Region: PRK00041
661410007228	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
661410007229	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
661410007230	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
661410007231	FtsX-like permease family; Region: FtsX; pfam02687
661410007232	FtsX-like permease family; Region: FtsX; pfam02687
661410007233	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410007234	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410007235	ATP binding site [chemical binding]; other site
661410007236	Mg2+ binding site [ion binding]; other site
661410007237	G-X-G motif; other site
661410007238	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
661410007239	active site
661410007240	hydrophilic channel; other site
661410007241	dimerization interface [polypeptide binding]; other site
661410007242	catalytic residues [active]
661410007243	active site lid [active]
661410007244	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
661410007245	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
661410007246	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
661410007247	Catalytic site [active]
661410007248	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
661410007249	Catalytic site [active]
661410007250	ribonuclease III; Reviewed; Region: rnc; PRK00102
661410007251	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
661410007252	dimerization interface [polypeptide binding]; other site
661410007253	active site
661410007254	metal binding site [ion binding]; metal-binding site
661410007255	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
661410007256	dsRNA binding site [nucleotide binding]; other site
661410007257	GTPase Era; Reviewed; Region: era; PRK00089
661410007258	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
661410007259	G1 box; other site
661410007260	GTP/Mg2+ binding site [chemical binding]; other site
661410007261	Switch I region; other site
661410007262	G2 box; other site
661410007263	Switch II region; other site
661410007264	G3 box; other site
661410007265	G4 box; other site
661410007266	G5 box; other site
661410007267	KH domain; Region: KH_2; pfam07650
661410007268	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
661410007269	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410007270	S-adenosylmethionine binding site [chemical binding]; other site
661410007271	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
661410007272	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
661410007273	RNA binding surface [nucleotide binding]; other site
661410007274	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
661410007275	active site
661410007276	uracil binding [chemical binding]; other site
661410007277	Sel1-like repeats; Region: SEL1; smart00671
661410007278	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
661410007279	Sel1-like repeats; Region: SEL1; smart00671
661410007280	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
661410007281	Sel1-like repeats; Region: SEL1; smart00671
661410007282	Sel1-like repeats; Region: SEL1; smart00671
661410007283	Sel1-like repeats; Region: SEL1; smart00671
661410007284	Sel1-like repeats; Region: SEL1; smart00671
661410007285	Sel1-like repeats; Region: SEL1; smart00671
661410007286	potassium uptake protein; Region: kup; TIGR00794
661410007287	K+ potassium transporter; Region: K_trans; pfam02705
661410007288	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
661410007289	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
661410007290	putative active site [active]
661410007291	Ap4A binding site [chemical binding]; other site
661410007292	nudix motif; other site
661410007293	putative metal binding site [ion binding]; other site
661410007294	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
661410007295	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410007296	putative CheW interface [polypeptide binding]; other site
661410007297	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
661410007298	NodB motif; other site
661410007299	putative active site [active]
661410007300	putative catalytic site [active]
661410007301	Zn binding site [ion binding]; other site
661410007302	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
661410007303	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
661410007304	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
661410007305	protein binding site [polypeptide binding]; other site
661410007306	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
661410007307	Catalytic dyad [active]
661410007308	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
661410007309	Peptidase family M23; Region: Peptidase_M23; pfam01551
661410007310	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
661410007311	citrate-proton symporter; Provisional; Region: PRK15075
661410007312	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410007313	putative substrate translocation pore; other site
661410007314	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001
661410007315	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410007316	metal binding site [ion binding]; metal-binding site
661410007317	active site
661410007318	I-site; other site
661410007319	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410007320	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
661410007321	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
661410007322	putative catalytic residue [active]
661410007323	argininosuccinate synthase; Provisional; Region: PRK13820
661410007324	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
661410007325	ANP binding site [chemical binding]; other site
661410007326	Substrate Binding Site II [chemical binding]; other site
661410007327	Substrate Binding Site I [chemical binding]; other site
661410007328	Domain of unknown function (DUF4424); Region: DUF4424; pfam14415
661410007329	phosphoglycolate phosphatase; Provisional; Region: PRK13222
661410007330	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
661410007331	motif II; other site
661410007332	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
661410007333	tetramer (dimer of dimers) interface [polypeptide binding]; other site
661410007334	active site
661410007335	dimer interface [polypeptide binding]; other site
661410007336	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
661410007337	O-Antigen ligase; Region: Wzy_C; pfam04932
661410007338	glutathione reductase; Validated; Region: PRK06116
661410007339	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
661410007340	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
661410007341	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
661410007342	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
661410007343	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
661410007344	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
661410007345	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
661410007346	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410007347	FeS/SAM binding site; other site
661410007348	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
661410007349	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
661410007350	Fe-S cluster binding site [ion binding]; other site
661410007351	active site
661410007352	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
661410007353	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
661410007354	NAD binding site [chemical binding]; other site
661410007355	catalytic Zn binding site [ion binding]; other site
661410007356	structural Zn binding site [ion binding]; other site
661410007357	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
661410007358	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
661410007359	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
661410007360	N-acetyl-D-glucosamine binding site [chemical binding]; other site
661410007361	catalytic residue [active]
661410007362	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
661410007363	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
661410007364	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
661410007365	putative C-terminal domain interface [polypeptide binding]; other site
661410007366	putative GSH binding site (G-site) [chemical binding]; other site
661410007367	putative dimer interface [polypeptide binding]; other site
661410007368	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
661410007369	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
661410007370	putative heme binding pocket [chemical binding]; other site
661410007371	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
661410007372	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
661410007373	putative FMN binding site [chemical binding]; other site
661410007374	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
661410007375	DNA-binding site [nucleotide binding]; DNA binding site
661410007376	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
661410007377	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
661410007378	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410007379	homodimer interface [polypeptide binding]; other site
661410007380	catalytic residue [active]
661410007381	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
661410007382	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
661410007383	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
661410007384	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
661410007385	active site
661410007386	dimer interface [polypeptide binding]; other site
661410007387	motif 1; other site
661410007388	motif 2; other site
661410007389	motif 3; other site
661410007390	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
661410007391	anticodon binding site; other site
661410007392	fructokinase; Reviewed; Region: PRK09557
661410007393	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
661410007394	nucleotide binding site [chemical binding]; other site
661410007395	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
661410007396	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
661410007397	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
661410007398	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
661410007399	active site
661410007400	HIGH motif; other site
661410007401	nucleotide binding site [chemical binding]; other site
661410007402	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
661410007403	active site
661410007404	KMSKS motif; other site
661410007405	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
661410007406	tRNA binding surface [nucleotide binding]; other site
661410007407	anticodon binding site; other site
661410007408	lipoprotein signal peptidase; Provisional; Region: PRK14796
661410007409	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
661410007410	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
661410007411	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
661410007412	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
661410007413	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
661410007414	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
661410007415	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
661410007416	Zn binding site [ion binding]; other site
661410007417	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
661410007418	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
661410007419	Zn binding site [ion binding]; other site
661410007420	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
661410007421	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
661410007422	FAD binding pocket [chemical binding]; other site
661410007423	FAD binding motif [chemical binding]; other site
661410007424	phosphate binding motif [ion binding]; other site
661410007425	beta-alpha-beta structure motif; other site
661410007426	NAD binding pocket [chemical binding]; other site
661410007427	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
661410007428	AAA domain; Region: AAA_26; pfam13500
661410007429	Response regulator receiver domain; Region: Response_reg; pfam00072
661410007430	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410007431	active site
661410007432	phosphorylation site [posttranslational modification]
661410007433	intermolecular recognition site; other site
661410007434	dimerization interface [polypeptide binding]; other site
661410007435	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
661410007436	FOG: WD40 repeat [General function prediction only]; Region: COG2319
661410007437	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
661410007438	structural tetrad; other site
661410007439	Protein of unknown function (DUF2937); Region: DUF2937; pfam11157
661410007440	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
661410007441	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
661410007442	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
661410007443	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
661410007444	feedback inhibition sensing region; other site
661410007445	homohexameric interface [polypeptide binding]; other site
661410007446	nucleotide binding site [chemical binding]; other site
661410007447	N-acetyl-L-glutamate binding site [chemical binding]; other site
661410007448	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
661410007449	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
661410007450	MOSC domain; Region: MOSC; pfam03473
661410007451	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
661410007452	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
661410007453	MOSC domain; Region: MOSC; pfam03473
661410007454	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
661410007455	Clp amino terminal domain; Region: Clp_N; pfam02861
661410007456	Clp amino terminal domain; Region: Clp_N; pfam02861
661410007457	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410007458	Walker A motif; other site
661410007459	ATP binding site [chemical binding]; other site
661410007460	Walker B motif; other site
661410007461	arginine finger; other site
661410007462	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410007463	Walker A motif; other site
661410007464	ATP binding site [chemical binding]; other site
661410007465	Walker B motif; other site
661410007466	arginine finger; other site
661410007467	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
661410007468	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
661410007469	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
661410007470	active site
661410007471	metal binding site [ion binding]; metal-binding site
661410007472	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
661410007473	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
661410007474	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
661410007475	G1 box; other site
661410007476	GTP/Mg2+ binding site [chemical binding]; other site
661410007477	Switch I region; other site
661410007478	G2 box; other site
661410007479	G3 box; other site
661410007480	Switch II region; other site
661410007481	G4 box; other site
661410007482	G5 box; other site
661410007483	membrane protein insertase; Provisional; Region: PRK01318
661410007484	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
661410007485	Ribonuclease P; Region: Ribonuclease_P; pfam00825
661410007486	Protein of unknown function (DUF1465); Region: DUF1465; pfam07323
661410007487	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
661410007488	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
661410007489	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
661410007490	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
661410007491	Walker A/P-loop; other site
661410007492	ATP binding site [chemical binding]; other site
661410007493	Q-loop/lid; other site
661410007494	ABC transporter signature motif; other site
661410007495	Walker B; other site
661410007496	D-loop; other site
661410007497	H-loop/switch region; other site
661410007498	D-cysteine desulfhydrase; Validated; Region: PRK03910
661410007499	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
661410007500	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
661410007501	catalytic residue [active]
661410007502	hypothetical protein; Validated; Region: PRK09039
661410007503	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
661410007504	ligand binding site [chemical binding]; other site
661410007505	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
661410007506	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
661410007507	putative active site [active]
661410007508	metal binding site [ion binding]; metal-binding site
661410007509	homodimer binding site [polypeptide binding]; other site
661410007510	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
661410007511	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
661410007512	Cell division protein ZapA; Region: ZapA; pfam05164
661410007513	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
661410007514	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
661410007515	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
661410007516	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
661410007517	Phosphoglycerate kinase; Region: PGK; pfam00162
661410007518	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
661410007519	substrate binding site [chemical binding]; other site
661410007520	hinge regions; other site
661410007521	ADP binding site [chemical binding]; other site
661410007522	catalytic site [active]
661410007523	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
661410007524	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
661410007525	intersubunit interface [polypeptide binding]; other site
661410007526	active site
661410007527	zinc binding site [ion binding]; other site
661410007528	Na+ binding site [ion binding]; other site
661410007529	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
661410007530	active site
661410007531	thiamine phosphate binding site [chemical binding]; other site
661410007532	pyrophosphate binding site [ion binding]; other site
661410007533	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
661410007534	Sel1-like repeats; Region: SEL1; smart00671
661410007535	Sel1-like repeats; Region: SEL1; smart00671
661410007536	Sel1-like repeats; Region: SEL1; smart00671
661410007537	amino acid transporter; Region: 2A0306; TIGR00909
661410007538	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
661410007539	Uncharacterized conserved protein [Function unknown]; Region: COG0062
661410007540	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
661410007541	putative substrate binding site [chemical binding]; other site
661410007542	putative ATP binding site [chemical binding]; other site
661410007543	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
661410007544	Nitrogen regulatory protein P-II; Region: P-II; smart00938
661410007545	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
661410007546	glutaminase; Provisional; Region: PRK00971
661410007547	glutamine synthetase; Region: PLN02284
661410007548	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
661410007549	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
661410007550	glutamine synthetase; Provisional; Region: glnA; PRK09469
661410007551	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
661410007552	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
661410007553	Predicted flavoprotein [General function prediction only]; Region: COG0431
661410007554	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
661410007555	ribonuclease R; Region: RNase_R; TIGR02063
661410007556	RNB domain; Region: RNB; pfam00773
661410007557	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
661410007558	RNA binding site [nucleotide binding]; other site
661410007559	Protein of unknown function (DUF983); Region: DUF983; cl02211
661410007560	NUDIX domain; Region: NUDIX; pfam00293
661410007561	nudix motif; other site
661410007562	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410007563	PAS domain; Region: PAS_9; pfam13426
661410007564	putative active site [active]
661410007565	heme pocket [chemical binding]; other site
661410007566	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410007567	PAS domain; Region: PAS_9; pfam13426
661410007568	putative active site [active]
661410007569	heme pocket [chemical binding]; other site
661410007570	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410007571	PAS domain; Region: PAS_9; pfam13426
661410007572	putative active site [active]
661410007573	heme pocket [chemical binding]; other site
661410007574	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410007575	dimer interface [polypeptide binding]; other site
661410007576	putative CheW interface [polypeptide binding]; other site
661410007577	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
661410007578	putative NAD(P) binding site [chemical binding]; other site
661410007579	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
661410007580	epoxyqueuosine reductase; Region: TIGR00276
661410007581	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
661410007582	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
661410007583	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
661410007584	C-terminal domain interface [polypeptide binding]; other site
661410007585	GSH binding site (G-site) [chemical binding]; other site
661410007586	dimer interface [polypeptide binding]; other site
661410007587	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
661410007588	N-terminal domain interface [polypeptide binding]; other site
661410007589	dimer interface [polypeptide binding]; other site
661410007590	substrate binding pocket (H-site) [chemical binding]; other site
661410007591	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
661410007592	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
661410007593	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
661410007594	heterodimer interface [polypeptide binding]; other site
661410007595	substrate interaction site [chemical binding]; other site
661410007596	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
661410007597	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
661410007598	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
661410007599	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
661410007600	NAD binding site [chemical binding]; other site
661410007601	substrate binding site [chemical binding]; other site
661410007602	homodimer interface [polypeptide binding]; other site
661410007603	active site
661410007604	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
661410007605	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
661410007606	NADP binding site [chemical binding]; other site
661410007607	active site
661410007608	putative substrate binding site [chemical binding]; other site
661410007609	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
661410007610	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
661410007611	substrate binding site; other site
661410007612	tetramer interface; other site
661410007613	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410007614	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410007615	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898
661410007616	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
661410007617	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410007618	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410007619	Radical SAM superfamily; Region: Radical_SAM; pfam04055
661410007620	FeS/SAM binding site; other site
661410007621	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
661410007622	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
661410007623	Multicopper oxidase; Region: Cu-oxidase; pfam00394
661410007624	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
661410007625	trigger factor; Provisional; Region: tig; PRK01490
661410007626	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
661410007627	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
661410007628	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
661410007629	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
661410007630	oligomer interface [polypeptide binding]; other site
661410007631	active site residues [active]
661410007632	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
661410007633	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
661410007634	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410007635	Walker A motif; other site
661410007636	ATP binding site [chemical binding]; other site
661410007637	Walker B motif; other site
661410007638	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
661410007639	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
661410007640	Found in ATP-dependent protease La (LON); Region: LON; smart00464
661410007641	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410007642	Walker A motif; other site
661410007643	ATP binding site [chemical binding]; other site
661410007644	Walker B motif; other site
661410007645	arginine finger; other site
661410007646	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
661410007647	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
661410007648	putative ADP-binding pocket [chemical binding]; other site
661410007649	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410007650	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
661410007651	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
661410007652	Methyltransferase domain; Region: Methyltransf_31; pfam13847
661410007653	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410007654	S-adenosylmethionine binding site [chemical binding]; other site
661410007655	YqcI/YcgG family; Region: YqcI_YcgG; pfam08892
661410007656	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
661410007657	OPT oligopeptide transporter protein; Region: OPT; cl14607
661410007658	putative oligopeptide transporter, OPT family; Region: TIGR00733
661410007659	ABC-2 type transporter; Region: ABC2_membrane; cl17235
661410007660	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
661410007661	5'-3' exonuclease; Region: 53EXOc; smart00475
661410007662	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
661410007663	active site
661410007664	metal binding site 1 [ion binding]; metal-binding site
661410007665	putative 5' ssDNA interaction site; other site
661410007666	metal binding site 3; metal-binding site
661410007667	metal binding site 2 [ion binding]; metal-binding site
661410007668	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
661410007669	putative DNA binding site [nucleotide binding]; other site
661410007670	putative metal binding site [ion binding]; other site
661410007671	DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749
661410007672	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
661410007673	active site
661410007674	catalytic site [active]
661410007675	substrate binding site [chemical binding]; other site
661410007676	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
661410007677	active site
661410007678	DNA binding site [nucleotide binding]
661410007679	catalytic site [active]
661410007680	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
661410007681	Active_site [active]
661410007682	GTP-binding protein YchF; Reviewed; Region: PRK09601
661410007683	YchF GTPase; Region: YchF; cd01900
661410007684	G1 box; other site
661410007685	GTP/Mg2+ binding site [chemical binding]; other site
661410007686	Switch I region; other site
661410007687	G2 box; other site
661410007688	Switch II region; other site
661410007689	G3 box; other site
661410007690	G4 box; other site
661410007691	G5 box; other site
661410007692	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
661410007693	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
661410007694	putative active site [active]
661410007695	catalytic residue [active]
661410007696	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
661410007697	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
661410007698	5S rRNA interface [nucleotide binding]; other site
661410007699	CTC domain interface [polypeptide binding]; other site
661410007700	L16 interface [polypeptide binding]; other site
661410007701	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
661410007702	Flp/Fap pilin component; Region: Flp_Fap; cl01585
661410007703	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
661410007704	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
661410007705	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
661410007706	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
661410007707	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
661410007708	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
661410007709	Type IV pili component [Cell motility and secretion]; Region: COG5461
661410007710	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
661410007711	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
661410007712	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
661410007713	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
661410007714	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
661410007715	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
661410007716	ATP binding site [chemical binding]; other site
661410007717	Walker A motif; other site
661410007718	hexamer interface [polypeptide binding]; other site
661410007719	Walker B motif; other site
661410007720	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
661410007721	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
661410007722	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
661410007723	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
661410007724	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
661410007725	putative active site [active]
661410007726	putative catalytic site [active]
661410007727	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
661410007728	putative active site [active]
661410007729	putative catalytic site [active]
661410007730	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410007731	metabolite-proton symporter; Region: 2A0106; TIGR00883
661410007732	putative substrate translocation pore; other site
661410007733	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
661410007734	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
661410007735	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
661410007736	CoenzymeA binding site [chemical binding]; other site
661410007737	subunit interaction site [polypeptide binding]; other site
661410007738	PHB binding site; other site
661410007739	Major Facilitator Superfamily; Region: MFS_1; pfam07690
661410007740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410007741	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410007742	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410007743	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410007744	metal binding site [ion binding]; metal-binding site
661410007745	active site
661410007746	I-site; other site
661410007747	BA14K-like protein; Region: BA14K; pfam07886
661410007748	CsbD-like; Region: CsbD; pfam05532
661410007749	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
661410007750	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
661410007751	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
661410007752	catalytic site [active]
661410007753	putative active site [active]
661410007754	putative substrate binding site [chemical binding]; other site
661410007755	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
661410007756	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
661410007757	OstA-like protein; Region: OstA; pfam03968
661410007758	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
661410007759	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
661410007760	Walker A/P-loop; other site
661410007761	ATP binding site [chemical binding]; other site
661410007762	Q-loop/lid; other site
661410007763	ABC transporter signature motif; other site
661410007764	Walker B; other site
661410007765	D-loop; other site
661410007766	H-loop/switch region; other site
661410007767	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
661410007768	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
661410007769	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
661410007770	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
661410007771	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
661410007772	30S subunit binding site; other site
661410007773	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
661410007774	active site
661410007775	phosphorylation site [posttranslational modification]
661410007776	magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407
661410007777	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410007778	Walker A motif; other site
661410007779	ATP binding site [chemical binding]; other site
661410007780	Walker B motif; other site
661410007781	arginine finger; other site
661410007782	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
661410007783	catalytic core [active]
661410007784	dihydrodipicolinate reductase; Provisional; Region: PRK00048
661410007785	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
661410007786	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
661410007787	MarC family integral membrane protein; Region: MarC; cl00919
661410007788	Methyltransferase domain; Region: Methyltransf_23; pfam13489
661410007789	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410007790	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
661410007791	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
661410007792	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
661410007793	active site
661410007794	DNA binding site [nucleotide binding]
661410007795	Int/Topo IB signature motif; other site
661410007796	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410007797	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410007798	metal binding site [ion binding]; metal-binding site
661410007799	active site
661410007800	I-site; other site
661410007801	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
661410007802	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
661410007803	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
661410007804	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
661410007805	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410007806	dimer interface [polypeptide binding]; other site
661410007807	conserved gate region; other site
661410007808	ABC-ATPase subunit interface; other site
661410007809	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
661410007810	hypothetical protein; Provisional; Region: PRK08912
661410007811	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
661410007812	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410007813	homodimer interface [polypeptide binding]; other site
661410007814	catalytic residue [active]
661410007815	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410007816	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410007817	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410007818	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
661410007819	Protein export membrane protein; Region: SecD_SecF; cl14618
661410007820	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
661410007821	Protein export membrane protein; Region: SecD_SecF; cl14618
661410007822	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
661410007823	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
661410007824	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
661410007825	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
661410007826	tartrate dehydrogenase; Region: TTC; TIGR02089
661410007827	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
661410007828	benzoylformate decarboxylase; Reviewed; Region: PRK07092
661410007829	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
661410007830	PYR/PP interface [polypeptide binding]; other site
661410007831	dimer interface [polypeptide binding]; other site
661410007832	TPP binding site [chemical binding]; other site
661410007833	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
661410007834	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
661410007835	TPP-binding site [chemical binding]; other site
661410007836	dimer interface [polypeptide binding]; other site
661410007837	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
661410007838	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
661410007839	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
661410007840	substrate binding pocket [chemical binding]; other site
661410007841	chain length determination region; other site
661410007842	substrate-Mg2+ binding site; other site
661410007843	catalytic residues [active]
661410007844	aspartate-rich region 1; other site
661410007845	active site lid residues [active]
661410007846	aspartate-rich region 2; other site
661410007847	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
661410007848	Transglycosylase; Region: Transgly; cl17702
661410007849	photolyase PhrII; Region: phr2; TIGR00591
661410007850	DNA photolyase; Region: DNA_photolyase; pfam00875
661410007851	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
661410007852	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
661410007853	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
661410007854	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
661410007855	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
661410007856	dimerization interface [polypeptide binding]; other site
661410007857	ligand binding site [chemical binding]; other site
661410007858	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
661410007859	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
661410007860	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
661410007861	Sulfatase; Region: Sulfatase; cl17466
661410007862	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
661410007863	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
661410007864	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
661410007865	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410007866	NAD(P) binding site [chemical binding]; other site
661410007867	active site
661410007868	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
661410007869	active site
661410007870	cosubstrate binding site; other site
661410007871	substrate binding site [chemical binding]; other site
661410007872	catalytic site [active]
661410007873	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
661410007874	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
661410007875	homodimer interface [polypeptide binding]; other site
661410007876	substrate-cofactor binding pocket; other site
661410007877	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410007878	catalytic residue [active]
661410007879	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
661410007880	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
661410007881	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
661410007882	[2Fe-2S] cluster binding site [ion binding]; other site
661410007883	cytochrome b; Provisional; Region: CYTB; MTH00191
661410007884	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
661410007885	Qi binding site; other site
661410007886	intrachain domain interface; other site
661410007887	interchain domain interface [polypeptide binding]; other site
661410007888	heme bH binding site [chemical binding]; other site
661410007889	heme bL binding site [chemical binding]; other site
661410007890	Qo binding site; other site
661410007891	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
661410007892	interchain domain interface [polypeptide binding]; other site
661410007893	intrachain domain interface; other site
661410007894	Qi binding site; other site
661410007895	Qo binding site; other site
661410007896	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
661410007897	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
661410007898	Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396
661410007899	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
661410007900	active site
661410007901	metal binding site [ion binding]; metal-binding site
661410007902	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
661410007903	putative active site pocket [active]
661410007904	4-fold oligomerization interface [polypeptide binding]; other site
661410007905	metal binding residues [ion binding]; metal-binding site
661410007906	3-fold/trimer interface [polypeptide binding]; other site
661410007907	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
661410007908	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
661410007909	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
661410007910	putative active site [active]
661410007911	oxyanion strand; other site
661410007912	catalytic triad [active]
661410007913	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
661410007914	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
661410007915	catalytic residues [active]
661410007916	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
661410007917	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
661410007918	substrate binding site [chemical binding]; other site
661410007919	glutamase interaction surface [polypeptide binding]; other site
661410007920	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
661410007921	metal binding site [ion binding]; metal-binding site
661410007922	pantothenate kinase; Provisional; Region: PRK05439
661410007923	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
661410007924	ATP-binding site [chemical binding]; other site
661410007925	CoA-binding site [chemical binding]; other site
661410007926	Mg2+-binding site [ion binding]; other site
661410007927	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410007928	dimerization interface [polypeptide binding]; other site
661410007929	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410007930	dimer interface [polypeptide binding]; other site
661410007931	putative CheW interface [polypeptide binding]; other site
661410007932	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
661410007933	N-acetyl-D-glucosamine binding site [chemical binding]; other site
661410007934	catalytic residue [active]
661410007935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410007936	Response regulator receiver domain; Region: Response_reg; pfam00072
661410007937	active site
661410007938	phosphorylation site [posttranslational modification]
661410007939	intermolecular recognition site; other site
661410007940	dimerization interface [polypeptide binding]; other site
661410007941	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
661410007942	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410007943	Phasin protein; Region: Phasin_2; cl11491
661410007944	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
661410007945	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
661410007946	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410007947	putative active site [active]
661410007948	heme pocket [chemical binding]; other site
661410007949	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410007950	dimer interface [polypeptide binding]; other site
661410007951	phosphorylation site [posttranslational modification]
661410007952	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410007953	ATP binding site [chemical binding]; other site
661410007954	Mg2+ binding site [ion binding]; other site
661410007955	G-X-G motif; other site
661410007956	acetyl-CoA synthetase; Provisional; Region: PRK00174
661410007957	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
661410007958	active site
661410007959	CoA binding site [chemical binding]; other site
661410007960	acyl-activating enzyme (AAE) consensus motif; other site
661410007961	AMP binding site [chemical binding]; other site
661410007962	acetate binding site [chemical binding]; other site
661410007963	Protein of unknown function, DUF485; Region: DUF485; pfam04341
661410007964	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
661410007965	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
661410007966	Na binding site [ion binding]; other site
661410007967	metabolite-proton symporter; Region: 2A0106; TIGR00883
661410007968	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
661410007969	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
661410007970	purine monophosphate binding site [chemical binding]; other site
661410007971	dimer interface [polypeptide binding]; other site
661410007972	putative catalytic residues [active]
661410007973	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
661410007974	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
661410007975	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
661410007976	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
661410007977	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
661410007978	active site residue [active]
661410007979	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
661410007980	active site residue [active]
661410007981	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
661410007982	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
661410007983	DEAD-like helicases superfamily; Region: DEXDc; smart00487
661410007984	ATP binding site [chemical binding]; other site
661410007985	Mg++ binding site [ion binding]; other site
661410007986	motif III; other site
661410007987	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
661410007988	nucleotide binding region [chemical binding]; other site
661410007989	ATP-binding site [chemical binding]; other site
661410007990	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
661410007991	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
661410007992	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
661410007993	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
661410007994	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410007995	Mg2+ binding site [ion binding]; other site
661410007996	G-X-G motif; other site
661410007997	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
661410007998	anchoring element; other site
661410007999	dimer interface [polypeptide binding]; other site
661410008000	ATP binding site [chemical binding]; other site
661410008001	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
661410008002	active site
661410008003	putative metal-binding site [ion binding]; other site
661410008004	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
661410008005	RNA polymerase sigma factor; Provisional; Region: PRK12547
661410008006	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
661410008007	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
661410008008	DNA binding residues [nucleotide binding]
661410008009	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
661410008010	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
661410008011	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
661410008012	aspartate aminotransferase; Provisional; Region: PRK05764
661410008013	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
661410008014	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410008015	homodimer interface [polypeptide binding]; other site
661410008016	catalytic residue [active]
661410008017	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410008018	HAMP domain; Region: HAMP; pfam00672
661410008019	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410008020	dimer interface [polypeptide binding]; other site
661410008021	phosphorylation site [posttranslational modification]
661410008022	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410008023	ATP binding site [chemical binding]; other site
661410008024	Mg2+ binding site [ion binding]; other site
661410008025	G-X-G motif; other site
661410008026	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
661410008027	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410008028	active site
661410008029	phosphorylation site [posttranslational modification]
661410008030	intermolecular recognition site; other site
661410008031	dimerization interface [polypeptide binding]; other site
661410008032	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410008033	DNA binding site [nucleotide binding]
661410008034	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
661410008035	MarR family; Region: MarR_2; pfam12802
661410008036	branched-chain amino acid aminotransferase; Validated; Region: PRK07544
661410008037	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
661410008038	homodimer interface [polypeptide binding]; other site
661410008039	substrate-cofactor binding pocket; other site
661410008040	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410008041	catalytic residue [active]
661410008042	Protein of unknown function (DUF3072); Region: DUF3072; pfam11272
661410008043	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
661410008044	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
661410008045	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
661410008046	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
661410008047	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
661410008048	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
661410008049	TrkA-N domain; Region: TrkA_N; pfam02254
661410008050	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
661410008051	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
661410008052	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
661410008053	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
661410008054	putative active site [active]
661410008055	putative substrate binding site [chemical binding]; other site
661410008056	ATP binding site [chemical binding]; other site
661410008057	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
661410008058	catalytic triad [active]
661410008059	dimer interface [polypeptide binding]; other site
661410008060	hypothetical protein; Validated; Region: PRK00228
661410008061	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
661410008062	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
661410008063	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
661410008064	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
661410008065	motif 1; other site
661410008066	active site
661410008067	motif 2; other site
661410008068	motif 3; other site
661410008069	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
661410008070	Predicted transcriptional regulator [Transcription]; Region: COG2378
661410008071	HTH domain; Region: HTH_11; pfam08279
661410008072	WYL domain; Region: WYL; pfam13280
661410008073	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
661410008074	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
661410008075	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
661410008076	dimer interface [polypeptide binding]; other site
661410008077	N-terminal domain interface [polypeptide binding]; other site
661410008078	putative substrate binding pocket (H-site) [chemical binding]; other site
661410008079	recombinase A; Provisional; Region: recA; PRK09354
661410008080	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
661410008081	hexamer interface [polypeptide binding]; other site
661410008082	Walker A motif; other site
661410008083	ATP binding site [chemical binding]; other site
661410008084	Walker B motif; other site
661410008085	PAS domain; Region: PAS_9; pfam13426
661410008086	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
661410008087	PAS domain; Region: PAS_8; pfam13188
661410008088	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
661410008089	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410008090	dimer interface [polypeptide binding]; other site
661410008091	phosphorylation site [posttranslational modification]
661410008092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410008093	ATP binding site [chemical binding]; other site
661410008094	Mg2+ binding site [ion binding]; other site
661410008095	G-X-G motif; other site
661410008096	Response regulator receiver domain; Region: Response_reg; pfam00072
661410008097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410008098	active site
661410008099	phosphorylation site [posttranslational modification]
661410008100	intermolecular recognition site; other site
661410008101	dimerization interface [polypeptide binding]; other site
661410008102	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
661410008103	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
661410008104	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
661410008105	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
661410008106	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
661410008107	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
661410008108	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
661410008109	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
661410008110	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004
661410008111	Predicted dehydrogenase [General function prediction only]; Region: COG0579
661410008112	hydroxyglutarate oxidase; Provisional; Region: PRK11728
661410008113	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
661410008114	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
661410008115	heme exporter protein CcmC; Region: ccmC; TIGR01191
661410008116	Heme exporter protein D (CcmD); Region: CcmD; pfam04995
661410008117	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
661410008118	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
661410008119	catalytic residues [active]
661410008120	central insert; other site
661410008121	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
661410008122	Cysteine-rich domain; Region: CCG; pfam02754
661410008123	Cysteine-rich domain; Region: CCG; pfam02754
661410008124	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
661410008125	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
661410008126	4Fe-4S binding domain; Region: Fer4; pfam00037
661410008127	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
661410008128	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
661410008129	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
661410008130	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
661410008131	23S rRNA interface [nucleotide binding]; other site
661410008132	L3 interface [polypeptide binding]; other site
661410008133	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
661410008134	Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056
661410008135	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
661410008136	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
661410008137	active site
661410008138	catalytic residues [active]
661410008139	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
661410008140	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410008141	Walker A/P-loop; other site
661410008142	ATP binding site [chemical binding]; other site
661410008143	Q-loop/lid; other site
661410008144	ABC transporter signature motif; other site
661410008145	Walker B; other site
661410008146	D-loop; other site
661410008147	H-loop/switch region; other site
661410008148	Domain of unknown function (DUF329); Region: DUF329; cl01144
661410008149	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
661410008150	active site
661410008151	dimer interface [polypeptide binding]; other site
661410008152	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
661410008153	active site
661410008154	DNA binding site [nucleotide binding]
661410008155	Int/Topo IB signature motif; other site
661410008156	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
661410008157	active site
661410008158	Int/Topo IB signature motif; other site
661410008159	catalytic residues [active]
661410008160	DNA binding site [nucleotide binding]
661410008161	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
661410008162	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
661410008163	N-terminal plug; other site
661410008164	ligand-binding site [chemical binding]; other site
661410008165	heme exporter protein CcmB; Region: ccmB; TIGR01190
661410008166	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
661410008167	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410008168	Walker A/P-loop; other site
661410008169	ATP binding site [chemical binding]; other site
661410008170	Q-loop/lid; other site
661410008171	ABC transporter signature motif; other site
661410008172	Walker B; other site
661410008173	D-loop; other site
661410008174	H-loop/switch region; other site
661410008175	aconitate hydratase; Validated; Region: PRK09277
661410008176	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
661410008177	substrate binding site [chemical binding]; other site
661410008178	ligand binding site [chemical binding]; other site
661410008179	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
661410008180	substrate binding site [chemical binding]; other site
661410008181	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
661410008182	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
661410008183	maleylacetoacetate isomerase; Region: maiA; TIGR01262
661410008184	C-terminal domain interface [polypeptide binding]; other site
661410008185	GSH binding site (G-site) [chemical binding]; other site
661410008186	putative dimer interface [polypeptide binding]; other site
661410008187	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
661410008188	dimer interface [polypeptide binding]; other site
661410008189	N-terminal domain interface [polypeptide binding]; other site
661410008190	substrate binding pocket (H-site) [chemical binding]; other site
661410008191	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
661410008192	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
661410008193	EthD domain; Region: EthD; cl17553
661410008194	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
661410008195	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410008196	dimer interface [polypeptide binding]; other site
661410008197	putative CheW interface [polypeptide binding]; other site
661410008198	quinolinate synthetase; Provisional; Region: PRK09375
661410008199	L-aspartate oxidase; Provisional; Region: PRK07512
661410008200	L-aspartate oxidase; Provisional; Region: PRK06175
661410008201	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
661410008202	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
661410008203	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
661410008204	dimerization interface [polypeptide binding]; other site
661410008205	active site
661410008206	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
661410008207	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410008208	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
661410008209	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
661410008210	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
661410008211	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410008212	FeS/SAM binding site; other site
661410008213	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
661410008214	GSCFA family; Region: GSCFA; pfam08885
661410008215	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
661410008216	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
661410008217	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
661410008218	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
661410008219	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
661410008220	Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; Region: HAD-SF-IB; TIGR01488
661410008221	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
661410008222	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
661410008223	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
661410008224	protein binding site [polypeptide binding]; other site
661410008225	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
661410008226	protein binding site [polypeptide binding]; other site
661410008227	HflC protein; Region: hflC; TIGR01932
661410008228	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
661410008229	HflK protein; Region: hflK; TIGR01933
661410008230	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
661410008231	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
661410008232	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
661410008233	folate binding site [chemical binding]; other site
661410008234	NADP+ binding site [chemical binding]; other site
661410008235	thymidylate synthase; Reviewed; Region: thyA; PRK01827
661410008236	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
661410008237	dimerization interface [polypeptide binding]; other site
661410008238	active site
661410008239	CAAX protease self-immunity; Region: Abi; pfam02517
661410008240	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
661410008241	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
661410008242	Cytochrome P450; Region: p450; cl12078
661410008243	fumarate hydratase; Reviewed; Region: fumC; PRK00485
661410008244	Class II fumarases; Region: Fumarase_classII; cd01362
661410008245	active site
661410008246	tetramer interface [polypeptide binding]; other site
661410008247	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
661410008248	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
661410008249	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
661410008250	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
661410008251	cobalamin binding residues [chemical binding]; other site
661410008252	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
661410008253	putative BtuC binding residues; other site
661410008254	dimer interface [polypeptide binding]; other site
661410008255	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
661410008256	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
661410008257	pyridoxamine kinase; Validated; Region: PRK05756
661410008258	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
661410008259	dimer interface [polypeptide binding]; other site
661410008260	pyridoxal binding site [chemical binding]; other site
661410008261	ATP binding site [chemical binding]; other site
661410008262	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
661410008263	2-isopropylmalate synthase; Validated; Region: PRK00915
661410008264	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
661410008265	active site
661410008266	catalytic residues [active]
661410008267	metal binding site [ion binding]; metal-binding site
661410008268	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
661410008269	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
661410008270	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
661410008271	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
661410008272	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
661410008273	active site
661410008274	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
661410008275	N-acetyl-D-glucosamine binding site [chemical binding]; other site
661410008276	catalytic residue [active]
661410008277	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994
661410008278	HD domain; Region: HD_3; cl17350
661410008279	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410008280	Methyltransferase domain; Region: Methyltransf_23; pfam13489
661410008281	S-adenosylmethionine binding site [chemical binding]; other site
661410008282	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
661410008283	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
661410008284	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
661410008285	putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266
661410008286	YcaO-like family; Region: YcaO; pfam02624
661410008287	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
661410008288	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
661410008289	DNA interaction; other site
661410008290	Metal-binding active site; metal-binding site
661410008291	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410008292	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
661410008293	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
661410008294	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035
661410008295	putative uracil binding site [chemical binding]; other site
661410008296	putative active site [active]
661410008297	Predicted integral membrane protein [Function unknown]; Region: COG0392
661410008298	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
661410008299	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410008300	putative active site [active]
661410008301	heme pocket [chemical binding]; other site
661410008302	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410008303	dimer interface [polypeptide binding]; other site
661410008304	phosphorylation site [posttranslational modification]
661410008305	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410008306	ATP binding site [chemical binding]; other site
661410008307	Mg2+ binding site [ion binding]; other site
661410008308	G-X-G motif; other site
661410008309	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
661410008310	metal-binding site [ion binding]
661410008311	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
661410008312	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
661410008313	metal-binding site [ion binding]
661410008314	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
661410008315	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
661410008316	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
661410008317	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
661410008318	DNA binding residues [nucleotide binding]
661410008319	dimer interface [polypeptide binding]; other site
661410008320	copper binding site [ion binding]; other site
661410008321	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
661410008322	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
661410008323	metal binding site [ion binding]; metal-binding site
661410008324	putative dimer interface [polypeptide binding]; other site
661410008325	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
661410008326	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
661410008327	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
661410008328	RNA binding site [nucleotide binding]; other site
661410008329	active site
661410008330	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
661410008331	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
661410008332	translation initiation factor IF-2; Region: IF-2; TIGR00487
661410008333	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
661410008334	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
661410008335	G1 box; other site
661410008336	putative GEF interaction site [polypeptide binding]; other site
661410008337	GTP/Mg2+ binding site [chemical binding]; other site
661410008338	Switch I region; other site
661410008339	G2 box; other site
661410008340	G3 box; other site
661410008341	Switch II region; other site
661410008342	G4 box; other site
661410008343	G5 box; other site
661410008344	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
661410008345	Translation-initiation factor 2; Region: IF-2; pfam11987
661410008346	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
661410008347	hypothetical protein; Provisional; Region: PRK09190
661410008348	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
661410008349	putative RNA binding cleft [nucleotide binding]; other site
661410008350	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
661410008351	NusA N-terminal domain; Region: NusA_N; pfam08529
661410008352	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
661410008353	RNA binding site [nucleotide binding]; other site
661410008354	homodimer interface [polypeptide binding]; other site
661410008355	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
661410008356	G-X-X-G motif; other site
661410008357	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
661410008358	G-X-X-G motif; other site
661410008359	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
661410008360	ribosome maturation protein RimP; Reviewed; Region: PRK00092
661410008361	Sm and related proteins; Region: Sm_like; cl00259
661410008362	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
661410008363	putative oligomer interface [polypeptide binding]; other site
661410008364	putative RNA binding site [nucleotide binding]; other site
661410008365	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
661410008366	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
661410008367	trimer interface [polypeptide binding]; other site
661410008368	active site
661410008369	substrate binding site [chemical binding]; other site
661410008370	CoA binding site [chemical binding]; other site
661410008371	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
661410008372	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
661410008373	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
661410008374	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
661410008375	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
661410008376	Coenzyme A binding pocket [chemical binding]; other site
661410008377	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
661410008378	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
661410008379	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
661410008380	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
661410008381	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
661410008382	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
661410008383	WHG domain; Region: WHG; pfam13305
661410008384	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
661410008385	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
661410008386	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
661410008387	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
661410008388	catalytic site [active]
661410008389	active site
661410008390	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
661410008391	putative bifunctional 4-alpha-glucanotransferase/malto-oligosyltrehalose synthase; Provisional; Region: PRK14507
661410008392	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
661410008393	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
661410008394	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
661410008395	active site
661410008396	catalytic site [active]
661410008397	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
661410008398	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
661410008399	active site
661410008400	catalytic site [active]
661410008401	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
661410008402	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
661410008403	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
661410008404	active site
661410008405	homodimer interface [polypeptide binding]; other site
661410008406	catalytic site [active]
661410008407	acceptor binding site [chemical binding]; other site
661410008408	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
661410008409	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
661410008410	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410008411	FeS/SAM binding site; other site
661410008412	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
661410008413	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
661410008414	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
661410008415	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
661410008416	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
661410008417	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
661410008418	minor groove reading motif; other site
661410008419	helix-hairpin-helix signature motif; other site
661410008420	substrate binding pocket [chemical binding]; other site
661410008421	active site
661410008422	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
661410008423	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410008424	FeS/SAM binding site; other site
661410008425	hypothetical protein; Provisional; Region: PRK02237
661410008426	glycogen branching enzyme; Provisional; Region: PRK05402
661410008427	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
661410008428	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
661410008429	active site
661410008430	catalytic site [active]
661410008431	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
661410008432	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
661410008433	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
661410008434	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
661410008435	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
661410008436	active site
661410008437	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
661410008438	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
661410008439	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
661410008440	P loop; other site
661410008441	GTP binding site [chemical binding]; other site
661410008442	intracellular septation protein A; Reviewed; Region: PRK00259
661410008443	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
661410008444	phytoene desaturase; Region: crtI_fam; TIGR02734
661410008445	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
661410008446	substrate binding pocket [chemical binding]; other site
661410008447	chain length determination region; other site
661410008448	substrate-Mg2+ binding site; other site
661410008449	catalytic residues [active]
661410008450	aspartate-rich region 1; other site
661410008451	active site lid residues [active]
661410008452	aspartate-rich region 2; other site
661410008453	O-methyltransferase; Region: Methyltransf_2; pfam00891
661410008454	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
661410008455	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
661410008456	putative NAD(P) binding site [chemical binding]; other site
661410008457	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
661410008458	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
661410008459	Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY).  Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980
661410008460	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
661410008461	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
661410008462	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
661410008463	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
661410008464	Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290
661410008465	subunit M interface; other site
661410008466	subunit H interface; other site
661410008467	quinone binding site; other site
661410008468	bacteriopheophytin binding site; other site
661410008469	bacteriochlorophyll binding site; other site
661410008470	cytochrome C subunit interface; other site
661410008471	Fe binding site [ion binding]; other site
661410008472	Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291
661410008473	subunit H interface; other site
661410008474	subunit L interface; other site
661410008475	bacteriopheophytin binding site; other site
661410008476	carotenoid binding site; other site
661410008477	bacteriochlorophyll binding site; other site
661410008478	cytochrome C interface; other site
661410008479	quinone binding site; other site
661410008480	Fe binding site [ion binding]; other site
661410008481	Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cd09224
661410008482	subunit interface [polypeptide binding]; other site
661410008483	Heme binding sites [chemical binding]; other site
661410008484	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
661410008485	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
661410008486	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
661410008487	Walker A/P-loop; other site
661410008488	ATP binding site [chemical binding]; other site
661410008489	Q-loop/lid; other site
661410008490	ABC transporter signature motif; other site
661410008491	Walker B; other site
661410008492	D-loop; other site
661410008493	H-loop/switch region; other site
661410008494	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
661410008495	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410008496	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410008497	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
661410008498	TPR repeat; Region: TPR_11; pfam13414
661410008499	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
661410008500	TPR motif; other site
661410008501	TPR repeat; Region: TPR_11; pfam13414
661410008502	binding surface
661410008503	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
661410008504	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
661410008505	catalytic site [active]
661410008506	pyruvate kinase; Provisional; Region: PRK06247
661410008507	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
661410008508	domain interfaces; other site
661410008509	active site
661410008510	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
661410008511	Protein of unknown function (DUF1036); Region: DUF1036; pfam06282
661410008512	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
661410008513	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
661410008514	MOFRL family; Region: MOFRL; pfam05161
661410008515	N-formylglutamate amidohydrolase; Region: FGase; cl01522
661410008516	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
661410008517	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
661410008518	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
661410008519	Peptidase M15; Region: Peptidase_M15_3; cl01194
661410008520	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
661410008521	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410008522	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410008523	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
661410008524	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410008525	active site
661410008526	phosphorylation site [posttranslational modification]
661410008527	intermolecular recognition site; other site
661410008528	dimerization interface [polypeptide binding]; other site
661410008529	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410008530	Walker A motif; other site
661410008531	ATP binding site [chemical binding]; other site
661410008532	Walker B motif; other site
661410008533	arginine finger; other site
661410008534	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
661410008535	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
661410008536	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
661410008537	active site
661410008538	Zn binding site [ion binding]; other site
661410008539	putative addiction module antidote; Region: doc_partner; TIGR02609
661410008540	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
661410008541	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
661410008542	ABC1 family; Region: ABC1; cl17513
661410008543	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
661410008544	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
661410008545	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
661410008546	ligand binding site [chemical binding]; other site
661410008547	homodimer interface [polypeptide binding]; other site
661410008548	NAD(P) binding site [chemical binding]; other site
661410008549	trimer interface B [polypeptide binding]; other site
661410008550	trimer interface A [polypeptide binding]; other site
661410008551	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
661410008552	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
661410008553	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
661410008554	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
661410008555	DHH family; Region: DHH; pfam01368
661410008556	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410008557	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410008558	ligand binding site [chemical binding]; other site
661410008559	flexible hinge region; other site
661410008560	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
661410008561	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410008562	HWE histidine kinase; Region: HWE_HK; smart00911
661410008563	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
661410008564	Surface antigen; Region: Bac_surface_Ag; pfam01103
661410008565	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
661410008566	Family of unknown function (DUF490); Region: DUF490; pfam04357
661410008567	cyanate hydratase; Validated; Region: PRK02866
661410008568	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
661410008569	oligomer interface [polypeptide binding]; other site
661410008570	active site
661410008571	PAS domain S-box; Region: sensory_box; TIGR00229
661410008572	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410008573	putative active site [active]
661410008574	heme pocket [chemical binding]; other site
661410008575	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410008576	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
661410008577	Walker A motif; other site
661410008578	ATP binding site [chemical binding]; other site
661410008579	Walker B motif; other site
661410008580	arginine finger; other site
661410008581	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
661410008582	tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791
661410008583	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
661410008584	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
661410008585	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
661410008586	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410008587	dimerization interface [polypeptide binding]; other site
661410008588	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410008589	PAS fold; Region: PAS_7; pfam12860
661410008590	putative active site [active]
661410008591	heme pocket [chemical binding]; other site
661410008592	PAS domain; Region: PAS; smart00091
661410008593	PAS fold; Region: PAS_7; pfam12860
661410008594	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410008595	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410008596	metal binding site [ion binding]; metal-binding site
661410008597	active site
661410008598	I-site; other site
661410008599	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410008600	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
661410008601	dimanganese center [ion binding]; other site
661410008602	Domain of unknown function (DUF892); Region: DUF892; pfam05974
661410008603	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
661410008604	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
661410008605	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
661410008606	Cl- selectivity filter; other site
661410008607	Cl- binding residues [ion binding]; other site
661410008608	pore gating glutamate residue; other site
661410008609	dimer interface [polypeptide binding]; other site
661410008610	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
661410008611	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
661410008612	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
661410008613	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
661410008614	enolase; Provisional; Region: eno; PRK00077
661410008615	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
661410008616	dimer interface [polypeptide binding]; other site
661410008617	metal binding site [ion binding]; metal-binding site
661410008618	substrate binding pocket [chemical binding]; other site
661410008619	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
661410008620	Septum formation initiator; Region: DivIC; cl17659
661410008621	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
661410008622	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
661410008623	tetramer interface [polypeptide binding]; other site
661410008624	TPP-binding site [chemical binding]; other site
661410008625	heterodimer interface [polypeptide binding]; other site
661410008626	phosphorylation loop region [posttranslational modification]
661410008627	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
661410008628	E3 interaction surface; other site
661410008629	lipoyl attachment site [posttranslational modification]; other site
661410008630	pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212
661410008631	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
661410008632	alpha subunit interface [polypeptide binding]; other site
661410008633	TPP binding site [chemical binding]; other site
661410008634	heterodimer interface [polypeptide binding]; other site
661410008635	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
661410008636	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
661410008637	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
661410008638	E3 interaction surface; other site
661410008639	lipoyl attachment site [posttranslational modification]; other site
661410008640	e3 binding domain; Region: E3_binding; pfam02817
661410008641	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
661410008642	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
661410008643	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
661410008644	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
661410008645	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
661410008646	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
661410008647	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410008648	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
661410008649	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
661410008650	lipoyl synthase; Provisional; Region: PRK05481
661410008651	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410008652	FeS/SAM binding site; other site
661410008653	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
661410008654	putative coenzyme Q binding site [chemical binding]; other site
661410008655	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
661410008656	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
661410008657	putative DNA binding site [nucleotide binding]; other site
661410008658	putative Zn2+ binding site [ion binding]; other site
661410008659	AsnC family; Region: AsnC_trans_reg; pfam01037
661410008660	ornithine cyclodeaminase; Validated; Region: PRK07589
661410008661	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
661410008662	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
661410008663	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
661410008664	dimer interface [polypeptide binding]; other site
661410008665	active site
661410008666	CoA binding pocket [chemical binding]; other site
661410008667	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
661410008668	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
661410008669	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
661410008670	dimer interface [polypeptide binding]; other site
661410008671	active site
661410008672	CoA binding pocket [chemical binding]; other site
661410008673	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
661410008674	classical (c) SDRs; Region: SDR_c; cd05233
661410008675	NAD(P) binding site [chemical binding]; other site
661410008676	active site
661410008677	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
661410008678	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
661410008679	iron-sulfur cluster [ion binding]; other site
661410008680	[2Fe-2S] cluster binding site [ion binding]; other site
661410008681	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
661410008682	alpha subunit interface [polypeptide binding]; other site
661410008683	active site
661410008684	substrate binding site [chemical binding]; other site
661410008685	Fe binding site [ion binding]; other site
661410008686	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
661410008687	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
661410008688	putative trimer interface [polypeptide binding]; other site
661410008689	putative CoA binding site [chemical binding]; other site
661410008690	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
661410008691	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
661410008692	binding surface
661410008693	TPR motif; other site
661410008694	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
661410008695	binding surface
661410008696	TPR motif; other site
661410008697	TPR repeat; Region: TPR_11; pfam13414
661410008698	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
661410008699	TPR motif; other site
661410008700	binding surface
661410008701	TPR repeat; Region: TPR_11; pfam13414
661410008702	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551
661410008703	active site
661410008704	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
661410008705	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
661410008706	Walker A/P-loop; other site
661410008707	ATP binding site [chemical binding]; other site
661410008708	Q-loop/lid; other site
661410008709	ABC transporter signature motif; other site
661410008710	Walker B; other site
661410008711	D-loop; other site
661410008712	H-loop/switch region; other site
661410008713	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
661410008714	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
661410008715	catalytic loop [active]
661410008716	iron binding site [ion binding]; other site
661410008717	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
661410008718	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
661410008719	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
661410008720	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
661410008721	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
661410008722	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
661410008723	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
661410008724	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
661410008725	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
661410008726	substrate binding site; other site
661410008727	dimer interface; other site
661410008728	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
661410008729	homotrimer interaction site [polypeptide binding]; other site
661410008730	zinc binding site [ion binding]; other site
661410008731	CDP-binding sites; other site
661410008732	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
661410008733	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
661410008734	FMN binding site [chemical binding]; other site
661410008735	active site
661410008736	catalytic residues [active]
661410008737	substrate binding site [chemical binding]; other site
661410008738	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
661410008739	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410008740	dimer interface [polypeptide binding]; other site
661410008741	phosphorylation site [posttranslational modification]
661410008742	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410008743	ATP binding site [chemical binding]; other site
661410008744	Mg2+ binding site [ion binding]; other site
661410008745	G-X-G motif; other site
661410008746	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
661410008747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410008748	active site
661410008749	phosphorylation site [posttranslational modification]
661410008750	intermolecular recognition site; other site
661410008751	dimerization interface [polypeptide binding]; other site
661410008752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410008753	Walker A motif; other site
661410008754	ATP binding site [chemical binding]; other site
661410008755	Walker B motif; other site
661410008756	arginine finger; other site
661410008757	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
661410008758	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
661410008759	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
661410008760	putative Mg++ binding site [ion binding]; other site
661410008761	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
661410008762	nucleotide binding region [chemical binding]; other site
661410008763	ATP-binding site [chemical binding]; other site
661410008764	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
661410008765	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410008766	dimerization interface [polypeptide binding]; other site
661410008767	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410008768	putative active site [active]
661410008769	heme pocket [chemical binding]; other site
661410008770	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410008771	dimer interface [polypeptide binding]; other site
661410008772	phosphorylation site [posttranslational modification]
661410008773	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410008774	ATP binding site [chemical binding]; other site
661410008775	Mg2+ binding site [ion binding]; other site
661410008776	G-X-G motif; other site
661410008777	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
661410008778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410008779	active site
661410008780	phosphorylation site [posttranslational modification]
661410008781	intermolecular recognition site; other site
661410008782	dimerization interface [polypeptide binding]; other site
661410008783	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410008784	Walker A motif; other site
661410008785	ATP binding site [chemical binding]; other site
661410008786	Walker B motif; other site
661410008787	arginine finger; other site
661410008788	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
661410008789	bacterial Hfq-like; Region: Hfq; cd01716
661410008790	hexamer interface [polypeptide binding]; other site
661410008791	Sm1 motif; other site
661410008792	RNA binding site [nucleotide binding]; other site
661410008793	Sm2 motif; other site
661410008794	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
661410008795	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
661410008796	HflX GTPase family; Region: HflX; cd01878
661410008797	G1 box; other site
661410008798	GTP/Mg2+ binding site [chemical binding]; other site
661410008799	Switch I region; other site
661410008800	G2 box; other site
661410008801	G3 box; other site
661410008802	Switch II region; other site
661410008803	G4 box; other site
661410008804	G5 box; other site
661410008805	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
661410008806	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
661410008807	Sulfate transporter family; Region: Sulfate_transp; pfam00916
661410008808	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
661410008809	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
661410008810	active site clefts [active]
661410008811	zinc binding site [ion binding]; other site
661410008812	dimer interface [polypeptide binding]; other site
661410008813	Domain of unknown function (DUF305); Region: DUF305; cl17794
661410008814	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
661410008815	Protein export membrane protein; Region: SecD_SecF; cl14618
661410008816	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
661410008817	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410008818	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
661410008819	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
661410008820	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
661410008821	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
661410008822	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
661410008823	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410008824	dimerization interface [polypeptide binding]; other site
661410008825	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
661410008826	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410008827	dimer interface [polypeptide binding]; other site
661410008828	putative CheW interface [polypeptide binding]; other site
661410008829	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
661410008830	putative binding surface; other site
661410008831	active site
661410008832	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410008833	ATP binding site [chemical binding]; other site
661410008834	Mg2+ binding site [ion binding]; other site
661410008835	G-X-G motif; other site
661410008836	CheW-like domain; Region: CheW; pfam01584
661410008837	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410008838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410008839	active site
661410008840	phosphorylation site [posttranslational modification]
661410008841	intermolecular recognition site; other site
661410008842	dimerization interface [polypeptide binding]; other site
661410008843	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
661410008844	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410008845	active site
661410008846	phosphorylation site [posttranslational modification]
661410008847	intermolecular recognition site; other site
661410008848	dimerization interface [polypeptide binding]; other site
661410008849	CheB methylesterase; Region: CheB_methylest; pfam01339
661410008850	Response regulator receiver domain; Region: Response_reg; pfam00072
661410008851	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410008852	active site
661410008853	phosphorylation site [posttranslational modification]
661410008854	intermolecular recognition site; other site
661410008855	dimerization interface [polypeptide binding]; other site
661410008856	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410008857	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410008858	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410008859	dimer interface [polypeptide binding]; other site
661410008860	phosphorylation site [posttranslational modification]
661410008861	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410008862	ATP binding site [chemical binding]; other site
661410008863	Mg2+ binding site [ion binding]; other site
661410008864	G-X-G motif; other site
661410008865	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410008866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410008867	active site
661410008868	phosphorylation site [posttranslational modification]
661410008869	intermolecular recognition site; other site
661410008870	dimerization interface [polypeptide binding]; other site
661410008871	PAS fold; Region: PAS_4; pfam08448
661410008872	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410008873	dimer interface [polypeptide binding]; other site
661410008874	phosphorylation site [posttranslational modification]
661410008875	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410008876	ATP binding site [chemical binding]; other site
661410008877	Mg2+ binding site [ion binding]; other site
661410008878	G-X-G motif; other site
661410008879	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410008880	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410008881	active site
661410008882	phosphorylation site [posttranslational modification]
661410008883	intermolecular recognition site; other site
661410008884	dimerization interface [polypeptide binding]; other site
661410008885	FOG: WD40 repeat [General function prediction only]; Region: COG2319
661410008886	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
661410008887	structural tetrad; other site
661410008888	Cytochrome c; Region: Cytochrom_C; cl11414
661410008889	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
661410008890	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
661410008891	MPT binding site; other site
661410008892	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
661410008893	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
661410008894	dimer interface [polypeptide binding]; other site
661410008895	putative functional site; other site
661410008896	putative MPT binding site; other site
661410008897	PBP superfamily domain; Region: PBP_like; pfam12727
661410008898	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
661410008899	Walker A motif; other site
661410008900	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
661410008901	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
661410008902	dimer interface [polypeptide binding]; other site
661410008903	putative functional site; other site
661410008904	putative MPT binding site; other site
661410008905	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
661410008906	PBP superfamily domain; Region: PBP_like; pfam12727
661410008907	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410008908	dimer interface [polypeptide binding]; other site
661410008909	conserved gate region; other site
661410008910	putative PBP binding loops; other site
661410008911	ABC-ATPase subunit interface; other site
661410008912	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
661410008913	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
661410008914	Walker A/P-loop; other site
661410008915	ATP binding site [chemical binding]; other site
661410008916	Q-loop/lid; other site
661410008917	ABC transporter signature motif; other site
661410008918	Walker B; other site
661410008919	D-loop; other site
661410008920	H-loop/switch region; other site
661410008921	PBP superfamily domain; Region: PBP_like_2; pfam12849
661410008922	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
661410008923	PRC-barrel domain; Region: PRC; pfam05239
661410008924	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
661410008925	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
661410008926	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
661410008927	Ligand binding site; other site
661410008928	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
661410008929	DXD motif; other site
661410008930	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
661410008931	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
661410008932	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
661410008933	catalytic residue [active]
661410008934	TspO/MBR family; Region: TspO_MBR; pfam03073
661410008935	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410008936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410008937	active site
661410008938	phosphorylation site [posttranslational modification]
661410008939	intermolecular recognition site; other site
661410008940	dimerization interface [polypeptide binding]; other site
661410008941	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
661410008942	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
661410008943	active site
661410008944	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
661410008945	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
661410008946	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
661410008947	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
661410008948	Walker A/P-loop; other site
661410008949	ATP binding site [chemical binding]; other site
661410008950	Q-loop/lid; other site
661410008951	ABC transporter signature motif; other site
661410008952	Walker B; other site
661410008953	D-loop; other site
661410008954	H-loop/switch region; other site
661410008955	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
661410008956	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
661410008957	Uncharacterized conserved protein [Function unknown]; Region: COG1434
661410008958	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
661410008959	putative active site [active]
661410008960	Response regulator receiver domain; Region: Response_reg; pfam00072
661410008961	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410008962	active site
661410008963	phosphorylation site [posttranslational modification]
661410008964	intermolecular recognition site; other site
661410008965	dimerization interface [polypeptide binding]; other site
661410008966	gamma-glutamyl kinase; Provisional; Region: PRK05429
661410008967	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
661410008968	nucleotide binding site [chemical binding]; other site
661410008969	homotetrameric interface [polypeptide binding]; other site
661410008970	putative phosphate binding site [ion binding]; other site
661410008971	putative allosteric binding site; other site
661410008972	PUA domain; Region: PUA; pfam01472
661410008973	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
661410008974	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
661410008975	putative catalytic cysteine [active]
661410008976	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
661410008977	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
661410008978	active site
661410008979	(T/H)XGH motif; other site
661410008980	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
661410008981	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
661410008982	Predicted transcriptional regulators [Transcription]; Region: COG1510
661410008983	MarR family; Region: MarR_2; pfam12802
661410008984	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
661410008985	active site
661410008986	catalytic residues [active]
661410008987	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
661410008988	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
661410008989	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410008990	Walker A/P-loop; other site
661410008991	ATP binding site [chemical binding]; other site
661410008992	Q-loop/lid; other site
661410008993	ABC transporter signature motif; other site
661410008994	Walker B; other site
661410008995	D-loop; other site
661410008996	H-loop/switch region; other site
661410008997	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
661410008998	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
661410008999	metal binding site [ion binding]; metal-binding site
661410009000	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
661410009001	MoaE interaction surface [polypeptide binding]; other site
661410009002	MoeB interaction surface [polypeptide binding]; other site
661410009003	thiocarboxylated glycine; other site
661410009004	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
661410009005	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
661410009006	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
661410009007	GIY-YIG motif/motif A; other site
661410009008	active site
661410009009	catalytic site [active]
661410009010	putative DNA binding site [nucleotide binding]; other site
661410009011	metal binding site [ion binding]; metal-binding site
661410009012	UvrB/uvrC motif; Region: UVR; pfam02151
661410009013	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
661410009014	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
661410009015	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
661410009016	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410009017	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
661410009018	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
661410009019	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
661410009020	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
661410009021	Uncharacterized conserved protein [Function unknown]; Region: COG1565
661410009022	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
661410009023	putative Mg(2+) transport ATPase; Provisional; Region: PRK09977
661410009024	MgtC family; Region: MgtC; pfam02308
661410009025	phosphoglucomutase; Region: PLN02307
661410009026	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
661410009027	active site
661410009028	substrate binding site [chemical binding]; other site
661410009029	metal binding site [ion binding]; metal-binding site
661410009030	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
661410009031	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
661410009032	pyruvate phosphate dikinase; Provisional; Region: PRK09279
661410009033	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
661410009034	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
661410009035	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
661410009036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
661410009037	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410009038	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
661410009039	dimer interface [polypeptide binding]; other site
661410009040	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
661410009041	metal binding site [ion binding]; metal-binding site
661410009042	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410009043	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410009044	ligand binding site [chemical binding]; other site
661410009045	flexible hinge region; other site
661410009046	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
661410009047	MarR family; Region: MarR; pfam01047
661410009048	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
661410009049	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
661410009050	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
661410009051	two-component response regulator; Provisional; Region: PRK09191
661410009052	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
661410009053	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410009054	active site
661410009055	phosphorylation site [posttranslational modification]
661410009056	intermolecular recognition site; other site
661410009057	dimerization interface [polypeptide binding]; other site
661410009058	aminotransferase; Provisional; Region: PRK06105
661410009059	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
661410009060	inhibitor-cofactor binding pocket; inhibition site
661410009061	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410009062	catalytic residue [active]
661410009063	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
661410009064	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
661410009065	putative active site [active]
661410009066	putative metal binding site [ion binding]; other site
661410009067	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
661410009068	AlkA N-terminal domain; Region: AlkA_N; pfam06029
661410009069	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
661410009070	minor groove reading motif; other site
661410009071	helix-hairpin-helix signature motif; other site
661410009072	active site
661410009073	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
661410009074	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
661410009075	catalytic site [active]
661410009076	putative active site [active]
661410009077	putative substrate binding site [chemical binding]; other site
661410009078	HRDC domain; Region: HRDC; pfam00570
661410009079	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
661410009080	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
661410009081	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
661410009082	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
661410009083	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
661410009084	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
661410009085	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
661410009086	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
661410009087	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
661410009088	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
661410009089	N-terminal plug; other site
661410009090	ligand-binding site [chemical binding]; other site
661410009091	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
661410009092	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
661410009093	Walker A/P-loop; other site
661410009094	ATP binding site [chemical binding]; other site
661410009095	Q-loop/lid; other site
661410009096	ABC transporter signature motif; other site
661410009097	Walker B; other site
661410009098	D-loop; other site
661410009099	H-loop/switch region; other site
661410009100	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
661410009101	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
661410009102	ABC-ATPase subunit  interface; other site
661410009103	dimer interface [polypeptide binding]; other site
661410009104	putative PBP binding regions; other site
661410009105	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
661410009106	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
661410009107	intersubunit interface [polypeptide binding]; other site
661410009108	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
661410009109	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
661410009110	putative active site [active]
661410009111	GMP synthase; Reviewed; Region: guaA; PRK00074
661410009112	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
661410009113	AMP/PPi binding site [chemical binding]; other site
661410009114	candidate oxyanion hole; other site
661410009115	catalytic triad [active]
661410009116	potential glutamine specificity residues [chemical binding]; other site
661410009117	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
661410009118	ATP Binding subdomain [chemical binding]; other site
661410009119	Ligand Binding sites [chemical binding]; other site
661410009120	Dimerization subdomain; other site
661410009121	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
661410009122	active site
661410009123	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
661410009124	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
661410009125	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
661410009126	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410009127	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
661410009128	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
661410009129	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
661410009130	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
661410009131	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
661410009132	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
661410009133	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
661410009134	active site
661410009135	cell division protein FtsW; Region: ftsW; TIGR02614
661410009136	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
661410009137	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
661410009138	active site
661410009139	homodimer interface [polypeptide binding]; other site
661410009140	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
661410009141	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
661410009142	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
661410009143	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
661410009144	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
661410009145	salt bridge; other site
661410009146	non-specific DNA binding site [nucleotide binding]; other site
661410009147	sequence-specific DNA binding site [nucleotide binding]; other site
661410009148	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
661410009149	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
661410009150	FAD binding domain; Region: FAD_binding_4; pfam01565
661410009151	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
661410009152	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
661410009153	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
661410009154	ATP-grasp domain; Region: ATP-grasp_4; cl17255
661410009155	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
661410009156	Cell division protein FtsQ; Region: FtsQ; pfam03799
661410009157	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
661410009158	Cell division protein FtsA; Region: FtsA; smart00842
661410009159	Cell division protein FtsA; Region: FtsA; pfam14450
661410009160	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
661410009161	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
661410009162	nucleotide binding site [chemical binding]; other site
661410009163	SulA interaction site; other site
661410009164	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
661410009165	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
661410009166	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
661410009167	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
661410009168	active site
661410009169	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
661410009170	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
661410009171	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
661410009172	Walker A/P-loop; other site
661410009173	ATP binding site [chemical binding]; other site
661410009174	Q-loop/lid; other site
661410009175	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
661410009176	ABC transporter signature motif; other site
661410009177	Walker B; other site
661410009178	D-loop; other site
661410009179	H-loop/switch region; other site
661410009180	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
661410009181	yiaA/B two helix domain; Region: YiaAB; cl01759
661410009182	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
661410009183	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
661410009184	putative molybdopterin cofactor binding site [chemical binding]; other site
661410009185	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
661410009186	putative molybdopterin cofactor binding site; other site
661410009187	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
661410009188	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
661410009189	nucleotide binding site [chemical binding]; other site
661410009190	NEF interaction site [polypeptide binding]; other site
661410009191	SBD interface [polypeptide binding]; other site
661410009192	chaperone protein DnaJ; Provisional; Region: PRK10767
661410009193	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
661410009194	HSP70 interaction site [polypeptide binding]; other site
661410009195	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
661410009196	substrate binding site [polypeptide binding]; other site
661410009197	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
661410009198	Zn binding sites [ion binding]; other site
661410009199	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
661410009200	dimer interface [polypeptide binding]; other site
661410009201	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410009202	S-adenosylmethionine binding site [chemical binding]; other site
661410009203	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
661410009204	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
661410009205	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
661410009206	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
661410009207	intersubunit interface [polypeptide binding]; other site
661410009208	active site
661410009209	catalytic residue [active]
661410009210	purine nucleoside phosphorylase; Provisional; Region: PRK08202
661410009211	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
661410009212	active site
661410009213	catalytic motif [active]
661410009214	Zn binding site [ion binding]; other site
661410009215	Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; pfam09866
661410009216	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
661410009217	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
661410009218	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
661410009219	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
661410009220	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
661410009221	putative acyl-acceptor binding pocket; other site
661410009222	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
661410009223	active site
661410009224	metal binding site [ion binding]; metal-binding site
661410009225	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
661410009226	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
661410009227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410009228	active site
661410009229	phosphorylation site [posttranslational modification]
661410009230	intermolecular recognition site; other site
661410009231	dimerization interface [polypeptide binding]; other site
661410009232	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
661410009233	DNA-binding site [nucleotide binding]; DNA binding site
661410009234	RNA-binding motif; other site
661410009235	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
661410009236	DNA-binding site [nucleotide binding]; DNA binding site
661410009237	RNA-binding motif; other site
661410009238	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
661410009239	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
661410009240	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
661410009241	interface (dimer of trimers) [polypeptide binding]; other site
661410009242	Substrate-binding/catalytic site; other site
661410009243	Zn-binding sites [ion binding]; other site
661410009244	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
661410009245	TPR motif; other site
661410009246	binding surface
661410009247	TPR repeat; Region: TPR_11; pfam13414
661410009248	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
661410009249	binding surface
661410009250	TPR motif; other site
661410009251	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
661410009252	Predicted permeases [General function prediction only]; Region: COG0679
661410009253	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
661410009254	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
661410009255	active site
661410009256	nucleotide binding site [chemical binding]; other site
661410009257	HIGH motif; other site
661410009258	KMSKS motif; other site
661410009259	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
661410009260	peptide chain release factor 2; Provisional; Region: PRK07342
661410009261	This domain is found in peptide chain release factors; Region: PCRF; smart00937
661410009262	RF-1 domain; Region: RF-1; pfam00472
661410009263	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
661410009264	Peptidase family M23; Region: Peptidase_M23; pfam01551
661410009265	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
661410009266	catalytic triad [active]
661410009267	Protein of unknown function; Region: DUF3971; pfam13116
661410009268	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
661410009269	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
661410009270	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
661410009271	putative di-iron ligands [ion binding]; other site
661410009272	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
661410009273	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
661410009274	active site
661410009275	HIGH motif; other site
661410009276	dimer interface [polypeptide binding]; other site
661410009277	KMSKS motif; other site
661410009278	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
661410009279	RNA binding surface [nucleotide binding]; other site
661410009280	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
661410009281	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
661410009282	probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684
661410009283	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
661410009284	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
661410009285	Tetramer interface [polypeptide binding]; other site
661410009286	active site
661410009287	FMN-binding site [chemical binding]; other site
661410009288	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
661410009289	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
661410009290	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
661410009291	dimerization interface [polypeptide binding]; other site
661410009292	active site
661410009293	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
661410009294	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
661410009295	putative active site [active]
661410009296	Zn binding site [ion binding]; other site
661410009297	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
661410009298	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410009299	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
661410009300	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
661410009301	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
661410009302	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
661410009303	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
661410009304	carboxyltransferase (CT) interaction site; other site
661410009305	biotinylation site [posttranslational modification]; other site
661410009306	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
661410009307	putative active site pocket [active]
661410009308	dimerization interface [polypeptide binding]; other site
661410009309	putative catalytic residue [active]
661410009310	Acylphosphatase; Region: Acylphosphatase; pfam00708
661410009311	Protein of unknown function, DUF599; Region: DUF599; pfam04654
661410009312	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
661410009313	Uncharacterized conserved protein [Function unknown]; Region: COG1434
661410009314	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
661410009315	putative active site [active]
661410009316	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
661410009317	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
661410009318	putative C-terminal domain interface [polypeptide binding]; other site
661410009319	putative GSH binding site (G-site) [chemical binding]; other site
661410009320	putative dimer interface [polypeptide binding]; other site
661410009321	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
661410009322	putative N-terminal domain interface [polypeptide binding]; other site
661410009323	putative dimer interface [polypeptide binding]; other site
661410009324	putative substrate binding pocket (H-site) [chemical binding]; other site
661410009325	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
661410009326	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410009327	FeS/SAM binding site; other site
661410009328	Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269
661410009329	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
661410009330	motif 1; other site
661410009331	dimer interface [polypeptide binding]; other site
661410009332	active site
661410009333	motif 2; other site
661410009334	motif 3; other site
661410009335	elongation factor P; Validated; Region: PRK00529
661410009336	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
661410009337	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
661410009338	RNA binding site [nucleotide binding]; other site
661410009339	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
661410009340	RNA binding site [nucleotide binding]; other site
661410009341	Protein of unknown function (DUF1624); Region: DUF1624; pfam07786
661410009342	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
661410009343	DNA-binding site [nucleotide binding]; DNA binding site
661410009344	RNA-binding motif; other site
661410009345	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
661410009346	DNA-binding site [nucleotide binding]; DNA binding site
661410009347	RNA-binding motif; other site
661410009348	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
661410009349	magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406
661410009350	Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240
661410009351	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
661410009352	metal ion-dependent adhesion site (MIDAS); other site
661410009353	putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056
661410009354	phytoene desaturase; Region: crtI_fam; TIGR02734
661410009355	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
661410009356	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
661410009357	active site lid residues [active]
661410009358	substrate binding pocket [chemical binding]; other site
661410009359	catalytic residues [active]
661410009360	substrate-Mg2+ binding site; other site
661410009361	aspartate-rich region 1; other site
661410009362	aspartate-rich region 2; other site
661410009363	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
661410009364	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
661410009365	UreF; Region: UreF; pfam01730
661410009366	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
661410009367	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
661410009368	dimer interface [polypeptide binding]; other site
661410009369	catalytic residues [active]
661410009370	Domain of unknown function DUF29; Region: DUF29; pfam01724
661410009371	urease subunit alpha; Reviewed; Region: ureC; PRK13207
661410009372	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
661410009373	subunit interactions [polypeptide binding]; other site
661410009374	active site
661410009375	flap region; other site
661410009376	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
661410009377	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
661410009378	Zn2+ binding site [ion binding]; other site
661410009379	Mg2+ binding site [ion binding]; other site
661410009380	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
661410009381	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
661410009382	alpha-gamma subunit interface [polypeptide binding]; other site
661410009383	beta-gamma subunit interface [polypeptide binding]; other site
661410009384	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
661410009385	alpha-beta subunit interface [polypeptide binding]; other site
661410009386	UreD urease accessory protein; Region: UreD; pfam01774
661410009387	Flavin Reductases; Region: FlaRed; cl00801
661410009388	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222
661410009389	active site
661410009390	homotetramer interface [polypeptide binding]; other site
661410009391	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
661410009392	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
661410009393	active site
661410009394	putative substrate binding pocket [chemical binding]; other site
661410009395	GcrA cell cycle regulator; Region: GcrA; cl11564
661410009396	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
661410009397	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410009398	NAD(P) binding site [chemical binding]; other site
661410009399	active site
661410009400	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
661410009401	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
661410009402	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
661410009403	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
661410009404	similar to hypothetical protein; Evidence 6 : Doubtful CDS
661410009405	threonine dehydratase; Reviewed; Region: PRK09224
661410009406	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
661410009407	tetramer interface [polypeptide binding]; other site
661410009408	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410009409	catalytic residue [active]
661410009410	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
661410009411	putative Ile/Val binding site [chemical binding]; other site
661410009412	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
661410009413	putative Ile/Val binding site [chemical binding]; other site
661410009414	PilZ domain; Region: PilZ; pfam07238
661410009415	SlyX; Region: SlyX; pfam04102
661410009416	Porin subfamily; Region: Porin_2; pfam02530
661410009417	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
661410009418	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
661410009419	Class II flagellar assembly regulator; Region: FliX; pfam10768
661410009420	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
661410009421	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
661410009422	Rod binding protein; Region: Rod-binding; cl01626
661410009423	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
661410009424	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
661410009425	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
661410009426	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786
661410009427	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
661410009428	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
661410009429	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
661410009430	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
661410009431	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689
661410009432	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
661410009433	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
661410009434	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK12785
661410009435	flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795
661410009436	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
661410009437	Uncharacterized conserved protein [Function unknown]; Region: COG3334
661410009438	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
661410009439	catalytic residues [active]
661410009440	dimer interface [polypeptide binding]; other site
661410009441	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
661410009442	Transglycosylase SLT domain; Region: SLT_2; pfam13406
661410009443	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
661410009444	N-acetyl-D-glucosamine binding site [chemical binding]; other site
661410009445	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
661410009446	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
661410009447	Elongation factor G, domain IV; Region: EFG_IV; smart00889
661410009448	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
661410009449	Uncharacterized conserved protein [Function unknown]; Region: COG3791
661410009450	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
661410009451	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
661410009452	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
661410009453	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410009454	dimer interface [polypeptide binding]; other site
661410009455	phosphorylation site [posttranslational modification]
661410009456	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410009457	ATP binding site [chemical binding]; other site
661410009458	Mg2+ binding site [ion binding]; other site
661410009459	G-X-G motif; other site
661410009460	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
661410009461	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410009462	active site
661410009463	phosphorylation site [posttranslational modification]
661410009464	intermolecular recognition site; other site
661410009465	dimerization interface [polypeptide binding]; other site
661410009466	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410009467	ATP binding site [chemical binding]; other site
661410009468	Walker A motif; other site
661410009469	Walker B motif; other site
661410009470	arginine finger; other site
661410009471	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
661410009472	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410009473	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410009474	metal binding site [ion binding]; metal-binding site
661410009475	active site
661410009476	I-site; other site
661410009477	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410009478	GAF domain; Region: GAF; pfam01590
661410009479	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410009480	PAS fold; Region: PAS_3; pfam08447
661410009481	putative active site [active]
661410009482	heme pocket [chemical binding]; other site
661410009483	PAS fold; Region: PAS_7; pfam12860
661410009484	PAS domain S-box; Region: sensory_box; TIGR00229
661410009485	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410009486	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410009487	metal binding site [ion binding]; metal-binding site
661410009488	active site
661410009489	I-site; other site
661410009490	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410009491	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
661410009492	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
661410009493	GatB domain; Region: GatB_Yqey; smart00845
661410009494	Cation efflux family; Region: Cation_efflux; pfam01545
661410009495	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
661410009496	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
661410009497	hypothetical protein; Provisional; Region: PRK08244
661410009498	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
661410009499	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
661410009500	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
661410009501	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
661410009502	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
661410009503	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
661410009504	Leucine rich repeat; Region: LRR_8; pfam13855
661410009505	Leucine rich repeat; Region: LRR_8; pfam13855
661410009506	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
661410009507	active site
661410009508	ATP binding site [chemical binding]; other site
661410009509	substrate binding site [chemical binding]; other site
661410009510	activation loop (A-loop); other site
661410009511	Uncharacterized conserved protein [Function unknown]; Region: COG3025
661410009512	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
661410009513	putative active site [active]
661410009514	putative metal binding residues [ion binding]; other site
661410009515	signature motif; other site
661410009516	putative triphosphate binding site [ion binding]; other site
661410009517	CHAD domain; Region: CHAD; pfam05235
661410009518	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
661410009519	putative active site [active]
661410009520	putative metal binding residues [ion binding]; other site
661410009521	signature motif; other site
661410009522	putative dimer interface [polypeptide binding]; other site
661410009523	putative phosphate binding site [ion binding]; other site
661410009524	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
661410009525	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
661410009526	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
661410009527	DNA binding residues [nucleotide binding]
661410009528	SnoaL-like domain; Region: SnoaL_2; pfam12680
661410009529	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
661410009530	Uncharacterized conserved protein [Function unknown]; Region: COG2128
661410009531	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
661410009532	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
661410009533	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
661410009534	catalytic loop [active]
661410009535	iron binding site [ion binding]; other site
661410009536	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
661410009537	cyclase homology domain; Region: CHD; cd07302
661410009538	nucleotidyl binding site; other site
661410009539	metal binding site [ion binding]; metal-binding site
661410009540	dimer interface [polypeptide binding]; other site
661410009541	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
661410009542	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
661410009543	Major royal jelly protein; Region: MRJP; pfam03022
661410009544	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
661410009545	putative heme binding pocket [chemical binding]; other site
661410009546	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
661410009547	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
661410009548	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
661410009549	aminotransferase; Validated; Region: PRK09148
661410009550	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
661410009551	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410009552	homodimer interface [polypeptide binding]; other site
661410009553	catalytic residue [active]
661410009554	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
661410009555	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
661410009556	putative cation:proton antiport protein; Provisional; Region: PRK10669
661410009557	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
661410009558	TrkA-N domain; Region: TrkA_N; pfam02254
661410009559	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
661410009560	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
661410009561	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
661410009562	TrbC/VIRB2 family; Region: TrbC; pfam04956
661410009563	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
661410009564	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
661410009565	dimer interface [polypeptide binding]; other site
661410009566	motif 1; other site
661410009567	active site
661410009568	motif 2; other site
661410009569	motif 3; other site
661410009570	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
661410009571	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
661410009572	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
661410009573	SnoaL-like domain; Region: SnoaL_2; pfam12680
661410009574	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
661410009575	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
661410009576	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
661410009577	tandem repeat interface [polypeptide binding]; other site
661410009578	oligomer interface [polypeptide binding]; other site
661410009579	active site residues [active]
661410009580	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
661410009581	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410009582	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
661410009583	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
661410009584	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
661410009585	substrate binding pocket [chemical binding]; other site
661410009586	chain length determination region; other site
661410009587	substrate-Mg2+ binding site; other site
661410009588	catalytic residues [active]
661410009589	aspartate-rich region 1; other site
661410009590	active site lid residues [active]
661410009591	aspartate-rich region 2; other site
661410009592	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
661410009593	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
661410009594	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
661410009595	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
661410009596	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
661410009597	binding surface
661410009598	TPR motif; other site
661410009599	TPR repeat; Region: TPR_11; pfam13414
661410009600	TPR repeat; Region: TPR_11; pfam13414
661410009601	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
661410009602	binding surface
661410009603	TPR motif; other site
661410009604	TPR repeat; Region: TPR_11; pfam13414
661410009605	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
661410009606	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
661410009607	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
661410009608	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
661410009609	Walker A/P-loop; other site
661410009610	ATP binding site [chemical binding]; other site
661410009611	Q-loop/lid; other site
661410009612	ABC transporter signature motif; other site
661410009613	Walker B; other site
661410009614	D-loop; other site
661410009615	H-loop/switch region; other site
661410009616	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
661410009617	putative active site [active]
661410009618	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
661410009619	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410009620	ATP binding site [chemical binding]; other site
661410009621	Mg2+ binding site [ion binding]; other site
661410009622	G-X-G motif; other site
661410009623	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
661410009624	anchoring element; other site
661410009625	dimer interface [polypeptide binding]; other site
661410009626	ATP binding site [chemical binding]; other site
661410009627	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
661410009628	active site
661410009629	metal binding site [ion binding]; metal-binding site
661410009630	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
661410009631	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
661410009632	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
661410009633	tetramer interface [polypeptide binding]; other site
661410009634	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410009635	catalytic residue [active]
661410009636	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
661410009637	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
661410009638	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410009639	Walker A/P-loop; other site
661410009640	ATP binding site [chemical binding]; other site
661410009641	Q-loop/lid; other site
661410009642	ABC transporter signature motif; other site
661410009643	Walker B; other site
661410009644	D-loop; other site
661410009645	H-loop/switch region; other site
661410009646	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410009647	Major Facilitator Superfamily; Region: MFS_1; pfam07690
661410009648	putative substrate translocation pore; other site
661410009649	PRC-barrel domain; Region: PRC; pfam05239
661410009650	SWIB/MDM2 domain; Region: SWIB; pfam02201
661410009651	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
661410009652	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410009653	NAD(P) binding site [chemical binding]; other site
661410009654	active site
661410009655	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410009656	Major Facilitator Superfamily; Region: MFS_1; pfam07690
661410009657	putative substrate translocation pore; other site
661410009658	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
661410009659	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
661410009660	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
661410009661	catalytic site [active]
661410009662	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
661410009663	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
661410009664	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
661410009665	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
661410009666	C-terminal domain interface [polypeptide binding]; other site
661410009667	GSH binding site (G-site) [chemical binding]; other site
661410009668	dimer interface [polypeptide binding]; other site
661410009669	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
661410009670	N-terminal domain interface [polypeptide binding]; other site
661410009671	putative dimer interface [polypeptide binding]; other site
661410009672	active site
661410009673	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
661410009674	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
661410009675	nucleoside/Zn binding site; other site
661410009676	dimer interface [polypeptide binding]; other site
661410009677	catalytic motif [active]
661410009678	spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886
661410009679	Short C-terminal domain; Region: SHOCT; pfam09851
661410009680	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
661410009681	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
661410009682	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
661410009683	active site
661410009684	catalytic site [active]
661410009685	histidine kinase; Provisional; Region: PRK13557
661410009686	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410009687	putative active site [active]
661410009688	heme pocket [chemical binding]; other site
661410009689	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410009690	dimer interface [polypeptide binding]; other site
661410009691	phosphorylation site [posttranslational modification]
661410009692	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410009693	ATP binding site [chemical binding]; other site
661410009694	Mg2+ binding site [ion binding]; other site
661410009695	G-X-G motif; other site
661410009696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410009697	active site
661410009698	phosphorylation site [posttranslational modification]
661410009699	intermolecular recognition site; other site
661410009700	dimerization interface [polypeptide binding]; other site
661410009701	isocitrate dehydrogenase; Validated; Region: PRK08299
661410009702	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
661410009703	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
661410009704	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
661410009705	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
661410009706	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
661410009707	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
661410009708	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
661410009709	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
661410009710	putative NAD(P) binding site [chemical binding]; other site
661410009711	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
661410009712	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410009713	dimerization interface [polypeptide binding]; other site
661410009714	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
661410009715	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410009716	dimer interface [polypeptide binding]; other site
661410009717	putative CheW interface [polypeptide binding]; other site
661410009718	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410009719	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
661410009720	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
661410009721	homodimer interface [polypeptide binding]; other site
661410009722	substrate-cofactor binding pocket; other site
661410009723	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410009724	catalytic residue [active]
661410009725	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410009726	active site
661410009727	phosphorylation site [posttranslational modification]
661410009728	intermolecular recognition site; other site
661410009729	dimerization interface [polypeptide binding]; other site
661410009730	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
661410009731	Cysteine-rich domain; Region: CCG; pfam02754
661410009732	Cysteine-rich domain; Region: CCG; pfam02754
661410009733	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
661410009734	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
661410009735	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
661410009736	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
661410009737	ATP binding site [chemical binding]; other site
661410009738	putative Mg++ binding site [ion binding]; other site
661410009739	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
661410009740	nucleotide binding region [chemical binding]; other site
661410009741	ATP-binding site [chemical binding]; other site
661410009742	DEAD/H associated; Region: DEAD_assoc; pfam08494
661410009743	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
661410009744	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
661410009745	putative active site [active]
661410009746	putative metal binding site [ion binding]; other site
661410009747	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
661410009748	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
661410009749	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
661410009750	putative ion selectivity filter; other site
661410009751	putative pore gating glutamate residue; other site
661410009752	putative H+/Cl- coupling transport residue; other site
661410009753	short chain dehydrogenase; Provisional; Region: PRK06197
661410009754	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
661410009755	putative NAD(P) binding site [chemical binding]; other site
661410009756	active site
661410009757	thiamine monophosphate kinase; Provisional; Region: PRK05731
661410009758	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
661410009759	ATP binding site [chemical binding]; other site
661410009760	dimerization interface [polypeptide binding]; other site
661410009761	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
661410009762	putative RNA binding site [nucleotide binding]; other site
661410009763	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
661410009764	homopentamer interface [polypeptide binding]; other site
661410009765	active site
661410009766	hypothetical protein; Validated; Region: PRK08238
661410009767	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
661410009768	Predicted membrane protein [Function unknown]; Region: COG2246
661410009769	GtrA-like protein; Region: GtrA; pfam04138
661410009770	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
661410009771	Lumazine binding domain; Region: Lum_binding; pfam00677
661410009772	Lumazine binding domain; Region: Lum_binding; pfam00677
661410009773	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
661410009774	catalytic motif [active]
661410009775	Zn binding site [ion binding]; other site
661410009776	RibD C-terminal domain; Region: RibD_C; cl17279
661410009777	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
661410009778	Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047
661410009779	ATP cone domain; Region: ATP-cone; pfam03477
661410009780	Predicted transcriptional regulator [Transcription]; Region: COG1959
661410009781	Transcriptional regulator; Region: Rrf2; cl17282
661410009782	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
661410009783	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
661410009784	dimer interface [polypeptide binding]; other site
661410009785	active site
661410009786	glycine-pyridoxal phosphate binding site [chemical binding]; other site
661410009787	folate binding site [chemical binding]; other site
661410009788	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
661410009789	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
661410009790	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
661410009791	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
661410009792	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
661410009793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336
661410009794	Thioredoxin; Region: Thioredoxin_4; pfam13462
661410009795	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
661410009796	Protein of unknown function (DUF721); Region: DUF721; cl02324
661410009797	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
661410009798	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
661410009799	minor groove reading motif; other site
661410009800	helix-hairpin-helix signature motif; other site
661410009801	substrate binding pocket [chemical binding]; other site
661410009802	active site
661410009803	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
661410009804	DNA binding and oxoG recognition site [nucleotide binding]
661410009805	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
661410009806	DNA methylase; Region: N6_N4_Mtase; pfam01555
661410009807	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
661410009808	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
661410009809	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
661410009810	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
661410009811	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
661410009812	Porin subfamily; Region: Porin_2; pfam02530
661410009813	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
661410009814	ligand binding site [chemical binding]; other site
661410009815	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
661410009816	cyclase homology domain; Region: CHD; cd07302
661410009817	nucleotidyl binding site; other site
661410009818	metal binding site [ion binding]; metal-binding site
661410009819	dimer interface [polypeptide binding]; other site
661410009820	HD domain; Region: HD_3; pfam13023
661410009821	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
661410009822	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
661410009823	N-acetyl-D-glucosamine binding site [chemical binding]; other site
661410009824	catalytic residue [active]
661410009825	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
661410009826	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
661410009827	dimer interface [polypeptide binding]; other site
661410009828	active site
661410009829	catalytic residue [active]
661410009830	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
661410009831	SmpB-tmRNA interface; other site
661410009832	Uncharacterized conserved protein [Function unknown]; Region: COG1432
661410009833	LabA_like proteins; Region: LabA; cd10911
661410009834	putative metal binding site [ion binding]; other site
661410009835	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
661410009836	active site
661410009837	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
661410009838	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
661410009839	Zn2+ binding site [ion binding]; other site
661410009840	Mg2+ binding site [ion binding]; other site
661410009841	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
661410009842	synthetase active site [active]
661410009843	NTP binding site [chemical binding]; other site
661410009844	metal binding site [ion binding]; metal-binding site
661410009845	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
661410009846	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
661410009847	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
661410009848	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
661410009849	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
661410009850	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
661410009851	Glycoprotease family; Region: Peptidase_M22; pfam00814
661410009852	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
661410009853	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
661410009854	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
661410009855	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
661410009856	putative acyl-acceptor binding pocket; other site
661410009857	MEKHLA domain; Region: MEKHLA; pfam08670
661410009858	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410009859	putative active site [active]
661410009860	heme pocket [chemical binding]; other site
661410009861	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
661410009862	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
661410009863	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410009864	FeS/SAM binding site; other site
661410009865	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
661410009866	PhoH-like protein; Region: PhoH; pfam02562
661410009867	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
661410009868	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
661410009869	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
661410009870	Transporter associated domain; Region: CorC_HlyC; smart01091
661410009871	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
661410009872	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
661410009873	putative active site [active]
661410009874	catalytic triad [active]
661410009875	putative dimer interface [polypeptide binding]; other site
661410009876	BA14K-like protein; Region: BA14K; pfam07886
661410009877	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
661410009878	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
661410009879	tetramer interface [polypeptide binding]; other site
661410009880	heme binding pocket [chemical binding]; other site
661410009881	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
661410009882	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410009883	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
661410009884	dimerization interface [polypeptide binding]; other site
661410009885	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
661410009886	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
661410009887	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
661410009888	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
661410009889	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
661410009890	putative active site [active]
661410009891	putative metal binding site [ion binding]; other site
661410009892	glutamate racemase; Provisional; Region: PRK00865
661410009893	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
661410009894	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
661410009895	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
661410009896	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
661410009897	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
661410009898	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
661410009899	active site
661410009900	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
661410009901	Protein of unknown function (DUF779); Region: DUF779; pfam05610
661410009902	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
661410009903	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
661410009904	[4Fe-4S] binding site [ion binding]; other site
661410009905	molybdopterin cofactor binding site; other site
661410009906	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
661410009907	molybdopterin cofactor binding site; other site
661410009908	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
661410009909	siroheme synthase; Provisional; Region: cysG; PRK10637
661410009910	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
661410009911	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
661410009912	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
661410009913	active site
661410009914	SAM binding site [chemical binding]; other site
661410009915	homodimer interface [polypeptide binding]; other site
661410009916	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
661410009917	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
661410009918	Cu(I) binding site [ion binding]; other site
661410009919	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
661410009920	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
661410009921	DXD motif; other site
661410009922	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
661410009923	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
661410009924	substrate binding pocket [chemical binding]; other site
661410009925	membrane-bound complex binding site; other site
661410009926	hinge residues; other site
661410009927	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
661410009928	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
661410009929	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
661410009930	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
661410009931	metal ion-dependent adhesion site (MIDAS); other site
661410009932	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
661410009933	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
661410009934	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
661410009935	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
661410009936	HSP70 interaction site [polypeptide binding]; other site
661410009937	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
661410009938	hypothetical protein; Provisional; Region: PRK09256
661410009939	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
661410009940	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
661410009941	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410009942	S-adenosylmethionine binding site [chemical binding]; other site
661410009943	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
661410009944	DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120
661410009945	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
661410009946	active site
661410009947	DNA binding site [nucleotide binding]
661410009948	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
661410009949	DNA binding site [nucleotide binding]
661410009950	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
661410009951	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
661410009952	Protein of unknown function, DUF606; Region: DUF606; pfam04657
661410009953	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
661410009954	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
661410009955	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
661410009956	substrate binding site [chemical binding]; other site
661410009957	oxyanion hole (OAH) forming residues; other site
661410009958	trimer interface [polypeptide binding]; other site
661410009959	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
661410009960	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
661410009961	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410009962	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
661410009963	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
661410009964	dimer interface [polypeptide binding]; other site
661410009965	active site
661410009966	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
661410009967	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
661410009968	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
661410009969	FAD binding site [chemical binding]; other site
661410009970	substrate binding site [chemical binding]; other site
661410009971	catalytic residues [active]
661410009972	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
661410009973	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
661410009974	Sel1-like repeats; Region: SEL1; smart00671
661410009975	Sel1-like repeats; Region: SEL1; smart00671
661410009976	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
661410009977	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
661410009978	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
661410009979	active site
661410009980	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
661410009981	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
661410009982	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
661410009983	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
661410009984	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
661410009985	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
661410009986	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
661410009987	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
661410009988	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
661410009989	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410009990	catalytic residue [active]
661410009991	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
661410009992	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
661410009993	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
661410009994	Subunit III/VIIa interface [polypeptide binding]; other site
661410009995	Phospholipid binding site [chemical binding]; other site
661410009996	Subunit I/III interface [polypeptide binding]; other site
661410009997	Subunit III/VIb interface [polypeptide binding]; other site
661410009998	Subunit III/VIa interface; other site
661410009999	Subunit III/Vb interface [polypeptide binding]; other site
661410010000	Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; pfam04442
661410010001	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
661410010002	UbiA prenyltransferase family; Region: UbiA; pfam01040
661410010003	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
661410010004	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
661410010005	Subunit I/III interface [polypeptide binding]; other site
661410010006	D-pathway; other site
661410010007	Subunit I/VIIc interface [polypeptide binding]; other site
661410010008	Subunit I/IV interface [polypeptide binding]; other site
661410010009	Subunit I/II interface [polypeptide binding]; other site
661410010010	Low-spin heme (heme a) binding site [chemical binding]; other site
661410010011	Subunit I/VIIa interface [polypeptide binding]; other site
661410010012	Subunit I/VIa interface [polypeptide binding]; other site
661410010013	Dimer interface; other site
661410010014	Putative water exit pathway; other site
661410010015	Binuclear center (heme a3/CuB) [ion binding]; other site
661410010016	K-pathway; other site
661410010017	Subunit I/Vb interface [polypeptide binding]; other site
661410010018	Putative proton exit pathway; other site
661410010019	Subunit I/VIb interface; other site
661410010020	Subunit I/VIc interface [polypeptide binding]; other site
661410010021	Electron transfer pathway; other site
661410010022	Subunit I/VIIIb interface [polypeptide binding]; other site
661410010023	Subunit I/VIIb interface [polypeptide binding]; other site
661410010024	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
661410010025	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
661410010026	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
661410010027	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
661410010028	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
661410010029	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
661410010030	active site
661410010031	dimer interface [polypeptide binding]; other site
661410010032	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
661410010033	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
661410010034	active site
661410010035	FMN binding site [chemical binding]; other site
661410010036	substrate binding site [chemical binding]; other site
661410010037	3Fe-4S cluster binding site [ion binding]; other site
661410010038	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
661410010039	domain interface; other site
661410010040	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
661410010041	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
661410010042	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
661410010043	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
661410010044	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
661410010045	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
661410010046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410010047	active site
661410010048	phosphorylation site [posttranslational modification]
661410010049	intermolecular recognition site; other site
661410010050	dimerization interface [polypeptide binding]; other site
661410010051	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
661410010052	DNA binding residues [nucleotide binding]
661410010053	dimerization interface [polypeptide binding]; other site
661410010054	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
661410010055	active site
661410010056	catalytic triad [active]
661410010057	oxyanion hole [active]
661410010058	Transglycosylase SLT domain; Region: SLT_2; pfam13406
661410010059	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
661410010060	N-acetyl-D-glucosamine binding site [chemical binding]; other site
661410010061	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
661410010062	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
661410010063	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
661410010064	NAD binding site [chemical binding]; other site
661410010065	homodimer interface [polypeptide binding]; other site
661410010066	active site
661410010067	substrate binding site [chemical binding]; other site
661410010068	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
661410010069	active site
661410010070	tetramer interface; other site
661410010071	N-formylglutamate amidohydrolase; Region: FGase; cl01522
661410010072	Response regulator receiver domain; Region: Response_reg; pfam00072
661410010073	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410010074	active site
661410010075	phosphorylation site [posttranslational modification]
661410010076	intermolecular recognition site; other site
661410010077	dimerization interface [polypeptide binding]; other site
661410010078	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
661410010079	GSH binding site [chemical binding]; other site
661410010080	catalytic residues [active]
661410010081	Predicted amidohydrolase [General function prediction only]; Region: COG0388
661410010082	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
661410010083	putative active site [active]
661410010084	catalytic triad [active]
661410010085	dimer interface [polypeptide binding]; other site
661410010086	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
661410010087	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410010088	PAS domain; Region: PAS_9; pfam13426
661410010089	putative active site [active]
661410010090	heme pocket [chemical binding]; other site
661410010091	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410010092	Histidine kinase; Region: HisKA_2; pfam07568
661410010093	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410010094	ATP binding site [chemical binding]; other site
661410010095	Mg2+ binding site [ion binding]; other site
661410010096	G-X-G motif; other site
661410010097	methionine sulfoxide reductase A; Provisional; Region: PRK00058
661410010098	hypothetical protein; Provisional; Region: PRK05208
661410010099	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
661410010100	PRC-barrel domain; Region: PRC; pfam05239
661410010101	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
661410010102	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
661410010103	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
661410010104	catalytic residues [active]
661410010105	argininosuccinate lyase; Provisional; Region: PRK00855
661410010106	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
661410010107	active sites [active]
661410010108	tetramer interface [polypeptide binding]; other site
661410010109	glutamine-tRNA ligase; Region: PLN02859
661410010110	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
661410010111	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
661410010112	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
661410010113	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
661410010114	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
661410010115	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
661410010116	motif II; other site
661410010117	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
661410010118	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
661410010119	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
661410010120	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
661410010121	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
661410010122	IncA protein; Region: IncA; pfam04156
661410010123	PAS domain; Region: PAS_8; pfam13188
661410010124	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410010125	PAS fold; Region: PAS_3; pfam08447
661410010126	putative active site [active]
661410010127	heme pocket [chemical binding]; other site
661410010128	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410010129	PAS fold; Region: PAS_3; pfam08447
661410010130	putative active site [active]
661410010131	heme pocket [chemical binding]; other site
661410010132	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410010133	HWE histidine kinase; Region: HWE_HK; pfam07536
661410010134	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
661410010135	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
661410010136	Probable Catalytic site; other site
661410010137	metal-binding site
661410010138	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
661410010139	active site
661410010140	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
661410010141	Peptidase family M48; Region: Peptidase_M48; pfam01435
661410010142	PA26 p53-induced protein (sestrin); Region: PA26; pfam04636
661410010143	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
661410010144	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410010145	non-specific DNA binding site [nucleotide binding]; other site
661410010146	salt bridge; other site
661410010147	sequence-specific DNA binding site [nucleotide binding]; other site
661410010148	S-adenosylmethionine synthetase; Validated; Region: PRK05250
661410010149	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
661410010150	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
661410010151	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
661410010152	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
661410010153	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
661410010154	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
661410010155	active site
661410010156	interdomain interaction site; other site
661410010157	putative metal-binding site [ion binding]; other site
661410010158	nucleotide binding site [chemical binding]; other site
661410010159	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
661410010160	domain I; other site
661410010161	DNA binding groove [nucleotide binding]
661410010162	phosphate binding site [ion binding]; other site
661410010163	domain II; other site
661410010164	domain III; other site
661410010165	nucleotide binding site [chemical binding]; other site
661410010166	catalytic site [active]
661410010167	domain IV; other site
661410010168	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
661410010169	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
661410010170	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
661410010171	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
661410010172	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
661410010173	bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108
661410010174	Moco binding site; other site
661410010175	metal coordination site [ion binding]; other site
661410010176	Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292
661410010177	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
661410010178	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
661410010179	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
661410010180	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
661410010181	dihydroorotase; Validated; Region: PRK09059
661410010182	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
661410010183	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
661410010184	active site
661410010185	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
661410010186	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
661410010187	DNA protecting protein DprA; Region: dprA; TIGR00732
661410010188	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
661410010189	active site
661410010190	catalytic triad [active]
661410010191	oxyanion hole [active]
661410010192	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
661410010193	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
661410010194	conserved cys residue [active]
661410010195	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
661410010196	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
661410010197	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
661410010198	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
661410010199	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
661410010200	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
661410010201	Protein export membrane protein; Region: SecD_SecF; cl14618
661410010202	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410010203	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410010204	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410010205	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
661410010206	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410010207	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
661410010208	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
661410010209	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
661410010210	catalytic residue [active]
661410010211	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
661410010212	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
661410010213	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
661410010214	Usg-like family; Region: Usg; cl11567
661410010215	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
661410010216	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
661410010217	ring oligomerisation interface [polypeptide binding]; other site
661410010218	ATP/Mg binding site [chemical binding]; other site
661410010219	stacking interactions; other site
661410010220	hinge regions; other site
661410010221	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
661410010222	oligomerisation interface [polypeptide binding]; other site
661410010223	mobile loop; other site
661410010224	roof hairpin; other site
661410010225	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
661410010226	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
661410010227	active site
661410010228	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
661410010229	NMT1-like family; Region: NMT1_2; pfam13379
661410010230	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
661410010231	Moco binding site; other site
661410010232	metal coordination site [ion binding]; other site
661410010233	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
661410010234	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
661410010235	membrane-bound complex binding site; other site
661410010236	hinge residues; other site
661410010237	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
661410010238	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
661410010239	xanthine permease; Region: pbuX; TIGR03173
661410010240	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
661410010241	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
661410010242	putative catalytic residue [active]
661410010243	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
661410010244	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
661410010245	Walker A/P-loop; other site
661410010246	ATP binding site [chemical binding]; other site
661410010247	Q-loop/lid; other site
661410010248	ABC transporter signature motif; other site
661410010249	Walker B; other site
661410010250	D-loop; other site
661410010251	H-loop/switch region; other site
661410010252	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
661410010253	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410010254	dimer interface [polypeptide binding]; other site
661410010255	conserved gate region; other site
661410010256	putative PBP binding loops; other site
661410010257	ABC-ATPase subunit interface; other site
661410010258	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
661410010259	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
661410010260	substrate binding pocket [chemical binding]; other site
661410010261	membrane-bound complex binding site; other site
661410010262	NosL; Region: NosL; cl01769
661410010263	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410010264	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
661410010265	ligand binding site [chemical binding]; other site
661410010266	flexible hinge region; other site
661410010267	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
661410010268	putative switch regulator; other site
661410010269	non-specific DNA interactions [nucleotide binding]; other site
661410010270	DNA binding site [nucleotide binding]
661410010271	sequence specific DNA binding site [nucleotide binding]; other site
661410010272	putative cAMP binding site [chemical binding]; other site
661410010273	HEAT repeats; Region: HEAT_2; pfam13646
661410010274	HEAT repeats; Region: HEAT_2; pfam13646
661410010275	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
661410010276	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
661410010277	putative oxidoreductase; Provisional; Region: PRK08275
661410010278	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
661410010279	Protein of unknown function (DUF971); Region: DUF971; pfam06155
661410010280	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410010281	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410010282	metal binding site [ion binding]; metal-binding site
661410010283	active site
661410010284	I-site; other site
661410010285	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410010286	Methyltransferase domain; Region: Methyltransf_25; pfam13649
661410010287	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
661410010288	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
661410010289	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
661410010290	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
661410010291	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410010292	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
661410010293	putative active site [active]
661410010294	heme pocket [chemical binding]; other site
661410010295	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410010296	putative active site [active]
661410010297	heme pocket [chemical binding]; other site
661410010298	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410010299	dimer interface [polypeptide binding]; other site
661410010300	phosphorylation site [posttranslational modification]
661410010301	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410010302	ATP binding site [chemical binding]; other site
661410010303	Mg2+ binding site [ion binding]; other site
661410010304	G-X-G motif; other site
661410010305	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410010306	active site
661410010307	phosphorylation site [posttranslational modification]
661410010308	intermolecular recognition site; other site
661410010309	dimerization interface [polypeptide binding]; other site
661410010310	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
661410010311	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410010312	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
661410010313	putative dimerization interface [polypeptide binding]; other site
661410010314	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
661410010315	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
661410010316	TM-ABC transporter signature motif; other site
661410010317	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
661410010318	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
661410010319	TM-ABC transporter signature motif; other site
661410010320	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
661410010321	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
661410010322	Walker A/P-loop; other site
661410010323	ATP binding site [chemical binding]; other site
661410010324	Q-loop/lid; other site
661410010325	ABC transporter signature motif; other site
661410010326	Walker B; other site
661410010327	D-loop; other site
661410010328	H-loop/switch region; other site
661410010329	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
661410010330	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
661410010331	Walker A/P-loop; other site
661410010332	ATP binding site [chemical binding]; other site
661410010333	Q-loop/lid; other site
661410010334	ABC transporter signature motif; other site
661410010335	Walker B; other site
661410010336	D-loop; other site
661410010337	H-loop/switch region; other site
661410010338	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
661410010339	putative amidase; Provisional; Region: PRK06169
661410010340	Amidase; Region: Amidase; cl11426
661410010341	acylamide amidohydrolase; Provisional; Region: amiE; PRK13286
661410010342	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
661410010343	multimer interface [polypeptide binding]; other site
661410010344	active site
661410010345	catalytic triad [active]
661410010346	dimer interface [polypeptide binding]; other site
661410010347	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
661410010348	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
661410010349	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
661410010350	hypothetical protein; Validated; Region: PRK07581
661410010351	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
661410010352	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
661410010353	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
661410010354	Walker A/P-loop; other site
661410010355	ATP binding site [chemical binding]; other site
661410010356	Q-loop/lid; other site
661410010357	ABC transporter signature motif; other site
661410010358	Walker B; other site
661410010359	D-loop; other site
661410010360	H-loop/switch region; other site
661410010361	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
661410010362	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
661410010363	Walker A/P-loop; other site
661410010364	ATP binding site [chemical binding]; other site
661410010365	Q-loop/lid; other site
661410010366	ABC transporter signature motif; other site
661410010367	Walker B; other site
661410010368	D-loop; other site
661410010369	H-loop/switch region; other site
661410010370	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
661410010371	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
661410010372	TM-ABC transporter signature motif; other site
661410010373	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
661410010374	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
661410010375	TM-ABC transporter signature motif; other site
661410010376	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
661410010377	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
661410010378	putative ligand binding site [chemical binding]; other site
661410010379	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
661410010380	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410010381	dimer interface [polypeptide binding]; other site
661410010382	phosphorylation site [posttranslational modification]
661410010383	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
661410010384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410010385	ATP binding site [chemical binding]; other site
661410010386	Mg2+ binding site [ion binding]; other site
661410010387	G-X-G motif; other site
661410010388	Response regulator receiver domain; Region: Response_reg; pfam00072
661410010389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410010390	active site
661410010391	phosphorylation site [posttranslational modification]
661410010392	intermolecular recognition site; other site
661410010393	dimerization interface [polypeptide binding]; other site
661410010394	Response regulator receiver domain; Region: Response_reg; pfam00072
661410010395	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410010396	active site
661410010397	phosphorylation site [posttranslational modification]
661410010398	intermolecular recognition site; other site
661410010399	dimerization interface [polypeptide binding]; other site
661410010400	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
661410010401	DNA binding residues [nucleotide binding]
661410010402	dimerization interface [polypeptide binding]; other site
661410010403	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
661410010404	similar to hypothetical protein; Evidence 6 : Doubtful CDS
661410010405	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
661410010406	active site
661410010407	SAM binding site [chemical binding]; other site
661410010408	homodimer interface [polypeptide binding]; other site
661410010409	Predicted periplasmic protein [Function unknown]; Region: COG3904
661410010410	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
661410010411	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
661410010412	P-loop; other site
661410010413	Magnesium ion binding site [ion binding]; other site
661410010414	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
661410010415	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
661410010416	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
661410010417	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
661410010418	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
661410010419	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
661410010420	active site
661410010421	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
661410010422	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
661410010423	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
661410010424	active site
661410010425	HIGH motif; other site
661410010426	KMSK motif region; other site
661410010427	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
661410010428	tRNA binding surface [nucleotide binding]; other site
661410010429	anticodon binding site; other site
661410010430	Sporulation related domain; Region: SPOR; pfam05036
661410010431	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
661410010432	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
661410010433	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
661410010434	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
661410010435	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
661410010436	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
661410010437	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410010438	putative substrate translocation pore; other site
661410010439	FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566
661410010440	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
661410010441	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
661410010442	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
661410010443	substrate binding pocket [chemical binding]; other site
661410010444	membrane-bound complex binding site; other site
661410010445	hinge residues; other site
661410010446	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
661410010447	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410010448	dimer interface [polypeptide binding]; other site
661410010449	conserved gate region; other site
661410010450	putative PBP binding loops; other site
661410010451	ABC-ATPase subunit interface; other site
661410010452	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
661410010453	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
661410010454	Walker A/P-loop; other site
661410010455	ATP binding site [chemical binding]; other site
661410010456	Q-loop/lid; other site
661410010457	ABC transporter signature motif; other site
661410010458	Walker B; other site
661410010459	D-loop; other site
661410010460	H-loop/switch region; other site
661410010461	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
661410010462	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
661410010463	active site
661410010464	dimer interface [polypeptide binding]; other site
661410010465	non-prolyl cis peptide bond; other site
661410010466	insertion regions; other site
661410010467	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
661410010468	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
661410010469	substrate binding pocket [chemical binding]; other site
661410010470	membrane-bound complex binding site; other site
661410010471	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
661410010472	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
661410010473	substrate binding pocket [chemical binding]; other site
661410010474	membrane-bound complex binding site; other site
661410010475	hinge residues; other site
661410010476	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
661410010477	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
661410010478	cytidine deaminase; Provisional; Region: PRK09027
661410010479	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
661410010480	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
661410010481	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
661410010482	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
661410010483	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
661410010484	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
661410010485	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
661410010486	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
661410010487	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
661410010488	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
661410010489	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
661410010490	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
661410010491	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
661410010492	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
661410010493	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
661410010494	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
661410010495	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
661410010496	classical (c) SDRs; Region: SDR_c; cd05233
661410010497	NAD(P) binding site [chemical binding]; other site
661410010498	active site
661410010499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410010500	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
661410010501	putative substrate translocation pore; other site
661410010502	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
661410010503	Beta-lactamase; Region: Beta-lactamase; pfam00144
661410010504	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
661410010505	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
661410010506	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
661410010507	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
661410010508	NAD(P) binding site [chemical binding]; other site
661410010509	catalytic residues [active]
661410010510	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
661410010511	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410010512	dimerization interface [polypeptide binding]; other site
661410010513	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410010514	dimer interface [polypeptide binding]; other site
661410010515	putative CheW interface [polypeptide binding]; other site
661410010516	pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099
661410010517	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
661410010518	dimer interface [polypeptide binding]; other site
661410010519	active site
661410010520	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
661410010521	catalytic residues [active]
661410010522	substrate binding site [chemical binding]; other site
661410010523	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
661410010524	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
661410010525	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
661410010526	acyl-activating enzyme (AAE) consensus motif; other site
661410010527	acyl-activating enzyme (AAE) consensus motif; other site
661410010528	AMP binding site [chemical binding]; other site
661410010529	active site
661410010530	CoA binding site [chemical binding]; other site
661410010531	CoA binding site [chemical binding]; other site
661410010532	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
661410010533	Predicted membrane protein [Function unknown]; Region: COG2259
661410010534	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410010535	Major Facilitator Superfamily; Region: MFS_1; pfam07690
661410010536	putative substrate translocation pore; other site
661410010537	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
661410010538	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
661410010539	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
661410010540	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
661410010541	active site
661410010542	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
661410010543	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
661410010544	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410010545	S-adenosylmethionine binding site [chemical binding]; other site
661410010546	exopolyphosphatase; Region: exo_poly_only; TIGR03706
661410010547	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
661410010548	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
661410010549	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
661410010550	active site
661410010551	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
661410010552	putative acyl-acceptor binding pocket; other site
661410010553	phytoene desaturase; Region: crtI_fam; TIGR02734
661410010554	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
661410010555	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
661410010556	catalytic triad [active]
661410010557	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
661410010558	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
661410010559	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
661410010560	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
661410010561	Walker A/P-loop; other site
661410010562	ATP binding site [chemical binding]; other site
661410010563	Q-loop/lid; other site
661410010564	ABC transporter signature motif; other site
661410010565	Walker B; other site
661410010566	D-loop; other site
661410010567	H-loop/switch region; other site
661410010568	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
661410010569	phytoene desaturase; Region: crtI_fam; TIGR02734
661410010570	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
661410010571	HerA helicase [Replication, recombination, and repair]; Region: COG0433
661410010572	Domain of unknown function DUF87; Region: DUF87; pfam01935
661410010573	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
661410010574	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
661410010575	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
661410010576	dimer interaction site [polypeptide binding]; other site
661410010577	substrate-binding tunnel; other site
661410010578	active site
661410010579	catalytic site [active]
661410010580	substrate binding site [chemical binding]; other site
661410010581	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
661410010582	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
661410010583	putative active site [active]
661410010584	putative metal binding site [ion binding]; other site
661410010585	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
661410010586	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
661410010587	putative C-terminal domain interface [polypeptide binding]; other site
661410010588	putative GSH binding site (G-site) [chemical binding]; other site
661410010589	putative dimer interface [polypeptide binding]; other site
661410010590	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
661410010591	dimer interface [polypeptide binding]; other site
661410010592	N-terminal domain interface [polypeptide binding]; other site
661410010593	putative substrate binding pocket (H-site) [chemical binding]; other site
661410010594	Amidinotransferase; Region: Amidinotransf; cl12043
661410010595	putative membrane protein; Region: HpnL; TIGR03476
661410010596	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
661410010597	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
661410010598	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
661410010599	ligand binding site; other site
661410010600	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
661410010601	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
661410010602	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410010603	FeS/SAM binding site; other site
661410010604	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
661410010605	putative active site [active]
661410010606	YdjC motif; other site
661410010607	Mg binding site [ion binding]; other site
661410010608	putative homodimer interface [polypeptide binding]; other site
661410010609	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
661410010610	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
661410010611	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410010612	FeS/SAM binding site; other site
661410010613	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
661410010614	hopanoid-associated phosphorylase; Region: HpnG; TIGR03468
661410010615	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
661410010616	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
661410010617	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
661410010618	AAA domain; Region: AAA_33; pfam13671
661410010619	ATP-binding site [chemical binding]; other site
661410010620	Gluconate-6-phosphate binding site [chemical binding]; other site
661410010621	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
661410010622	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
661410010623	active site
661410010624	motif I; other site
661410010625	motif II; other site
661410010626	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
661410010627	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
661410010628	N-acetyl-D-glucosamine binding site [chemical binding]; other site
661410010629	catalytic residue [active]
661410010630	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
661410010631	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
661410010632	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
661410010633	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
661410010634	putative acyltransferase; Provisional; Region: PRK05790
661410010635	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
661410010636	dimer interface [polypeptide binding]; other site
661410010637	active site
661410010638	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
661410010639	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
661410010640	NAD(P) binding site [chemical binding]; other site
661410010641	homotetramer interface [polypeptide binding]; other site
661410010642	homodimer interface [polypeptide binding]; other site
661410010643	active site
661410010644	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
661410010645	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
661410010646	putative acyl-acceptor binding pocket; other site
661410010647	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
661410010648	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
661410010649	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
661410010650	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
661410010651	FAD binding domain; Region: FAD_binding_4; pfam01565
661410010652	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
661410010653	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
661410010654	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
661410010655	nudix motif; other site
661410010656	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
661410010657	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
661410010658	inhibitor-cofactor binding pocket; inhibition site
661410010659	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410010660	catalytic residue [active]
661410010661	Recombinase; Region: Recombinase; pfam07508
661410010662	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
661410010663	PBP superfamily domain; Region: PBP_like; pfam12727
661410010664	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410010665	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410010666	ligand binding site [chemical binding]; other site
661410010667	flexible hinge region; other site
661410010668	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
661410010669	putative switch regulator; other site
661410010670	non-specific DNA interactions [nucleotide binding]; other site
661410010671	DNA binding site [nucleotide binding]
661410010672	sequence specific DNA binding site [nucleotide binding]; other site
661410010673	putative cAMP binding site [chemical binding]; other site
661410010674	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
661410010675	OsmC-like protein; Region: OsmC; pfam02566
661410010676	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
661410010677	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
661410010678	NMT1-like family; Region: NMT1_2; pfam13379
661410010679	NMT1/THI5 like; Region: NMT1; pfam09084
661410010680	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
661410010681	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410010682	Walker A/P-loop; other site
661410010683	ATP binding site [chemical binding]; other site
661410010684	Q-loop/lid; other site
661410010685	ABC transporter signature motif; other site
661410010686	Walker B; other site
661410010687	D-loop; other site
661410010688	H-loop/switch region; other site
661410010689	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
661410010690	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
661410010691	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
661410010692	active site
661410010693	non-prolyl cis peptide bond; other site
661410010694	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
661410010695	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
661410010696	Walker A/P-loop; other site
661410010697	ATP binding site [chemical binding]; other site
661410010698	Q-loop/lid; other site
661410010699	ABC transporter signature motif; other site
661410010700	Walker B; other site
661410010701	D-loop; other site
661410010702	H-loop/switch region; other site
661410010703	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
661410010704	TM-ABC transporter signature motif; other site
661410010705	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
661410010706	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
661410010707	TM-ABC transporter signature motif; other site
661410010708	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
661410010709	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
661410010710	putative ligand binding site [chemical binding]; other site
661410010711	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
661410010712	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
661410010713	Walker A/P-loop; other site
661410010714	ATP binding site [chemical binding]; other site
661410010715	Q-loop/lid; other site
661410010716	ABC transporter signature motif; other site
661410010717	Walker B; other site
661410010718	D-loop; other site
661410010719	H-loop/switch region; other site
661410010720	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
661410010721	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
661410010722	active site
661410010723	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
661410010724	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
661410010725	putative dimer interface [polypeptide binding]; other site
661410010726	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410010727	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410010728	ligand binding site [chemical binding]; other site
661410010729	flexible hinge region; other site
661410010730	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
661410010731	Universal stress protein family; Region: Usp; pfam00582
661410010732	Ligand Binding Site [chemical binding]; other site
661410010733	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410010734	Ligand Binding Site [chemical binding]; other site
661410010735	Protein required for attachment to host cells; Region: Host_attach; pfam10116
661410010736	BON domain; Region: BON; cl02771
661410010737	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410010738	Ligand Binding Site [chemical binding]; other site
661410010739	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410010740	ligand binding site [chemical binding]; other site
661410010741	flexible hinge region; other site
661410010742	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
661410010743	putative switch regulator; other site
661410010744	non-specific DNA interactions [nucleotide binding]; other site
661410010745	DNA binding site [nucleotide binding]
661410010746	sequence specific DNA binding site [nucleotide binding]; other site
661410010747	putative cAMP binding site [chemical binding]; other site
661410010748	response regulator FixJ; Provisional; Region: fixJ; PRK09390
661410010749	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410010750	active site
661410010751	phosphorylation site [posttranslational modification]
661410010752	intermolecular recognition site; other site
661410010753	dimerization interface [polypeptide binding]; other site
661410010754	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
661410010755	DNA binding residues [nucleotide binding]
661410010756	dimerization interface [polypeptide binding]; other site
661410010757	PAS domain; Region: PAS_9; pfam13426
661410010758	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410010759	putative active site [active]
661410010760	heme pocket [chemical binding]; other site
661410010761	PAS domain S-box; Region: sensory_box; TIGR00229
661410010762	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410010763	putative active site [active]
661410010764	heme pocket [chemical binding]; other site
661410010765	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410010766	dimer interface [polypeptide binding]; other site
661410010767	phosphorylation site [posttranslational modification]
661410010768	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410010769	ATP binding site [chemical binding]; other site
661410010770	Mg2+ binding site [ion binding]; other site
661410010771	G-X-G motif; other site
661410010772	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410010773	Ligand Binding Site [chemical binding]; other site
661410010774	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410010775	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410010776	active site
661410010777	phosphorylation site [posttranslational modification]
661410010778	intermolecular recognition site; other site
661410010779	dimerization interface [polypeptide binding]; other site
661410010780	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
661410010781	Zn2+ binding site [ion binding]; other site
661410010782	Mg2+ binding site [ion binding]; other site
661410010783	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
661410010784	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410010785	dimer interface [polypeptide binding]; other site
661410010786	phosphorylation site [posttranslational modification]
661410010787	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410010788	ATP binding site [chemical binding]; other site
661410010789	Mg2+ binding site [ion binding]; other site
661410010790	G-X-G motif; other site
661410010791	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410010792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410010793	active site
661410010794	phosphorylation site [posttranslational modification]
661410010795	intermolecular recognition site; other site
661410010796	dimerization interface [polypeptide binding]; other site
661410010797	Hpt domain; Region: Hpt; pfam01627
661410010798	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
661410010799	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
661410010800	TadE-like protein; Region: TadE; pfam07811
661410010801	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
661410010802	TadE-like protein; Region: TadE; pfam07811
661410010803	Staphylococcal nuclease homologues; Region: SNc; smart00318
661410010804	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
661410010805	Catalytic site; other site
661410010806	Hint domain; Region: Hint_2; pfam13403
661410010807	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
661410010808	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
661410010809	active site
661410010810	DNA binding site [nucleotide binding]
661410010811	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
661410010812	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
661410010813	Catalytic site [active]
661410010814	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
661410010815	sequence-specific DNA binding site [nucleotide binding]; other site
661410010816	salt bridge; other site
661410010817	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
661410010818	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
661410010819	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410010820	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410010821	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
661410010822	putative effector binding pocket; other site
661410010823	dimerization interface [polypeptide binding]; other site
661410010824	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410010825	PAS domain; Region: PAS_9; pfam13426
661410010826	putative active site [active]
661410010827	heme pocket [chemical binding]; other site
661410010828	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
661410010829	TIGR02594 family protein; Region: TIGR02594
661410010830	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
661410010831	active site
661410010832	DNA binding site [nucleotide binding]
661410010833	Int/Topo IB signature motif; other site
661410010834	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
661410010835	non-specific DNA binding site [nucleotide binding]; other site
661410010836	salt bridge; other site
661410010837	sequence-specific DNA binding site [nucleotide binding]; other site
661410010838	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
661410010839	Divergent AAA domain; Region: AAA_4; pfam04326
661410010840	Methyltransferase domain; Region: Methyltransf_26; pfam13659
661410010841	Winged helix-turn helix; Region: HTH_29; pfam13551
661410010842	Integrase core domain; Region: rve; pfam00665
661410010843	Integrase core domain; Region: rve_3; pfam13683
661410010844	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
661410010845	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
661410010846	Integrase core domain; Region: rve_3; pfam13683
661410010847	putative transposase OrfB; Reviewed; Region: PHA02517
661410010848	HTH-like domain; Region: HTH_21; pfam13276
661410010849	Integrase core domain; Region: rve; pfam00665
661410010850	Integrase core domain; Region: rve_3; pfam13683
661410010851	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
661410010852	Winged helix-turn helix; Region: HTH_29; pfam13551
661410010853	DNA-binding interface [nucleotide binding]; DNA binding site
661410010854	Phasin protein; Region: Phasin_2; pfam09361
661410010855	Transposase; Region: DEDD_Tnp_IS110; pfam01548
661410010856	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
661410010857	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
661410010858	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
661410010859	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
661410010860	putative NAD(P) binding site [chemical binding]; other site
661410010861	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
661410010862	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
661410010863	Predicted transcriptional regulators [Transcription]; Region: COG1733
661410010864	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
661410010865	Predicted amidohydrolase [General function prediction only]; Region: COG0388
661410010866	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580
661410010867	putative active site [active]
661410010868	catalytic triad [active]
661410010869	putative dimer interface [polypeptide binding]; other site
661410010870	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
661410010871	Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358
661410010872	putative ligand binding site [chemical binding]; other site
661410010873	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
661410010874	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
661410010875	TM-ABC transporter signature motif; other site
661410010876	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
661410010877	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
661410010878	TM-ABC transporter signature motif; other site
661410010879	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
661410010880	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
661410010881	Walker A/P-loop; other site
661410010882	ATP binding site [chemical binding]; other site
661410010883	Q-loop/lid; other site
661410010884	ABC transporter signature motif; other site
661410010885	Walker B; other site
661410010886	D-loop; other site
661410010887	H-loop/switch region; other site
661410010888	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
661410010889	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
661410010890	Walker A/P-loop; other site
661410010891	ATP binding site [chemical binding]; other site
661410010892	Q-loop/lid; other site
661410010893	ABC transporter signature motif; other site
661410010894	Walker B; other site
661410010895	D-loop; other site
661410010896	H-loop/switch region; other site
661410010897	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
661410010898	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
661410010899	alpha-gamma subunit interface [polypeptide binding]; other site
661410010900	beta-gamma subunit interface [polypeptide binding]; other site
661410010901	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
661410010902	alpha-beta subunit interface [polypeptide binding]; other site
661410010903	urease subunit alpha; Reviewed; Region: ureC; PRK13308
661410010904	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
661410010905	active site
661410010906	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
661410010907	UreD urease accessory protein; Region: UreD; pfam01774
661410010908	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
661410010909	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727
661410010910	dimer interface [polypeptide binding]; other site
661410010911	catalytic residues [active]
661410010912	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
661410010913	UreF; Region: UreF; pfam01730
661410010914	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
661410010915	ANTAR domain; Region: ANTAR; pfam03861
661410010916	Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357
661410010917	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
661410010918	ligand binding site [chemical binding]; other site
661410010919	regulator interaction site; other site
661410010920	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
661410010921	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
661410010922	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
661410010923	Integrase core domain; Region: rve; pfam00665
661410010924	transposase; Provisional; Region: PRK06526
661410010925	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410010926	Walker A motif; other site
661410010927	ATP binding site [chemical binding]; other site
661410010928	Walker B motif; other site
661410010929	arginine finger; other site
661410010930	Helix-turn-helix domain; Region: HTH_17; pfam12728
661410010931	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
661410010932	Y-family of DNA polymerases; Region: PolY; cl12025
661410010933	DNA binding site [nucleotide binding]
661410010934	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
661410010935	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
661410010936	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
661410010937	cyclase homology domain; Region: CHD; cd07302
661410010938	nucleotidyl binding site; other site
661410010939	metal binding site [ion binding]; metal-binding site
661410010940	dimer interface [polypeptide binding]; other site
661410010941	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
661410010942	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
661410010943	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410010944	Walker A/P-loop; other site
661410010945	ATP binding site [chemical binding]; other site
661410010946	Q-loop/lid; other site
661410010947	ABC transporter signature motif; other site
661410010948	Walker B; other site
661410010949	D-loop; other site
661410010950	H-loop/switch region; other site
661410010951	ABC transporter; Region: ABC_tran_2; pfam12848
661410010952	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
661410010953	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410010954	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410010955	dimerization interface [polypeptide binding]; other site
661410010956	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
661410010957	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410010958	ATP binding site [chemical binding]; other site
661410010959	Mg2+ binding site [ion binding]; other site
661410010960	G-X-G motif; other site
661410010961	osmolarity response regulator; Provisional; Region: ompR; PRK09468
661410010962	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410010963	active site
661410010964	phosphorylation site [posttranslational modification]
661410010965	intermolecular recognition site; other site
661410010966	dimerization interface [polypeptide binding]; other site
661410010967	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410010968	DNA binding site [nucleotide binding]
661410010969	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
661410010970	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
661410010971	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410010972	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410010973	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
661410010974	putative effector binding pocket; other site
661410010975	dimerization interface [polypeptide binding]; other site
661410010976	short chain dehydrogenase; Provisional; Region: PRK06500
661410010977	classical (c) SDRs; Region: SDR_c; cd05233
661410010978	NAD(P) binding site [chemical binding]; other site
661410010979	active site
661410010980	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
661410010981	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
661410010982	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
661410010983	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410010984	NADH(P)-binding; Region: NAD_binding_10; pfam13460
661410010985	NAD(P) binding site [chemical binding]; other site
661410010986	active site
661410010987	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
661410010988	cyclase homology domain; Region: CHD; cd07302
661410010989	nucleotidyl binding site; other site
661410010990	metal binding site [ion binding]; metal-binding site
661410010991	dimer interface [polypeptide binding]; other site
661410010992	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
661410010993	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410010994	NADH(P)-binding; Region: NAD_binding_10; pfam13460
661410010995	NAD(P) binding site [chemical binding]; other site
661410010996	active site
661410010997	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
661410010998	MarR family; Region: MarR; pfam01047
661410010999	Fusaric acid resistance protein family; Region: FUSC; pfam04632
661410011000	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
661410011001	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
661410011002	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
661410011003	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410011004	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410011005	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
661410011006	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
661410011007	putative metal binding site [ion binding]; other site
661410011008	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
661410011009	active site
661410011010	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
661410011011	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
661410011012	metal binding site [ion binding]; metal-binding site
661410011013	putative dimer interface [polypeptide binding]; other site
661410011014	Predicted membrane protein [Function unknown]; Region: COG2860
661410011015	UPF0126 domain; Region: UPF0126; pfam03458
661410011016	UPF0126 domain; Region: UPF0126; pfam03458
661410011017	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
661410011018	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410011019	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
661410011020	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
661410011021	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410011022	Ligand Binding Site [chemical binding]; other site
661410011023	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410011024	Ligand Binding Site [chemical binding]; other site
661410011025	PAS domain; Region: PAS; smart00091
661410011026	PAS fold; Region: PAS_4; pfam08448
661410011027	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410011028	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410011029	metal binding site [ion binding]; metal-binding site
661410011030	active site
661410011031	I-site; other site
661410011032	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410011033	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
661410011034	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
661410011035	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
661410011036	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
661410011037	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
661410011038	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
661410011039	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
661410011040	catalytic residue [active]
661410011041	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
661410011042	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
661410011043	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
661410011044	NAD(P) binding site [chemical binding]; other site
661410011045	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
661410011046	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
661410011047	active site
661410011048	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
661410011049	homotrimer interaction site [polypeptide binding]; other site
661410011050	zinc binding site [ion binding]; other site
661410011051	CDP-binding sites; other site
661410011052	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
661410011053	HPP family; Region: HPP; pfam04982
661410011054	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
661410011055	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
661410011056	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
661410011057	catalytic residue [active]
661410011058	Predicted transcriptional regulator [Transcription]; Region: COG1959
661410011059	Transcriptional regulator; Region: Rrf2; cl17282
661410011060	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
661410011061	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
661410011062	heme-binding site [chemical binding]; other site
661410011063	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
661410011064	FAD binding pocket [chemical binding]; other site
661410011065	FAD binding motif [chemical binding]; other site
661410011066	phosphate binding motif [ion binding]; other site
661410011067	beta-alpha-beta structure motif; other site
661410011068	NAD binding pocket [chemical binding]; other site
661410011069	Heme binding  pocket [chemical binding]; other site
661410011070	PAS domain; Region: PAS_9; pfam13426
661410011071	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410011072	putative active site [active]
661410011073	heme pocket [chemical binding]; other site
661410011074	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
661410011075	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
661410011076	Transcriptional regulators [Transcription]; Region: GntR; COG1802
661410011077	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
661410011078	DNA-binding site [nucleotide binding]; DNA binding site
661410011079	FCD domain; Region: FCD; pfam07729
661410011080	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
661410011081	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
661410011082	Transposase; Region: DDE_Tnp_ISL3; pfam01610
661410011083	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
661410011084	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
661410011085	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
661410011086	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410011087	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410011088	metal binding site [ion binding]; metal-binding site
661410011089	active site
661410011090	I-site; other site
661410011091	Cytochrome c; Region: Cytochrom_C; cl11414
661410011092	Cytochrome c; Region: Cytochrom_C; cl11414
661410011093	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
661410011094	D-pathway; other site
661410011095	Low-spin heme binding site [chemical binding]; other site
661410011096	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
661410011097	Putative water exit pathway; other site
661410011098	Binuclear center (active site) [active]
661410011099	K-pathway; other site
661410011100	Putative proton exit pathway; other site
661410011101	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
661410011102	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
661410011103	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
661410011104	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
661410011105	Cytochrome c; Region: Cytochrom_C; pfam00034
661410011106	Cytochrome c; Region: Cytochrom_C; cl11414
661410011107	Cytochrome c; Region: Cytochrom_C; cl11414
661410011108	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410011109	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
661410011110	ligand binding site [chemical binding]; other site
661410011111	flexible hinge region; other site
661410011112	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
661410011113	putative switch regulator; other site
661410011114	non-specific DNA interactions [nucleotide binding]; other site
661410011115	DNA binding site [nucleotide binding]
661410011116	sequence specific DNA binding site [nucleotide binding]; other site
661410011117	putative cAMP binding site [chemical binding]; other site
661410011118	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
661410011119	DNA-binding interface [nucleotide binding]; DNA binding site
661410011120	putative transposase OrfB; Reviewed; Region: PHA02517
661410011121	HTH-like domain; Region: HTH_21; pfam13276
661410011122	Integrase core domain; Region: rve; pfam00665
661410011123	Integrase core domain; Region: rve_3; pfam13683
661410011124	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
661410011125	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
661410011126	Sulfate transporter family; Region: Sulfate_transp; pfam00916
661410011127	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
661410011128	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
661410011129	putative active site [active]
661410011130	Zn binding site [ion binding]; other site
661410011131	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410011132	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
661410011133	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
661410011134	putative dimer interface [polypeptide binding]; other site
661410011135	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410011136	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410011137	ligand binding site [chemical binding]; other site
661410011138	flexible hinge region; other site
661410011139	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
661410011140	putative switch regulator; other site
661410011141	non-specific DNA interactions [nucleotide binding]; other site
661410011142	DNA binding site [nucleotide binding]
661410011143	sequence specific DNA binding site [nucleotide binding]; other site
661410011144	putative cAMP binding site [chemical binding]; other site
661410011145	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410011146	Ligand Binding Site [chemical binding]; other site
661410011147	Cytochrome c; Region: Cytochrom_C; cl11414
661410011148	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
661410011149	E3 interaction surface; other site
661410011150	lipoyl attachment site [posttranslational modification]; other site
661410011151	Ion channel; Region: Ion_trans_2; pfam07885
661410011152	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
661410011153	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
661410011154	response regulator; Provisional; Region: PRK13435
661410011155	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
661410011156	BON domain; Region: BON; pfam04972
661410011157	BON domain; Region: BON; pfam04972
661410011158	BON domain; Region: BON; pfam04972
661410011159	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
661410011160	Ligand Binding Site [chemical binding]; other site
661410011161	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410011162	Ligand Binding Site [chemical binding]; other site
661410011163	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410011164	Ligand Binding Site [chemical binding]; other site
661410011165	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
661410011166	Cytochrome c; Region: Cytochrom_C; pfam00034
661410011167	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410011168	Ligand Binding Site [chemical binding]; other site
661410011169	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410011170	Ligand Binding Site [chemical binding]; other site
661410011171	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
661410011172	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
661410011173	putative NAD(P) binding site [chemical binding]; other site
661410011174	putative substrate binding site [chemical binding]; other site
661410011175	catalytic Zn binding site [ion binding]; other site
661410011176	structural Zn binding site [ion binding]; other site
661410011177	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
661410011178	BON domain; Region: BON; pfam04972
661410011179	BON domain; Region: BON; pfam04972
661410011180	BON domain; Region: BON; pfam04972
661410011181	putative phosphoketolase; Provisional; Region: PRK05261
661410011182	XFP N-terminal domain; Region: XFP_N; pfam09364
661410011183	XFP C-terminal domain; Region: XFP_C; pfam09363
661410011184	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
661410011185	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
661410011186	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
661410011187	amphipathic channel; other site
661410011188	Asn-Pro-Ala signature motifs; other site
661410011189	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
661410011190	BON domain; Region: BON; pfam04972
661410011191	BON domain; Region: BON; pfam04972
661410011192	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
661410011193	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
661410011194	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
661410011195	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
661410011196	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
661410011197	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
661410011198	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
661410011199	motif II; other site
661410011200	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
661410011201	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410011202	Ligand Binding Site [chemical binding]; other site
661410011203	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410011204	ligand binding site [chemical binding]; other site
661410011205	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
661410011206	putative switch regulator; other site
661410011207	non-specific DNA interactions [nucleotide binding]; other site
661410011208	DNA binding site [nucleotide binding]
661410011209	sequence specific DNA binding site [nucleotide binding]; other site
661410011210	putative cAMP binding site [chemical binding]; other site
661410011211	Phasin protein; Region: Phasin_2; cl11491
661410011212	Response regulator receiver domain; Region: Response_reg; pfam00072
661410011213	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410011214	active site
661410011215	phosphorylation site [posttranslational modification]
661410011216	intermolecular recognition site; other site
661410011217	dimerization interface [polypeptide binding]; other site
661410011218	response regulator FixJ; Provisional; Region: fixJ; PRK09390
661410011219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410011220	active site
661410011221	phosphorylation site [posttranslational modification]
661410011222	intermolecular recognition site; other site
661410011223	dimerization interface [polypeptide binding]; other site
661410011224	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
661410011225	DNA binding residues [nucleotide binding]
661410011226	dimerization interface [polypeptide binding]; other site
661410011227	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410011228	PAS fold; Region: PAS_3; pfam08447
661410011229	putative active site [active]
661410011230	heme pocket [chemical binding]; other site
661410011231	PAS domain S-box; Region: sensory_box; TIGR00229
661410011232	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410011233	putative active site [active]
661410011234	heme pocket [chemical binding]; other site
661410011235	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410011236	dimer interface [polypeptide binding]; other site
661410011237	phosphorylation site [posttranslational modification]
661410011238	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410011239	ATP binding site [chemical binding]; other site
661410011240	Mg2+ binding site [ion binding]; other site
661410011241	G-X-G motif; other site
661410011242	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410011243	Ligand Binding Site [chemical binding]; other site
661410011244	Cytochrome c; Region: Cytochrom_C; pfam00034
661410011245	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410011246	Ligand Binding Site [chemical binding]; other site
661410011247	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
661410011248	Ligand Binding Site [chemical binding]; other site
661410011249	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
661410011250	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
661410011251	Transposase; Region: DEDD_Tnp_IS110; pfam01548
661410011252	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
661410011253	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
661410011254	Protein of unknown function (DUF2976); Region: DUF2976; cl12739
661410011255	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
661410011256	putative catalytic site [active]
661410011257	putative metal binding site [ion binding]; other site
661410011258	putative phosphate binding site [ion binding]; other site
661410011259	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
661410011260	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
661410011261	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410011262	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
661410011263	manganese transport regulator MntR; Provisional; Region: PRK11050
661410011264	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
661410011265	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
661410011266	manganese transport protein MntH; Reviewed; Region: PRK00701
661410011267	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
661410011268	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410011269	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410011270	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
661410011271	putative dimerization interface [polypeptide binding]; other site
661410011272	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
661410011273	transmembrane helices; other site
661410011274	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
661410011275	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
661410011276	Iron-sulfur protein interface; other site
661410011277	proximal quinone binding site [chemical binding]; other site
661410011278	SdhD (CybS) interface [polypeptide binding]; other site
661410011279	proximal heme binding site [chemical binding]; other site
661410011280	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
661410011281	putative SdhC subunit interface [polypeptide binding]; other site
661410011282	putative proximal heme binding site [chemical binding]; other site
661410011283	putative Iron-sulfur protein interface [polypeptide binding]; other site
661410011284	putative proximal quinone binding site; other site
661410011285	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
661410011286	L-aspartate oxidase; Provisional; Region: PRK06175
661410011287	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
661410011288	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
661410011289	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
661410011290	Protease inhibitor Inh; Region: Inh; pfam02974
661410011291	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
661410011292	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
661410011293	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
661410011294	putative active site [active]
661410011295	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
661410011296	Protein of unknown function, DUF606; Region: DUF606; pfam04657
661410011297	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
661410011298	substrate binding site [chemical binding]; other site
661410011299	oxyanion hole (OAH) forming residues; other site
661410011300	trimer interface [polypeptide binding]; other site
661410011301	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410011302	NAD(P) binding site [chemical binding]; other site
661410011303	active site
661410011304	short chain dehydrogenase; Provisional; Region: PRK08278
661410011305	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
661410011306	NAD(P) binding site [chemical binding]; other site
661410011307	homodimer interface [polypeptide binding]; other site
661410011308	active site
661410011309	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
661410011310	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
661410011311	Cl binding site [ion binding]; other site
661410011312	oligomer interface [polypeptide binding]; other site
661410011313	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
661410011314	dimerization interface [polypeptide binding]; other site
661410011315	metal binding site [ion binding]; metal-binding site
661410011316	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
661410011317	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410011318	dimer interface [polypeptide binding]; other site
661410011319	putative CheW interface [polypeptide binding]; other site
661410011320	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
661410011321	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410011322	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410011323	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
661410011324	dimerization interface [polypeptide binding]; other site
661410011325	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
661410011326	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
661410011327	GAF domain; Region: GAF_2; pfam13185
661410011328	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410011329	dimer interface [polypeptide binding]; other site
661410011330	phosphorylation site [posttranslational modification]
661410011331	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410011332	ATP binding site [chemical binding]; other site
661410011333	Mg2+ binding site [ion binding]; other site
661410011334	G-X-G motif; other site
661410011335	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410011336	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410011337	active site
661410011338	phosphorylation site [posttranslational modification]
661410011339	intermolecular recognition site; other site
661410011340	dimerization interface [polypeptide binding]; other site
661410011341	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
661410011342	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
661410011343	Domain of unknown function (DUF892); Region: DUF892; cl17410
661410011344	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
661410011345	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
661410011346	minor groove reading motif; other site
661410011347	helix-hairpin-helix signature motif; other site
661410011348	substrate binding pocket [chemical binding]; other site
661410011349	active site
661410011350	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
661410011351	short chain dehydrogenase; Provisional; Region: PRK06197
661410011352	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410011353	NAD(P) binding site [chemical binding]; other site
661410011354	active site
661410011355	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
661410011356	Fasciclin domain; Region: Fasciclin; pfam02469
661410011357	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
661410011358	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
661410011359	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
661410011360	Uncharacterized conserved protein [Function unknown]; Region: COG3791
661410011361	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410011362	GAF domain; Region: GAF; cl17456
661410011363	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
661410011364	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
661410011365	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410011366	dimer interface [polypeptide binding]; other site
661410011367	conserved gate region; other site
661410011368	putative PBP binding loops; other site
661410011369	ABC-ATPase subunit interface; other site
661410011370	Gram-negative bacterial tonB protein; Region: TonB; cl10048
661410011371	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
661410011372	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
661410011373	putative C-terminal domain interface [polypeptide binding]; other site
661410011374	putative GSH binding site (G-site) [chemical binding]; other site
661410011375	putative dimer interface [polypeptide binding]; other site
661410011376	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
661410011377	putative N-terminal domain interface [polypeptide binding]; other site
661410011378	putative dimer interface [polypeptide binding]; other site
661410011379	putative substrate binding pocket (H-site) [chemical binding]; other site
661410011380	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410011381	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
661410011382	Walker A/P-loop; other site
661410011383	ATP binding site [chemical binding]; other site
661410011384	Q-loop/lid; other site
661410011385	ABC transporter signature motif; other site
661410011386	Walker B; other site
661410011387	D-loop; other site
661410011388	H-loop/switch region; other site
661410011389	TOBE domain; Region: TOBE; cl01440
661410011390	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
661410011391	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
661410011392	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
661410011393	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
661410011394	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410011395	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410011396	PGAP1-like protein; Region: PGAP1; pfam07819
661410011397	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
661410011398	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
661410011399	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
661410011400	Sulfate transporter family; Region: Sulfate_transp; pfam00916
661410011401	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
661410011402	LrgB-like family; Region: LrgB; pfam04172
661410011403	LrgA family; Region: LrgA; pfam03788
661410011404	tellurium resistance terB-like protein; Region: terB_like; cl11965
661410011405	metal binding site [ion binding]; metal-binding site
661410011406	Methyltransferase domain; Region: Methyltransf_23; pfam13489
661410011407	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410011408	S-adenosylmethionine binding site [chemical binding]; other site
661410011409	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
661410011410	OstA-like protein; Region: OstA; cl00844
661410011411	Organic solvent tolerance protein; Region: OstA_C; pfam04453
661410011412	Predicted permeases [General function prediction only]; Region: COG0795
661410011413	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
661410011414	Predicted permeases [General function prediction only]; Region: COG0795
661410011415	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
661410011416	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
661410011417	multifunctional aminopeptidase A; Provisional; Region: PRK00913
661410011418	interface (dimer of trimers) [polypeptide binding]; other site
661410011419	Substrate-binding/catalytic site; other site
661410011420	Zn-binding sites [ion binding]; other site
661410011421	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
661410011422	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
661410011423	acyl-activating enzyme (AAE) consensus motif; other site
661410011424	putative AMP binding site [chemical binding]; other site
661410011425	putative active site [active]
661410011426	putative CoA binding site [chemical binding]; other site
661410011427	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
661410011428	Mechanosensitive ion channel; Region: MS_channel; pfam00924
661410011429	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
661410011430	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
661410011431	catalytic residues [active]
661410011432	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
661410011433	Zn2+ binding site [ion binding]; other site
661410011434	Mg2+ binding site [ion binding]; other site
661410011435	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
661410011436	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
661410011437	hypothetical protein; Provisional; Region: PRK08960
661410011438	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
661410011439	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410011440	homodimer interface [polypeptide binding]; other site
661410011441	catalytic residue [active]
661410011442	Protein of unknown function (DUF422); Region: DUF422; cl00991
661410011443	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
661410011444	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
661410011445	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
661410011446	AMIN domain; Region: AMIN; pfam11741
661410011447	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
661410011448	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
661410011449	active site
661410011450	metal binding site [ion binding]; metal-binding site
661410011451	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
661410011452	Transglycosylase; Region: Transgly; pfam00912
661410011453	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
661410011454	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
661410011455	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
661410011456	active site
661410011457	dimer interface [polypeptide binding]; other site
661410011458	non-prolyl cis peptide bond; other site
661410011459	insertion regions; other site
661410011460	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
661410011461	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
661410011462	Flavin binding site [chemical binding]; other site
661410011463	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
661410011464	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
661410011465	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
661410011466	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
661410011467	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
661410011468	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
661410011469	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
661410011470	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
661410011471	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
661410011472	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
661410011473	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
661410011474	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
661410011475	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
661410011476	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
661410011477	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
661410011478	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
661410011479	Ligand binding site; other site
661410011480	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
661410011481	DXD motif; other site
661410011482	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
661410011483	allophanate hydrolase; Provisional; Region: PRK08186
661410011484	Amidase; Region: Amidase; cl11426
661410011485	urea carboxylase; Region: urea_carbox; TIGR02712
661410011486	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
661410011487	ATP-grasp domain; Region: ATP-grasp_4; cl17255
661410011488	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
661410011489	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
661410011490	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
661410011491	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
661410011492	carboxyltransferase (CT) interaction site; other site
661410011493	biotinylation site [posttranslational modification]; other site
661410011494	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
661410011495	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
661410011496	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
661410011497	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
661410011498	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
661410011499	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
661410011500	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
661410011501	Creatinine amidohydrolase; Region: Creatininase; pfam02633
661410011502	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
661410011503	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
661410011504	Walker A/P-loop; other site
661410011505	ATP binding site [chemical binding]; other site
661410011506	Q-loop/lid; other site
661410011507	ABC transporter signature motif; other site
661410011508	Walker B; other site
661410011509	D-loop; other site
661410011510	H-loop/switch region; other site
661410011511	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
661410011512	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410011513	dimer interface [polypeptide binding]; other site
661410011514	conserved gate region; other site
661410011515	putative PBP binding loops; other site
661410011516	ABC-ATPase subunit interface; other site
661410011517	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
661410011518	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
661410011519	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
661410011520	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410011521	Walker A/P-loop; other site
661410011522	ATP binding site [chemical binding]; other site
661410011523	Q-loop/lid; other site
661410011524	ABC transporter signature motif; other site
661410011525	Walker B; other site
661410011526	D-loop; other site
661410011527	H-loop/switch region; other site
661410011528	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
661410011529	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410011530	dimer interface [polypeptide binding]; other site
661410011531	conserved gate region; other site
661410011532	putative PBP binding loops; other site
661410011533	ABC-ATPase subunit interface; other site
661410011534	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
661410011535	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
661410011536	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
661410011537	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
661410011538	conserved cys residue [active]
661410011539	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
661410011540	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
661410011541	hydroxyglutarate oxidase; Provisional; Region: PRK11728
661410011542	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
661410011543	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
661410011544	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
661410011545	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
661410011546	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
661410011547	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
661410011548	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
661410011549	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
661410011550	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
661410011551	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
661410011552	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
661410011553	putative deacylase active site [active]
661410011554	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
661410011555	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
661410011556	Electron transfer flavoprotein domain; Region: ETF; smart00893
661410011557	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
661410011558	Domain of unknown function (DUF3483); Region: DUF3483; pfam11982
661410011559	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
661410011560	4Fe-4S binding domain; Region: Fer4; cl02805
661410011561	Cysteine-rich domain; Region: CCG; pfam02754
661410011562	Cysteine-rich domain; Region: CCG; pfam02754
661410011563	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
661410011564	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
661410011565	putative active site [active]
661410011566	putative FMN binding site [chemical binding]; other site
661410011567	putative substrate binding site [chemical binding]; other site
661410011568	putative catalytic residue [active]
661410011569	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
661410011570	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
661410011571	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
661410011572	FAD binding pocket [chemical binding]; other site
661410011573	FAD binding motif [chemical binding]; other site
661410011574	phosphate binding motif [ion binding]; other site
661410011575	beta-alpha-beta structure motif; other site
661410011576	NAD binding pocket [chemical binding]; other site
661410011577	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
661410011578	catalytic loop [active]
661410011579	iron binding site [ion binding]; other site
661410011580	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
661410011581	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
661410011582	[2Fe-2S] cluster binding site [ion binding]; other site
661410011583	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
661410011584	putative alpha subunit interface [polypeptide binding]; other site
661410011585	putative active site [active]
661410011586	putative substrate binding site [chemical binding]; other site
661410011587	Fe binding site [ion binding]; other site
661410011588	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
661410011589	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
661410011590	active site
661410011591	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
661410011592	Phosphotransferase enzyme family; Region: APH; pfam01636
661410011593	active site
661410011594	ATP binding site [chemical binding]; other site
661410011595	substrate binding site [chemical binding]; other site
661410011596	dimer interface [polypeptide binding]; other site
661410011597	Phosphotransferase enzyme family; Region: APH; pfam01636
661410011598	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
661410011599	substrate binding site [chemical binding]; other site
661410011600	allantoate amidohydrolase; Reviewed; Region: PRK09290
661410011601	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
661410011602	active site
661410011603	metal binding site [ion binding]; metal-binding site
661410011604	dimer interface [polypeptide binding]; other site
661410011605	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
661410011606	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
661410011607	Walker A/P-loop; other site
661410011608	ATP binding site [chemical binding]; other site
661410011609	Q-loop/lid; other site
661410011610	ABC transporter signature motif; other site
661410011611	Walker B; other site
661410011612	D-loop; other site
661410011613	H-loop/switch region; other site
661410011614	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
661410011615	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
661410011616	Walker A/P-loop; other site
661410011617	ATP binding site [chemical binding]; other site
661410011618	Q-loop/lid; other site
661410011619	ABC transporter signature motif; other site
661410011620	Walker B; other site
661410011621	D-loop; other site
661410011622	H-loop/switch region; other site
661410011623	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
661410011624	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
661410011625	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410011626	dimer interface [polypeptide binding]; other site
661410011627	conserved gate region; other site
661410011628	putative PBP binding loops; other site
661410011629	ABC-ATPase subunit interface; other site
661410011630	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
661410011631	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410011632	dimer interface [polypeptide binding]; other site
661410011633	conserved gate region; other site
661410011634	putative PBP binding loops; other site
661410011635	ABC-ATPase subunit interface; other site
661410011636	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
661410011637	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
661410011638	Secretin and TonB N terminus short domain; Region: STN; smart00965
661410011639	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
661410011640	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
661410011641	N-terminal plug; other site
661410011642	ligand-binding site [chemical binding]; other site
661410011643	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
661410011644	FecR protein; Region: FecR; pfam04773
661410011645	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
661410011646	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
661410011647	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
661410011648	DNA binding residues [nucleotide binding]
661410011649	IucA / IucC family; Region: IucA_IucC; pfam04183
661410011650	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
661410011651	IucA / IucC family; Region: IucA_IucC; pfam04183
661410011652	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
661410011653	acyl-CoA synthetase; Validated; Region: PRK08308
661410011654	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
661410011655	acyl-activating enzyme (AAE) consensus motif; other site
661410011656	AMP binding site [chemical binding]; other site
661410011657	active site
661410011658	CoA binding site [chemical binding]; other site
661410011659	acyl carrier protein; Provisional; Region: PRK07639
661410011660	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
661410011661	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
661410011662	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
661410011663	putative acetyltransferase YhhY; Provisional; Region: PRK10140
661410011664	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
661410011665	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
661410011666	Coenzyme A binding pocket [chemical binding]; other site
661410011667	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
661410011668	TetR family transcriptional regulator; Provisional; Region: PRK14996
661410011669	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
661410011670	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
661410011671	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
661410011672	Membrane fusogenic activity; Region: BMFP; pfam04380
661410011673	osmolarity response regulator; Provisional; Region: ompR; PRK09468
661410011674	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410011675	active site
661410011676	phosphorylation site [posttranslational modification]
661410011677	intermolecular recognition site; other site
661410011678	dimerization interface [polypeptide binding]; other site
661410011679	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410011680	DNA binding site [nucleotide binding]
661410011681	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410011682	dimer interface [polypeptide binding]; other site
661410011683	phosphorylation site [posttranslational modification]
661410011684	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410011685	ATP binding site [chemical binding]; other site
661410011686	Mg2+ binding site [ion binding]; other site
661410011687	G-X-G motif; other site
661410011688	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410011689	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410011690	metal binding site [ion binding]; metal-binding site
661410011691	active site
661410011692	I-site; other site
661410011693	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
661410011694	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
661410011695	putative C-terminal domain interface [polypeptide binding]; other site
661410011696	putative GSH binding site (G-site) [chemical binding]; other site
661410011697	putative dimer interface [polypeptide binding]; other site
661410011698	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
661410011699	putative N-terminal domain interface [polypeptide binding]; other site
661410011700	putative substrate binding pocket (H-site) [chemical binding]; other site
661410011701	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
661410011702	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
661410011703	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
661410011704	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410011705	active site
661410011706	phosphorylation site [posttranslational modification]
661410011707	intermolecular recognition site; other site
661410011708	dimerization interface [polypeptide binding]; other site
661410011709	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
661410011710	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
661410011711	putative active site [active]
661410011712	putative dimer interface [polypeptide binding]; other site
661410011713	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
661410011714	hypothetical protein; Provisional; Region: PRK10621
661410011715	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
661410011716	putative active site [active]
661410011717	putative catalytic site [active]
661410011718	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
661410011719	putative active site [active]
661410011720	putative catalytic site [active]
661410011721	YGGT family; Region: YGGT; pfam02325
661410011722	integrase; Provisional; Region: int; PHA02601
661410011723	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
661410011724	active site
661410011725	DNA binding site [nucleotide binding]
661410011726	Int/Topo IB signature motif; other site
661410011727	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
661410011728	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
661410011729	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
661410011730	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
661410011731	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
661410011732	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
661410011733	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
661410011734	catalytic residues [active]
661410011735	catalytic nucleophile [active]
661410011736	Recombinase; Region: Recombinase; pfam07508
661410011737	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
661410011738	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
661410011739	active site
661410011740	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
661410011741	nucleotide binding site/active site [active]
661410011742	HIT family signature motif; other site
661410011743	catalytic residue [active]
661410011744	short chain dehydrogenase; Provisional; Region: PRK06179
661410011745	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
661410011746	NADP binding site [chemical binding]; other site
661410011747	active site
661410011748	steroid binding site; other site
661410011749	Transcriptional regulators [Transcription]; Region: MarR; COG1846
661410011750	MarR family; Region: MarR_2; pfam12802
661410011751	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
661410011752	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
661410011753	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410011754	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410011755	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410011756	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410011757	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
661410011758	putative effector binding pocket; other site
661410011759	putative dimerization interface [polypeptide binding]; other site
661410011760	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
661410011761	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
661410011762	active site
661410011763	catalytic tetrad [active]
661410011764	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410011765	GAF domain; Region: GAF; pfam01590
661410011766	PAS domain; Region: PAS_9; pfam13426
661410011767	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410011768	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410011769	metal binding site [ion binding]; metal-binding site
661410011770	active site
661410011771	I-site; other site
661410011772	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410011773	GAF domain; Region: GAF; pfam01590
661410011774	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410011775	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
661410011776	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
661410011777	dimerization interface [polypeptide binding]; other site
661410011778	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
661410011779	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
661410011780	Domain of unknown function DUF20; Region: UPF0118; pfam01594
661410011781	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
661410011782	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
661410011783	putative active site [active]
661410011784	heme pocket [chemical binding]; other site
661410011785	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
661410011786	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
661410011787	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
661410011788	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
661410011789	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
661410011790	DNA binding residues [nucleotide binding]
661410011791	dimerization interface [polypeptide binding]; other site
661410011792	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
661410011793	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
661410011794	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
661410011795	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
661410011796	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
661410011797	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
661410011798	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
661410011799	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
661410011800	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
661410011801	TAP-like protein; Region: Abhydrolase_4; pfam08386
661410011802	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410011803	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410011804	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
661410011805	dimerization interface [polypeptide binding]; other site
661410011806	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
661410011807	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410011808	GAF domain; Region: GAF; pfam01590
661410011809	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
661410011810	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410011811	non-specific DNA binding site [nucleotide binding]; other site
661410011812	salt bridge; other site
661410011813	sequence-specific DNA binding site [nucleotide binding]; other site
661410011814	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410011815	PAS domain; Region: PAS_9; pfam13426
661410011816	putative active site [active]
661410011817	heme pocket [chemical binding]; other site
661410011818	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410011819	PAS domain; Region: PAS_9; pfam13426
661410011820	putative active site [active]
661410011821	heme pocket [chemical binding]; other site
661410011822	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410011823	PAS domain; Region: PAS_9; pfam13426
661410011824	putative active site [active]
661410011825	heme pocket [chemical binding]; other site
661410011826	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410011827	dimer interface [polypeptide binding]; other site
661410011828	putative CheW interface [polypeptide binding]; other site
661410011829	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
661410011830	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
661410011831	protein binding site [polypeptide binding]; other site
661410011832	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
661410011833	protein binding site [polypeptide binding]; other site
661410011834	acid-resistance protein; Provisional; Region: PRK10208
661410011835	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
661410011836	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
661410011837	Cl- selectivity filter; other site
661410011838	Cl- binding residues [ion binding]; other site
661410011839	pore gating glutamate residue; other site
661410011840	dimer interface [polypeptide binding]; other site
661410011841	H+/Cl- coupling transport residue; other site
661410011842	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
661410011843	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410011844	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410011845	Protein of unknown function (DUF2474); Region: DUF2474; pfam10617
661410011846	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
661410011847	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
661410011848	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
661410011849	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
661410011850	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
661410011851	dimerization interface [polypeptide binding]; other site
661410011852	putative DNA binding site [nucleotide binding]; other site
661410011853	putative Zn2+ binding site [ion binding]; other site
661410011854	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
661410011855	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
661410011856	peroxiredoxin; Provisional; Region: PRK13189
661410011857	Putative phosphatase (DUF442); Region: DUF442; cl17385
661410011858	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
661410011859	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
661410011860	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
661410011861	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
661410011862	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
661410011863	putative metal binding site [ion binding]; other site
661410011864	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
661410011865	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
661410011866	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
661410011867	ABC-ATPase subunit  interface; other site
661410011868	dimer interface [polypeptide binding]; other site
661410011869	putative PBP binding regions; other site
661410011870	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
661410011871	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
661410011872	Walker A/P-loop; other site
661410011873	ATP binding site [chemical binding]; other site
661410011874	Q-loop/lid; other site
661410011875	ABC transporter signature motif; other site
661410011876	Walker B; other site
661410011877	D-loop; other site
661410011878	H-loop/switch region; other site
661410011879	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
661410011880	Moco binding site; other site
661410011881	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
661410011882	metal coordination site [ion binding]; other site
661410011883	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
661410011884	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
661410011885	S-adenosylmethionine binding site [chemical binding]; other site
661410011886	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
661410011887	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
661410011888	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
661410011889	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
661410011890	active site
661410011891	catalytic tetrad [active]
661410011892	Isochorismatase family; Region: Isochorismatase; pfam00857
661410011893	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
661410011894	catalytic triad [active]
661410011895	conserved cis-peptide bond; other site
661410011896	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410011897	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410011898	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
661410011899	TLC ATP/ADP transporter; Region: TLC; cl03940
661410011900	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
661410011901	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
661410011902	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
661410011903	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
661410011904	active site
661410011905	catalytic tetrad [active]
661410011906	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
661410011907	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
661410011908	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
661410011909	RNA binding surface [nucleotide binding]; other site
661410011910	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
661410011911	active site
661410011912	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
661410011913	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
661410011914	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
661410011915	dimerization interface [polypeptide binding]; other site
661410011916	putative DNA binding site [nucleotide binding]; other site
661410011917	putative Zn2+ binding site [ion binding]; other site
661410011918	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
661410011919	ArsC family; Region: ArsC; pfam03960
661410011920	catalytic residues [active]
661410011921	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
661410011922	arsenical-resistance protein; Region: acr3; TIGR00832
661410011923	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410011924	PAS domain; Region: PAS_9; pfam13426
661410011925	putative active site [active]
661410011926	heme pocket [chemical binding]; other site
661410011927	PAS fold; Region: PAS_7; pfam12860
661410011928	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410011929	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410011930	metal binding site [ion binding]; metal-binding site
661410011931	active site
661410011932	I-site; other site
661410011933	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410011934	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
661410011935	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
661410011936	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410011937	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
661410011938	NAD(P) binding site [chemical binding]; other site
661410011939	active site
661410011940	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
661410011941	nucleoside/Zn binding site; other site
661410011942	dimer interface [polypeptide binding]; other site
661410011943	catalytic motif [active]
661410011944	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
661410011945	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
661410011946	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
661410011947	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
661410011948	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
661410011949	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
661410011950	generic binding surface II; other site
661410011951	generic binding surface I; other site
661410011952	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
661410011953	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
661410011954	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
661410011955	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
661410011956	active site
661410011957	transcription elongation factor regulatory protein; Validated; Region: PRK06342
661410011958	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
661410011959	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
661410011960	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
661410011961	NADP binding site [chemical binding]; other site
661410011962	dimer interface [polypeptide binding]; other site
661410011963	Ferredoxin [Energy production and conversion]; Region: COG1146
661410011964	4Fe-4S binding domain; Region: Fer4; pfam00037
661410011965	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
661410011966	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
661410011967	RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500
661410011968	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
661410011969	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
661410011970	DNA binding residues [nucleotide binding]
661410011971	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
661410011972	Glucose inhibited division protein A; Region: GIDA; pfam01134
661410011973	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
661410011974	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
661410011975	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
661410011976	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
661410011977	protein binding site [polypeptide binding]; other site
661410011978	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
661410011979	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
661410011980	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
661410011981	DNA binding residues [nucleotide binding]
661410011982	Anti-sigma-K factor rskA; Region: RskA; pfam10099
661410011983	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
661410011984	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
661410011985	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
661410011986	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
661410011987	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
661410011988	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410011989	putative CheW interface [polypeptide binding]; other site
661410011990	Nitrate and nitrite sensing; Region: NIT; pfam08376
661410011991	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
661410011992	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410011993	dimer interface [polypeptide binding]; other site
661410011994	putative CheW interface [polypeptide binding]; other site
661410011995	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410011996	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410011997	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410011998	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
661410011999	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
661410012000	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
661410012001	active site
661410012002	phosphorylation site [posttranslational modification]
661410012003	intermolecular recognition site; other site
661410012004	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410012005	GAF domain; Region: GAF; pfam01590
661410012006	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410012007	PAS fold; Region: PAS_3; pfam08447
661410012008	putative active site [active]
661410012009	heme pocket [chemical binding]; other site
661410012010	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410012011	PAS fold; Region: PAS_3; pfam08447
661410012012	putative active site [active]
661410012013	heme pocket [chemical binding]; other site
661410012014	PAS domain S-box; Region: sensory_box; TIGR00229
661410012015	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410012016	putative active site [active]
661410012017	heme pocket [chemical binding]; other site
661410012018	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410012019	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410012020	HWE histidine kinase; Region: HWE_HK; pfam07536
661410012021	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410012022	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
661410012023	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
661410012024	non-specific DNA interactions [nucleotide binding]; other site
661410012025	DNA binding site [nucleotide binding]
661410012026	sequence specific DNA binding site [nucleotide binding]; other site
661410012027	putative cAMP binding site [chemical binding]; other site
661410012028	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
661410012029	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
661410012030	active site
661410012031	Protein of unknown function, DUF488; Region: DUF488; pfam04343
661410012032	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
661410012033	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
661410012034	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
661410012035	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
661410012036	NADP binding site [chemical binding]; other site
661410012037	dimer interface [polypeptide binding]; other site
661410012038	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
661410012039	Isochorismatase family; Region: Isochorismatase; pfam00857
661410012040	catalytic triad [active]
661410012041	metal binding site [ion binding]; metal-binding site
661410012042	conserved cis-peptide bond; other site
661410012043	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
661410012044	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410012045	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
661410012046	catalytic residue [active]
661410012047	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
661410012048	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
661410012049	glutamine binding [chemical binding]; other site
661410012050	catalytic triad [active]
661410012051	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
661410012052	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
661410012053	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
661410012054	addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384
661410012055	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
661410012056	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
661410012057	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
661410012058	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410012059	FeS/SAM binding site; other site
661410012060	Predicted membrane protein [Function unknown]; Region: COG4270
661410012061	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
661410012062	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
661410012063	homodimer interface [polypeptide binding]; other site
661410012064	metal binding site [ion binding]; metal-binding site
661410012065	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
661410012066	homodimer interface [polypeptide binding]; other site
661410012067	active site
661410012068	putative chemical substrate binding site [chemical binding]; other site
661410012069	metal binding site [ion binding]; metal-binding site
661410012070	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
661410012071	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
661410012072	active site
661410012073	nucleophile elbow; other site
661410012074	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
661410012075	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
661410012076	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410012077	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410012078	metal binding site [ion binding]; metal-binding site
661410012079	active site
661410012080	I-site; other site
661410012081	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410012082	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410012083	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
661410012084	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
661410012085	Zn2+ binding site [ion binding]; other site
661410012086	Mg2+ binding site [ion binding]; other site
661410012087	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
661410012088	oligomer interface [polypeptide binding]; other site
661410012089	putative active site [active]
661410012090	Mn binding site [ion binding]; other site
661410012091	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
661410012092	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
661410012093	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
661410012094	Flavoprotein; Region: Flavoprotein; pfam02441
661410012095	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
661410012096	Uncharacterized conserved protein [Function unknown]; Region: COG4748
661410012097	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
661410012098	ABC1 family; Region: ABC1; cl17513
661410012099	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
661410012100	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
661410012101	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410012102	S-adenosylmethionine binding site [chemical binding]; other site
661410012103	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
661410012104	folate binding site [chemical binding]; other site
661410012105	NADP+ binding site [chemical binding]; other site
661410012106	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
661410012107	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410012108	NAD(P) binding site [chemical binding]; other site
661410012109	active site
661410012110	amidophosphoribosyltransferase; Provisional; Region: PRK09123
661410012111	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
661410012112	active site
661410012113	tetramer interface [polypeptide binding]; other site
661410012114	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
661410012115	active site
661410012116	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
661410012117	Colicin V production protein; Region: Colicin_V; pfam02674
661410012118	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
661410012119	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
661410012120	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
661410012121	Cu(I) binding site [ion binding]; other site
661410012122	DNA repair protein RadA; Provisional; Region: PRK11823
661410012123	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
661410012124	Walker A motif/ATP binding site; other site
661410012125	ATP binding site [chemical binding]; other site
661410012126	Walker B motif; other site
661410012127	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
661410012128	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
661410012129	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
661410012130	active site
661410012131	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
661410012132	dimer interface [polypeptide binding]; other site
661410012133	substrate binding site [chemical binding]; other site
661410012134	catalytic residues [active]
661410012135	replicative DNA helicase; Provisional; Region: PRK09165
661410012136	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
661410012137	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
661410012138	Walker A motif; other site
661410012139	ATP binding site [chemical binding]; other site
661410012140	Walker B motif; other site
661410012141	DNA binding loops [nucleotide binding]
661410012142	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
661410012143	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
661410012144	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
661410012145	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
661410012146	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
661410012147	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
661410012148	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
661410012149	Coenzyme A binding pocket [chemical binding]; other site
661410012150	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
661410012151	pentamer interface [polypeptide binding]; other site
661410012152	dodecaamer interface [polypeptide binding]; other site
661410012153	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
661410012154	DNA-binding site [nucleotide binding]; DNA binding site
661410012155	RNA-binding motif; other site
661410012156	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
661410012157	active site
661410012158	catalytic residues [active]
661410012159	metal binding site [ion binding]; metal-binding site
661410012160	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
661410012161	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
661410012162	Protein of unknown function (DUF3750); Region: DUF3750; pfam12570
661410012163	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
661410012164	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
661410012165	Coenzyme A binding pocket [chemical binding]; other site
661410012166	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
661410012167	fructuronate transporter; Provisional; Region: PRK10034; cl15264
661410012168	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
661410012169	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
661410012170	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
661410012171	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
661410012172	NAD(P) binding site [chemical binding]; other site
661410012173	active site
661410012174	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
661410012175	Aspartase; Region: Aspartase; cd01357
661410012176	active sites [active]
661410012177	tetramer interface [polypeptide binding]; other site
661410012178	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
661410012179	Porin subfamily; Region: Porin_2; pfam02530
661410012180	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
661410012181	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
661410012182	substrate binding pocket [chemical binding]; other site
661410012183	membrane-bound complex binding site; other site
661410012184	hinge residues; other site
661410012185	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
661410012186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410012187	dimer interface [polypeptide binding]; other site
661410012188	conserved gate region; other site
661410012189	putative PBP binding loops; other site
661410012190	ABC-ATPase subunit interface; other site
661410012191	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
661410012192	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410012193	dimer interface [polypeptide binding]; other site
661410012194	conserved gate region; other site
661410012195	putative PBP binding loops; other site
661410012196	ABC-ATPase subunit interface; other site
661410012197	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
661410012198	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
661410012199	Walker A/P-loop; other site
661410012200	ATP binding site [chemical binding]; other site
661410012201	Q-loop/lid; other site
661410012202	ABC transporter signature motif; other site
661410012203	Walker B; other site
661410012204	D-loop; other site
661410012205	H-loop/switch region; other site
661410012206	Protein of unknown function, DUF606; Region: DUF606; pfam04657
661410012207	Protein of unknown function, DUF606; Region: DUF606; pfam04657
661410012208	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
661410012209	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
661410012210	transmembrane helices; other site
661410012211	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
661410012212	nudix motif; other site
661410012213	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
661410012214	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cd02106
661410012215	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
661410012216	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
661410012217	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
661410012218	acyl-activating enzyme (AAE) consensus motif; other site
661410012219	AMP binding site [chemical binding]; other site
661410012220	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
661410012221	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
661410012222	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
661410012223	putative trimer interface [polypeptide binding]; other site
661410012224	putative CoA binding site [chemical binding]; other site
661410012225	Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309
661410012226	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
661410012227	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
661410012228	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
661410012229	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
661410012230	catalytic residue [active]
661410012231	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
661410012232	putative ABC transporter; Region: ycf24; CHL00085
661410012233	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
661410012234	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
661410012235	Walker A/P-loop; other site
661410012236	ATP binding site [chemical binding]; other site
661410012237	Q-loop/lid; other site
661410012238	ABC transporter signature motif; other site
661410012239	Walker B; other site
661410012240	D-loop; other site
661410012241	H-loop/switch region; other site
661410012242	FeS assembly protein SufD; Region: sufD; TIGR01981
661410012243	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
661410012244	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
661410012245	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
661410012246	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
661410012247	catalytic residue [active]
661410012248	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
661410012249	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
661410012250	putative active site [active]
661410012251	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
661410012252	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410012253	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410012254	metal binding site [ion binding]; metal-binding site
661410012255	active site
661410012256	I-site; other site
661410012257	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
661410012258	DEAD-like helicases superfamily; Region: DEXDc; smart00487
661410012259	ATP binding site [chemical binding]; other site
661410012260	Mg++ binding site [ion binding]; other site
661410012261	motif III; other site
661410012262	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
661410012263	nucleotide binding region [chemical binding]; other site
661410012264	ATP-binding site [chemical binding]; other site
661410012265	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
661410012266	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
661410012267	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
661410012268	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
661410012269	motif II; other site
661410012270	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
661410012271	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
661410012272	Walker A/P-loop; other site
661410012273	ATP binding site [chemical binding]; other site
661410012274	Q-loop/lid; other site
661410012275	ABC transporter signature motif; other site
661410012276	Walker B; other site
661410012277	D-loop; other site
661410012278	H-loop/switch region; other site
661410012279	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
661410012280	active site
661410012281	catalytic triad [active]
661410012282	oxyanion hole [active]
661410012283	switch loop; other site
661410012284	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
661410012285	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
661410012286	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
661410012287	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
661410012288	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
661410012289	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
661410012290	putative homodimer interface [polypeptide binding]; other site
661410012291	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
661410012292	heterodimer interface [polypeptide binding]; other site
661410012293	homodimer interface [polypeptide binding]; other site
661410012294	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
661410012295	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
661410012296	23S rRNA interface [nucleotide binding]; other site
661410012297	L7/L12 interface [polypeptide binding]; other site
661410012298	putative thiostrepton binding site; other site
661410012299	L25 interface [polypeptide binding]; other site
661410012300	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
661410012301	mRNA/rRNA interface [nucleotide binding]; other site
661410012302	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
661410012303	Cytochrome P450; Region: p450; cl12078
661410012304	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
661410012305	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
661410012306	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
661410012307	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
661410012308	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
661410012309	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
661410012310	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
661410012311	Probable Catalytic site; other site
661410012312	metal-binding site
661410012313	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
661410012314	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
661410012315	dimer interface [polypeptide binding]; other site
661410012316	anticodon binding site; other site
661410012317	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
661410012318	motif 1; other site
661410012319	dimer interface [polypeptide binding]; other site
661410012320	active site
661410012321	motif 2; other site
661410012322	GAD domain; Region: GAD; pfam02938
661410012323	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
661410012324	active site
661410012325	motif 3; other site
661410012326	biotin synthase; Region: bioB; TIGR00433
661410012327	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410012328	FeS/SAM binding site; other site
661410012329	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
661410012330	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
661410012331	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
661410012332	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
661410012333	arogenate dehydrogenase; Region: PLN02256
661410012334	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
661410012335	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
661410012336	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
661410012337	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410012338	PAS domain; Region: PAS_9; pfam13426
661410012339	putative active site [active]
661410012340	heme pocket [chemical binding]; other site
661410012341	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410012342	metal binding site [ion binding]; metal-binding site
661410012343	active site
661410012344	I-site; other site
661410012345	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410012346	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
661410012347	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
661410012348	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
661410012349	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
661410012350	23S rRNA interface [nucleotide binding]; other site
661410012351	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
661410012352	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
661410012353	L11 interface [polypeptide binding]; other site
661410012354	putative EF-Tu interaction site [polypeptide binding]; other site
661410012355	putative EF-G interaction site [polypeptide binding]; other site
661410012356	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
661410012357	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
661410012358	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
661410012359	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
661410012360	RPB11 interaction site [polypeptide binding]; other site
661410012361	RPB12 interaction site [polypeptide binding]; other site
661410012362	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
661410012363	RPB3 interaction site [polypeptide binding]; other site
661410012364	RPB1 interaction site [polypeptide binding]; other site
661410012365	RPB11 interaction site [polypeptide binding]; other site
661410012366	RPB10 interaction site [polypeptide binding]; other site
661410012367	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
661410012368	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
661410012369	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
661410012370	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
661410012371	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
661410012372	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
661410012373	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
661410012374	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
661410012375	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
661410012376	DNA binding site [nucleotide binding]
661410012377	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
661410012378	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
661410012379	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
661410012380	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
661410012381	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
661410012382	homotrimer interaction site [polypeptide binding]; other site
661410012383	putative active site [active]
661410012384	Predicted membrane protein [Function unknown]; Region: COG2261
661410012385	Predicted transcriptional regulators [Transcription]; Region: COG1733
661410012386	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
661410012387	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
661410012388	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
661410012389	putative C-terminal domain interface [polypeptide binding]; other site
661410012390	putative GSH binding site (G-site) [chemical binding]; other site
661410012391	putative dimer interface [polypeptide binding]; other site
661410012392	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
661410012393	dimer interface [polypeptide binding]; other site
661410012394	N-terminal domain interface [polypeptide binding]; other site
661410012395	putative substrate binding pocket (H-site) [chemical binding]; other site
661410012396	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
661410012397	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
661410012398	N-terminal plug; other site
661410012399	ligand-binding site [chemical binding]; other site
661410012400	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
661410012401	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
661410012402	RNase E interface [polypeptide binding]; other site
661410012403	trimer interface [polypeptide binding]; other site
661410012404	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
661410012405	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
661410012406	RNase E interface [polypeptide binding]; other site
661410012407	trimer interface [polypeptide binding]; other site
661410012408	active site
661410012409	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
661410012410	putative nucleic acid binding region [nucleotide binding]; other site
661410012411	G-X-X-G motif; other site
661410012412	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
661410012413	RNA binding site [nucleotide binding]; other site
661410012414	domain interface; other site
661410012415	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
661410012416	16S/18S rRNA binding site [nucleotide binding]; other site
661410012417	S13e-L30e interaction site [polypeptide binding]; other site
661410012418	25S rRNA binding site [nucleotide binding]; other site
661410012419	amino acid transporter; Region: 2A0306; TIGR00909
661410012420	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
661410012421	putative catalytic site [active]
661410012422	putative phosphate binding site [ion binding]; other site
661410012423	active site
661410012424	metal binding site A [ion binding]; metal-binding site
661410012425	DNA binding site [nucleotide binding]
661410012426	putative AP binding site [nucleotide binding]; other site
661410012427	putative metal binding site B [ion binding]; other site
661410012428	Sensors of blue-light using FAD; Region: BLUF; pfam04940
661410012429	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
661410012430	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
661410012431	metal binding site [ion binding]; metal-binding site
661410012432	active site
661410012433	I-site; other site
661410012434	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
661410012435	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
661410012436	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
661410012437	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
661410012438	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
661410012439	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
661410012440	NAD synthetase; Reviewed; Region: nadE; PRK02628
661410012441	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
661410012442	multimer interface [polypeptide binding]; other site
661410012443	active site
661410012444	catalytic triad [active]
661410012445	protein interface 1 [polypeptide binding]; other site
661410012446	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
661410012447	homodimer interface [polypeptide binding]; other site
661410012448	NAD binding pocket [chemical binding]; other site
661410012449	ATP binding pocket [chemical binding]; other site
661410012450	Mg binding site [ion binding]; other site
661410012451	active-site loop [active]
661410012452	response regulator; Provisional; Region: PRK13435
661410012453	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410012454	active site
661410012455	phosphorylation site [posttranslational modification]
661410012456	intermolecular recognition site; other site
661410012457	dimerization interface [polypeptide binding]; other site
661410012458	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410012459	PAS domain; Region: PAS_9; pfam13426
661410012460	putative active site [active]
661410012461	heme pocket [chemical binding]; other site
661410012462	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410012463	Histidine kinase; Region: HisKA_2; pfam07568
661410012464	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410012465	ATP binding site [chemical binding]; other site
661410012466	Mg2+ binding site [ion binding]; other site
661410012467	G-X-G motif; other site
661410012468	muropeptide transporter; Validated; Region: ampG; cl17669
661410012469	EcsC protein family; Region: EcsC; pfam12787
661410012470	NnrU protein; Region: NnrU; pfam07298
661410012471	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
661410012472	GTP-binding protein Der; Reviewed; Region: PRK00093
661410012473	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
661410012474	G1 box; other site
661410012475	GTP/Mg2+ binding site [chemical binding]; other site
661410012476	Switch I region; other site
661410012477	G2 box; other site
661410012478	Switch II region; other site
661410012479	G3 box; other site
661410012480	G4 box; other site
661410012481	G5 box; other site
661410012482	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
661410012483	G1 box; other site
661410012484	GTP/Mg2+ binding site [chemical binding]; other site
661410012485	Switch I region; other site
661410012486	G2 box; other site
661410012487	G3 box; other site
661410012488	Switch II region; other site
661410012489	G4 box; other site
661410012490	G5 box; other site
661410012491	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
661410012492	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
661410012493	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
661410012494	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
661410012495	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
661410012496	DNA binding site [nucleotide binding]
661410012497	catalytic residue [active]
661410012498	H2TH interface [polypeptide binding]; other site
661410012499	putative catalytic residues [active]
661410012500	turnover-facilitating residue; other site
661410012501	intercalation triad [nucleotide binding]; other site
661410012502	8OG recognition residue [nucleotide binding]; other site
661410012503	putative reading head residues; other site
661410012504	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
661410012505	Predicted transcriptional regulator [Transcription]; Region: COG1959
661410012506	Transcriptional regulator; Region: Rrf2; pfam02082
661410012507	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
661410012508	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
661410012509	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
661410012510	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
661410012511	Beta-lactamase; Region: Beta-lactamase; pfam00144
661410012512	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
661410012513	PAS fold; Region: PAS_4; pfam08448
661410012514	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
661410012515	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410012516	putative active site [active]
661410012517	heme pocket [chemical binding]; other site
661410012518	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410012519	dimer interface [polypeptide binding]; other site
661410012520	phosphorylation site [posttranslational modification]
661410012521	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410012522	ATP binding site [chemical binding]; other site
661410012523	Mg2+ binding site [ion binding]; other site
661410012524	G-X-G motif; other site
661410012525	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410012526	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410012527	active site
661410012528	phosphorylation site [posttranslational modification]
661410012529	intermolecular recognition site; other site
661410012530	dimerization interface [polypeptide binding]; other site
661410012531	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
661410012532	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
661410012533	GSH binding site (G-site) [chemical binding]; other site
661410012534	C-terminal domain interface [polypeptide binding]; other site
661410012535	dimer interface [polypeptide binding]; other site
661410012536	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
661410012537	dimer interface [polypeptide binding]; other site
661410012538	N-terminal domain interface [polypeptide binding]; other site
661410012539	substrate binding pocket (H-site) [chemical binding]; other site
661410012540	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
661410012541	excinuclease ABC subunit B; Provisional; Region: PRK05298
661410012542	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
661410012543	ATP binding site [chemical binding]; other site
661410012544	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
661410012545	nucleotide binding region [chemical binding]; other site
661410012546	ATP-binding site [chemical binding]; other site
661410012547	Ultra-violet resistance protein B; Region: UvrB; pfam12344
661410012548	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
661410012549	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
661410012550	putative active site [active]
661410012551	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410012552	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410012553	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
661410012554	putative effector binding pocket; other site
661410012555	dimerization interface [polypeptide binding]; other site
661410012556	Predicted membrane protein [Function unknown]; Region: COG2259
661410012557	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
661410012558	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
661410012559	putative metal binding site [ion binding]; other site
661410012560	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
661410012561	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14839
661410012562	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
661410012563	catalytic residue [active]
661410012564	putative FPP diphosphate  binding site; other site
661410012565	putative FPP binding hydrophobic cleft; other site
661410012566	dimer interface [polypeptide binding]; other site
661410012567	putative IPP diphosphate binding site; other site
661410012568	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
661410012569	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
661410012570	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
661410012571	FeS/SAM binding site; other site
661410012572	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
661410012573	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
661410012574	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
661410012575	glycerol kinase; Provisional; Region: glpK; PRK00047
661410012576	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
661410012577	N- and C-terminal domain interface [polypeptide binding]; other site
661410012578	active site
661410012579	MgATP binding site [chemical binding]; other site
661410012580	catalytic site [active]
661410012581	metal binding site [ion binding]; metal-binding site
661410012582	putative homotetramer interface [polypeptide binding]; other site
661410012583	glycerol binding site [chemical binding]; other site
661410012584	homodimer interface [polypeptide binding]; other site
661410012585	hypothetical protein; Provisional; Region: PRK06489
661410012586	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
661410012587	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
661410012588	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410012589	dimer interface [polypeptide binding]; other site
661410012590	putative CheW interface [polypeptide binding]; other site
661410012591	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
661410012592	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
661410012593	active site
661410012594	catalytic site [active]
661410012595	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
661410012596	homotrimer interaction site [polypeptide binding]; other site
661410012597	putative active site [active]
661410012598	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
661410012599	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
661410012600	putative active site [active]
661410012601	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
661410012602	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
661410012603	Walker A/P-loop; other site
661410012604	ATP binding site [chemical binding]; other site
661410012605	Q-loop/lid; other site
661410012606	ABC transporter signature motif; other site
661410012607	Walker B; other site
661410012608	D-loop; other site
661410012609	H-loop/switch region; other site
661410012610	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
661410012611	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
661410012612	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410012613	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
661410012614	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
661410012615	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
661410012616	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
661410012617	inhibitor-cofactor binding pocket; inhibition site
661410012618	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410012619	catalytic residue [active]
661410012620	ornithine carbamoyltransferase; Provisional; Region: PRK00779
661410012621	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
661410012622	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
661410012623	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
661410012624	putative hydrophobic ligand binding site [chemical binding]; other site
661410012625	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
661410012626	putative dimer interface [polypeptide binding]; other site
661410012627	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
661410012628	short chain dehydrogenase; Provisional; Region: PRK06523
661410012629	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410012630	NAD(P) binding site [chemical binding]; other site
661410012631	active site
661410012632	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
661410012633	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
661410012634	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
661410012635	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
661410012636	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410012637	putative active site [active]
661410012638	heme pocket [chemical binding]; other site
661410012639	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
661410012640	GAF domain; Region: GAF; pfam01590
661410012641	Phytochrome region; Region: PHY; pfam00360
661410012642	Histidine kinase; Region: HisKA_2; pfam07568
661410012643	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410012644	ATP binding site [chemical binding]; other site
661410012645	Mg2+ binding site [ion binding]; other site
661410012646	G-X-G motif; other site
661410012647	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
661410012648	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
661410012649	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
661410012650	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
661410012651	PAP2 superfamily; Region: PAP2_3; pfam14378
661410012652	active site
661410012653	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
661410012654	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410012655	Walker A motif; other site
661410012656	ATP binding site [chemical binding]; other site
661410012657	Walker B motif; other site
661410012658	arginine finger; other site
661410012659	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
661410012660	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
661410012661	flagellar assembly protein H; Validated; Region: fliH; PRK06032
661410012662	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
661410012663	FliG C-terminal domain; Region: FliG_C; pfam01706
661410012664	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
661410012665	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
661410012666	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
661410012667	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
661410012668	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
661410012669	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
661410012670	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
661410012671	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
661410012672	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
661410012673	Ligand Binding Site [chemical binding]; other site
661410012674	Methyltransferase domain; Region: Methyltransf_31; pfam13847
661410012675	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410012676	S-adenosylmethionine binding site [chemical binding]; other site
661410012677	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
661410012678	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410012679	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410012680	ATP binding site [chemical binding]; other site
661410012681	Mg2+ binding site [ion binding]; other site
661410012682	G-X-G motif; other site
661410012683	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
661410012684	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410012685	putative substrate translocation pore; other site
661410012686	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
661410012687	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410012688	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410012689	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
661410012690	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
661410012691	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
661410012692	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
661410012693	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
661410012694	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
661410012695	active site
661410012696	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
661410012697	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
661410012698	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
661410012699	PAS domain; Region: PAS; smart00091
661410012700	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410012701	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410012702	dimer interface [polypeptide binding]; other site
661410012703	phosphorylation site [posttranslational modification]
661410012704	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410012705	ATP binding site [chemical binding]; other site
661410012706	Mg2+ binding site [ion binding]; other site
661410012707	G-X-G motif; other site
661410012708	Response regulator receiver domain; Region: Response_reg; pfam00072
661410012709	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410012710	active site
661410012711	phosphorylation site [posttranslational modification]
661410012712	intermolecular recognition site; other site
661410012713	dimerization interface [polypeptide binding]; other site
661410012714	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
661410012715	tetramer interface [polypeptide binding]; other site
661410012716	dimer interface [polypeptide binding]; other site
661410012717	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
661410012718	tetramer interface [polypeptide binding]; other site
661410012719	dimer interface [polypeptide binding]; other site
661410012720	circadian clock protein KaiC; Reviewed; Region: PRK09302
661410012721	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
661410012722	Walker A motif; other site
661410012723	ATP binding site [chemical binding]; other site
661410012724	Walker B motif; other site
661410012725	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
661410012726	Walker A motif; other site
661410012727	ATP binding site [chemical binding]; other site
661410012728	Walker B motif; other site
661410012729	Response regulator receiver domain; Region: Response_reg; pfam00072
661410012730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410012731	active site
661410012732	phosphorylation site [posttranslational modification]
661410012733	intermolecular recognition site; other site
661410012734	dimerization interface [polypeptide binding]; other site
661410012735	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410012736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410012737	ATP binding site [chemical binding]; other site
661410012738	Mg2+ binding site [ion binding]; other site
661410012739	G-X-G motif; other site
661410012740	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
661410012741	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410012742	active site
661410012743	phosphorylation site [posttranslational modification]
661410012744	intermolecular recognition site; other site
661410012745	dimerization interface [polypeptide binding]; other site
661410012746	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410012747	DNA binding site [nucleotide binding]
661410012748	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
661410012749	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
661410012750	Staphylococcal nuclease homologues; Region: SNc; smart00318
661410012751	Catalytic site; other site
661410012752	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
661410012753	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
661410012754	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
661410012755	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
661410012756	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
661410012757	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
661410012758	N-terminal plug; other site
661410012759	ligand-binding site [chemical binding]; other site
661410012760	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
661410012761	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
661410012762	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
661410012763	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
661410012764	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
661410012765	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
661410012766	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
661410012767	active site
661410012768	substrate binding site [chemical binding]; other site
661410012769	metal binding site [ion binding]; metal-binding site
661410012770	Right handed beta helix region; Region: Beta_helix; pfam13229
661410012771	Right handed beta helix region; Region: Beta_helix; pfam13229
661410012772	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
661410012773	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
661410012774	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
661410012775	Bacterial sugar transferase; Region: Bac_transf; pfam02397
661410012776	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410012777	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
661410012778	NAD(P) binding site [chemical binding]; other site
661410012779	active site
661410012780	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
661410012781	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
661410012782	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
661410012783	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
661410012784	NAD binding site [chemical binding]; other site
661410012785	putative substrate binding site 2 [chemical binding]; other site
661410012786	putative substrate binding site 1 [chemical binding]; other site
661410012787	active site
661410012788	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
661410012789	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
661410012790	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
661410012791	Substrate binding site; other site
661410012792	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
661410012793	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
661410012794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410012795	active site
661410012796	phosphorylation site [posttranslational modification]
661410012797	intermolecular recognition site; other site
661410012798	dimerization interface [polypeptide binding]; other site
661410012799	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
661410012800	DNA binding residues [nucleotide binding]
661410012801	dimerization interface [polypeptide binding]; other site
661410012802	Uncharacterized conserved protein [Function unknown]; Region: COG3391
661410012803	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
661410012804	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
661410012805	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
661410012806	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
661410012807	putative hydrophobic ligand binding site [chemical binding]; other site
661410012808	protein interface [polypeptide binding]; other site
661410012809	gate; other site
661410012810	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
661410012811	metal ion-dependent adhesion site (MIDAS); other site
661410012812	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
661410012813	metal ion-dependent adhesion site (MIDAS); other site
661410012814	Protein of unknown function DUF58; Region: DUF58; pfam01882
661410012815	MoxR-like ATPases [General function prediction only]; Region: COG0714
661410012816	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410012817	Walker A motif; other site
661410012818	ATP binding site [chemical binding]; other site
661410012819	Walker B motif; other site
661410012820	arginine finger; other site
661410012821	Methanol dehydrogenase beta subunit; Region: MDH; pfam02315
661410012822	cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872
661410012823	methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870
661410012824	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
661410012825	substrate binding pocket [chemical binding]; other site
661410012826	membrane-bound complex binding site; other site
661410012827	hinge residues; other site
661410012828	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
661410012829	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
661410012830	Trp docking motif [polypeptide binding]; other site
661410012831	dimer interface [polypeptide binding]; other site
661410012832	active site
661410012833	small subunit binding site [polypeptide binding]; other site
661410012834	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
661410012835	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
661410012836	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
661410012837	Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002
661410012838	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
661410012839	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
661410012840	Substrate binding site; other site
661410012841	Mg++ binding site; other site
661410012842	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
661410012843	putative trimer interface [polypeptide binding]; other site
661410012844	putative CoA binding site [chemical binding]; other site
661410012845	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
661410012846	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
661410012847	glutaminase active site [active]
661410012848	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
661410012849	dimer interface [polypeptide binding]; other site
661410012850	active site
661410012851	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
661410012852	dimer interface [polypeptide binding]; other site
661410012853	active site
661410012854	Domain of unknown function (DUF336); Region: DUF336; pfam03928
661410012855	Uncharacterized conserved protein [Function unknown]; Region: COG2928
661410012856	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
661410012857	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
661410012858	generic binding surface II; other site
661410012859	ssDNA binding site; other site
661410012860	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
661410012861	ATP binding site [chemical binding]; other site
661410012862	putative Mg++ binding site [ion binding]; other site
661410012863	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
661410012864	nucleotide binding region [chemical binding]; other site
661410012865	ATP-binding site [chemical binding]; other site
661410012866	Uncharacterized conserved protein [Function unknown]; Region: COG2938
661410012867	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
661410012868	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
661410012869	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
661410012870	ATP binding site [chemical binding]; other site
661410012871	putative Mg++ binding site [ion binding]; other site
661410012872	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
661410012873	nucleotide binding region [chemical binding]; other site
661410012874	ATP-binding site [chemical binding]; other site
661410012875	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
661410012876	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
661410012877	DNA-binding site [nucleotide binding]; DNA binding site
661410012878	RNA-binding motif; other site
661410012879	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
661410012880	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
661410012881	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
661410012882	dimer interface [polypeptide binding]; other site
661410012883	phosphorylation site [posttranslational modification]
661410012884	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410012885	ATP binding site [chemical binding]; other site
661410012886	Mg2+ binding site [ion binding]; other site
661410012887	G-X-G motif; other site
661410012888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410012889	active site
661410012890	phosphorylation site [posttranslational modification]
661410012891	intermolecular recognition site; other site
661410012892	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
661410012893	acyl-CoA synthetase; Validated; Region: PRK08162
661410012894	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
661410012895	acyl-activating enzyme (AAE) consensus motif; other site
661410012896	putative active site [active]
661410012897	AMP binding site [chemical binding]; other site
661410012898	putative CoA binding site [chemical binding]; other site
661410012899	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
661410012900	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
661410012901	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
661410012902	Ligand binding site; other site
661410012903	Putative Catalytic site; other site
661410012904	DXD motif; other site
661410012905	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
661410012906	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
661410012907	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
661410012908	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
661410012909	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
661410012910	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
661410012911	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410012912	NAD(P) binding site [chemical binding]; other site
661410012913	active site
661410012914	hypothetical protein; Validated; Region: PRK00029
661410012915	Uncharacterized conserved protein [Function unknown]; Region: COG0397
661410012916	Protein of unknown function (DUF433); Region: DUF433; pfam04255
661410012917	EamA-like transporter family; Region: EamA; pfam00892
661410012918	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
661410012919	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410012920	Histidine kinase; Region: HisKA_2; pfam07568
661410012921	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410012922	ATP binding site [chemical binding]; other site
661410012923	Mg2+ binding site [ion binding]; other site
661410012924	G-X-G motif; other site
661410012925	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
661410012926	active site
661410012927	oxyanion hole [active]
661410012928	catalytic triad [active]
661410012929	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
661410012930	heme-binding site [chemical binding]; other site
661410012931	putative hydrolase; Provisional; Region: PRK02113
661410012932	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
661410012933	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
661410012934	active site
661410012935	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
661410012936	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
661410012937	active site
661410012938	HIGH motif; other site
661410012939	KMSKS motif; other site
661410012940	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
661410012941	tRNA binding surface [nucleotide binding]; other site
661410012942	anticodon binding site; other site
661410012943	DNA polymerase III subunit delta'; Validated; Region: PRK07471
661410012944	DNA polymerase III subunit delta'; Validated; Region: PRK08485
661410012945	thymidylate kinase; Validated; Region: tmk; PRK00698
661410012946	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
661410012947	TMP-binding site; other site
661410012948	ATP-binding site [chemical binding]; other site
661410012949	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
661410012950	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410012951	dimer interface [polypeptide binding]; other site
661410012952	conserved gate region; other site
661410012953	putative PBP binding loops; other site
661410012954	ABC-ATPase subunit interface; other site
661410012955	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
661410012956	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
661410012957	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410012958	Walker A/P-loop; other site
661410012959	ATP binding site [chemical binding]; other site
661410012960	Q-loop/lid; other site
661410012961	ABC transporter signature motif; other site
661410012962	Walker B; other site
661410012963	D-loop; other site
661410012964	H-loop/switch region; other site
661410012965	TOBE domain; Region: TOBE_2; pfam08402
661410012966	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410012967	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
661410012968	ligand binding site [chemical binding]; other site
661410012969	flexible hinge region; other site
661410012970	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
661410012971	Predicted membrane protein [Function unknown]; Region: COG5373
661410012972	Predicted membrane protein [Function unknown]; Region: COG5373
661410012973	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410012974	D-galactonate transporter; Region: 2A0114; TIGR00893
661410012975	putative substrate translocation pore; other site
661410012976	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
661410012977	homodimer interface [polypeptide binding]; other site
661410012978	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410012979	catalytic residue [active]
661410012980	Transcriptional regulators [Transcription]; Region: GntR; COG1802
661410012981	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
661410012982	DNA-binding site [nucleotide binding]; DNA binding site
661410012983	FCD domain; Region: FCD; pfam07729
661410012984	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
661410012985	short chain dehydrogenase; Provisional; Region: PRK06701
661410012986	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
661410012987	NAD binding site [chemical binding]; other site
661410012988	metal binding site [ion binding]; metal-binding site
661410012989	active site
661410012990	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
661410012991	FAD binding domain; Region: FAD_binding_4; pfam01565
661410012992	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
661410012993	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
661410012994	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
661410012995	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
661410012996	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
661410012997	tetramerization interface [polypeptide binding]; other site
661410012998	NAD(P) binding site [chemical binding]; other site
661410012999	catalytic residues [active]
661410013000	Hint domain; Region: Hint_2; pfam13403
661410013001	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
661410013002	Chain length determinant protein; Region: Wzz; pfam02706
661410013003	O-Antigen ligase; Region: Wzy_C; pfam04932
661410013004	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
661410013005	lipoate-protein ligase B; Provisional; Region: PRK14341
661410013006	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
661410013007	active site
661410013008	Protein of unknown function, DUF606; Region: DUF606; pfam04657
661410013009	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
661410013010	Domain of unknown function DUF20; Region: UPF0118; pfam01594
661410013011	Response regulator receiver domain; Region: Response_reg; pfam00072
661410013012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410013013	active site
661410013014	phosphorylation site [posttranslational modification]
661410013015	intermolecular recognition site; other site
661410013016	dimerization interface [polypeptide binding]; other site
661410013017	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
661410013018	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
661410013019	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
661410013020	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
661410013021	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
661410013022	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
661410013023	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410013024	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
661410013025	putative active site [active]
661410013026	heme pocket [chemical binding]; other site
661410013027	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410013028	putative active site [active]
661410013029	heme pocket [chemical binding]; other site
661410013030	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410013031	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410013032	dimer interface [polypeptide binding]; other site
661410013033	phosphorylation site [posttranslational modification]
661410013034	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410013035	ATP binding site [chemical binding]; other site
661410013036	Mg2+ binding site [ion binding]; other site
661410013037	G-X-G motif; other site
661410013038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410013039	active site
661410013040	phosphorylation site [posttranslational modification]
661410013041	intermolecular recognition site; other site
661410013042	dimerization interface [polypeptide binding]; other site
661410013043	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410013044	active site
661410013045	phosphorylation site [posttranslational modification]
661410013046	intermolecular recognition site; other site
661410013047	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
661410013048	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
661410013049	DNA-binding site [nucleotide binding]; DNA binding site
661410013050	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
661410013051	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410013052	homodimer interface [polypeptide binding]; other site
661410013053	catalytic residue [active]
661410013054	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
661410013055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410013056	active site
661410013057	phosphorylation site [posttranslational modification]
661410013058	intermolecular recognition site; other site
661410013059	dimerization interface [polypeptide binding]; other site
661410013060	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
661410013061	DNA binding residues [nucleotide binding]
661410013062	dimerization interface [polypeptide binding]; other site
661410013063	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
661410013064	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
661410013065	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
661410013066	L-lactate permease; Region: Lactate_perm; cl00701
661410013067	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
661410013068	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
661410013069	dimanganese center [ion binding]; other site
661410013070	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
661410013071	substrate binding pocket [chemical binding]; other site
661410013072	substrate-Mg2+ binding site; other site
661410013073	aspartate-rich region 2; other site
661410013074	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
661410013075	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
661410013076	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
661410013077	Protein export membrane protein; Region: SecD_SecF; pfam02355
661410013078	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
661410013079	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
661410013080	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
661410013081	Preprotein translocase subunit; Region: YajC; pfam02699
661410013082	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
661410013083	Protein of unknown function (DUF815); Region: DUF815; pfam05673
661410013084	Walker A motif; other site
661410013085	ATP binding site [chemical binding]; other site
661410013086	Walker B motif; other site
661410013087	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
661410013088	Peptidase family M23; Region: Peptidase_M23; pfam01551
661410013089	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
661410013090	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
661410013091	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410013092	S-adenosylmethionine binding site [chemical binding]; other site
661410013093	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
661410013094	seryl-tRNA synthetase; Provisional; Region: PRK05431
661410013095	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
661410013096	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
661410013097	dimer interface [polypeptide binding]; other site
661410013098	active site
661410013099	motif 1; other site
661410013100	motif 2; other site
661410013101	motif 3; other site
661410013102	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
661410013103	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
661410013104	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
661410013105	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
661410013106	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
661410013107	substrate binding site [chemical binding]; other site
661410013108	oxyanion hole (OAH) forming residues; other site
661410013109	trimer interface [polypeptide binding]; other site
661410013110	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
661410013111	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
661410013112	dimer interface [polypeptide binding]; other site
661410013113	allosteric magnesium binding site [ion binding]; other site
661410013114	active site
661410013115	aspartate-rich active site metal binding site; other site
661410013116	Schiff base residues; other site
661410013117	RDD family; Region: RDD; pfam06271
661410013118	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
661410013119	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
661410013120	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
661410013121	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
661410013122	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
661410013123	maltose O-acetyltransferase; Provisional; Region: PRK10092
661410013124	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
661410013125	active site
661410013126	substrate binding site [chemical binding]; other site
661410013127	trimer interface [polypeptide binding]; other site
661410013128	CoA binding site [chemical binding]; other site
661410013129	Predicted metalloprotease [General function prediction only]; Region: COG2321
661410013130	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
661410013131	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
661410013132	Fe-S cluster binding site [ion binding]; other site
661410013133	active site
661410013134	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
661410013135	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
661410013136	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
661410013137	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
661410013138	putative active site pocket [active]
661410013139	cleavage site
661410013140	Predicted permeases [General function prediction only]; Region: RarD; COG2962
661410013141	cystathionine beta-lyase; Provisional; Region: PRK05967
661410013142	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
661410013143	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
661410013144	catalytic residue [active]
661410013145	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
661410013146	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
661410013147	NAD binding site [chemical binding]; other site
661410013148	catalytic Zn binding site [ion binding]; other site
661410013149	structural Zn binding site [ion binding]; other site
661410013150	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
661410013151	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
661410013152	PAS fold; Region: PAS_4; pfam08448
661410013153	PAS domain; Region: PAS; smart00091
661410013154	PAS fold; Region: PAS_4; pfam08448
661410013155	PAS domain S-box; Region: sensory_box; TIGR00229
661410013156	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410013157	putative active site [active]
661410013158	heme pocket [chemical binding]; other site
661410013159	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
661410013160	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410013161	putative active site [active]
661410013162	heme pocket [chemical binding]; other site
661410013163	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
661410013164	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410013165	putative active site [active]
661410013166	heme pocket [chemical binding]; other site
661410013167	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410013168	dimer interface [polypeptide binding]; other site
661410013169	phosphorylation site [posttranslational modification]
661410013170	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410013171	ATP binding site [chemical binding]; other site
661410013172	Mg2+ binding site [ion binding]; other site
661410013173	G-X-G motif; other site
661410013174	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410013175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410013176	active site
661410013177	phosphorylation site [posttranslational modification]
661410013178	intermolecular recognition site; other site
661410013179	dimerization interface [polypeptide binding]; other site
661410013180	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
661410013181	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
661410013182	Probable Catalytic site; other site
661410013183	metal-binding site
661410013184	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
661410013185	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
661410013186	Probable Catalytic site; other site
661410013187	metal-binding site
661410013188	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
661410013189	Methyltransferase domain; Region: Methyltransf_18; pfam12847
661410013190	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
661410013191	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
661410013192	putative dimer interface [polypeptide binding]; other site
661410013193	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
661410013194	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410013195	ATP binding site [chemical binding]; other site
661410013196	Mg2+ binding site [ion binding]; other site
661410013197	G-X-G motif; other site
661410013198	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
661410013199	ATP binding site [chemical binding]; other site
661410013200	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
661410013201	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
661410013202	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
661410013203	active site
661410013204	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
661410013205	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
661410013206	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
661410013207	ABC transporter; Region: ABC_tran_2; pfam12848
661410013208	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
661410013209	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
661410013210	RibD C-terminal domain; Region: RibD_C; cl17279
661410013211	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
661410013212	OsmC-like protein; Region: OsmC; cl00767
661410013213	Domain of unknown function (DUF336); Region: DUF336; cl01249
661410013214	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
661410013215	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
661410013216	peptide binding site [polypeptide binding]; other site
661410013217	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
661410013218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410013219	dimer interface [polypeptide binding]; other site
661410013220	conserved gate region; other site
661410013221	putative PBP binding loops; other site
661410013222	ABC-ATPase subunit interface; other site
661410013223	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
661410013224	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410013225	ABC-ATPase subunit interface; other site
661410013226	benzoate transport; Region: 2A0115; TIGR00895
661410013227	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410013228	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410013229	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820
661410013230	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410013231	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410013232	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
661410013233	dimerization interface [polypeptide binding]; other site
661410013234	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
661410013235	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
661410013236	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
661410013237	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
661410013238	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
661410013239	DsbD alpha interface [polypeptide binding]; other site
661410013240	catalytic residues [active]
661410013241	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
661410013242	MutS domain I; Region: MutS_I; pfam01624
661410013243	MutS domain II; Region: MutS_II; pfam05188
661410013244	MutS domain III; Region: MutS_III; pfam05192
661410013245	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
661410013246	Walker A/P-loop; other site
661410013247	ATP binding site [chemical binding]; other site
661410013248	Q-loop/lid; other site
661410013249	ABC transporter signature motif; other site
661410013250	Walker B; other site
661410013251	D-loop; other site
661410013252	H-loop/switch region; other site
661410013253	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
661410013254	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
661410013255	ATP binding site [chemical binding]; other site
661410013256	putative Mg++ binding site [ion binding]; other site
661410013257	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
661410013258	nucleotide binding region [chemical binding]; other site
661410013259	ATP-binding site [chemical binding]; other site
661410013260	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
661410013261	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
661410013262	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
661410013263	active site
661410013264	dimer interface [polypeptide binding]; other site
661410013265	metal binding site [ion binding]; metal-binding site
661410013266	glutathione binding site [chemical binding]; other site
661410013267	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
661410013268	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
661410013269	active site
661410013270	DNA binding site [nucleotide binding]
661410013271	Int/Topo IB signature motif; other site
661410013272	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
661410013273	catalytic core [active]
661410013274	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
661410013275	Predicted ATPase [General function prediction only]; Region: COG4637
661410013276	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410013277	Walker A/P-loop; other site
661410013278	ATP binding site [chemical binding]; other site
661410013279	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
661410013280	MOSC domain; Region: MOSC; pfam03473
661410013281	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
661410013282	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
661410013283	NAD binding site [chemical binding]; other site
661410013284	homotetramer interface [polypeptide binding]; other site
661410013285	homodimer interface [polypeptide binding]; other site
661410013286	substrate binding site [chemical binding]; other site
661410013287	active site
661410013288	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
661410013289	HSP70 interaction site [polypeptide binding]; other site
661410013290	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
661410013291	substrate binding site [polypeptide binding]; other site
661410013292	dimer interface [polypeptide binding]; other site
661410013293	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
661410013294	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
661410013295	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
661410013296	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
661410013297	Response regulator receiver domain; Region: Response_reg; pfam00072
661410013298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410013299	active site
661410013300	phosphorylation site [posttranslational modification]
661410013301	intermolecular recognition site; other site
661410013302	dimerization interface [polypeptide binding]; other site
661410013303	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
661410013304	classical (c) SDRs; Region: SDR_c; cd05233
661410013305	NAD(P) binding site [chemical binding]; other site
661410013306	active site
661410013307	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
661410013308	nudix motif; other site
661410013309	Protein of unknown function (DUF2385); Region: DUF2385; pfam09539
661410013310	dihydroorotase; Validated; Region: PRK09060
661410013311	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
661410013312	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
661410013313	active site
661410013314	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
661410013315	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
661410013316	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
661410013317	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
661410013318	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
661410013319	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
661410013320	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
661410013321	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
661410013322	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
661410013323	TPP-binding site; other site
661410013324	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
661410013325	PYR/PP interface [polypeptide binding]; other site
661410013326	dimer interface [polypeptide binding]; other site
661410013327	TPP binding site [chemical binding]; other site
661410013328	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
661410013329	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
661410013330	E-class dimer interface [polypeptide binding]; other site
661410013331	P-class dimer interface [polypeptide binding]; other site
661410013332	active site
661410013333	Cu2+ binding site [ion binding]; other site
661410013334	Zn2+ binding site [ion binding]; other site
661410013335	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
661410013336	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
661410013337	RNA binding surface [nucleotide binding]; other site
661410013338	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410013339	S-adenosylmethionine binding site [chemical binding]; other site
661410013340	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
661410013341	Protein of unknown function (DUF563); Region: DUF563; pfam04577
661410013342	DHHW protein; Region: DHHW; pfam14286
661410013343	Uncharacterized conserved protein [Function unknown]; Region: COG2135
661410013344	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
661410013345	Protein of unknown function, DUF482; Region: DUF482; pfam04339
661410013346	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
661410013347	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
661410013348	metal binding site [ion binding]; metal-binding site
661410013349	putative dimer interface [polypeptide binding]; other site
661410013350	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
661410013351	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
661410013352	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
661410013353	DNA binding site [nucleotide binding]
661410013354	active site
661410013355	Cation efflux family; Region: Cation_efflux; pfam01545
661410013356	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
661410013357	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
661410013358	HIT family signature motif; other site
661410013359	catalytic residue [active]
661410013360	PilZ domain; Region: PilZ; pfam07238
661410013361	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
661410013362	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
661410013363	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
661410013364	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
661410013365	active site
661410013366	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
661410013367	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
661410013368	dimer interface [polypeptide binding]; other site
661410013369	active site
661410013370	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
661410013371	dimer interface [polypeptide binding]; other site
661410013372	active site
661410013373	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
661410013374	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
661410013375	putative active site [active]
661410013376	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
661410013377	putative catalytic site [active]
661410013378	putative metal binding site [ion binding]; other site
661410013379	putative phosphate binding site [ion binding]; other site
661410013380	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
661410013381	active site
661410013382	homotetramer interface [polypeptide binding]; other site
661410013383	homodimer interface [polypeptide binding]; other site
661410013384	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
661410013385	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
661410013386	putative active site [active]
661410013387	catalytic site [active]
661410013388	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
661410013389	putative active site [active]
661410013390	catalytic site [active]
661410013391	Uncharacterized conserved protein [Function unknown]; Region: COG0398
661410013392	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
661410013393	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
661410013394	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
661410013395	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
661410013396	Subunit I/III interface [polypeptide binding]; other site
661410013397	Subunit III/IV interface [polypeptide binding]; other site
661410013398	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
661410013399	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
661410013400	D-pathway; other site
661410013401	Putative ubiquinol binding site [chemical binding]; other site
661410013402	Low-spin heme (heme b) binding site [chemical binding]; other site
661410013403	Putative water exit pathway; other site
661410013404	Binuclear center (heme o3/CuB) [ion binding]; other site
661410013405	K-pathway; other site
661410013406	Putative proton exit pathway; other site
661410013407	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
661410013408	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
661410013409	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
661410013410	metabolite-proton symporter; Region: 2A0106; TIGR00883
661410013411	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410013412	putative substrate translocation pore; other site
661410013413	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
661410013414	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410013415	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410013416	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410013417	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410013418	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
661410013419	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
661410013420	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
661410013421	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410013422	active site
661410013423	phosphorylation site [posttranslational modification]
661410013424	intermolecular recognition site; other site
661410013425	dimerization interface [polypeptide binding]; other site
661410013426	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
661410013427	DNA binding residues [nucleotide binding]
661410013428	dimerization interface [polypeptide binding]; other site
661410013429	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
661410013430	Histidine kinase; Region: HisKA_3; pfam07730
661410013431	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410013432	ATP binding site [chemical binding]; other site
661410013433	Mg2+ binding site [ion binding]; other site
661410013434	G-X-G motif; other site
661410013435	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
661410013436	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
661410013437	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
661410013438	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
661410013439	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
661410013440	DNA binding residues [nucleotide binding]
661410013441	dimerization interface [polypeptide binding]; other site
661410013442	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
661410013443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410013444	active site
661410013445	phosphorylation site [posttranslational modification]
661410013446	intermolecular recognition site; other site
661410013447	dimerization interface [polypeptide binding]; other site
661410013448	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
661410013449	DNA binding residues [nucleotide binding]
661410013450	dimerization interface [polypeptide binding]; other site
661410013451	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
661410013452	active site
661410013453	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
661410013454	INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184
661410013455	Int/Topo IB signature motif; other site
661410013456	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
661410013457	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410013458	sequence-specific DNA binding site [nucleotide binding]; other site
661410013459	salt bridge; other site
661410013460	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
661410013461	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
661410013462	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
661410013463	Protein of unknown function DUF262; Region: DUF262; pfam03235
661410013464	Uncharacterized conserved protein [Function unknown]; Region: COG1479
661410013465	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
661410013466	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
661410013467	Part of AAA domain; Region: AAA_19; pfam13245
661410013468	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
661410013469	AAA domain; Region: AAA_12; pfam13087
661410013470	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
661410013471	putative active site [active]
661410013472	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
661410013473	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
661410013474	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
661410013475	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
661410013476	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410013477	AAA domain; Region: AAA_22; pfam13401
661410013478	Walker A motif; other site
661410013479	ATP binding site [chemical binding]; other site
661410013480	Walker B motif; other site
661410013481	Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545
661410013482	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
661410013483	TPR motif; other site
661410013484	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
661410013485	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
661410013486	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
661410013487	Virulence factor SrfB; Region: SrfB; pfam07520
661410013488	Putative bacterial virulence factor; Region: Virul_Fac; pfam10139
661410013489	TPR repeat; Region: TPR_11; pfam13414
661410013490	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
661410013491	binding surface
661410013492	TPR motif; other site
661410013493	TPR repeat; Region: TPR_11; pfam13414
661410013494	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
661410013495	binding surface
661410013496	TPR motif; other site
661410013497	TPR repeat; Region: TPR_11; pfam13414
661410013498	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
661410013499	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
661410013500	putative ligand binding site [chemical binding]; other site
661410013501	putative NAD binding site [chemical binding]; other site
661410013502	catalytic site [active]
661410013503	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410013504	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410013505	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
661410013506	putative dimerization interface [polypeptide binding]; other site
661410013507	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
661410013508	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
661410013509	putative ligand binding site [chemical binding]; other site
661410013510	NAD binding site [chemical binding]; other site
661410013511	catalytic site [active]
661410013512	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
661410013513	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
661410013514	substrate binding site [chemical binding]; other site
661410013515	ligand binding site [chemical binding]; other site
661410013516	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
661410013517	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
661410013518	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410013519	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410013520	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
661410013521	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
661410013522	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
661410013523	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
661410013524	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
661410013525	potential catalytic triad [active]
661410013526	conserved cys residue [active]
661410013527	Amidase; Region: Amidase; cl11426
661410013528	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049
661410013529	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410013530	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410013531	ligand binding site [chemical binding]; other site
661410013532	flexible hinge region; other site
661410013533	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
661410013534	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
661410013535	Cupin; Region: Cupin_6; pfam12852
661410013536	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
661410013537	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
661410013538	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
661410013539	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
661410013540	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
661410013541	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
661410013542	conserved cys residue [active]
661410013543	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
661410013544	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
661410013545	NMT1-like family; Region: NMT1_2; pfam13379
661410013546	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
661410013547	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410013548	dimer interface [polypeptide binding]; other site
661410013549	conserved gate region; other site
661410013550	putative PBP binding loops; other site
661410013551	ABC-ATPase subunit interface; other site
661410013552	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
661410013553	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
661410013554	Walker A/P-loop; other site
661410013555	ATP binding site [chemical binding]; other site
661410013556	Q-loop/lid; other site
661410013557	ABC transporter signature motif; other site
661410013558	Walker B; other site
661410013559	D-loop; other site
661410013560	H-loop/switch region; other site
661410013561	tellurite resistance protein terB; Region: terB; cd07176
661410013562	putative metal binding site [ion binding]; other site
661410013563	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
661410013564	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
661410013565	G1 box; other site
661410013566	putative GEF interaction site [polypeptide binding]; other site
661410013567	GTP/Mg2+ binding site [chemical binding]; other site
661410013568	Switch I region; other site
661410013569	G2 box; other site
661410013570	G3 box; other site
661410013571	Switch II region; other site
661410013572	G4 box; other site
661410013573	G5 box; other site
661410013574	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
661410013575	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
661410013576	classical (c) SDRs; Region: SDR_c; cd05233
661410013577	NAD(P) binding site [chemical binding]; other site
661410013578	active site
661410013579	elongation factor Tu; Reviewed; Region: PRK00049
661410013580	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
661410013581	G1 box; other site
661410013582	GEF interaction site [polypeptide binding]; other site
661410013583	GTP/Mg2+ binding site [chemical binding]; other site
661410013584	Switch I region; other site
661410013585	G2 box; other site
661410013586	G3 box; other site
661410013587	Switch II region; other site
661410013588	G4 box; other site
661410013589	G5 box; other site
661410013590	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
661410013591	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
661410013592	Antibiotic Binding Site [chemical binding]; other site
661410013593	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
661410013594	RNA binding surface [nucleotide binding]; other site
661410013595	DEAD/DEAH box helicase; Region: DEAD; pfam00270
661410013596	ATP binding site [chemical binding]; other site
661410013597	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
661410013598	putative Mg++ binding site [ion binding]; other site
661410013599	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
661410013600	nucleotide binding region [chemical binding]; other site
661410013601	ATP-binding site [chemical binding]; other site
661410013602	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
661410013603	Glucokinase; Region: Glucokinase; cl17310
661410013604	glucokinase, proteobacterial type; Region: glk; TIGR00749
661410013605	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
661410013606	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
661410013607	Domain of unknown function (DUF427); Region: DUF427; pfam04248
661410013608	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
661410013609	Beta-lactamase; Region: Beta-lactamase; pfam00144
661410013610	BCCT family transporter; Region: BCCT; pfam02028
661410013611	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
661410013612	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
661410013613	putative dimer interface [polypeptide binding]; other site
661410013614	[2Fe-2S] cluster binding site [ion binding]; other site
661410013615	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
661410013616	putative dimer interface [polypeptide binding]; other site
661410013617	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
661410013618	SLBB domain; Region: SLBB; pfam10531
661410013619	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
661410013620	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
661410013621	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
661410013622	catalytic loop [active]
661410013623	iron binding site [ion binding]; other site
661410013624	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
661410013625	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
661410013626	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
661410013627	[4Fe-4S] binding site [ion binding]; other site
661410013628	molybdopterin cofactor binding site; other site
661410013629	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
661410013630	molybdopterin cofactor binding site; other site
661410013631	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
661410013632	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410013633	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410013634	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
661410013635	dimerization interface [polypeptide binding]; other site
661410013636	GTPase CgtA; Reviewed; Region: obgE; PRK12299
661410013637	GTP1/OBG; Region: GTP1_OBG; pfam01018
661410013638	Obg GTPase; Region: Obg; cd01898
661410013639	G1 box; other site
661410013640	GTP/Mg2+ binding site [chemical binding]; other site
661410013641	Switch I region; other site
661410013642	G2 box; other site
661410013643	G3 box; other site
661410013644	Switch II region; other site
661410013645	G4 box; other site
661410013646	G5 box; other site
661410013647	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
661410013648	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
661410013649	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
661410013650	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
661410013651	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
661410013652	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
661410013653	Putative hemolysin [General function prediction only]; Region: COG3176
661410013654	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410013655	Major Facilitator Superfamily; Region: MFS_1; pfam07690
661410013656	putative substrate translocation pore; other site
661410013657	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
661410013658	nucleophile elbow; other site
661410013659	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
661410013660	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
661410013661	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
661410013662	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
661410013663	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
661410013664	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
661410013665	active site
661410013666	metal binding site [ion binding]; metal-binding site
661410013667	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
661410013668	Na binding site [ion binding]; other site
661410013669	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
661410013670	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
661410013671	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410013672	putative active site [active]
661410013673	heme pocket [chemical binding]; other site
661410013674	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410013675	dimer interface [polypeptide binding]; other site
661410013676	phosphorylation site [posttranslational modification]
661410013677	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410013678	ATP binding site [chemical binding]; other site
661410013679	Mg2+ binding site [ion binding]; other site
661410013680	G-X-G motif; other site
661410013681	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
661410013682	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410013683	active site
661410013684	phosphorylation site [posttranslational modification]
661410013685	intermolecular recognition site; other site
661410013686	dimerization interface [polypeptide binding]; other site
661410013687	tellurium resistance terB-like protein; Region: terB_like; cl11965
661410013688	metal binding site [ion binding]; metal-binding site
661410013689	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
661410013690	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
661410013691	Substrate binding site; other site
661410013692	metal-binding site
661410013693	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
661410013694	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
661410013695	Phosphotransferase enzyme family; Region: APH; pfam01636
661410013696	PAS fold; Region: PAS_7; pfam12860
661410013697	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
661410013698	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410013699	dimer interface [polypeptide binding]; other site
661410013700	phosphorylation site [posttranslational modification]
661410013701	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410013702	ATP binding site [chemical binding]; other site
661410013703	Mg2+ binding site [ion binding]; other site
661410013704	G-X-G motif; other site
661410013705	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
661410013706	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
661410013707	homotetramer interface [polypeptide binding]; other site
661410013708	ligand binding site [chemical binding]; other site
661410013709	catalytic site [active]
661410013710	NAD binding site [chemical binding]; other site
661410013711	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
661410013712	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
661410013713	acyl-activating enzyme (AAE) consensus motif; other site
661410013714	AMP binding site [chemical binding]; other site
661410013715	active site
661410013716	CoA binding site [chemical binding]; other site
661410013717	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
661410013718	putative FMN binding site [chemical binding]; other site
661410013719	enoyl-CoA hydratase; Validated; Region: PRK08139
661410013720	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
661410013721	substrate binding site [chemical binding]; other site
661410013722	oxyanion hole (OAH) forming residues; other site
661410013723	trimer interface [polypeptide binding]; other site
661410013724	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
661410013725	putative catalytic site [active]
661410013726	putative metal binding site [ion binding]; other site
661410013727	putative phosphate binding site [ion binding]; other site
661410013728	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
661410013729	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
661410013730	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
661410013731	putative active site [active]
661410013732	catalytic site [active]
661410013733	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
661410013734	putative active site [active]
661410013735	catalytic site [active]
661410013736	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
661410013737	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
661410013738	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
661410013739	Family description; Region: UvrD_C_2; pfam13538
661410013740	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
661410013741	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
661410013742	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
661410013743	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
661410013744	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
661410013745	catalytic residues [active]
661410013746	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
661410013747	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
661410013748	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
661410013749	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
661410013750	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
661410013751	substrate binding site [chemical binding]; other site
661410013752	active site
661410013753	catalytic residues [active]
661410013754	heterodimer interface [polypeptide binding]; other site
661410013755	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
661410013756	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
661410013757	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
661410013758	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
661410013759	putative NADH binding site [chemical binding]; other site
661410013760	putative active site [active]
661410013761	nudix motif; other site
661410013762	putative metal binding site [ion binding]; other site
661410013763	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
661410013764	nucleotide binding site/active site [active]
661410013765	HIT family signature motif; other site
661410013766	catalytic residue [active]
661410013767	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
661410013768	active site
661410013769	phosphorylation site [posttranslational modification]
661410013770	intermolecular recognition site; other site
661410013771	dimerization interface [polypeptide binding]; other site
661410013772	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
661410013773	Zn2+ binding site [ion binding]; other site
661410013774	Mg2+ binding site [ion binding]; other site
661410013775	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
661410013776	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
661410013777	ATP binding site [chemical binding]; other site
661410013778	putative Mg++ binding site [ion binding]; other site
661410013779	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
661410013780	nucleotide binding region [chemical binding]; other site
661410013781	ATP-binding site [chemical binding]; other site
661410013782	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
661410013783	RNA binding site [nucleotide binding]; other site
661410013784	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410013785	dimerization interface [polypeptide binding]; other site
661410013786	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
661410013787	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410013788	ATP binding site [chemical binding]; other site
661410013789	G-X-G motif; other site
661410013790	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
661410013791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410013792	active site
661410013793	phosphorylation site [posttranslational modification]
661410013794	intermolecular recognition site; other site
661410013795	dimerization interface [polypeptide binding]; other site
661410013796	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
661410013797	DNA binding residues [nucleotide binding]
661410013798	dimerization interface [polypeptide binding]; other site
661410013799	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
661410013800	amino acid transporter; Region: 2A0306; TIGR00909
661410013801	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
661410013802	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
661410013803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
661410013804	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410013805	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
661410013806	Walker A/P-loop; other site
661410013807	ATP binding site [chemical binding]; other site
661410013808	Q-loop/lid; other site
661410013809	ABC transporter signature motif; other site
661410013810	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
661410013811	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
661410013812	putative active site [active]
661410013813	putative dimer interface [polypeptide binding]; other site
661410013814	RNA polymerase sigma factor; Provisional; Region: PRK12547
661410013815	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
661410013816	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
661410013817	DNA binding residues [nucleotide binding]
661410013818	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
661410013819	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
661410013820	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
661410013821	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
661410013822	catalytic loop [active]
661410013823	iron binding site [ion binding]; other site
661410013824	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
661410013825	putative binding surface; other site
661410013826	active site
661410013827	electron transport complex protein RnfC; Provisional; Region: PRK05035
661410013828	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
661410013829	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410013830	non-specific DNA binding site [nucleotide binding]; other site
661410013831	salt bridge; other site
661410013832	sequence-specific DNA binding site [nucleotide binding]; other site
661410013833	Cupin domain; Region: Cupin_2; pfam07883
661410013834	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
661410013835	dimer interface [polypeptide binding]; other site
661410013836	substrate binding site [chemical binding]; other site
661410013837	ATP binding site [chemical binding]; other site
661410013838	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
661410013839	active site
661410013840	thiamine phosphate binding site [chemical binding]; other site
661410013841	pyrophosphate binding site [ion binding]; other site
661410013842	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
661410013843	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
661410013844	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
661410013845	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
661410013846	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
661410013847	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
661410013848	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
661410013849	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410013850	S-adenosylmethionine binding site [chemical binding]; other site
661410013851	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
661410013852	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
661410013853	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
661410013854	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
661410013855	active site
661410013856	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
661410013857	Low molecular weight phosphatase family; Region: LMWPc; cd00115
661410013858	active site
661410013859	Fructosamine kinase; Region: Fructosamin_kin; cl17579
661410013860	Phosphotransferase enzyme family; Region: APH; pfam01636
661410013861	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
661410013862	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
661410013863	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
661410013864	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
661410013865	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
661410013866	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
661410013867	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
661410013868	putative C-terminal domain interface [polypeptide binding]; other site
661410013869	putative GSH binding site (G-site) [chemical binding]; other site
661410013870	putative dimer interface [polypeptide binding]; other site
661410013871	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
661410013872	putative N-terminal domain interface [polypeptide binding]; other site
661410013873	putative dimer interface [polypeptide binding]; other site
661410013874	putative substrate binding pocket (H-site) [chemical binding]; other site
661410013875	transcriptional regulator; Provisional; Region: PRK10632
661410013876	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410013877	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
661410013878	putative effector binding pocket; other site
661410013879	putative dimerization interface [polypeptide binding]; other site
661410013880	sulfite reductase; Provisional; Region: PRK06214
661410013881	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
661410013882	FAD binding pocket [chemical binding]; other site
661410013883	FAD binding motif [chemical binding]; other site
661410013884	catalytic residues [active]
661410013885	NAD binding pocket [chemical binding]; other site
661410013886	phosphate binding motif [ion binding]; other site
661410013887	beta-alpha-beta structure motif; other site
661410013888	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567
661410013889	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
661410013890	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
661410013891	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
661410013892	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
661410013893	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
661410013894	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
661410013895	Walker A/P-loop; other site
661410013896	ATP binding site [chemical binding]; other site
661410013897	Q-loop/lid; other site
661410013898	ABC transporter signature motif; other site
661410013899	Walker B; other site
661410013900	D-loop; other site
661410013901	H-loop/switch region; other site
661410013902	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
661410013903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410013904	dimer interface [polypeptide binding]; other site
661410013905	conserved gate region; other site
661410013906	putative PBP binding loops; other site
661410013907	ABC-ATPase subunit interface; other site
661410013908	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
661410013909	NMT1-like family; Region: NMT1_2; pfam13379
661410013910	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
661410013911	NMT1-like family; Region: NMT1_2; pfam13379
661410013912	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
661410013913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
661410013914	active site
661410013915	phosphorylation site [posttranslational modification]
661410013916	intermolecular recognition site; other site
661410013917	ANTAR domain; Region: ANTAR; pfam03861
661410013918	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
661410013919	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
661410013920	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
661410013921	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
661410013922	TPP-binding site [chemical binding]; other site
661410013923	dimer interface [polypeptide binding]; other site
661410013924	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
661410013925	PYR/PP interface [polypeptide binding]; other site
661410013926	dimer interface [polypeptide binding]; other site
661410013927	TPP binding site [chemical binding]; other site
661410013928	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
661410013929	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
661410013930	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
661410013931	putative active site [active]
661410013932	catalytic residue [active]
661410013933	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
661410013934	active site
661410013935	dimer interface [polypeptide binding]; other site
661410013936	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
661410013937	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
661410013938	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
661410013939	PAS domain; Region: PAS_9; pfam13426
661410013940	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410013941	putative active site [active]
661410013942	heme pocket [chemical binding]; other site
661410013943	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
661410013944	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410013945	dimer interface [polypeptide binding]; other site
661410013946	putative CheW interface [polypeptide binding]; other site
661410013947	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
661410013948	short chain dehydrogenase; Provisional; Region: PRK07109
661410013949	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410013950	NAD(P) binding site [chemical binding]; other site
661410013951	active site
661410013952	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
661410013953	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410013954	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
661410013955	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410013956	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
661410013957	active site residue [active]
661410013958	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
661410013959	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410013960	Autoinducer synthetase; Region: Autoind_synth; cl17404
661410013961	Autoinducer binding domain; Region: Autoind_bind; pfam03472
661410013962	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
661410013963	DNA binding residues [nucleotide binding]
661410013964	dimerization interface [polypeptide binding]; other site
661410013965	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
661410013966	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
661410013967	Protein of unknown function (DUF563); Region: DUF563; pfam04577
661410013968	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
661410013969	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410013970	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410013971	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
661410013972	putative substrate binding pocket [chemical binding]; other site
661410013973	putative dimerization interface [polypeptide binding]; other site
661410013974	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
661410013975	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
661410013976	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
661410013977	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
661410013978	Trp docking motif [polypeptide binding]; other site
661410013979	active site
661410013980	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410013981	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
661410013982	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410013983	Histidine kinase; Region: HisKA_2; pfam07568
661410013984	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410013985	ATP binding site [chemical binding]; other site
661410013986	Mg2+ binding site [ion binding]; other site
661410013987	G-X-G motif; other site
661410013988	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
661410013989	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
661410013990	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
661410013991	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
661410013992	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
661410013993	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
661410013994	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
661410013995	catalytic loop [active]
661410013996	iron binding site [ion binding]; other site
661410013997	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
661410013998	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
661410013999	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
661410014000	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
661410014001	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410014002	NAD(P) binding site [chemical binding]; other site
661410014003	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
661410014004	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
661410014005	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
661410014006	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
661410014007	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
661410014008	Protein of unknown function, DUF606; Region: DUF606; pfam04657
661410014009	Transcriptional regulator [Transcription]; Region: LysR; COG0583
661410014010	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
661410014011	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
661410014012	dimerization interface [polypeptide binding]; other site
661410014013	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
661410014014	Enoylreductase; Region: PKS_ER; smart00829
661410014015	NAD(P) binding site [chemical binding]; other site
661410014016	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410014017	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
661410014018	PAS domain S-box; Region: sensory_box; TIGR00229
661410014019	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410014020	putative active site [active]
661410014021	heme pocket [chemical binding]; other site
661410014022	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
661410014023	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
661410014024	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410014025	PAS fold; Region: PAS_3; pfam08447
661410014026	putative active site [active]
661410014027	heme pocket [chemical binding]; other site
661410014028	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410014029	HWE histidine kinase; Region: HWE_HK; smart00911
661410014030	response regulator; Provisional; Region: PRK13435
661410014031	Bacterial SH3 domain; Region: SH3_3; pfam08239
661410014032	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410014033	NAD(P) binding site [chemical binding]; other site
661410014034	active site
661410014035	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
661410014036	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
661410014037	dimer interface [polypeptide binding]; other site
661410014038	active site
661410014039	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
661410014040	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
661410014041	active site
661410014042	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764
661410014043	active site 2 [active]
661410014044	active site 1 [active]
661410014045	acyl carrier protein; Provisional; Region: PRK06508
661410014046	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
661410014047	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004
661410014048	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
661410014049	Cupin domain; Region: Cupin_2; cl17218
661410014050	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
661410014051	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
661410014052	putative dimer interface [polypeptide binding]; other site
661410014053	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
661410014054	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
661410014055	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
661410014056	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
661410014057	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
661410014058	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
661410014059	active site
661410014060	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
661410014061	Domain of unknown function DUF20; Region: UPF0118; pfam01594
661410014062	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
661410014063	putative active site [active]
661410014064	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
661410014065	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
661410014066	active site
661410014067	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
661410014068	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
661410014069	Domain of unknown function DUF59; Region: DUF59; pfam01883
661410014070	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
661410014071	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
661410014072	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
661410014073	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
661410014074	GTP binding site; other site
661410014075	DNA gyrase subunit A; Validated; Region: PRK05560
661410014076	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
661410014077	CAP-like domain; other site
661410014078	active site
661410014079	primary dimer interface [polypeptide binding]; other site
661410014080	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
661410014081	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
661410014082	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
661410014083	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
661410014084	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
661410014085	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
661410014086	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
661410014087	active site
661410014088	(T/H)XGH motif; other site
661410014089	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
661410014090	active site
661410014091	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
661410014092	active site
661410014093	Response regulator receiver domain; Region: Response_reg; pfam00072
661410014094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410014095	active site
661410014096	phosphorylation site [posttranslational modification]
661410014097	intermolecular recognition site; other site
661410014098	dimerization interface [polypeptide binding]; other site
661410014099	Uncharacterized conserved protein [Function unknown]; Region: COG4544
661410014100	DNA Polymerase Y-family; Region: PolY_like; cd03468
661410014101	active site
661410014102	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
661410014103	DNA binding site [nucleotide binding]
661410014104	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
661410014105	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
661410014106	putative active site [active]
661410014107	putative PHP Thumb interface [polypeptide binding]; other site
661410014108	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
661410014109	generic binding surface II; other site
661410014110	generic binding surface I; other site
661410014111	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
661410014112	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
661410014113	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
661410014114	active site
661410014115	nucleophile elbow; other site
661410014116	Patatin phospholipase; Region: DUF3734; pfam12536
661410014117	Ion channel; Region: Ion_trans_2; pfam07885
661410014118	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
661410014119	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082
661410014120	putative dimer interface [polypeptide binding]; other site
661410014121	[2Fe-2S] cluster binding site [ion binding]; other site
661410014122	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
661410014123	SLBB domain; Region: SLBB; pfam10531
661410014124	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
661410014125	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
661410014126	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
661410014127	catalytic loop [active]
661410014128	iron binding site [ion binding]; other site
661410014129	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
661410014130	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
661410014131	[4Fe-4S] binding site [ion binding]; other site
661410014132	molybdopterin cofactor binding site; other site
661410014133	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
661410014134	molybdopterin cofactor binding site; other site
661410014135	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
661410014136	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
661410014137	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
661410014138	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
661410014139	putative active site [active]
661410014140	putative metal binding site [ion binding]; other site
661410014141	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410014142	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
661410014143	Right handed beta helix region; Region: Beta_helix; pfam13229
661410014144	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
661410014145	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
661410014146	classical (c) SDRs; Region: SDR_c; cd05233
661410014147	NAD(P) binding site [chemical binding]; other site
661410014148	active site
661410014149	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
661410014150	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
661410014151	AMP binding site [chemical binding]; other site
661410014152	active site
661410014153	acyl-activating enzyme (AAE) consensus motif; other site
661410014154	CoA binding site [chemical binding]; other site
661410014155	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
661410014156	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
661410014157	Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670
661410014158	dimer interface [polypeptide binding]; other site
661410014159	active site
661410014160	motif 2; other site
661410014161	motif 3; other site
661410014162	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
661410014163	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
661410014164	active site
661410014165	acyl carrier protein; Provisional; Region: PRK07081
661410014166	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
661410014167	thiamine pyrophosphate protein; Validated; Region: PRK08199
661410014168	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
661410014169	PYR/PP interface [polypeptide binding]; other site
661410014170	dimer interface [polypeptide binding]; other site
661410014171	TPP binding site [chemical binding]; other site
661410014172	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
661410014173	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
661410014174	TPP-binding site [chemical binding]; other site
661410014175	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
661410014176	aminotransferase; Provisional; Region: PRK13356
661410014177	homodimer interface [polypeptide binding]; other site
661410014178	substrate-cofactor binding pocket; other site
661410014179	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410014180	catalytic residue [active]
661410014181	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
661410014182	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
661410014183	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
661410014184	homodimer interface [polypeptide binding]; other site
661410014185	substrate-cofactor binding pocket; other site
661410014186	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410014187	catalytic residue [active]
661410014188	homoserine O-succinyltransferase; Provisional; Region: PRK05368
661410014189	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
661410014190	conserved cys residue [active]
661410014191	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
661410014192	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
661410014193	acyl-activating enzyme (AAE) consensus motif; other site
661410014194	AMP binding site [chemical binding]; other site
661410014195	active site
661410014196	CoA binding site [chemical binding]; other site
661410014197	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
661410014198	Pectate lyase; Region: Pec_lyase_C; cl01593
661410014199	Right handed beta helix region; Region: Beta_helix; pfam13229
661410014200	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
661410014201	hypothetical protein; Provisional; Region: PRK01254
661410014202	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
661410014203	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
661410014204	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
661410014205	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
661410014206	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
661410014207	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
661410014208	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
661410014209	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
661410014210	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
661410014211	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
661410014212	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
661410014213	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
661410014214	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
661410014215	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
661410014216	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
661410014217	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
661410014218	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410014219	NAD(P) binding site [chemical binding]; other site
661410014220	active site
661410014221	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
661410014222	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
661410014223	NADP binding site [chemical binding]; other site
661410014224	active site
661410014225	putative substrate binding site [chemical binding]; other site
661410014226	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
661410014227	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
661410014228	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
661410014229	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
661410014230	Condensation domain; Region: Condensation; pfam00668
661410014231	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
661410014232	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
661410014233	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
661410014234	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
661410014235	Condensation domain; Region: Condensation; pfam00668
661410014236	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
661410014237	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
661410014238	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
661410014239	acyl-activating enzyme (AAE) consensus motif; other site
661410014240	AMP binding site [chemical binding]; other site
661410014241	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
661410014242	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
661410014243	catalytic core [active]
661410014244	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
661410014245	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
661410014246	active site
661410014247	catalytic tetrad [active]
661410014248	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
661410014249	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410014250	Walker A motif; other site
661410014251	ATP binding site [chemical binding]; other site
661410014252	Walker B motif; other site
661410014253	arginine finger; other site
661410014254	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
661410014255	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
661410014256	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
661410014257	TrkA-N domain; Region: TrkA_N; pfam02254
661410014258	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
661410014259	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
661410014260	NAD binding site [chemical binding]; other site
661410014261	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
661410014262	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
661410014263	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
661410014264	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
661410014265	Mg++ binding site [ion binding]; other site
661410014266	putative catalytic motif [active]
661410014267	putative substrate binding site [chemical binding]; other site
661410014268	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
661410014269	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
661410014270	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
661410014271	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
661410014272	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
661410014273	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
661410014274	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
661410014275	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
661410014276	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
661410014277	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
661410014278	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
661410014279	MraW methylase family; Region: Methyltransf_5; cl17771
661410014280	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
661410014281	Ligase N family; Region: LIGANc; smart00532
661410014282	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
661410014283	nucleotide binding pocket [chemical binding]; other site
661410014284	K-X-D-G motif; other site
661410014285	catalytic site [active]
661410014286	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
661410014287	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
661410014288	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
661410014289	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
661410014290	Dimer interface [polypeptide binding]; other site
661410014291	BRCT sequence motif; other site
661410014292	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
661410014293	putative active site [active]
661410014294	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
661410014295	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
661410014296	substrate binding site [chemical binding]; other site
661410014297	ATP binding site [chemical binding]; other site
661410014298	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
661410014299	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
661410014300	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
661410014301	CoA-transferase family III; Region: CoA_transf_3; pfam02515
661410014302	enoyl-CoA hydratase; Provisional; Region: PRK06144
661410014303	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
661410014304	substrate binding site [chemical binding]; other site
661410014305	oxyanion hole (OAH) forming residues; other site
661410014306	trimer interface [polypeptide binding]; other site
661410014307	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
661410014308	Transcriptional regulators [Transcription]; Region: GntR; COG1802
661410014309	DNA-binding site [nucleotide binding]; DNA binding site
661410014310	FCD domain; Region: FCD; pfam07729
661410014311	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
661410014312	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
661410014313	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
661410014314	catalytic residue [active]
661410014315	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
661410014316	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
661410014317	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
661410014318	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
661410014319	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
661410014320	DNA polymerase III subunit chi; Validated; Region: PRK05728
661410014321	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
661410014322	Protein of unknown function (DUF1190); Region: DUF1190; pfam06693
661410014323	Predicted membrane protein [Function unknown]; Region: COG3766
661410014324	CTP synthetase; Validated; Region: pyrG; PRK05380
661410014325	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
661410014326	Catalytic site [active]
661410014327	active site
661410014328	UTP binding site [chemical binding]; other site
661410014329	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
661410014330	active site
661410014331	putative oxyanion hole; other site
661410014332	catalytic triad [active]
661410014333	catalytic triad [active]
661410014334	Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335
661410014335	conserved cis-peptide bond; other site
661410014336	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
661410014337	triosephosphate isomerase; Provisional; Region: PRK14565
661410014338	substrate binding site [chemical binding]; other site
661410014339	dimer interface [polypeptide binding]; other site
661410014340	catalytic triad [active]
661410014341	periplasmic folding chaperone; Provisional; Region: PRK10788
661410014342	SurA N-terminal domain; Region: SurA_N_3; cl07813
661410014343	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
661410014344	anthranilate synthase component I; Provisional; Region: PRK13573
661410014345	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
661410014346	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
661410014347	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
661410014348	dimerization interface [polypeptide binding]; other site
661410014349	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410014350	dimer interface [polypeptide binding]; other site
661410014351	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
661410014352	putative CheW interface [polypeptide binding]; other site
661410014353	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
661410014354	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
661410014355	glutamine binding [chemical binding]; other site
661410014356	catalytic triad [active]
661410014357	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
661410014358	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
661410014359	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
661410014360	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
661410014361	active site
661410014362	ribulose/triose binding site [chemical binding]; other site
661410014363	phosphate binding site [ion binding]; other site
661410014364	substrate (anthranilate) binding pocket [chemical binding]; other site
661410014365	product (indole) binding pocket [chemical binding]; other site
661410014366	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
661410014367	trimer interface [polypeptide binding]; other site
661410014368	dimer interface [polypeptide binding]; other site
661410014369	putative active site [active]
661410014370	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
661410014371	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
661410014372	dimer interface [polypeptide binding]; other site
661410014373	putative functional site; other site
661410014374	putative MPT binding site; other site
661410014375	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
661410014376	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410014377	salt bridge; other site
661410014378	non-specific DNA binding site [nucleotide binding]; other site
661410014379	sequence-specific DNA binding site [nucleotide binding]; other site
661410014380	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
661410014381	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
661410014382	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
661410014383	active site
661410014384	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
661410014385	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
661410014386	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
661410014387	hypothetical protein; Validated; Region: PRK00124
661410014388	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
661410014389	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
661410014390	dimer interface [polypeptide binding]; other site
661410014391	active site
661410014392	citrylCoA binding site [chemical binding]; other site
661410014393	NADH binding [chemical binding]; other site
661410014394	cationic pore residues; other site
661410014395	oxalacetate/citrate binding site [chemical binding]; other site
661410014396	coenzyme A binding site [chemical binding]; other site
661410014397	catalytic triad [active]
661410014398	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
661410014399	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
661410014400	active site
661410014401	HIGH motif; other site
661410014402	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
661410014403	active site
661410014404	KMSKS motif; other site
661410014405	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
661410014406	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
661410014407	Competence protein; Region: Competence; pfam03772
661410014408	LexA repressor; Validated; Region: PRK00215
661410014409	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
661410014410	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
661410014411	Catalytic site [active]
661410014412	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
661410014413	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410014414	putative substrate translocation pore; other site
661410014415	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
661410014416	tartrate dehydrogenase; Region: TTC; TIGR02089
661410014417	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
661410014418	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
661410014419	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
661410014420	active site
661410014421	catalytic tetrad [active]
661410014422	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
661410014423	dimerization interface [polypeptide binding]; other site
661410014424	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410014425	dimer interface [polypeptide binding]; other site
661410014426	putative CheW interface [polypeptide binding]; other site
661410014427	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
661410014428	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
661410014429	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
661410014430	protein binding site [polypeptide binding]; other site
661410014431	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
661410014432	protein binding site [polypeptide binding]; other site
661410014433	Protein of unknown function (DUF2459); Region: DUF2459; pfam09601
661410014434	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
661410014435	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
661410014436	active site
661410014437	HIGH motif; other site
661410014438	nucleotide binding site [chemical binding]; other site
661410014439	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
661410014440	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
661410014441	active site
661410014442	KMSKS motif; other site
661410014443	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
661410014444	tRNA binding surface [nucleotide binding]; other site
661410014445	anticodon binding site; other site
661410014446	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
661410014447	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
661410014448	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
661410014449	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
661410014450	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410014451	S-adenosylmethionine binding site [chemical binding]; other site
661410014452	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
661410014453	putative substrate binding site [chemical binding]; other site
661410014454	putative ATP binding site [chemical binding]; other site
661410014455	PBP superfamily domain; Region: PBP_like_2; cl17296
661410014456	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
661410014457	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410014458	dimer interface [polypeptide binding]; other site
661410014459	conserved gate region; other site
661410014460	putative PBP binding loops; other site
661410014461	ABC-ATPase subunit interface; other site
661410014462	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
661410014463	dimer interface [polypeptide binding]; other site
661410014464	conserved gate region; other site
661410014465	putative PBP binding loops; other site
661410014466	ABC-ATPase subunit interface; other site
661410014467	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
661410014468	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
661410014469	Walker A/P-loop; other site
661410014470	ATP binding site [chemical binding]; other site
661410014471	Q-loop/lid; other site
661410014472	ABC transporter signature motif; other site
661410014473	Walker B; other site
661410014474	D-loop; other site
661410014475	H-loop/switch region; other site
661410014476	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
661410014477	PhoU domain; Region: PhoU; pfam01895
661410014478	PhoU domain; Region: PhoU; pfam01895
661410014479	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
661410014480	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410014481	active site
661410014482	phosphorylation site [posttranslational modification]
661410014483	intermolecular recognition site; other site
661410014484	dimerization interface [polypeptide binding]; other site
661410014485	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
661410014486	DNA binding site [nucleotide binding]
661410014487	GcrA cell cycle regulator; Region: GcrA; cl11564
661410014488	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
661410014489	DNA polymerase IV; Provisional; Region: PRK02794
661410014490	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
661410014491	active site
661410014492	DNA binding site [nucleotide binding]
661410014493	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
661410014494	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
661410014495	cobyric acid synthase; Provisional; Region: PRK00784
661410014496	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
661410014497	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
661410014498	catalytic triad [active]
661410014499	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
661410014500	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
661410014501	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
661410014502	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
661410014503	catalytic residue [active]
661410014504	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
661410014505	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
661410014506	CsbD-like; Region: CsbD; pfam05532
661410014507	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
661410014508	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
661410014509	NAD(P) binding site [chemical binding]; other site
661410014510	active site
661410014511	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
661410014512	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
661410014513	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
661410014514	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
661410014515	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
661410014516	HEPN domain; Region: HEPN; cl00824
661410014517	Transglycosylase SLT domain; Region: SLT_2; pfam13406
661410014518	murein hydrolase B; Provisional; Region: PRK10760; cl17906
661410014519	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
661410014520	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
661410014521	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
661410014522	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
661410014523	RNA binding surface [nucleotide binding]; other site
661410014524	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
661410014525	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
661410014526	FMN binding site [chemical binding]; other site
661410014527	substrate binding site [chemical binding]; other site
661410014528	putative catalytic residue [active]
661410014529	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
661410014530	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
661410014531	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
661410014532	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
661410014533	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
661410014534	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
661410014535	Walker A/P-loop; other site
661410014536	ATP binding site [chemical binding]; other site
661410014537	Q-loop/lid; other site
661410014538	ABC transporter signature motif; other site
661410014539	Walker B; other site
661410014540	D-loop; other site
661410014541	H-loop/switch region; other site
661410014542	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
661410014543	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
661410014544	Methyltransferase domain; Region: Methyltransf_24; pfam13578
661410014545	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
661410014546	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
661410014547	active site
661410014548	HIGH motif; other site
661410014549	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
661410014550	KMSKS motif; other site
661410014551	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
661410014552	tRNA binding surface [nucleotide binding]; other site
661410014553	anticodon binding site; other site
661410014554	CreA protein; Region: CreA; pfam05981
661410014555	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
661410014556	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
661410014557	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
661410014558	ligand binding site [chemical binding]; other site
661410014559	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410014560	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
661410014561	putative substrate translocation pore; other site
661410014562	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
661410014563	dimer interface [polypeptide binding]; other site
661410014564	Methyltransferase domain; Region: Methyltransf_31; pfam13847
661410014565	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410014566	S-adenosylmethionine binding site [chemical binding]; other site
661410014567	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
661410014568	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
661410014569	active site
661410014570	HIGH motif; other site
661410014571	nucleotide binding site [chemical binding]; other site
661410014572	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
661410014573	active site
661410014574	KMSKS motif; other site
661410014575	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
661410014576	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
661410014577	HlyD family secretion protein; Region: HlyD_3; pfam13437
661410014578	Fusaric acid resistance protein family; Region: FUSC; pfam04632
661410014579	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
661410014580	Domain of unknown function (DUF4345); Region: DUF4345; pfam14248
661410014581	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
661410014582	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
661410014583	C-terminal domain interface [polypeptide binding]; other site
661410014584	GSH binding site (G-site) [chemical binding]; other site
661410014585	dimer interface [polypeptide binding]; other site
661410014586	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
661410014587	N-terminal domain interface [polypeptide binding]; other site
661410014588	putative dimer interface [polypeptide binding]; other site
661410014589	active site
661410014590	translocation protein TolB; Provisional; Region: tolB; PRK05137
661410014591	TolB amino-terminal domain; Region: TolB_N; pfam04052
661410014592	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
661410014593	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
661410014594	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
661410014595	TolA protein; Region: tolA_full; TIGR02794
661410014596	TolR protein; Region: tolR; TIGR02801
661410014597	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
661410014598	TolQ protein; Region: tolQ; TIGR02796
661410014599	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
661410014600	dimer interface [polypeptide binding]; other site
661410014601	putative CheW interface [polypeptide binding]; other site
661410014602	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
661410014603	active site
661410014604	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
661410014605	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
661410014606	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
661410014607	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410014608	Walker A motif; other site
661410014609	ATP binding site [chemical binding]; other site
661410014610	Walker B motif; other site
661410014611	arginine finger; other site
661410014612	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
661410014613	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
661410014614	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
661410014615	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
661410014616	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
661410014617	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
661410014618	dimerization interface [polypeptide binding]; other site
661410014619	DPS ferroxidase diiron center [ion binding]; other site
661410014620	ion pore; other site
661410014621	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
661410014622	CoA binding domain; Region: CoA_binding_2; pfam13380
661410014623	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
661410014624	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
661410014625	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
661410014626	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
661410014627	Coenzyme A binding pocket [chemical binding]; other site
661410014628	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
661410014629	intersubunit interface [polypeptide binding]; other site
661410014630	active site
661410014631	Zn2+ binding site [ion binding]; other site
661410014632	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
661410014633	Restriction endonuclease; Region: Mrr_cat; pfam04471
661410014634	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
661410014635	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
661410014636	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
661410014637	Transglycosylase; Region: Transgly; pfam00912
661410014638	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
661410014639	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
661410014640	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
661410014641	cyclase homology domain; Region: CHD; cd07302
661410014642	nucleotidyl binding site; other site
661410014643	metal binding site [ion binding]; metal-binding site
661410014644	dimer interface [polypeptide binding]; other site
661410014645	MAPEG family; Region: MAPEG; cl09190
661410014646	AAA domain; Region: AAA_31; pfam13614
661410014647	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
661410014648	P-loop; other site
661410014649	Magnesium ion binding site [ion binding]; other site
661410014650	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
661410014651	Magnesium ion binding site [ion binding]; other site
661410014652	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
661410014653	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
661410014654	ring oligomerisation interface [polypeptide binding]; other site
661410014655	ATP/Mg binding site [chemical binding]; other site
661410014656	stacking interactions; other site
661410014657	hinge regions; other site
661410014658	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
661410014659	oligomerisation interface [polypeptide binding]; other site
661410014660	mobile loop; other site
661410014661	roof hairpin; other site
661410014662	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
661410014663	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
661410014664	Cl binding site [ion binding]; other site
661410014665	oligomer interface [polypeptide binding]; other site
661410014666	MarC family integral membrane protein; Region: MarC; cl00919
661410014667	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
661410014668	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
661410014669	FAD binding domain; Region: FAD_binding_4; pfam01565
661410014670	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
661410014671	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
661410014672	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
661410014673	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
661410014674	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
661410014675	Substrate binding site; other site
661410014676	Cupin domain; Region: Cupin_2; cl17218
661410014677	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
661410014678	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
661410014679	active site
661410014680	substrate binding site [chemical binding]; other site
661410014681	coenzyme B12 binding site [chemical binding]; other site
661410014682	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
661410014683	B12 binding site [chemical binding]; other site
661410014684	cobalt ligand [ion binding]; other site
661410014685	Protein of unknown function (DUF817); Region: DUF817; pfam05675
661410014686	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
661410014687	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
661410014688	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
661410014689	protein binding site [polypeptide binding]; other site
661410014690	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
661410014691	HSP70 interaction site [polypeptide binding]; other site
661410014692	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
661410014693	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
661410014694	Sporulation related domain; Region: SPOR; pfam05036
661410014695	Uncharacterized conserved protein [Function unknown]; Region: COG2127
661410014696	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
661410014697	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410014698	Walker A motif; other site
661410014699	ATP binding site [chemical binding]; other site
661410014700	Walker B motif; other site
661410014701	arginine finger; other site
661410014702	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410014703	Walker A motif; other site
661410014704	ATP binding site [chemical binding]; other site
661410014705	Walker B motif; other site
661410014706	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
661410014707	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
661410014708	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
661410014709	substrate-cofactor binding pocket; other site
661410014710	pyridoxal 5'-phosphate binding site [chemical binding]; other site
661410014711	catalytic residue [active]
661410014712	Protein of unknown function (DUF3623); Region: DUF3623; cl11843
661410014713	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
661410014714	diiron binding motif [ion binding]; other site
661410014715	putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054
661410014716	Bacterial PH domain; Region: DUF304; pfam03703
661410014717	photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150
661410014718	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581
661410014719	subunit C interaction residues; other site
661410014720	subunit M interaction residues [polypeptide binding]; other site
661410014721	subunit L interaction residues [polypeptide binding]; other site
661410014722	putative proton transfer pathway, P1; other site
661410014723	putative proton transfer pathway, P2; other site
661410014724	PUCC protein; Region: PUCC; pfam03209
661410014725	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
661410014726	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
661410014727	S-adenosylmethionine binding site [chemical binding]; other site
661410014728	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
661410014729	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
661410014730	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
661410014731	P-loop; other site
661410014732	magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405
661410014733	Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
661410014734	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
661410014735	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
661410014736	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
661410014737	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
661410014738	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
661410014739	light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842
661410014740	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
661410014741	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
661410014742	B12 binding domain; Region: B12-binding; pfam02310
661410014743	B12 binding site [chemical binding]; other site
661410014744	transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040
661410014745	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410014746	putative active site [active]
661410014747	heme pocket [chemical binding]; other site
661410014748	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
661410014749	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
661410014750	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
661410014751	UbiA prenyltransferase family; Region: UbiA; pfam01040
661410014752	PUCC protein; Region: PUCC; pfam03209
661410014753	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
661410014754	TspO/MBR family; Region: TspO_MBR; pfam03073
661410014755	Cytochrome c; Region: Cytochrom_C; pfam00034
661410014756	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
661410014757	Cytochrome c; Region: Cytochrom_C; pfam00034
661410014758	Cytochrome c; Region: Cytochrom_C; pfam00034
661410014759	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
661410014760	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
661410014761	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
661410014762	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
661410014763	putative active site [active]
661410014764	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
661410014765	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
661410014766	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
661410014767	Walker A/P-loop; other site
661410014768	ATP binding site [chemical binding]; other site
661410014769	Q-loop/lid; other site
661410014770	ABC transporter signature motif; other site
661410014771	Walker B; other site
661410014772	D-loop; other site
661410014773	H-loop/switch region; other site
661410014774	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
661410014775	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
661410014776	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
661410014777	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
661410014778	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
661410014779	ligand binding site [chemical binding]; other site
661410014780	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
661410014781	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
661410014782	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
661410014783	Mechanosensitive ion channel; Region: MS_channel; pfam00924
661410014784	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
661410014785	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
661410014786	active site
661410014787	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
661410014788	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
661410014789	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
661410014790	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
661410014791	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
661410014792	active site
661410014793	substrate binding site [chemical binding]; other site
661410014794	metal binding site [ion binding]; metal-binding site
661410014795	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
661410014796	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
661410014797	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
661410014798	Walker A motif; other site
661410014799	ATP binding site [chemical binding]; other site
661410014800	Walker B motif; other site
661410014801	arginine finger; other site
661410014802	Peptidase family M41; Region: Peptidase_M41; pfam01434
661410014803	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
661410014804	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
661410014805	Ligand Binding Site [chemical binding]; other site
661410014806	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
661410014807	Tetratricopeptide repeat; Region: TPR_6; pfam13174
661410014808	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
661410014809	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
661410014810	ligand binding site [chemical binding]; other site
661410014811	Response regulator receiver domain; Region: Response_reg; pfam00072
661410014812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410014813	active site
661410014814	phosphorylation site [posttranslational modification]
661410014815	intermolecular recognition site; other site
661410014816	dimerization interface [polypeptide binding]; other site
661410014817	GSCFA family; Region: GSCFA; pfam08885
661410014818	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
661410014819	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
661410014820	active site
661410014821	domain interfaces; other site
661410014822	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
661410014823	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
661410014824	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979
661410014825	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
661410014826	putative active site [active]
661410014827	putative catalytic site [active]
661410014828	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
661410014829	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
661410014830	TM-ABC transporter signature motif; other site
661410014831	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
661410014832	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
661410014833	Walker A/P-loop; other site
661410014834	ATP binding site [chemical binding]; other site
661410014835	Q-loop/lid; other site
661410014836	ABC transporter signature motif; other site
661410014837	Walker B; other site
661410014838	D-loop; other site
661410014839	H-loop/switch region; other site
661410014840	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
661410014841	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
661410014842	Walker A/P-loop; other site
661410014843	ATP binding site [chemical binding]; other site
661410014844	Q-loop/lid; other site
661410014845	ABC transporter signature motif; other site
661410014846	Walker B; other site
661410014847	D-loop; other site
661410014848	H-loop/switch region; other site
661410014849	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
661410014850	TM-ABC transporter signature motif; other site
661410014851	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
661410014852	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
661410014853	putative ligand binding site [chemical binding]; other site
661410014854	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
661410014855	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
661410014856	Transcriptional regulators [Transcription]; Region: GntR; COG1802
661410014857	DNA-binding site [nucleotide binding]; DNA binding site
661410014858	FCD domain; Region: FCD; pfam07729
661410014859	PAS fold; Region: PAS_3; pfam08447
661410014860	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
661410014861	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
661410014862	non-specific DNA binding site [nucleotide binding]; other site
661410014863	salt bridge; other site
661410014864	sequence-specific DNA binding site [nucleotide binding]; other site
661410014865	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
661410014866	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
661410014867	putative substrate translocation pore; other site
661410014868	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
661410014869	dimerization interface [polypeptide binding]; other site
661410014870	metal binding site [ion binding]; metal-binding site
661410014871	hypothetical protein; Validated; Region: PRK00029
661410014872	Uncharacterized conserved protein [Function unknown]; Region: COG0397
661410014873	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
661410014874	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
661410014875	PYR/PP interface [polypeptide binding]; other site
661410014876	dimer interface [polypeptide binding]; other site
661410014877	TPP binding site [chemical binding]; other site
661410014878	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
661410014879	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
661410014880	TPP-binding site [chemical binding]; other site
661410014881	dimer interface [polypeptide binding]; other site
661410014882	Methyltransferase domain; Region: Methyltransf_23; pfam13489
661410014883	Methyltransferase domain; Region: Methyltransf_12; pfam08242
661410014884	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
661410014885	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
661410014886	putative valine binding site [chemical binding]; other site
661410014887	dimer interface [polypeptide binding]; other site
661410014888	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
661410014889	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
661410014890	glutathionine S-transferase; Provisional; Region: PRK10542
661410014891	C-terminal domain interface [polypeptide binding]; other site
661410014892	GSH binding site (G-site) [chemical binding]; other site
661410014893	dimer interface [polypeptide binding]; other site
661410014894	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
661410014895	dimer interface [polypeptide binding]; other site
661410014896	substrate binding pocket (H-site) [chemical binding]; other site
661410014897	N-terminal domain interface [polypeptide binding]; other site
661410014898	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
661410014899	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
661410014900	active site
661410014901	dimer interface [polypeptide binding]; other site
661410014902	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
661410014903	Ligand Binding Site [chemical binding]; other site
661410014904	Molecular Tunnel; other site
661410014905	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
661410014906	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
661410014907	putative active site [active]
661410014908	putative dimer interface [polypeptide binding]; other site
661410014909	RNA polymerase sigma factor; Provisional; Region: PRK12546
661410014910	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
661410014911	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
661410014912	DNA binding residues [nucleotide binding]
661410014913	Response regulator receiver domain; Region: Response_reg; pfam00072
661410014914	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410014915	active site
661410014916	phosphorylation site [posttranslational modification]
661410014917	intermolecular recognition site; other site
661410014918	dimerization interface [polypeptide binding]; other site
661410014919	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
661410014920	Histidine kinase; Region: HisKA_2; pfam07568
661410014921	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410014922	ATP binding site [chemical binding]; other site
661410014923	Mg2+ binding site [ion binding]; other site
661410014924	G-X-G motif; other site
661410014925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410014926	Response regulator receiver domain; Region: Response_reg; pfam00072
661410014927	active site
661410014928	phosphorylation site [posttranslational modification]
661410014929	intermolecular recognition site; other site
661410014930	dimerization interface [polypeptide binding]; other site
661410014931	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
661410014932	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
661410014933	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
661410014934	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410014935	putative active site [active]
661410014936	PAS fold; Region: PAS_3; pfam08447
661410014937	heme pocket [chemical binding]; other site
661410014938	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
661410014939	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
661410014940	dimer interface [polypeptide binding]; other site
661410014941	phosphorylation site [posttranslational modification]
661410014942	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
661410014943	ATP binding site [chemical binding]; other site
661410014944	Mg2+ binding site [ion binding]; other site
661410014945	G-X-G motif; other site
661410014946	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
661410014947	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
661410014948	ligand binding site [chemical binding]; other site
661410014949	flexible hinge region; other site
661410014950	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
661410014951	putative switch regulator; other site
661410014952	non-specific DNA interactions [nucleotide binding]; other site
661410014953	DNA binding site [nucleotide binding]
661410014954	sequence specific DNA binding site [nucleotide binding]; other site
661410014955	putative cAMP binding site [chemical binding]; other site
661410014956	GAF domain; Region: GAF; pfam01590
661410014957	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
661410014958	PAS fold; Region: PAS_3; pfam08447
661410014959	putative active site [active]
661410014960	heme pocket [chemical binding]; other site
661410014961	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
661410014962	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
661410014963	active site
661410014964	phosphorylation site [posttranslational modification]
661410014965	intermolecular recognition site; other site
661410014966	dimerization interface [polypeptide binding]; other site
661410014967	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
661410014968	DNA binding residues [nucleotide binding]
661410014969	dimerization interface [polypeptide binding]; other site
661410014970	PAS domain; Region: PAS_9; pfam13426
661410014971	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
661410014972	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
661410014973	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
661410014974	propionate/acetate kinase; Provisional; Region: PRK12379
661410014975	Acetokinase family; Region: Acetate_kinase; cl17229
661410014976	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
661410014977	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
661410014978	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
661410014979	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
661410014980	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
661410014981	Phosphotransferase enzyme family; Region: APH; pfam01636
661410014982	active site
661410014983	ATP binding site [chemical binding]; other site
661410014984	substrate binding site [chemical binding]; other site
661410014985	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
661410014986	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
661410014987	Presynaptic Site I dimer interface [polypeptide binding]; other site
661410014988	catalytic residues [active]
661410014989	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
661410014990	Synaptic Flat tetramer interface [polypeptide binding]; other site
661410014991	Synaptic Site I dimer interface [polypeptide binding]; other site
661410014992	DNA binding site [nucleotide binding]
661410014993	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
661410014994	DNA-binding interface [nucleotide binding]; DNA binding site
661410014995	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
661410014996	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
661410014997	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
661410014998	P-loop; other site
661410014999	Magnesium ion binding site [ion binding]; other site
661410015000	Transposase, Mutator family; Region: Transposase_mut; pfam00872
661410015001	MULE transposase domain; Region: MULE; pfam10551
661410015002	Y-family of DNA polymerases; Region: PolY; cl12025
661410015003	DNA binding site [nucleotide binding]
661410015004	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
661410015005	active site
661410015006	NTP binding site [chemical binding]; other site
661410015007	metal binding triad [ion binding]; metal-binding site
661410015008	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
661410015009	TrwC relaxase; Region: TrwC; pfam08751
661410015010	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
661410015011	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
661410015012	AAA domain; Region: AAA_30; pfam13604
661410015013	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
661410015014	putative catalytic site [active]
661410015015	putative metal binding site [ion binding]; other site
661410015016	putative phosphate binding site [ion binding]; other site
661410015017	arsenical pump membrane protein; Provisional; Region: PRK15445
661410015018	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
661410015019	transmembrane helices; other site
661410015020	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
661410015021	ArsC family; Region: ArsC; pfam03960
661410015022	catalytic residues [active]
661410015023	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
661410015024	Low molecular weight phosphatase family; Region: LMWPc; cd00115
661410015025	active site
661410015026	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
661410015027	dimerization interface [polypeptide binding]; other site
661410015028	putative DNA binding site [nucleotide binding]; other site
661410015029	putative Zn2+ binding site [ion binding]; other site
661410015030	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
661410015031	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
661410015032	Helix-turn-helix domain; Region: HTH_28; pfam13518
661410015033	Winged helix-turn helix; Region: HTH_29; pfam13551
661410015034	Homeodomain-like domain; Region: HTH_32; pfam13565
661410015035	DDE superfamily endonuclease; Region: DDE_3; pfam13358
661410015036	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
661410015037	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
661410015038	NAD binding site [chemical binding]; other site
661410015039	homotetramer interface [polypeptide binding]; other site
661410015040	homodimer interface [polypeptide binding]; other site
661410015041	substrate binding site [chemical binding]; other site
661410015042	active site
661410015043	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339