-- dump date 20140619_144549 -- class Genbank::misc_feature -- table misc_feature_note -- id note 460265000001 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 460265000002 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 460265000003 active site 460265000004 dimer interface [polypeptide binding]; other site 460265000005 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 460265000006 Ligand Binding Site [chemical binding]; other site 460265000007 Molecular Tunnel; other site 460265000008 hypothetical protein; Provisional; Region: PRK07236 460265000009 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 460265000010 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 460265000011 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 460265000012 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 460265000013 active site 460265000014 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 460265000015 CoenzymeA binding site [chemical binding]; other site 460265000016 subunit interaction site [polypeptide binding]; other site 460265000017 PHB binding site; other site 460265000018 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265000019 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265000020 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265000021 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265000022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265000023 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265000024 dimerization interface [polypeptide binding]; other site 460265000025 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 460265000026 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 460265000027 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 460265000028 Coenzyme A binding pocket [chemical binding]; other site 460265000029 Phosphotransferase enzyme family; Region: APH; pfam01636 460265000030 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 460265000031 substrate binding site [chemical binding]; other site 460265000032 enolase; Provisional; Region: eno; PRK00077 460265000033 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 460265000034 dimer interface [polypeptide binding]; other site 460265000035 metal binding site [ion binding]; metal-binding site 460265000036 substrate binding pocket [chemical binding]; other site 460265000037 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 460265000038 putative transposase OrfB; Reviewed; Region: PHA02517 460265000039 Transposase; Region: HTH_Tnp_1; cl17663 460265000040 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 460265000041 ParB-like nuclease domain; Region: ParB; smart00470 460265000042 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 460265000043 MerR family regulatory protein; Region: MerR; pfam00376 460265000044 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 460265000045 P-loop; other site 460265000046 Magnesium ion binding site [ion binding]; other site 460265000047 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 460265000048 Magnesium ion binding site [ion binding]; other site 460265000049 Winged helix-turn helix; Region: HTH_29; pfam13551 460265000050 Integrase core domain; Region: rve; pfam00665 460265000051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265000052 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265000053 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265000054 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 460265000055 Helix-turn-helix domain; Region: HTH_36; pfam13730 460265000056 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 460265000057 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 460265000058 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 460265000059 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 460265000060 PYR/PP interface [polypeptide binding]; other site 460265000061 dimer interface [polypeptide binding]; other site 460265000062 TPP binding site [chemical binding]; other site 460265000063 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 460265000064 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 460265000065 TPP-binding site [chemical binding]; other site 460265000066 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 460265000067 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 460265000068 substrate binding site [chemical binding]; other site 460265000069 ATP binding site [chemical binding]; other site 460265000070 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 460265000071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 460265000072 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 460265000073 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 460265000074 DNA interaction; other site 460265000075 Metal-binding active site; metal-binding site 460265000076 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 460265000077 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 460265000078 putative ligand binding site [chemical binding]; other site 460265000079 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 460265000080 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 460265000081 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 460265000082 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 460265000083 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 460265000084 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 460265000085 TM-ABC transporter signature motif; other site 460265000086 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 460265000087 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 460265000088 Walker A/P-loop; other site 460265000089 ATP binding site [chemical binding]; other site 460265000090 Q-loop/lid; other site 460265000091 ABC transporter signature motif; other site 460265000092 Walker B; other site 460265000093 D-loop; other site 460265000094 H-loop/switch region; other site 460265000095 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 460265000096 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 460265000097 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 460265000098 putative ligand binding site [chemical binding]; other site 460265000099 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 460265000100 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 460265000101 DNA binding site [nucleotide binding] 460265000102 domain linker motif; other site 460265000103 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 460265000104 putative ligand binding site [chemical binding]; other site 460265000105 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265000106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265000107 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 460265000108 dimerization interface [polypeptide binding]; other site 460265000109 allantoate amidohydrolase; Reviewed; Region: PRK12893 460265000110 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 460265000111 active site 460265000112 metal binding site [ion binding]; metal-binding site 460265000113 dimer interface [polypeptide binding]; other site 460265000114 ornithine cyclodeaminase; Validated; Region: PRK06141 460265000115 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 460265000116 metabolite-proton symporter; Region: 2A0106; TIGR00883 460265000117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265000118 putative substrate translocation pore; other site 460265000119 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 460265000120 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 460265000121 homotrimer interaction site [polypeptide binding]; other site 460265000122 putative active site [active] 460265000123 hypothetical protein; Provisional; Region: PRK11171 460265000124 Cupin domain; Region: Cupin_2; pfam07883 460265000125 Cupin domain; Region: Cupin_2; pfam07883 460265000126 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 460265000127 ureidoglycolate hydrolase; Provisional; Region: PRK03606 460265000128 Peptidase C13 family; Region: Peptidase_C13; cl02159 460265000129 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265000130 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 460265000131 oligomerisation interface [polypeptide binding]; other site 460265000132 mobile loop; other site 460265000133 roof hairpin; other site 460265000134 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 460265000135 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 460265000136 ring oligomerisation interface [polypeptide binding]; other site 460265000137 ATP/Mg binding site [chemical binding]; other site 460265000138 stacking interactions; other site 460265000139 hinge regions; other site 460265000140 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265000141 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 460265000142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265000143 S-adenosylmethionine binding site [chemical binding]; other site 460265000144 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 460265000145 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 460265000146 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 460265000147 Transposase; Region: DDE_Tnp_ISL3; pfam01610 460265000148 Transposase; Region: DDE_Tnp_ISL3; pfam01610 460265000149 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 460265000150 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 460265000151 DNA binding residues [nucleotide binding] 460265000152 dimer interface [polypeptide binding]; other site 460265000153 copper binding site [ion binding]; other site 460265000154 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 460265000155 metal-binding site [ion binding] 460265000156 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 460265000157 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 460265000158 metal-binding site [ion binding] 460265000159 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 460265000160 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 460265000161 motif II; other site 460265000162 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 460265000163 Integrase core domain; Region: rve; pfam00665 460265000164 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 460265000165 DDE domain; Region: DDE_Tnp_IS240; pfam13610 460265000166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 460265000167 Integrase core domain; Region: rve; pfam00665 460265000168 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 460265000169 classical (c) SDRs; Region: SDR_c; cd05233 460265000170 NAD(P) binding site [chemical binding]; other site 460265000171 active site 460265000172 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265000173 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265000174 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 460265000175 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 460265000176 molybdopterin cofactor binding site [chemical binding]; other site 460265000177 substrate binding site [chemical binding]; other site 460265000178 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 460265000179 molybdopterin cofactor binding site; other site 460265000180 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 460265000181 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 460265000182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265000183 homodimer interface [polypeptide binding]; other site 460265000184 catalytic residue [active] 460265000185 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 460265000186 galactonate dehydratase; Provisional; Region: PRK14017 460265000187 active site pocket [active] 460265000188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265000189 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265000190 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265000191 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 460265000192 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 460265000193 Walker A/P-loop; other site 460265000194 ATP binding site [chemical binding]; other site 460265000195 Q-loop/lid; other site 460265000196 ABC transporter signature motif; other site 460265000197 Walker B; other site 460265000198 D-loop; other site 460265000199 H-loop/switch region; other site 460265000200 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 460265000201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265000202 dimer interface [polypeptide binding]; other site 460265000203 conserved gate region; other site 460265000204 putative PBP binding loops; other site 460265000205 ABC-ATPase subunit interface; other site 460265000206 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 460265000207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265000208 conserved gate region; other site 460265000209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265000210 ABC-ATPase subunit interface; other site 460265000211 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 460265000212 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265000213 substrate binding pocket [chemical binding]; other site 460265000214 membrane-bound complex binding site; other site 460265000215 hinge residues; other site 460265000216 Cupin domain; Region: Cupin_2; cl17218 460265000217 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 460265000218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265000219 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 460265000220 Transposase; Region: HTH_Tnp_1; pfam01527 460265000221 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265000222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265000223 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265000224 Cupin domain; Region: Cupin_2; pfam07883 460265000225 Helix-turn-helix domain; Region: HTH_18; pfam12833 460265000226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265000227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 460265000228 Integrase core domain; Region: rve; pfam00665 460265000229 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 460265000230 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 460265000231 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 460265000232 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 460265000233 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 460265000234 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 460265000235 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 460265000236 metal-binding site [ion binding] 460265000237 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 460265000238 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 460265000239 Multicopper oxidase; Region: Cu-oxidase; pfam00394 460265000240 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 460265000241 Uncharacterized conserved protein [Function unknown]; Region: COG3350 460265000242 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 460265000243 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 460265000244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 460265000245 active site 460265000246 motif I; other site 460265000247 motif II; other site 460265000248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 460265000249 Integrase core domain; Region: rve; pfam00665 460265000250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265000251 putative substrate translocation pore; other site 460265000252 Major Facilitator Superfamily; Region: MFS_1; pfam07690 460265000253 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 460265000254 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 460265000255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265000256 S-adenosylmethionine binding site [chemical binding]; other site 460265000257 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 460265000258 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 460265000259 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 460265000260 CoA-transferase family III; Region: CoA_transf_3; pfam02515 460265000261 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 460265000262 active site 460265000263 catalytic site [active] 460265000264 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 460265000265 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 460265000266 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 460265000267 HTH DNA binding domain; Region: HTH_13; pfam11972 460265000268 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 460265000269 DNA binding site [nucleotide binding] 460265000270 dimer interface [polypeptide binding]; other site 460265000271 active site 460265000272 Int/Topo IB signature motif; other site 460265000273 DNA binding domain, excisionase family; Region: excise; TIGR01764 460265000274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265000275 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265000276 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265000277 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265000278 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265000279 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 460265000280 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265000281 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 460265000282 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 460265000283 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265000284 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 460265000285 GTP cyclohydrolase I; Provisional; Region: PLN03044 460265000286 active site 460265000287 short chain dehydrogenase; Provisional; Region: PRK09134 460265000288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265000289 NAD(P) binding site [chemical binding]; other site 460265000290 active site 460265000291 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 460265000292 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 460265000293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265000294 S-adenosylmethionine binding site [chemical binding]; other site 460265000295 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 460265000296 active site 460265000297 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 460265000298 Catalytic domain of Protein Kinases; Region: PKc; cd00180 460265000299 active site 460265000300 ATP binding site [chemical binding]; other site 460265000301 substrate binding site [chemical binding]; other site 460265000302 activation loop (A-loop); other site 460265000303 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 460265000304 phenylhydantoinase; Validated; Region: PRK08323 460265000305 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 460265000306 tetramer interface [polypeptide binding]; other site 460265000307 active site 460265000308 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 460265000309 classical (c) SDRs; Region: SDR_c; cd05233 460265000310 NAD(P) binding site [chemical binding]; other site 460265000311 active site 460265000312 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 460265000313 extended (e) SDRs; Region: SDR_e; cd08946 460265000314 NAD(P) binding site [chemical binding]; other site 460265000315 active site 460265000316 substrate binding site [chemical binding]; other site 460265000317 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 460265000318 NMT1-like family; Region: NMT1_2; pfam13379 460265000319 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265000320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265000321 DNA-binding site [nucleotide binding]; DNA binding site 460265000322 FCD domain; Region: FCD; pfam07729 460265000323 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 460265000324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265000325 dimer interface [polypeptide binding]; other site 460265000326 conserved gate region; other site 460265000327 putative PBP binding loops; other site 460265000328 ABC-ATPase subunit interface; other site 460265000329 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 460265000330 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 460265000331 Walker A/P-loop; other site 460265000332 ATP binding site [chemical binding]; other site 460265000333 Q-loop/lid; other site 460265000334 ABC transporter signature motif; other site 460265000335 Walker B; other site 460265000336 D-loop; other site 460265000337 H-loop/switch region; other site 460265000338 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 460265000339 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 460265000340 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 460265000341 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 460265000342 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 460265000343 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 460265000344 Ligand binding site [chemical binding]; other site 460265000345 Electron transfer flavoprotein domain; Region: ETF; pfam01012 460265000346 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 460265000347 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 460265000348 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 460265000349 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 460265000350 active site 460265000351 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 460265000352 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 460265000353 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 460265000354 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 460265000355 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265000356 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265000357 Walker A/P-loop; other site 460265000358 ATP binding site [chemical binding]; other site 460265000359 Q-loop/lid; other site 460265000360 ABC transporter signature motif; other site 460265000361 Walker B; other site 460265000362 D-loop; other site 460265000363 H-loop/switch region; other site 460265000364 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265000365 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265000366 Walker A/P-loop; other site 460265000367 ATP binding site [chemical binding]; other site 460265000368 Q-loop/lid; other site 460265000369 ABC transporter signature motif; other site 460265000370 Walker B; other site 460265000371 D-loop; other site 460265000372 H-loop/switch region; other site 460265000373 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265000374 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265000375 TM-ABC transporter signature motif; other site 460265000376 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265000377 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 460265000378 TM-ABC transporter signature motif; other site 460265000379 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265000380 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 460265000381 ligand binding site [chemical binding]; other site 460265000382 Isochorismatase family; Region: Isochorismatase; pfam00857 460265000383 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 460265000384 catalytic triad [active] 460265000385 conserved cis-peptide bond; other site 460265000386 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 460265000387 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 460265000388 tetramer interface [polypeptide binding]; other site 460265000389 active site 460265000390 Mg2+/Mn2+ binding site [ion binding]; other site 460265000391 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265000392 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265000393 DNA-binding site [nucleotide binding]; DNA binding site 460265000394 FCD domain; Region: FCD; pfam07729 460265000395 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 460265000396 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 460265000397 response regulator; Provisional; Region: PRK13435 460265000398 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 460265000399 GAF domain; Region: GAF; pfam01590 460265000400 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 460265000401 HWE histidine kinase; Region: HWE_HK; pfam07536 460265000402 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 460265000403 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265000404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265000405 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265000406 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 460265000407 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 460265000408 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 460265000409 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 460265000410 Peptidase family M23; Region: Peptidase_M23; pfam01551 460265000411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265000412 putative active site [active] 460265000413 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 460265000414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265000415 active site 460265000416 phosphorylation site [posttranslational modification] 460265000417 intermolecular recognition site; other site 460265000418 dimerization interface [polypeptide binding]; other site 460265000419 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 460265000420 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 460265000421 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 460265000422 active site 460265000423 catalytic site [active] 460265000424 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 460265000425 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 460265000426 dimerization interface [polypeptide binding]; other site 460265000427 metal binding site [ion binding]; metal-binding site 460265000428 GAF domain; Region: GAF_3; pfam13492 460265000429 PAS domain S-box; Region: sensory_box; TIGR00229 460265000430 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265000431 putative active site [active] 460265000432 heme pocket [chemical binding]; other site 460265000433 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 460265000434 GAF domain; Region: GAF; cl17456 460265000435 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 460265000436 PAS domain S-box; Region: sensory_box; TIGR00229 460265000437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265000438 putative active site [active] 460265000439 heme pocket [chemical binding]; other site 460265000440 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 460265000441 HWE histidine kinase; Region: HWE_HK; smart00911 460265000442 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 460265000443 Protein of unknown function, DUF; Region: DUF411; cl01142 460265000444 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 460265000445 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 460265000446 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265000447 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265000448 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265000449 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265000450 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265000451 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 460265000452 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 460265000453 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 460265000454 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 460265000455 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 460265000456 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 460265000457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 460265000458 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 460265000459 Walker A/P-loop; other site 460265000460 ATP binding site [chemical binding]; other site 460265000461 Q-loop/lid; other site 460265000462 ABC transporter signature motif; other site 460265000463 Walker B; other site 460265000464 D-loop; other site 460265000465 H-loop/switch region; other site 460265000466 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 460265000467 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 460265000468 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 460265000469 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265000470 non-specific DNA binding site [nucleotide binding]; other site 460265000471 salt bridge; other site 460265000472 sequence-specific DNA binding site [nucleotide binding]; other site 460265000473 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 460265000474 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 460265000475 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 460265000476 Walker A/P-loop; other site 460265000477 ATP binding site [chemical binding]; other site 460265000478 Q-loop/lid; other site 460265000479 ABC transporter signature motif; other site 460265000480 Walker B; other site 460265000481 D-loop; other site 460265000482 H-loop/switch region; other site 460265000483 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 460265000484 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265000485 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265000486 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 460265000487 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 460265000488 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 460265000489 active site pocket [active] 460265000490 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 460265000491 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 460265000492 putative active site [active] 460265000493 putative FMN binding site [chemical binding]; other site 460265000494 putative catalytic residue [active] 460265000495 putative substrate binding site [chemical binding]; other site 460265000496 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 460265000497 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 460265000498 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 460265000499 Walker A/P-loop; other site 460265000500 ATP binding site [chemical binding]; other site 460265000501 Q-loop/lid; other site 460265000502 ABC transporter signature motif; other site 460265000503 Walker B; other site 460265000504 D-loop; other site 460265000505 H-loop/switch region; other site 460265000506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265000507 dimer interface [polypeptide binding]; other site 460265000508 conserved gate region; other site 460265000509 ABC-ATPase subunit interface; other site 460265000510 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 460265000511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265000512 dimer interface [polypeptide binding]; other site 460265000513 conserved gate region; other site 460265000514 putative PBP binding loops; other site 460265000515 ABC-ATPase subunit interface; other site 460265000516 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265000517 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 460265000518 substrate binding pocket [chemical binding]; other site 460265000519 membrane-bound complex binding site; other site 460265000520 hinge residues; other site 460265000521 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 460265000522 hydroxyglutarate oxidase; Provisional; Region: PRK11728 460265000523 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265000524 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 460265000525 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 460265000526 putative dimerization interface [polypeptide binding]; other site 460265000527 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 460265000528 MgtC family; Region: MgtC; pfam02308 460265000529 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 460265000530 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 460265000531 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 460265000532 nudix motif; other site 460265000533 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 460265000534 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 460265000535 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265000536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265000537 active site 460265000538 phosphorylation site [posttranslational modification] 460265000539 intermolecular recognition site; other site 460265000540 dimerization interface [polypeptide binding]; other site 460265000541 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 460265000542 DNA binding residues [nucleotide binding] 460265000543 dimerization interface [polypeptide binding]; other site 460265000544 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 460265000545 Ca2+ binding site [ion binding]; other site 460265000546 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265000547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265000548 active site 460265000549 phosphorylation site [posttranslational modification] 460265000550 intermolecular recognition site; other site 460265000551 dimerization interface [polypeptide binding]; other site 460265000552 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265000553 DNA binding residues [nucleotide binding] 460265000554 dimerization interface [polypeptide binding]; other site 460265000555 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 460265000556 Uncharacterized conserved protein [Function unknown]; Region: COG3391 460265000557 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 460265000558 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 460265000559 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 460265000560 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 460265000561 putative hydrophobic ligand binding site [chemical binding]; other site 460265000562 protein interface [polypeptide binding]; other site 460265000563 gate; other site 460265000564 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 460265000565 metal ion-dependent adhesion site (MIDAS); other site 460265000566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 460265000567 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 460265000568 metal ion-dependent adhesion site (MIDAS); other site 460265000569 Protein of unknown function DUF58; Region: DUF58; pfam01882 460265000570 MoxR-like ATPases [General function prediction only]; Region: COG0714 460265000571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265000572 Walker A motif; other site 460265000573 ATP binding site [chemical binding]; other site 460265000574 Walker B motif; other site 460265000575 arginine finger; other site 460265000576 Methanol dehydrogenase beta subunit; Region: MDH; pfam02315 460265000577 cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872 460265000578 methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870 460265000579 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 460265000580 substrate binding pocket [chemical binding]; other site 460265000581 membrane-bound complex binding site; other site 460265000582 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 460265000583 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 460265000584 Trp docking motif [polypeptide binding]; other site 460265000585 dimer interface [polypeptide binding]; other site 460265000586 active site 460265000587 small subunit binding site [polypeptide binding]; other site 460265000588 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 460265000589 inhibitor site; inhibition site 460265000590 active site 460265000591 dimer interface [polypeptide binding]; other site 460265000592 catalytic residue [active] 460265000593 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265000594 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265000595 putative ligand binding site [chemical binding]; other site 460265000596 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 460265000597 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 460265000598 active site 460265000599 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265000600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265000601 DNA-binding site [nucleotide binding]; DNA binding site 460265000602 FCD domain; Region: FCD; pfam07729 460265000603 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 460265000604 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 460265000605 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265000606 substrate binding site [chemical binding]; other site 460265000607 oxyanion hole (OAH) forming residues; other site 460265000608 trimer interface [polypeptide binding]; other site 460265000609 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 460265000610 Coenzyme A transferase; Region: CoA_trans; smart00882 460265000611 Coenzyme A transferase; Region: CoA_trans; cl17247 460265000612 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265000613 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265000614 Walker A/P-loop; other site 460265000615 ATP binding site [chemical binding]; other site 460265000616 Q-loop/lid; other site 460265000617 ABC transporter signature motif; other site 460265000618 Walker B; other site 460265000619 D-loop; other site 460265000620 H-loop/switch region; other site 460265000621 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265000622 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265000623 Walker A/P-loop; other site 460265000624 ATP binding site [chemical binding]; other site 460265000625 Q-loop/lid; other site 460265000626 ABC transporter signature motif; other site 460265000627 Walker B; other site 460265000628 D-loop; other site 460265000629 H-loop/switch region; other site 460265000630 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265000631 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 460265000632 TM-ABC transporter signature motif; other site 460265000633 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265000634 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265000635 TM-ABC transporter signature motif; other site 460265000636 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265000637 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265000638 DNA-binding site [nucleotide binding]; DNA binding site 460265000639 FCD domain; Region: FCD; pfam07729 460265000640 benzoate transport; Region: 2A0115; TIGR00895 460265000641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265000642 putative substrate translocation pore; other site 460265000643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265000644 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 460265000645 oligomerization interface [polypeptide binding]; other site 460265000646 active site 460265000647 metal binding site [ion binding]; metal-binding site 460265000648 Methyltransferase domain; Region: Methyltransf_23; pfam13489 460265000649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265000650 S-adenosylmethionine binding site [chemical binding]; other site 460265000651 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 460265000652 Uncharacterized conserved protein [Function unknown]; Region: COG1262 460265000653 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 460265000654 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 460265000655 Sulfatase; Region: Sulfatase; pfam00884 460265000656 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 460265000657 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 460265000658 motif II; other site 460265000659 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 460265000660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265000661 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265000662 HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3 460265000663 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 460265000664 active site 460265000665 motif I; other site 460265000666 motif II; other site 460265000667 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 460265000668 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 460265000669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 460265000670 Predicted kinase [General function prediction only]; Region: COG0645 460265000671 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 460265000672 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 460265000673 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 460265000674 Soluble P-type ATPase [General function prediction only]; Region: COG4087 460265000675 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 460265000676 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 460265000677 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 460265000678 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 460265000679 acyl-activating enzyme (AAE) consensus motif; other site 460265000680 active site 460265000681 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 460265000682 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 460265000683 putative acyl-acceptor binding pocket; other site 460265000684 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 460265000685 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 460265000686 putative active site [active] 460265000687 putative metal binding site [ion binding]; other site 460265000688 Putative integral membrane protein DUF46; Region: DUF46; cl17511 460265000689 Response regulator receiver domain; Region: Response_reg; pfam00072 460265000690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265000691 active site 460265000692 phosphorylation site [posttranslational modification] 460265000693 intermolecular recognition site; other site 460265000694 dimerization interface [polypeptide binding]; other site 460265000695 Domain of unknown function DUF302; Region: DUF302; pfam03625 460265000696 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 460265000697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265000698 NAD(P) binding site [chemical binding]; other site 460265000699 active site 460265000700 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265000701 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265000702 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 460265000703 dimerization interface [polypeptide binding]; other site 460265000704 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 460265000705 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 460265000706 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 460265000707 nucleophile elbow; other site 460265000708 Patatin phospholipase; Region: DUF3734; pfam12536 460265000709 Transposase domain (DUF772); Region: DUF772; pfam05598 460265000710 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265000711 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 460265000712 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 460265000713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265000714 DNA-binding site [nucleotide binding]; DNA binding site 460265000715 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 460265000716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 460265000717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265000718 homodimer interface [polypeptide binding]; other site 460265000719 catalytic residue [active] 460265000720 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265000721 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265000722 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 460265000723 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 460265000724 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 460265000725 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 460265000726 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 460265000727 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 460265000728 Walker A/P-loop; other site 460265000729 ATP binding site [chemical binding]; other site 460265000730 Q-loop/lid; other site 460265000731 ABC transporter signature motif; other site 460265000732 Walker B; other site 460265000733 D-loop; other site 460265000734 H-loop/switch region; other site 460265000735 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 460265000736 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 460265000737 Walker A/P-loop; other site 460265000738 ATP binding site [chemical binding]; other site 460265000739 Q-loop/lid; other site 460265000740 ABC transporter signature motif; other site 460265000741 Walker B; other site 460265000742 D-loop; other site 460265000743 H-loop/switch region; other site 460265000744 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265000745 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265000746 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 460265000747 oligomeric interface; other site 460265000748 putative active site [active] 460265000749 homodimer interface [polypeptide binding]; other site 460265000750 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 460265000751 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265000752 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265000753 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265000754 ligand binding site [chemical binding]; other site 460265000755 flexible hinge region; other site 460265000756 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 460265000757 putative switch regulator; other site 460265000758 non-specific DNA interactions [nucleotide binding]; other site 460265000759 DNA binding site [nucleotide binding] 460265000760 sequence specific DNA binding site [nucleotide binding]; other site 460265000761 putative cAMP binding site [chemical binding]; other site 460265000762 Cytochrome c; Region: Cytochrom_C; cl11414 460265000763 Cytochrome c; Region: Cytochrom_C; cl11414 460265000764 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 460265000765 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 460265000766 Cytochrome c; Region: Cytochrom_C; pfam00034 460265000767 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 460265000768 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 460265000769 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 460265000770 Putative D-pathway homolog; other site 460265000771 Low-spin heme binding site [chemical binding]; other site 460265000772 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 460265000773 Subunit I/II interface [polypeptide binding]; other site 460265000774 Putative Q-pathway; other site 460265000775 Putative alternate electron transfer pathway; other site 460265000776 Putative water exit pathway; other site 460265000777 Binuclear center (active site) [active] 460265000778 Putative K-pathway homolog; other site 460265000779 Putative proton exit pathway; other site 460265000780 Subunit I/IIa interface [polypeptide binding]; other site 460265000781 Electron transfer pathway; other site 460265000782 Cytochrome c553 [Energy production and conversion]; Region: COG2863 460265000783 Cytochrome c; Region: Cytochrom_C; cl11414 460265000784 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265000785 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265000786 Transcriptional regulators [Transcription]; Region: PurR; COG1609 460265000787 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 460265000788 DNA binding site [nucleotide binding] 460265000789 domain linker motif; other site 460265000790 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 460265000791 putative dimerization interface [polypeptide binding]; other site 460265000792 putative ligand binding site [chemical binding]; other site 460265000793 Transcriptional regulators [Transcription]; Region: FadR; COG2186 460265000794 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265000795 DNA-binding site [nucleotide binding]; DNA binding site 460265000796 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 460265000797 Protein of unknown function, DUF1537; Region: DUF1537; pfam07005 460265000798 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 460265000799 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 460265000800 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 460265000801 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 460265000802 active site 460265000803 NAD binding site [chemical binding]; other site 460265000804 metal binding site [ion binding]; metal-binding site 460265000805 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 460265000806 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 460265000807 inhibitor site; inhibition site 460265000808 active site 460265000809 dimer interface [polypeptide binding]; other site 460265000810 catalytic residue [active] 460265000811 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 460265000812 Na binding site [ion binding]; other site 460265000813 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 460265000814 BNR repeat-like domain; Region: BNR_2; pfam13088 460265000815 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 460265000816 classical (c) SDRs; Region: SDR_c; cd05233 460265000817 NAD(P) binding site [chemical binding]; other site 460265000818 active site 460265000819 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 460265000820 EamA-like transporter family; Region: EamA; pfam00892 460265000821 EamA-like transporter family; Region: EamA; pfam00892 460265000822 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265000823 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265000824 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265000825 radical SAM protein, TIGR01212 family; Region: TIGR01212 460265000826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265000827 TPR motif; other site 460265000828 TPR repeat; Region: TPR_11; pfam13414 460265000829 binding surface 460265000830 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265000831 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265000832 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265000833 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 460265000834 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 460265000835 hydrophobic ligand binding site; other site 460265000836 CHRD domain; Region: CHRD; pfam07452 460265000837 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 460265000838 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 460265000839 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 460265000840 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 460265000841 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 460265000842 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 460265000843 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 460265000844 putative active site [active] 460265000845 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 460265000846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265000847 Walker A/P-loop; other site 460265000848 ATP binding site [chemical binding]; other site 460265000849 Q-loop/lid; other site 460265000850 ABC transporter signature motif; other site 460265000851 Walker B; other site 460265000852 D-loop; other site 460265000853 H-loop/switch region; other site 460265000854 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 460265000855 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265000856 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265000857 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 460265000858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265000859 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265000860 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265000861 EamA-like transporter family; Region: EamA; cl17759 460265000862 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 460265000863 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265000864 Methyltransferase domain; Region: Methyltransf_23; pfam13489 460265000865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265000866 S-adenosylmethionine binding site [chemical binding]; other site 460265000867 Predicted membrane protein [Function unknown]; Region: COG2259 460265000868 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 460265000869 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 460265000870 metal binding site [ion binding]; metal-binding site 460265000871 dimer interface [polypeptide binding]; other site 460265000872 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 460265000873 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 460265000874 dimer interface [polypeptide binding]; other site 460265000875 active site 460265000876 heme binding site [chemical binding]; other site 460265000877 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 460265000878 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 460265000879 active site 460265000880 Transcription termination factor nusG; Region: NusG; pfam02357 460265000881 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 460265000882 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265000883 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 460265000884 Winged helix-turn helix; Region: HTH_29; pfam13551 460265000885 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265000886 Predicted transcriptional regulator [Transcription]; Region: COG4957 460265000887 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265000888 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265000889 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265000890 Uncharacterized conserved protein [Function unknown]; Region: COG5361 460265000891 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 460265000892 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 460265000893 Phasin protein; Region: Phasin_2; cl11491 460265000894 Protein of unknown function (DUF938); Region: DUF938; pfam06080 460265000895 Phytochelatin synthase; Region: Phytochelatin; pfam05023 460265000896 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 460265000897 MarR family; Region: MarR_2; pfam12802 460265000898 Transcriptional regulators [Transcription]; Region: MarR; COG1846 460265000899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 460265000900 Coenzyme A binding pocket [chemical binding]; other site 460265000901 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 460265000902 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 460265000903 phenol 2-monooxygenase; Provisional; Region: PRK08294 460265000904 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 460265000905 Phenol hydroxylase, C-terminal dimerisation domain; Region: Phe_hydrox_dim; pfam07976 460265000906 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 460265000907 EamA-like transporter family; Region: EamA; pfam00892 460265000908 EamA-like transporter family; Region: EamA; pfam00892 460265000909 TPR repeat; Region: TPR_11; pfam13414 460265000910 Tetratricopeptide repeat; Region: TPR_1; pfam00515 460265000911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265000912 binding surface 460265000913 TPR motif; other site 460265000914 TPR repeat; Region: TPR_11; pfam13414 460265000915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265000916 binding surface 460265000917 TPR motif; other site 460265000918 TPR repeat; Region: TPR_11; pfam13414 460265000919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265000920 binding surface 460265000921 TPR repeat; Region: TPR_11; pfam13414 460265000922 TPR motif; other site 460265000923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265000924 binding surface 460265000925 TPR repeat; Region: TPR_11; pfam13414 460265000926 TPR motif; other site 460265000927 TPR repeat; Region: TPR_11; pfam13414 460265000928 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 460265000929 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 460265000930 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 460265000931 FAD binding domain; Region: FAD_binding_4; pfam01565 460265000932 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 460265000933 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 460265000934 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 460265000935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265000936 D-galactonate transporter; Region: 2A0114; TIGR00893 460265000937 putative substrate translocation pore; other site 460265000938 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 460265000939 active site 2 [active] 460265000940 active site 1 [active] 460265000941 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 460265000942 CoA-transferase family III; Region: CoA_transf_3; pfam02515 460265000943 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 460265000944 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265000945 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 460265000946 acyl-activating enzyme (AAE) consensus motif; other site 460265000947 acyl-activating enzyme (AAE) consensus motif; other site 460265000948 putative AMP binding site [chemical binding]; other site 460265000949 putative active site [active] 460265000950 putative CoA binding site [chemical binding]; other site 460265000951 Transcriptional regulator [Transcription]; Region: IclR; COG1414 460265000952 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 460265000953 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 460265000954 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265000955 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 460265000956 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 460265000957 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 460265000958 active site 460265000959 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 460265000960 DNA methylase; Region: N6_N4_Mtase; pfam01555 460265000961 FecCD transport family; Region: FecCD; pfam01032 460265000962 putative PBP binding regions; other site 460265000963 ABC-ATPase subunit interface; other site 460265000964 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 460265000965 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 460265000966 Walker A/P-loop; other site 460265000967 ATP binding site [chemical binding]; other site 460265000968 Q-loop/lid; other site 460265000969 ABC transporter signature motif; other site 460265000970 Walker B; other site 460265000971 D-loop; other site 460265000972 H-loop/switch region; other site 460265000973 LysR family transcriptional regulator; Provisional; Region: PRK14997 460265000974 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265000975 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 460265000976 putative effector binding pocket; other site 460265000977 putative dimerization interface [polypeptide binding]; other site 460265000978 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 460265000979 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 460265000980 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 460265000981 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265000982 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265000983 multidrug efflux protein; Reviewed; Region: PRK09579 460265000984 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 460265000985 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 460265000986 dimer interface [polypeptide binding]; other site 460265000987 active site 460265000988 enoyl-CoA hydratase; Provisional; Region: PRK05995 460265000989 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265000990 substrate binding site [chemical binding]; other site 460265000991 oxyanion hole (OAH) forming residues; other site 460265000992 trimer interface [polypeptide binding]; other site 460265000993 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 460265000994 putative Zn2+ binding site [ion binding]; other site 460265000995 putative DNA binding site [nucleotide binding]; other site 460265000996 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 460265000997 active site 460265000998 metal binding site [ion binding]; metal-binding site 460265000999 interdomain interaction site; other site 460265001000 Domain of unknown function (DUF927); Region: DUF927; pfam06048 460265001001 hypothetical protein; Validated; Region: PRK07078 460265001002 Helix-turn-helix domain; Region: HTH_17; pfam12728 460265001003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265001004 non-specific DNA binding site [nucleotide binding]; other site 460265001005 salt bridge; other site 460265001006 sequence-specific DNA binding site [nucleotide binding]; other site 460265001007 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 460265001008 Magnesium ion binding site [ion binding]; other site 460265001009 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 460265001010 Abi-like protein; Region: Abi_2; pfam07751 460265001011 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 460265001012 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 460265001013 catalytic residues [active] 460265001014 catalytic nucleophile [active] 460265001015 Recombinase; Region: Recombinase; pfam07508 460265001016 Protein of unknown function DUF262; Region: DUF262; pfam03235 460265001017 Uncharacterized conserved protein [Function unknown]; Region: COG1479 460265001018 Protein of unknown function DUF262; Region: DUF262; pfam03235 460265001019 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 460265001020 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 460265001021 multiple promoter invertase; Provisional; Region: mpi; PRK13413 460265001022 catalytic residues [active] 460265001023 catalytic nucleophile [active] 460265001024 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 460265001025 DNA-binding interface [nucleotide binding]; DNA binding site 460265001026 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 460265001027 Helix-turn-helix domain; Region: HTH_17; pfam12728 460265001028 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 460265001029 nucleotide binding site [chemical binding]; other site 460265001030 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 460265001031 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 460265001032 polymerase nucleotide-binding site; other site 460265001033 DNA-binding residues [nucleotide binding]; DNA binding site 460265001034 nucleotide binding site [chemical binding]; other site 460265001035 primase nucleotide-binding site [nucleotide binding]; other site 460265001036 Virulence-associated protein E; Region: VirE; pfam05272 460265001037 Helix-turn-helix domain; Region: HTH_17; cl17695 460265001038 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 460265001039 Sulfatase; Region: Sulfatase; pfam00884 460265001040 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 460265001041 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 460265001042 Low affinity iron permease; Region: Iron_permease; cl12096 460265001043 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 460265001044 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 460265001045 dimer interface [polypeptide binding]; other site 460265001046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 460265001047 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 460265001048 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 460265001049 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 460265001050 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 460265001051 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 460265001052 NADH(P)-binding; Region: NAD_binding_10; pfam13460 460265001053 putative NAD(P) binding site [chemical binding]; other site 460265001054 active site 460265001055 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 460265001056 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 460265001057 N-terminal plug; other site 460265001058 ligand-binding site [chemical binding]; other site 460265001059 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 460265001060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 460265001061 Transposase; Region: DDE_Tnp_ISL3; pfam01610 460265001062 Transposase; Region: DDE_Tnp_ISL3; pfam01610 460265001063 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 460265001064 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 460265001065 Toprim domain; Region: Toprim_3; pfam13362 460265001066 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265001067 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 460265001068 putative active site [active] 460265001069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 460265001070 ParB-like nuclease domain; Region: ParBc; pfam02195 460265001071 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 460265001072 putative C-terminal domain interface [polypeptide binding]; other site 460265001073 putative GSH binding site (G-site) [chemical binding]; other site 460265001074 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 460265001075 putative dimer interface [polypeptide binding]; other site 460265001076 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 460265001077 dimer interface [polypeptide binding]; other site 460265001078 N-terminal domain interface [polypeptide binding]; other site 460265001079 putative substrate binding pocket (H-site) [chemical binding]; other site 460265001080 Protein of unknown function (DUF419); Region: DUF419; pfam04237 460265001081 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 460265001082 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 460265001083 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 460265001084 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265001085 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265001086 catalytic residue [active] 460265001087 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 460265001088 Creatinine amidohydrolase; Region: Creatininase; pfam02633 460265001089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265001090 Major Facilitator Superfamily; Region: MFS_1; pfam07690 460265001091 putative substrate translocation pore; other site 460265001092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265001093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265001094 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 460265001095 succinic semialdehyde dehydrogenase; Region: PLN02278 460265001096 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 460265001097 tetramerization interface [polypeptide binding]; other site 460265001098 NAD(P) binding site [chemical binding]; other site 460265001099 catalytic residues [active] 460265001100 acetolactate synthase; Reviewed; Region: PRK08322 460265001101 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 460265001102 PYR/PP interface [polypeptide binding]; other site 460265001103 dimer interface [polypeptide binding]; other site 460265001104 TPP binding site [chemical binding]; other site 460265001105 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 460265001106 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 460265001107 TPP-binding site [chemical binding]; other site 460265001108 dimer interface [polypeptide binding]; other site 460265001109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265001110 D-galactonate transporter; Region: 2A0114; TIGR00893 460265001111 putative substrate translocation pore; other site 460265001112 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265001113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265001114 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265001115 dimerization interface [polypeptide binding]; other site 460265001116 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 460265001117 Amidohydrolase; Region: Amidohydro_2; pfam04909 460265001118 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 460265001119 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 460265001120 active site 460265001121 citrylCoA binding site [chemical binding]; other site 460265001122 oxalacetate binding site [chemical binding]; other site 460265001123 coenzyme A binding site [chemical binding]; other site 460265001124 catalytic triad [active] 460265001125 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 460265001126 CoA-transferase family III; Region: CoA_transf_3; pfam02515 460265001127 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 460265001128 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 460265001129 transmembrane helices; other site 460265001130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 460265001131 DDE domain; Region: DDE_Tnp_IS240; pfam13610 460265001132 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 460265001133 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 460265001134 active site 460265001135 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 460265001136 Strictosidine synthase; Region: Str_synth; pfam03088 460265001137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265001138 putative substrate translocation pore; other site 460265001139 hypothetical protein; Validated; Region: PRK06201 460265001140 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 460265001141 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 460265001142 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 460265001143 NAD binding site [chemical binding]; other site 460265001144 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 460265001145 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 460265001146 FAD binding domain; Region: FAD_binding_4; pfam01565 460265001147 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 460265001148 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 460265001149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265001150 putative substrate translocation pore; other site 460265001151 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 460265001152 Transcriptional regulator [Transcription]; Region: IclR; COG1414 460265001153 Bacterial transcriptional regulator; Region: IclR; pfam01614 460265001154 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265001155 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265001156 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 460265001157 putative effector binding pocket; other site 460265001158 putative dimerization interface [polypeptide binding]; other site 460265001159 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 460265001160 classical (c) SDRs; Region: SDR_c; cd05233 460265001161 NAD(P) binding site [chemical binding]; other site 460265001162 active site 460265001163 Uncharacterized conserved protein [Function unknown]; Region: COG4925 460265001164 short chain dehydrogenase; Provisional; Region: PRK06172 460265001165 classical (c) SDRs; Region: SDR_c; cd05233 460265001166 NAD(P) binding site [chemical binding]; other site 460265001167 active site 460265001168 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265001169 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265001170 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 460265001171 putative effector binding pocket; other site 460265001172 putative dimerization interface [polypeptide binding]; other site 460265001173 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 460265001174 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265001175 catalytic loop [active] 460265001176 iron binding site [ion binding]; other site 460265001177 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 460265001178 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 460265001179 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 460265001180 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 460265001181 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 460265001182 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265001183 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 460265001184 RibD C-terminal domain; Region: RibD_C; cl17279 460265001185 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 460265001186 putative addiction module antidote; Region: doc_partner; TIGR02609 460265001187 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 460265001188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265001189 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265001190 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265001191 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265001192 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265001193 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265001194 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265001195 SPW repeat; Region: SPW; pfam03779 460265001196 CheB methylesterase; Region: CheB_methylest; pfam01339 460265001197 Predicted membrane protein [Function unknown]; Region: COG2855 460265001198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265001199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265001200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 460265001201 dimerization interface [polypeptide binding]; other site 460265001202 Winged helix-turn helix; Region: HTH_29; pfam13551 460265001203 Homeodomain-like domain; Region: HTH_23; pfam13384 460265001204 Homeodomain-like domain; Region: HTH_32; pfam13565 460265001205 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 460265001206 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265001207 catalytic loop [active] 460265001208 iron binding site [ion binding]; other site 460265001209 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 460265001210 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 460265001211 [4Fe-4S] binding site [ion binding]; other site 460265001212 molybdopterin cofactor binding site; other site 460265001213 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 460265001214 molybdopterin cofactor binding site; other site 460265001215 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 460265001216 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 460265001217 putative dimer interface [polypeptide binding]; other site 460265001218 [2Fe-2S] cluster binding site [ion binding]; other site 460265001219 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 460265001220 SLBB domain; Region: SLBB; pfam10531 460265001221 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 460265001222 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 460265001223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265001224 benzoate transport; Region: 2A0115; TIGR00895 460265001225 putative substrate translocation pore; other site 460265001226 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 460265001227 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 460265001228 [2Fe-2S] cluster binding site [ion binding]; other site 460265001229 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 460265001230 alpha subunit interface [polypeptide binding]; other site 460265001231 active site 460265001232 substrate binding site [chemical binding]; other site 460265001233 Fe binding site [ion binding]; other site 460265001234 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 460265001235 inter-subunit interface; other site 460265001236 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 460265001237 [2Fe-2S] cluster binding site [ion binding]; other site 460265001238 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 460265001239 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265001240 catalytic loop [active] 460265001241 iron binding site [ion binding]; other site 460265001242 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 460265001243 FAD binding pocket [chemical binding]; other site 460265001244 conserved FAD binding motif [chemical binding]; other site 460265001245 phosphate binding motif [ion binding]; other site 460265001246 beta-alpha-beta structure motif; other site 460265001247 NAD binding pocket [chemical binding]; other site 460265001248 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 460265001249 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 460265001250 sulfite oxidase; Provisional; Region: PLN00177 460265001251 Moco binding site; other site 460265001252 metal coordination site [ion binding]; other site 460265001253 Cytochrome c; Region: Cytochrom_C; cl11414 460265001254 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 460265001255 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 460265001256 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 460265001257 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 460265001258 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 460265001259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 460265001260 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 460265001261 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 460265001262 Transposase; Region: HTH_Tnp_1; pfam01527 460265001263 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 460265001264 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 460265001265 Transposase; Region: HTH_Tnp_1; cl17663 460265001266 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 460265001267 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 460265001268 active site 460265001269 catalytic residues [active] 460265001270 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 460265001271 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 460265001272 HTH-like domain; Region: HTH_21; pfam13276 460265001273 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 460265001274 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 460265001275 nucleophile elbow; other site 460265001276 Patatin phospholipase; Region: DUF3734; pfam12536 460265001277 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 460265001278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265001279 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265001280 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265001281 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265001282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265001283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 460265001284 dimerization interface [polypeptide binding]; other site 460265001285 choline dehydrogenase; Validated; Region: PRK02106 460265001286 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 460265001287 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 460265001288 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 460265001289 NAD(P) binding site [chemical binding]; other site 460265001290 catalytic residues [active] 460265001291 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 460265001292 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265001293 Walker A/P-loop; other site 460265001294 ATP binding site [chemical binding]; other site 460265001295 Q-loop/lid; other site 460265001296 ABC transporter signature motif; other site 460265001297 Walker B; other site 460265001298 D-loop; other site 460265001299 H-loop/switch region; other site 460265001300 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 460265001301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265001302 dimer interface [polypeptide binding]; other site 460265001303 conserved gate region; other site 460265001304 putative PBP binding loops; other site 460265001305 ABC-ATPase subunit interface; other site 460265001306 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 460265001307 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 460265001308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265001309 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 460265001310 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 460265001311 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 460265001312 NAD(P) binding site [chemical binding]; other site 460265001313 catalytic residues [active] 460265001314 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 460265001315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 460265001316 PIN domain; Region: PIN_3; pfam13470 460265001317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 460265001318 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 460265001319 dimer interface [polypeptide binding]; other site 460265001320 Transposase domain (DUF772); Region: DUF772; pfam05598 460265001321 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265001322 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265001323 non-specific DNA binding site [nucleotide binding]; other site 460265001324 salt bridge; other site 460265001325 sequence-specific DNA binding site [nucleotide binding]; other site 460265001326 HNH endonuclease; Region: HNH_5; pfam14279 460265001327 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 460265001328 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 460265001329 catalytic residues [active] 460265001330 catalytic nucleophile [active] 460265001331 LabA_like proteins; Region: LabA_like; cd06167 460265001332 putative metal binding site [ion binding]; other site 460265001333 hypothetical protein; Region: PHA01623 460265001334 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265001335 Winged helix-turn helix; Region: HTH_29; pfam13551 460265001336 Homeodomain-like domain; Region: HTH_32; pfam13565 460265001337 Winged helix-turn helix; Region: HTH_33; pfam13592 460265001338 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 460265001339 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 460265001340 Protein of unknown function, DUF417; Region: DUF417; cl01162 460265001341 Cupin domain; Region: Cupin_2; pfam07883 460265001342 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 460265001343 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 460265001344 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 460265001345 C-terminal domain interface [polypeptide binding]; other site 460265001346 GSH binding site (G-site) [chemical binding]; other site 460265001347 dimer interface [polypeptide binding]; other site 460265001348 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 460265001349 dimer interface [polypeptide binding]; other site 460265001350 N-terminal domain interface [polypeptide binding]; other site 460265001351 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 460265001352 classical (c) SDRs; Region: SDR_c; cd05233 460265001353 NAD(P) binding site [chemical binding]; other site 460265001354 active site 460265001355 Uncharacterized conserved protein [Function unknown]; Region: COG2128 460265001356 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 460265001357 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 460265001358 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 460265001359 dimer interface [polypeptide binding]; other site 460265001360 FMN binding site [chemical binding]; other site 460265001361 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 460265001362 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 460265001363 putative NAD(P) binding site [chemical binding]; other site 460265001364 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 460265001365 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265001366 Winged helix-turn helix; Region: HTH_29; pfam13551 460265001367 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265001368 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 460265001369 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265001370 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 460265001371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265001372 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265001373 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265001374 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 460265001375 Integrase core domain; Region: rve; pfam00665 460265001376 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 460265001377 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 460265001378 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265001379 catalytic loop [active] 460265001380 iron binding site [ion binding]; other site 460265001381 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 460265001382 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265001383 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 460265001384 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 460265001385 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265001386 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 460265001387 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 460265001388 active site 460265001389 DNA binding site [nucleotide binding] 460265001390 Int/Topo IB signature motif; other site 460265001391 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 460265001392 Putative transposase; Region: Y2_Tnp; pfam04986 460265001393 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265001394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 460265001395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265001396 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265001397 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265001398 muropeptide transporter; Validated; Region: ampG; cl17669 460265001399 muropeptide transporter; Reviewed; Region: ampG; PRK11902 460265001400 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 460265001401 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 460265001402 Bacterial transcriptional regulator; Region: IclR; pfam01614 460265001403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 460265001404 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 460265001405 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 460265001406 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265001407 catalytic loop [active] 460265001408 iron binding site [ion binding]; other site 460265001409 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 460265001410 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 460265001411 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 460265001412 alpha subunit interface [polypeptide binding]; other site 460265001413 active site 460265001414 substrate binding site [chemical binding]; other site 460265001415 Fe binding site [ion binding]; other site 460265001416 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 460265001417 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 460265001418 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 460265001419 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 460265001420 putative FMN binding site [chemical binding]; other site 460265001421 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265001422 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265001423 putative ligand binding site [chemical binding]; other site 460265001424 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265001425 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265001426 The C-terminal substrate binding domain of LysR-type transcriptional regulator PnbR, which is involved in regulating the pnb genes encoding enzymes for 4-nitrobenzoate catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_PnbR; cd08469 460265001427 putative substrate binding pocket [chemical binding]; other site 460265001428 putative dimerization interface [polypeptide binding]; other site 460265001429 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 460265001430 Integrase core domain; Region: rve; pfam00665 460265001431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265001432 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265001433 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265001434 DNA-binding site [nucleotide binding]; DNA binding site 460265001435 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 460265001436 ParB-like nuclease domain; Region: ParBc; cl02129 460265001437 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 460265001438 HTH DNA binding domain; Region: HTH_13; pfam11972 460265001439 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 460265001440 DNA binding site [nucleotide binding] 460265001441 dimer interface [polypeptide binding]; other site 460265001442 active site 460265001443 Int/Topo IB signature motif; other site 460265001444 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 460265001445 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265001446 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 460265001447 dimerization interface [polypeptide binding]; other site 460265001448 substrate binding pocket [chemical binding]; other site 460265001449 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 460265001450 aldehyde dehydrogenase family 7 member; Region: PLN02315 460265001451 tetrameric interface [polypeptide binding]; other site 460265001452 NAD binding site [chemical binding]; other site 460265001453 catalytic residues [active] 460265001454 aspartate aminotransferase; Provisional; Region: PRK05764 460265001455 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 460265001456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265001457 homodimer interface [polypeptide binding]; other site 460265001458 catalytic residue [active] 460265001459 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 460265001460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 460265001461 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 460265001462 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265001463 non-specific DNA binding site [nucleotide binding]; other site 460265001464 salt bridge; other site 460265001465 sequence-specific DNA binding site [nucleotide binding]; other site 460265001466 Cupin domain; Region: Cupin_2; pfam07883 460265001467 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 460265001468 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 460265001469 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 460265001470 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 460265001471 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 460265001472 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 460265001473 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 460265001474 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 460265001475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265001476 ABC-ATPase subunit interface; other site 460265001477 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 460265001478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265001479 dimer interface [polypeptide binding]; other site 460265001480 conserved gate region; other site 460265001481 putative PBP binding loops; other site 460265001482 ABC-ATPase subunit interface; other site 460265001483 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 460265001484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265001485 Walker A/P-loop; other site 460265001486 ATP binding site [chemical binding]; other site 460265001487 Q-loop/lid; other site 460265001488 ABC transporter signature motif; other site 460265001489 Walker B; other site 460265001490 D-loop; other site 460265001491 H-loop/switch region; other site 460265001492 TOBE domain; Region: TOBE_2; pfam08402 460265001493 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 460265001494 FAD binding domain; Region: FAD_binding_4; pfam01565 460265001495 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 460265001496 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 460265001497 inhibitor site; inhibition site 460265001498 active site 460265001499 dimer interface [polypeptide binding]; other site 460265001500 catalytic residue [active] 460265001501 Integrase core domain; Region: rve_3; pfam13683 460265001502 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 460265001503 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 460265001504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265001505 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 460265001506 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 460265001507 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 460265001508 ethanolamine permease; Region: 2A0305; TIGR00908 460265001509 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 460265001510 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265001511 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265001512 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265001513 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 460265001514 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 460265001515 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 460265001516 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 460265001517 putative C-terminal domain interface [polypeptide binding]; other site 460265001518 putative GSH binding site (G-site) [chemical binding]; other site 460265001519 putative dimer interface [polypeptide binding]; other site 460265001520 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 460265001521 putative N-terminal domain interface [polypeptide binding]; other site 460265001522 putative dimer interface [polypeptide binding]; other site 460265001523 putative substrate binding pocket (H-site) [chemical binding]; other site 460265001524 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265001525 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265001526 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 460265001527 putative effector binding pocket; other site 460265001528 putative dimerization interface [polypeptide binding]; other site 460265001529 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 460265001530 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 460265001531 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 460265001532 catalytic residue [active] 460265001533 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265001534 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265001535 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 460265001536 putative dimerization interface [polypeptide binding]; other site 460265001537 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 460265001538 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 460265001539 FMN binding site [chemical binding]; other site 460265001540 substrate binding site [chemical binding]; other site 460265001541 putative catalytic residue [active] 460265001542 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 460265001543 Protein of unknown function, DUF485; Region: DUF485; pfam04341 460265001544 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 460265001545 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 460265001546 Na binding site [ion binding]; other site 460265001547 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 460265001548 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 460265001549 FMN binding site [chemical binding]; other site 460265001550 substrate binding site [chemical binding]; other site 460265001551 putative catalytic residue [active] 460265001552 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 460265001553 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 460265001554 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 460265001555 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 460265001556 Na binding site [ion binding]; other site 460265001557 Protein of unknown function, DUF485; Region: DUF485; pfam04341 460265001558 Predicted amidohydrolase [General function prediction only]; Region: COG0388 460265001559 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 460265001560 putative active site [active] 460265001561 catalytic triad [active] 460265001562 putative dimer interface [polypeptide binding]; other site 460265001563 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265001564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265001565 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265001566 dimerization interface [polypeptide binding]; other site 460265001567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265001568 putative substrate translocation pore; other site 460265001569 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 460265001570 Moco binding site; other site 460265001571 metal coordination site [ion binding]; other site 460265001572 DDE domain; Region: DDE_Tnp_IS240; pfam13610 460265001573 Integrase core domain; Region: rve; pfam00665 460265001574 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 460265001575 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 460265001576 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265001577 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265001578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265001579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265001580 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 460265001581 dimer interface [polypeptide binding]; other site 460265001582 active site 460265001583 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 460265001584 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 460265001585 trimer interface [polypeptide binding]; other site 460265001586 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 460265001587 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 460265001588 trimer interface [polypeptide binding]; other site 460265001589 YadA-like C-terminal region; Region: YadA; pfam03895 460265001590 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 460265001591 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265001592 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265001593 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265001594 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265001595 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265001596 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 460265001597 tellurite resistance protein terB; Region: terB; cd07176 460265001598 putative metal binding site [ion binding]; other site 460265001599 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 460265001600 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 460265001601 ATP binding site [chemical binding]; other site 460265001602 putative Mg++ binding site [ion binding]; other site 460265001603 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 460265001604 nucleotide binding region [chemical binding]; other site 460265001605 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 460265001606 active site 460265001607 Int/Topo IB signature motif; other site 460265001608 DNA binding site [nucleotide binding] 460265001609 CitB domain protein; Region: CitB; TIGR02484 460265001610 tricarballylate dehydrogenase; Validated; Region: PRK08274 460265001611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 460265001612 Predicted oxidoreductase [General function prediction only]; Region: COG3573 460265001613 Transcriptional regulators [Transcription]; Region: FadR; COG2186 460265001614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265001615 DNA-binding site [nucleotide binding]; DNA binding site 460265001616 FCD domain; Region: FCD; pfam07729 460265001617 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 460265001618 Predicted oxidoreductase [General function prediction only]; Region: COG3573 460265001619 short chain dehydrogenase; Provisional; Region: PRK12937 460265001620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265001621 NAD(P) binding site [chemical binding]; other site 460265001622 active site 460265001623 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 460265001624 extended (e) SDRs; Region: SDR_e; cd08946 460265001625 NAD(P) binding site [chemical binding]; other site 460265001626 active site 460265001627 substrate binding site [chemical binding]; other site 460265001628 Cupin domain; Region: Cupin_2; pfam07883 460265001629 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 460265001630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265001631 NAD(P) binding site [chemical binding]; other site 460265001632 active site 460265001633 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 460265001634 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 460265001635 AP (apurinic/apyrimidinic) site pocket; other site 460265001636 DNA interaction; other site 460265001637 Metal-binding active site; metal-binding site 460265001638 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265001639 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265001640 TM-ABC transporter signature motif; other site 460265001641 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265001642 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265001643 Walker A/P-loop; other site 460265001644 ATP binding site [chemical binding]; other site 460265001645 Q-loop/lid; other site 460265001646 ABC transporter signature motif; other site 460265001647 Walker B; other site 460265001648 D-loop; other site 460265001649 H-loop/switch region; other site 460265001650 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265001651 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265001652 Walker A/P-loop; other site 460265001653 ATP binding site [chemical binding]; other site 460265001654 Q-loop/lid; other site 460265001655 ABC transporter signature motif; other site 460265001656 Walker B; other site 460265001657 D-loop; other site 460265001658 H-loop/switch region; other site 460265001659 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 460265001660 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265001661 TM-ABC transporter signature motif; other site 460265001662 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265001663 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265001664 putative ligand binding site [chemical binding]; other site 460265001665 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 460265001666 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 460265001667 PYR/PP interface [polypeptide binding]; other site 460265001668 dimer interface [polypeptide binding]; other site 460265001669 TPP binding site [chemical binding]; other site 460265001670 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 460265001671 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 460265001672 TPP-binding site [chemical binding]; other site 460265001673 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 460265001674 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 460265001675 NAD(P) binding site [chemical binding]; other site 460265001676 catalytic residues [active] 460265001677 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265001678 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265001679 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 460265001680 putative dimerization interface [polypeptide binding]; other site 460265001681 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265001682 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265001683 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265001684 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265001685 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 460265001686 EamA-like transporter family; Region: EamA; pfam00892 460265001687 Winged helix-turn helix; Region: HTH_29; pfam13551 460265001688 Homeodomain-like domain; Region: HTH_23; cl17451 460265001689 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 460265001690 aromatic arch; other site 460265001691 DCoH dimer interaction site [polypeptide binding]; other site 460265001692 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 460265001693 DCoH tetramer interaction site [polypeptide binding]; other site 460265001694 substrate binding site [chemical binding]; other site 460265001695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265001696 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 460265001697 dimerization interface [polypeptide binding]; other site 460265001698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265001699 dimer interface [polypeptide binding]; other site 460265001700 phosphorylation site [posttranslational modification] 460265001701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265001702 ATP binding site [chemical binding]; other site 460265001703 G-X-G motif; other site 460265001704 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 460265001705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265001706 active site 460265001707 phosphorylation site [posttranslational modification] 460265001708 intermolecular recognition site; other site 460265001709 dimerization interface [polypeptide binding]; other site 460265001710 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265001711 DNA binding site [nucleotide binding] 460265001712 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 460265001713 dimer interface [polypeptide binding]; other site 460265001714 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 460265001715 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 460265001716 conserved cys residue [active] 460265001717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265001718 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 460265001719 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 460265001720 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 460265001721 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 460265001722 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 460265001723 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 460265001724 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 460265001725 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 460265001726 dimer interface [polypeptide binding]; other site 460265001727 active site 460265001728 glycine-pyridoxal phosphate binding site [chemical binding]; other site 460265001729 folate binding site [chemical binding]; other site 460265001730 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 460265001731 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 460265001732 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 460265001733 Winged helix-turn helix; Region: HTH_29; pfam13551 460265001734 Uncharacterized conserved protein [Function unknown]; Region: COG5649 460265001735 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 460265001736 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265001737 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 460265001738 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265001739 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 460265001740 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265001741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265001742 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265001743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265001744 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265001745 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265001746 RES domain; Region: RES; pfam08808 460265001747 DNA topoisomerase 2; Provisional; Region: PLN03237 460265001748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 460265001749 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 460265001750 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 460265001751 Transposase; Region: DDE_Tnp_ISL3; pfam01610 460265001752 Transposase; Region: DDE_Tnp_ISL3; pfam01610 460265001753 Homeodomain-like domain; Region: HTH_23; pfam13384 460265001754 Winged helix-turn helix; Region: HTH_29; pfam13551 460265001755 Homeodomain-like domain; Region: HTH_32; pfam13565 460265001756 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265001757 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 460265001758 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 460265001759 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 460265001760 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 460265001761 FAD binding domain; Region: FAD_binding_4; pfam01565 460265001762 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 460265001763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265001764 D-galactonate transporter; Region: 2A0114; TIGR00893 460265001765 putative substrate translocation pore; other site 460265001766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265001767 hypothetical protein; Validated; Region: PRK06201 460265001768 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 460265001769 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 460265001770 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 460265001771 active site 460265001772 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 460265001773 DctM-like transporters; Region: DctM; pfam06808 460265001774 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 460265001775 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 460265001776 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 460265001777 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265001778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265001779 DNA-binding site [nucleotide binding]; DNA binding site 460265001780 FCD domain; Region: FCD; pfam07729 460265001781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 460265001782 Integrase core domain; Region: rve; pfam00665 460265001783 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 460265001784 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 460265001785 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 460265001786 catalytic nucleophile [active] 460265001787 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 460265001788 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265001789 substrate binding pocket [chemical binding]; other site 460265001790 membrane-bound complex binding site; other site 460265001791 hinge residues; other site 460265001792 benzoate transport; Region: 2A0115; TIGR00895 460265001793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265001794 putative substrate translocation pore; other site 460265001795 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 460265001796 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 460265001797 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 460265001798 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 460265001799 active site 460265001800 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265001801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265001802 DNA-binding site [nucleotide binding]; DNA binding site 460265001803 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 460265001804 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 460265001805 shikimate transporter; Provisional; Region: PRK09952 460265001806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265001807 putative substrate translocation pore; other site 460265001808 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 460265001809 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 460265001810 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 460265001811 shikimate binding site; other site 460265001812 NAD(P) binding site [chemical binding]; other site 460265001813 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 460265001814 nucleoside/Zn binding site; other site 460265001815 dimer interface [polypeptide binding]; other site 460265001816 catalytic motif [active] 460265001817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 460265001818 Transposase domain (DUF772); Region: DUF772; pfam05598 460265001819 Dehydratase family; Region: ILVD_EDD; cl00340 460265001820 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 460265001821 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 460265001822 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 460265001823 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 460265001824 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 460265001825 Amidohydrolase; Region: Amidohydro_2; pfam04909 460265001826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265001827 D-galactonate transporter; Region: 2A0114; TIGR00893 460265001828 putative substrate translocation pore; other site 460265001829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265001830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265001831 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 460265001832 putative dimerization interface [polypeptide binding]; other site 460265001833 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 460265001834 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 460265001835 Cytochrome c; Region: Cytochrom_C; cl11414 460265001836 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 460265001837 sulfite oxidase; Provisional; Region: PLN00177 460265001838 Moco binding site; other site 460265001839 metal coordination site [ion binding]; other site 460265001840 Predicted membrane protein [Function unknown]; Region: COG2855 460265001841 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 460265001842 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 460265001843 Amidohydrolase; Region: Amidohydro_2; pfam04909 460265001844 Fumarase C-terminus; Region: Fumerase_C; cl00795 460265001845 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 460265001846 L-aspartate oxidase; Provisional; Region: PRK06175 460265001847 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 460265001848 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 460265001849 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 460265001850 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 460265001851 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 460265001852 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265001853 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265001854 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 460265001855 putative dimerization interface [polypeptide binding]; other site 460265001856 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265001857 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265001858 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 460265001859 putative dimerization interface [polypeptide binding]; other site 460265001860 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 460265001861 Moco binding site; other site 460265001862 metal coordination site [ion binding]; other site 460265001863 dimerization interface [polypeptide binding]; other site 460265001864 Cytochrome c; Region: Cytochrom_C; pfam00034 460265001865 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 460265001866 dimer interface [polypeptide binding]; other site 460265001867 NADPH bind site [chemical binding]; other site 460265001868 FMN binding site [chemical binding]; other site 460265001869 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 460265001870 active site 2 [active] 460265001871 active site 1 [active] 460265001872 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 460265001873 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 460265001874 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 460265001875 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 460265001876 dimer interface [polypeptide binding]; other site 460265001877 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 460265001878 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 460265001879 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 460265001880 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 460265001881 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265001882 Winged helix-turn helix; Region: HTH_29; pfam13551 460265001883 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265001884 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265001885 catalytic residue [active] 460265001886 Sporulation related domain; Region: SPOR; cl10051 460265001887 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265001888 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265001889 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265001890 Replication protein C N-terminal domain; Region: RP-C; pfam03428 460265001891 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 460265001892 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 460265001893 MerR family regulatory protein; Region: MerR; pfam00376 460265001894 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 460265001895 P-loop; other site 460265001896 Magnesium ion binding site [ion binding]; other site 460265001897 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 460265001898 Magnesium ion binding site [ion binding]; other site 460265001899 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 460265001900 ParB-like nuclease domain; Region: ParBc; pfam02195 460265001901 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 460265001902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 460265001903 formyl-coenzyme A transferase; Provisional; Region: PRK05398 460265001904 CoA-transferase family III; Region: CoA_transf_3; pfam02515 460265001905 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 460265001906 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 460265001907 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 460265001908 CoA binding domain; Region: CoA_binding_2; pfam13380 460265001909 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 460265001910 putative phosphoketolase; Provisional; Region: PRK05261 460265001911 XFP N-terminal domain; Region: XFP_N; pfam09364 460265001912 XFP C-terminal domain; Region: XFP_C; pfam09363 460265001913 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 460265001914 Ligand Binding Site [chemical binding]; other site 460265001915 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 460265001916 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 460265001917 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 460265001918 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 460265001919 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 460265001920 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 460265001921 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 460265001922 Soluble P-type ATPase [General function prediction only]; Region: COG4087 460265001923 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 460265001924 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 460265001925 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 460265001926 motif II; other site 460265001927 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 460265001928 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 460265001929 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 460265001930 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 460265001931 SPW repeat; Region: SPW; pfam03779 460265001932 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 460265001933 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 460265001934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265001935 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265001936 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265001937 transcriptional regulator; Provisional; Region: PRK10632 460265001938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265001939 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 460265001940 putative effector binding pocket; other site 460265001941 dimerization interface [polypeptide binding]; other site 460265001942 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 460265001943 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 460265001944 NADH(P)-binding; Region: NAD_binding_10; pfam13460 460265001945 NAD binding site [chemical binding]; other site 460265001946 substrate binding site [chemical binding]; other site 460265001947 putative active site [active] 460265001948 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 460265001949 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 460265001950 Recombinase; Region: Recombinase; pfam07508 460265001951 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 460265001952 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265001953 Domain of unknown function (DUF4313); Region: DUF4313; pfam14190 460265001954 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265001955 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 460265001956 Methyltransferase domain; Region: Methyltransf_23; pfam13489 460265001957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265001958 S-adenosylmethionine binding site [chemical binding]; other site 460265001959 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265001960 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265001961 ligand binding site [chemical binding]; other site 460265001962 flexible hinge region; other site 460265001963 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 460265001964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 460265001965 phosphorylation site [posttranslational modification] 460265001966 intermolecular recognition site; other site 460265001967 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 460265001968 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 460265001969 P-loop; other site 460265001970 Magnesium ion binding site [ion binding]; other site 460265001971 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 460265001972 hypothetical protein; Provisional; Region: PRK14709 460265001973 D5 N terminal like; Region: D5_N; smart00885 460265001974 Phage terminase, small subunit; Region: Terminase_4; cl01525 460265001975 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265001976 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265001977 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265001978 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265001979 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 460265001980 active site 460265001981 catalytic triad [active] 460265001982 Uncharacterized conserved protein [Function unknown]; Region: COG5649 460265001983 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 460265001984 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265001985 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 460265001986 TIR domain; Region: TIR_2; pfam13676 460265001987 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 460265001988 binding surface 460265001989 TPR motif; other site 460265001990 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 460265001991 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 460265001992 catalytic residues [active] 460265001993 catalytic nucleophile [active] 460265001994 DnaA N-terminal domain; Region: DnaA_N; pfam11638 460265001995 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 460265001996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265001997 Walker A motif; other site 460265001998 ATP binding site [chemical binding]; other site 460265001999 Walker B motif; other site 460265002000 arginine finger; other site 460265002001 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 460265002002 DnaA box-binding interface [nucleotide binding]; other site 460265002003 DNA polymerase III subunit beta; Validated; Region: PRK05643 460265002004 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 460265002005 putative DNA binding surface [nucleotide binding]; other site 460265002006 dimer interface [polypeptide binding]; other site 460265002007 beta-clamp/clamp loader binding surface; other site 460265002008 beta-clamp/translesion DNA polymerase binding surface; other site 460265002009 recombination protein F; Reviewed; Region: recF; PRK00064 460265002010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265002011 Walker A/P-loop; other site 460265002012 ATP binding site [chemical binding]; other site 460265002013 Q-loop/lid; other site 460265002014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265002015 ABC transporter signature motif; other site 460265002016 Walker B; other site 460265002017 D-loop; other site 460265002018 H-loop/switch region; other site 460265002019 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 460265002020 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 460265002021 ATP binding site [chemical binding]; other site 460265002022 putative Mg++ binding site [ion binding]; other site 460265002023 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 460265002024 nucleotide binding region [chemical binding]; other site 460265002025 ATP-binding site [chemical binding]; other site 460265002026 RQC domain; Region: RQC; pfam09382 460265002027 HRDC domain; Region: HRDC; pfam00570 460265002028 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 460265002029 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 460265002030 N-terminal plug; other site 460265002031 ligand-binding site [chemical binding]; other site 460265002032 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 460265002033 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 460265002034 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 460265002035 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 460265002036 dimerization interface [polypeptide binding]; other site 460265002037 ATP binding site [chemical binding]; other site 460265002038 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 460265002039 dimerization interface [polypeptide binding]; other site 460265002040 ATP binding site [chemical binding]; other site 460265002041 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 460265002042 Domain of unknown function DUF29; Region: DUF29; pfam01724 460265002043 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 460265002044 putative GSH binding site [chemical binding]; other site 460265002045 catalytic residues [active] 460265002046 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 460265002047 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 460265002048 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 460265002049 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 460265002050 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 460265002051 active site 460265002052 Zn binding site [ion binding]; other site 460265002053 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 460265002054 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 460265002055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 460265002056 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 460265002057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 460265002058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 460265002059 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 460265002060 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 460265002061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265002062 active site 460265002063 phosphorylation site [posttranslational modification] 460265002064 intermolecular recognition site; other site 460265002065 dimerization interface [polypeptide binding]; other site 460265002066 Domain of unknown function (DUF4206); Region: DUF4206; pfam13901 460265002067 hypothetical protein; Provisional; Region: PRK14679 460265002068 Predicted methyltransferases [General function prediction only]; Region: COG0313 460265002069 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 460265002070 putative SAM binding site [chemical binding]; other site 460265002071 putative homodimer interface [polypeptide binding]; other site 460265002072 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 460265002073 putative ligand binding site [chemical binding]; other site 460265002074 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 460265002075 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265002076 FeS/SAM binding site; other site 460265002077 HemN C-terminal domain; Region: HemN_C; pfam06969 460265002078 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 460265002079 Caspase domain; Region: Peptidase_C14; pfam00656 460265002080 Bacterial SH3 domain; Region: SH3_3; pfam08239 460265002081 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 460265002082 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 460265002083 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 460265002084 Zn2+ binding site [ion binding]; other site 460265002085 Mg2+ binding site [ion binding]; other site 460265002086 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 460265002087 synthetase active site [active] 460265002088 NTP binding site [chemical binding]; other site 460265002089 metal binding site [ion binding]; metal-binding site 460265002090 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 460265002091 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 460265002092 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 460265002093 active site 460265002094 Uncharacterized conserved protein [Function unknown]; Region: COG1432 460265002095 LabA_like proteins; Region: LabA; cd10911 460265002096 putative metal binding site [ion binding]; other site 460265002097 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 460265002098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265002099 NAD(P) binding site [chemical binding]; other site 460265002100 active site 460265002101 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 460265002102 Mg++ binding site [ion binding]; other site 460265002103 putative catalytic motif [active] 460265002104 putative substrate binding site [chemical binding]; other site 460265002105 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, MeaA-like subfamily; contains various methylmalonyl coenzyme A (CoA) mutase (MCM)-like proteins similar to the Streptomyces cinnamonensis MeaA, Methylobacterium extorquens MeaA...; Region: MM_CoA_mutase_MeaA; cd03681 460265002106 putative active site [active] 460265002107 putative substrate binding site [chemical binding]; other site 460265002108 putative coenzyme B12 binding site [chemical binding]; other site 460265002109 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 460265002110 B12 binding site [chemical binding]; other site 460265002111 cobalt ligand [ion binding]; other site 460265002112 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 460265002113 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 460265002114 putative NAD(P) binding site [chemical binding]; other site 460265002115 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 460265002116 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 460265002117 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 460265002118 substrate binding site [chemical binding]; other site 460265002119 Transglycosylase SLT domain; Region: SLT_2; pfam13406 460265002120 murein hydrolase B; Provisional; Region: PRK10760; cl17906 460265002121 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 460265002122 cyanate transporter; Region: CynX; TIGR00896 460265002123 heat shock protein 90; Provisional; Region: PRK05218 460265002124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265002125 ATP binding site [chemical binding]; other site 460265002126 G-X-G motif; other site 460265002127 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 460265002128 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 460265002129 active site 460265002130 catalytic site [active] 460265002131 substrate binding site [chemical binding]; other site 460265002132 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 460265002133 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265002134 ligand binding site [chemical binding]; other site 460265002135 flexible hinge region; other site 460265002136 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 460265002137 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 460265002138 metal binding triad; other site 460265002139 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 460265002140 putative active site [active] 460265002141 putative catalytic site [active] 460265002142 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 460265002143 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 460265002144 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 460265002145 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265002146 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 460265002147 acyl-activating enzyme (AAE) consensus motif; other site 460265002148 acyl-activating enzyme (AAE) consensus motif; other site 460265002149 putative AMP binding site [chemical binding]; other site 460265002150 putative active site [active] 460265002151 putative CoA binding site [chemical binding]; other site 460265002152 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 460265002153 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 460265002154 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 460265002155 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 460265002156 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 460265002157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265002158 catalytic residue [active] 460265002159 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 460265002160 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 460265002161 glutamine binding [chemical binding]; other site 460265002162 catalytic triad [active] 460265002163 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 460265002164 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 460265002165 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 460265002166 NMT1-like family; Region: NMT1_2; pfam13379 460265002167 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 460265002168 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 460265002169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 460265002170 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 460265002171 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 460265002172 Walker A/P-loop; other site 460265002173 ATP binding site [chemical binding]; other site 460265002174 Q-loop/lid; other site 460265002175 ABC transporter signature motif; other site 460265002176 Walker B; other site 460265002177 D-loop; other site 460265002178 H-loop/switch region; other site 460265002179 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 460265002180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265002181 active site 460265002182 phosphorylation site [posttranslational modification] 460265002183 intermolecular recognition site; other site 460265002184 dimerization interface [polypeptide binding]; other site 460265002185 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265002186 DNA binding site [nucleotide binding] 460265002187 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 460265002188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265002189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265002190 dimer interface [polypeptide binding]; other site 460265002191 phosphorylation site [posttranslational modification] 460265002192 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 460265002193 ATP binding site [chemical binding]; other site 460265002194 Mg2+ binding site [ion binding]; other site 460265002195 G-X-G motif; other site 460265002196 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 460265002197 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 460265002198 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 460265002199 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 460265002200 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 460265002201 putative active site [active] 460265002202 metal binding site [ion binding]; metal-binding site 460265002203 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265002204 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_10; cd06345 460265002205 putative ligand binding site [chemical binding]; other site 460265002206 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265002207 TM-ABC transporter signature motif; other site 460265002208 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265002209 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265002210 TM-ABC transporter signature motif; other site 460265002211 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265002212 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265002213 Walker A/P-loop; other site 460265002214 ATP binding site [chemical binding]; other site 460265002215 Q-loop/lid; other site 460265002216 ABC transporter signature motif; other site 460265002217 Walker B; other site 460265002218 D-loop; other site 460265002219 H-loop/switch region; other site 460265002220 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265002221 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265002222 Walker A/P-loop; other site 460265002223 ATP binding site [chemical binding]; other site 460265002224 Q-loop/lid; other site 460265002225 ABC transporter signature motif; other site 460265002226 Walker B; other site 460265002227 D-loop; other site 460265002228 H-loop/switch region; other site 460265002229 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265002230 hypothetical protein; Provisional; Region: PRK05208 460265002231 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 460265002232 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 460265002233 trimer interface [polypeptide binding]; other site 460265002234 active site 460265002235 substrate binding site [chemical binding]; other site 460265002236 CoA binding site [chemical binding]; other site 460265002237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265002238 Response regulator receiver domain; Region: Response_reg; pfam00072 460265002239 active site 460265002240 phosphorylation site [posttranslational modification] 460265002241 intermolecular recognition site; other site 460265002242 dimerization interface [polypeptide binding]; other site 460265002243 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 460265002244 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 460265002245 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 460265002246 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 460265002247 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 460265002248 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 460265002249 cyclase homology domain; Region: CHD; cd07302 460265002250 nucleotidyl binding site; other site 460265002251 metal binding site [ion binding]; metal-binding site 460265002252 dimer interface [polypeptide binding]; other site 460265002253 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 460265002254 active site 460265002255 catalytic triad [active] 460265002256 oxyanion hole [active] 460265002257 Phasin protein; Region: Phasin_2; pfam09361 460265002258 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 460265002259 CsbD-like; Region: CsbD; pfam05532 460265002260 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 460265002261 cyclase homology domain; Region: CHD; cd07302 460265002262 nucleotidyl binding site; other site 460265002263 metal binding site [ion binding]; metal-binding site 460265002264 dimer interface [polypeptide binding]; other site 460265002265 Predicted integral membrane protein [Function unknown]; Region: COG5616 460265002266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265002267 TPR motif; other site 460265002268 binding surface 460265002269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265002270 TPR motif; other site 460265002271 binding surface 460265002272 TPR repeat; Region: TPR_11; pfam13414 460265002273 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 460265002274 cyclase homology domain; Region: CHD; cd07302 460265002275 nucleotidyl binding site; other site 460265002276 metal binding site [ion binding]; metal-binding site 460265002277 dimer interface [polypeptide binding]; other site 460265002278 Predicted integral membrane protein [Function unknown]; Region: COG5616 460265002279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265002280 binding surface 460265002281 TPR motif; other site 460265002282 TPR repeat; Region: TPR_11; pfam13414 460265002283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265002284 TPR motif; other site 460265002285 binding surface 460265002286 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 460265002287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265002288 Walker A/P-loop; other site 460265002289 ATP binding site [chemical binding]; other site 460265002290 Q-loop/lid; other site 460265002291 ABC transporter signature motif; other site 460265002292 Walker B; other site 460265002293 D-loop; other site 460265002294 H-loop/switch region; other site 460265002295 TOBE domain; Region: TOBE_2; pfam08402 460265002296 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 460265002297 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 460265002298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265002299 dimer interface [polypeptide binding]; other site 460265002300 conserved gate region; other site 460265002301 putative PBP binding loops; other site 460265002302 ABC-ATPase subunit interface; other site 460265002303 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 460265002304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265002305 dimer interface [polypeptide binding]; other site 460265002306 conserved gate region; other site 460265002307 ABC-ATPase subunit interface; other site 460265002308 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 460265002309 classical (c) SDRs; Region: SDR_c; cd05233 460265002310 NAD(P) binding site [chemical binding]; other site 460265002311 active site 460265002312 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 460265002313 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 460265002314 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 460265002315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265002316 S-adenosylmethionine binding site [chemical binding]; other site 460265002317 aspartate kinase; Reviewed; Region: PRK06635 460265002318 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 460265002319 putative nucleotide binding site [chemical binding]; other site 460265002320 putative catalytic residues [active] 460265002321 putative Mg ion binding site [ion binding]; other site 460265002322 putative aspartate binding site [chemical binding]; other site 460265002323 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 460265002324 putative allosteric regulatory site; other site 460265002325 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 460265002326 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 460265002327 GAF domain; Region: GAF; pfam01590 460265002328 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 460265002329 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 460265002330 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 460265002331 peptide chain release factor 1; Validated; Region: prfA; PRK00591 460265002332 This domain is found in peptide chain release factors; Region: PCRF; smart00937 460265002333 RF-1 domain; Region: RF-1; pfam00472 460265002334 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 460265002335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265002336 S-adenosylmethionine binding site [chemical binding]; other site 460265002337 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 460265002338 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 460265002339 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265002340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265002341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265002342 metabolite-proton symporter; Region: 2A0106; TIGR00883 460265002343 putative substrate translocation pore; other site 460265002344 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 460265002345 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 460265002346 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 460265002347 shikimate binding site; other site 460265002348 NAD(P) binding site [chemical binding]; other site 460265002349 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 460265002350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265002351 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 460265002352 putative dimerization interface [polypeptide binding]; other site 460265002353 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 460265002354 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 460265002355 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 460265002356 shikimate binding site; other site 460265002357 NAD(P) binding site [chemical binding]; other site 460265002358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265002359 metabolite-proton symporter; Region: 2A0106; TIGR00883 460265002360 putative substrate translocation pore; other site 460265002361 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 460265002362 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 460265002363 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 460265002364 dimer interface [polypeptide binding]; other site 460265002365 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 460265002366 active site 460265002367 Fe binding site [ion binding]; other site 460265002368 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 460265002369 Dehydroquinase class II; Region: DHquinase_II; pfam01220 460265002370 trimer interface [polypeptide binding]; other site 460265002371 active site 460265002372 dimer interface [polypeptide binding]; other site 460265002373 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265002374 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 460265002375 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 460265002376 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 460265002377 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265002378 sequence-specific DNA binding site [nucleotide binding]; other site 460265002379 salt bridge; other site 460265002380 Cupin domain; Region: Cupin_2; pfam07883 460265002381 Homeodomain-like domain; Region: HTH_23; cl17451 460265002382 Winged helix-turn helix; Region: HTH_29; pfam13551 460265002383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 460265002384 Integrase core domain; Region: rve; pfam00665 460265002385 Integrase core domain; Region: rve_3; pfam13683 460265002386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265002387 dimer interface [polypeptide binding]; other site 460265002388 phosphorylation site [posttranslational modification] 460265002389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265002390 ATP binding site [chemical binding]; other site 460265002391 Mg2+ binding site [ion binding]; other site 460265002392 G-X-G motif; other site 460265002393 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 460265002394 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 460265002395 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 460265002396 catalytic core [active] 460265002397 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 460265002398 active site 460265002399 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 460265002400 DOMON-like domain of an uncharacterized protein family; Region: DOMON_like_cytochrome; cd09625 460265002401 putative ligand binding site [chemical binding]; other site 460265002402 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265002403 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 460265002404 catalytic loop [active] 460265002405 iron binding site [ion binding]; other site 460265002406 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 460265002407 FAD binding pocket [chemical binding]; other site 460265002408 FAD binding motif [chemical binding]; other site 460265002409 phosphate binding motif [ion binding]; other site 460265002410 beta-alpha-beta structure motif; other site 460265002411 NAD binding pocket [chemical binding]; other site 460265002412 YcfA-like protein; Region: YcfA; pfam07927 460265002413 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 460265002414 PBP superfamily domain; Region: PBP_like_2; cl17296 460265002415 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 460265002416 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 460265002417 putative oligomer interface [polypeptide binding]; other site 460265002418 putative active site [active] 460265002419 metal binding site [ion binding]; metal-binding site 460265002420 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 460265002421 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 460265002422 ATP-grasp domain; Region: ATP-grasp_4; cl17255 460265002423 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 460265002424 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 460265002425 active site 460265002426 dimer interface [polypeptide binding]; other site 460265002427 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 460265002428 Ligand Binding Site [chemical binding]; other site 460265002429 Molecular Tunnel; other site 460265002430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265002431 active site 460265002432 phosphorylation site [posttranslational modification] 460265002433 intermolecular recognition site; other site 460265002434 dimerization interface [polypeptide binding]; other site 460265002435 PAS fold; Region: PAS_7; pfam12860 460265002436 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 460265002437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265002438 putative active site [active] 460265002439 heme pocket [chemical binding]; other site 460265002440 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265002441 putative active site [active] 460265002442 heme pocket [chemical binding]; other site 460265002443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265002444 dimer interface [polypeptide binding]; other site 460265002445 phosphorylation site [posttranslational modification] 460265002446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265002447 ATP binding site [chemical binding]; other site 460265002448 Mg2+ binding site [ion binding]; other site 460265002449 G-X-G motif; other site 460265002450 Response regulator receiver domain; Region: Response_reg; pfam00072 460265002451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265002452 active site 460265002453 phosphorylation site [posttranslational modification] 460265002454 intermolecular recognition site; other site 460265002455 dimerization interface [polypeptide binding]; other site 460265002456 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 460265002457 putative binding surface; other site 460265002458 active site 460265002459 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 460265002460 enoyl-CoA hydratase; Validated; Region: PRK08139 460265002461 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265002462 substrate binding site [chemical binding]; other site 460265002463 oxyanion hole (OAH) forming residues; other site 460265002464 trimer interface [polypeptide binding]; other site 460265002465 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 460265002466 CoenzymeA binding site [chemical binding]; other site 460265002467 subunit interaction site [polypeptide binding]; other site 460265002468 PHB binding site; other site 460265002469 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 460265002470 23S rRNA interface [nucleotide binding]; other site 460265002471 L3 interface [polypeptide binding]; other site 460265002472 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 460265002473 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 460265002474 active site 460265002475 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 460265002476 putative deacylase active site [active] 460265002477 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 460265002478 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 460265002479 tetramer interface [polypeptide binding]; other site 460265002480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265002481 catalytic residue [active] 460265002482 enoyl-CoA hydratase; Provisional; Region: PRK05862 460265002483 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265002484 substrate binding site [chemical binding]; other site 460265002485 oxyanion hole (OAH) forming residues; other site 460265002486 trimer interface [polypeptide binding]; other site 460265002487 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 460265002488 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 460265002489 active site 460265002490 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 460265002491 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 460265002492 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 460265002493 putative dimer interface [polypeptide binding]; other site 460265002494 N-terminal domain interface [polypeptide binding]; other site 460265002495 putative substrate binding pocket (H-site) [chemical binding]; other site 460265002496 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 460265002497 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 460265002498 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 460265002499 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 460265002500 Cytochrome P450; Region: p450; cl12078 460265002501 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265002502 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265002503 ligand binding site [chemical binding]; other site 460265002504 flexible hinge region; other site 460265002505 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 460265002506 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 460265002507 nucleophile elbow; other site 460265002508 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 460265002509 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 460265002510 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 460265002511 cyclase homology domain; Region: CHD; cd07302 460265002512 nucleotidyl binding site; other site 460265002513 metal binding site [ion binding]; metal-binding site 460265002514 dimer interface [polypeptide binding]; other site 460265002515 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 460265002516 Protein of unknown function, DUF482; Region: DUF482; pfam04339 460265002517 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 460265002518 quinolinate synthetase; Provisional; Region: PRK09375 460265002519 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 460265002520 L-aspartate oxidase; Provisional; Region: PRK06175 460265002521 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 460265002522 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 460265002523 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 460265002524 dimerization interface [polypeptide binding]; other site 460265002525 active site 460265002526 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 460265002527 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 460265002528 aconitate hydratase; Validated; Region: PRK09277 460265002529 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 460265002530 substrate binding site [chemical binding]; other site 460265002531 ligand binding site [chemical binding]; other site 460265002532 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 460265002533 substrate binding site [chemical binding]; other site 460265002534 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 460265002535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265002536 Walker A/P-loop; other site 460265002537 ATP binding site [chemical binding]; other site 460265002538 Q-loop/lid; other site 460265002539 ABC transporter signature motif; other site 460265002540 Walker B; other site 460265002541 D-loop; other site 460265002542 H-loop/switch region; other site 460265002543 heme exporter protein CcmB; Region: ccmB; TIGR01190 460265002544 heme exporter protein CcmC; Region: ccmC; TIGR01191 460265002545 Heme exporter protein D (CcmD); Region: CcmD; pfam04995 460265002546 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 460265002547 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 460265002548 catalytic residues [active] 460265002549 central insert; other site 460265002550 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265002551 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265002552 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265002553 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 460265002554 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 460265002555 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 460265002556 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 460265002557 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 460265002558 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 460265002559 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265002560 FeS/SAM binding site; other site 460265002561 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 460265002562 CoenzymeA binding site [chemical binding]; other site 460265002563 subunit interaction site [polypeptide binding]; other site 460265002564 PHB binding site; other site 460265002565 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 460265002566 catalytic core [active] 460265002567 malate synthase G; Provisional; Region: PRK02999 460265002568 active site 460265002569 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 460265002570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 460265002571 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 460265002572 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 460265002573 Phospholipid methyltransferase; Region: PEMT; cl17370 460265002574 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 460265002575 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 460265002576 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 460265002577 Soluble P-type ATPase [General function prediction only]; Region: COG4087 460265002578 potassium-transporting ATPase subunit C; Provisional; Region: PRK13999 460265002579 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 460265002580 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 460265002581 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 460265002582 Ligand Binding Site [chemical binding]; other site 460265002583 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 460265002584 GAF domain; Region: GAF_3; pfam13492 460265002585 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265002586 dimer interface [polypeptide binding]; other site 460265002587 phosphorylation site [posttranslational modification] 460265002588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265002589 ATP binding site [chemical binding]; other site 460265002590 Mg2+ binding site [ion binding]; other site 460265002591 G-X-G motif; other site 460265002592 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 460265002593 active site 460265002594 phosphorylation site [posttranslational modification] 460265002595 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 460265002596 alpha-amylase; Region: PLN02361 460265002597 Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314 460265002598 active site 460265002599 Ca binding site [ion binding]; other site 460265002600 catalytic site [active] 460265002601 Dodecin; Region: Dodecin; pfam07311 460265002602 Transglycosylase; Region: Transgly; pfam00912 460265002603 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 460265002604 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 460265002605 Uncharacterized conserved protein [Function unknown]; Region: COG4850 460265002606 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 460265002607 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 460265002608 DHH family; Region: DHH; pfam01368 460265002609 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 460265002610 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 460265002611 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 460265002612 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 460265002613 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 460265002614 ligand binding site [chemical binding]; other site 460265002615 homodimer interface [polypeptide binding]; other site 460265002616 NAD(P) binding site [chemical binding]; other site 460265002617 trimer interface B [polypeptide binding]; other site 460265002618 trimer interface A [polypeptide binding]; other site 460265002619 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 460265002620 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 460265002621 ABC1 family; Region: ABC1; cl17513 460265002622 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 460265002623 putative homodimer interface [polypeptide binding]; other site 460265002624 putative homotetramer interface [polypeptide binding]; other site 460265002625 putative allosteric switch controlling residues; other site 460265002626 putative metal binding site [ion binding]; other site 460265002627 putative homodimer-homodimer interface [polypeptide binding]; other site 460265002628 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 460265002629 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 460265002630 active site 460265002631 Zn binding site [ion binding]; other site 460265002632 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 460265002633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265002634 active site 460265002635 phosphorylation site [posttranslational modification] 460265002636 intermolecular recognition site; other site 460265002637 dimerization interface [polypeptide binding]; other site 460265002638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265002639 Walker A motif; other site 460265002640 ATP binding site [chemical binding]; other site 460265002641 Walker B motif; other site 460265002642 arginine finger; other site 460265002643 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 460265002644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 460265002645 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 460265002646 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 460265002647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 460265002648 Peptidase M15; Region: Peptidase_M15_3; cl01194 460265002649 putative amidase; Provisional; Region: PRK06169 460265002650 Amidase; Region: Amidase; cl11426 460265002651 Protein of unknown function DUF82; Region: DUF82; pfam01927 460265002652 Uncharacterized conserved protein [Function unknown]; Region: COG1656 460265002653 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 460265002654 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 460265002655 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 460265002656 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 460265002657 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265002658 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265002659 Walker A/P-loop; other site 460265002660 ATP binding site [chemical binding]; other site 460265002661 Q-loop/lid; other site 460265002662 ABC transporter signature motif; other site 460265002663 Walker B; other site 460265002664 D-loop; other site 460265002665 H-loop/switch region; other site 460265002666 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265002667 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265002668 Walker A/P-loop; other site 460265002669 ATP binding site [chemical binding]; other site 460265002670 Q-loop/lid; other site 460265002671 ABC transporter signature motif; other site 460265002672 Walker B; other site 460265002673 D-loop; other site 460265002674 H-loop/switch region; other site 460265002675 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265002676 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265002677 TM-ABC transporter signature motif; other site 460265002678 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265002679 TM-ABC transporter signature motif; other site 460265002680 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265002681 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 460265002682 putative ligand binding site [chemical binding]; other site 460265002683 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 460265002684 Transcriptional regulator [Transcription]; Region: IclR; COG1414 460265002685 Bacterial transcriptional regulator; Region: IclR; pfam01614 460265002686 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 460265002687 classical (c) SDRs; Region: SDR_c; cd05233 460265002688 NAD(P) binding site [chemical binding]; other site 460265002689 active site 460265002690 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 460265002691 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 460265002692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265002693 sequence-specific DNA binding site [nucleotide binding]; other site 460265002694 salt bridge; other site 460265002695 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 460265002696 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 460265002697 putative active site [active] 460265002698 catalytic triad [active] 460265002699 putative dimer interface [polypeptide binding]; other site 460265002700 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 460265002701 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 460265002702 Transporter associated domain; Region: CorC_HlyC; smart01091 460265002703 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 460265002704 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 460265002705 PhoH-like protein; Region: PhoH; pfam02562 460265002706 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 460265002707 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 460265002708 TRAM domain; Region: TRAM; cl01282 460265002709 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 460265002710 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 460265002711 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 460265002712 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 460265002713 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 460265002714 NAD(P) binding site [chemical binding]; other site 460265002715 catalytic residues [active] 460265002716 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265002717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265002718 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265002719 endonuclease subunit; Provisional; Region: 46; PHA02562 460265002720 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 460265002721 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 460265002722 metal binding site [ion binding]; metal-binding site 460265002723 putative dimer interface [polypeptide binding]; other site 460265002724 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 460265002725 active site 460265002726 catalytic residues [active] 460265002727 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 460265002728 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 460265002729 active site 460265002730 DNA binding site [nucleotide binding] 460265002731 Int/Topo IB signature motif; other site 460265002732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265002733 S-adenosylmethionine binding site [chemical binding]; other site 460265002734 GTP cyclohydrolase; Provisional; Region: PRK08815 460265002735 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 460265002736 dimerization interface [polypeptide binding]; other site 460265002737 active site 460265002738 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 460265002739 RibD C-terminal domain; Region: RibD_C; pfam01872 460265002740 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 460265002741 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 460265002742 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 460265002743 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 460265002744 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265002745 catalytic loop [active] 460265002746 iron binding site [ion binding]; other site 460265002747 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 460265002748 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 460265002749 [4Fe-4S] binding site [ion binding]; other site 460265002750 molybdopterin cofactor binding site; other site 460265002751 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 460265002752 molybdopterin cofactor binding site; other site 460265002753 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 460265002754 putative dimer interface [polypeptide binding]; other site 460265002755 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 460265002756 SLBB domain; Region: SLBB; pfam10531 460265002757 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 460265002758 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 460265002759 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 460265002760 putative dimer interface [polypeptide binding]; other site 460265002761 [2Fe-2S] cluster binding site [ion binding]; other site 460265002762 Uncharacterized conserved protein [Function unknown]; Region: COG3791 460265002763 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265002764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265002765 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 460265002766 dimerization interface [polypeptide binding]; other site 460265002767 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 460265002768 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 460265002769 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 460265002770 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 460265002771 Subunit I/III interface [polypeptide binding]; other site 460265002772 D-pathway; other site 460265002773 Subunit I/VIIc interface [polypeptide binding]; other site 460265002774 Subunit I/IV interface [polypeptide binding]; other site 460265002775 Subunit I/II interface [polypeptide binding]; other site 460265002776 Low-spin heme (heme a) binding site [chemical binding]; other site 460265002777 Subunit I/VIIa interface [polypeptide binding]; other site 460265002778 Dimer interface; other site 460265002779 Subunit I/VIa interface [polypeptide binding]; other site 460265002780 Putative water exit pathway; other site 460265002781 Binuclear center (heme a3/CuB) [ion binding]; other site 460265002782 K-pathway; other site 460265002783 Subunit I/Vb interface [polypeptide binding]; other site 460265002784 Putative proton exit pathway; other site 460265002785 Subunit I/VIb interface; other site 460265002786 Subunit I/VIc interface [polypeptide binding]; other site 460265002787 Electron transfer pathway; other site 460265002788 Subunit I/VIIIb interface [polypeptide binding]; other site 460265002789 Subunit I/VIIb interface [polypeptide binding]; other site 460265002790 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 460265002791 UbiA prenyltransferase family; Region: UbiA; pfam01040 460265002792 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 460265002793 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 460265002794 Subunit III/VIIa interface [polypeptide binding]; other site 460265002795 Phospholipid binding site [chemical binding]; other site 460265002796 Subunit I/III interface [polypeptide binding]; other site 460265002797 Subunit III/VIb interface [polypeptide binding]; other site 460265002798 Subunit III/VIa interface; other site 460265002799 Subunit III/Vb interface [polypeptide binding]; other site 460265002800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 460265002801 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 460265002802 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 460265002803 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 460265002804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265002805 catalytic residue [active] 460265002806 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 460265002807 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 460265002808 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 460265002809 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 460265002810 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265002811 PAS fold; Region: PAS_3; pfam08447 460265002812 putative active site [active] 460265002813 heme pocket [chemical binding]; other site 460265002814 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 460265002815 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 460265002816 metal binding site [ion binding]; metal-binding site 460265002817 active site 460265002818 I-site; other site 460265002819 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 460265002820 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265002821 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265002822 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265002823 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 460265002824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265002825 active site 460265002826 phosphorylation site [posttranslational modification] 460265002827 intermolecular recognition site; other site 460265002828 dimerization interface [polypeptide binding]; other site 460265002829 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 460265002830 FAD binding pocket [chemical binding]; other site 460265002831 FAD binding motif [chemical binding]; other site 460265002832 phosphate binding motif [ion binding]; other site 460265002833 beta-alpha-beta structure motif; other site 460265002834 NAD binding pocket [chemical binding]; other site 460265002835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265002836 Walker A/P-loop; other site 460265002837 ATP binding site [chemical binding]; other site 460265002838 Q-loop/lid; other site 460265002839 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 460265002840 High-affinity nickel-transport protein; Region: NicO; cl00964 460265002841 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 460265002842 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 460265002843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265002844 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 460265002845 dimerization interface [polypeptide binding]; other site 460265002846 substrate binding pocket [chemical binding]; other site 460265002847 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 460265002848 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 460265002849 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 460265002850 Autoinducer binding domain; Region: Autoind_bind; pfam03472 460265002851 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265002852 DNA binding residues [nucleotide binding] 460265002853 dimerization interface [polypeptide binding]; other site 460265002854 Autoinducer synthetase; Region: Autoind_synth; cl17404 460265002855 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 460265002856 active site 460265002857 putative DNA-binding cleft [nucleotide binding]; other site 460265002858 dimer interface [polypeptide binding]; other site 460265002859 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 460265002860 ornithine decarboxylase; Provisional; Region: PRK13578 460265002861 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 460265002862 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 460265002863 catalytic residue [active] 460265002864 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 460265002865 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 460265002866 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 460265002867 dimer interface [polypeptide binding]; other site 460265002868 PYR/PP interface [polypeptide binding]; other site 460265002869 TPP binding site [chemical binding]; other site 460265002870 substrate binding site [chemical binding]; other site 460265002871 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 460265002872 TPP-binding site; other site 460265002873 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 460265002874 AMP-binding domain protein; Validated; Region: PRK08315 460265002875 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265002876 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 460265002877 acyl-activating enzyme (AAE) consensus motif; other site 460265002878 putative AMP binding site [chemical binding]; other site 460265002879 putative active site [active] 460265002880 putative CoA binding site [chemical binding]; other site 460265002881 isovaleryl-CoA dehydrogenase; Region: PLN02519 460265002882 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 460265002883 substrate binding site [chemical binding]; other site 460265002884 FAD binding site [chemical binding]; other site 460265002885 catalytic base [active] 460265002886 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 460265002887 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 460265002888 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 460265002889 ATP-grasp domain; Region: ATP-grasp_4; cl17255 460265002890 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 460265002891 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 460265002892 putative active site [active] 460265002893 putative catalytic site [active] 460265002894 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 460265002895 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 460265002896 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265002897 acyl-activating enzyme (AAE) consensus motif; other site 460265002898 active site 460265002899 AMP binding site [chemical binding]; other site 460265002900 CoA binding site [chemical binding]; other site 460265002901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265002902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265002903 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 460265002904 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265002905 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265002906 Walker A/P-loop; other site 460265002907 ATP binding site [chemical binding]; other site 460265002908 Q-loop/lid; other site 460265002909 ABC transporter signature motif; other site 460265002910 Walker B; other site 460265002911 D-loop; other site 460265002912 H-loop/switch region; other site 460265002913 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 460265002914 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265002915 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 460265002916 acyl-activating enzyme (AAE) consensus motif; other site 460265002917 putative AMP binding site [chemical binding]; other site 460265002918 putative active site [active] 460265002919 putative CoA binding site [chemical binding]; other site 460265002920 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 460265002921 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265002922 TM-ABC transporter signature motif; other site 460265002923 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265002924 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265002925 TM-ABC transporter signature motif; other site 460265002926 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265002927 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 460265002928 putative ligand binding site [chemical binding]; other site 460265002929 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265002930 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265002931 Walker A/P-loop; other site 460265002932 ATP binding site [chemical binding]; other site 460265002933 Q-loop/lid; other site 460265002934 ABC transporter signature motif; other site 460265002935 Walker B; other site 460265002936 D-loop; other site 460265002937 H-loop/switch region; other site 460265002938 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 460265002939 active site 460265002940 homotetramer interface [polypeptide binding]; other site 460265002941 homodimer interface [polypeptide binding]; other site 460265002942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265002943 putative substrate translocation pore; other site 460265002944 Major Facilitator Superfamily; Region: MFS_1; pfam07690 460265002945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265002946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265002947 Domain of unknown function (DUF366); Region: DUF366; cl00890 460265002948 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 460265002949 putative active site; other site 460265002950 putative triphosphate binding site [ion binding]; other site 460265002951 putative metal binding residues [ion binding]; other site 460265002952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265002953 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265002954 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265002955 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 460265002956 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 460265002957 fructokinase; Reviewed; Region: PRK09557 460265002958 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 460265002959 nucleotide binding site [chemical binding]; other site 460265002960 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 460265002961 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265002962 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 460265002963 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265002964 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 460265002965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265002966 putative substrate translocation pore; other site 460265002967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265002968 Cation efflux family; Region: Cation_efflux; pfam01545 460265002969 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 460265002970 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 460265002971 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265002972 catalytic loop [active] 460265002973 iron binding site [ion binding]; other site 460265002974 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 460265002975 cyclase homology domain; Region: CHD; cd07302 460265002976 nucleotidyl binding site; other site 460265002977 metal binding site [ion binding]; metal-binding site 460265002978 dimer interface [polypeptide binding]; other site 460265002979 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 460265002980 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265002981 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265002982 catalytic residue [active] 460265002983 Methyltransferase domain; Region: Methyltransf_23; pfam13489 460265002984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265002985 S-adenosylmethionine binding site [chemical binding]; other site 460265002986 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265002987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265002988 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 460265002989 putative dimerization interface [polypeptide binding]; other site 460265002990 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 460265002991 phosphoribulokinase; Provisional; Region: PRK15453 460265002992 active site 460265002993 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 460265002994 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 460265002995 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265002996 hypothetical protein; Provisional; Region: PRK08317 460265002997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265002998 S-adenosylmethionine binding site [chemical binding]; other site 460265002999 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 460265003000 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 460265003001 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 460265003002 motif II; other site 460265003003 GAF domain; Region: GAF_2; pfam13185 460265003004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 460265003005 Histidine kinase; Region: HisKA_2; pfam07568 460265003006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265003007 ATP binding site [chemical binding]; other site 460265003008 Mg2+ binding site [ion binding]; other site 460265003009 G-X-G motif; other site 460265003010 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 460265003011 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265003012 substrate binding pocket [chemical binding]; other site 460265003013 membrane-bound complex binding site; other site 460265003014 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 460265003015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265003016 dimer interface [polypeptide binding]; other site 460265003017 conserved gate region; other site 460265003018 putative PBP binding loops; other site 460265003019 ABC-ATPase subunit interface; other site 460265003020 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 460265003021 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 460265003022 Walker A/P-loop; other site 460265003023 ATP binding site [chemical binding]; other site 460265003024 Q-loop/lid; other site 460265003025 ABC transporter signature motif; other site 460265003026 Walker B; other site 460265003027 D-loop; other site 460265003028 H-loop/switch region; other site 460265003029 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 460265003030 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 460265003031 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 460265003032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265003033 non-specific DNA binding site [nucleotide binding]; other site 460265003034 salt bridge; other site 460265003035 sequence-specific DNA binding site [nucleotide binding]; other site 460265003036 META domain; Region: META; pfam03724 460265003037 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265003038 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 460265003039 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265003040 TM-ABC transporter signature motif; other site 460265003041 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265003042 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 460265003043 TM-ABC transporter signature motif; other site 460265003044 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265003045 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265003046 Walker A/P-loop; other site 460265003047 ATP binding site [chemical binding]; other site 460265003048 Q-loop/lid; other site 460265003049 ABC transporter signature motif; other site 460265003050 Walker B; other site 460265003051 D-loop; other site 460265003052 H-loop/switch region; other site 460265003053 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265003054 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265003055 Walker A/P-loop; other site 460265003056 ATP binding site [chemical binding]; other site 460265003057 Q-loop/lid; other site 460265003058 ABC transporter signature motif; other site 460265003059 Walker B; other site 460265003060 D-loop; other site 460265003061 H-loop/switch region; other site 460265003062 Homeodomain-like domain; Region: HTH_23; cl17451 460265003063 Winged helix-turn helix; Region: HTH_29; pfam13551 460265003064 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 460265003065 Integrase core domain; Region: rve; pfam00665 460265003066 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 460265003067 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 460265003068 catalytic residues [active] 460265003069 catalytic nucleophile [active] 460265003070 Recombinase; Region: Recombinase; pfam07508 460265003071 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 460265003072 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 460265003073 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 460265003074 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 460265003075 G1 box; other site 460265003076 putative GEF interaction site [polypeptide binding]; other site 460265003077 GTP/Mg2+ binding site [chemical binding]; other site 460265003078 Switch I region; other site 460265003079 G2 box; other site 460265003080 G3 box; other site 460265003081 Switch II region; other site 460265003082 G4 box; other site 460265003083 G5 box; other site 460265003084 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 460265003085 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 460265003086 hypothetical protein; Validated; Region: PRK00029 460265003087 Uncharacterized conserved protein [Function unknown]; Region: COG0397 460265003088 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 460265003089 putative FMN binding site [chemical binding]; other site 460265003090 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 460265003091 DNA-binding site [nucleotide binding]; DNA binding site 460265003092 RNA-binding motif; other site 460265003093 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 460265003094 DNA-binding site [nucleotide binding]; DNA binding site 460265003095 RNA-binding motif; other site 460265003096 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 460265003097 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 460265003098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265003099 Walker A motif; other site 460265003100 ATP binding site [chemical binding]; other site 460265003101 Walker B motif; other site 460265003102 arginine finger; other site 460265003103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265003104 Walker A motif; other site 460265003105 ATP binding site [chemical binding]; other site 460265003106 Walker B motif; other site 460265003107 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 460265003108 Uncharacterized conserved protein [Function unknown]; Region: COG2127 460265003109 Phasin protein; Region: Phasin_2; pfam09361 460265003110 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 460265003111 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 460265003112 Sporulation related domain; Region: SPOR; pfam05036 460265003113 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 460265003114 HSP70 interaction site [polypeptide binding]; other site 460265003115 von Willebrand factor type A domain; Region: VWA_2; pfam13519 460265003116 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 460265003117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 460265003118 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 460265003119 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 460265003120 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 460265003121 glutamate racemase; Provisional; Region: PRK00865 460265003122 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 460265003123 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 460265003124 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 460265003125 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 460265003126 RNA binding surface [nucleotide binding]; other site 460265003127 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 460265003128 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 460265003129 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 460265003130 active site 460265003131 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 460265003132 UbiA prenyltransferase family; Region: UbiA; pfam01040 460265003133 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 460265003134 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 460265003135 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 460265003136 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 460265003137 CysZ-like protein; Reviewed; Region: PRK12768 460265003138 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 460265003139 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 460265003140 putative NAD(P) binding site [chemical binding]; other site 460265003141 active site 460265003142 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 460265003143 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265003144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265003145 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265003146 hypothetical protein; Provisional; Region: PRK07208 460265003147 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 460265003148 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 460265003149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 460265003150 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 460265003151 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 460265003152 dimerization interface [polypeptide binding]; other site 460265003153 ligand binding site [chemical binding]; other site 460265003154 NADP binding site [chemical binding]; other site 460265003155 catalytic site [active] 460265003156 Bacterial SH3 domain; Region: SH3_4; pfam06347 460265003157 Bacterial SH3 domain; Region: SH3_4; pfam06347 460265003158 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 460265003159 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 460265003160 metal binding site 2 [ion binding]; metal-binding site 460265003161 putative DNA binding helix; other site 460265003162 metal binding site 1 [ion binding]; metal-binding site 460265003163 dimer interface [polypeptide binding]; other site 460265003164 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 460265003165 active site 1 [active] 460265003166 dimer interface [polypeptide binding]; other site 460265003167 active site 2 [active] 460265003168 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 460265003169 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 460265003170 dimer interface [polypeptide binding]; other site 460265003171 active site 460265003172 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 460265003173 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 460265003174 NAD binding site [chemical binding]; other site 460265003175 homotetramer interface [polypeptide binding]; other site 460265003176 homodimer interface [polypeptide binding]; other site 460265003177 substrate binding site [chemical binding]; other site 460265003178 active site 460265003179 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 460265003180 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 460265003181 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 460265003182 active site 460265003183 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 460265003184 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 460265003185 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 460265003186 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 460265003187 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 460265003188 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 460265003189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265003190 active site 460265003191 phosphorylation site [posttranslational modification] 460265003192 intermolecular recognition site; other site 460265003193 dimerization interface [polypeptide binding]; other site 460265003194 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 460265003195 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 460265003196 active site 460265003197 Riboflavin kinase; Region: Flavokinase; pfam01687 460265003198 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 460265003199 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 460265003200 active site 460265003201 HIGH motif; other site 460265003202 nucleotide binding site [chemical binding]; other site 460265003203 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 460265003204 active site 460265003205 KMSKS motif; other site 460265003206 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 460265003207 tRNA binding surface [nucleotide binding]; other site 460265003208 anticodon binding site; other site 460265003209 lipoprotein signal peptidase; Provisional; Region: PRK14796 460265003210 lipoprotein signal peptidase; Provisional; Region: PRK14787 460265003211 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 460265003212 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 460265003213 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 460265003214 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 460265003215 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 460265003216 Cupin domain; Region: Cupin_2; cl17218 460265003217 UreD urease accessory protein; Region: UreD; pfam01774 460265003218 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 460265003219 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 460265003220 alpha-gamma subunit interface [polypeptide binding]; other site 460265003221 beta-gamma subunit interface [polypeptide binding]; other site 460265003222 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 460265003223 alpha-beta subunit interface [polypeptide binding]; other site 460265003224 urease subunit alpha; Reviewed; Region: ureC; PRK13207 460265003225 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 460265003226 subunit interactions [polypeptide binding]; other site 460265003227 active site 460265003228 flap region; other site 460265003229 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 460265003230 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 460265003231 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 460265003232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265003233 dimer interface [polypeptide binding]; other site 460265003234 conserved gate region; other site 460265003235 putative PBP binding loops; other site 460265003236 ABC-ATPase subunit interface; other site 460265003237 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 460265003238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265003239 dimer interface [polypeptide binding]; other site 460265003240 conserved gate region; other site 460265003241 putative PBP binding loops; other site 460265003242 ABC-ATPase subunit interface; other site 460265003243 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 460265003244 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265003245 Walker A/P-loop; other site 460265003246 ATP binding site [chemical binding]; other site 460265003247 Q-loop/lid; other site 460265003248 ABC transporter signature motif; other site 460265003249 Walker B; other site 460265003250 D-loop; other site 460265003251 H-loop/switch region; other site 460265003252 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 460265003253 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265003254 Walker A/P-loop; other site 460265003255 ATP binding site [chemical binding]; other site 460265003256 Q-loop/lid; other site 460265003257 ABC transporter signature motif; other site 460265003258 Walker B; other site 460265003259 D-loop; other site 460265003260 H-loop/switch region; other site 460265003261 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 460265003262 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 460265003263 Peptidase family M23; Region: Peptidase_M23; pfam01551 460265003264 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265003265 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 460265003266 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 460265003267 putative active site [active] 460265003268 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 460265003269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265003270 Walker A/P-loop; other site 460265003271 ATP binding site [chemical binding]; other site 460265003272 Q-loop/lid; other site 460265003273 ABC transporter signature motif; other site 460265003274 Walker B; other site 460265003275 D-loop; other site 460265003276 H-loop/switch region; other site 460265003277 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 460265003278 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265003279 Walker A/P-loop; other site 460265003280 ATP binding site [chemical binding]; other site 460265003281 Q-loop/lid; other site 460265003282 ABC transporter signature motif; other site 460265003283 Walker B; other site 460265003284 D-loop; other site 460265003285 H-loop/switch region; other site 460265003286 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 460265003287 propionate/acetate kinase; Provisional; Region: PRK12379 460265003288 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 460265003289 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 460265003290 dimer interaction site [polypeptide binding]; other site 460265003291 substrate-binding tunnel; other site 460265003292 active site 460265003293 catalytic site [active] 460265003294 substrate binding site [chemical binding]; other site 460265003295 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 460265003296 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 460265003297 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 460265003298 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 460265003299 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 460265003300 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265003301 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 460265003302 ligand binding site [chemical binding]; other site 460265003303 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 460265003304 thiamine pyrophosphate protein; Provisional; Region: PRK08273 460265003305 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 460265003306 PYR/PP interface [polypeptide binding]; other site 460265003307 dimer interface [polypeptide binding]; other site 460265003308 tetramer interface [polypeptide binding]; other site 460265003309 TPP binding site [chemical binding]; other site 460265003310 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 460265003311 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 460265003312 TPP-binding site [chemical binding]; other site 460265003313 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 460265003314 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 460265003315 metal binding site [ion binding]; metal-binding site 460265003316 substrate binding pocket [chemical binding]; other site 460265003317 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 460265003318 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 460265003319 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 460265003320 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 460265003321 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 460265003322 short chain dehydrogenase; Provisional; Region: PRK07109 460265003323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265003324 NAD(P) binding site [chemical binding]; other site 460265003325 active site 460265003326 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 460265003327 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 460265003328 Trp docking motif [polypeptide binding]; other site 460265003329 dimer interface [polypeptide binding]; other site 460265003330 active site 460265003331 small subunit binding site [polypeptide binding]; other site 460265003332 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265003333 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265003334 ligand binding site [chemical binding]; other site 460265003335 flexible hinge region; other site 460265003336 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 460265003337 putative switch regulator; other site 460265003338 non-specific DNA interactions [nucleotide binding]; other site 460265003339 DNA binding site [nucleotide binding] 460265003340 sequence specific DNA binding site [nucleotide binding]; other site 460265003341 putative cAMP binding site [chemical binding]; other site 460265003342 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 460265003343 Ligand Binding Site [chemical binding]; other site 460265003344 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 460265003345 Ligand Binding Site [chemical binding]; other site 460265003346 Protein of unknown function (DUF465); Region: DUF465; pfam04325 460265003347 OmpW family; Region: OmpW; cl17427 460265003348 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 460265003349 GAF domain; Region: GAF; pfam01590 460265003350 PAS domain S-box; Region: sensory_box; TIGR00229 460265003351 PAS domain; Region: PAS_8; pfam13188 460265003352 PAS fold; Region: PAS_4; pfam08448 460265003353 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265003354 putative active site [active] 460265003355 heme pocket [chemical binding]; other site 460265003356 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 460265003357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265003358 putative active site [active] 460265003359 heme pocket [chemical binding]; other site 460265003360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265003361 dimer interface [polypeptide binding]; other site 460265003362 phosphorylation site [posttranslational modification] 460265003363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265003364 ATP binding site [chemical binding]; other site 460265003365 Mg2+ binding site [ion binding]; other site 460265003366 G-X-G motif; other site 460265003367 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 460265003368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265003369 active site 460265003370 phosphorylation site [posttranslational modification] 460265003371 intermolecular recognition site; other site 460265003372 dimerization interface [polypeptide binding]; other site 460265003373 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265003374 PAS domain; Region: PAS_9; pfam13426 460265003375 putative active site [active] 460265003376 heme pocket [chemical binding]; other site 460265003377 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 460265003378 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 460265003379 metal binding site [ion binding]; metal-binding site 460265003380 active site 460265003381 I-site; other site 460265003382 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 460265003383 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 460265003384 Transglycosylase SLT domain; Region: SLT_2; pfam13406 460265003385 murein hydrolase B; Provisional; Region: PRK10760; cl17906 460265003386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265003387 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 460265003388 NAD(P) binding site [chemical binding]; other site 460265003389 active site 460265003390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265003391 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 460265003392 NAD(P) binding site [chemical binding]; other site 460265003393 active site 460265003394 B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295 460265003395 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 460265003396 B12 binding site [chemical binding]; other site 460265003397 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265003398 FeS/SAM binding site; other site 460265003399 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265003400 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 460265003401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 460265003402 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 460265003403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 460265003404 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 460265003405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 460265003406 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 460265003407 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 460265003408 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 460265003409 NAD binding site [chemical binding]; other site 460265003410 putative substrate binding site 2 [chemical binding]; other site 460265003411 putative substrate binding site 1 [chemical binding]; other site 460265003412 active site 460265003413 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 460265003414 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 460265003415 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 460265003416 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 460265003417 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265003418 Zn binding site [ion binding]; other site 460265003419 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 460265003420 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265003421 Zn binding site [ion binding]; other site 460265003422 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 460265003423 catalytic core [active] 460265003424 dihydrodipicolinate reductase; Provisional; Region: PRK00048 460265003425 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 460265003426 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 460265003427 MarC family integral membrane protein; Region: MarC; cl00919 460265003428 Methyltransferase domain; Region: Methyltransf_23; pfam13489 460265003429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265003430 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 460265003431 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 460265003432 aromatic amino acid exporter; Provisional; Region: PRK11689 460265003433 EamA-like transporter family; Region: EamA; pfam00892 460265003434 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 460265003435 dihydroxy-acid dehydratase; Validated; Region: PRK06131 460265003436 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 460265003437 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 460265003438 Cl binding site [ion binding]; other site 460265003439 oligomer interface [polypeptide binding]; other site 460265003440 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 460265003441 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 460265003442 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 460265003443 Ligand binding site [chemical binding]; other site 460265003444 Electron transfer flavoprotein domain; Region: ETF; pfam01012 460265003445 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 460265003446 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 460265003447 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 460265003448 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 460265003449 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 460265003450 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 460265003451 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 460265003452 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 460265003453 NAD(P) binding site [chemical binding]; other site 460265003454 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 460265003455 active site 460265003456 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 460265003457 hypothetical protein; Validated; Region: PRK07198 460265003458 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 460265003459 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 460265003460 dimerization interface [polypeptide binding]; other site 460265003461 active site 460265003462 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 460265003463 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 460265003464 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 460265003465 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 460265003466 protein binding site [polypeptide binding]; other site 460265003467 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 460265003468 protein binding site [polypeptide binding]; other site 460265003469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265003470 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 460265003471 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 460265003472 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265003473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265003474 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265003475 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265003476 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 460265003477 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 460265003478 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 460265003479 protein binding site [polypeptide binding]; other site 460265003480 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265003481 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265003482 DNA binding residues [nucleotide binding] 460265003483 dimerization interface [polypeptide binding]; other site 460265003484 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 460265003485 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 460265003486 protein binding site [polypeptide binding]; other site 460265003487 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 460265003488 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 460265003489 Walker A/P-loop; other site 460265003490 ATP binding site [chemical binding]; other site 460265003491 Q-loop/lid; other site 460265003492 ABC transporter signature motif; other site 460265003493 Walker B; other site 460265003494 D-loop; other site 460265003495 H-loop/switch region; other site 460265003496 ABC-2 type transporter; Region: ABC2_membrane; cl17235 460265003497 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 460265003498 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265003499 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265003500 DNA-binding site [nucleotide binding]; DNA binding site 460265003501 FCD domain; Region: FCD; pfam07729 460265003502 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 460265003503 short chain dehydrogenase; Provisional; Region: PRK06139 460265003504 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 460265003505 putative NAD(P) binding site [chemical binding]; other site 460265003506 active site 460265003507 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 460265003508 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 460265003509 active site 460265003510 metal binding site [ion binding]; metal-binding site 460265003511 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 460265003512 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 460265003513 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 460265003514 active site 460265003515 catalytic site [active] 460265003516 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 460265003517 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 460265003518 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 460265003519 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 460265003520 putative active site [active] 460265003521 putative metal binding site [ion binding]; other site 460265003522 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 460265003523 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 460265003524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265003525 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 460265003526 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 460265003527 dimerization interface [polypeptide binding]; other site 460265003528 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 460265003529 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265003530 Walker A/P-loop; other site 460265003531 ATP binding site [chemical binding]; other site 460265003532 Q-loop/lid; other site 460265003533 ABC transporter signature motif; other site 460265003534 Walker B; other site 460265003535 D-loop; other site 460265003536 H-loop/switch region; other site 460265003537 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 460265003538 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 460265003539 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265003540 Walker A/P-loop; other site 460265003541 ATP binding site [chemical binding]; other site 460265003542 Q-loop/lid; other site 460265003543 ABC transporter signature motif; other site 460265003544 Walker B; other site 460265003545 D-loop; other site 460265003546 H-loop/switch region; other site 460265003547 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 460265003548 dipeptide transporter; Provisional; Region: PRK10913 460265003549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265003550 dimer interface [polypeptide binding]; other site 460265003551 conserved gate region; other site 460265003552 putative PBP binding loops; other site 460265003553 ABC-ATPase subunit interface; other site 460265003554 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 460265003555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265003556 dimer interface [polypeptide binding]; other site 460265003557 conserved gate region; other site 460265003558 putative PBP binding loops; other site 460265003559 ABC-ATPase subunit interface; other site 460265003560 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 460265003561 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 460265003562 peptide binding site [polypeptide binding]; other site 460265003563 Ligase N family; Region: LIGANc; smart00532 460265003564 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 460265003565 nucleotide binding pocket [chemical binding]; other site 460265003566 K-X-D-G motif; other site 460265003567 catalytic site [active] 460265003568 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 460265003569 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 460265003570 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 460265003571 Dimer interface [polypeptide binding]; other site 460265003572 BRCT sequence motif; other site 460265003573 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 460265003574 active site 460265003575 catalytic site [active] 460265003576 substrate binding site [chemical binding]; other site 460265003577 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 460265003578 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 460265003579 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 460265003580 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 460265003581 putative catalytic site [active] 460265003582 putative metal binding site [ion binding]; other site 460265003583 putative phosphate binding site [ion binding]; other site 460265003584 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 460265003585 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 460265003586 putative active site [active] 460265003587 catalytic site [active] 460265003588 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 460265003589 putative active site [active] 460265003590 catalytic site [active] 460265003591 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 460265003592 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 460265003593 amidase; Provisional; Region: PRK07486 460265003594 Amidase; Region: Amidase; cl11426 460265003595 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 460265003596 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 460265003597 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 460265003598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265003599 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 460265003600 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 460265003601 DNA binding site [nucleotide binding] 460265003602 active site 460265003603 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 460265003604 Transglycosylase; Region: Transgly; pfam00912 460265003605 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 460265003606 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 460265003607 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 460265003608 purine nucleoside phosphorylase; Provisional; Region: PRK08202 460265003609 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 460265003610 active site 460265003611 catalytic motif [active] 460265003612 Zn binding site [ion binding]; other site 460265003613 prephenate dehydratase; Provisional; Region: PRK11899 460265003614 Prephenate dehydratase; Region: PDT; pfam00800 460265003615 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 460265003616 putative L-Phe binding site [chemical binding]; other site 460265003617 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 460265003618 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 460265003619 Ligand binding site; other site 460265003620 oligomer interface; other site 460265003621 Cytochrome c2 [Energy production and conversion]; Region: COG3474 460265003622 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 460265003623 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 460265003624 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 460265003625 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 460265003626 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 460265003627 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 460265003628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265003629 dimer interface [polypeptide binding]; other site 460265003630 conserved gate region; other site 460265003631 putative PBP binding loops; other site 460265003632 ABC-ATPase subunit interface; other site 460265003633 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 460265003634 active site 460265003635 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 460265003636 FAD binding domain; Region: FAD_binding_4; pfam01565 460265003637 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 460265003638 recombination regulator RecX; Reviewed; Region: recX; PRK00117 460265003639 Predicted membrane protein [Function unknown]; Region: COG2323 460265003640 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 460265003641 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 460265003642 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 460265003643 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 460265003644 Protein export membrane protein; Region: SecD_SecF; cl14618 460265003645 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 460265003646 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265003647 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265003648 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 460265003649 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 460265003650 active site 460265003651 catalytic tetrad [active] 460265003652 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 460265003653 active site 460265003654 Zn binding site [ion binding]; other site 460265003655 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 460265003656 Helix-turn-helix domain; Region: HTH_18; pfam12833 460265003657 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265003658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 460265003659 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 460265003660 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 460265003661 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 460265003662 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 460265003663 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 460265003664 Catalytic site [active] 460265003665 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 460265003666 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 460265003667 catalytic residue [active] 460265003668 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 460265003669 Phage Tail Protein X; Region: Phage_tail_X; cl02088 460265003670 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 460265003671 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 460265003672 virion protein; Provisional; Region: V; PHA02564 460265003673 Prophage antirepressor [Transcription]; Region: COG3617 460265003674 BRO family, N-terminal domain; Region: Bro-N; smart01040 460265003675 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 460265003676 Phage tail tube protein FII; Region: Phage_tube; cl01390 460265003677 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 460265003678 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 460265003679 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265003680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 460265003681 Winged helix-turn helix; Region: HTH_29; pfam13551 460265003682 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265003683 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 460265003684 Baseplate J-like protein; Region: Baseplate_J; cl01294 460265003685 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 460265003686 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 460265003687 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 460265003688 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 460265003689 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 460265003690 tandem repeat interface [polypeptide binding]; other site 460265003691 oligomer interface [polypeptide binding]; other site 460265003692 active site residues [active] 460265003693 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 460265003694 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 460265003695 gpW; Region: gpW; pfam02831 460265003696 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 460265003697 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 460265003698 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 460265003699 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265003700 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 460265003701 non-specific DNA binding site [nucleotide binding]; other site 460265003702 salt bridge; other site 460265003703 sequence-specific DNA binding site [nucleotide binding]; other site 460265003704 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 460265003705 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 460265003706 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 460265003707 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 460265003708 Winged helix-turn helix; Region: HTH_29; pfam13551 460265003709 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265003710 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 460265003711 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265003712 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 460265003713 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 460265003714 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 460265003715 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 460265003716 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 460265003717 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 460265003718 Active Sites [active] 460265003719 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265003720 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265003721 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265003722 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265003723 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265003724 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265003725 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265003726 Oxysterol-binding protein; Region: Oxysterol_BP; pfam01237 460265003727 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 460265003728 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 460265003729 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 460265003730 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 460265003731 catalytic residue [active] 460265003732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265003733 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265003734 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265003735 Transcriptional regulators [Transcription]; Region: PurR; COG1609 460265003736 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 460265003737 DNA binding site [nucleotide binding] 460265003738 domain linker motif; other site 460265003739 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 460265003740 putative dimerization interface [polypeptide binding]; other site 460265003741 putative ligand binding site [chemical binding]; other site 460265003742 Protein of unknown function (DUF993); Region: DUF993; pfam06187 460265003743 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 460265003744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265003745 NAD(P) binding site [chemical binding]; other site 460265003746 active site 460265003747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265003748 metabolite-proton symporter; Region: 2A0106; TIGR00883 460265003749 putative substrate translocation pore; other site 460265003750 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 460265003751 Coenzyme A transferase; Region: CoA_trans; smart00882 460265003752 Coenzyme A transferase; Region: CoA_trans; cl17247 460265003753 enoyl-CoA hydratase; Provisional; Region: PRK08138 460265003754 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265003755 substrate binding site [chemical binding]; other site 460265003756 oxyanion hole (OAH) forming residues; other site 460265003757 trimer interface [polypeptide binding]; other site 460265003758 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 460265003759 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 460265003760 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 460265003761 MOFRL family; Region: MOFRL; pfam05161 460265003762 pyruvate kinase; Provisional; Region: PRK06247 460265003763 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 460265003764 domain interfaces; other site 460265003765 active site 460265003766 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 460265003767 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265003768 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 460265003769 putative dimerization interface [polypeptide binding]; other site 460265003770 putative substrate binding pocket [chemical binding]; other site 460265003771 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 460265003772 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 460265003773 active site 460265003774 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265003775 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265003776 putative ligand binding site [chemical binding]; other site 460265003777 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 460265003778 CoA-transferase family III; Region: CoA_transf_3; pfam02515 460265003779 tellurium resistance terB-like protein; Region: terB_like; cl11965 460265003780 metal binding site [ion binding]; metal-binding site 460265003781 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 460265003782 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 460265003783 catalytic triad [active] 460265003784 LrgA family; Region: LrgA; pfam03788 460265003785 LrgB-like family; Region: LrgB; pfam04172 460265003786 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 460265003787 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 460265003788 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 460265003789 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 460265003790 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 460265003791 AAA domain; Region: AAA_31; pfam13614 460265003792 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 460265003793 P-loop; other site 460265003794 Magnesium ion binding site [ion binding]; other site 460265003795 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 460265003796 Magnesium ion binding site [ion binding]; other site 460265003797 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 460265003798 putative hydrophobic ligand binding site [chemical binding]; other site 460265003799 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 460265003800 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 460265003801 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 460265003802 ring oligomerisation interface [polypeptide binding]; other site 460265003803 ATP/Mg binding site [chemical binding]; other site 460265003804 stacking interactions; other site 460265003805 hinge regions; other site 460265003806 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 460265003807 oligomerisation interface [polypeptide binding]; other site 460265003808 mobile loop; other site 460265003809 roof hairpin; other site 460265003810 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 460265003811 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 460265003812 oligomer interface [polypeptide binding]; other site 460265003813 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 460265003814 FAD binding domain; Region: FAD_binding_4; pfam01565 460265003815 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 460265003816 Cysteine-rich domain; Region: CCG; pfam02754 460265003817 Cysteine-rich domain; Region: CCG; pfam02754 460265003818 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 460265003819 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 460265003820 active site 460265003821 ADP/pyrophosphate binding site [chemical binding]; other site 460265003822 dimerization interface [polypeptide binding]; other site 460265003823 allosteric effector site; other site 460265003824 fructose-1,6-bisphosphate binding site; other site 460265003825 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 460265003826 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 460265003827 NAD binding site [chemical binding]; other site 460265003828 homotetramer interface [polypeptide binding]; other site 460265003829 homodimer interface [polypeptide binding]; other site 460265003830 substrate binding site [chemical binding]; other site 460265003831 active site 460265003832 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 460265003833 putative deacylase active site [active] 460265003834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265003835 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265003836 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265003837 PhoH-like protein; Region: PhoH; pfam02562 460265003838 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 460265003839 Part of AAA domain; Region: AAA_19; pfam13245 460265003840 Family description; Region: UvrD_C_2; pfam13538 460265003841 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 460265003842 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 460265003843 dihydroorotase; Validated; Region: PRK09060 460265003844 Urease alpha-subunit, N-terminal domain; Region: Urease_alpha; pfam00449 460265003845 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 460265003846 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 460265003847 active site 460265003848 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 460265003849 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 460265003850 fumarate hydratase; Reviewed; Region: fumC; PRK00485 460265003851 Class II fumarases; Region: Fumarase_classII; cd01362 460265003852 active site 460265003853 tetramer interface [polypeptide binding]; other site 460265003854 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 460265003855 Cytochrome P450; Region: p450; cl12078 460265003856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 460265003857 thymidylate synthase; Reviewed; Region: thyA; PRK01827 460265003858 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 460265003859 dimerization interface [polypeptide binding]; other site 460265003860 active site 460265003861 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 460265003862 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 460265003863 folate binding site [chemical binding]; other site 460265003864 NADP+ binding site [chemical binding]; other site 460265003865 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 460265003866 HflK protein; Region: hflK; TIGR01933 460265003867 HflC protein; Region: hflC; TIGR01932 460265003868 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 460265003869 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 460265003870 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 460265003871 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 460265003872 protein binding site [polypeptide binding]; other site 460265003873 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 460265003874 protein binding site [polypeptide binding]; other site 460265003875 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 460265003876 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 460265003877 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 460265003878 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 460265003879 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 460265003880 SEC-C motif; Region: SEC-C; pfam02810 460265003881 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265003882 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265003883 putative ligand binding site [chemical binding]; other site 460265003884 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 460265003885 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 460265003886 metal-binding site [ion binding] 460265003887 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265003888 putative active site [active] 460265003889 heme pocket [chemical binding]; other site 460265003890 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265003891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265003892 dimer interface [polypeptide binding]; other site 460265003893 phosphorylation site [posttranslational modification] 460265003894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265003895 ATP binding site [chemical binding]; other site 460265003896 Mg2+ binding site [ion binding]; other site 460265003897 G-X-G motif; other site 460265003898 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 460265003899 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 460265003900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 460265003901 Predicted integral membrane protein [Function unknown]; Region: COG5436 460265003902 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 460265003903 Transglycosylase; Region: Transgly; pfam00912 460265003904 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 460265003905 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 460265003906 hypothetical protein; Provisional; Region: PRK05170 460265003907 glutathione synthetase; Provisional; Region: PRK05246 460265003908 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 460265003909 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 460265003910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265003911 putative transporter; Provisional; Region: PRK10504 460265003912 putative substrate translocation pore; other site 460265003913 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 460265003914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 460265003915 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 460265003916 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 460265003917 hypothetical protein; Provisional; Region: PRK06034 460265003918 Chorismate mutase type II; Region: CM_2; cl00693 460265003919 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 460265003920 active site 460265003921 phosphodiesterase YaeI; Provisional; Region: PRK11340 460265003922 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 460265003923 putative active site [active] 460265003924 putative metal binding site [ion binding]; other site 460265003925 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 460265003926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265003927 Walker A motif; other site 460265003928 ATP binding site [chemical binding]; other site 460265003929 Walker B motif; other site 460265003930 arginine finger; other site 460265003931 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 460265003932 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 460265003933 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 460265003934 heme binding site [chemical binding]; other site 460265003935 ferroxidase pore; other site 460265003936 ferroxidase diiron center [ion binding]; other site 460265003937 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 460265003938 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 460265003939 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265003940 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 460265003941 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265003942 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265003943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265003944 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 460265003945 dimer interface [polypeptide binding]; other site 460265003946 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 460265003947 MoaE homodimer interface [polypeptide binding]; other site 460265003948 MoaD interaction [polypeptide binding]; other site 460265003949 active site residues [active] 460265003950 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 460265003951 trimer interface [polypeptide binding]; other site 460265003952 putative metal binding site [ion binding]; other site 460265003953 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 460265003954 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 460265003955 trimer interface [polypeptide binding]; other site 460265003956 putative metal binding site [ion binding]; other site 460265003957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265003958 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265003959 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265003960 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 460265003961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265003962 S-adenosylmethionine binding site [chemical binding]; other site 460265003963 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 460265003964 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 460265003965 tetramerization interface [polypeptide binding]; other site 460265003966 NAD(P) binding site [chemical binding]; other site 460265003967 catalytic residues [active] 460265003968 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 460265003969 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 460265003970 dimer interface [polypeptide binding]; other site 460265003971 active site 460265003972 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 460265003973 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 460265003974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265003975 putative substrate translocation pore; other site 460265003976 Major Facilitator Superfamily; Region: MFS_1; pfam07690 460265003977 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 460265003978 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 460265003979 hypothetical protein; Provisional; Region: PRK13560 460265003980 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 460265003981 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265003982 DNA-binding site [nucleotide binding]; DNA binding site 460265003983 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 460265003984 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 460265003985 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 460265003986 tetramer interface [polypeptide binding]; other site 460265003987 active site 460265003988 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 460265003989 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 460265003990 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 460265003991 dimer interface [polypeptide binding]; other site 460265003992 putative CheW interface [polypeptide binding]; other site 460265003993 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 460265003994 dimer interface [polypeptide binding]; other site 460265003995 putative CheW interface [polypeptide binding]; other site 460265003996 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 460265003997 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 460265003998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265003999 active site 460265004000 phosphorylation site [posttranslational modification] 460265004001 intermolecular recognition site; other site 460265004002 CheB methylesterase; Region: CheB_methylest; pfam01339 460265004003 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 460265004004 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 460265004005 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 460265004006 Response regulator receiver domain; Region: Response_reg; pfam00072 460265004007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265004008 active site 460265004009 phosphorylation site [posttranslational modification] 460265004010 intermolecular recognition site; other site 460265004011 dimerization interface [polypeptide binding]; other site 460265004012 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 460265004013 putative binding surface; other site 460265004014 active site 460265004015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265004016 ATP binding site [chemical binding]; other site 460265004017 Mg2+ binding site [ion binding]; other site 460265004018 G-X-G motif; other site 460265004019 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 460265004020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265004021 Response regulator receiver domain; Region: Response_reg; pfam00072 460265004022 active site 460265004023 phosphorylation site [posttranslational modification] 460265004024 intermolecular recognition site; other site 460265004025 dimerization interface [polypeptide binding]; other site 460265004026 Chemotaxis phosphatase CheX; Region: CheX; cl15816 460265004027 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 460265004028 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265004029 PAS domain; Region: PAS_9; pfam13426 460265004030 putative active site [active] 460265004031 heme pocket [chemical binding]; other site 460265004032 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265004033 PAS fold; Region: PAS_3; pfam08447 460265004034 putative active site [active] 460265004035 heme pocket [chemical binding]; other site 460265004036 PAS domain S-box; Region: sensory_box; TIGR00229 460265004037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265004038 dimer interface [polypeptide binding]; other site 460265004039 phosphorylation site [posttranslational modification] 460265004040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265004041 ATP binding site [chemical binding]; other site 460265004042 Mg2+ binding site [ion binding]; other site 460265004043 G-X-G motif; other site 460265004044 Response regulator receiver domain; Region: Response_reg; pfam00072 460265004045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265004046 active site 460265004047 phosphorylation site [posttranslational modification] 460265004048 intermolecular recognition site; other site 460265004049 dimerization interface [polypeptide binding]; other site 460265004050 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 460265004051 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 460265004052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265004053 active site 460265004054 phosphorylation site [posttranslational modification] 460265004055 intermolecular recognition site; other site 460265004056 dimerization interface [polypeptide binding]; other site 460265004057 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265004058 DNA binding site [nucleotide binding] 460265004059 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 460265004060 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 460265004061 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 460265004062 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 460265004063 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 460265004064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265004065 Walker B motif; other site 460265004066 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 460265004067 hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367 460265004068 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 460265004069 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265004070 FeS/SAM binding site; other site 460265004071 HD domain; Region: HD_4; pfam13328 460265004072 Predicted integral membrane protein (DUF2270); Region: DUF2270; cl02337 460265004073 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 460265004074 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 460265004075 active site 460265004076 metal binding site [ion binding]; metal-binding site 460265004077 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 460265004078 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 460265004079 RNA polymerase sigma factor; Provisional; Region: PRK11924 460265004080 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265004081 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 460265004082 DNA binding residues [nucleotide binding] 460265004083 Putative zinc-finger; Region: zf-HC2; pfam13490 460265004084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265004085 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265004086 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265004087 MgtC family; Region: MgtC; pfam02308 460265004088 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 460265004089 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 460265004090 CRISPR-associated protein Cas4; Region: cas4; TIGR00372 460265004091 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 460265004092 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 460265004093 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 460265004094 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 460265004095 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 460265004096 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 460265004097 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 460265004098 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 460265004099 active site 460265004100 substrate binding site [chemical binding]; other site 460265004101 Mg2+ binding site [ion binding]; other site 460265004102 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 460265004103 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 460265004104 YHS domain; Region: YHS; pfam04945 460265004105 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 460265004106 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 460265004107 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 460265004108 active site 460265004109 motif I; other site 460265004110 motif II; other site 460265004111 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 460265004112 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 460265004113 DNA binding residues [nucleotide binding] 460265004114 dimer interface [polypeptide binding]; other site 460265004115 copper binding site [ion binding]; other site 460265004116 benzoate transport; Region: 2A0115; TIGR00895 460265004117 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 460265004118 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265004119 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 460265004120 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265004121 acyl-activating enzyme (AAE) consensus motif; other site 460265004122 acyl-activating enzyme (AAE) consensus motif; other site 460265004123 AMP binding site [chemical binding]; other site 460265004124 active site 460265004125 CoA binding site [chemical binding]; other site 460265004126 enoyl-CoA hydratase; Provisional; Region: PRK08290 460265004127 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265004128 substrate binding site [chemical binding]; other site 460265004129 oxyanion hole (OAH) forming residues; other site 460265004130 trimer interface [polypeptide binding]; other site 460265004131 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265004132 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265004133 putative ligand binding site [chemical binding]; other site 460265004134 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 460265004135 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 460265004136 NADP binding site [chemical binding]; other site 460265004137 dimer interface [polypeptide binding]; other site 460265004138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265004139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265004140 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 460265004141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265004142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265004143 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 460265004144 cyclase homology domain; Region: CHD; cd07302 460265004145 nucleotidyl binding site; other site 460265004146 metal binding site [ion binding]; metal-binding site 460265004147 dimer interface [polypeptide binding]; other site 460265004148 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 460265004149 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 460265004150 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 460265004151 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 460265004152 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 460265004153 catalytic residues [active] 460265004154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265004155 osmolarity response regulator; Provisional; Region: ompR; PRK09468 460265004156 active site 460265004157 phosphorylation site [posttranslational modification] 460265004158 intermolecular recognition site; other site 460265004159 dimerization interface [polypeptide binding]; other site 460265004160 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265004161 DNA binding site [nucleotide binding] 460265004162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 460265004163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265004164 ATP binding site [chemical binding]; other site 460265004165 Mg2+ binding site [ion binding]; other site 460265004166 G-X-G motif; other site 460265004167 Nitronate monooxygenase; Region: NMO; pfam03060 460265004168 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 460265004169 FMN binding site [chemical binding]; other site 460265004170 substrate binding site [chemical binding]; other site 460265004171 putative catalytic residue [active] 460265004172 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 460265004173 active site 1 [active] 460265004174 dimer interface [polypeptide binding]; other site 460265004175 hexamer interface [polypeptide binding]; other site 460265004176 active site 2 [active] 460265004177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265004178 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 460265004179 NAD(P) binding site [chemical binding]; other site 460265004180 active site 460265004181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265004182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265004183 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265004184 dimerization interface [polypeptide binding]; other site 460265004185 phenol 2-monooxygenase; Provisional; Region: PRK08294 460265004186 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 460265004187 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 460265004188 dimer interface [polypeptide binding]; other site 460265004189 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 460265004190 MarR family; Region: MarR; pfam01047 460265004191 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 460265004192 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 460265004193 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 460265004194 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 460265004195 dimer interface [polypeptide binding]; other site 460265004196 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265004197 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 460265004198 Helix-turn-helix domain; Region: HTH_20; pfam12840 460265004199 putative DNA binding site [nucleotide binding]; other site 460265004200 putative Zn2+ binding site [ion binding]; other site 460265004201 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 460265004202 putative hydrophobic ligand binding site [chemical binding]; other site 460265004203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 460265004204 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 460265004205 EF-hand domain pair; Region: EF_hand_5; pfam13499 460265004206 Ca2+ binding site [ion binding]; other site 460265004207 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 460265004208 DNA-binding site [nucleotide binding]; DNA binding site 460265004209 RNA-binding motif; other site 460265004210 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 460265004211 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 460265004212 putative NAD(P) binding site [chemical binding]; other site 460265004213 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265004214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265004215 active site 460265004216 phosphorylation site [posttranslational modification] 460265004217 intermolecular recognition site; other site 460265004218 dimerization interface [polypeptide binding]; other site 460265004219 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265004220 DNA binding residues [nucleotide binding] 460265004221 dimerization interface [polypeptide binding]; other site 460265004222 Transposase domain (DUF772); Region: DUF772; pfam05598 460265004223 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265004224 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 460265004225 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265004226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265004227 active site 460265004228 phosphorylation site [posttranslational modification] 460265004229 intermolecular recognition site; other site 460265004230 dimerization interface [polypeptide binding]; other site 460265004231 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265004232 DNA binding residues [nucleotide binding] 460265004233 dimerization interface [polypeptide binding]; other site 460265004234 Bacterial sugar transferase; Region: Bac_transf; pfam02397 460265004235 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265004236 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 460265004237 putative ADP-binding pocket [chemical binding]; other site 460265004238 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 460265004239 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 460265004240 SLBB domain; Region: SLBB; pfam10531 460265004241 Chain length determinant protein; Region: Wzz; cl15801 460265004242 Chain length determinant protein; Region: Wzz; cl15801 460265004243 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 460265004244 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 460265004245 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 460265004246 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265004247 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 460265004248 active site 460265004249 catalytic residues [active] 460265004250 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 460265004251 Methyltransferase domain; Region: Methyltransf_23; pfam13489 460265004252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265004253 S-adenosylmethionine binding site [chemical binding]; other site 460265004254 Methyltransferase domain; Region: Methyltransf_23; pfam13489 460265004255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265004256 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 460265004257 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 460265004258 active site 460265004259 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 460265004260 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 460265004261 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 460265004262 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265004263 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 460265004264 Bacterial sugar transferase; Region: Bac_transf; pfam02397 460265004265 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 460265004266 extended (e) SDRs; Region: SDR_e; cd08946 460265004267 NAD(P) binding site [chemical binding]; other site 460265004268 active site 460265004269 substrate binding site [chemical binding]; other site 460265004270 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 460265004271 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 460265004272 inhibitor-cofactor binding pocket; inhibition site 460265004273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265004274 catalytic residue [active] 460265004275 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 460265004276 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 460265004277 Substrate binding site; other site 460265004278 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 460265004279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265004280 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265004281 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265004282 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 460265004283 ParB-like nuclease domain; Region: ParBc; pfam02195 460265004284 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 460265004285 DNA methylase; Region: N6_N4_Mtase; pfam01555 460265004286 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265004287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265004288 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265004289 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 460265004290 Putative transposase; Region: Y2_Tnp; pfam04986 460265004291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265004292 D-galactonate transporter; Region: 2A0114; TIGR00893 460265004293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265004294 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 460265004295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265004296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265004297 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 460265004298 dimerization interface [polypeptide binding]; other site 460265004299 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 460265004300 hypothetical protein; Validated; Region: PRK06201 460265004301 aspartate aminotransferase; Provisional; Region: PRK06107 460265004302 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 460265004303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265004304 homodimer interface [polypeptide binding]; other site 460265004305 catalytic residue [active] 460265004306 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 460265004307 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265004308 substrate binding pocket [chemical binding]; other site 460265004309 membrane-bound complex binding site; other site 460265004310 hinge residues; other site 460265004311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265004312 dimer interface [polypeptide binding]; other site 460265004313 conserved gate region; other site 460265004314 putative PBP binding loops; other site 460265004315 ABC-ATPase subunit interface; other site 460265004316 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 460265004317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265004318 dimer interface [polypeptide binding]; other site 460265004319 conserved gate region; other site 460265004320 putative PBP binding loops; other site 460265004321 ABC-ATPase subunit interface; other site 460265004322 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 460265004323 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 460265004324 Walker A/P-loop; other site 460265004325 ATP binding site [chemical binding]; other site 460265004326 Q-loop/lid; other site 460265004327 ABC transporter signature motif; other site 460265004328 Walker B; other site 460265004329 D-loop; other site 460265004330 H-loop/switch region; other site 460265004331 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 460265004332 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 460265004333 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 460265004334 NAD(P) binding site [chemical binding]; other site 460265004335 benzoate transport; Region: 2A0115; TIGR00895 460265004336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265004337 putative substrate translocation pore; other site 460265004338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265004339 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 460265004340 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 460265004341 carboxyltransferase (CT) interaction site; other site 460265004342 biotinylation site [posttranslational modification]; other site 460265004343 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 460265004344 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 460265004345 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 460265004346 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 460265004347 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 460265004348 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 460265004349 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 460265004350 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 460265004351 carboxyltransferase (CT) interaction site; other site 460265004352 biotinylation site [posttranslational modification]; other site 460265004353 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 460265004354 putative active site [active] 460265004355 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265004356 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265004357 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265004358 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 460265004359 Spore germination protein; Region: Spore_permease; cl17796 460265004360 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 460265004361 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 460265004362 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 460265004363 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 460265004364 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 460265004365 Helix-turn-helix domain; Region: HTH_17; pfam12728 460265004366 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 460265004367 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 460265004368 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 460265004369 active site 460265004370 NTP binding site [chemical binding]; other site 460265004371 active site 460265004372 NTP binding site [chemical binding]; other site 460265004373 nucleic acid binding site [nucleotide binding]; other site 460265004374 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 460265004375 DNA binding site [nucleotide binding] 460265004376 dimer interface [polypeptide binding]; other site 460265004377 active site 460265004378 Int/Topo IB signature motif; other site 460265004379 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 460265004380 GIY-YIG motif/motif A; other site 460265004381 active site 460265004382 catalytic site [active] 460265004383 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 460265004384 active site 460265004385 Methyltransferase domain; Region: Methyltransf_23; pfam13489 460265004386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265004387 S-adenosylmethionine binding site [chemical binding]; other site 460265004388 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 460265004389 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265004390 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265004391 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265004392 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265004393 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265004394 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265004395 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265004396 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265004397 DNA binding residues [nucleotide binding] 460265004398 dimerization interface [polypeptide binding]; other site 460265004399 RyR domain; Region: RyR; pfam02026 460265004400 Autoinducer synthetase; Region: Autoind_synth; cl17404 460265004401 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265004402 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265004403 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265004404 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265004405 transcriptional regulator TraR; Provisional; Region: PRK13870 460265004406 Autoinducer binding domain; Region: Autoind_bind; pfam03472 460265004407 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265004408 DNA binding residues [nucleotide binding] 460265004409 dimerization interface [polypeptide binding]; other site 460265004410 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 460265004411 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265004412 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265004413 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 460265004414 putative dimerization interface [polypeptide binding]; other site 460265004415 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 460265004416 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 460265004417 CsbD-like; Region: CsbD; pfam05532 460265004418 2-isopropylmalate synthase; Validated; Region: PRK00915 460265004419 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 460265004420 active site 460265004421 catalytic residues [active] 460265004422 metal binding site [ion binding]; metal-binding site 460265004423 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 460265004424 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 460265004425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265004426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 460265004427 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 460265004428 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265004429 active site 460265004430 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 460265004431 putative ADP-binding pocket [chemical binding]; other site 460265004432 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265004433 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 460265004434 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 460265004435 Methyltransferase domain; Region: Methyltransf_31; pfam13847 460265004436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265004437 S-adenosylmethionine binding site [chemical binding]; other site 460265004438 camphor resistance protein CrcB; Provisional; Region: PRK14198 460265004439 Rdx family; Region: Rdx; cl01407 460265004440 PAS domain S-box; Region: sensory_box; TIGR00229 460265004441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265004442 putative active site [active] 460265004443 heme pocket [chemical binding]; other site 460265004444 PAS fold; Region: PAS_3; pfam08447 460265004445 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 460265004446 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 460265004447 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 460265004448 active site 460265004449 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 460265004450 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 460265004451 active site 460265004452 catalytic tetrad [active] 460265004453 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265004454 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265004455 putative ligand binding site [chemical binding]; other site 460265004456 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 460265004457 Protein export membrane protein; Region: SecD_SecF; cl14618 460265004458 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 460265004459 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265004460 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265004461 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 460265004462 putative active site pocket [active] 460265004463 cleavage site 460265004464 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 460265004465 PAS domain; Region: PAS_9; pfam13426 460265004466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 460265004467 PAS fold; Region: PAS_3; pfam08447 460265004468 putative active site [active] 460265004469 heme pocket [chemical binding]; other site 460265004470 response regulator FixJ; Provisional; Region: fixJ; PRK09390 460265004471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265004472 active site 460265004473 phosphorylation site [posttranslational modification] 460265004474 intermolecular recognition site; other site 460265004475 dimerization interface [polypeptide binding]; other site 460265004476 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265004477 DNA binding residues [nucleotide binding] 460265004478 dimerization interface [polypeptide binding]; other site 460265004479 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 460265004480 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 460265004481 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 460265004482 mannonate dehydratase; Provisional; Region: PRK03906 460265004483 mannonate dehydratase; Region: uxuA; TIGR00695 460265004484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265004485 DNA-binding site [nucleotide binding]; DNA binding site 460265004486 Transcriptional regulators [Transcription]; Region: FadR; COG2186 460265004487 FCD domain; Region: FCD; pfam07729 460265004488 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 460265004489 DctM-like transporters; Region: DctM; pfam06808 460265004490 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 460265004491 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 460265004492 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 460265004493 putative oxidoreductase; Provisional; Region: PRK10083 460265004494 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 460265004495 putative NAD(P) binding site [chemical binding]; other site 460265004496 catalytic Zn binding site [ion binding]; other site 460265004497 structural Zn binding site [ion binding]; other site 460265004498 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 460265004499 active site 460265004500 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 460265004501 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 460265004502 inhibitor-cofactor binding pocket; inhibition site 460265004503 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265004504 catalytic residue [active] 460265004505 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265004506 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 460265004507 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 460265004508 extended (e) SDRs; Region: SDR_e; cd08946 460265004509 NAD(P) binding site [chemical binding]; other site 460265004510 active site 460265004511 substrate binding site [chemical binding]; other site 460265004512 preprotein translocase subunit SecB; Validated; Region: PRK05751 460265004513 SecA binding site; other site 460265004514 Preprotein binding site; other site 460265004515 Tim44-like domain; Region: Tim44; pfam04280 460265004516 MltA specific insert domain; Region: MltA; smart00925 460265004517 3D domain; Region: 3D; pfam06725 460265004518 Smr domain; Region: Smr; pfam01713 460265004519 transcription termination factor Rho; Provisional; Region: rho; PRK09376 460265004520 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 460265004521 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 460265004522 RNA binding site [nucleotide binding]; other site 460265004523 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 460265004524 multimer interface [polypeptide binding]; other site 460265004525 Walker A motif; other site 460265004526 ATP binding site [chemical binding]; other site 460265004527 Walker B motif; other site 460265004528 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 460265004529 Autoinducer binding domain; Region: Autoind_bind; pfam03472 460265004530 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265004531 DNA binding residues [nucleotide binding] 460265004532 dimerization interface [polypeptide binding]; other site 460265004533 MoxR-like ATPases [General function prediction only]; Region: COG0714 460265004534 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 460265004535 Protein of unknown function DUF58; Region: DUF58; pfam01882 460265004536 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 460265004537 metal ion-dependent adhesion site (MIDAS); other site 460265004538 von Willebrand factor type A domain; Region: VWA_2; pfam13519 460265004539 metal ion-dependent adhesion site (MIDAS); other site 460265004540 Oxygen tolerance; Region: BatD; pfam13584 460265004541 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 460265004542 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 460265004543 putative deacylase active site [active] 460265004544 pantoate--beta-alanine ligase; Region: panC; TIGR00018 460265004545 Pantoate-beta-alanine ligase; Region: PanC; cd00560 460265004546 active site 460265004547 ATP-binding site [chemical binding]; other site 460265004548 pantoate-binding site; other site 460265004549 HXXH motif; other site 460265004550 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 460265004551 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 460265004552 trimer interface [polypeptide binding]; other site 460265004553 active site 460265004554 substrate binding site [chemical binding]; other site 460265004555 CoA binding site [chemical binding]; other site 460265004556 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265004557 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265004558 ligand binding site [chemical binding]; other site 460265004559 flexible hinge region; other site 460265004560 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 460265004561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265004562 active site 460265004563 phosphorylation site [posttranslational modification] 460265004564 intermolecular recognition site; other site 460265004565 dimerization interface [polypeptide binding]; other site 460265004566 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265004567 DNA binding site [nucleotide binding] 460265004568 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 460265004569 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 460265004570 active site 460265004571 catalytic site [active] 460265004572 substrate binding site [chemical binding]; other site 460265004573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 460265004574 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 460265004575 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 460265004576 catalytic residue [active] 460265004577 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 460265004578 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 460265004579 HIGH motif; other site 460265004580 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 460265004581 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 460265004582 active site 460265004583 KMSKS motif; other site 460265004584 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 460265004585 tRNA binding surface [nucleotide binding]; other site 460265004586 Lipopolysaccharide-assembly; Region: LptE; cl01125 460265004587 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 460265004588 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 460265004589 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 460265004590 ParB-like nuclease domain; Region: ParB; smart00470 460265004591 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 460265004592 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 460265004593 P-loop; other site 460265004594 Magnesium ion binding site [ion binding]; other site 460265004595 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 460265004596 Magnesium ion binding site [ion binding]; other site 460265004597 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 460265004598 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 460265004599 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 460265004600 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 460265004601 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 460265004602 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 460265004603 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 460265004604 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 460265004605 trmE is a tRNA modification GTPase; Region: trmE; cd04164 460265004606 G1 box; other site 460265004607 GTP/Mg2+ binding site [chemical binding]; other site 460265004608 Switch I region; other site 460265004609 G2 box; other site 460265004610 Switch II region; other site 460265004611 G3 box; other site 460265004612 G4 box; other site 460265004613 G5 box; other site 460265004614 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 460265004615 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 460265004616 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 460265004617 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 460265004618 catalytic residue [active] 460265004619 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 460265004620 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265004621 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 460265004622 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265004623 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265004624 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 460265004625 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265004626 catalytic loop [active] 460265004627 iron binding site [ion binding]; other site 460265004628 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 460265004629 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 460265004630 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 460265004631 conserved cys residue [active] 460265004632 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265004633 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 460265004634 classical (c) SDRs; Region: SDR_c; cd05233 460265004635 NAD(P) binding site [chemical binding]; other site 460265004636 active site 460265004637 urocanate hydratase; Provisional; Region: PRK05414 460265004638 N-formylglutamate amidohydrolase; Region: FGase; cl01522 460265004639 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 460265004640 active sites [active] 460265004641 tetramer interface [polypeptide binding]; other site 460265004642 imidazolonepropionase; Validated; Region: PRK09356 460265004643 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 460265004644 active site 460265004645 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 460265004646 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 460265004647 active site 460265004648 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 460265004649 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265004650 DNA-binding site [nucleotide binding]; DNA binding site 460265004651 UTRA domain; Region: UTRA; pfam07702 460265004652 Predicted integral membrane protein [Function unknown]; Region: COG0392 460265004653 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 460265004654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265004655 dimer interface [polypeptide binding]; other site 460265004656 phosphorylation site [posttranslational modification] 460265004657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265004658 ATP binding site [chemical binding]; other site 460265004659 Mg2+ binding site [ion binding]; other site 460265004660 G-X-G motif; other site 460265004661 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 460265004662 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 460265004663 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 460265004664 Ligand Binding Site [chemical binding]; other site 460265004665 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 460265004666 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 460265004667 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 460265004668 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 460265004669 putative NADH binding site [chemical binding]; other site 460265004670 putative active site [active] 460265004671 nudix motif; other site 460265004672 putative metal binding site [ion binding]; other site 460265004673 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 460265004674 HIT family signature motif; other site 460265004675 catalytic residue [active] 460265004676 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 460265004677 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265004678 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265004679 ligand binding site [chemical binding]; other site 460265004680 flexible hinge region; other site 460265004681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265004682 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 460265004683 NAD(P) binding site [chemical binding]; other site 460265004684 active site 460265004685 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 460265004686 PemK-like protein; Region: PemK; pfam02452 460265004687 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 460265004688 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 460265004689 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 460265004690 Walker A/P-loop; other site 460265004691 ATP binding site [chemical binding]; other site 460265004692 Q-loop/lid; other site 460265004693 ABC transporter signature motif; other site 460265004694 Walker B; other site 460265004695 D-loop; other site 460265004696 H-loop/switch region; other site 460265004697 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 460265004698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265004699 dimer interface [polypeptide binding]; other site 460265004700 conserved gate region; other site 460265004701 putative PBP binding loops; other site 460265004702 ABC-ATPase subunit interface; other site 460265004703 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 460265004704 NMT1/THI5 like; Region: NMT1; pfam09084 460265004705 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 460265004706 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 460265004707 pyridoxamine kinase; Validated; Region: PRK05756 460265004708 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 460265004709 dimer interface [polypeptide binding]; other site 460265004710 pyridoxal binding site [chemical binding]; other site 460265004711 ATP binding site [chemical binding]; other site 460265004712 tellurite resistance protein terB; Region: terB; cd07176 460265004713 putative metal binding site [ion binding]; other site 460265004714 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 460265004715 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 460265004716 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 460265004717 methionine sulfoxide reductase B; Provisional; Region: PRK00222 460265004718 SelR domain; Region: SelR; pfam01641 460265004719 Protein of unknown function (DUF2385); Region: DUF2385; pfam09539 460265004720 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 460265004721 nudix motif; other site 460265004722 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 460265004723 classical (c) SDRs; Region: SDR_c; cd05233 460265004724 NAD(P) binding site [chemical binding]; other site 460265004725 active site 460265004726 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 460265004727 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 460265004728 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 460265004729 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 460265004730 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 460265004731 chaperone protein DnaJ; Provisional; Region: PRK14299 460265004732 HSP70 interaction site [polypeptide binding]; other site 460265004733 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 460265004734 substrate binding site [polypeptide binding]; other site 460265004735 dimer interface [polypeptide binding]; other site 460265004736 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 460265004737 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 460265004738 Amino acid synthesis; Region: AA_synth; pfam06684 460265004739 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 460265004740 ApbE family; Region: ApbE; pfam02424 460265004741 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 460265004742 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 460265004743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 460265004744 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 460265004745 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 460265004746 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 460265004747 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 460265004748 N-terminal plug; other site 460265004749 ligand-binding site [chemical binding]; other site 460265004750 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 460265004751 Sel1 repeat; Region: Sel1; cl02723 460265004752 Sel1-like repeats; Region: SEL1; smart00671 460265004753 Sel1-like repeats; Region: SEL1; smart00671 460265004754 Sel1-like repeats; Region: SEL1; smart00671 460265004755 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 460265004756 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 460265004757 RNA binding surface [nucleotide binding]; other site 460265004758 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 460265004759 active site 460265004760 uracil binding [chemical binding]; other site 460265004761 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 460265004762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265004763 S-adenosylmethionine binding site [chemical binding]; other site 460265004764 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 460265004765 active site 460265004766 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 460265004767 membrane ATPase/protein kinase; Provisional; Region: PRK09435 460265004768 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 460265004769 Walker A; other site 460265004770 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 460265004771 catalytic core [active] 460265004772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265004773 S-adenosylmethionine binding site [chemical binding]; other site 460265004774 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 460265004775 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 460265004776 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 460265004777 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 460265004778 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 460265004779 UreF; Region: UreF; pfam01730 460265004780 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 460265004781 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 460265004782 dimer interface [polypeptide binding]; other site 460265004783 catalytic residues [active] 460265004784 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 460265004785 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 460265004786 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 460265004787 putative DNA binding site [nucleotide binding]; other site 460265004788 putative Zn2+ binding site [ion binding]; other site 460265004789 AsnC family; Region: AsnC_trans_reg; pfam01037 460265004790 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265004791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265004792 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 460265004793 dimerization interface [polypeptide binding]; other site 460265004794 hypothetical protein; Provisional; Region: PRK05463 460265004795 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265004796 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 460265004797 putative ligand binding site [chemical binding]; other site 460265004798 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 460265004799 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265004800 TM-ABC transporter signature motif; other site 460265004801 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265004802 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265004803 TM-ABC transporter signature motif; other site 460265004804 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265004805 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265004806 Walker A/P-loop; other site 460265004807 ATP binding site [chemical binding]; other site 460265004808 Q-loop/lid; other site 460265004809 ABC transporter signature motif; other site 460265004810 Walker B; other site 460265004811 D-loop; other site 460265004812 H-loop/switch region; other site 460265004813 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265004814 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265004815 Walker A/P-loop; other site 460265004816 ATP binding site [chemical binding]; other site 460265004817 Q-loop/lid; other site 460265004818 ABC transporter signature motif; other site 460265004819 Walker B; other site 460265004820 D-loop; other site 460265004821 H-loop/switch region; other site 460265004822 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 460265004823 putative active site [active] 460265004824 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 460265004825 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 460265004826 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 460265004827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265004828 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 460265004829 putative substrate translocation pore; other site 460265004830 Predicted membrane protein [Function unknown]; Region: COG2259 460265004831 DHHW protein; Region: DHHW; pfam14286 460265004832 PAS domain S-box; Region: sensory_box; TIGR00229 460265004833 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265004834 heme pocket [chemical binding]; other site 460265004835 putative active site [active] 460265004836 PAS domain; Region: PAS_9; pfam13426 460265004837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265004838 putative active site [active] 460265004839 heme pocket [chemical binding]; other site 460265004840 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265004841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265004842 active site 460265004843 phosphorylation site [posttranslational modification] 460265004844 intermolecular recognition site; other site 460265004845 dimerization interface [polypeptide binding]; other site 460265004846 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265004847 DNA binding residues [nucleotide binding] 460265004848 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 460265004849 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 460265004850 active site 460265004851 putative substrate binding pocket [chemical binding]; other site 460265004852 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 460265004853 nudix motif; other site 460265004854 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 460265004855 MarR family; Region: MarR; pfam01047 460265004856 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 460265004857 NlpC/P60 family; Region: NLPC_P60; pfam00877 460265004858 AzlC protein; Region: AzlC; cl00570 460265004859 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 460265004860 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 460265004861 C factor cell-cell signaling protein; Provisional; Region: PRK09009 460265004862 NADP binding site [chemical binding]; other site 460265004863 homodimer interface [polypeptide binding]; other site 460265004864 active site 460265004865 Predicted ATPase [General function prediction only]; Region: COG1485 460265004866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265004867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265004868 malate dehydrogenase; Reviewed; Region: PRK06223 460265004869 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 460265004870 NAD(P) binding site [chemical binding]; other site 460265004871 dimer interface [polypeptide binding]; other site 460265004872 tetramer (dimer of dimers) interface [polypeptide binding]; other site 460265004873 substrate binding site [chemical binding]; other site 460265004874 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 460265004875 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 460265004876 CoA-ligase; Region: Ligase_CoA; pfam00549 460265004877 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 460265004878 CoA binding domain; Region: CoA_binding; smart00881 460265004879 CoA-ligase; Region: Ligase_CoA; pfam00549 460265004880 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 460265004881 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 460265004882 TPP-binding site [chemical binding]; other site 460265004883 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 460265004884 PYR/PP interface [polypeptide binding]; other site 460265004885 dimer interface [polypeptide binding]; other site 460265004886 TPP binding site [chemical binding]; other site 460265004887 YCII-related domain; Region: YCII; pfam03795 460265004888 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 460265004889 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 460265004890 E3 interaction surface; other site 460265004891 lipoyl attachment site [posttranslational modification]; other site 460265004892 e3 binding domain; Region: E3_binding; pfam02817 460265004893 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 460265004894 short chain dehydrogenase; Provisional; Region: PRK06123 460265004895 classical (c) SDRs; Region: SDR_c; cd05233 460265004896 NAD(P) binding site [chemical binding]; other site 460265004897 active site 460265004898 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115 460265004899 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 460265004900 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 460265004901 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 460265004902 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 460265004903 active site 460265004904 dimer interface [polypeptide binding]; other site 460265004905 metal binding site [ion binding]; metal-binding site 460265004906 shikimate kinase; Provisional; Region: PRK13946 460265004907 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 460265004908 ADP binding site [chemical binding]; other site 460265004909 magnesium binding site [ion binding]; other site 460265004910 putative shikimate binding site; other site 460265004911 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 460265004912 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 460265004913 active site 460265004914 DNA binding site [nucleotide binding] 460265004915 Int/Topo IB signature motif; other site 460265004916 Opioid growth factor receptor (OGFr) conserved region; Region: OGFr_N; pfam04664 460265004917 EVE domain; Region: EVE; pfam01878 460265004918 PRC-barrel domain; Region: PRC; pfam05239 460265004919 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 460265004920 methionine sulfoxide reductase A; Provisional; Region: PRK00058 460265004921 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 460265004922 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 460265004923 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 460265004924 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 460265004925 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 460265004926 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 460265004927 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 460265004928 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 460265004929 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 460265004930 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 460265004931 Walker A/P-loop; other site 460265004932 ATP binding site [chemical binding]; other site 460265004933 Q-loop/lid; other site 460265004934 ABC transporter signature motif; other site 460265004935 Walker B; other site 460265004936 D-loop; other site 460265004937 H-loop/switch region; other site 460265004938 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 460265004939 dimer interface [polypeptide binding]; other site 460265004940 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 460265004941 PII uridylyl-transferase; Provisional; Region: PRK05092 460265004942 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 460265004943 metal binding triad; other site 460265004944 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 460265004945 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 460265004946 Zn2+ binding site [ion binding]; other site 460265004947 Mg2+ binding site [ion binding]; other site 460265004948 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 460265004949 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 460265004950 OsmC-like protein; Region: OsmC; pfam02566 460265004951 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 460265004952 30S subunit binding site; other site 460265004953 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 460265004954 active site 460265004955 phosphorylation site [posttranslational modification] 460265004956 Uncharacterized conserved protein [Function unknown]; Region: COG1434 460265004957 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 460265004958 putative active site [active] 460265004959 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 460265004960 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 460265004961 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 460265004962 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 460265004963 Walker A/P-loop; other site 460265004964 ATP binding site [chemical binding]; other site 460265004965 Q-loop/lid; other site 460265004966 ABC transporter signature motif; other site 460265004967 Walker B; other site 460265004968 D-loop; other site 460265004969 H-loop/switch region; other site 460265004970 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 460265004971 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 460265004972 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 460265004973 active site 460265004974 Response regulator receiver domain; Region: Response_reg; pfam00072 460265004975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265004976 active site 460265004977 phosphorylation site [posttranslational modification] 460265004978 intermolecular recognition site; other site 460265004979 dimerization interface [polypeptide binding]; other site 460265004980 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 460265004981 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 460265004982 active site 460265004983 acyl-activating enzyme (AAE) consensus motif; other site 460265004984 putative CoA binding site [chemical binding]; other site 460265004985 AMP binding site [chemical binding]; other site 460265004986 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 460265004987 putative FMN binding site [chemical binding]; other site 460265004988 enoyl-CoA hydratase; Provisional; Region: PRK06144 460265004989 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265004990 substrate binding site [chemical binding]; other site 460265004991 oxyanion hole (OAH) forming residues; other site 460265004992 trimer interface [polypeptide binding]; other site 460265004993 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265004994 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265004995 Walker A/P-loop; other site 460265004996 ATP binding site [chemical binding]; other site 460265004997 Q-loop/lid; other site 460265004998 ABC transporter signature motif; other site 460265004999 Walker B; other site 460265005000 D-loop; other site 460265005001 H-loop/switch region; other site 460265005002 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265005003 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265005004 TM-ABC transporter signature motif; other site 460265005005 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265005006 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265005007 Walker A/P-loop; other site 460265005008 ATP binding site [chemical binding]; other site 460265005009 Q-loop/lid; other site 460265005010 ABC transporter signature motif; other site 460265005011 Walker B; other site 460265005012 D-loop; other site 460265005013 H-loop/switch region; other site 460265005014 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 460265005015 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265005016 TM-ABC transporter signature motif; other site 460265005017 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265005018 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 460265005019 putative ligand binding site [chemical binding]; other site 460265005020 OsmC-like protein; Region: OsmC; cl00767 460265005021 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 460265005022 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 460265005023 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 460265005024 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 460265005025 catalytic residue [active] 460265005026 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 460265005027 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 460265005028 active site 460265005029 dimer interface [polypeptide binding]; other site 460265005030 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 460265005031 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 460265005032 active site 460265005033 FMN binding site [chemical binding]; other site 460265005034 substrate binding site [chemical binding]; other site 460265005035 3Fe-4S cluster binding site [ion binding]; other site 460265005036 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 460265005037 domain interface; other site 460265005038 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 460265005039 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 460265005040 putative C-terminal domain interface [polypeptide binding]; other site 460265005041 putative GSH binding site (G-site) [chemical binding]; other site 460265005042 putative dimer interface [polypeptide binding]; other site 460265005043 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 460265005044 N-terminal domain interface [polypeptide binding]; other site 460265005045 dimer interface [polypeptide binding]; other site 460265005046 substrate binding pocket (H-site) [chemical binding]; other site 460265005047 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 460265005048 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 460265005049 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 460265005050 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 460265005051 active site 460265005052 catalytic triad [active] 460265005053 oxyanion hole [active] 460265005054 Transglycosylase SLT domain; Region: SLT_2; pfam13406 460265005055 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265005056 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265005057 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 460265005058 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 460265005059 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 460265005060 NAD binding site [chemical binding]; other site 460265005061 homodimer interface [polypeptide binding]; other site 460265005062 active site 460265005063 substrate binding site [chemical binding]; other site 460265005064 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 460265005065 active site 460265005066 tetramer interface; other site 460265005067 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 460265005068 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 460265005069 classical (c) SDRs; Region: SDR_c; cd05233 460265005070 NAD(P) binding site [chemical binding]; other site 460265005071 active site 460265005072 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265005073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265005074 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265005075 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 460265005076 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 460265005077 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 460265005078 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 460265005079 active site 460265005080 substrate binding site [chemical binding]; other site 460265005081 metal binding site [ion binding]; metal-binding site 460265005082 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 460265005083 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 460265005084 Substrate binding site; other site 460265005085 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 460265005086 Domain of unknown function (DUF305); Region: DUF305; pfam03713 460265005087 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 460265005088 Cytochrome P450; Region: p450; cl12078 460265005089 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265005090 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265005091 putative ligand binding site [chemical binding]; other site 460265005092 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 460265005093 maleylacetoacetate isomerase; Region: maiA; TIGR01262 460265005094 C-terminal domain interface [polypeptide binding]; other site 460265005095 GSH binding site (G-site) [chemical binding]; other site 460265005096 putative dimer interface [polypeptide binding]; other site 460265005097 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 460265005098 dimer interface [polypeptide binding]; other site 460265005099 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 460265005100 N-terminal domain interface [polypeptide binding]; other site 460265005101 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 460265005102 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 460265005103 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 460265005104 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 460265005105 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265005106 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265005107 putative ligand binding site [chemical binding]; other site 460265005108 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 460265005109 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 460265005110 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 460265005111 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 460265005112 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 460265005113 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 460265005114 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 460265005115 homotrimer interaction site [polypeptide binding]; other site 460265005116 putative active site [active] 460265005117 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265005118 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 460265005119 acyl-activating enzyme (AAE) consensus motif; other site 460265005120 AMP binding site [chemical binding]; other site 460265005121 active site 460265005122 CoA binding site [chemical binding]; other site 460265005123 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 460265005124 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 460265005125 active site 460265005126 FMN binding site [chemical binding]; other site 460265005127 substrate binding site [chemical binding]; other site 460265005128 homotetramer interface [polypeptide binding]; other site 460265005129 catalytic residue [active] 460265005130 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 460265005131 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 460265005132 active site 460265005133 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 460265005134 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265005135 substrate binding site [chemical binding]; other site 460265005136 oxyanion hole (OAH) forming residues; other site 460265005137 trimer interface [polypeptide binding]; other site 460265005138 classical (c) SDRs; Region: SDR_c; cd05233 460265005139 NAD(P) binding site [chemical binding]; other site 460265005140 active site 460265005141 hypothetical protein; Provisional; Region: PRK07538 460265005142 hypothetical protein; Provisional; Region: PRK07236 460265005143 Cupin domain; Region: Cupin_2; pfam07883 460265005144 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265005145 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265005146 Walker A/P-loop; other site 460265005147 ATP binding site [chemical binding]; other site 460265005148 Q-loop/lid; other site 460265005149 ABC transporter signature motif; other site 460265005150 Walker B; other site 460265005151 D-loop; other site 460265005152 H-loop/switch region; other site 460265005153 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265005154 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265005155 Walker A/P-loop; other site 460265005156 ATP binding site [chemical binding]; other site 460265005157 Q-loop/lid; other site 460265005158 ABC transporter signature motif; other site 460265005159 Walker B; other site 460265005160 D-loop; other site 460265005161 H-loop/switch region; other site 460265005162 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265005163 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265005164 TM-ABC transporter signature motif; other site 460265005165 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265005166 TM-ABC transporter signature motif; other site 460265005167 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265005168 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 460265005169 putative ligand binding site [chemical binding]; other site 460265005170 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 460265005171 MarR family; Region: MarR; pfam01047 460265005172 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 460265005173 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 460265005174 putative DNA binding site [nucleotide binding]; other site 460265005175 putative Zn2+ binding site [ion binding]; other site 460265005176 AsnC family; Region: AsnC_trans_reg; pfam01037 460265005177 agmatinase; Region: agmatinase; TIGR01230 460265005178 Arginase family; Region: Arginase; cd09989 460265005179 active site 460265005180 Mn binding site [ion binding]; other site 460265005181 oligomer interface [polypeptide binding]; other site 460265005182 ornithine cyclodeaminase; Validated; Region: PRK07589 460265005183 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 460265005184 RNA polymerase sigma factor; Provisional; Region: PRK12547 460265005185 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265005186 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 460265005187 DNA binding residues [nucleotide binding] 460265005188 LemA family; Region: LemA; pfam04011 460265005189 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 460265005190 Repair protein; Region: Repair_PSII; pfam04536 460265005191 Repair protein; Region: Repair_PSII; cl01535 460265005192 hypothetical protein; Validated; Region: PRK06201 460265005193 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 460265005194 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 460265005195 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 460265005196 Cu(I) binding site [ion binding]; other site 460265005197 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 460265005198 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 460265005199 TLC ATP/ADP transporter; Region: TLC; cl03940 460265005200 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 460265005201 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 460265005202 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 460265005203 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 460265005204 active site 460265005205 catalytic tetrad [active] 460265005206 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 460265005207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265005208 NAD(P) binding site [chemical binding]; other site 460265005209 active site 460265005210 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265005211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265005212 DNA-binding site [nucleotide binding]; DNA binding site 460265005213 FCD domain; Region: FCD; pfam07729 460265005214 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 460265005215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265005216 putative substrate translocation pore; other site 460265005217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 460265005218 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 460265005219 tyrosine decarboxylase; Region: PLN02880 460265005220 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 460265005221 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 460265005222 catalytic residue [active] 460265005223 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 460265005224 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 460265005225 N- and C-terminal domain interface [polypeptide binding]; other site 460265005226 active site 460265005227 MgATP binding site [chemical binding]; other site 460265005228 catalytic site [active] 460265005229 metal binding site [ion binding]; metal-binding site 460265005230 glycerol binding site [chemical binding]; other site 460265005231 homotetramer interface [polypeptide binding]; other site 460265005232 homodimer interface [polypeptide binding]; other site 460265005233 FBP binding site [chemical binding]; other site 460265005234 protein IIAGlc interface [polypeptide binding]; other site 460265005235 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 460265005236 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265005237 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 460265005238 putative ligand binding site [chemical binding]; other site 460265005239 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265005240 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 460265005241 TM-ABC transporter signature motif; other site 460265005242 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265005243 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265005244 TM-ABC transporter signature motif; other site 460265005245 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265005246 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265005247 Walker A/P-loop; other site 460265005248 ATP binding site [chemical binding]; other site 460265005249 Q-loop/lid; other site 460265005250 ABC transporter signature motif; other site 460265005251 Walker B; other site 460265005252 D-loop; other site 460265005253 H-loop/switch region; other site 460265005254 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265005255 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265005256 Walker A/P-loop; other site 460265005257 ATP binding site [chemical binding]; other site 460265005258 Q-loop/lid; other site 460265005259 ABC transporter signature motif; other site 460265005260 Walker B; other site 460265005261 D-loop; other site 460265005262 H-loop/switch region; other site 460265005263 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 460265005264 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 460265005265 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 460265005266 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 460265005267 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 460265005268 NPCBM/NEW2 domain; Region: NPCBM; cl07060 460265005269 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 460265005270 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265005271 catalytic loop [active] 460265005272 iron binding site [ion binding]; other site 460265005273 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 460265005274 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 460265005275 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265005276 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 460265005277 MarR family; Region: MarR_2; cl17246 460265005278 Transcriptional regulators [Transcription]; Region: MarR; COG1846 460265005279 hypothetical protein; Provisional; Region: PRK04334 460265005280 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 460265005281 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 460265005282 putative active site [active] 460265005283 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 460265005284 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 460265005285 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265005286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265005287 dimer interface [polypeptide binding]; other site 460265005288 phosphorylation site [posttranslational modification] 460265005289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265005290 ATP binding site [chemical binding]; other site 460265005291 Mg2+ binding site [ion binding]; other site 460265005292 G-X-G motif; other site 460265005293 osmolarity response regulator; Provisional; Region: ompR; PRK09468 460265005294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265005295 active site 460265005296 phosphorylation site [posttranslational modification] 460265005297 intermolecular recognition site; other site 460265005298 dimerization interface [polypeptide binding]; other site 460265005299 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265005300 DNA binding site [nucleotide binding] 460265005301 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 460265005302 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 460265005303 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 460265005304 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 460265005305 substrate binding site [chemical binding]; other site 460265005306 ATP binding site [chemical binding]; other site 460265005307 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 460265005308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265005309 dimer interface [polypeptide binding]; other site 460265005310 conserved gate region; other site 460265005311 putative PBP binding loops; other site 460265005312 ABC-ATPase subunit interface; other site 460265005313 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 460265005314 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 460265005315 Walker A/P-loop; other site 460265005316 ATP binding site [chemical binding]; other site 460265005317 Q-loop/lid; other site 460265005318 ABC transporter signature motif; other site 460265005319 Walker B; other site 460265005320 D-loop; other site 460265005321 H-loop/switch region; other site 460265005322 TOBE domain; Region: TOBE_2; pfam08402 460265005323 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 460265005324 CoA-transferase family III; Region: CoA_transf_3; pfam02515 460265005325 thiamine pyrophosphate protein; Validated; Region: PRK08199 460265005326 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 460265005327 PYR/PP interface [polypeptide binding]; other site 460265005328 dimer interface [polypeptide binding]; other site 460265005329 TPP binding site [chemical binding]; other site 460265005330 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 460265005331 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 460265005332 TPP-binding site [chemical binding]; other site 460265005333 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 460265005334 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 460265005335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 460265005336 dimer interface [polypeptide binding]; other site 460265005337 ABC-ATPase subunit interface; other site 460265005338 putative PBP binding loops; other site 460265005339 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 460265005340 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 460265005341 FAD binding site [chemical binding]; other site 460265005342 substrate binding pocket [chemical binding]; other site 460265005343 catalytic base [active] 460265005344 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 460265005345 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 460265005346 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 460265005347 substrate binding site [chemical binding]; other site 460265005348 active site 460265005349 PEP synthetase regulatory protein; Provisional; Region: PRK05339 460265005350 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 460265005351 putative active site [active] 460265005352 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 460265005353 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 460265005354 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 460265005355 NAD(P) binding site [chemical binding]; other site 460265005356 shikimate binding site; other site 460265005357 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 460265005358 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 460265005359 CoA-binding site [chemical binding]; other site 460265005360 ATP-binding [chemical binding]; other site 460265005361 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 460265005362 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 460265005363 active site 460265005364 catalytic site [active] 460265005365 substrate binding site [chemical binding]; other site 460265005366 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 460265005367 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 460265005368 active site 460265005369 benzoate transport; Region: 2A0115; TIGR00895 460265005370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265005371 putative substrate translocation pore; other site 460265005372 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265005373 Ribosomal L18 C-terminal region; Region: Ribosomal_L18_c; pfam14204 460265005374 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 460265005375 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 460265005376 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 460265005377 motif II; other site 460265005378 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 460265005379 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 460265005380 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 460265005381 Chromate transporter; Region: Chromate_transp; pfam02417 460265005382 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 460265005383 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 460265005384 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 460265005385 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 460265005386 active site 460265005387 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 460265005388 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 460265005389 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 460265005390 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 460265005391 GMP synthase; Reviewed; Region: guaA; PRK00074 460265005392 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 460265005393 AMP/PPi binding site [chemical binding]; other site 460265005394 candidate oxyanion hole; other site 460265005395 catalytic triad [active] 460265005396 potential glutamine specificity residues [chemical binding]; other site 460265005397 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 460265005398 ATP Binding subdomain [chemical binding]; other site 460265005399 Ligand Binding sites [chemical binding]; other site 460265005400 Dimerization subdomain; other site 460265005401 phosphoglycolate phosphatase; Provisional; Region: PRK13222 460265005402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 460265005403 motif II; other site 460265005404 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 460265005405 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 460265005406 putative acyl-acceptor binding pocket; other site 460265005407 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 460265005408 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 460265005409 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 460265005410 N-terminal plug; other site 460265005411 ligand-binding site [chemical binding]; other site 460265005412 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 460265005413 Cytochrome c; Region: Cytochrom_C; pfam00034 460265005414 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 460265005415 Ligand Binding Site [chemical binding]; other site 460265005416 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 460265005417 dimerization interface [polypeptide binding]; other site 460265005418 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265005419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265005420 ATP binding site [chemical binding]; other site 460265005421 Mg2+ binding site [ion binding]; other site 460265005422 G-X-G motif; other site 460265005423 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 460265005424 cyclase homology domain; Region: CHD; cd07302 460265005425 nucleotidyl binding site; other site 460265005426 metal binding site [ion binding]; metal-binding site 460265005427 dimer interface [polypeptide binding]; other site 460265005428 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 460265005429 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 460265005430 phosphopeptide binding site; other site 460265005431 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 460265005432 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 460265005433 ATP-grasp domain; Region: ATP-grasp_4; cl17255 460265005434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265005435 Major Facilitator Superfamily; Region: MFS_1; pfam07690 460265005436 putative substrate translocation pore; other site 460265005437 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 460265005438 classical (c) SDRs; Region: SDR_c; cd05233 460265005439 NAD(P) binding site [chemical binding]; other site 460265005440 active site 460265005441 Porin subfamily; Region: Porin_2; pfam02530 460265005442 SWI complex, BAF60b domains; Region: SWIB; smart00151 460265005443 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 460265005444 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 460265005445 active site 460265005446 catalytic tetrad [active] 460265005447 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 460265005448 PRC-barrel domain; Region: PRC; pfam05239 460265005449 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 460265005450 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 460265005451 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 460265005452 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 460265005453 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 460265005454 N-terminal plug; other site 460265005455 ligand-binding site [chemical binding]; other site 460265005456 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 460265005457 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 460265005458 intersubunit interface [polypeptide binding]; other site 460265005459 FecCD transport family; Region: FecCD; pfam01032 460265005460 ABC-ATPase subunit interface; other site 460265005461 dimer interface [polypeptide binding]; other site 460265005462 putative PBP binding regions; other site 460265005463 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 460265005464 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 460265005465 Walker A/P-loop; other site 460265005466 ATP binding site [chemical binding]; other site 460265005467 Q-loop/lid; other site 460265005468 ABC transporter signature motif; other site 460265005469 Walker B; other site 460265005470 D-loop; other site 460265005471 H-loop/switch region; other site 460265005472 Caspase domain; Region: Peptidase_C14; pfam00656 460265005473 active site 460265005474 substrate pocket [chemical binding]; other site 460265005475 dimer interface [polypeptide binding]; other site 460265005476 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 460265005477 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265005478 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 460265005479 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 460265005480 Zn2+ binding site [ion binding]; other site 460265005481 Mg2+ binding site [ion binding]; other site 460265005482 Nidogen-like; Region: NIDO; cl02648 460265005483 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 460265005484 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 460265005485 Autotransporter beta-domain; Region: Autotransporter; pfam03797 460265005486 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 460265005487 Catalytic domain of Protein Kinases; Region: PKc; cd00180 460265005488 active site 460265005489 ATP binding site [chemical binding]; other site 460265005490 substrate binding site [chemical binding]; other site 460265005491 activation loop (A-loop); other site 460265005492 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 460265005493 active site 460265005494 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 460265005495 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 460265005496 ligand binding site [chemical binding]; other site 460265005497 Caspase domain; Region: Peptidase_C14; pfam00656 460265005498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265005499 binding surface 460265005500 TPR repeat; Region: TPR_11; pfam13414 460265005501 TPR motif; other site 460265005502 TPR repeat; Region: TPR_11; pfam13414 460265005503 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265005504 TPR motif; other site 460265005505 binding surface 460265005506 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 460265005507 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 460265005508 ligand binding site [chemical binding]; other site 460265005509 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265005510 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 460265005511 39S ribosomal protein L53/MRP-L53; Region: MRP_L53; pfam10780 460265005512 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 460265005513 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 460265005514 putative active site [active] 460265005515 putative active site [active] 460265005516 catalytic site [active] 460265005517 catalytic site [active] 460265005518 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 460265005519 PLD-like domain; Region: PLDc_2; pfam13091 460265005520 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 460265005521 putative active site [active] 460265005522 putative active site [active] 460265005523 catalytic site [active] 460265005524 catalytic site [active] 460265005525 Predicted integral membrane protein [Function unknown]; Region: COG0392 460265005526 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 460265005527 putative catalytic site [active] 460265005528 putative metal binding site [ion binding]; other site 460265005529 putative phosphate binding site [ion binding]; other site 460265005530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265005531 NAD(P) binding site [chemical binding]; other site 460265005532 active site 460265005533 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 460265005534 putative active site [active] 460265005535 putative metal binding site [ion binding]; other site 460265005536 Flagellar protein FlaF; Region: FlaF; cl11454 460265005537 DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120 460265005538 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 460265005539 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265005540 Walker A/P-loop; other site 460265005541 ATP binding site [chemical binding]; other site 460265005542 Q-loop/lid; other site 460265005543 ABC transporter signature motif; other site 460265005544 Walker B; other site 460265005545 D-loop; other site 460265005546 H-loop/switch region; other site 460265005547 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 460265005548 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265005549 Walker A/P-loop; other site 460265005550 ATP binding site [chemical binding]; other site 460265005551 Q-loop/lid; other site 460265005552 ABC transporter signature motif; other site 460265005553 Walker B; other site 460265005554 D-loop; other site 460265005555 H-loop/switch region; other site 460265005556 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 460265005557 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 460265005558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265005559 putative PBP binding loops; other site 460265005560 dimer interface [polypeptide binding]; other site 460265005561 ABC-ATPase subunit interface; other site 460265005562 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 460265005563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265005564 dimer interface [polypeptide binding]; other site 460265005565 conserved gate region; other site 460265005566 putative PBP binding loops; other site 460265005567 ABC-ATPase subunit interface; other site 460265005568 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 460265005569 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 460265005570 peptide binding site [polypeptide binding]; other site 460265005571 dimer interface [polypeptide binding]; other site 460265005572 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 460265005573 amidohydrolase; Region: amidohydrolases; TIGR01891 460265005574 putative metal binding site [ion binding]; other site 460265005575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265005576 Major Facilitator Superfamily; Region: MFS_1; pfam07690 460265005577 putative substrate translocation pore; other site 460265005578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265005579 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 460265005580 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 460265005581 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 460265005582 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 460265005583 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 460265005584 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 460265005585 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265005586 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 460265005587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 460265005588 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 460265005589 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 460265005590 catalytic site [active] 460265005591 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 460265005592 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 460265005593 GAF domain; Region: GAF; pfam01590 460265005594 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 460265005595 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 460265005596 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 460265005597 metal binding site [ion binding]; metal-binding site 460265005598 dimer interface [polypeptide binding]; other site 460265005599 Uncharacterized conserved protein [Function unknown]; Region: COG5476 460265005600 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 460265005601 MlrC C-terminus; Region: MlrC_C; pfam07171 460265005602 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 460265005603 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265005604 acyl-activating enzyme (AAE) consensus motif; other site 460265005605 AMP binding site [chemical binding]; other site 460265005606 active site 460265005607 CoA binding site [chemical binding]; other site 460265005608 Uncharacterized conserved protein [Function unknown]; Region: COG2353 460265005609 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 460265005610 RuvA N terminal domain; Region: RuvA_N; pfam01330 460265005611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265005612 dimer interface [polypeptide binding]; other site 460265005613 phosphorylation site [posttranslational modification] 460265005614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265005615 ATP binding site [chemical binding]; other site 460265005616 Mg2+ binding site [ion binding]; other site 460265005617 G-X-G motif; other site 460265005618 osmolarity response regulator; Provisional; Region: ompR; PRK09468 460265005619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265005620 active site 460265005621 phosphorylation site [posttranslational modification] 460265005622 intermolecular recognition site; other site 460265005623 dimerization interface [polypeptide binding]; other site 460265005624 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265005625 DNA binding site [nucleotide binding] 460265005626 Membrane fusogenic activity; Region: BMFP; pfam04380 460265005627 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 460265005628 Transcriptional regulators [Transcription]; Region: FadR; COG2186 460265005629 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265005630 DNA-binding site [nucleotide binding]; DNA binding site 460265005631 FCD domain; Region: FCD; pfam07729 460265005632 short chain dehydrogenase; Provisional; Region: PRK06701 460265005633 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 460265005634 NAD binding site [chemical binding]; other site 460265005635 metal binding site [ion binding]; metal-binding site 460265005636 active site 460265005637 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 460265005638 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 460265005639 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 460265005640 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 460265005641 feedback inhibition sensing region; other site 460265005642 homohexameric interface [polypeptide binding]; other site 460265005643 nucleotide binding site [chemical binding]; other site 460265005644 N-acetyl-L-glutamate binding site [chemical binding]; other site 460265005645 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 460265005646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 460265005647 motif II; other site 460265005648 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 460265005649 FOG: WD40 repeat [General function prediction only]; Region: COG2319 460265005650 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 460265005651 structural tetrad; other site 460265005652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265005653 active site 460265005654 phosphorylation site [posttranslational modification] 460265005655 intermolecular recognition site; other site 460265005656 dimerization interface [polypeptide binding]; other site 460265005657 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 460265005658 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 460265005659 nucleotide binding site [chemical binding]; other site 460265005660 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 460265005661 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 460265005662 TolR protein; Region: tolR; TIGR02801 460265005663 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 460265005664 PBP superfamily domain; Region: PBP_like; pfam12727 460265005665 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 460265005666 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 460265005667 ligand binding site [chemical binding]; other site 460265005668 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 460265005669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265005670 malonic semialdehyde reductase; Provisional; Region: PRK10538 460265005671 NAD(P) binding site [chemical binding]; other site 460265005672 active site 460265005673 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 460265005674 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 460265005675 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 460265005676 N-terminal plug; other site 460265005677 ligand-binding site [chemical binding]; other site 460265005678 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 460265005679 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 460265005680 putative active site [active] 460265005681 metal binding site [ion binding]; metal-binding site 460265005682 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 460265005683 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 460265005684 putative ligand binding site [chemical binding]; other site 460265005685 NAD binding site [chemical binding]; other site 460265005686 catalytic site [active] 460265005687 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 460265005688 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 460265005689 Walker A/P-loop; other site 460265005690 ATP binding site [chemical binding]; other site 460265005691 Q-loop/lid; other site 460265005692 ABC transporter signature motif; other site 460265005693 Walker B; other site 460265005694 D-loop; other site 460265005695 H-loop/switch region; other site 460265005696 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 460265005697 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 460265005698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265005699 dimer interface [polypeptide binding]; other site 460265005700 conserved gate region; other site 460265005701 putative PBP binding loops; other site 460265005702 ABC-ATPase subunit interface; other site 460265005703 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 460265005704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265005705 dimer interface [polypeptide binding]; other site 460265005706 conserved gate region; other site 460265005707 putative PBP binding loops; other site 460265005708 ABC-ATPase subunit interface; other site 460265005709 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 460265005710 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 460265005711 substrate binding site [chemical binding]; other site 460265005712 ligand binding site [chemical binding]; other site 460265005713 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265005714 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265005715 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265005716 ligand binding site [chemical binding]; other site 460265005717 flexible hinge region; other site 460265005718 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 460265005719 putative switch regulator; other site 460265005720 non-specific DNA interactions [nucleotide binding]; other site 460265005721 DNA binding site [nucleotide binding] 460265005722 sequence specific DNA binding site [nucleotide binding]; other site 460265005723 putative cAMP binding site [chemical binding]; other site 460265005724 Phasin protein; Region: Phasin_2; pfam09361 460265005725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 460265005726 synthase/transferase; Region: PLN02316 460265005727 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 460265005728 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 460265005729 Proline dehydrogenase; Region: Pro_dh; pfam01619 460265005730 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 460265005731 NAD(P) binding site [chemical binding]; other site 460265005732 catalytic residues [active] 460265005733 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 460265005734 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 460265005735 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 460265005736 putative DNA binding site [nucleotide binding]; other site 460265005737 putative Zn2+ binding site [ion binding]; other site 460265005738 AsnC family; Region: AsnC_trans_reg; pfam01037 460265005739 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265005740 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265005741 DNA-binding site [nucleotide binding]; DNA binding site 460265005742 FCD domain; Region: FCD; pfam07729 460265005743 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 460265005744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265005745 putative substrate translocation pore; other site 460265005746 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 460265005747 tartrate dehydrogenase; Region: TTC; TIGR02089 460265005748 pyruvate kinase; Provisional; Region: PRK06247 460265005749 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 460265005750 domain interfaces; other site 460265005751 active site 460265005752 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 460265005753 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 460265005754 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 460265005755 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 460265005756 dimer interface [polypeptide binding]; other site 460265005757 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265005758 metal binding site [ion binding]; metal-binding site 460265005759 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 460265005760 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 460265005761 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 460265005762 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 460265005763 putative NAD(P) binding site [chemical binding]; other site 460265005764 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 460265005765 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 460265005766 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 460265005767 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 460265005768 CGNR zinc finger; Region: zf-CGNR; pfam11706 460265005769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265005770 putative substrate translocation pore; other site 460265005771 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 460265005772 classical (c) SDRs; Region: SDR_c; cd05233 460265005773 NAD(P) binding site [chemical binding]; other site 460265005774 active site 460265005775 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 460265005776 FAD binding domain; Region: FAD_binding_4; pfam01565 460265005777 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 460265005778 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 460265005779 tetramer interface [polypeptide binding]; other site 460265005780 active site 460265005781 Mg2+/Mn2+ binding site [ion binding]; other site 460265005782 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 460265005783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265005784 putative substrate translocation pore; other site 460265005785 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265005786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265005787 DNA-binding site [nucleotide binding]; DNA binding site 460265005788 FCD domain; Region: FCD; pfam07729 460265005789 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 460265005790 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 460265005791 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 460265005792 inhibitor site; inhibition site 460265005793 active site 460265005794 dimer interface [polypeptide binding]; other site 460265005795 catalytic residue [active] 460265005796 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 460265005797 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 460265005798 active site 460265005799 NAD binding site [chemical binding]; other site 460265005800 metal binding site [ion binding]; metal-binding site 460265005801 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 460265005802 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 460265005803 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 460265005804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265005805 D-galactonate transporter; Region: 2A0114; TIGR00893 460265005806 putative substrate translocation pore; other site 460265005807 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 460265005808 FAD binding domain; Region: FAD_binding_4; pfam01565 460265005809 Transcriptional regulators [Transcription]; Region: FadR; COG2186 460265005810 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265005811 DNA-binding site [nucleotide binding]; DNA binding site 460265005812 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 460265005813 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 460265005814 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939 460265005815 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 460265005816 DNA methylase; Region: N6_N4_Mtase; pfam01555 460265005817 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 460265005818 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 460265005819 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 460265005820 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 460265005821 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 460265005822 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 460265005823 Porin subfamily; Region: Porin_2; pfam02530 460265005824 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 460265005825 ligand binding site [chemical binding]; other site 460265005826 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 460265005827 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265005828 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265005829 catalytic residue [active] 460265005830 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 460265005831 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 460265005832 dimer interface [polypeptide binding]; other site 460265005833 active site 460265005834 catalytic residue [active] 460265005835 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 460265005836 SmpB-tmRNA interface; other site 460265005837 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 460265005838 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 460265005839 ligand binding site [chemical binding]; other site 460265005840 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 460265005841 active site clefts [active] 460265005842 zinc binding site [ion binding]; other site 460265005843 dimer interface [polypeptide binding]; other site 460265005844 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 460265005845 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 460265005846 putative C-terminal domain interface [polypeptide binding]; other site 460265005847 putative GSH binding site (G-site) [chemical binding]; other site 460265005848 putative dimer interface [polypeptide binding]; other site 460265005849 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 460265005850 putative N-terminal domain interface [polypeptide binding]; other site 460265005851 putative dimer interface [polypeptide binding]; other site 460265005852 putative substrate binding pocket (H-site) [chemical binding]; other site 460265005853 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 460265005854 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 460265005855 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 460265005856 Cupin domain; Region: Cupin_2; cl17218 460265005857 Flagellar protein FlbT; Region: FlbT; cl11455 460265005858 Domain of unknown function (DUF892); Region: DUF892; pfam05974 460265005859 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 460265005860 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 460265005861 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 460265005862 Walker A/P-loop; other site 460265005863 ATP binding site [chemical binding]; other site 460265005864 Q-loop/lid; other site 460265005865 ABC transporter signature motif; other site 460265005866 Walker B; other site 460265005867 D-loop; other site 460265005868 H-loop/switch region; other site 460265005869 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 460265005870 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 460265005871 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 460265005872 CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009 460265005873 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 460265005874 Peptidase family M50; Region: Peptidase_M50; pfam02163 460265005875 active site 460265005876 putative substrate binding region [chemical binding]; other site 460265005877 FOG: CBS domain [General function prediction only]; Region: COG0517 460265005878 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 460265005879 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 460265005880 B1 nucleotide binding pocket [chemical binding]; other site 460265005881 B2 nucleotide binding pocket [chemical binding]; other site 460265005882 CAS motifs; other site 460265005883 active site 460265005884 DNA polymerase I; Region: pola; TIGR00593 460265005885 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 460265005886 active site 460265005887 metal binding site 1 [ion binding]; metal-binding site 460265005888 putative 5' ssDNA interaction site; other site 460265005889 metal binding site 3; metal-binding site 460265005890 metal binding site 2 [ion binding]; metal-binding site 460265005891 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 460265005892 putative DNA binding site [nucleotide binding]; other site 460265005893 putative metal binding site [ion binding]; other site 460265005894 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 460265005895 active site 460265005896 substrate binding site [chemical binding]; other site 460265005897 catalytic site [active] 460265005898 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 460265005899 active site 460265005900 DNA binding site [nucleotide binding] 460265005901 catalytic site [active] 460265005902 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 460265005903 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 460265005904 putative active site [active] 460265005905 putative dimer interface [polypeptide binding]; other site 460265005906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265005907 active site 460265005908 phosphorylation site [posttranslational modification] 460265005909 intermolecular recognition site; other site 460265005910 dimerization interface [polypeptide binding]; other site 460265005911 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 460265005912 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 460265005913 active site 460265005914 Zn binding site [ion binding]; other site 460265005915 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265005916 DNA-binding site [nucleotide binding]; DNA binding site 460265005917 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265005918 FCD domain; Region: FCD; pfam07729 460265005919 aldolase II superfamily protein; Provisional; Region: PRK07044 460265005920 intersubunit interface [polypeptide binding]; other site 460265005921 active site 460265005922 Zn2+ binding site [ion binding]; other site 460265005923 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 460265005924 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 460265005925 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 460265005926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265005927 dimer interface [polypeptide binding]; other site 460265005928 conserved gate region; other site 460265005929 putative PBP binding loops; other site 460265005930 ABC-ATPase subunit interface; other site 460265005931 dipeptide transporter; Provisional; Region: PRK10913 460265005932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265005933 dimer interface [polypeptide binding]; other site 460265005934 conserved gate region; other site 460265005935 ABC-ATPase subunit interface; other site 460265005936 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 460265005937 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265005938 Walker A/P-loop; other site 460265005939 ATP binding site [chemical binding]; other site 460265005940 Q-loop/lid; other site 460265005941 ABC transporter signature motif; other site 460265005942 Walker B; other site 460265005943 D-loop; other site 460265005944 H-loop/switch region; other site 460265005945 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 460265005946 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265005947 Walker A/P-loop; other site 460265005948 ATP binding site [chemical binding]; other site 460265005949 Q-loop/lid; other site 460265005950 ABC transporter signature motif; other site 460265005951 Walker B; other site 460265005952 D-loop; other site 460265005953 H-loop/switch region; other site 460265005954 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 460265005955 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 460265005956 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 460265005957 putative ligand binding site [chemical binding]; other site 460265005958 NAD binding site [chemical binding]; other site 460265005959 dimerization interface [polypeptide binding]; other site 460265005960 catalytic site [active] 460265005961 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 460265005962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265005963 S-adenosylmethionine binding site [chemical binding]; other site 460265005964 exopolyphosphatase; Region: exo_poly_only; TIGR03706 460265005965 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 460265005966 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 460265005967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265005968 active site 460265005969 phosphorylation site [posttranslational modification] 460265005970 intermolecular recognition site; other site 460265005971 dimerization interface [polypeptide binding]; other site 460265005972 Major Facilitator Superfamily; Region: MFS_1; pfam07690 460265005973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265005974 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 460265005975 Competence protein; Region: Competence; pfam03772 460265005976 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 460265005977 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 460265005978 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 460265005979 active site 460265005980 HIGH motif; other site 460265005981 nucleotide binding site [chemical binding]; other site 460265005982 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 460265005983 active site 460265005984 KMSKS motif; other site 460265005985 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 460265005986 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 460265005987 dimer interface [polypeptide binding]; other site 460265005988 active site 460265005989 citrylCoA binding site [chemical binding]; other site 460265005990 NADH binding [chemical binding]; other site 460265005991 cationic pore residues; other site 460265005992 oxalacetate/citrate binding site [chemical binding]; other site 460265005993 coenzyme A binding site [chemical binding]; other site 460265005994 catalytic triad [active] 460265005995 Homeodomain-like domain; Region: HTH_23; cl17451 460265005996 Winged helix-turn helix; Region: HTH_29; pfam13551 460265005997 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 460265005998 Integrase core domain; Region: rve; pfam00665 460265005999 Integrase core domain; Region: rve_3; pfam13683 460265006000 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 460265006001 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 460265006002 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 460265006003 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 460265006004 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 460265006005 active site 460265006006 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 460265006007 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 460265006008 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 460265006009 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 460265006010 trimer interface [polypeptide binding]; other site 460265006011 active site 460265006012 UDP-GlcNAc binding site [chemical binding]; other site 460265006013 lipid binding site [chemical binding]; lipid-binding site 460265006014 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 460265006015 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 460265006016 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 460265006017 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 460265006018 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 460265006019 Surface antigen; Region: Bac_surface_Ag; pfam01103 460265006020 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 460265006021 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 460265006022 active site 460265006023 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 460265006024 protein binding site [polypeptide binding]; other site 460265006025 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 460265006026 putative substrate binding region [chemical binding]; other site 460265006027 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 460265006028 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 460265006029 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 460265006030 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 460265006031 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 460265006032 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 460265006033 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 460265006034 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 460265006035 catalytic residue [active] 460265006036 putative FPP diphosphate binding site; other site 460265006037 putative FPP binding hydrophobic cleft; other site 460265006038 dimer interface [polypeptide binding]; other site 460265006039 putative IPP diphosphate binding site; other site 460265006040 ribosome recycling factor; Reviewed; Region: frr; PRK00083 460265006041 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 460265006042 hinge region; other site 460265006043 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 460265006044 putative nucleotide binding site [chemical binding]; other site 460265006045 uridine monophosphate binding site [chemical binding]; other site 460265006046 homohexameric interface [polypeptide binding]; other site 460265006047 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 460265006048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265006049 S-adenosylmethionine binding site [chemical binding]; other site 460265006050 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 460265006051 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 460265006052 DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120 460265006053 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 460265006054 active site 460265006055 DNA binding site [nucleotide binding] 460265006056 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 460265006057 DNA binding site [nucleotide binding] 460265006058 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 460265006059 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265006060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265006061 active site 460265006062 phosphorylation site [posttranslational modification] 460265006063 intermolecular recognition site; other site 460265006064 dimerization interface [polypeptide binding]; other site 460265006065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265006066 DNA binding residues [nucleotide binding] 460265006067 dimerization interface [polypeptide binding]; other site 460265006068 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265006069 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265006070 Walker A/P-loop; other site 460265006071 ATP binding site [chemical binding]; other site 460265006072 Q-loop/lid; other site 460265006073 ABC transporter signature motif; other site 460265006074 Walker B; other site 460265006075 D-loop; other site 460265006076 H-loop/switch region; other site 460265006077 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265006078 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265006079 Walker A/P-loop; other site 460265006080 ATP binding site [chemical binding]; other site 460265006081 Q-loop/lid; other site 460265006082 ABC transporter signature motif; other site 460265006083 Walker B; other site 460265006084 D-loop; other site 460265006085 H-loop/switch region; other site 460265006086 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265006087 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265006088 TM-ABC transporter signature motif; other site 460265006089 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265006090 TM-ABC transporter signature motif; other site 460265006091 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265006092 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 460265006093 ligand binding site [chemical binding]; other site 460265006094 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 460265006095 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 460265006096 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 460265006097 active site 460265006098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265006099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265006100 RNA polymerase sigma factor; Provisional; Region: PRK12547 460265006101 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265006102 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 460265006103 DNA binding residues [nucleotide binding] 460265006104 putative transporter; Provisional; Region: PRK11660 460265006105 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 460265006106 Sulfate transporter family; Region: Sulfate_transp; pfam00916 460265006107 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 460265006108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265006109 non-specific DNA binding site [nucleotide binding]; other site 460265006110 salt bridge; other site 460265006111 sequence-specific DNA binding site [nucleotide binding]; other site 460265006112 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 460265006113 putative active site [active] 460265006114 putative metal binding site [ion binding]; other site 460265006115 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 460265006116 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265006117 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 460265006118 CoenzymeA binding site [chemical binding]; other site 460265006119 subunit interaction site [polypeptide binding]; other site 460265006120 PHB binding site; other site 460265006121 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 460265006122 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 460265006123 active site 460265006124 oxyanion hole [active] 460265006125 psiF repeat; Region: PsiF_repeat; pfam07769 460265006126 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 460265006127 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 460265006128 psiF repeat; Region: PsiF_repeat; pfam07769 460265006129 psiF repeat; Region: PsiF_repeat; pfam07769 460265006130 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 460265006131 Phage Terminase; Region: Terminase_1; pfam03354 460265006132 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 460265006133 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 460265006134 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 460265006135 catalytic residues [active] 460265006136 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 460265006137 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 460265006138 NAD(P) binding site [chemical binding]; other site 460265006139 catalytic residues [active] 460265006140 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 460265006141 Cupin; Region: Cupin_6; pfam12852 460265006142 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 460265006143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265006144 EamA-like transporter family; Region: EamA; pfam00892 460265006145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265006146 S-adenosylmethionine binding site [chemical binding]; other site 460265006147 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 460265006148 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 460265006149 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265006150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265006151 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 460265006152 putative substrate binding pocket [chemical binding]; other site 460265006153 putative dimerization interface [polypeptide binding]; other site 460265006154 potassium uptake protein; Region: kup; TIGR00794 460265006155 K+ potassium transporter; Region: K_trans; pfam02705 460265006156 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 460265006157 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 460265006158 transmembrane helices; other site 460265006159 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 460265006160 TrkA-C domain; Region: TrkA_C; pfam02080 460265006161 TrkA-C domain; Region: TrkA_C; pfam02080 460265006162 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 460265006163 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 460265006164 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 460265006165 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 460265006166 ATP binding site [chemical binding]; other site 460265006167 putative Mg++ binding site [ion binding]; other site 460265006168 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 460265006169 nucleotide binding region [chemical binding]; other site 460265006170 ATP-binding site [chemical binding]; other site 460265006171 TRCF domain; Region: TRCF; pfam03461 460265006172 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 460265006173 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 460265006174 active site 460265006175 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 460265006176 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 460265006177 dimer interface [polypeptide binding]; other site 460265006178 active site 460265006179 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 460265006180 dimer interface [polypeptide binding]; other site 460265006181 active site 460265006182 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 460265006183 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 460265006184 putative active site [active] 460265006185 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 460265006186 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 460265006187 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 460265006188 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 460265006189 homotetramer interface [polypeptide binding]; other site 460265006190 ligand binding site [chemical binding]; other site 460265006191 catalytic site [active] 460265006192 NAD binding site [chemical binding]; other site 460265006193 PAS fold; Region: PAS_7; pfam12860 460265006194 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 460265006195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265006196 dimer interface [polypeptide binding]; other site 460265006197 phosphorylation site [posttranslational modification] 460265006198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265006199 ATP binding site [chemical binding]; other site 460265006200 Mg2+ binding site [ion binding]; other site 460265006201 G-X-G motif; other site 460265006202 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 460265006203 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 460265006204 Phosphotransferase enzyme family; Region: APH; pfam01636 460265006205 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 460265006206 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 460265006207 Substrate binding site; other site 460265006208 metal-binding site 460265006209 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 460265006210 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 460265006211 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 460265006212 Family description; Region: UvrD_C_2; pfam13538 460265006213 Uncharacterized conserved protein [Function unknown]; Region: COG2835 460265006214 primosome assembly protein PriA; Validated; Region: PRK05580 460265006215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 460265006216 ATP binding site [chemical binding]; other site 460265006217 putative Mg++ binding site [ion binding]; other site 460265006218 helicase superfamily c-terminal domain; Region: HELICc; smart00490 460265006219 nucleotide binding region [chemical binding]; other site 460265006220 ATP-binding site [chemical binding]; other site 460265006221 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 460265006222 Isochorismatase family; Region: Isochorismatase; pfam00857 460265006223 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 460265006224 catalytic triad [active] 460265006225 conserved cis-peptide bond; other site 460265006226 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265006227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265006228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265006229 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265006230 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265006231 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 460265006232 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 460265006233 Walker A/P-loop; other site 460265006234 ATP binding site [chemical binding]; other site 460265006235 Q-loop/lid; other site 460265006236 ABC transporter signature motif; other site 460265006237 Walker B; other site 460265006238 D-loop; other site 460265006239 H-loop/switch region; other site 460265006240 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 460265006241 substrate binding site [chemical binding]; other site 460265006242 active site 460265006243 catalytic residues [active] 460265006244 heterodimer interface [polypeptide binding]; other site 460265006245 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 460265006246 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 460265006247 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 460265006248 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 460265006249 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 460265006250 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 460265006251 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 460265006252 catalytic residues [active] 460265006253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265006254 dimer interface [polypeptide binding]; other site 460265006255 phosphorylation site [posttranslational modification] 460265006256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265006257 ATP binding site [chemical binding]; other site 460265006258 Mg2+ binding site [ion binding]; other site 460265006259 G-X-G motif; other site 460265006260 Response regulator receiver domain; Region: Response_reg; pfam00072 460265006261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265006262 active site 460265006263 phosphorylation site [posttranslational modification] 460265006264 intermolecular recognition site; other site 460265006265 dimerization interface [polypeptide binding]; other site 460265006266 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 460265006267 putative DNA binding site [nucleotide binding]; other site 460265006268 dimerization interface [polypeptide binding]; other site 460265006269 Transcriptional regulators [Transcription]; Region: MarR; COG1846 460265006270 putative Zn2+ binding site [ion binding]; other site 460265006271 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14839 460265006272 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 460265006273 catalytic residue [active] 460265006274 putative FPP diphosphate binding site; other site 460265006275 putative FPP binding hydrophobic cleft; other site 460265006276 dimer interface [polypeptide binding]; other site 460265006277 putative IPP diphosphate binding site; other site 460265006278 Transcriptional regulator [Transcription]; Region: IclR; COG1414 460265006279 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 460265006280 Bacterial transcriptional regulator; Region: IclR; pfam01614 460265006281 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 460265006282 salicylate hydroxylase; Provisional; Region: PRK08163 460265006283 Phosphopantetheine attachment site; Region: PP-binding; cl09936 460265006284 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 460265006285 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 460265006286 trimer interface [polypeptide binding]; other site 460265006287 putative metal binding site [ion binding]; other site 460265006288 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 460265006289 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 460265006290 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 460265006291 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 460265006292 active site 460265006293 HIGH motif; other site 460265006294 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 460265006295 KMSKS motif; other site 460265006296 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 460265006297 tRNA binding surface [nucleotide binding]; other site 460265006298 anticodon binding site; other site 460265006299 CreA protein; Region: CreA; pfam05981 460265006300 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 460265006301 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 460265006302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265006303 NAD(P) binding site [chemical binding]; other site 460265006304 active site 460265006305 amidase; Provisional; Region: PRK07042 460265006306 Amidase; Region: Amidase; cl11426 460265006307 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 460265006308 putative active site [active] 460265006309 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 460265006310 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 460265006311 Predicted acetyltransferase [General function prediction only]; Region: COG3153 460265006312 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 460265006313 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 460265006314 dimer interface [polypeptide binding]; other site 460265006315 active site 460265006316 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 460265006317 catalytic residues [active] 460265006318 substrate binding site [chemical binding]; other site 460265006319 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 460265006320 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 460265006321 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 460265006322 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 460265006323 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 460265006324 C-terminal domain interface [polypeptide binding]; other site 460265006325 GSH binding site (G-site) [chemical binding]; other site 460265006326 dimer interface [polypeptide binding]; other site 460265006327 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 460265006328 N-terminal domain interface [polypeptide binding]; other site 460265006329 putative dimer interface [polypeptide binding]; other site 460265006330 active site 460265006331 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 460265006332 ABC-2 type transporter; Region: ABC2_membrane; cl17235 460265006333 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 460265006334 spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886 460265006335 Short C-terminal domain; Region: SHOCT; pfam09851 460265006336 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 460265006337 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 460265006338 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 460265006339 Walker A/P-loop; other site 460265006340 ATP binding site [chemical binding]; other site 460265006341 Q-loop/lid; other site 460265006342 ABC transporter signature motif; other site 460265006343 Walker B; other site 460265006344 D-loop; other site 460265006345 H-loop/switch region; other site 460265006346 Iron permease FTR1 family; Region: FTR1; cl00475 460265006347 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 460265006348 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 460265006349 Imelysin; Region: Peptidase_M75; pfam09375 460265006350 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 460265006351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265006352 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265006353 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265006354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265006355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265006356 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 460265006357 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 460265006358 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265006359 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265006360 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 460265006361 CsbD-like; Region: CsbD; pfam05532 460265006362 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 460265006363 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 460265006364 putative metal binding site [ion binding]; other site 460265006365 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 460265006366 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 460265006367 maltose O-acetyltransferase; Provisional; Region: PRK10092 460265006368 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 460265006369 active site 460265006370 substrate binding site [chemical binding]; other site 460265006371 trimer interface [polypeptide binding]; other site 460265006372 CoA binding site [chemical binding]; other site 460265006373 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 460265006374 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 460265006375 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 460265006376 putative active site [active] 460265006377 catalytic triad [active] 460265006378 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 460265006379 aspartate aminotransferase; Provisional; Region: PRK05764 460265006380 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 460265006381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265006382 homodimer interface [polypeptide binding]; other site 460265006383 catalytic residue [active] 460265006384 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 460265006385 Histidine kinase; Region: HisKA_2; pfam07568 460265006386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265006387 ATP binding site [chemical binding]; other site 460265006388 Mg2+ binding site [ion binding]; other site 460265006389 G-X-G motif; other site 460265006390 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 460265006391 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 460265006392 diaminopimelate decarboxylase; Region: lysA; TIGR01048 460265006393 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 460265006394 active site 460265006395 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 460265006396 substrate binding site [chemical binding]; other site 460265006397 catalytic residues [active] 460265006398 dimer interface [polypeptide binding]; other site 460265006399 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 460265006400 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265006401 dimer interface [polypeptide binding]; other site 460265006402 phosphorylation site [posttranslational modification] 460265006403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265006404 ATP binding site [chemical binding]; other site 460265006405 Mg2+ binding site [ion binding]; other site 460265006406 G-X-G motif; other site 460265006407 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 460265006408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265006409 active site 460265006410 phosphorylation site [posttranslational modification] 460265006411 intermolecular recognition site; other site 460265006412 dimerization interface [polypeptide binding]; other site 460265006413 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 460265006414 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 460265006415 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 460265006416 active site 460265006417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 460265006418 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 460265006419 putative binding surface; other site 460265006420 active site 460265006421 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 460265006422 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 460265006423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265006424 ATP binding site [chemical binding]; other site 460265006425 Mg2+ binding site [ion binding]; other site 460265006426 G-X-G motif; other site 460265006427 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 460265006428 Response regulator receiver domain; Region: Response_reg; pfam00072 460265006429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265006430 active site 460265006431 phosphorylation site [posttranslational modification] 460265006432 intermolecular recognition site; other site 460265006433 dimerization interface [polypeptide binding]; other site 460265006434 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 460265006435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265006436 Response regulator receiver domain; Region: Response_reg; pfam00072 460265006437 active site 460265006438 phosphorylation site [posttranslational modification] 460265006439 intermolecular recognition site; other site 460265006440 dimerization interface [polypeptide binding]; other site 460265006441 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 460265006442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265006443 active site 460265006444 phosphorylation site [posttranslational modification] 460265006445 intermolecular recognition site; other site 460265006446 dimerization interface [polypeptide binding]; other site 460265006447 CheB methylesterase; Region: CheB_methylest; pfam01339 460265006448 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 460265006449 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 460265006450 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 460265006451 elongation factor Ts; Provisional; Region: tsf; PRK09377 460265006452 UBA/TS-N domain; Region: UBA; pfam00627 460265006453 Elongation factor TS; Region: EF_TS; pfam00889 460265006454 Elongation factor TS; Region: EF_TS; pfam00889 460265006455 30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311 460265006456 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 460265006457 rRNA interaction site [nucleotide binding]; other site 460265006458 S8 interaction site; other site 460265006459 putative laminin-1 binding site; other site 460265006460 Uncharacterized conserved protein [Function unknown]; Region: COG3743 460265006461 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 460265006462 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 460265006463 putative C-terminal domain interface [polypeptide binding]; other site 460265006464 putative GSH binding site (G-site) [chemical binding]; other site 460265006465 putative dimer interface [polypeptide binding]; other site 460265006466 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 460265006467 dimer interface [polypeptide binding]; other site 460265006468 N-terminal domain interface [polypeptide binding]; other site 460265006469 putative substrate binding pocket (H-site) [chemical binding]; other site 460265006470 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 460265006471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265006472 putative substrate translocation pore; other site 460265006473 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 460265006474 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 460265006475 Protein of unknown function (DUF992); Region: DUF992; pfam06186 460265006476 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 460265006477 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 460265006478 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 460265006479 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 460265006480 classical (c) SDRs; Region: SDR_c; cd05233 460265006481 NAD(P) binding site [chemical binding]; other site 460265006482 active site 460265006483 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 460265006484 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 460265006485 cyanate hydratase; Validated; Region: PRK02866 460265006486 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 460265006487 oligomer interface [polypeptide binding]; other site 460265006488 active site 460265006489 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 460265006490 Methyltransferase domain; Region: Methyltransf_24; pfam13578 460265006491 Methyltransferase domain; Region: Methyltransf_23; pfam13489 460265006492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265006493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 460265006494 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 460265006495 active site 460265006496 8-oxo-dGMP binding site [chemical binding]; other site 460265006497 nudix motif; other site 460265006498 metal binding site [ion binding]; metal-binding site 460265006499 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 460265006500 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 460265006501 heterotetramer interface [polypeptide binding]; other site 460265006502 active site pocket [active] 460265006503 cleavage site 460265006504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265006505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265006506 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 460265006507 putative effector binding pocket; other site 460265006508 dimerization interface [polypeptide binding]; other site 460265006509 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 460265006510 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 460265006511 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 460265006512 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265006513 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 460265006514 DNA binding residues [nucleotide binding] 460265006515 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 460265006516 Ferredoxin [Energy production and conversion]; Region: COG1146 460265006517 4Fe-4S binding domain; Region: Fer4; cl02805 460265006518 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 460265006519 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 460265006520 RNA binding surface [nucleotide binding]; other site 460265006521 DEAD-like helicases superfamily; Region: DEXDc; smart00487 460265006522 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 460265006523 ATP binding site [chemical binding]; other site 460265006524 putative Mg++ binding site [ion binding]; other site 460265006525 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 460265006526 nucleotide binding region [chemical binding]; other site 460265006527 ATP-binding site [chemical binding]; other site 460265006528 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 460265006529 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 460265006530 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 460265006531 active site 460265006532 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 460265006533 Domain of unknown function DUF20; Region: UPF0118; pfam01594 460265006534 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 460265006535 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 460265006536 active site 460265006537 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 460265006538 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 460265006539 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 460265006540 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 460265006541 putative dimer interface [polypeptide binding]; other site 460265006542 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 460265006543 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 460265006544 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 460265006545 domain interfaces; other site 460265006546 active site 460265006547 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 460265006548 Transglycosylase; Region: Transgly; pfam00912 460265006549 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 460265006550 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 460265006551 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 460265006552 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 460265006553 active site 460265006554 catalytic tetrad [active] 460265006555 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265006556 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265006557 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 460265006558 putative effector binding pocket; other site 460265006559 putative dimerization interface [polypeptide binding]; other site 460265006560 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 460265006561 MG2 domain; Region: A2M_N; pfam01835 460265006562 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 460265006563 surface patch; other site 460265006564 thioester region; other site 460265006565 specificity defining residues; other site 460265006566 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 460265006567 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 460265006568 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 460265006569 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 460265006570 substrate binding site [chemical binding]; other site 460265006571 hexamer interface [polypeptide binding]; other site 460265006572 metal binding site [ion binding]; metal-binding site 460265006573 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 460265006574 rRNA binding site [nucleotide binding]; other site 460265006575 predicted 30S ribosome binding site; other site 460265006576 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 460265006577 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 460265006578 dimerization interface [polypeptide binding]; other site 460265006579 ligand binding site [chemical binding]; other site 460265006580 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265006581 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265006582 Walker A/P-loop; other site 460265006583 ATP binding site [chemical binding]; other site 460265006584 Q-loop/lid; other site 460265006585 ABC transporter signature motif; other site 460265006586 Walker B; other site 460265006587 D-loop; other site 460265006588 H-loop/switch region; other site 460265006589 LysE type translocator; Region: LysE; cl00565 460265006590 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265006591 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265006592 Walker A/P-loop; other site 460265006593 ATP binding site [chemical binding]; other site 460265006594 Q-loop/lid; other site 460265006595 ABC transporter signature motif; other site 460265006596 Walker B; other site 460265006597 D-loop; other site 460265006598 H-loop/switch region; other site 460265006599 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 460265006600 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 460265006601 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265006602 TM-ABC transporter signature motif; other site 460265006603 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 460265006604 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265006605 TM-ABC transporter signature motif; other site 460265006606 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 460265006607 putative hydrophobic ligand binding site [chemical binding]; other site 460265006608 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 460265006609 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 460265006610 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 460265006611 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 460265006612 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265006613 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 460265006614 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 460265006615 MoxR-like ATPases [General function prediction only]; Region: COG0714 460265006616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265006617 Walker A motif; other site 460265006618 ATP binding site [chemical binding]; other site 460265006619 Walker B motif; other site 460265006620 arginine finger; other site 460265006621 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 460265006622 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 460265006623 metal ion-dependent adhesion site (MIDAS); other site 460265006624 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 460265006625 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 460265006626 XdhC Rossmann domain; Region: XdhC_C; pfam13478 460265006627 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 460265006628 putative MPT binding site; other site 460265006629 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 460265006630 Ligand binding site; other site 460265006631 metal-binding site 460265006632 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 460265006633 Usg-like family; Region: Usg; pfam06233 460265006634 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 460265006635 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 460265006636 substrate binding site [chemical binding]; other site 460265006637 active site 460265006638 cosubstrate binding site; other site 460265006639 catalytic site [active] 460265006640 Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911 460265006641 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 460265006642 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 460265006643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265006644 putative substrate translocation pore; other site 460265006645 Autoinducer synthetase; Region: Autoind_synth; cl17404 460265006646 Autoinducer binding domain; Region: Autoind_bind; pfam03472 460265006647 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265006648 DNA binding residues [nucleotide binding] 460265006649 dimerization interface [polypeptide binding]; other site 460265006650 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 460265006651 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 460265006652 ring oligomerisation interface [polypeptide binding]; other site 460265006653 ATP/Mg binding site [chemical binding]; other site 460265006654 stacking interactions; other site 460265006655 hinge regions; other site 460265006656 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 460265006657 oligomerisation interface [polypeptide binding]; other site 460265006658 mobile loop; other site 460265006659 roof hairpin; other site 460265006660 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 460265006661 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 460265006662 peptide binding site [polypeptide binding]; other site 460265006663 HAMP domain; Region: HAMP; pfam00672 460265006664 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 460265006665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265006666 ATP binding site [chemical binding]; other site 460265006667 Mg2+ binding site [ion binding]; other site 460265006668 G-X-G motif; other site 460265006669 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 460265006670 S-formylglutathione hydrolase; Region: PLN02442 460265006671 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 460265006672 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 460265006673 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 460265006674 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 460265006675 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 460265006676 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 460265006677 active site 460265006678 catalytic triad [active] 460265006679 oxyanion hole [active] 460265006680 switch loop; other site 460265006681 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 460265006682 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 460265006683 Walker A/P-loop; other site 460265006684 ATP binding site [chemical binding]; other site 460265006685 Q-loop/lid; other site 460265006686 ABC transporter signature motif; other site 460265006687 Walker B; other site 460265006688 D-loop; other site 460265006689 H-loop/switch region; other site 460265006690 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 460265006691 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 460265006692 FtsX-like permease family; Region: FtsX; pfam02687 460265006693 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 460265006694 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 460265006695 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265006696 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265006697 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 460265006698 catalytic residues [active] 460265006699 dimer interface [polypeptide binding]; other site 460265006700 Domain of unknown function (DUF336); Region: DUF336; cl01249 460265006701 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 460265006702 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 460265006703 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 460265006704 Walker A motif; other site 460265006705 ATP binding site [chemical binding]; other site 460265006706 Walker B motif; other site 460265006707 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 460265006708 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 460265006709 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 460265006710 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 460265006711 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 460265006712 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 460265006713 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 460265006714 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 460265006715 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 460265006716 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 460265006717 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 460265006718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265006719 Walker A/P-loop; other site 460265006720 ATP binding site [chemical binding]; other site 460265006721 Q-loop/lid; other site 460265006722 ABC transporter signature motif; other site 460265006723 Walker B; other site 460265006724 D-loop; other site 460265006725 H-loop/switch region; other site 460265006726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265006727 dimer interface [polypeptide binding]; other site 460265006728 conserved gate region; other site 460265006729 putative PBP binding loops; other site 460265006730 ABC-ATPase subunit interface; other site 460265006731 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 460265006732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265006733 dimer interface [polypeptide binding]; other site 460265006734 conserved gate region; other site 460265006735 putative PBP binding loops; other site 460265006736 ABC-ATPase subunit interface; other site 460265006737 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 460265006738 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 460265006739 CysD dimerization site [polypeptide binding]; other site 460265006740 G1 box; other site 460265006741 putative GEF interaction site [polypeptide binding]; other site 460265006742 GTP/Mg2+ binding site [chemical binding]; other site 460265006743 Switch I region; other site 460265006744 G2 box; other site 460265006745 G3 box; other site 460265006746 Switch II region; other site 460265006747 G4 box; other site 460265006748 G5 box; other site 460265006749 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 460265006750 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 460265006751 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 460265006752 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 460265006753 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 460265006754 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 460265006755 Active Sites [active] 460265006756 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 460265006757 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 460265006758 Active Sites [active] 460265006759 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 460265006760 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 460265006761 putative DNA binding site [nucleotide binding]; other site 460265006762 putative Zn2+ binding site [ion binding]; other site 460265006763 AsnC family; Region: AsnC_trans_reg; pfam01037 460265006764 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 460265006765 Flavodoxin; Region: Flavodoxin_1; pfam00258 460265006766 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 460265006767 FAD binding pocket [chemical binding]; other site 460265006768 FAD binding motif [chemical binding]; other site 460265006769 catalytic residues [active] 460265006770 NAD binding pocket [chemical binding]; other site 460265006771 phosphate binding motif [ion binding]; other site 460265006772 beta-alpha-beta structure motif; other site 460265006773 sulfite reductase subunit beta; Provisional; Region: PRK13504 460265006774 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 460265006775 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 460265006776 aminotransferase; Provisional; Region: PRK13356 460265006777 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 460265006778 homodimer interface [polypeptide binding]; other site 460265006779 substrate-cofactor binding pocket; other site 460265006780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265006781 catalytic residue [active] 460265006782 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 460265006783 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 460265006784 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265006785 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 460265006786 DNA-binding site [nucleotide binding]; DNA binding site 460265006787 RNA-binding motif; other site 460265006788 N-terminal CTNNB1 binding; Region: CTNNB1_binding; pfam08347 460265006789 intracellular protease, PfpI family; Region: PfpI; TIGR01382 460265006790 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 460265006791 proposed catalytic triad [active] 460265006792 conserved cys residue [active] 460265006793 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 460265006794 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 460265006795 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 460265006796 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 460265006797 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 460265006798 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 460265006799 Nitrogen regulatory protein P-II; Region: P-II; smart00938 460265006800 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 460265006801 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 460265006802 active site 460265006803 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 460265006804 catalytic triad [active] 460265006805 dimer interface [polypeptide binding]; other site 460265006806 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 460265006807 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 460265006808 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 460265006809 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 460265006810 Ligand binding site; other site 460265006811 DXD motif; other site 460265006812 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 460265006813 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 460265006814 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 460265006815 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 460265006816 Substrate binding site; other site 460265006817 Mg++ binding site; other site 460265006818 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 460265006819 active site 460265006820 substrate binding site [chemical binding]; other site 460265006821 CoA binding site [chemical binding]; other site 460265006822 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 460265006823 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 460265006824 glutaminase active site [active] 460265006825 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 460265006826 dimer interface [polypeptide binding]; other site 460265006827 active site 460265006828 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 460265006829 dimer interface [polypeptide binding]; other site 460265006830 active site 460265006831 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 460265006832 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 460265006833 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 460265006834 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 460265006835 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 460265006836 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 460265006837 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265006838 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265006839 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265006840 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 460265006841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265006842 active site 460265006843 phosphorylation site [posttranslational modification] 460265006844 intermolecular recognition site; other site 460265006845 dimerization interface [polypeptide binding]; other site 460265006846 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 460265006847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265006848 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265006849 dimer interface [polypeptide binding]; other site 460265006850 phosphorylation site [posttranslational modification] 460265006851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265006852 ATP binding site [chemical binding]; other site 460265006853 Mg2+ binding site [ion binding]; other site 460265006854 G-X-G motif; other site 460265006855 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 460265006856 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 460265006857 Protein of unknown function DUF45; Region: DUF45; pfam01863 460265006858 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 460265006859 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 460265006860 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 460265006861 Probable Catalytic site; other site 460265006862 metal-binding site 460265006863 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 460265006864 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 460265006865 Probable Catalytic site; other site 460265006866 metal-binding site 460265006867 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 460265006868 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 460265006869 ATP binding site [chemical binding]; other site 460265006870 active site 460265006871 substrate binding site [chemical binding]; other site 460265006872 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 460265006873 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 460265006874 putative hydrolase; Provisional; Region: PRK11460 460265006875 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 460265006876 endonuclease III; Region: ENDO3c; smart00478 460265006877 minor groove reading motif; other site 460265006878 helix-hairpin-helix signature motif; other site 460265006879 substrate binding pocket [chemical binding]; other site 460265006880 active site 460265006881 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 460265006882 active site 460265006883 HIGH motif; other site 460265006884 nucleotide binding site [chemical binding]; other site 460265006885 active site 460265006886 KMSKS motif; other site 460265006887 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 460265006888 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 460265006889 conserved cys residue [active] 460265006890 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 460265006891 conserved cys residue [active] 460265006892 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 460265006893 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 460265006894 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 460265006895 active site 460265006896 catalytic site [active] 460265006897 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 460265006898 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 460265006899 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 460265006900 catalytic residue [active] 460265006901 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 460265006902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265006903 D-galactonate transporter; Region: 2A0114; TIGR00893 460265006904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265006905 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 460265006906 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265006907 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265006908 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 460265006909 Fusaric acid resistance protein family; Region: FUSC; pfam04632 460265006910 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 460265006911 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 460265006912 MarR family; Region: MarR; pfam01047 460265006913 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 460265006914 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 460265006915 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 460265006916 putative acyl-acceptor binding pocket; other site 460265006917 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 460265006918 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 460265006919 NAD(P) binding site [chemical binding]; other site 460265006920 Bacterial SH3 domain; Region: SH3_3; cl17532 460265006921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265006922 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 460265006923 NAD(P) binding site [chemical binding]; other site 460265006924 active site 460265006925 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 460265006926 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 460265006927 dimer interface [polypeptide binding]; other site 460265006928 active site 460265006929 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 460265006930 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 460265006931 active site 460265006932 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 460265006933 active site 2 [active] 460265006934 active site 1 [active] 460265006935 acyl carrier protein; Provisional; Region: PRK06508 460265006936 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 460265006937 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 460265006938 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 460265006939 active site 460265006940 HIGH motif; other site 460265006941 dimer interface [polypeptide binding]; other site 460265006942 KMSKS motif; other site 460265006943 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 460265006944 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 460265006945 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 460265006946 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 460265006947 Tetramer interface [polypeptide binding]; other site 460265006948 active site 460265006949 FMN-binding site [chemical binding]; other site 460265006950 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 460265006951 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 460265006952 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 460265006953 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 460265006954 dimerization interface [polypeptide binding]; other site 460265006955 active site 460265006956 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 460265006957 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 460265006958 putative active site [active] 460265006959 Zn binding site [ion binding]; other site 460265006960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 460265006961 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 460265006962 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 460265006963 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 460265006964 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 460265006965 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 460265006966 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 460265006967 carboxyltransferase (CT) interaction site; other site 460265006968 biotinylation site [posttranslational modification]; other site 460265006969 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 460265006970 putative active site pocket [active] 460265006971 dimerization interface [polypeptide binding]; other site 460265006972 putative catalytic residue [active] 460265006973 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 460265006974 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 460265006975 DNA-binding site [nucleotide binding]; DNA binding site 460265006976 RNA-binding motif; other site 460265006977 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 460265006978 DNA-binding site [nucleotide binding]; DNA binding site 460265006979 RNA-binding motif; other site 460265006980 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 460265006981 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 460265006982 elongation factor P; Validated; Region: PRK00529 460265006983 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 460265006984 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 460265006985 RNA binding site [nucleotide binding]; other site 460265006986 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 460265006987 RNA binding site [nucleotide binding]; other site 460265006988 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 460265006989 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 460265006990 motif 1; other site 460265006991 dimer interface [polypeptide binding]; other site 460265006992 active site 460265006993 motif 2; other site 460265006994 motif 3; other site 460265006995 lysine-2,3-aminomutase-related protein; Region: AblA_like_2; TIGR03822 460265006996 Radical SAM superfamily; Region: Radical_SAM; pfam04055 460265006997 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 460265006998 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 460265006999 putative C-terminal domain interface [polypeptide binding]; other site 460265007000 putative GSH binding site (G-site) [chemical binding]; other site 460265007001 putative dimer interface [polypeptide binding]; other site 460265007002 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 460265007003 N-terminal domain interface [polypeptide binding]; other site 460265007004 dimer interface [polypeptide binding]; other site 460265007005 substrate binding pocket (H-site) [chemical binding]; other site 460265007006 hypothetical protein; Validated; Region: PRK08245 460265007007 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 460265007008 Protein of unknown function, DUF599; Region: DUF599; pfam04654 460265007009 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 460265007010 elongation factor Tu; Reviewed; Region: PRK00049 460265007011 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 460265007012 G1 box; other site 460265007013 GEF interaction site [polypeptide binding]; other site 460265007014 GTP/Mg2+ binding site [chemical binding]; other site 460265007015 Switch I region; other site 460265007016 G2 box; other site 460265007017 G3 box; other site 460265007018 Switch II region; other site 460265007019 G4 box; other site 460265007020 G5 box; other site 460265007021 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 460265007022 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 460265007023 Antibiotic Binding Site [chemical binding]; other site 460265007024 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 460265007025 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 460265007026 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 460265007027 putative homodimer interface [polypeptide binding]; other site 460265007028 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 460265007029 heterodimer interface [polypeptide binding]; other site 460265007030 homodimer interface [polypeptide binding]; other site 460265007031 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 460265007032 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 460265007033 23S rRNA interface [nucleotide binding]; other site 460265007034 L7/L12 interface [polypeptide binding]; other site 460265007035 putative thiostrepton binding site; other site 460265007036 L25 interface [polypeptide binding]; other site 460265007037 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 460265007038 mRNA/rRNA interface [nucleotide binding]; other site 460265007039 B12 binding domain; Region: B12-binding; pfam02310 460265007040 B12 binding site [chemical binding]; other site 460265007041 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 460265007042 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 460265007043 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 460265007044 23S rRNA interface [nucleotide binding]; other site 460265007045 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 460265007046 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 460265007047 L11 interface [polypeptide binding]; other site 460265007048 putative EF-Tu interaction site [polypeptide binding]; other site 460265007049 putative EF-G interaction site [polypeptide binding]; other site 460265007050 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 460265007051 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 460265007052 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 460265007053 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 460265007054 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 460265007055 RPB11 interaction site [polypeptide binding]; other site 460265007056 RPB12 interaction site [polypeptide binding]; other site 460265007057 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 460265007058 RPB3 interaction site [polypeptide binding]; other site 460265007059 RPB1 interaction site [polypeptide binding]; other site 460265007060 RPB11 interaction site [polypeptide binding]; other site 460265007061 RPB10 interaction site [polypeptide binding]; other site 460265007062 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 460265007063 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 460265007064 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 460265007065 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 460265007066 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 460265007067 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 460265007068 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 460265007069 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 460265007070 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 460265007071 DNA binding site [nucleotide binding] 460265007072 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 460265007073 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 460265007074 S17 interaction site [polypeptide binding]; other site 460265007075 S8 interaction site; other site 460265007076 16S rRNA interaction site [nucleotide binding]; other site 460265007077 streptomycin interaction site [chemical binding]; other site 460265007078 23S rRNA interaction site [nucleotide binding]; other site 460265007079 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 460265007080 30S ribosomal protein S7; Validated; Region: PRK05302 460265007081 elongation factor G; Reviewed; Region: PRK00007 460265007082 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 460265007083 G1 box; other site 460265007084 putative GEF interaction site [polypeptide binding]; other site 460265007085 GTP/Mg2+ binding site [chemical binding]; other site 460265007086 Switch I region; other site 460265007087 G2 box; other site 460265007088 G3 box; other site 460265007089 Switch II region; other site 460265007090 G4 box; other site 460265007091 G5 box; other site 460265007092 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 460265007093 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 460265007094 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 460265007095 elongation factor Tu; Reviewed; Region: PRK00049 460265007096 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 460265007097 G1 box; other site 460265007098 GEF interaction site [polypeptide binding]; other site 460265007099 GTP/Mg2+ binding site [chemical binding]; other site 460265007100 Switch I region; other site 460265007101 G2 box; other site 460265007102 G3 box; other site 460265007103 Switch II region; other site 460265007104 G4 box; other site 460265007105 G5 box; other site 460265007106 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 460265007107 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 460265007108 Antibiotic Binding Site [chemical binding]; other site 460265007109 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 460265007110 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 460265007111 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 460265007112 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 460265007113 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 460265007114 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 460265007115 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 460265007116 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 460265007117 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 460265007118 putative translocon binding site; other site 460265007119 protein-rRNA interface [nucleotide binding]; other site 460265007120 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 460265007121 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 460265007122 G-X-X-G motif; other site 460265007123 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 460265007124 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 460265007125 23S rRNA interface [nucleotide binding]; other site 460265007126 5S rRNA interface [nucleotide binding]; other site 460265007127 putative antibiotic binding site [chemical binding]; other site 460265007128 L25 interface [polypeptide binding]; other site 460265007129 L27 interface [polypeptide binding]; other site 460265007130 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 460265007131 23S rRNA interface [nucleotide binding]; other site 460265007132 putative translocon interaction site; other site 460265007133 signal recognition particle (SRP54) interaction site; other site 460265007134 L23 interface [polypeptide binding]; other site 460265007135 trigger factor interaction site; other site 460265007136 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 460265007137 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 460265007138 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 460265007139 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 460265007140 RNA binding site [nucleotide binding]; other site 460265007141 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 460265007142 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 460265007143 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 460265007144 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 460265007145 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 460265007146 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 460265007147 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 460265007148 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 460265007149 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 460265007150 5S rRNA interface [nucleotide binding]; other site 460265007151 23S rRNA interface [nucleotide binding]; other site 460265007152 L5 interface [polypeptide binding]; other site 460265007153 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 460265007154 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 460265007155 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 460265007156 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 460265007157 23S rRNA binding site [nucleotide binding]; other site 460265007158 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 460265007159 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 460265007160 SecY translocase; Region: SecY; pfam00344 460265007161 adenylate kinase; Reviewed; Region: adk; PRK00279 460265007162 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 460265007163 AMP-binding site [chemical binding]; other site 460265007164 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 460265007165 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 460265007166 30S ribosomal protein S13; Region: bact_S13; TIGR03631 460265007167 30S ribosomal protein S11; Validated; Region: PRK05309 460265007168 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 460265007169 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 460265007170 alphaNTD - beta interaction site [polypeptide binding]; other site 460265007171 alphaNTD homodimer interface [polypeptide binding]; other site 460265007172 alphaNTD - beta' interaction site [polypeptide binding]; other site 460265007173 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 460265007174 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 460265007175 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 460265007176 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 460265007177 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 460265007178 catalytic residue [active] 460265007179 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 460265007180 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 460265007181 dimerization interface [polypeptide binding]; other site 460265007182 ligand binding site [chemical binding]; other site 460265007183 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 460265007184 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 460265007185 SdiA-regulated; Region: SdiA-regulated; cd09971 460265007186 putative active site [active] 460265007187 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 460265007188 dimerization interface [polypeptide binding]; other site 460265007189 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 460265007190 NAD binding site [chemical binding]; other site 460265007191 ligand binding site [chemical binding]; other site 460265007192 catalytic site [active] 460265007193 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 460265007194 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 460265007195 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 460265007196 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 460265007197 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 460265007198 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 460265007199 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 460265007200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265007201 NAD(P) binding site [chemical binding]; other site 460265007202 active site 460265007203 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 460265007204 active site 460265007205 cosubstrate binding site; other site 460265007206 substrate binding site [chemical binding]; other site 460265007207 catalytic site [active] 460265007208 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 460265007209 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 460265007210 substrate-cofactor binding pocket; other site 460265007211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265007212 catalytic residue [active] 460265007213 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 460265007214 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 460265007215 active site 460265007216 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 460265007217 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 460265007218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265007219 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 460265007220 Enoylreductase; Region: PKS_ER; smart00829 460265007221 NAD(P) binding site [chemical binding]; other site 460265007222 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 460265007223 KR domain; Region: KR; pfam08659 460265007224 putative NADP binding site [chemical binding]; other site 460265007225 active site 460265007226 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 460265007227 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 460265007228 AsnC family; Region: AsnC_trans_reg; pfam01037 460265007229 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 460265007230 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 460265007231 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 460265007232 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 460265007233 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 460265007234 Probable Catalytic site; other site 460265007235 metal-binding site 460265007236 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 460265007237 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 460265007238 Probable Catalytic site; other site 460265007239 metal-binding site 460265007240 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 460265007241 DNA binding residues [nucleotide binding] 460265007242 Dienelactone hydrolase family; Region: DLH; pfam01738 460265007243 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 460265007244 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 460265007245 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 460265007246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 460265007247 Histidine kinase; Region: HisKA_2; pfam07568 460265007248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265007249 ATP binding site [chemical binding]; other site 460265007250 Mg2+ binding site [ion binding]; other site 460265007251 G-X-G motif; other site 460265007252 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 460265007253 putative ADP-binding pocket [chemical binding]; other site 460265007254 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265007255 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 460265007256 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265007257 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265007258 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 460265007259 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 460265007260 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 460265007261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265007262 Walker A/P-loop; other site 460265007263 ATP binding site [chemical binding]; other site 460265007264 Q-loop/lid; other site 460265007265 ABC transporter signature motif; other site 460265007266 Walker B; other site 460265007267 D-loop; other site 460265007268 H-loop/switch region; other site 460265007269 aspartate aminotransferase; Provisional; Region: PRK05764 460265007270 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 460265007271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265007272 homodimer interface [polypeptide binding]; other site 460265007273 catalytic residue [active] 460265007274 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 460265007275 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 460265007276 active site 460265007277 catalytic residues [active] 460265007278 DNA binding site [nucleotide binding] 460265007279 Int/Topo IB signature motif; other site 460265007280 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 460265007281 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 460265007282 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 460265007283 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 460265007284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265007285 non-specific DNA binding site [nucleotide binding]; other site 460265007286 salt bridge; other site 460265007287 sequence-specific DNA binding site [nucleotide binding]; other site 460265007288 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 460265007289 Catalytic site [active] 460265007290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265007291 sequence-specific DNA binding site [nucleotide binding]; other site 460265007292 salt bridge; other site 460265007293 VRR-NUC domain; Region: VRR_NUC; pfam08774 460265007294 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 460265007295 polymerase nucleotide-binding site; other site 460265007296 DNA-binding residues [nucleotide binding]; DNA binding site 460265007297 nucleotide binding site [chemical binding]; other site 460265007298 primase nucleotide-binding site [nucleotide binding]; other site 460265007299 Virulence-associated protein E; Region: VirE; pfam05272 460265007300 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265007301 Transcription termination factor nusG; Region: NusG; pfam02357 460265007302 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 460265007303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265007304 putative substrate translocation pore; other site 460265007305 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265007306 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265007307 flexible hinge region; other site 460265007308 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 460265007309 non-specific DNA interactions [nucleotide binding]; other site 460265007310 DNA binding site [nucleotide binding] 460265007311 sequence specific DNA binding site [nucleotide binding]; other site 460265007312 putative cAMP binding site [chemical binding]; other site 460265007313 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 460265007314 Phage terminase, small subunit; Region: Terminase_4; cl01525 460265007315 Phage Terminase; Region: Terminase_1; pfam03354 460265007316 Phage portal protein; Region: Phage_portal; pfam04860 460265007317 Phage-related protein [Function unknown]; Region: COG4695 460265007318 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 460265007319 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 460265007320 tandem repeat interface [polypeptide binding]; other site 460265007321 oligomer interface [polypeptide binding]; other site 460265007322 active site residues [active] 460265007323 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 460265007324 Phage capsid family; Region: Phage_capsid; pfam05065 460265007325 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 460265007326 oligomerization interface [polypeptide binding]; other site 460265007327 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 460265007328 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 460265007329 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 460265007330 Phage major tail protein 2; Region: Phage_tail_2; cl11463 460265007331 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 460265007332 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 460265007333 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 460265007334 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 460265007335 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 460265007336 NlpC/P60 family; Region: NLPC_P60; cl17555 460265007337 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 460265007338 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 460265007339 Putative phage tail protein; Region: Phage-tail_3; pfam13550 460265007340 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 460265007341 Catalytic domain of bacteriophage endosialidase; Region: End_tail_spike; pfam12219 460265007342 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 460265007343 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 460265007344 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 460265007345 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 460265007346 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265007347 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265007348 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 460265007349 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 460265007350 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 460265007351 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265007352 catalytic loop [active] 460265007353 iron binding site [ion binding]; other site 460265007354 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 460265007355 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 460265007356 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 460265007357 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265007358 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265007359 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265007360 putative ligand binding site [chemical binding]; other site 460265007361 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265007362 TM-ABC transporter signature motif; other site 460265007363 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265007364 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265007365 TM-ABC transporter signature motif; other site 460265007366 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265007367 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265007368 Walker A/P-loop; other site 460265007369 ATP binding site [chemical binding]; other site 460265007370 Q-loop/lid; other site 460265007371 ABC transporter signature motif; other site 460265007372 Walker B; other site 460265007373 D-loop; other site 460265007374 H-loop/switch region; other site 460265007375 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265007376 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265007377 Walker A/P-loop; other site 460265007378 ATP binding site [chemical binding]; other site 460265007379 Q-loop/lid; other site 460265007380 ABC transporter signature motif; other site 460265007381 Walker B; other site 460265007382 D-loop; other site 460265007383 H-loop/switch region; other site 460265007384 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 460265007385 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265007386 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265007387 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265007388 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 460265007389 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265007390 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 460265007391 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 460265007392 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 460265007393 TadE-like protein; Region: TadE; pfam07811 460265007394 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 460265007395 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 460265007396 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 460265007397 N-terminal plug; other site 460265007398 ligand-binding site [chemical binding]; other site 460265007399 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 460265007400 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 460265007401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265007402 S-adenosylmethionine binding site [chemical binding]; other site 460265007403 Erythromycin esterase; Region: Erythro_esteras; pfam05139 460265007404 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265007405 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265007406 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265007407 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265007408 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 460265007409 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 460265007410 active site 460265007411 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 460265007412 Hint domain; Region: Hint_2; pfam13403 460265007413 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 460265007414 heme-binding site [chemical binding]; other site 460265007415 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 460265007416 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 460265007417 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 460265007418 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 460265007419 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 460265007420 Aspartase; Region: Aspartase; cd01357 460265007421 active sites [active] 460265007422 tetramer interface [polypeptide binding]; other site 460265007423 cell density-dependent motility repressor; Provisional; Region: PRK10082 460265007424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265007425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 460265007426 dimerization interface [polypeptide binding]; other site 460265007427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265007428 TPR motif; other site 460265007429 TPR repeat; Region: TPR_11; pfam13414 460265007430 binding surface 460265007431 TPR repeat; Region: TPR_11; pfam13414 460265007432 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265007433 binding surface 460265007434 TPR motif; other site 460265007435 TPR repeat; Region: TPR_11; pfam13414 460265007436 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 460265007437 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 460265007438 NAD binding site [chemical binding]; other site 460265007439 ATP-grasp domain; Region: ATP-grasp; pfam02222 460265007440 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 460265007441 Uncharacterized small protein [Function unknown]; Region: COG5570 460265007442 acyl-CoA synthetase; Validated; Region: PRK08162 460265007443 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 460265007444 acyl-activating enzyme (AAE) consensus motif; other site 460265007445 putative active site [active] 460265007446 AMP binding site [chemical binding]; other site 460265007447 putative CoA binding site [chemical binding]; other site 460265007448 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 460265007449 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 460265007450 acyl-activating enzyme (AAE) consensus motif; other site 460265007451 putative AMP binding site [chemical binding]; other site 460265007452 putative active site [active] 460265007453 putative CoA binding site [chemical binding]; other site 460265007454 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 460265007455 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 460265007456 active site 460265007457 FMN binding site [chemical binding]; other site 460265007458 substrate binding site [chemical binding]; other site 460265007459 homotetramer interface [polypeptide binding]; other site 460265007460 catalytic residue [active] 460265007461 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 460265007462 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 460265007463 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 460265007464 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 460265007465 tetramer interface [polypeptide binding]; other site 460265007466 active site 460265007467 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 460265007468 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 460265007469 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 460265007470 heterodimer interface [polypeptide binding]; other site 460265007471 active site 460265007472 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 460265007473 heterodimer interface [polypeptide binding]; other site 460265007474 multimer interface [polypeptide binding]; other site 460265007475 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 460265007476 active site 460265007477 Transcriptional regulator [Transcription]; Region: IclR; COG1414 460265007478 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 460265007479 Bacterial transcriptional regulator; Region: IclR; pfam01614 460265007480 phosphoglucomutase; Region: PLN02307 460265007481 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 460265007482 active site 460265007483 substrate binding site [chemical binding]; other site 460265007484 metal binding site [ion binding]; metal-binding site 460265007485 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 460265007486 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 460265007487 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 460265007488 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265007489 Pirin-related protein [General function prediction only]; Region: COG1741 460265007490 Pirin; Region: Pirin; pfam02678 460265007491 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 460265007492 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 460265007493 Transcriptional regulators [Transcription]; Region: MarR; COG1846 460265007494 MarR family; Region: MarR_2; pfam12802 460265007495 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 460265007496 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 460265007497 Cl- selectivity filter; other site 460265007498 Cl- binding residues [ion binding]; other site 460265007499 pore gating glutamate residue; other site 460265007500 dimer interface [polypeptide binding]; other site 460265007501 FOG: CBS domain [General function prediction only]; Region: COG0517 460265007502 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 460265007503 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265007504 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 460265007505 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265007506 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265007507 catalytic residue [active] 460265007508 pyruvate kinase; Provisional; Region: PRK06247 460265007509 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 460265007510 domain interfaces; other site 460265007511 active site 460265007512 NnrS protein; Region: NnrS; pfam05940 460265007513 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 460265007514 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 460265007515 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 460265007516 substrate-cofactor binding pocket; other site 460265007517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265007518 catalytic residue [active] 460265007519 NnrU protein; Region: NnrU; cl17713 460265007520 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 460265007521 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265007522 FeS/SAM binding site; other site 460265007523 HemN C-terminal domain; Region: HemN_C; pfam06969 460265007524 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 460265007525 Low-spin heme binding site [chemical binding]; other site 460265007526 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 460265007527 Putative water exit pathway; other site 460265007528 Binuclear center (active site) [active] 460265007529 Putative proton exit pathway; other site 460265007530 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 460265007531 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 460265007532 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 460265007533 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 460265007534 Cytochrome c; Region: Cytochrom_C; pfam00034 460265007535 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 460265007536 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 460265007537 FOG: CBS domain [General function prediction only]; Region: COG0517 460265007538 PAS fold; Region: PAS_4; pfam08448 460265007539 PAS domain S-box; Region: sensory_box; TIGR00229 460265007540 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265007541 putative active site [active] 460265007542 heme pocket [chemical binding]; other site 460265007543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265007544 dimer interface [polypeptide binding]; other site 460265007545 phosphorylation site [posttranslational modification] 460265007546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265007547 ATP binding site [chemical binding]; other site 460265007548 Mg2+ binding site [ion binding]; other site 460265007549 G-X-G motif; other site 460265007550 response regulator FixJ; Provisional; Region: fixJ; PRK09390 460265007551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265007552 active site 460265007553 phosphorylation site [posttranslational modification] 460265007554 intermolecular recognition site; other site 460265007555 dimerization interface [polypeptide binding]; other site 460265007556 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265007557 DNA binding residues [nucleotide binding] 460265007558 dimerization interface [polypeptide binding]; other site 460265007559 Response regulator receiver domain; Region: Response_reg; pfam00072 460265007560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265007561 active site 460265007562 phosphorylation site [posttranslational modification] 460265007563 intermolecular recognition site; other site 460265007564 dimerization interface [polypeptide binding]; other site 460265007565 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 460265007566 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 460265007567 dimer interface [polypeptide binding]; other site 460265007568 putative functional site; other site 460265007569 putative MPT binding site; other site 460265007570 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 460265007571 MPT binding site; other site 460265007572 trimer interface [polypeptide binding]; other site 460265007573 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 460265007574 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265007575 FeS/SAM binding site; other site 460265007576 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 460265007577 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 460265007578 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 460265007579 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 460265007580 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 460265007581 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 460265007582 4Fe-4S binding domain; Region: Fer4; cl02805 460265007583 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 460265007584 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 460265007585 [4Fe-4S] binding site [ion binding]; other site 460265007586 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 460265007587 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 460265007588 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 460265007589 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 460265007590 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 460265007591 molybdopterin cofactor binding site; other site 460265007592 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265007593 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265007594 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265007595 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265007596 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 460265007597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265007598 putative substrate translocation pore; other site 460265007599 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 460265007600 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265007601 ligand binding site [chemical binding]; other site 460265007602 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 460265007603 putative switch regulator; other site 460265007604 non-specific DNA interactions [nucleotide binding]; other site 460265007605 DNA binding site [nucleotide binding] 460265007606 sequence specific DNA binding site [nucleotide binding]; other site 460265007607 putative cAMP binding site [chemical binding]; other site 460265007608 PAS domain; Region: PAS_9; pfam13426 460265007609 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265007610 putative active site [active] 460265007611 heme pocket [chemical binding]; other site 460265007612 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 460265007613 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 460265007614 heme-binding site [chemical binding]; other site 460265007615 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 460265007616 FAD binding pocket [chemical binding]; other site 460265007617 FAD binding motif [chemical binding]; other site 460265007618 phosphate binding motif [ion binding]; other site 460265007619 beta-alpha-beta structure motif; other site 460265007620 NAD binding pocket [chemical binding]; other site 460265007621 Heme binding pocket [chemical binding]; other site 460265007622 Predicted transcriptional regulator [Transcription]; Region: COG1959 460265007623 Transcriptional regulator; Region: Rrf2; cl17282 460265007624 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 460265007625 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 460265007626 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265007627 cobyric acid synthase; Provisional; Region: PRK00784 460265007628 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 460265007629 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 460265007630 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 460265007631 catalytic triad [active] 460265007632 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 460265007633 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 460265007634 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 460265007635 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 460265007636 homodimer interface [polypeptide binding]; other site 460265007637 Walker A motif; other site 460265007638 ATP binding site [chemical binding]; other site 460265007639 hydroxycobalamin binding site [chemical binding]; other site 460265007640 Walker B motif; other site 460265007641 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 460265007642 homotrimer interface [polypeptide binding]; other site 460265007643 Walker A motif; other site 460265007644 GTP binding site [chemical binding]; other site 460265007645 Walker B motif; other site 460265007646 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 460265007647 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 460265007648 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 460265007649 dimer interface [polypeptide binding]; other site 460265007650 [2Fe-2S] cluster binding site [ion binding]; other site 460265007651 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 460265007652 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 460265007653 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 460265007654 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321 460265007655 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 460265007656 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 460265007657 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 460265007658 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 460265007659 Precorrin-8X methylmutase; Region: CbiC; pfam02570 460265007660 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 460265007661 active site 460265007662 SAM binding site [chemical binding]; other site 460265007663 homodimer interface [polypeptide binding]; other site 460265007664 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 460265007665 active site 460265007666 SAM binding site [chemical binding]; other site 460265007667 homodimer interface [polypeptide binding]; other site 460265007668 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 460265007669 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 460265007670 active site 460265007671 putative homodimer interface [polypeptide binding]; other site 460265007672 SAM binding site [chemical binding]; other site 460265007673 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 460265007674 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 460265007675 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 460265007676 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 460265007677 active site 460265007678 SAM binding site [chemical binding]; other site 460265007679 homodimer interface [polypeptide binding]; other site 460265007680 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 460265007681 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 460265007682 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 460265007683 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 460265007684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265007685 non-specific DNA binding site [nucleotide binding]; other site 460265007686 salt bridge; other site 460265007687 sequence-specific DNA binding site [nucleotide binding]; other site 460265007688 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 460265007689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265007690 putative substrate translocation pore; other site 460265007691 Major Facilitator Superfamily; Region: MFS_1; pfam07690 460265007692 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 460265007693 Bacterial sugar transferase; Region: Bac_transf; pfam02397 460265007694 SnoaL-like domain; Region: SnoaL_2; pfam12680 460265007695 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 460265007696 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 460265007697 dimer interface [polypeptide binding]; other site 460265007698 anticodon binding site; other site 460265007699 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 460265007700 motif 1; other site 460265007701 dimer interface [polypeptide binding]; other site 460265007702 active site 460265007703 motif 2; other site 460265007704 GAD domain; Region: GAD; pfam02938 460265007705 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 460265007706 active site 460265007707 motif 3; other site 460265007708 putative acetyltransferase; Provisional; Region: PRK03624 460265007709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 460265007710 Coenzyme A binding pocket [chemical binding]; other site 460265007711 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 460265007712 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 460265007713 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 460265007714 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 460265007715 Malic enzyme, N-terminal domain; Region: malic; pfam00390 460265007716 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 460265007717 NAD(P) binding pocket [chemical binding]; other site 460265007718 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 460265007719 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 460265007720 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 460265007721 tetrameric interface [polypeptide binding]; other site 460265007722 NAD binding site [chemical binding]; other site 460265007723 catalytic residues [active] 460265007724 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 460265007725 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 460265007726 substrate binding pocket [chemical binding]; other site 460265007727 FAD binding site [chemical binding]; other site 460265007728 catalytic base [active] 460265007729 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 460265007730 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 460265007731 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 460265007732 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 460265007733 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 460265007734 active site 460265007735 HIGH motif; other site 460265007736 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 460265007737 KMSK motif region; other site 460265007738 tRNA binding surface [nucleotide binding]; other site 460265007739 DALR anticodon binding domain; Region: DALR_1; smart00836 460265007740 anticodon binding site; other site 460265007741 Sporulation related domain; Region: SPOR; pfam05036 460265007742 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 460265007743 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 460265007744 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 460265007745 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 460265007746 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 460265007747 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 460265007748 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 460265007749 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 460265007750 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 460265007751 Protein of unknown function (DUF815); Region: DUF815; pfam05673 460265007752 Walker A motif; other site 460265007753 ATP binding site [chemical binding]; other site 460265007754 Walker B motif; other site 460265007755 Preprotein translocase subunit; Region: YajC; pfam02699 460265007756 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 460265007757 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 460265007758 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 460265007759 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 460265007760 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 460265007761 Protein export membrane protein; Region: SecD_SecF; pfam02355 460265007762 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 460265007763 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 460265007764 substrate binding pocket [chemical binding]; other site 460265007765 substrate-Mg2+ binding site; other site 460265007766 aspartate-rich region 2; other site 460265007767 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 460265007768 Glucose inhibited division protein A; Region: GIDA; pfam01134 460265007769 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 460265007770 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 460265007771 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 460265007772 protein binding site [polypeptide binding]; other site 460265007773 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 460265007774 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 460265007775 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 460265007776 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 460265007777 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 460265007778 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 460265007779 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 460265007780 tandem repeat interface [polypeptide binding]; other site 460265007781 oligomer interface [polypeptide binding]; other site 460265007782 active site residues [active] 460265007783 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 460265007784 IHF dimer interface [polypeptide binding]; other site 460265007785 IHF - DNA interface [nucleotide binding]; other site 460265007786 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 460265007787 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 460265007788 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 460265007789 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 460265007790 putative dimer interface [polypeptide binding]; other site 460265007791 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 460265007792 active site 460265007793 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 460265007794 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 460265007795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265007796 catalytic residue [active] 460265007797 potential protein location (hypothetical protein Mnod_2205 [Methylobacterium nodulans ORS 2060]) that overlaps RNA (tRNA-M) 460265007798 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 460265007799 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 460265007800 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 460265007801 putative dimer interface [polypeptide binding]; other site 460265007802 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 460265007803 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 460265007804 putative dimer interface [polypeptide binding]; other site 460265007805 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 460265007806 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 460265007807 dimerization interface [polypeptide binding]; other site 460265007808 metal binding site [ion binding]; metal-binding site 460265007809 Predicted transcriptional regulators [Transcription]; Region: COG1733 460265007810 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 460265007811 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 460265007812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265007813 NAD(P) binding site [chemical binding]; other site 460265007814 active site 460265007815 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 460265007816 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 460265007817 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 460265007818 Protein of unknown function, DUF606; Region: DUF606; pfam04657 460265007819 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 460265007820 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 460265007821 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 460265007822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265007823 Walker A/P-loop; other site 460265007824 ATP binding site [chemical binding]; other site 460265007825 Q-loop/lid; other site 460265007826 ABC transporter signature motif; other site 460265007827 Walker B; other site 460265007828 D-loop; other site 460265007829 H-loop/switch region; other site 460265007830 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265007831 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265007832 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265007833 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 460265007834 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 460265007835 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 460265007836 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 460265007837 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 460265007838 Chromate transporter; Region: Chromate_transp; pfam02417 460265007839 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 460265007840 active site residue [active] 460265007841 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 460265007842 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 460265007843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265007844 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 460265007845 Walker A/P-loop; other site 460265007846 ATP binding site [chemical binding]; other site 460265007847 Q-loop/lid; other site 460265007848 ABC transporter signature motif; other site 460265007849 Walker B; other site 460265007850 D-loop; other site 460265007851 H-loop/switch region; other site 460265007852 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 460265007853 putative homodimer interface [polypeptide binding]; other site 460265007854 putative homotetramer interface [polypeptide binding]; other site 460265007855 putative metal binding site [ion binding]; other site 460265007856 putative homodimer-homodimer interface [polypeptide binding]; other site 460265007857 putative allosteric switch controlling residues; other site 460265007858 H+ Antiporter protein; Region: 2A0121; TIGR00900 460265007859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265007860 putative substrate translocation pore; other site 460265007861 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 460265007862 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 460265007863 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 460265007864 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 460265007865 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 460265007866 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265007867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265007868 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 460265007869 putative dimerization interface [polypeptide binding]; other site 460265007870 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 460265007871 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 460265007872 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 460265007873 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 460265007874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265007875 NAD(P) binding site [chemical binding]; other site 460265007876 active site 460265007877 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 460265007878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 460265007879 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 460265007880 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 460265007881 Walker A/P-loop; other site 460265007882 ATP binding site [chemical binding]; other site 460265007883 Q-loop/lid; other site 460265007884 ABC transporter signature motif; other site 460265007885 Walker B; other site 460265007886 D-loop; other site 460265007887 H-loop/switch region; other site 460265007888 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 460265007889 NMT1-like family; Region: NMT1_2; pfam13379 460265007890 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 460265007891 tartrate dehydrogenase; Region: TTC; TIGR02089 460265007892 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 460265007893 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 460265007894 substrate binding site [chemical binding]; other site 460265007895 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 460265007896 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 460265007897 substrate binding site [chemical binding]; other site 460265007898 ligand binding site [chemical binding]; other site 460265007899 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-1; cd12808 460265007900 catalytic site [active] 460265007901 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 460265007902 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 460265007903 active site 460265007904 catalytic tetrad [active] 460265007905 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-2; cd12809 460265007906 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 460265007907 catalytic site [active] 460265007908 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 460265007909 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265007910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265007911 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265007912 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 460265007913 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 460265007914 Helix-turn-helix domain; Region: HTH_18; pfam12833 460265007915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265007916 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 460265007917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 460265007918 Coenzyme A binding pocket [chemical binding]; other site 460265007919 Ion channel; Region: Ion_trans_2; pfam07885 460265007920 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 460265007921 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 460265007922 Sulfate transporter family; Region: Sulfate_transp; pfam00916 460265007923 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 460265007924 Coenzyme A transferase; Region: CoA_trans; cl17247 460265007925 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 460265007926 Predicted integral membrane protein (DUF2270); Region: DUF2270; cl02337 460265007927 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 460265007928 Hint domain; Region: Hint_2; pfam13403 460265007929 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 460265007930 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 460265007931 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 460265007932 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 460265007933 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 460265007934 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 460265007935 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 460265007936 CoenzymeA binding site [chemical binding]; other site 460265007937 subunit interaction site [polypeptide binding]; other site 460265007938 PHB binding site; other site 460265007939 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 460265007940 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 460265007941 conserved cys residue [active] 460265007942 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265007943 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265007944 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 460265007945 Zn2+ binding site [ion binding]; other site 460265007946 Mg2+ binding site [ion binding]; other site 460265007947 Methyltransferase domain; Region: Methyltransf_12; pfam08242 460265007948 S-adenosylmethionine binding site [chemical binding]; other site 460265007949 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 460265007950 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 460265007951 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 460265007952 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 460265007953 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 460265007954 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 460265007955 oligomer interface [polypeptide binding]; other site 460265007956 classical (c) SDRs; Region: SDR_c; cd05233 460265007957 NAD(P) binding site [chemical binding]; other site 460265007958 active site 460265007959 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 460265007960 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 460265007961 G1 box; other site 460265007962 putative GEF interaction site [polypeptide binding]; other site 460265007963 GTP/Mg2+ binding site [chemical binding]; other site 460265007964 Switch I region; other site 460265007965 G2 box; other site 460265007966 G3 box; other site 460265007967 Switch II region; other site 460265007968 G4 box; other site 460265007969 G5 box; other site 460265007970 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 460265007971 Response regulator receiver domain; Region: Response_reg; pfam00072 460265007972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265007973 active site 460265007974 phosphorylation site [posttranslational modification] 460265007975 intermolecular recognition site; other site 460265007976 dimerization interface [polypeptide binding]; other site 460265007977 Sensors of blue-light using FAD; Region: BLUF; pfam04940 460265007978 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 460265007979 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 460265007980 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 460265007981 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 460265007982 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 460265007983 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 460265007984 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 460265007985 cyclase homology domain; Region: CHD; cd07302 460265007986 nucleotidyl binding site; other site 460265007987 metal binding site [ion binding]; metal-binding site 460265007988 dimer interface [polypeptide binding]; other site 460265007989 Predicted integral membrane protein [Function unknown]; Region: COG5616 460265007990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265007991 TPR motif; other site 460265007992 binding surface 460265007993 TPR repeat; Region: TPR_11; pfam13414 460265007994 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265007995 binding surface 460265007996 TPR motif; other site 460265007997 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 460265007998 putative Zn2+ binding site [ion binding]; other site 460265007999 putative DNA binding site [nucleotide binding]; other site 460265008000 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 460265008001 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 460265008002 Sulphur transport; Region: Sulf_transp; pfam04143 460265008003 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 460265008004 active site 460265008005 Erythromycin esterase; Region: Erythro_esteras; pfam05139 460265008006 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 460265008007 Phasin protein; Region: Phasin_2; cl11491 460265008008 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 460265008009 Malic enzyme, N-terminal domain; Region: malic; pfam00390 460265008010 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 460265008011 putative NAD(P) binding site [chemical binding]; other site 460265008012 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 460265008013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265008014 dimer interface [polypeptide binding]; other site 460265008015 phosphorylation site [posttranslational modification] 460265008016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265008017 ATP binding site [chemical binding]; other site 460265008018 Mg2+ binding site [ion binding]; other site 460265008019 G-X-G motif; other site 460265008020 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 460265008021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265008022 active site 460265008023 phosphorylation site [posttranslational modification] 460265008024 intermolecular recognition site; other site 460265008025 dimerization interface [polypeptide binding]; other site 460265008026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265008027 Walker A motif; other site 460265008028 ATP binding site [chemical binding]; other site 460265008029 Walker B motif; other site 460265008030 arginine finger; other site 460265008031 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 460265008032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265008033 Major Facilitator Superfamily; Region: MFS_1; pfam07690 460265008034 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 460265008035 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 460265008036 transmembrane helices; other site 460265008037 Domain of unknown function DUF77; Region: DUF77; pfam01910 460265008038 Phasin protein; Region: Phasin_2; cl11491 460265008039 FOG: CBS domain [General function prediction only]; Region: COG0517 460265008040 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 460265008041 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 460265008042 active site 460265008043 DNA binding site [nucleotide binding] 460265008044 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 460265008045 oxyanion hole [active] 460265008046 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 460265008047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265008048 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265008049 dimerization interface [polypeptide binding]; other site 460265008050 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 460265008051 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 460265008052 Trp docking motif [polypeptide binding]; other site 460265008053 dimer interface [polypeptide binding]; other site 460265008054 active site 460265008055 small subunit binding site [polypeptide binding]; other site 460265008056 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 460265008057 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265008058 substrate binding pocket [chemical binding]; other site 460265008059 membrane-bound complex binding site; other site 460265008060 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 460265008061 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 460265008062 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 460265008063 Cytochrome c; Region: Cytochrom_C; pfam00034 460265008064 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 460265008065 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 460265008066 D-pathway; other site 460265008067 Putative ubiquinol binding site [chemical binding]; other site 460265008068 Low-spin heme (heme b) binding site [chemical binding]; other site 460265008069 Putative water exit pathway; other site 460265008070 Binuclear center (heme o3/CuB) [ion binding]; other site 460265008071 K-pathway; other site 460265008072 Putative proton exit pathway; other site 460265008073 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 460265008074 Subunit I/III interface [polypeptide binding]; other site 460265008075 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 460265008076 Cytochrome c; Region: Cytochrom_C; cl11414 460265008077 DNA topoisomerase III; Validated; Region: PRK08173 460265008078 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 460265008079 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 460265008080 putative dimer interface [polypeptide binding]; other site 460265008081 Predicted integral membrane protein [Function unknown]; Region: COG5473 460265008082 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 460265008083 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 460265008084 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 460265008085 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 460265008086 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 460265008087 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 460265008088 Subunit I/III interface [polypeptide binding]; other site 460265008089 Predicted small integral membrane protein [Function unknown]; Region: COG5605 460265008090 Dodecin; Region: Dodecin; pfam07311 460265008091 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265008092 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 460265008093 putative trimer interface [polypeptide binding]; other site 460265008094 putative CoA binding site [chemical binding]; other site 460265008095 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 460265008096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265008097 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265008098 dimerization interface [polypeptide binding]; other site 460265008099 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 460265008100 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 460265008101 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 460265008102 putative alpha subunit interface [polypeptide binding]; other site 460265008103 putative active site [active] 460265008104 putative substrate binding site [chemical binding]; other site 460265008105 Fe binding site [ion binding]; other site 460265008106 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 460265008107 inter-subunit interface; other site 460265008108 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 460265008109 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265008110 catalytic loop [active] 460265008111 iron binding site [ion binding]; other site 460265008112 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 460265008113 FAD binding pocket [chemical binding]; other site 460265008114 FAD binding motif [chemical binding]; other site 460265008115 phosphate binding motif [ion binding]; other site 460265008116 beta-alpha-beta structure motif; other site 460265008117 NAD binding pocket [chemical binding]; other site 460265008118 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 460265008119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265008120 NAD(P) binding site [chemical binding]; other site 460265008121 active site 460265008122 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 460265008123 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 460265008124 dimer interface [polypeptide binding]; other site 460265008125 active site 460265008126 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 460265008127 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 460265008128 metal binding site [ion binding]; metal-binding site 460265008129 substrate binding pocket [chemical binding]; other site 460265008130 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 460265008131 benzoate transport; Region: 2A0115; TIGR00895 460265008132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265008133 putative substrate translocation pore; other site 460265008134 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 460265008135 Recombinase; Region: Recombinase; pfam07508 460265008136 Predicted transcriptional regulators [Transcription]; Region: COG1733 460265008137 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 460265008138 Predicted flavoprotein [General function prediction only]; Region: COG0431 460265008139 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 460265008140 Cache domain; Region: Cache_1; pfam02743 460265008141 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 460265008142 dimerization interface [polypeptide binding]; other site 460265008143 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 460265008144 cyclase homology domain; Region: CHD; cd07302 460265008145 nucleotidyl binding site; other site 460265008146 metal binding site [ion binding]; metal-binding site 460265008147 dimer interface [polypeptide binding]; other site 460265008148 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 460265008149 zinc binding site [ion binding]; other site 460265008150 putative ligand binding site [chemical binding]; other site 460265008151 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 460265008152 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 460265008153 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 460265008154 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 460265008155 Walker A/P-loop; other site 460265008156 ATP binding site [chemical binding]; other site 460265008157 Q-loop/lid; other site 460265008158 ABC transporter signature motif; other site 460265008159 Walker B; other site 460265008160 D-loop; other site 460265008161 H-loop/switch region; other site 460265008162 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 460265008163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265008164 dimer interface [polypeptide binding]; other site 460265008165 conserved gate region; other site 460265008166 putative PBP binding loops; other site 460265008167 ABC-ATPase subunit interface; other site 460265008168 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 460265008169 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265008170 substrate binding pocket [chemical binding]; other site 460265008171 membrane-bound complex binding site; other site 460265008172 hinge residues; other site 460265008173 Domain of unknown function (DUF1476); Region: DUF1476; cl11571 460265008174 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 460265008175 MgtC family; Region: MgtC; pfam02308 460265008176 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 460265008177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 460265008178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265008179 S-adenosylmethionine binding site [chemical binding]; other site 460265008180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265008181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265008182 AAA domain; Region: AAA_28; pfam13521 460265008183 Predicted ATPase [General function prediction only]; Region: COG3911 460265008184 PilZ domain; Region: PilZ; pfam07238 460265008185 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265008186 dimerization interface [polypeptide binding]; other site 460265008187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 460265008188 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 460265008189 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 460265008190 dimer interface [polypeptide binding]; other site 460265008191 active site 460265008192 catalytic residue [active] 460265008193 metal binding site [ion binding]; metal-binding site 460265008194 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 460265008195 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 460265008196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265008197 putative substrate translocation pore; other site 460265008198 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265008199 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265008200 dimerization interface [polypeptide binding]; other site 460265008201 Divergent AAA domain; Region: AAA_4; pfam04326 460265008202 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 460265008203 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 460265008204 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 460265008205 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 460265008206 DNA-binding interface [nucleotide binding]; DNA binding site 460265008207 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265008208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265008209 TPR motif; other site 460265008210 TPR repeat; Region: TPR_11; pfam13414 460265008211 binding surface 460265008212 TPR repeat; Region: TPR_11; pfam13414 460265008213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265008214 binding surface 460265008215 TPR motif; other site 460265008216 TPR repeat; Region: TPR_11; pfam13414 460265008217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265008218 binding surface 460265008219 TPR motif; other site 460265008220 TPR repeat; Region: TPR_11; pfam13414 460265008221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265008222 binding surface 460265008223 TPR motif; other site 460265008224 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 460265008225 Tetratricopeptide repeat; Region: TPR_1; pfam00515 460265008226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265008227 binding surface 460265008228 TPR motif; other site 460265008229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265008230 binding surface 460265008231 TPR motif; other site 460265008232 TPR repeat; Region: TPR_11; pfam13414 460265008233 Caspase domain; Region: Peptidase_C14; pfam00656 460265008234 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 460265008235 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 460265008236 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 460265008237 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 460265008238 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 460265008239 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 460265008240 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 460265008241 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 460265008242 Phage protein GP46; Region: GP46; cl01814 460265008243 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 460265008244 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 460265008245 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 460265008246 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 460265008247 Phage tail tube protein; Region: Tail_tube; pfam10618 460265008248 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 460265008249 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 460265008250 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 460265008251 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 460265008252 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 460265008253 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 460265008254 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 460265008255 tandem repeat interface [polypeptide binding]; other site 460265008256 oligomer interface [polypeptide binding]; other site 460265008257 active site residues [active] 460265008258 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 460265008259 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 460265008260 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 460265008261 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265008262 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 460265008263 active site 460265008264 NTP binding site [chemical binding]; other site 460265008265 metal binding triad [ion binding]; metal-binding site 460265008266 antibiotic binding site [chemical binding]; other site 460265008267 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265008268 TPR repeat; Region: TPR_11; pfam13414 460265008269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265008270 binding surface 460265008271 TPR motif; other site 460265008272 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 460265008273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265008274 binding surface 460265008275 TPR motif; other site 460265008276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265008277 binding surface 460265008278 TPR motif; other site 460265008279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265008280 binding surface 460265008281 TPR motif; other site 460265008282 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 460265008283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265008284 binding surface 460265008285 TPR motif; other site 460265008286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265008287 binding surface 460265008288 TPR motif; other site 460265008289 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 460265008290 Tetratricopeptide repeat; Region: TPR_1; pfam00515 460265008291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265008292 binding surface 460265008293 TPR motif; other site 460265008294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265008295 binding surface 460265008296 TPR motif; other site 460265008297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265008298 binding surface 460265008299 TPR motif; other site 460265008300 Caspase domain; Region: Peptidase_C14; pfam00656 460265008301 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 460265008302 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 460265008303 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265008304 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 460265008305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265008306 Walker A motif; other site 460265008307 ATP binding site [chemical binding]; other site 460265008308 Part of AAA domain; Region: AAA_19; pfam13245 460265008309 Family description; Region: UvrD_C_2; pfam13538 460265008310 MT-A70; Region: MT-A70; cl01947 460265008311 VRR-NUC domain; Region: VRR_NUC; pfam08774 460265008312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265008313 salt bridge; other site 460265008314 non-specific DNA binding site [nucleotide binding]; other site 460265008315 sequence-specific DNA binding site [nucleotide binding]; other site 460265008316 short chain dehydrogenase; Provisional; Region: PRK06701 460265008317 RecT family; Region: RecT; cl04285 460265008318 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 460265008319 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 460265008320 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 460265008321 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 460265008322 tetrameric interface [polypeptide binding]; other site 460265008323 NAD binding site [chemical binding]; other site 460265008324 catalytic residues [active] 460265008325 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265008326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265008327 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265008328 dimerization interface [polypeptide binding]; other site 460265008329 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265008330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265008331 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265008332 dimerization interface [polypeptide binding]; other site 460265008333 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 460265008334 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 460265008335 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265008336 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265008337 putative ligand binding site [chemical binding]; other site 460265008338 Amino acid synthesis; Region: AA_synth; pfam06684 460265008339 Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450 460265008340 PGAP1-like protein; Region: PGAP1; pfam07819 460265008341 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 460265008342 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 460265008343 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 460265008344 active site 460265008345 substrate binding site [chemical binding]; other site 460265008346 Mg2+ binding site [ion binding]; other site 460265008347 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 460265008348 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 460265008349 DNA binding residues [nucleotide binding] 460265008350 dimerization interface [polypeptide binding]; other site 460265008351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265008352 Response regulator receiver domain; Region: Response_reg; pfam00072 460265008353 active site 460265008354 phosphorylation site [posttranslational modification] 460265008355 intermolecular recognition site; other site 460265008356 dimerization interface [polypeptide binding]; other site 460265008357 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 460265008358 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265008359 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 460265008360 putative active site [active] 460265008361 heme pocket [chemical binding]; other site 460265008362 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265008363 putative active site [active] 460265008364 heme pocket [chemical binding]; other site 460265008365 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 460265008366 GAF domain; Region: GAF; pfam01590 460265008367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265008368 dimer interface [polypeptide binding]; other site 460265008369 phosphorylation site [posttranslational modification] 460265008370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265008371 ATP binding site [chemical binding]; other site 460265008372 Mg2+ binding site [ion binding]; other site 460265008373 G-X-G motif; other site 460265008374 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 460265008375 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 460265008376 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 460265008377 Walker A/P-loop; other site 460265008378 ATP binding site [chemical binding]; other site 460265008379 Q-loop/lid; other site 460265008380 ABC transporter signature motif; other site 460265008381 Walker B; other site 460265008382 D-loop; other site 460265008383 H-loop/switch region; other site 460265008384 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 460265008385 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265008386 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265008387 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 460265008388 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265008389 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265008390 catalytic residue [active] 460265008391 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 460265008392 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 460265008393 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 460265008394 flagellin; Validated; Region: PRK08026 460265008395 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 460265008396 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 460265008397 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 460265008398 active site 460265008399 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 460265008400 homodimer interface [polypeptide binding]; other site 460265008401 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 460265008402 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 460265008403 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265008404 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265008405 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265008406 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265008407 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265008408 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 460265008409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 460265008410 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 460265008411 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 460265008412 catalytic motif [active] 460265008413 Catalytic residue [active] 460265008414 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 460265008415 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 460265008416 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 460265008417 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 460265008418 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 460265008419 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 460265008420 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 460265008421 AAA domain; Region: AAA_31; pfam13614 460265008422 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 460265008423 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 460265008424 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 460265008425 ATP binding site [chemical binding]; other site 460265008426 Walker A motif; other site 460265008427 hexamer interface [polypeptide binding]; other site 460265008428 Walker B motif; other site 460265008429 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 460265008430 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 460265008431 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 460265008432 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265008433 TPR motif; other site 460265008434 binding surface 460265008435 TPR repeat; Region: TPR_11; pfam13414 460265008436 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 460265008437 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 460265008438 Ligand binding site; other site 460265008439 Putative Catalytic site; other site 460265008440 DXD motif; other site 460265008441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265008442 S-adenosylmethionine binding site [chemical binding]; other site 460265008443 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 460265008444 Winged helix-turn helix; Region: HTH_29; pfam13551 460265008445 MULE transposase domain; Region: MULE; pfam10551 460265008446 Winged helix-turn helix; Region: HTH_29; pfam13551 460265008447 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 460265008448 active site 460265008449 NTP binding site [chemical binding]; other site 460265008450 metal binding triad [ion binding]; metal-binding site 460265008451 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 460265008452 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 460265008453 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 460265008454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265008455 PAS domain; Region: PAS_9; pfam13426 460265008456 putative active site [active] 460265008457 heme pocket [chemical binding]; other site 460265008458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265008459 ATP binding site [chemical binding]; other site 460265008460 Mg2+ binding site [ion binding]; other site 460265008461 G-X-G motif; other site 460265008462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265008463 active site 460265008464 phosphorylation site [posttranslational modification] 460265008465 intermolecular recognition site; other site 460265008466 dimerization interface [polypeptide binding]; other site 460265008467 Low affinity iron permease; Region: Iron_permease; cl12096 460265008468 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421 460265008469 active site 460265008470 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 460265008471 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 460265008472 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 460265008473 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 460265008474 Catalytic domain of bacteriophage endosialidase; Region: End_tail_spike; pfam12219 460265008475 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 460265008476 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 460265008477 Putative phage tail protein; Region: Phage-tail_3; pfam13550 460265008478 NlpC/P60 family; Region: NLPC_P60; cl17555 460265008479 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 460265008480 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 460265008481 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 460265008482 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 460265008483 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 460265008484 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 460265008485 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 460265008486 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 460265008487 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 460265008488 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 460265008489 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 460265008490 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 460265008491 oligomerization interface [polypeptide binding]; other site 460265008492 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 460265008493 Phage-related protein [Function unknown]; Region: COG4695 460265008494 Phage portal protein; Region: Phage_portal; pfam04860 460265008495 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 460265008496 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 460265008497 Phage capsid family; Region: Phage_capsid; pfam05065 460265008498 Phage Terminase; Region: Terminase_1; pfam03354 460265008499 Phage terminase, small subunit; Region: Terminase_4; pfam05119 460265008500 Transcription termination factor nusG; Region: NusG; pfam02357 460265008501 transcriptional activator RfaH; Region: RfaH; TIGR01955 460265008502 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 460265008503 heterodimer interface [polypeptide binding]; other site 460265008504 homodimer interface [polypeptide binding]; other site 460265008505 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265008506 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 460265008507 polymerase nucleotide-binding site; other site 460265008508 DNA-binding residues [nucleotide binding]; DNA binding site 460265008509 nucleotide binding site [chemical binding]; other site 460265008510 primase nucleotide-binding site [nucleotide binding]; other site 460265008511 Domain of unknown function (DUF927); Region: DUF927; cl12098 460265008512 AAA domain; Region: AAA_30; pfam13604 460265008513 Family description; Region: UvrD_C_2; pfam13538 460265008514 VRR-NUC domain; Region: VRR_NUC; pfam08774 460265008515 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 460265008516 Catalytic site [active] 460265008517 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 460265008518 RecT family; Region: RecT; cl04285 460265008519 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 460265008520 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 460265008521 Domain of unknown function (DUF329); Region: DUF329; cl01144 460265008522 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 460265008523 active site 460265008524 Int/Topo IB signature motif; other site 460265008525 DNA binding site [nucleotide binding] 460265008526 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 460265008527 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 460265008528 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 460265008529 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 460265008530 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 460265008531 Cation efflux family; Region: Cation_efflux; pfam01545 460265008532 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 460265008533 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 460265008534 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265008535 substrate binding pocket [chemical binding]; other site 460265008536 membrane-bound complex binding site; other site 460265008537 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 460265008538 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265008539 substrate binding pocket [chemical binding]; other site 460265008540 membrane-bound complex binding site; other site 460265008541 hinge residues; other site 460265008542 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 460265008543 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 460265008544 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 460265008545 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 460265008546 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 460265008547 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 460265008548 active site 460265008549 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 460265008550 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 460265008551 homodimer interface [polypeptide binding]; other site 460265008552 substrate-cofactor binding pocket; other site 460265008553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265008554 catalytic residue [active] 460265008555 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 460265008556 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 460265008557 active site 460265008558 non-prolyl cis peptide bond; other site 460265008559 Predicted transcriptional regulator [Transcription]; Region: COG1959 460265008560 Transcriptional regulator; Region: Rrf2; pfam02082 460265008561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 460265008562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 460265008563 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 460265008564 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 460265008565 active site 460265008566 non-prolyl cis peptide bond; other site 460265008567 NMT1-like family; Region: NMT1_2; pfam13379 460265008568 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 460265008569 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 460265008570 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 460265008571 Walker A/P-loop; other site 460265008572 ATP binding site [chemical binding]; other site 460265008573 Q-loop/lid; other site 460265008574 ABC transporter signature motif; other site 460265008575 Walker B; other site 460265008576 D-loop; other site 460265008577 H-loop/switch region; other site 460265008578 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 460265008579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265008580 putative PBP binding loops; other site 460265008581 ABC-ATPase subunit interface; other site 460265008582 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 460265008583 catalytic core [active] 460265008584 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 460265008585 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 460265008586 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265008587 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 460265008588 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 460265008589 Coenzyme A transferase; Region: CoA_trans; smart00882 460265008590 Coenzyme A transferase; Region: CoA_trans; cl17247 460265008591 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265008592 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265008593 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265008594 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265008595 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265008596 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265008597 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265008598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 460265008599 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 460265008600 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 460265008601 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 460265008602 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 460265008603 RNA polymerase sigma factor; Provisional; Region: PRK11922 460265008604 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265008605 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 460265008606 DNA binding residues [nucleotide binding] 460265008607 SPW repeat; Region: SPW; pfam03779 460265008608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265008609 putative active site [active] 460265008610 heme pocket [chemical binding]; other site 460265008611 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 460265008612 active site 460265008613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265008614 benzoate transport; Region: 2A0115; TIGR00895 460265008615 putative substrate translocation pore; other site 460265008616 Cytochrome c; Region: Cytochrom_C; cl11414 460265008617 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 460265008618 sulfite oxidase; Provisional; Region: PLN00177 460265008619 Moco binding site; other site 460265008620 metal coordination site [ion binding]; other site 460265008621 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 460265008622 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 460265008623 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 460265008624 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 460265008625 [2Fe-2S] cluster binding site [ion binding]; other site 460265008626 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 460265008627 alpha subunit interface [polypeptide binding]; other site 460265008628 active site 460265008629 substrate binding site [chemical binding]; other site 460265008630 Fe binding site [ion binding]; other site 460265008631 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 460265008632 inter-subunit interface; other site 460265008633 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 460265008634 [2Fe-2S] cluster binding site [ion binding]; other site 460265008635 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 460265008636 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265008637 catalytic loop [active] 460265008638 iron binding site [ion binding]; other site 460265008639 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 460265008640 FAD binding pocket [chemical binding]; other site 460265008641 conserved FAD binding motif [chemical binding]; other site 460265008642 phosphate binding motif [ion binding]; other site 460265008643 beta-alpha-beta structure motif; other site 460265008644 NAD binding pocket [chemical binding]; other site 460265008645 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 460265008646 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265008647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265008648 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 460265008649 dimerization interface [polypeptide binding]; other site 460265008650 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 460265008651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265008652 NAD(P) binding site [chemical binding]; other site 460265008653 active site 460265008654 Transcriptional regulator [Transcription]; Region: IclR; COG1414 460265008655 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 460265008656 Bacterial transcriptional regulator; Region: IclR; pfam01614 460265008657 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 460265008658 PGAP1-like protein; Region: PGAP1; pfam07819 460265008659 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 460265008660 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 460265008661 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 460265008662 classical (c) SDRs; Region: SDR_c; cd05233 460265008663 NAD(P) binding site [chemical binding]; other site 460265008664 active site 460265008665 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 460265008666 classical (c) SDRs; Region: SDR_c; cd05233 460265008667 NAD(P) binding site [chemical binding]; other site 460265008668 active site 460265008669 NIPSNAP; Region: NIPSNAP; pfam07978 460265008670 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265008671 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265008672 putative ligand binding site [chemical binding]; other site 460265008673 putative succinate dehydrogenase; Reviewed; Region: PRK12842 460265008674 Predicted oxidoreductase [General function prediction only]; Region: COG3573 460265008675 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 460265008676 Helix-turn-helix domain; Region: HTH_18; pfam12833 460265008677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265008678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265008679 S-adenosylmethionine binding site [chemical binding]; other site 460265008680 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 460265008681 Predicted membrane protein [Function unknown]; Region: COG2259 460265008682 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 460265008683 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 460265008684 putative metal binding site [ion binding]; other site 460265008685 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 460265008686 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 460265008687 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 460265008688 ABC-ATPase subunit interface; other site 460265008689 dimer interface [polypeptide binding]; other site 460265008690 putative PBP binding regions; other site 460265008691 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 460265008692 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 460265008693 Walker A/P-loop; other site 460265008694 ATP binding site [chemical binding]; other site 460265008695 Q-loop/lid; other site 460265008696 ABC transporter signature motif; other site 460265008697 Walker B; other site 460265008698 D-loop; other site 460265008699 H-loop/switch region; other site 460265008700 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 460265008701 aspartate racemase; Region: asp_race; TIGR00035 460265008702 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265008703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265008704 LysR substrate binding domain; Region: LysR_substrate; pfam03466 460265008705 Methyltransferase domain; Region: Methyltransf_31; pfam13847 460265008706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265008707 S-adenosylmethionine binding site [chemical binding]; other site 460265008708 Tetratricopeptide repeat; Region: TPR_16; pfam13432 460265008709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265008710 TPR motif; other site 460265008711 binding surface 460265008712 Tetratricopeptide repeat; Region: TPR_16; pfam13432 460265008713 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 460265008714 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265008715 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 460265008716 acyl-activating enzyme (AAE) consensus motif; other site 460265008717 AMP binding site [chemical binding]; other site 460265008718 active site 460265008719 CoA binding site [chemical binding]; other site 460265008720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 460265008721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265008722 S-adenosylmethionine binding site [chemical binding]; other site 460265008723 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 460265008724 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 460265008725 DNA binding residues [nucleotide binding] 460265008726 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 460265008727 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 460265008728 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 460265008729 dimer interface [polypeptide binding]; other site 460265008730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265008731 catalytic residue [active] 460265008732 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 460265008733 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 460265008734 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 460265008735 dimer interface [polypeptide binding]; other site 460265008736 decamer (pentamer of dimers) interface [polypeptide binding]; other site 460265008737 catalytic triad [active] 460265008738 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 460265008739 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 460265008740 citrate-proton symporter; Provisional; Region: PRK15075 460265008741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265008742 putative substrate translocation pore; other site 460265008743 CoA binding domain; Region: CoA_binding; cl17356 460265008744 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 460265008745 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 460265008746 active site 460265008747 oxalacetate binding site [chemical binding]; other site 460265008748 citrylCoA binding site [chemical binding]; other site 460265008749 coenzyme A binding site [chemical binding]; other site 460265008750 catalytic triad [active] 460265008751 ATP citrate (pro-S)-lyase; Region: PLN02235 460265008752 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 460265008753 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 460265008754 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 460265008755 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 460265008756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265008757 active site 460265008758 phosphorylation site [posttranslational modification] 460265008759 intermolecular recognition site; other site 460265008760 dimerization interface [polypeptide binding]; other site 460265008761 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265008762 DNA binding site [nucleotide binding] 460265008763 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 460265008764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265008765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265008766 dimer interface [polypeptide binding]; other site 460265008767 phosphorylation site [posttranslational modification] 460265008768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265008769 ATP binding site [chemical binding]; other site 460265008770 Mg2+ binding site [ion binding]; other site 460265008771 G-X-G motif; other site 460265008772 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 460265008773 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 460265008774 catalytic residue [active] 460265008775 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 460265008776 FAD binding domain; Region: FAD_binding_4; pfam01565 460265008777 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 460265008778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265008779 DNA-binding site [nucleotide binding]; DNA binding site 460265008780 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 460265008781 FCD domain; Region: FCD; pfam07729 460265008782 enoyl-CoA hydratase; Provisional; Region: PRK06144 460265008783 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265008784 substrate binding site [chemical binding]; other site 460265008785 oxyanion hole (OAH) forming residues; other site 460265008786 trimer interface [polypeptide binding]; other site 460265008787 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 460265008788 CoA-transferase family III; Region: CoA_transf_3; pfam02515 460265008789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265008790 D-galactonate transporter; Region: 2A0114; TIGR00893 460265008791 putative substrate translocation pore; other site 460265008792 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265008793 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265008794 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265008795 aconitate hydratase; Validated; Region: PRK07229 460265008796 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 460265008797 substrate binding site [chemical binding]; other site 460265008798 ligand binding site [chemical binding]; other site 460265008799 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 460265008800 substrate binding site [chemical binding]; other site 460265008801 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 460265008802 CoA-transferase family III; Region: CoA_transf_3; pfam02515 460265008803 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 460265008804 active site 460265008805 catalytic residues [active] 460265008806 metal binding site [ion binding]; metal-binding site 460265008807 benzoate transport; Region: 2A0115; TIGR00895 460265008808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265008809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265008810 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 460265008811 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 460265008812 C-terminal domain interface [polypeptide binding]; other site 460265008813 GSH binding site (G-site) [chemical binding]; other site 460265008814 dimer interface [polypeptide binding]; other site 460265008815 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 460265008816 N-terminal domain interface [polypeptide binding]; other site 460265008817 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 460265008818 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 460265008819 catalytic site [active] 460265008820 G-X2-G-X-G-K; other site 460265008821 hypothetical protein; Provisional; Region: PRK11820 460265008822 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 460265008823 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 460265008824 YceG-like family; Region: YceG; pfam02618 460265008825 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 460265008826 dimerization interface [polypeptide binding]; other site 460265008827 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 460265008828 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 460265008829 dimer interface [polypeptide binding]; other site 460265008830 active site 460265008831 acyl carrier protein; Provisional; Region: acpP; PRK00982 460265008832 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 460265008833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265008834 NAD(P) binding site [chemical binding]; other site 460265008835 active site 460265008836 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 460265008837 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 460265008838 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 460265008839 Ligand Binding Site [chemical binding]; other site 460265008840 Bacitracin resistance protein BacA; Region: BacA; pfam02673 460265008841 Leucine rich repeat; Region: LRR_8; pfam13855 460265008842 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 460265008843 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 460265008844 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 460265008845 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 460265008846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 460265008847 metal binding site [ion binding]; metal-binding site 460265008848 active site 460265008849 I-site; other site 460265008850 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 460265008851 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 460265008852 PilZ domain; Region: PilZ; pfam07238 460265008853 Isochorismatase family; Region: Isochorismatase; pfam00857 460265008854 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 460265008855 catalytic triad [active] 460265008856 conserved cis-peptide bond; other site 460265008857 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 460265008858 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 460265008859 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 460265008860 serine acetyltransferase; Provisional; Region: cysE; PRK11132 460265008861 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 460265008862 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 460265008863 trimer interface [polypeptide binding]; other site 460265008864 active site 460265008865 substrate binding site [chemical binding]; other site 460265008866 CoA binding site [chemical binding]; other site 460265008867 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 460265008868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265008869 non-specific DNA binding site [nucleotide binding]; other site 460265008870 salt bridge; other site 460265008871 sequence-specific DNA binding site [nucleotide binding]; other site 460265008872 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 460265008873 ADP binding site [chemical binding]; other site 460265008874 magnesium binding site [ion binding]; other site 460265008875 putative shikimate binding site; other site 460265008876 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 460265008877 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 460265008878 dimer interface [polypeptide binding]; other site 460265008879 active site 460265008880 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 460265008881 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265008882 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265008883 catalytic residue [active] 460265008884 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 460265008885 putative active site [active] 460265008886 putative catalytic site [active] 460265008887 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 460265008888 putative active site [active] 460265008889 putative catalytic site [active] 460265008890 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 460265008891 Active_site [active] 460265008892 GTP-binding protein YchF; Reviewed; Region: PRK09601 460265008893 YchF GTPase; Region: YchF; cd01900 460265008894 G1 box; other site 460265008895 GTP/Mg2+ binding site [chemical binding]; other site 460265008896 Switch I region; other site 460265008897 G2 box; other site 460265008898 Switch II region; other site 460265008899 G3 box; other site 460265008900 G4 box; other site 460265008901 G5 box; other site 460265008902 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 460265008903 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 460265008904 putative active site [active] 460265008905 catalytic residue [active] 460265008906 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 460265008907 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 460265008908 5S rRNA interface [nucleotide binding]; other site 460265008909 CTC domain interface [polypeptide binding]; other site 460265008910 L16 interface [polypeptide binding]; other site 460265008911 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 460265008912 catalytic motif [active] 460265008913 Catalytic residue [active] 460265008914 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 460265008915 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 460265008916 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 460265008917 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 460265008918 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 460265008919 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 460265008920 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 460265008921 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 460265008922 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 460265008923 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 460265008924 Type IV pili component [Cell motility and secretion]; Region: COG5461 460265008925 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 460265008926 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 460265008927 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 460265008928 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 460265008929 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 460265008930 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 460265008931 ATP binding site [chemical binding]; other site 460265008932 Walker A motif; other site 460265008933 hexamer interface [polypeptide binding]; other site 460265008934 Walker B motif; other site 460265008935 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 460265008936 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 460265008937 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 460265008938 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 460265008939 E-class dimer interface [polypeptide binding]; other site 460265008940 P-class dimer interface [polypeptide binding]; other site 460265008941 active site 460265008942 Cu2+ binding site [ion binding]; other site 460265008943 Zn2+ binding site [ion binding]; other site 460265008944 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 460265008945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265008946 S-adenosylmethionine binding site [chemical binding]; other site 460265008947 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 460265008948 Uncharacterized conserved protein [Function unknown]; Region: COG2135 460265008949 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 460265008950 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 460265008951 Cl binding site [ion binding]; other site 460265008952 oligomer interface [polypeptide binding]; other site 460265008953 short chain dehydrogenase; Provisional; Region: PRK08278 460265008954 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 460265008955 NAD(P) binding site [chemical binding]; other site 460265008956 homodimer interface [polypeptide binding]; other site 460265008957 active site 460265008958 short chain dehydrogenase; Provisional; Region: PRK08303 460265008959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265008960 NAD(P) binding site [chemical binding]; other site 460265008961 active site 460265008962 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 460265008963 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265008964 substrate binding site [chemical binding]; other site 460265008965 oxyanion hole (OAH) forming residues; other site 460265008966 trimer interface [polypeptide binding]; other site 460265008967 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 460265008968 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 460265008969 active site 460265008970 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 460265008971 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 460265008972 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 460265008973 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 460265008974 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 460265008975 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265008976 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265008977 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265008978 dimerization interface [polypeptide binding]; other site 460265008979 transcription elongation factor regulatory protein; Validated; Region: PRK06342 460265008980 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 460265008981 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 460265008982 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 460265008983 NADP binding site [chemical binding]; other site 460265008984 dimer interface [polypeptide binding]; other site 460265008985 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 460265008986 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 460265008987 pyruvate phosphate dikinase; Provisional; Region: PRK09279 460265008988 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 460265008989 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 460265008990 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 460265008991 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 460265008992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 460265008993 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 460265008994 hypothetical protein; Validated; Region: PRK07586 460265008995 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 460265008996 PYR/PP interface [polypeptide binding]; other site 460265008997 dimer interface [polypeptide binding]; other site 460265008998 TPP binding site [chemical binding]; other site 460265008999 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 460265009000 TPP-binding site [chemical binding]; other site 460265009001 dimer interface [polypeptide binding]; other site 460265009002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 460265009003 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 460265009004 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 460265009005 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 460265009006 dimer interface [polypeptide binding]; other site 460265009007 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265009008 metal binding site [ion binding]; metal-binding site 460265009009 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 460265009010 ketol-acid reductoisomerase; Provisional; Region: PRK05479 460265009011 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 460265009012 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 460265009013 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 460265009014 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 460265009015 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 460265009016 C-terminal domain interface [polypeptide binding]; other site 460265009017 GSH binding site (G-site) [chemical binding]; other site 460265009018 dimer interface [polypeptide binding]; other site 460265009019 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 460265009020 dimer interface [polypeptide binding]; other site 460265009021 N-terminal domain interface [polypeptide binding]; other site 460265009022 substrate binding pocket (H-site) [chemical binding]; other site 460265009023 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 460265009024 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265009025 substrate binding pocket [chemical binding]; other site 460265009026 membrane-bound complex binding site; other site 460265009027 hinge residues; other site 460265009028 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265009029 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 460265009030 active site 460265009031 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 460265009032 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 460265009033 Cu(I) binding site [ion binding]; other site 460265009034 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 460265009035 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 460265009036 ligand binding site [chemical binding]; other site 460265009037 NAD binding site [chemical binding]; other site 460265009038 tetramer interface [polypeptide binding]; other site 460265009039 catalytic site [active] 460265009040 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 460265009041 L-serine binding site [chemical binding]; other site 460265009042 ACT domain interface; other site 460265009043 siroheme synthase; Provisional; Region: cysG; PRK10637 460265009044 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 460265009045 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 460265009046 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 460265009047 active site 460265009048 SAM binding site [chemical binding]; other site 460265009049 homodimer interface [polypeptide binding]; other site 460265009050 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 460265009051 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 460265009052 [4Fe-4S] binding site [ion binding]; other site 460265009053 molybdopterin cofactor binding site; other site 460265009054 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 460265009055 molybdopterin cofactor binding site; other site 460265009056 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 460265009057 sulfite reductase; Provisional; Region: PRK06214 460265009058 Putative Fe-S cluster; Region: FeS; cl17515 460265009059 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 460265009060 FAD binding pocket [chemical binding]; other site 460265009061 FAD binding motif [chemical binding]; other site 460265009062 catalytic residues [active] 460265009063 NAD binding pocket [chemical binding]; other site 460265009064 phosphate binding motif [ion binding]; other site 460265009065 beta-alpha-beta structure motif; other site 460265009066 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 460265009067 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 460265009068 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 460265009069 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 460265009070 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 460265009071 NMT1-like family; Region: NMT1_2; pfam13379 460265009072 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 460265009073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 460265009074 active site 460265009075 phosphorylation site [posttranslational modification] 460265009076 intermolecular recognition site; other site 460265009077 dimerization interface [polypeptide binding]; other site 460265009078 ANTAR domain; Region: ANTAR; pfam03861 460265009079 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 460265009080 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 460265009081 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 460265009082 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 460265009083 TPP-binding site [chemical binding]; other site 460265009084 dimer interface [polypeptide binding]; other site 460265009085 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 460265009086 PYR/PP interface [polypeptide binding]; other site 460265009087 dimer interface [polypeptide binding]; other site 460265009088 TPP binding site [chemical binding]; other site 460265009089 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 460265009090 acetylornithine deacetylase; Provisional; Region: PRK06837 460265009091 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 460265009092 metal binding site [ion binding]; metal-binding site 460265009093 dimer interface [polypeptide binding]; other site 460265009094 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 460265009095 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265009096 active site 460265009097 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 460265009098 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 460265009099 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 460265009100 ATP binding site [chemical binding]; other site 460265009101 putative Mg++ binding site [ion binding]; other site 460265009102 Protein of unknown function (DUF533); Region: DUF533; pfam04391 460265009103 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 460265009104 putative metal binding site [ion binding]; other site 460265009105 septum formation inhibitor; Reviewed; Region: minC; PRK05177 460265009106 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 460265009107 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 460265009108 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 460265009109 Switch I; other site 460265009110 Switch II; other site 460265009111 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 460265009112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265009113 NAD(P) binding site [chemical binding]; other site 460265009114 active site 460265009115 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 460265009116 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 460265009117 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 460265009118 signal recognition particle protein; Provisional; Region: PRK10867 460265009119 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 460265009120 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 460265009121 P loop; other site 460265009122 GTP binding site [chemical binding]; other site 460265009123 Signal peptide binding domain; Region: SRP_SPB; pfam02978 460265009124 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 460265009125 RimM N-terminal domain; Region: RimM; pfam01782 460265009126 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 460265009127 PRC-barrel domain; Region: PRC; pfam05239 460265009128 NAD synthetase; Reviewed; Region: nadE; PRK02628 460265009129 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 460265009130 multimer interface [polypeptide binding]; other site 460265009131 active site 460265009132 catalytic triad [active] 460265009133 protein interface 1 [polypeptide binding]; other site 460265009134 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 460265009135 homodimer interface [polypeptide binding]; other site 460265009136 NAD binding pocket [chemical binding]; other site 460265009137 ATP binding pocket [chemical binding]; other site 460265009138 Mg binding site [ion binding]; other site 460265009139 active-site loop [active] 460265009140 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 460265009141 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 460265009142 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 460265009143 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 460265009144 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 460265009145 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 460265009146 putative catalytic site [active] 460265009147 putative phosphate binding site [ion binding]; other site 460265009148 active site 460265009149 metal binding site A [ion binding]; metal-binding site 460265009150 DNA binding site [nucleotide binding] 460265009151 putative AP binding site [nucleotide binding]; other site 460265009152 putative metal binding site B [ion binding]; other site 460265009153 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 460265009154 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 460265009155 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 460265009156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265009157 NAD(P) binding site [chemical binding]; other site 460265009158 active site 460265009159 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 460265009160 16S/18S rRNA binding site [nucleotide binding]; other site 460265009161 S13e-L30e interaction site [polypeptide binding]; other site 460265009162 25S rRNA binding site [nucleotide binding]; other site 460265009163 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 460265009164 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 460265009165 RNase E interface [polypeptide binding]; other site 460265009166 trimer interface [polypeptide binding]; other site 460265009167 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 460265009168 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 460265009169 RNase E interface [polypeptide binding]; other site 460265009170 trimer interface [polypeptide binding]; other site 460265009171 active site 460265009172 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 460265009173 putative nucleic acid binding region [nucleotide binding]; other site 460265009174 G-X-X-G motif; other site 460265009175 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 460265009176 RNA binding site [nucleotide binding]; other site 460265009177 domain interface; other site 460265009178 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 460265009179 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 460265009180 metal binding site [ion binding]; metal-binding site 460265009181 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 460265009182 Putative phosphatase (DUF442); Region: DUF442; cl17385 460265009183 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 460265009184 Coenzyme A binding pocket [chemical binding]; other site 460265009185 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 460265009186 dimer interface [polypeptide binding]; other site 460265009187 substrate binding site [chemical binding]; other site 460265009188 metal binding sites [ion binding]; metal-binding site 460265009189 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 460265009190 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 460265009191 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 460265009192 putative ligand binding site [chemical binding]; other site 460265009193 NAD binding site [chemical binding]; other site 460265009194 dimerization interface [polypeptide binding]; other site 460265009195 catalytic site [active] 460265009196 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 460265009197 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 460265009198 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 460265009199 NAD(P) binding site [chemical binding]; other site 460265009200 catalytic residues [active] 460265009201 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 460265009202 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 460265009203 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 460265009204 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 460265009205 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 460265009206 hypothetical protein; Provisional; Region: PRK05965 460265009207 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 460265009208 inhibitor-cofactor binding pocket; inhibition site 460265009209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265009210 catalytic residue [active] 460265009211 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 460265009212 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 460265009213 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 460265009214 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 460265009215 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 460265009216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265009217 dimer interface [polypeptide binding]; other site 460265009218 conserved gate region; other site 460265009219 putative PBP binding loops; other site 460265009220 ABC-ATPase subunit interface; other site 460265009221 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 460265009222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265009223 dimer interface [polypeptide binding]; other site 460265009224 conserved gate region; other site 460265009225 ABC-ATPase subunit interface; other site 460265009226 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 460265009227 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265009228 Walker A/P-loop; other site 460265009229 ATP binding site [chemical binding]; other site 460265009230 Q-loop/lid; other site 460265009231 ABC transporter signature motif; other site 460265009232 Walker B; other site 460265009233 D-loop; other site 460265009234 H-loop/switch region; other site 460265009235 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 460265009236 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265009237 Walker A/P-loop; other site 460265009238 ATP binding site [chemical binding]; other site 460265009239 Q-loop/lid; other site 460265009240 ABC transporter signature motif; other site 460265009241 Walker B; other site 460265009242 D-loop; other site 460265009243 H-loop/switch region; other site 460265009244 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 460265009245 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 460265009246 putative DNA binding site [nucleotide binding]; other site 460265009247 putative Zn2+ binding site [ion binding]; other site 460265009248 AsnC family; Region: AsnC_trans_reg; pfam01037 460265009249 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 460265009250 hydroxyglutarate oxidase; Provisional; Region: PRK11728 460265009251 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 460265009252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 460265009253 Coenzyme A binding pocket [chemical binding]; other site 460265009254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 460265009255 hypothetical protein; Validated; Region: PRK09104 460265009256 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 460265009257 metal binding site [ion binding]; metal-binding site 460265009258 putative dimer interface [polypeptide binding]; other site 460265009259 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 460265009260 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 460265009261 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 460265009262 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 460265009263 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 460265009264 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 460265009265 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 460265009266 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265009267 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 460265009268 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 460265009269 metal binding site [ion binding]; metal-binding site 460265009270 putative dimer interface [polypeptide binding]; other site 460265009271 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 460265009272 HIT family signature motif; other site 460265009273 catalytic residue [active] 460265009274 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 460265009275 DEAD-like helicases superfamily; Region: DEXDc; smart00487 460265009276 ATP binding site [chemical binding]; other site 460265009277 putative Mg++ binding site [ion binding]; other site 460265009278 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 460265009279 nucleotide binding region [chemical binding]; other site 460265009280 ATP-binding site [chemical binding]; other site 460265009281 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 460265009282 RNA binding site [nucleotide binding]; other site 460265009283 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 460265009284 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 460265009285 active site 460265009286 Int/Topo IB signature motif; other site 460265009287 DNA binding site [nucleotide binding] 460265009288 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 460265009289 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 460265009290 DNA binding site [nucleotide binding] 460265009291 substrate interaction site [chemical binding]; other site 460265009292 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 460265009293 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 460265009294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265009295 binding surface 460265009296 TPR motif; other site 460265009297 TPR repeat; Region: TPR_11; pfam13414 460265009298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265009299 binding surface 460265009300 TPR motif; other site 460265009301 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 460265009302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265009303 binding surface 460265009304 TPR motif; other site 460265009305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265009306 binding surface 460265009307 TPR motif; other site 460265009308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265009309 binding surface 460265009310 TPR motif; other site 460265009311 TPR repeat; Region: TPR_11; pfam13414 460265009312 TPR repeat; Region: TPR_11; pfam13414 460265009313 Caspase domain; Region: Peptidase_C14; pfam00656 460265009314 nif11-class peptide radical SAM maturase 3; Region: rSAM_nif11_3; TIGR04103 460265009315 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265009316 FeS/SAM binding site; other site 460265009317 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 460265009318 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 460265009319 IHF - DNA interface [nucleotide binding]; other site 460265009320 IHF dimer interface [polypeptide binding]; other site 460265009321 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 460265009322 rod shape-determining protein MreB; Provisional; Region: PRK13930 460265009323 nucleotide binding site [chemical binding]; other site 460265009324 putative NEF/HSP70 interaction site [polypeptide binding]; other site 460265009325 SBD interface [polypeptide binding]; other site 460265009326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265009327 S-adenosylmethionine binding site [chemical binding]; other site 460265009328 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; cl11480 460265009329 Transposase domain (DUF772); Region: DUF772; pfam05598 460265009330 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265009331 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 460265009332 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 460265009333 FMN binding site [chemical binding]; other site 460265009334 substrate binding site [chemical binding]; other site 460265009335 putative catalytic residue [active] 460265009336 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265009337 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265009338 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265009339 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265009340 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265009341 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 460265009342 active site 460265009343 catalytic residues [active] 460265009344 Mechanosensitive ion channel; Region: MS_channel; pfam00924 460265009345 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 460265009346 transcriptional regulator; Provisional; Region: PRK10632 460265009347 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265009348 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 460265009349 putative effector binding pocket; other site 460265009350 dimerization interface [polypeptide binding]; other site 460265009351 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 460265009352 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265009353 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265009354 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 460265009355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265009356 putative substrate translocation pore; other site 460265009357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265009358 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 460265009359 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 460265009360 putative NAD(P) binding site [chemical binding]; other site 460265009361 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 460265009362 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 460265009363 Walker A/P-loop; other site 460265009364 ATP binding site [chemical binding]; other site 460265009365 Q-loop/lid; other site 460265009366 ABC transporter signature motif; other site 460265009367 Walker B; other site 460265009368 D-loop; other site 460265009369 H-loop/switch region; other site 460265009370 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 460265009371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265009372 dimer interface [polypeptide binding]; other site 460265009373 conserved gate region; other site 460265009374 putative PBP binding loops; other site 460265009375 ABC-ATPase subunit interface; other site 460265009376 NMT1/THI5 like; Region: NMT1; pfam09084 460265009377 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265009378 membrane-bound complex binding site; other site 460265009379 Predicted GTPase or GTP-binding protein [General function prediction only]; Region: COG1341 460265009380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 460265009381 Transposase; Region: DDE_Tnp_ISL3; pfam01610 460265009382 Transposase; Region: DDE_Tnp_ISL3; pfam01610 460265009383 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 460265009384 putative deacylase active site [active] 460265009385 Transposase domain (DUF772); Region: DUF772; pfam05598 460265009386 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265009387 Transposase; Region: HTH_Tnp_1; cl17663 460265009388 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265009389 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767 460265009390 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 460265009391 Beta-lactamase; Region: Beta-lactamase; pfam00144 460265009392 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 460265009393 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265009394 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265009395 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 460265009396 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 460265009397 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265009398 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265009399 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 460265009400 Protein export membrane protein; Region: SecD_SecF; cl14618 460265009401 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 460265009402 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cd00598 460265009403 active site 460265009404 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 460265009405 SLBB domain; Region: SLBB; pfam10531 460265009406 GH18 domain of an uncharacterized family of bacterial proteins, which share a common three-domain architecture: an N-terminal glycosyl hydrolase family 18 (GH18) domain, a glycosyl transferase family 2 domain, and a C-terminal polysaccharide deacetylase...; Region: GH18_trifunctional; cd06549 460265009407 putative active site [active] 460265009408 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 460265009409 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 460265009410 NodB motif; other site 460265009411 putative active site [active] 460265009412 putative catalytic site [active] 460265009413 putative Zn binding site [ion binding]; other site 460265009414 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 460265009415 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 460265009416 DXD motif; other site 460265009417 Cellulose synthase-like protein; Region: PLN02893 460265009418 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 460265009419 PAS fold; Region: PAS_7; pfam12860 460265009420 PAS domain; Region: PAS; smart00091 460265009421 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 460265009422 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265009423 putative active site [active] 460265009424 heme pocket [chemical binding]; other site 460265009425 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265009426 dimer interface [polypeptide binding]; other site 460265009427 phosphorylation site [posttranslational modification] 460265009428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265009429 ATP binding site [chemical binding]; other site 460265009430 Mg2+ binding site [ion binding]; other site 460265009431 G-X-G motif; other site 460265009432 Response regulator receiver domain; Region: Response_reg; pfam00072 460265009433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265009434 active site 460265009435 phosphorylation site [posttranslational modification] 460265009436 intermolecular recognition site; other site 460265009437 dimerization interface [polypeptide binding]; other site 460265009438 PAS domain S-box; Region: sensory_box; TIGR00229 460265009439 PAS domain; Region: PAS; smart00091 460265009440 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 460265009441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265009442 putative active site [active] 460265009443 heme pocket [chemical binding]; other site 460265009444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265009445 dimer interface [polypeptide binding]; other site 460265009446 phosphorylation site [posttranslational modification] 460265009447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265009448 ATP binding site [chemical binding]; other site 460265009449 Mg2+ binding site [ion binding]; other site 460265009450 G-X-G motif; other site 460265009451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265009452 active site 460265009453 phosphorylation site [posttranslational modification] 460265009454 intermolecular recognition site; other site 460265009455 dimerization interface [polypeptide binding]; other site 460265009456 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 460265009457 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 460265009458 Protein of unknown function (DUF796); Region: DUF796; pfam05638 460265009459 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 460265009460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265009461 active site 460265009462 phosphorylation site [posttranslational modification] 460265009463 intermolecular recognition site; other site 460265009464 dimerization interface [polypeptide binding]; other site 460265009465 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265009466 DNA binding site [nucleotide binding] 460265009467 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 460265009468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265009469 active site 460265009470 phosphorylation site [posttranslational modification] 460265009471 intermolecular recognition site; other site 460265009472 dimerization interface [polypeptide binding]; other site 460265009473 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265009474 DNA binding site [nucleotide binding] 460265009475 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265009476 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265009477 ligand binding site [chemical binding]; other site 460265009478 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 460265009479 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 460265009480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265009481 Walker A motif; other site 460265009482 ATP binding site [chemical binding]; other site 460265009483 Walker B motif; other site 460265009484 arginine finger; other site 460265009485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265009486 Walker A motif; other site 460265009487 ATP binding site [chemical binding]; other site 460265009488 Walker B motif; other site 460265009489 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 460265009490 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 460265009491 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 460265009492 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 460265009493 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 460265009494 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 460265009495 Protein of unknown function (DUF877); Region: DUF877; pfam05943 460265009496 Protein of unknown function (DUF770); Region: DUF770; pfam05591 460265009497 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 460265009498 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 460265009499 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 460265009500 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 460265009501 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 460265009502 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 460265009503 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 460265009504 phosphopeptide binding site; other site 460265009505 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 460265009506 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 460265009507 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 460265009508 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 460265009509 ligand binding site [chemical binding]; other site 460265009510 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 460265009511 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 460265009512 G1 box; other site 460265009513 GTP/Mg2+ binding site [chemical binding]; other site 460265009514 G2 box; other site 460265009515 Switch I region; other site 460265009516 G3 box; other site 460265009517 Switch II region; other site 460265009518 G4 box; other site 460265009519 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 460265009520 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 460265009521 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 460265009522 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 460265009523 Protein phosphatase 2C; Region: PP2C; pfam00481 460265009524 active site 460265009525 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265009526 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265009527 catalytic residue [active] 460265009528 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 460265009529 Catalytic domain of Protein Kinases; Region: PKc; cd00180 460265009530 active site 460265009531 ATP binding site [chemical binding]; other site 460265009532 substrate binding site [chemical binding]; other site 460265009533 activation loop (A-loop); other site 460265009534 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 460265009535 Uncharacterized conserved protein [Function unknown]; Region: COG1262 460265009536 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 460265009537 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 460265009538 heme-binding site [chemical binding]; other site 460265009539 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265009540 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265009541 cell density-dependent motility repressor; Provisional; Region: PRK10082 460265009542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265009543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 460265009544 dimerization interface [polypeptide binding]; other site 460265009545 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 460265009546 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 460265009547 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 460265009548 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 460265009549 substrate binding site [chemical binding]; other site 460265009550 ligand binding site [chemical binding]; other site 460265009551 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 460265009552 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 460265009553 substrate binding site [chemical binding]; other site 460265009554 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 460265009555 RES domain; Region: RES; smart00953 460265009556 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 460265009557 O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080 460265009558 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 460265009559 homodimer interface [polypeptide binding]; other site 460265009560 substrate-cofactor binding pocket; other site 460265009561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265009562 catalytic residue [active] 460265009563 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 460265009564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265009565 NAD(P) binding site [chemical binding]; other site 460265009566 active site 460265009567 D-lactate dehydrogenase; Provisional; Region: PRK11183 460265009568 FAD binding domain; Region: FAD_binding_4; pfam01565 460265009569 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 460265009570 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 460265009571 trimer interface [polypeptide binding]; other site 460265009572 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 460265009573 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 460265009574 trimer interface [polypeptide binding]; other site 460265009575 putative metal binding site [ion binding]; other site 460265009576 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 460265009577 classical (c) SDRs; Region: SDR_c; cd05233 460265009578 NAD(P) binding site [chemical binding]; other site 460265009579 active site 460265009580 acyl-CoA synthetase; Validated; Region: PRK07470 460265009581 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265009582 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 460265009583 acyl-activating enzyme (AAE) consensus motif; other site 460265009584 acyl-activating enzyme (AAE) consensus motif; other site 460265009585 putative AMP binding site [chemical binding]; other site 460265009586 putative active site [active] 460265009587 putative CoA binding site [chemical binding]; other site 460265009588 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 460265009589 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 460265009590 active site 460265009591 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 460265009592 DctM-like transporters; Region: DctM; pfam06808 460265009593 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 460265009594 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 460265009595 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 460265009596 Transcriptional regulator [Transcription]; Region: IclR; COG1414 460265009597 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 460265009598 Bacterial transcriptional regulator; Region: IclR; pfam01614 460265009599 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 460265009600 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 460265009601 putative DNA binding site [nucleotide binding]; other site 460265009602 putative Zn2+ binding site [ion binding]; other site 460265009603 AsnC family; Region: AsnC_trans_reg; pfam01037 460265009604 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 460265009605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265009606 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 460265009607 putative dimerization interface [polypeptide binding]; other site 460265009608 putative substrate binding pocket [chemical binding]; other site 460265009609 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 460265009610 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 460265009611 glyoxylate carboligase; Provisional; Region: PRK11269 460265009612 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 460265009613 PYR/PP interface [polypeptide binding]; other site 460265009614 dimer interface [polypeptide binding]; other site 460265009615 TPP binding site [chemical binding]; other site 460265009616 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 460265009617 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 460265009618 TPP-binding site [chemical binding]; other site 460265009619 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 460265009620 tartronate semialdehyde reductase; Provisional; Region: PRK15059 460265009621 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 460265009622 pyruvate kinase; Provisional; Region: PRK06247 460265009623 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 460265009624 domain interfaces; other site 460265009625 active site 460265009626 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 460265009627 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 460265009628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265009629 active site 460265009630 phosphorylation site [posttranslational modification] 460265009631 intermolecular recognition site; other site 460265009632 dimerization interface [polypeptide binding]; other site 460265009633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265009634 DNA binding site [nucleotide binding] 460265009635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265009636 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 460265009637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265009638 dimer interface [polypeptide binding]; other site 460265009639 phosphorylation site [posttranslational modification] 460265009640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265009641 Mg2+ binding site [ion binding]; other site 460265009642 G-X-G motif; other site 460265009643 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 460265009644 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 460265009645 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 460265009646 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 460265009647 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 460265009648 FAD binding pocket [chemical binding]; other site 460265009649 FAD binding motif [chemical binding]; other site 460265009650 catalytic residues [active] 460265009651 NAD binding pocket [chemical binding]; other site 460265009652 phosphate binding motif [ion binding]; other site 460265009653 beta-alpha-beta structure motif; other site 460265009654 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 460265009655 ApbE family; Region: ApbE; pfam02424 460265009656 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 460265009657 Transposase; Region: HTH_Tnp_1; cl17663 460265009658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 460265009659 Transposase; Region: DDE_Tnp_ISL3; pfam01610 460265009660 Transposase; Region: DDE_Tnp_ISL3; pfam01610 460265009661 Hemerythrin-like domain; Region: Hr-like; cd12108 460265009662 Fe binding site [ion binding]; other site 460265009663 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 460265009664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265009665 Predicted transcriptional regulators [Transcription]; Region: COG1695 460265009666 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 460265009667 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 460265009668 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 460265009669 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 460265009670 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 460265009671 Ligand Binding Site [chemical binding]; other site 460265009672 muropeptide transporter; Validated; Region: ampG; cl17669 460265009673 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 460265009674 dimerization interface [polypeptide binding]; other site 460265009675 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 460265009676 ligand binding site [chemical binding]; other site 460265009677 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 460265009678 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 460265009679 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 460265009680 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 460265009681 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 460265009682 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 460265009683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265009684 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 460265009685 dimerization interface [polypeptide binding]; other site 460265009686 substrate binding pocket [chemical binding]; other site 460265009687 RNA polymerase sigma factor; Provisional; Region: PRK12547 460265009688 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265009689 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 460265009690 DNA binding residues [nucleotide binding] 460265009691 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265009692 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265009693 putative ligand binding site [chemical binding]; other site 460265009694 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 460265009695 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 460265009696 ligand binding site [chemical binding]; other site 460265009697 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 460265009698 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 460265009699 putative N-terminal domain interface [polypeptide binding]; other site 460265009700 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 460265009701 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 460265009702 dimer interface [polypeptide binding]; other site 460265009703 active site 460265009704 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 460265009705 substrate binding site [chemical binding]; other site 460265009706 catalytic residue [active] 460265009707 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 460265009708 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 460265009709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 460265009710 YheO-like PAS domain; Region: PAS_6; pfam08348 460265009711 HTH domain; Region: HTH_22; pfam13309 460265009712 threonine synthase; Validated; Region: PRK08197 460265009713 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 460265009714 homodimer interface [polypeptide binding]; other site 460265009715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265009716 catalytic residue [active] 460265009717 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 460265009718 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 460265009719 putative active site [active] 460265009720 putative NTP binding site [chemical binding]; other site 460265009721 putative nucleic acid binding site [nucleotide binding]; other site 460265009722 WGR domain of bacterial DNA ligases; Region: WGR_DNA_ligase; cd07998 460265009723 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 460265009724 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 460265009725 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 460265009726 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 460265009727 N-terminal plug; other site 460265009728 ligand-binding site [chemical binding]; other site 460265009729 Recombinase; Region: Recombinase; pfam07508 460265009730 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 460265009731 Predicted transcriptional regulators [Transcription]; Region: COG1733 460265009732 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 460265009733 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 460265009734 Isochorismatase family; Region: Isochorismatase; pfam00857 460265009735 catalytic triad [active] 460265009736 dimer interface [polypeptide binding]; other site 460265009737 conserved cis-peptide bond; other site 460265009738 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 460265009739 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 460265009740 active site 460265009741 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 460265009742 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 460265009743 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 460265009744 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265009745 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265009746 DNA-binding site [nucleotide binding]; DNA binding site 460265009747 FCD domain; Region: FCD; pfam07729 460265009748 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 460265009749 Malonate transporter MadL subunit; Region: MadL; cl04273 460265009750 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 460265009751 Coenzyme A transferase; Region: CoA_trans; cl17247 460265009752 malonate decarboxylase subunit delta; Provisional; Region: PRK02103 460265009753 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 460265009754 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 460265009755 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 460265009756 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 460265009757 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 460265009758 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 460265009759 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 460265009760 hypothetical protein; Provisional; Region: PRK07236 460265009761 Protein of unknown function, DUF485; Region: DUF485; pfam04341 460265009762 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 460265009763 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 460265009764 Na binding site [ion binding]; other site 460265009765 Cupin domain; Region: Cupin_2; cl17218 460265009766 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 460265009767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265009768 putative substrate translocation pore; other site 460265009769 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265009770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265009771 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 460265009772 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 460265009773 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265009774 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 460265009775 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265009776 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265009777 ligand binding site [chemical binding]; other site 460265009778 flexible hinge region; other site 460265009779 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 460265009780 putative switch regulator; other site 460265009781 non-specific DNA interactions [nucleotide binding]; other site 460265009782 DNA binding site [nucleotide binding] 460265009783 sequence specific DNA binding site [nucleotide binding]; other site 460265009784 putative cAMP binding site [chemical binding]; other site 460265009785 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 460265009786 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 460265009787 Probable Catalytic site; other site 460265009788 metal-binding site 460265009789 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 460265009790 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265009791 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 460265009792 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 460265009793 inhibitor-cofactor binding pocket; inhibition site 460265009794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265009795 catalytic residue [active] 460265009796 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265009797 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265009798 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265009799 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265009800 Bacterial sugar transferase; Region: Bac_transf; pfam02397 460265009801 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 460265009802 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265009803 active site 460265009804 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 460265009805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265009806 NAD(P) binding site [chemical binding]; other site 460265009807 active site 460265009808 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 460265009809 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 460265009810 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 460265009811 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 460265009812 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 460265009813 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 460265009814 Probable Catalytic site; other site 460265009815 metal-binding site 460265009816 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 460265009817 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265009818 active site 460265009819 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 460265009820 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265009821 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265009822 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 460265009823 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 460265009824 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 460265009825 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 460265009826 NAD binding site [chemical binding]; other site 460265009827 putative substrate binding site 2 [chemical binding]; other site 460265009828 putative substrate binding site 1 [chemical binding]; other site 460265009829 active site 460265009830 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 460265009831 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 460265009832 NADP-binding site; other site 460265009833 homotetramer interface [polypeptide binding]; other site 460265009834 substrate binding site [chemical binding]; other site 460265009835 homodimer interface [polypeptide binding]; other site 460265009836 active site 460265009837 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 460265009838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265009839 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 460265009840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265009841 active site 460265009842 phosphorylation site [posttranslational modification] 460265009843 intermolecular recognition site; other site 460265009844 dimerization interface [polypeptide binding]; other site 460265009845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265009846 Walker A motif; other site 460265009847 ATP binding site [chemical binding]; other site 460265009848 Walker B motif; other site 460265009849 arginine finger; other site 460265009850 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 460265009851 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 460265009852 dimerization interface [polypeptide binding]; other site 460265009853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265009854 dimer interface [polypeptide binding]; other site 460265009855 phosphorylation site [posttranslational modification] 460265009856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265009857 ATP binding site [chemical binding]; other site 460265009858 Mg2+ binding site [ion binding]; other site 460265009859 G-X-G motif; other site 460265009860 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265009861 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265009862 ligand binding site [chemical binding]; other site 460265009863 flexible hinge region; other site 460265009864 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 460265009865 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 460265009866 nucleophile elbow; other site 460265009867 GAF domain; Region: GAF_2; pfam13185 460265009868 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 460265009869 cyclase homology domain; Region: CHD; cd07302 460265009870 nucleotidyl binding site; other site 460265009871 metal binding site [ion binding]; metal-binding site 460265009872 dimer interface [polypeptide binding]; other site 460265009873 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 460265009874 Iron-sulfur protein interface; other site 460265009875 Transcriptional regulators [Transcription]; Region: MarR; COG1846 460265009876 MarR family; Region: MarR_2; pfam12802 460265009877 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348 460265009878 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 460265009879 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 460265009880 catalytic residue [active] 460265009881 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 460265009882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265009883 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265009884 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265009885 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 460265009886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265009887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265009888 dimerization interface [polypeptide binding]; other site 460265009889 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265009890 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 460265009891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265009892 putative substrate translocation pore; other site 460265009893 KilA-N domain; Region: KilA-N; pfam04383 460265009894 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 460265009895 IHF dimer interface [polypeptide binding]; other site 460265009896 IHF - DNA interface [nucleotide binding]; other site 460265009897 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 460265009898 MarR family; Region: MarR; pfam01047 460265009899 phenol 2-monooxygenase; Provisional; Region: PRK08294 460265009900 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 460265009901 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 460265009902 dimer interface [polypeptide binding]; other site 460265009903 benzoate transport; Region: 2A0115; TIGR00895 460265009904 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 460265009905 two-component response regulator; Provisional; Region: PRK11173 460265009906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265009907 active site 460265009908 phosphorylation site [posttranslational modification] 460265009909 intermolecular recognition site; other site 460265009910 dimerization interface [polypeptide binding]; other site 460265009911 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265009912 DNA binding site [nucleotide binding] 460265009913 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 460265009914 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265009915 dimer interface [polypeptide binding]; other site 460265009916 phosphorylation site [posttranslational modification] 460265009917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265009918 ATP binding site [chemical binding]; other site 460265009919 Mg2+ binding site [ion binding]; other site 460265009920 G-X-G motif; other site 460265009921 Response regulator receiver domain; Region: Response_reg; pfam00072 460265009922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265009923 active site 460265009924 phosphorylation site [posttranslational modification] 460265009925 intermolecular recognition site; other site 460265009926 dimerization interface [polypeptide binding]; other site 460265009927 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 460265009928 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 460265009929 putative ligand binding site [chemical binding]; other site 460265009930 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 460265009931 Recombinase; Region: Recombinase; pfam07508 460265009932 TIGR03118 family protein; Region: PEPCTERM_chp_1 460265009933 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 460265009934 trimer interface [polypeptide binding]; other site 460265009935 active site 460265009936 substrate binding site [chemical binding]; other site 460265009937 CoA binding site [chemical binding]; other site 460265009938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 460265009939 Coenzyme A binding pocket [chemical binding]; other site 460265009940 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 460265009941 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 460265009942 putative active site [active] 460265009943 homoserine dehydrogenase; Provisional; Region: PRK06349 460265009944 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 460265009945 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 460265009946 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 460265009947 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 460265009948 putative catalytic site [active] 460265009949 putative phosphate binding site [ion binding]; other site 460265009950 active site 460265009951 metal binding site A [ion binding]; metal-binding site 460265009952 DNA binding site [nucleotide binding] 460265009953 putative AP binding site [nucleotide binding]; other site 460265009954 putative metal binding site B [ion binding]; other site 460265009955 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 460265009956 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 460265009957 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 460265009958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265009959 dimer interface [polypeptide binding]; other site 460265009960 conserved gate region; other site 460265009961 putative PBP binding loops; other site 460265009962 ABC-ATPase subunit interface; other site 460265009963 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 460265009964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265009965 dimer interface [polypeptide binding]; other site 460265009966 conserved gate region; other site 460265009967 putative PBP binding loops; other site 460265009968 ABC-ATPase subunit interface; other site 460265009969 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 460265009970 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265009971 Walker A/P-loop; other site 460265009972 ATP binding site [chemical binding]; other site 460265009973 Q-loop/lid; other site 460265009974 ABC transporter signature motif; other site 460265009975 Walker B; other site 460265009976 D-loop; other site 460265009977 H-loop/switch region; other site 460265009978 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 460265009979 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265009980 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 460265009981 Walker A/P-loop; other site 460265009982 ATP binding site [chemical binding]; other site 460265009983 Q-loop/lid; other site 460265009984 ABC transporter signature motif; other site 460265009985 Walker B; other site 460265009986 D-loop; other site 460265009987 H-loop/switch region; other site 460265009988 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 460265009989 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 460265009990 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 460265009991 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 460265009992 Cytochrome c; Region: Cytochrom_C; pfam00034 460265009993 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 460265009994 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 460265009995 Transcriptional regulators [Transcription]; Region: FadR; COG2186 460265009996 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265009997 DNA-binding site [nucleotide binding]; DNA binding site 460265009998 FCD domain; Region: FCD; pfam07729 460265009999 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 460265010000 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265010001 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265010002 putative ligand binding site [chemical binding]; other site 460265010003 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 460265010004 Coenzyme A transferase; Region: CoA_trans; smart00882 460265010005 Coenzyme A transferase; Region: CoA_trans; cl17247 460265010006 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 460265010007 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265010008 substrate binding site [chemical binding]; other site 460265010009 oxyanion hole (OAH) forming residues; other site 460265010010 trimer interface [polypeptide binding]; other site 460265010011 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265010012 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265010013 putative ligand binding site [chemical binding]; other site 460265010014 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 460265010015 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 460265010016 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 460265010017 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 460265010018 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 460265010019 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 460265010020 Moco binding site; other site 460265010021 metal coordination site [ion binding]; other site 460265010022 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 460265010023 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265010024 FeS/SAM binding site; other site 460265010025 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 460265010026 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 460265010027 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265010028 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265010029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 460265010030 TPR motif; other site 460265010031 binding surface 460265010032 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 460265010033 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265010034 FeS/SAM binding site; other site 460265010035 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 460265010036 putative ligand binding pocket/active site [active] 460265010037 putative metal binding site [ion binding]; other site 460265010038 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 460265010039 Na binding site [ion binding]; other site 460265010040 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 460265010041 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 460265010042 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 460265010043 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 460265010044 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265010045 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 460265010046 putative hydrophobic ligand binding site [chemical binding]; other site 460265010047 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 460265010048 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 460265010049 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 460265010050 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265010051 catalytic loop [active] 460265010052 iron binding site [ion binding]; other site 460265010053 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 460265010054 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 460265010055 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265010056 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 460265010057 acyl-activating enzyme (AAE) consensus motif; other site 460265010058 acyl-activating enzyme (AAE) consensus motif; other site 460265010059 putative AMP binding site [chemical binding]; other site 460265010060 putative active site [active] 460265010061 putative CoA binding site [chemical binding]; other site 460265010062 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 460265010063 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265010064 substrate binding site [chemical binding]; other site 460265010065 oxyanion hole (OAH) forming residues; other site 460265010066 trimer interface [polypeptide binding]; other site 460265010067 metabolite-proton symporter; Region: 2A0106; TIGR00883 460265010068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265010069 putative substrate translocation pore; other site 460265010070 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 460265010071 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 460265010072 Flavoprotein; Region: Flavoprotein; pfam02441 460265010073 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 460265010074 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 460265010075 catalytic Zn binding site [ion binding]; other site 460265010076 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 460265010077 structural Zn binding site [ion binding]; other site 460265010078 tetramer interface [polypeptide binding]; other site 460265010079 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 460265010080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265010081 Mg2+ binding site [ion binding]; other site 460265010082 G-X-G motif; other site 460265010083 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 460265010084 anchoring element; other site 460265010085 dimer interface [polypeptide binding]; other site 460265010086 ATP binding site [chemical binding]; other site 460265010087 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 460265010088 active site 460265010089 metal binding site [ion binding]; metal-binding site 460265010090 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 460265010091 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 460265010092 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 460265010093 active site 460265010094 interdomain interaction site; other site 460265010095 putative metal-binding site [ion binding]; other site 460265010096 nucleotide binding site [chemical binding]; other site 460265010097 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 460265010098 domain I; other site 460265010099 DNA binding groove [nucleotide binding] 460265010100 phosphate binding site [ion binding]; other site 460265010101 domain II; other site 460265010102 domain III; other site 460265010103 nucleotide binding site [chemical binding]; other site 460265010104 catalytic site [active] 460265010105 domain IV; other site 460265010106 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 460265010107 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 460265010108 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 460265010109 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 460265010110 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 460265010111 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 460265010112 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 460265010113 dihydroorotase; Validated; Region: PRK09059 460265010114 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 460265010115 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 460265010116 active site 460265010117 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 460265010118 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 460265010119 DNA protecting protein DprA; Region: dprA; TIGR00732 460265010120 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 460265010121 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 460265010122 metal-dependent hydrolase; Provisional; Region: PRK00685 460265010123 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 460265010124 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 460265010125 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 460265010126 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 460265010127 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 460265010128 GatB domain; Region: GatB_Yqey; smart00845 460265010129 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 460265010130 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 460265010131 DEAD-like helicases superfamily; Region: DEXDc; smart00487 460265010132 ATP binding site [chemical binding]; other site 460265010133 Mg++ binding site [ion binding]; other site 460265010134 motif III; other site 460265010135 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 460265010136 nucleotide binding region [chemical binding]; other site 460265010137 ATP-binding site [chemical binding]; other site 460265010138 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 460265010139 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 460265010140 metal binding site [ion binding]; metal-binding site 460265010141 active site 460265010142 I-site; other site 460265010143 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 460265010144 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 460265010145 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 460265010146 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 460265010147 Walker A/P-loop; other site 460265010148 ATP binding site [chemical binding]; other site 460265010149 Q-loop/lid; other site 460265010150 ABC transporter signature motif; other site 460265010151 Walker B; other site 460265010152 D-loop; other site 460265010153 H-loop/switch region; other site 460265010154 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 460265010155 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 460265010156 Predicted transcriptional regulators [Transcription]; Region: COG1510 460265010157 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 460265010158 dimerization interface [polypeptide binding]; other site 460265010159 putative DNA binding site [nucleotide binding]; other site 460265010160 putative Zn2+ binding site [ion binding]; other site 460265010161 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 460265010162 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 460265010163 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 460265010164 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 460265010165 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 460265010166 NAD(P) binding site [chemical binding]; other site 460265010167 homoserine O-succinyltransferase; Provisional; Region: PRK05368 460265010168 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 460265010169 conserved cys residue [active] 460265010170 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 460265010171 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 460265010172 homodimer interface [polypeptide binding]; other site 460265010173 substrate-cofactor binding pocket; other site 460265010174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265010175 catalytic residue [active] 460265010176 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 460265010177 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 460265010178 acyl-activating enzyme (AAE) consensus motif; other site 460265010179 putative AMP binding site [chemical binding]; other site 460265010180 putative active site [active] 460265010181 putative CoA binding site [chemical binding]; other site 460265010182 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 460265010183 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 460265010184 CAP-like domain; other site 460265010185 active site 460265010186 primary dimer interface [polypeptide binding]; other site 460265010187 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 460265010188 Recombination protein O N terminal; Region: RecO_N; pfam11967 460265010189 Recombination protein O C terminal; Region: RecO_C; pfam02565 460265010190 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 460265010191 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 460265010192 Domain of unknown function (DUF329); Region: DUF329; pfam03884 460265010193 Maf-like protein; Region: Maf; pfam02545 460265010194 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 460265010195 active site 460265010196 dimer interface [polypeptide binding]; other site 460265010197 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 460265010198 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 460265010199 active site 460265010200 catalytic tetrad [active] 460265010201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265010202 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265010203 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 460265010204 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 460265010205 cytosine deaminase; Provisional; Region: PRK05985 460265010206 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 460265010207 active site 460265010208 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 460265010209 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 460265010210 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 460265010211 FAD binding pocket [chemical binding]; other site 460265010212 FAD binding motif [chemical binding]; other site 460265010213 phosphate binding motif [ion binding]; other site 460265010214 beta-alpha-beta structure motif; other site 460265010215 NAD(p) ribose binding residues [chemical binding]; other site 460265010216 NAD binding pocket [chemical binding]; other site 460265010217 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 460265010218 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265010219 catalytic loop [active] 460265010220 iron binding site [ion binding]; other site 460265010221 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 460265010222 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 460265010223 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 460265010224 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 460265010225 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 460265010226 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 460265010227 PaaX-like protein; Region: PaaX; pfam07848 460265010228 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 460265010229 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 460265010230 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 460265010231 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 460265010232 substrate binding site [chemical binding]; other site 460265010233 dimer interface [polypeptide binding]; other site 460265010234 NADP binding site [chemical binding]; other site 460265010235 catalytic residues [active] 460265010236 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 460265010237 active site 2 [active] 460265010238 active site 1 [active] 460265010239 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265010240 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 460265010241 substrate binding site [chemical binding]; other site 460265010242 oxyanion hole (OAH) forming residues; other site 460265010243 trimer interface [polypeptide binding]; other site 460265010244 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 460265010245 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 460265010246 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 460265010247 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 460265010248 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 460265010249 dimer interface [polypeptide binding]; other site 460265010250 active site 460265010251 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 460265010252 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 460265010253 NAD(P) binding site [chemical binding]; other site 460265010254 catalytic residues [active] 460265010255 enoyl-CoA hydratase; Provisional; Region: PRK08140 460265010256 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265010257 substrate binding site [chemical binding]; other site 460265010258 oxyanion hole (OAH) forming residues; other site 460265010259 trimer interface [polypeptide binding]; other site 460265010260 benzoate transport; Region: 2A0115; TIGR00895 460265010261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265010262 putative substrate translocation pore; other site 460265010263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265010264 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265010265 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 460265010266 CoenzymeA binding site [chemical binding]; other site 460265010267 subunit interaction site [polypeptide binding]; other site 460265010268 PHB binding site; other site 460265010269 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265010270 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 460265010271 acyl-activating enzyme (AAE) consensus motif; other site 460265010272 AMP binding site [chemical binding]; other site 460265010273 active site 460265010274 CoA binding site [chemical binding]; other site 460265010275 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265010276 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265010277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 460265010278 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 460265010279 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 460265010280 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 460265010281 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 460265010282 TPP-binding site [chemical binding]; other site 460265010283 tetramer interface [polypeptide binding]; other site 460265010284 heterodimer interface [polypeptide binding]; other site 460265010285 phosphorylation loop region [posttranslational modification] 460265010286 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 460265010287 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 460265010288 alpha subunit interface [polypeptide binding]; other site 460265010289 TPP binding site [chemical binding]; other site 460265010290 heterodimer interface [polypeptide binding]; other site 460265010291 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 460265010292 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 460265010293 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 460265010294 E3 interaction surface; other site 460265010295 lipoyl attachment site [posttranslational modification]; other site 460265010296 e3 binding domain; Region: E3_binding; pfam02817 460265010297 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 460265010298 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265010299 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265010300 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265010301 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 460265010302 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 460265010303 dimer interface [polypeptide binding]; other site 460265010304 active site residues [active] 460265010305 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 460265010306 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 460265010307 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 460265010308 glutamine synthetase, type I; Region: GlnA; TIGR00653 460265010309 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 460265010310 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 460265010311 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 460265010312 putative deacylase active site [active] 460265010313 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 460265010314 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 460265010315 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 460265010316 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 460265010317 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 460265010318 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 460265010319 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 460265010320 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 460265010321 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 460265010322 hydroxyglutarate oxidase; Provisional; Region: PRK11728 460265010323 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 460265010324 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 460265010325 conserved cys residue [active] 460265010326 Dodecin; Region: Dodecin; pfam07311 460265010327 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 460265010328 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 460265010329 [2Fe-2S] cluster binding site [ion binding]; other site 460265010330 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 460265010331 putative alpha subunit interface [polypeptide binding]; other site 460265010332 putative active site [active] 460265010333 putative substrate binding site [chemical binding]; other site 460265010334 Fe binding site [ion binding]; other site 460265010335 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 460265010336 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 460265010337 FAD binding pocket [chemical binding]; other site 460265010338 FAD binding motif [chemical binding]; other site 460265010339 phosphate binding motif [ion binding]; other site 460265010340 beta-alpha-beta structure motif; other site 460265010341 NAD binding pocket [chemical binding]; other site 460265010342 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265010343 catalytic loop [active] 460265010344 iron binding site [ion binding]; other site 460265010345 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 460265010346 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 460265010347 putative active site [active] 460265010348 putative FMN binding site [chemical binding]; other site 460265010349 putative substrate binding site [chemical binding]; other site 460265010350 putative catalytic residue [active] 460265010351 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 460265010352 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 460265010353 4Fe-4S binding domain; Region: Fer4; cl02805 460265010354 Cysteine-rich domain; Region: CCG; pfam02754 460265010355 Cysteine-rich domain; Region: CCG; pfam02754 460265010356 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 460265010357 Ligand Binding Site [chemical binding]; other site 460265010358 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 460265010359 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 460265010360 Electron transfer flavoprotein domain; Region: ETF; pfam01012 460265010361 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 460265010362 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 460265010363 putative deacylase active site [active] 460265010364 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 460265010365 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 460265010366 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 460265010367 dimer interface [polypeptide binding]; other site 460265010368 active site 460265010369 glycine-pyridoxal phosphate binding site [chemical binding]; other site 460265010370 folate binding site [chemical binding]; other site 460265010371 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 460265010372 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 460265010373 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 460265010374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265010375 dimer interface [polypeptide binding]; other site 460265010376 conserved gate region; other site 460265010377 putative PBP binding loops; other site 460265010378 ABC-ATPase subunit interface; other site 460265010379 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 460265010380 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 460265010381 inhibitor-cofactor binding pocket; inhibition site 460265010382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265010383 catalytic residue [active] 460265010384 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 460265010385 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265010386 non-specific DNA binding site [nucleotide binding]; other site 460265010387 salt bridge; other site 460265010388 sequence-specific DNA binding site [nucleotide binding]; other site 460265010389 Cupin domain; Region: Cupin_2; pfam07883 460265010390 hypothetical protein; Provisional; Region: PRK06486 460265010391 intersubunit interface [polypeptide binding]; other site 460265010392 active site 460265010393 Zn2+ binding site [ion binding]; other site 460265010394 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265010395 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265010396 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 460265010397 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 460265010398 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 460265010399 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 460265010400 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 460265010401 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 460265010402 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 460265010403 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 460265010404 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 460265010405 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 460265010406 Walker A/P-loop; other site 460265010407 ATP binding site [chemical binding]; other site 460265010408 Q-loop/lid; other site 460265010409 ABC transporter signature motif; other site 460265010410 Walker B; other site 460265010411 D-loop; other site 460265010412 H-loop/switch region; other site 460265010413 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 460265010414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265010415 dimer interface [polypeptide binding]; other site 460265010416 conserved gate region; other site 460265010417 putative PBP binding loops; other site 460265010418 ABC-ATPase subunit interface; other site 460265010419 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265010420 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265010421 putative ligand binding site [chemical binding]; other site 460265010422 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 460265010423 classical (c) SDRs; Region: SDR_c; cd05233 460265010424 NAD(P) binding site [chemical binding]; other site 460265010425 active site 460265010426 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265010427 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265010428 Walker A/P-loop; other site 460265010429 ATP binding site [chemical binding]; other site 460265010430 Q-loop/lid; other site 460265010431 ABC transporter signature motif; other site 460265010432 Walker B; other site 460265010433 D-loop; other site 460265010434 H-loop/switch region; other site 460265010435 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265010436 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265010437 Walker A/P-loop; other site 460265010438 ATP binding site [chemical binding]; other site 460265010439 Q-loop/lid; other site 460265010440 ABC transporter signature motif; other site 460265010441 Walker B; other site 460265010442 D-loop; other site 460265010443 H-loop/switch region; other site 460265010444 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265010445 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265010446 TM-ABC transporter signature motif; other site 460265010447 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265010448 TM-ABC transporter signature motif; other site 460265010449 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265010450 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 460265010451 putative ligand binding site [chemical binding]; other site 460265010452 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 460265010453 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 460265010454 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 460265010455 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 460265010456 transcriptional regulator; Provisional; Region: PRK10632 460265010457 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265010458 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 460265010459 putative effector binding pocket; other site 460265010460 dimerization interface [polypeptide binding]; other site 460265010461 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 460265010462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265010463 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265010464 dimerization interface [polypeptide binding]; other site 460265010465 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 460265010466 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 460265010467 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 460265010468 classical (c) SDRs; Region: SDR_c; cd05233 460265010469 NAD(P) binding site [chemical binding]; other site 460265010470 active site 460265010471 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 460265010472 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 460265010473 dimer interface [polypeptide binding]; other site 460265010474 active site 460265010475 catalytic residue [active] 460265010476 metal binding site [ion binding]; metal-binding site 460265010477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 460265010478 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 460265010479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265010480 NAD(P) binding site [chemical binding]; other site 460265010481 active site 460265010482 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 460265010483 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 460265010484 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 460265010485 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 460265010486 iron-sulfur cluster [ion binding]; other site 460265010487 [2Fe-2S] cluster binding site [ion binding]; other site 460265010488 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 460265010489 CHRD domain; Region: CHRD; pfam07452 460265010490 Cupin domain; Region: Cupin_2; pfam07883 460265010491 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 460265010492 cyclase homology domain; Region: CHD; cd07302 460265010493 nucleotidyl binding site; other site 460265010494 metal binding site [ion binding]; metal-binding site 460265010495 dimer interface [polypeptide binding]; other site 460265010496 Predicted integral membrane protein [Function unknown]; Region: COG5616 460265010497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265010498 TPR motif; other site 460265010499 binding surface 460265010500 TPR repeat; Region: TPR_11; pfam13414 460265010501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265010502 TPR motif; other site 460265010503 binding surface 460265010504 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 460265010505 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 460265010506 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 460265010507 putative NAD(P) binding site [chemical binding]; other site 460265010508 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265010509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265010510 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 460265010511 putative effector binding pocket; other site 460265010512 putative dimerization interface [polypeptide binding]; other site 460265010513 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265010514 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 460265010515 Winged helix-turn helix; Region: HTH_29; pfam13551 460265010516 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265010517 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 460265010518 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 460265010519 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 460265010520 P-loop; other site 460265010521 Magnesium ion binding site [ion binding]; other site 460265010522 cyclase homology domain; Region: CHD; cd07302 460265010523 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 460265010524 nucleotidyl binding site; other site 460265010525 metal binding site [ion binding]; metal-binding site 460265010526 dimer interface [polypeptide binding]; other site 460265010527 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 460265010528 PRC-barrel domain; Region: PRC; pfam05239 460265010529 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 460265010530 Uncharacterized conserved protein [Function unknown]; Region: COG1615 460265010531 Epoxide hydrolase N terminus; Region: EHN; pfam06441 460265010532 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 460265010533 PGAP1-like protein; Region: PGAP1; pfam07819 460265010534 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265010535 non-specific DNA binding site [nucleotide binding]; other site 460265010536 salt bridge; other site 460265010537 sequence-specific DNA binding site [nucleotide binding]; other site 460265010538 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 460265010539 Predicted membrane protein [Function unknown]; Region: COG4244 460265010540 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 460265010541 CoA-transferase family III; Region: CoA_transf_3; pfam02515 460265010542 enoyl-CoA hydratase; Provisional; Region: PRK06494 460265010543 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265010544 substrate binding site [chemical binding]; other site 460265010545 oxyanion hole (OAH) forming residues; other site 460265010546 trimer interface [polypeptide binding]; other site 460265010547 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 460265010548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265010549 NAD(P) binding site [chemical binding]; other site 460265010550 active site 460265010551 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 460265010552 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 460265010553 active site 460265010554 DUF35 OB-fold domain; Region: DUF35; pfam01796 460265010555 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 460265010556 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265010557 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 460265010558 dimerization interface [polypeptide binding]; other site 460265010559 substrate binding pocket [chemical binding]; other site 460265010560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265010561 metabolite-proton symporter; Region: 2A0106; TIGR00883 460265010562 putative substrate translocation pore; other site 460265010563 selenophosphate synthetase; Provisional; Region: PRK00943 460265010564 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 460265010565 dimerization interface [polypeptide binding]; other site 460265010566 putative ATP binding site [chemical binding]; other site 460265010567 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 460265010568 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 460265010569 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 460265010570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265010571 FeS/SAM binding site; other site 460265010572 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 460265010573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 460265010574 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 460265010575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265010576 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 460265010577 Walker A/P-loop; other site 460265010578 ATP binding site [chemical binding]; other site 460265010579 Q-loop/lid; other site 460265010580 ABC transporter signature motif; other site 460265010581 Walker B; other site 460265010582 D-loop; other site 460265010583 H-loop/switch region; other site 460265010584 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 460265010585 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 460265010586 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 460265010587 dimer interface [polypeptide binding]; other site 460265010588 putative CheW interface [polypeptide binding]; other site 460265010589 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 460265010590 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 460265010591 PAS domain S-box; Region: sensory_box; TIGR00229 460265010592 PAS domain; Region: PAS_8; pfam13188 460265010593 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 460265010594 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 460265010595 metal binding site [ion binding]; metal-binding site 460265010596 active site 460265010597 I-site; other site 460265010598 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 460265010599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265010600 TPR motif; other site 460265010601 TPR repeat; Region: TPR_11; pfam13414 460265010602 binding surface 460265010603 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 460265010604 HTH-like domain; Region: HTH_21; pfam13276 460265010605 Integrase core domain; Region: rve; pfam00665 460265010606 Integrase core domain; Region: rve_3; pfam13683 460265010607 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265010608 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265010609 Domain of unknown function (DUF4313); Region: DUF4313; pfam14190 460265010610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265010611 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 460265010612 putative active site [active] 460265010613 heme pocket [chemical binding]; other site 460265010614 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265010615 putative active site [active] 460265010616 heme pocket [chemical binding]; other site 460265010617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265010618 ATP binding site [chemical binding]; other site 460265010619 Mg2+ binding site [ion binding]; other site 460265010620 G-X-G motif; other site 460265010621 Response regulator receiver domain; Region: Response_reg; pfam00072 460265010622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265010623 active site 460265010624 phosphorylation site [posttranslational modification] 460265010625 intermolecular recognition site; other site 460265010626 dimerization interface [polypeptide binding]; other site 460265010627 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 460265010628 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 460265010629 catalytic residue [active] 460265010630 Phage-related protein, tail component [Function unknown]; Region: COG4733 460265010631 Putative phage tail protein; Region: Phage-tail_3; pfam13550 460265010632 Fibronectin type 3 domain; Region: FN3; smart00060 460265010633 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 460265010634 Phage-related protein, tail component [Function unknown]; Region: COG4723 460265010635 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 460265010636 Phage minor tail protein L; Region: Phage_tail_L; cl01908 460265010637 Phage minor tail protein; Region: Phage_min_tail; cl01940 460265010638 Phage-related minor tail protein [Function unknown]; Region: COG5281 460265010639 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 460265010640 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 460265010641 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265010642 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265010643 catalytic residue [active] 460265010644 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 460265010645 Predicted transcriptional regulator [Transcription]; Region: COG2944 460265010646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265010647 non-specific DNA binding site [nucleotide binding]; other site 460265010648 salt bridge; other site 460265010649 sequence-specific DNA binding site [nucleotide binding]; other site 460265010650 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 460265010651 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 460265010652 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 460265010653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 460265010654 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 460265010655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566 460265010656 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 460265010657 Winged helix-turn helix; Region: HTH_29; pfam13551 460265010658 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265010659 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 460265010660 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265010661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 460265010662 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 460265010663 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 460265010664 hypothetical protein; Provisional; Region: 57B; PHA02574 460265010665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 460265010666 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 460265010667 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP); Region: NGN_SP; cd09886 460265010668 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 460265010669 heterodimer interface [polypeptide binding]; other site 460265010670 homodimer interface [polypeptide binding]; other site 460265010671 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265010672 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 460265010673 putative active site [active] 460265010674 replicative DNA helicase; Provisional; Region: PRK09165 460265010675 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 460265010676 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 460265010677 ATP binding site [chemical binding]; other site 460265010678 Walker A motif; other site 460265010679 Walker B motif; other site 460265010680 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265010681 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265010682 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265010683 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265010684 NUMOD4 motif; Region: NUMOD4; pfam07463 460265010685 HNH endonuclease; Region: HNH_3; pfam13392 460265010686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265010687 non-specific DNA binding site [nucleotide binding]; other site 460265010688 salt bridge; other site 460265010689 sequence-specific DNA binding site [nucleotide binding]; other site 460265010690 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 460265010691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265010692 non-specific DNA binding site [nucleotide binding]; other site 460265010693 salt bridge; other site 460265010694 sequence-specific DNA binding site [nucleotide binding]; other site 460265010695 Predicted transcriptional regulator [Transcription]; Region: COG2932 460265010696 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 460265010697 Catalytic site [active] 460265010698 Methyltransferase domain; Region: Methyltransf_26; pfam13659 460265010699 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 460265010700 active site 460265010701 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 460265010702 RecT family; Region: RecT; cl04285 460265010703 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 460265010704 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 460265010705 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 460265010706 cofactor binding site; other site 460265010707 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 460265010708 DNA binding site [nucleotide binding] 460265010709 substrate interaction site [chemical binding]; other site 460265010710 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 460265010711 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 460265010712 Helix-turn-helix domain; Region: HTH_17; pfam12728 460265010713 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 460265010714 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 460265010715 active site 460265010716 Int/Topo IB signature motif; other site 460265010717 Response regulator receiver domain; Region: Response_reg; pfam00072 460265010718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265010719 active site 460265010720 phosphorylation site [posttranslational modification] 460265010721 intermolecular recognition site; other site 460265010722 dimerization interface [polypeptide binding]; other site 460265010723 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 460265010724 FHIPEP family; Region: FHIPEP; pfam00771 460265010725 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 460265010726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265010727 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265010728 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265010729 Methyltransferase domain; Region: Methyltransf_24; pfam13578 460265010730 Predicted integral membrane protein [Function unknown]; Region: COG0392 460265010731 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 460265010732 Serine hydrolase; Region: Ser_hydrolase; cl17834 460265010733 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 460265010734 Coenzyme A binding pocket [chemical binding]; other site 460265010735 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 460265010736 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 460265010737 Walker A motif; other site 460265010738 ATP binding site [chemical binding]; other site 460265010739 Walker B motif; other site 460265010740 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 460265010741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265010742 active site 460265010743 phosphorylation site [posttranslational modification] 460265010744 intermolecular recognition site; other site 460265010745 dimerization interface [polypeptide binding]; other site 460265010746 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265010747 DNA binding site [nucleotide binding] 460265010748 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 460265010749 PBP superfamily domain; Region: PBP_like_2; pfam12849 460265010750 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 460265010751 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 460265010752 Walker A/P-loop; other site 460265010753 ATP binding site [chemical binding]; other site 460265010754 Q-loop/lid; other site 460265010755 ABC transporter signature motif; other site 460265010756 Walker B; other site 460265010757 D-loop; other site 460265010758 H-loop/switch region; other site 460265010759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 460265010760 dimer interface [polypeptide binding]; other site 460265010761 conserved gate region; other site 460265010762 manganese transport regulator MntR; Provisional; Region: PRK11050 460265010763 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 460265010764 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 460265010765 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 460265010766 putative active site [active] 460265010767 putative catalytic site [active] 460265010768 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 460265010769 putative active site [active] 460265010770 putative catalytic site [active] 460265010771 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 460265010772 YGGT family; Region: YGGT; pfam02325 460265010773 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 460265010774 PAS fold; Region: PAS_4; pfam08448 460265010775 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 460265010776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265010777 putative active site [active] 460265010778 heme pocket [chemical binding]; other site 460265010779 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265010780 putative active site [active] 460265010781 heme pocket [chemical binding]; other site 460265010782 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265010783 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 460265010784 putative active site [active] 460265010785 heme pocket [chemical binding]; other site 460265010786 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265010787 dimer interface [polypeptide binding]; other site 460265010788 phosphorylation site [posttranslational modification] 460265010789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265010790 ATP binding site [chemical binding]; other site 460265010791 Mg2+ binding site [ion binding]; other site 460265010792 G-X-G motif; other site 460265010793 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 460265010794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265010795 active site 460265010796 phosphorylation site [posttranslational modification] 460265010797 intermolecular recognition site; other site 460265010798 dimerization interface [polypeptide binding]; other site 460265010799 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 460265010800 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 460265010801 active site 460265010802 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 460265010803 CoA-transferase family III; Region: CoA_transf_3; pfam02515 460265010804 Putative zinc-finger; Region: zf-HC2; pfam13490 460265010805 RNA polymerase sigma factor; Provisional; Region: PRK11922 460265010806 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265010807 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 460265010808 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 460265010809 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 460265010810 active site 460265010811 Zn binding site [ion binding]; other site 460265010812 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 460265010813 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 460265010814 putative C-terminal domain interface [polypeptide binding]; other site 460265010815 putative GSH binding site (G-site) [chemical binding]; other site 460265010816 putative dimer interface [polypeptide binding]; other site 460265010817 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 460265010818 dimer interface [polypeptide binding]; other site 460265010819 N-terminal domain interface [polypeptide binding]; other site 460265010820 putative substrate binding pocket (H-site) [chemical binding]; other site 460265010821 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 460265010822 metal binding site [ion binding]; metal-binding site 460265010823 active site 460265010824 I-site; other site 460265010825 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 460265010826 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 460265010827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265010828 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265010829 dimerization interface [polypeptide binding]; other site 460265010830 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 460265010831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265010832 Walker A/P-loop; other site 460265010833 ATP binding site [chemical binding]; other site 460265010834 Q-loop/lid; other site 460265010835 ABC transporter signature motif; other site 460265010836 Walker B; other site 460265010837 D-loop; other site 460265010838 H-loop/switch region; other site 460265010839 TOBE domain; Region: TOBE_2; pfam08402 460265010840 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 460265010841 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 460265010842 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 460265010843 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 460265010844 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 460265010845 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 460265010846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265010847 dimer interface [polypeptide binding]; other site 460265010848 conserved gate region; other site 460265010849 putative PBP binding loops; other site 460265010850 ABC-ATPase subunit interface; other site 460265010851 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 460265010852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265010853 ABC-ATPase subunit interface; other site 460265010854 acetylornithine deacetylase; Provisional; Region: PRK07522 460265010855 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 460265010856 metal binding site [ion binding]; metal-binding site 460265010857 putative dimer interface [polypeptide binding]; other site 460265010858 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 460265010859 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 460265010860 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265010861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265010862 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265010863 dimerization interface [polypeptide binding]; other site 460265010864 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 460265010865 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 460265010866 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 460265010867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265010868 dimer interface [polypeptide binding]; other site 460265010869 conserved gate region; other site 460265010870 putative PBP binding loops; other site 460265010871 ABC-ATPase subunit interface; other site 460265010872 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 460265010873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265010874 ABC-ATPase subunit interface; other site 460265010875 putative PBP binding loops; other site 460265010876 hypothetical protein; Provisional; Region: PRK07079 460265010877 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 460265010878 metal binding site [ion binding]; metal-binding site 460265010879 putative dimer interface [polypeptide binding]; other site 460265010880 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 460265010881 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265010882 Walker A/P-loop; other site 460265010883 ATP binding site [chemical binding]; other site 460265010884 Q-loop/lid; other site 460265010885 ABC transporter signature motif; other site 460265010886 Walker B; other site 460265010887 D-loop; other site 460265010888 H-loop/switch region; other site 460265010889 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 460265010890 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265010891 Walker A/P-loop; other site 460265010892 ATP binding site [chemical binding]; other site 460265010893 Q-loop/lid; other site 460265010894 ABC transporter signature motif; other site 460265010895 Walker B; other site 460265010896 D-loop; other site 460265010897 H-loop/switch region; other site 460265010898 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 460265010899 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 460265010900 MarR family; Region: MarR_2; pfam12802 460265010901 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 460265010902 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 460265010903 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 460265010904 Low molecular weight phosphatase family; Region: LMWPc; cd00115 460265010905 active site 460265010906 Fructosamine kinase; Region: Fructosamin_kin; cl17579 460265010907 Phosphotransferase enzyme family; Region: APH; pfam01636 460265010908 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 460265010909 Zn2+ binding site [ion binding]; other site 460265010910 Mg2+ binding site [ion binding]; other site 460265010911 mercuric reductase; Validated; Region: PRK06370 460265010912 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 460265010913 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 460265010914 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 460265010915 Predicted membrane protein [Function unknown]; Region: COG3918 460265010916 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 460265010917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265010918 dimer interface [polypeptide binding]; other site 460265010919 conserved gate region; other site 460265010920 ABC-ATPase subunit interface; other site 460265010921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265010922 dimer interface [polypeptide binding]; other site 460265010923 conserved gate region; other site 460265010924 putative PBP binding loops; other site 460265010925 ABC-ATPase subunit interface; other site 460265010926 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 460265010927 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265010928 substrate binding pocket [chemical binding]; other site 460265010929 membrane-bound complex binding site; other site 460265010930 hinge residues; other site 460265010931 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 460265010932 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 460265010933 Walker A/P-loop; other site 460265010934 ATP binding site [chemical binding]; other site 460265010935 Q-loop/lid; other site 460265010936 ABC transporter signature motif; other site 460265010937 Walker B; other site 460265010938 D-loop; other site 460265010939 H-loop/switch region; other site 460265010940 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 460265010941 EamA-like transporter family; Region: EamA; pfam00892 460265010942 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 460265010943 substrate binding site [chemical binding]; other site 460265010944 Replication initiator protein A; Region: RPA; pfam10134 460265010945 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265010946 cell density-dependent motility repressor; Provisional; Region: PRK10082 460265010947 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265010948 LysR substrate binding domain; Region: LysR_substrate; pfam03466 460265010949 dimerization interface [polypeptide binding]; other site 460265010950 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 460265010951 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 460265010952 putative active site pocket [active] 460265010953 metal binding site [ion binding]; metal-binding site 460265010954 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 460265010955 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 460265010956 Citrate transporter; Region: CitMHS; pfam03600 460265010957 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265010958 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265010959 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 460265010960 putative dimerization interface [polypeptide binding]; other site 460265010961 DEAD-like helicases superfamily; Region: DEXDc; smart00487 460265010962 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 460265010963 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 460265010964 putative Mg++ binding site [ion binding]; other site 460265010965 nucleotide binding region [chemical binding]; other site 460265010966 helicase superfamily c-terminal domain; Region: HELICc; smart00490 460265010967 ATP-binding site [chemical binding]; other site 460265010968 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 460265010969 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 460265010970 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 460265010971 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265010972 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265010973 TM-ABC transporter signature motif; other site 460265010974 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265010975 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265010976 Walker A/P-loop; other site 460265010977 ATP binding site [chemical binding]; other site 460265010978 Q-loop/lid; other site 460265010979 ABC transporter signature motif; other site 460265010980 Walker B; other site 460265010981 D-loop; other site 460265010982 H-loop/switch region; other site 460265010983 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265010984 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265010985 Walker A/P-loop; other site 460265010986 ATP binding site [chemical binding]; other site 460265010987 Q-loop/lid; other site 460265010988 ABC transporter signature motif; other site 460265010989 Walker B; other site 460265010990 D-loop; other site 460265010991 H-loop/switch region; other site 460265010992 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265010993 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 460265010994 TM-ABC transporter signature motif; other site 460265010995 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265010996 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265010997 putative ligand binding site [chemical binding]; other site 460265010998 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265010999 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265011000 DNA-binding site [nucleotide binding]; DNA binding site 460265011001 FCD domain; Region: FCD; pfam07729 460265011002 short chain dehydrogenase; Provisional; Region: PRK12829 460265011003 classical (c) SDRs; Region: SDR_c; cd05233 460265011004 NAD(P) binding site [chemical binding]; other site 460265011005 active site 460265011006 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 460265011007 active site 460265011008 ATP binding site [chemical binding]; other site 460265011009 substrate binding site [chemical binding]; other site 460265011010 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 460265011011 Uncharacterized conserved protein [Function unknown]; Region: COG2128 460265011012 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 460265011013 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265011014 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 460265011015 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 460265011016 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 460265011017 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 460265011018 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265011019 DNA-binding site [nucleotide binding]; DNA binding site 460265011020 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 460265011021 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 460265011022 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 460265011023 allantoate amidohydrolase; Reviewed; Region: PRK12892 460265011024 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 460265011025 active site 460265011026 metal binding site [ion binding]; metal-binding site 460265011027 dimer interface [polypeptide binding]; other site 460265011028 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 460265011029 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 460265011030 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 460265011031 GIY-YIG motif/motif A; other site 460265011032 active site 460265011033 catalytic site [active] 460265011034 putative DNA binding site [nucleotide binding]; other site 460265011035 metal binding site [ion binding]; metal-binding site 460265011036 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 460265011037 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 460265011038 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 460265011039 MoaE interaction surface [polypeptide binding]; other site 460265011040 MoeB interaction surface [polypeptide binding]; other site 460265011041 thiocarboxylated glycine; other site 460265011042 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 460265011043 Predicted membrane protein [Function unknown]; Region: COG2855 460265011044 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 460265011045 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 460265011046 active site 460265011047 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 460265011048 Predicted acetyltransferase [General function prediction only]; Region: COG2388 460265011049 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 460265011050 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 460265011051 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 460265011052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265011053 putative PBP binding loops; other site 460265011054 ABC-ATPase subunit interface; other site 460265011055 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 460265011056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265011057 Walker A/P-loop; other site 460265011058 ATP binding site [chemical binding]; other site 460265011059 Q-loop/lid; other site 460265011060 ABC transporter signature motif; other site 460265011061 Walker B; other site 460265011062 D-loop; other site 460265011063 H-loop/switch region; other site 460265011064 TOBE domain; Region: TOBE; cl01440 460265011065 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 460265011066 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 460265011067 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 460265011068 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 460265011069 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 460265011070 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 460265011071 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 460265011072 succinic semialdehyde dehydrogenase; Region: PLN02278 460265011073 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 460265011074 tetramerization interface [polypeptide binding]; other site 460265011075 NAD(P) binding site [chemical binding]; other site 460265011076 catalytic residues [active] 460265011077 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 460265011078 ParB-like nuclease domain; Region: ParBc; pfam02195 460265011079 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 460265011080 MerR family regulatory protein; Region: MerR; pfam00376 460265011081 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 460265011082 P-loop; other site 460265011083 Magnesium ion binding site [ion binding]; other site 460265011084 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 460265011085 Magnesium ion binding site [ion binding]; other site 460265011086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 460265011087 TPR motif; other site 460265011088 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 460265011089 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 460265011090 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 460265011091 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 460265011092 DXD motif; other site 460265011093 Response regulator receiver domain; Region: Response_reg; pfam00072 460265011094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265011095 active site 460265011096 phosphorylation site [posttranslational modification] 460265011097 intermolecular recognition site; other site 460265011098 dimerization interface [polypeptide binding]; other site 460265011099 amidase; Provisional; Region: PRK07056 460265011100 amidase; Validated; Region: PRK05962 460265011101 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265011102 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265011103 DNA-binding site [nucleotide binding]; DNA binding site 460265011104 FCD domain; Region: FCD; pfam07729 460265011105 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 460265011106 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 460265011107 NAD(P) binding site [chemical binding]; other site 460265011108 acetolactate synthase catalytic subunit; Validated; Region: PRK06112 460265011109 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 460265011110 PYR/PP interface [polypeptide binding]; other site 460265011111 dimer interface [polypeptide binding]; other site 460265011112 TPP binding site [chemical binding]; other site 460265011113 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 460265011114 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 460265011115 TPP-binding site [chemical binding]; other site 460265011116 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 460265011117 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 460265011118 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265011119 TM-ABC transporter signature motif; other site 460265011120 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265011121 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265011122 TM-ABC transporter signature motif; other site 460265011123 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265011124 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265011125 Walker A/P-loop; other site 460265011126 ATP binding site [chemical binding]; other site 460265011127 Q-loop/lid; other site 460265011128 ABC transporter signature motif; other site 460265011129 Walker B; other site 460265011130 D-loop; other site 460265011131 H-loop/switch region; other site 460265011132 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265011133 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265011134 Walker A/P-loop; other site 460265011135 ATP binding site [chemical binding]; other site 460265011136 Q-loop/lid; other site 460265011137 ABC transporter signature motif; other site 460265011138 Walker B; other site 460265011139 D-loop; other site 460265011140 H-loop/switch region; other site 460265011141 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 460265011142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265011143 NAD(P) binding site [chemical binding]; other site 460265011144 active site 460265011145 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 460265011146 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 460265011147 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 460265011148 shikimate binding site; other site 460265011149 NAD(P) binding site [chemical binding]; other site 460265011150 choline dehydrogenase; Validated; Region: PRK02106 460265011151 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 460265011152 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 460265011153 CheB methylesterase; Region: CheB_methylest; pfam01339 460265011154 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 460265011155 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 460265011156 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 460265011157 IncA protein; Region: IncA; pfam04156 460265011158 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 460265011159 PAS domain; Region: PAS_10; pfam13596 460265011160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 460265011161 HWE histidine kinase; Region: HWE_HK; smart00911 460265011162 CheB methylesterase; Region: CheB_methylest; pfam01339 460265011163 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 460265011164 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265011165 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265011166 ligand binding site [chemical binding]; other site 460265011167 flexible hinge region; other site 460265011168 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 460265011169 putative switch regulator; other site 460265011170 non-specific DNA interactions [nucleotide binding]; other site 460265011171 DNA binding site [nucleotide binding] 460265011172 sequence specific DNA binding site [nucleotide binding]; other site 460265011173 putative cAMP binding site [chemical binding]; other site 460265011174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265011175 active site 460265011176 phosphorylation site [posttranslational modification] 460265011177 intermolecular recognition site; other site 460265011178 dimerization interface [polypeptide binding]; other site 460265011179 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 460265011180 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 460265011181 active site 460265011182 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 460265011183 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 460265011184 FMN binding site [chemical binding]; other site 460265011185 active site 460265011186 catalytic residues [active] 460265011187 substrate binding site [chemical binding]; other site 460265011188 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 460265011189 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 460265011190 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 460265011191 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 460265011192 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 460265011193 catalytic motif [active] 460265011194 Catalytic residue [active] 460265011195 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 460265011196 cobalamin synthase; Reviewed; Region: cobS; PRK00235 460265011197 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 460265011198 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 460265011199 putative dimer interface [polypeptide binding]; other site 460265011200 active site pocket [active] 460265011201 putative cataytic base [active] 460265011202 enterobactin exporter EntS; Provisional; Region: PRK10489 460265011203 Protein of unknown function (DUF563); Region: DUF563; pfam04577 460265011204 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 460265011205 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265011206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265011207 active site 460265011208 phosphorylation site [posttranslational modification] 460265011209 intermolecular recognition site; other site 460265011210 dimerization interface [polypeptide binding]; other site 460265011211 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265011212 DNA binding residues [nucleotide binding] 460265011213 CHASE3 domain; Region: CHASE3; pfam05227 460265011214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265011215 dimer interface [polypeptide binding]; other site 460265011216 phosphorylation site [posttranslational modification] 460265011217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265011218 ATP binding site [chemical binding]; other site 460265011219 Mg2+ binding site [ion binding]; other site 460265011220 G-X-G motif; other site 460265011221 Response regulator receiver domain; Region: Response_reg; pfam00072 460265011222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265011223 active site 460265011224 phosphorylation site [posttranslational modification] 460265011225 intermolecular recognition site; other site 460265011226 dimerization interface [polypeptide binding]; other site 460265011227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265011228 TPR motif; other site 460265011229 binding surface 460265011230 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 460265011231 TadE-like protein; Region: TadE; pfam07811 460265011232 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 460265011233 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 460265011234 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 460265011235 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 460265011236 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 460265011237 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 460265011238 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 460265011239 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 460265011240 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 460265011241 ATP binding site [chemical binding]; other site 460265011242 Walker A motif; other site 460265011243 hexamer interface [polypeptide binding]; other site 460265011244 Walker B motif; other site 460265011245 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 460265011246 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 460265011247 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 460265011248 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 460265011249 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 460265011250 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 460265011251 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 460265011252 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 460265011253 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 460265011254 active site 460265011255 DNA binding site [nucleotide binding] 460265011256 Int/Topo IB signature motif; other site 460265011257 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 460265011258 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 460265011259 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 460265011260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265011261 sequence-specific DNA binding site [nucleotide binding]; other site 460265011262 salt bridge; other site 460265011263 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 460265011264 ERF superfamily; Region: ERF; pfam04404 460265011265 Predicted transcriptional regulator [Transcription]; Region: COG2932 460265011266 Helix-turn-helix; Region: HTH_3; pfam01381 460265011267 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 460265011268 Catalytic site [active] 460265011269 ThiC family; Region: ThiC; cl08031 460265011270 VRR-NUC domain; Region: VRR_NUC; pfam08774 460265011271 MT-A70; Region: MT-A70; cl01947 460265011272 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 460265011273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265011274 Walker A motif; other site 460265011275 ATP binding site [chemical binding]; other site 460265011276 Part of AAA domain; Region: AAA_19; pfam13245 460265011277 Family description; Region: UvrD_C_2; pfam13538 460265011278 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265011279 Transcription termination factor nusG; Region: NusG; pfam02357 460265011280 Transposase domain (DUF772); Region: DUF772; pfam05598 460265011281 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265011282 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 460265011283 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 460265011284 DNA-binding site [nucleotide binding]; DNA binding site 460265011285 RNA-binding motif; other site 460265011286 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 460265011287 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 460265011288 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 460265011289 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 460265011290 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 460265011291 tandem repeat interface [polypeptide binding]; other site 460265011292 oligomer interface [polypeptide binding]; other site 460265011293 active site residues [active] 460265011294 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 460265011295 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 460265011296 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 460265011297 Phage-related minor tail protein [Function unknown]; Region: COG5281 460265011298 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 460265011299 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265011300 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265011301 catalytic residue [active] 460265011302 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 460265011303 Phage minor tail protein; Region: Phage_min_tail; cl01940 460265011304 Phage minor tail protein L; Region: Phage_tail_L; cl01908 460265011305 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 460265011306 MPN+ (JAMM) motif; other site 460265011307 Zinc-binding site [ion binding]; other site 460265011308 Phage-related protein, tail component [Function unknown]; Region: COG4723 460265011309 Phage-related protein, tail component [Function unknown]; Region: COG4733 460265011310 Putative phage tail protein; Region: Phage-tail_3; pfam13550 460265011311 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 460265011312 Interdomain contacts; other site 460265011313 Cytokine receptor motif; other site 460265011314 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 460265011315 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 460265011316 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 460265011317 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 460265011318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265011319 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265011320 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 460265011321 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265011322 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265011323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 460265011324 Winged helix-turn helix; Region: HTH_29; pfam13551 460265011325 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265011326 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 460265011327 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 460265011328 Domain of unknown function DUF21; Region: DUF21; pfam01595 460265011329 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 460265011330 Transporter associated domain; Region: CorC_HlyC; smart01091 460265011331 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 460265011332 CsbD-like; Region: CsbD; pfam05532 460265011333 Protein of unknown function (DUF327); Region: DUF327; cl00753 460265011334 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 460265011335 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 460265011336 ATP binding site [chemical binding]; other site 460265011337 Mg2+ binding site [ion binding]; other site 460265011338 G-X-G motif; other site 460265011339 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 460265011340 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 460265011341 cofactor binding site; other site 460265011342 DNA binding site [nucleotide binding] 460265011343 substrate interaction site [chemical binding]; other site 460265011344 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 460265011345 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 460265011346 additional DNA contacts [nucleotide binding]; other site 460265011347 mismatch recognition site; other site 460265011348 active site 460265011349 zinc binding site [ion binding]; other site 460265011350 DNA intercalation site [nucleotide binding]; other site 460265011351 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265011352 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265011353 ligand binding site [chemical binding]; other site 460265011354 flexible hinge region; other site 460265011355 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 460265011356 non-specific DNA interactions [nucleotide binding]; other site 460265011357 DNA binding site [nucleotide binding] 460265011358 sequence specific DNA binding site [nucleotide binding]; other site 460265011359 putative cAMP binding site [chemical binding]; other site 460265011360 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 460265011361 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 460265011362 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 460265011363 inhibitor site; inhibition site 460265011364 active site 460265011365 dimer interface [polypeptide binding]; other site 460265011366 catalytic residue [active] 460265011367 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 460265011368 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 460265011369 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 460265011370 catalytic residues [active] 460265011371 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 460265011372 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 460265011373 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 460265011374 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 460265011375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265011376 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265011377 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265011378 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 460265011379 Catalytic site [active] 460265011380 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 460265011381 FAD binding domain; Region: FAD_binding_4; pfam01565 460265011382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 460265011383 rod shape-determining protein MreC; Provisional; Region: PRK13922 460265011384 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 460265011385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265011386 DNA-binding site [nucleotide binding]; DNA binding site 460265011387 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 460265011388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265011389 homodimer interface [polypeptide binding]; other site 460265011390 catalytic residue [active] 460265011391 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 460265011392 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 460265011393 hydroxyglutarate oxidase; Provisional; Region: PRK11728 460265011394 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 460265011395 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 460265011396 tetramerization interface [polypeptide binding]; other site 460265011397 NAD(P) binding site [chemical binding]; other site 460265011398 catalytic residues [active] 460265011399 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 460265011400 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 460265011401 inhibitor site; inhibition site 460265011402 active site 460265011403 dimer interface [polypeptide binding]; other site 460265011404 catalytic residue [active] 460265011405 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265011406 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265011407 Walker A/P-loop; other site 460265011408 ATP binding site [chemical binding]; other site 460265011409 Q-loop/lid; other site 460265011410 ABC transporter signature motif; other site 460265011411 Walker B; other site 460265011412 D-loop; other site 460265011413 H-loop/switch region; other site 460265011414 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265011415 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265011416 Walker A/P-loop; other site 460265011417 ATP binding site [chemical binding]; other site 460265011418 Q-loop/lid; other site 460265011419 ABC transporter signature motif; other site 460265011420 Walker B; other site 460265011421 D-loop; other site 460265011422 H-loop/switch region; other site 460265011423 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265011424 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265011425 TM-ABC transporter signature motif; other site 460265011426 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 460265011427 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265011428 TM-ABC transporter signature motif; other site 460265011429 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 460265011430 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 460265011431 ligand binding site [chemical binding]; other site 460265011432 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 460265011433 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 460265011434 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 460265011435 active site 460265011436 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 460265011437 Proline racemase; Region: Pro_racemase; pfam05544 460265011438 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 460265011439 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265011440 DNA-binding site [nucleotide binding]; DNA binding site 460265011441 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 460265011442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265011443 homodimer interface [polypeptide binding]; other site 460265011444 catalytic residue [active] 460265011445 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 460265011446 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265011447 substrate binding pocket [chemical binding]; other site 460265011448 membrane-bound complex binding site; other site 460265011449 hinge residues; other site 460265011450 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 460265011451 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 460265011452 hydroxyglutarate oxidase; Provisional; Region: PRK11728 460265011453 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 460265011454 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 460265011455 tetramerization interface [polypeptide binding]; other site 460265011456 NAD(P) binding site [chemical binding]; other site 460265011457 catalytic residues [active] 460265011458 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 460265011459 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 460265011460 inhibitor site; inhibition site 460265011461 active site 460265011462 dimer interface [polypeptide binding]; other site 460265011463 catalytic residue [active] 460265011464 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 460265011465 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 460265011466 Walker A/P-loop; other site 460265011467 ATP binding site [chemical binding]; other site 460265011468 Q-loop/lid; other site 460265011469 ABC transporter signature motif; other site 460265011470 Walker B; other site 460265011471 D-loop; other site 460265011472 H-loop/switch region; other site 460265011473 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 460265011474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265011475 dimer interface [polypeptide binding]; other site 460265011476 conserved gate region; other site 460265011477 putative PBP binding loops; other site 460265011478 ABC-ATPase subunit interface; other site 460265011479 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 460265011480 Proline racemase; Region: Pro_racemase; pfam05544 460265011481 enoyl-CoA hydratase; Provisional; Region: PRK05862 460265011482 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265011483 substrate binding site [chemical binding]; other site 460265011484 oxyanion hole (OAH) forming residues; other site 460265011485 trimer interface [polypeptide binding]; other site 460265011486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265011487 NAD(P) binding site [chemical binding]; other site 460265011488 active site 460265011489 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 460265011490 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 460265011491 dimer interface [polypeptide binding]; other site 460265011492 active site 460265011493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265011494 putative substrate translocation pore; other site 460265011495 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 460265011496 putative FMN binding site [chemical binding]; other site 460265011497 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 460265011498 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265011499 acyl-activating enzyme (AAE) consensus motif; other site 460265011500 AMP binding site [chemical binding]; other site 460265011501 active site 460265011502 CoA binding site [chemical binding]; other site 460265011503 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265011504 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265011505 NifQ; Region: NifQ; pfam04891 460265011506 Rop-like; Region: Rop-like; pfam05082 460265011507 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 460265011508 4Fe-4S binding domain; Region: Fer4; cl02805 460265011509 probable nitrogen fixation protein; Region: TIGR02935 460265011510 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 460265011511 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 460265011512 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 460265011513 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 460265011514 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 460265011515 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 460265011516 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 460265011517 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 460265011518 MoFe protein beta/alpha subunit interactions; other site 460265011519 Beta subunit P cluster binding residues; other site 460265011520 MoFe protein beta subunit/Fe protein contacts; other site 460265011521 MoFe protein dimer/ dimer interactions; other site 460265011522 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 460265011523 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 460265011524 MoFe protein alpha/beta subunit interactions; other site 460265011525 Alpha subunit P cluster binding residues; other site 460265011526 FeMoco binding residues [chemical binding]; other site 460265011527 MoFe protein alpha subunit/Fe protein contacts; other site 460265011528 MoFe protein dimer/ dimer interactions; other site 460265011529 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 460265011530 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 460265011531 Nucleotide-binding sites [chemical binding]; other site 460265011532 Walker A motif; other site 460265011533 Switch I region of nucleotide binding site; other site 460265011534 Fe4S4 binding sites [ion binding]; other site 460265011535 Switch II region of nucleotide binding site; other site 460265011536 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 460265011537 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 460265011538 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 460265011539 inhibitor site; inhibition site 460265011540 active site 460265011541 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 460265011542 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 460265011543 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 460265011544 dimer interface [polypeptide binding]; other site 460265011545 decamer (pentamer of dimers) interface [polypeptide binding]; other site 460265011546 catalytic triad [active] 460265011547 peroxidatic and resolving cysteines [active] 460265011548 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 460265011549 Nif-specific regulatory protein; Region: nifA; TIGR01817 460265011550 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 460265011551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265011552 Walker A motif; other site 460265011553 ATP binding site [chemical binding]; other site 460265011554 Walker B motif; other site 460265011555 arginine finger; other site 460265011556 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 460265011557 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 460265011558 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265011559 FeS/SAM binding site; other site 460265011560 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 460265011561 hypothetical protein; Provisional; Region: PRK13795 460265011562 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 460265011563 NifZ domain; Region: NifZ; pfam04319 460265011564 NifT/FixU protein; Region: NifT; pfam06988 460265011565 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 460265011566 oxidoreductase; Provisional; Region: PRK10015 460265011567 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 460265011568 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 460265011569 Electron transfer flavoprotein domain; Region: ETF; pfam01012 460265011570 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 460265011571 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 460265011572 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 460265011573 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 460265011574 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 460265011575 Ligand binding site [chemical binding]; other site 460265011576 Electron transfer flavoprotein domain; Region: ETF; pfam01012 460265011577 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810 460265011578 serine O-acetyltransferase; Region: cysE; TIGR01172 460265011579 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 460265011580 trimer interface [polypeptide binding]; other site 460265011581 active site 460265011582 substrate binding site [chemical binding]; other site 460265011583 CoA binding site [chemical binding]; other site 460265011584 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 460265011585 Transposase; Region: HTH_Tnp_1; cl17663 460265011586 Integrase core domain; Region: rve; pfam00665 460265011587 Integrase core domain; Region: rve_3; cl15866 460265011588 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 460265011589 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265011590 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265011591 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 460265011592 putative substrate binding pocket [chemical binding]; other site 460265011593 putative dimerization interface [polypeptide binding]; other site 460265011594 Nodulation protein A (NodA); Region: NodA; pfam02474 460265011595 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 460265011596 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 460265011597 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 460265011598 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 460265011599 DXD motif; other site 460265011600 ATP-binding ABC transporter family nodulation protein NodI; Region: nodI; TIGR01288 460265011601 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 460265011602 Walker A/P-loop; other site 460265011603 ATP binding site [chemical binding]; other site 460265011604 Q-loop/lid; other site 460265011605 ABC transporter signature motif; other site 460265011606 Walker B; other site 460265011607 D-loop; other site 460265011608 H-loop/switch region; other site 460265011609 ABC-2 type transporter; Region: ABC2_membrane; cl17235 460265011610 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 460265011611 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 460265011612 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 460265011613 ligand-binding site [chemical binding]; other site 460265011614 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 460265011615 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265011616 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265011617 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 460265011618 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265011619 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265011620 ligand binding site [chemical binding]; other site 460265011621 flexible hinge region; other site 460265011622 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 460265011623 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 460265011624 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 460265011625 inhibitor site; inhibition site 460265011626 active site 460265011627 dimer interface [polypeptide binding]; other site 460265011628 catalytic residue [active] 460265011629 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 460265011630 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 460265011631 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 460265011632 DNA binding site [nucleotide binding] 460265011633 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 460265011634 putative ligand binding site [chemical binding]; other site 460265011635 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 460265011636 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265011637 DNA-binding site [nucleotide binding]; DNA binding site 460265011638 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 460265011639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265011640 homodimer interface [polypeptide binding]; other site 460265011641 catalytic residue [active] 460265011642 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 460265011643 Phage-related protein, tail component [Function unknown]; Region: COG4733 460265011644 Putative phage tail protein; Region: Phage-tail_3; pfam13550 460265011645 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 460265011646 Interdomain contacts; other site 460265011647 Cytokine receptor motif; other site 460265011648 Phage-related protein, tail component [Function unknown]; Region: COG4723 460265011649 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 460265011650 Phage minor tail protein L; Region: Phage_tail_L; cl01908 460265011651 Phage minor tail protein; Region: Phage_min_tail; cl01940 460265011652 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 460265011653 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 460265011654 Phage-related minor tail protein [Function unknown]; Region: COG5281 460265011655 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265011656 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265011657 catalytic residue [active] 460265011658 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 460265011659 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 460265011660 Phage-related protein [Function unknown]; Region: COG4695 460265011661 Phage portal protein; Region: Phage_portal; pfam04860 460265011662 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 460265011663 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 460265011664 Phage capsid family; Region: Phage_capsid; pfam05065 460265011665 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 460265011666 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 460265011667 active site 460265011668 Transcription termination factor nusG; Region: NusG; pfam02357 460265011669 transcriptional activator RfaH; Region: RfaH; TIGR01955 460265011670 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 460265011671 heterodimer interface [polypeptide binding]; other site 460265011672 homodimer interface [polypeptide binding]; other site 460265011673 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265011674 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 460265011675 polymerase nucleotide-binding site; other site 460265011676 DNA-binding residues [nucleotide binding]; DNA binding site 460265011677 nucleotide binding site [chemical binding]; other site 460265011678 primase nucleotide-binding site [nucleotide binding]; other site 460265011679 Domain of unknown function (DUF927); Region: DUF927; cl12098 460265011680 AAA domain; Region: AAA_30; pfam13604 460265011681 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 460265011682 Family description; Region: UvrD_C_2; pfam13538 460265011683 Methyltransferase domain; Region: Methyltransf_26; pfam13659 460265011684 VRR-NUC domain; Region: VRR_NUC; pfam08774 460265011685 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 460265011686 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 460265011687 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 460265011688 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 460265011689 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 460265011690 active site 460265011691 DNA binding site [nucleotide binding] 460265011692 Int/Topo IB signature motif; other site 460265011693 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 460265011694 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 460265011695 NADH dehydrogenase subunit B; Validated; Region: PRK06411 460265011696 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 460265011697 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 460265011698 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 460265011699 NADH dehydrogenase subunit D; Validated; Region: PRK06075 460265011700 NADH dehydrogenase subunit E; Validated; Region: PRK07539 460265011701 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 460265011702 putative dimer interface [polypeptide binding]; other site 460265011703 [2Fe-2S] cluster binding site [ion binding]; other site 460265011704 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 460265011705 SLBB domain; Region: SLBB; pfam10531 460265011706 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 460265011707 NADH dehydrogenase subunit G; Validated; Region: PRK09130 460265011708 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265011709 catalytic loop [active] 460265011710 iron binding site [ion binding]; other site 460265011711 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 460265011712 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 460265011713 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 460265011714 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 460265011715 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 460265011716 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 460265011717 4Fe-4S binding domain; Region: Fer4; pfam00037 460265011718 4Fe-4S binding domain; Region: Fer4; pfam00037 460265011719 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 460265011720 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 460265011721 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 460265011722 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 460265011723 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 460265011724 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 460265011725 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 460265011726 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 460265011727 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 460265011728 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 460265011729 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 460265011730 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 460265011731 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 460265011732 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 460265011733 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 460265011734 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 460265011735 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 460265011736 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265011737 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 460265011738 dimer interface [polypeptide binding]; other site 460265011739 substrate binding site [chemical binding]; other site 460265011740 metal binding site [ion binding]; metal-binding site 460265011741 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 460265011742 prolyl-tRNA synthetase; Provisional; Region: PRK12325 460265011743 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 460265011744 dimer interface [polypeptide binding]; other site 460265011745 motif 1; other site 460265011746 active site 460265011747 motif 2; other site 460265011748 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 460265011749 active site 460265011750 motif 3; other site 460265011751 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 460265011752 anticodon binding site; other site 460265011753 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 460265011754 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 460265011755 FtsX-like permease family; Region: FtsX; pfam02687 460265011756 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 460265011757 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 460265011758 Walker A/P-loop; other site 460265011759 ATP binding site [chemical binding]; other site 460265011760 Q-loop/lid; other site 460265011761 ABC transporter signature motif; other site 460265011762 Walker B; other site 460265011763 D-loop; other site 460265011764 H-loop/switch region; other site 460265011765 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 460265011766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265011767 dimer interface [polypeptide binding]; other site 460265011768 conserved gate region; other site 460265011769 ABC-ATPase subunit interface; other site 460265011770 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 460265011771 hypothetical protein; Provisional; Region: PRK08912 460265011772 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 460265011773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265011774 homodimer interface [polypeptide binding]; other site 460265011775 catalytic residue [active] 460265011776 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 460265011777 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265011778 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265011779 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 460265011780 Protein export membrane protein; Region: SecD_SecF; cl14618 460265011781 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 460265011782 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 460265011783 Restriction endonuclease; Region: Mrr_cat; pfam04471 460265011784 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 460265011785 metal ion-dependent adhesion site (MIDAS); other site 460265011786 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265011787 cyclase homology domain; Region: CHD; cd07302 460265011788 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 460265011789 nucleotidyl binding site; other site 460265011790 metal binding site [ion binding]; metal-binding site 460265011791 dimer interface [polypeptide binding]; other site 460265011792 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 460265011793 EF-hand domain pair; Region: EF_hand_5; pfam13499 460265011794 Ca2+ binding site [ion binding]; other site 460265011795 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 460265011796 Domain of unknown function DUF21; Region: DUF21; pfam01595 460265011797 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 460265011798 Transporter associated domain; Region: CorC_HlyC; smart01091 460265011799 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 460265011800 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 460265011801 metal binding site [ion binding]; metal-binding site 460265011802 active site 460265011803 I-site; other site 460265011804 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 460265011805 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 460265011806 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 460265011807 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 460265011808 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 460265011809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265011810 binding surface 460265011811 TPR motif; other site 460265011812 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 460265011813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265011814 putative substrate translocation pore; other site 460265011815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265011816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265011817 ATP binding site [chemical binding]; other site 460265011818 Mg2+ binding site [ion binding]; other site 460265011819 G-X-G motif; other site 460265011820 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 460265011821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265011822 active site 460265011823 phosphorylation site [posttranslational modification] 460265011824 intermolecular recognition site; other site 460265011825 dimerization interface [polypeptide binding]; other site 460265011826 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265011827 DNA binding site [nucleotide binding] 460265011828 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 460265011829 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 460265011830 active site 460265011831 substrate binding sites [chemical binding]; other site 460265011832 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 460265011833 active site 460265011834 substrate binding sites [chemical binding]; other site 460265011835 PAS domain S-box; Region: sensory_box; TIGR00229 460265011836 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265011837 putative active site [active] 460265011838 heme pocket [chemical binding]; other site 460265011839 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 460265011840 Histidine kinase; Region: HisKA_2; pfam07568 460265011841 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 460265011842 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 460265011843 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 460265011844 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 460265011845 dimerization interface [polypeptide binding]; other site 460265011846 putative DNA binding site [nucleotide binding]; other site 460265011847 putative Zn2+ binding site [ion binding]; other site 460265011848 DNA gyrase, A subunit; Region: gyrA; TIGR01063 460265011849 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 460265011850 CAP-like domain; other site 460265011851 active site 460265011852 primary dimer interface [polypeptide binding]; other site 460265011853 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 460265011854 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 460265011855 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 460265011856 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 460265011857 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 460265011858 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 460265011859 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 460265011860 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 460265011861 dimer interface [polypeptide binding]; other site 460265011862 ssDNA binding site [nucleotide binding]; other site 460265011863 tetramer (dimer of dimers) interface [polypeptide binding]; other site 460265011864 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 460265011865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 460265011866 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 460265011867 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 460265011868 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 460265011869 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 460265011870 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 460265011871 RNA binding site [nucleotide binding]; other site 460265011872 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 460265011873 EamA-like transporter family; Region: EamA; pfam00892 460265011874 Protein of unknown function (DUF466); Region: DUF466; pfam04328 460265011875 carbon starvation protein A; Provisional; Region: PRK15015 460265011876 Carbon starvation protein CstA; Region: CstA; pfam02554 460265011877 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 460265011878 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265011879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265011880 active site 460265011881 phosphorylation site [posttranslational modification] 460265011882 intermolecular recognition site; other site 460265011883 dimerization interface [polypeptide binding]; other site 460265011884 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265011885 DNA binding residues [nucleotide binding] 460265011886 dimerization interface [polypeptide binding]; other site 460265011887 Uncharacterized conserved protein [Function unknown]; Region: COG3287 460265011888 FIST N domain; Region: FIST; pfam08495 460265011889 FIST C domain; Region: FIST_C; pfam10442 460265011890 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265011891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265011892 dimer interface [polypeptide binding]; other site 460265011893 phosphorylation site [posttranslational modification] 460265011894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265011895 ATP binding site [chemical binding]; other site 460265011896 Mg2+ binding site [ion binding]; other site 460265011897 G-X-G motif; other site 460265011898 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 460265011899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265011900 active site 460265011901 phosphorylation site [posttranslational modification] 460265011902 intermolecular recognition site; other site 460265011903 dimerization interface [polypeptide binding]; other site 460265011904 GcrA cell cycle regulator; Region: GcrA; cl11564 460265011905 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 460265011906 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 460265011907 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 460265011908 Walker A/P-loop; other site 460265011909 ATP binding site [chemical binding]; other site 460265011910 Q-loop/lid; other site 460265011911 ABC transporter signature motif; other site 460265011912 Walker B; other site 460265011913 D-loop; other site 460265011914 H-loop/switch region; other site 460265011915 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 460265011916 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 460265011917 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 460265011918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265011919 dimer interface [polypeptide binding]; other site 460265011920 conserved gate region; other site 460265011921 ABC-ATPase subunit interface; other site 460265011922 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 460265011923 tellurium resistance terB-like protein; Region: terB_like; cd07177 460265011924 metal binding site [ion binding]; metal-binding site 460265011925 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 460265011926 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265011927 DNA-binding site [nucleotide binding]; DNA binding site 460265011928 UTRA domain; Region: UTRA; pfam07702 460265011929 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 460265011930 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 460265011931 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 460265011932 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 460265011933 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 460265011934 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265011935 Walker A/P-loop; other site 460265011936 ATP binding site [chemical binding]; other site 460265011937 Q-loop/lid; other site 460265011938 ABC transporter signature motif; other site 460265011939 Walker B; other site 460265011940 D-loop; other site 460265011941 H-loop/switch region; other site 460265011942 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 460265011943 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 460265011944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265011945 Walker A/P-loop; other site 460265011946 ATP binding site [chemical binding]; other site 460265011947 Q-loop/lid; other site 460265011948 ABC transporter signature motif; other site 460265011949 Walker B; other site 460265011950 D-loop; other site 460265011951 H-loop/switch region; other site 460265011952 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 460265011953 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 460265011954 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 460265011955 active site 460265011956 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 460265011957 Uncharacterized conserved protein [Function unknown]; Region: COG3025 460265011958 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 460265011959 putative active site [active] 460265011960 putative metal binding residues [ion binding]; other site 460265011961 signature motif; other site 460265011962 putative triphosphate binding site [ion binding]; other site 460265011963 CHAD domain; Region: CHAD; pfam05235 460265011964 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 460265011965 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 460265011966 Helix-turn-helix domain; Region: HTH_17; pfam12728 460265011967 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 460265011968 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 460265011969 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 460265011970 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 460265011971 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 460265011972 Walker A motif; other site 460265011973 ATP binding site [chemical binding]; other site 460265011974 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 460265011975 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 460265011976 VRR-NUC domain; Region: VRR_NUC; pfam08774 460265011977 Methyltransferase domain; Region: Methyltransf_26; pfam13659 460265011978 S-adenosylmethionine binding site [chemical binding]; other site 460265011979 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 460265011980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265011981 Walker A motif; other site 460265011982 ATP binding site [chemical binding]; other site 460265011983 Part of AAA domain; Region: AAA_19; pfam13245 460265011984 Family description; Region: UvrD_C_2; pfam13538 460265011985 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265011986 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 460265011987 hypothetical protein; Reviewed; Region: PRK09588 460265011988 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 460265011989 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 460265011990 putative ion selectivity filter; other site 460265011991 putative pore gating glutamate residue; other site 460265011992 putative H+/Cl- coupling transport residue; other site 460265011993 Uncharacterized conserved protein [Function unknown]; Region: COG5476 460265011994 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 460265011995 MlrC C-terminus; Region: MlrC_C; pfam07171 460265011996 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 460265011997 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 460265011998 hydroxyglutarate oxidase; Provisional; Region: PRK11728 460265011999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265012000 dimer interface [polypeptide binding]; other site 460265012001 conserved gate region; other site 460265012002 putative PBP binding loops; other site 460265012003 ABC-ATPase subunit interface; other site 460265012004 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 460265012005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265012006 ABC-ATPase subunit interface; other site 460265012007 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 460265012008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265012009 Walker A/P-loop; other site 460265012010 ATP binding site [chemical binding]; other site 460265012011 Q-loop/lid; other site 460265012012 ABC transporter signature motif; other site 460265012013 Walker B; other site 460265012014 D-loop; other site 460265012015 H-loop/switch region; other site 460265012016 TOBE domain; Region: TOBE_2; pfam08402 460265012017 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 460265012018 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 460265012019 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 460265012020 homotrimer interaction site [polypeptide binding]; other site 460265012021 putative active site [active] 460265012022 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265012023 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265012024 DNA-binding site [nucleotide binding]; DNA binding site 460265012025 FCD domain; Region: FCD; pfam07729 460265012026 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 460265012027 histidinol dehydrogenase; Region: hisD; TIGR00069 460265012028 NAD binding site [chemical binding]; other site 460265012029 dimerization interface [polypeptide binding]; other site 460265012030 product binding site; other site 460265012031 substrate binding site [chemical binding]; other site 460265012032 zinc binding site [ion binding]; other site 460265012033 catalytic residues [active] 460265012034 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 460265012035 homotrimer interaction site [polypeptide binding]; other site 460265012036 putative active site [active] 460265012037 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 460265012038 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265012039 Transposase [DNA replication, recombination, and repair]; Region: COG5433 460265012040 Transposase [DNA replication, recombination, and repair]; Region: COG5433 460265012041 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265012042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265012043 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 460265012044 putative dimerization interface [polypeptide binding]; other site 460265012045 Transcription antiterminator [Transcription]; Region: NusG; COG0250 460265012046 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 460265012047 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 460265012048 heterodimer interface [polypeptide binding]; other site 460265012049 homodimer interface [polypeptide binding]; other site 460265012050 Phage terminase, small subunit; Region: Terminase_4; pfam05119 460265012051 Phage Terminase; Region: Terminase_1; pfam03354 460265012052 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 460265012053 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 460265012054 Phage capsid family; Region: Phage_capsid; pfam05065 460265012055 Phage-related protein [Function unknown]; Region: COG4695 460265012056 Phage portal protein; Region: Phage_portal; pfam04860 460265012057 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 460265012058 oligomerization interface [polypeptide binding]; other site 460265012059 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 460265012060 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 460265012061 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 460265012062 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 460265012063 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 460265012064 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 460265012065 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 460265012066 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 460265012067 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 460265012068 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 460265012069 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 460265012070 NlpC/P60 family; Region: NLPC_P60; cl17555 460265012071 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 460265012072 Putative phage tail protein; Region: Phage-tail_3; pfam13550 460265012073 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 460265012074 Catalytic domain of bacteriophage endosialidase; Region: End_tail_spike; pfam12219 460265012075 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 460265012076 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 460265012077 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 460265012078 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 460265012079 short chain dehydrogenase; Provisional; Region: PRK06500 460265012080 classical (c) SDRs; Region: SDR_c; cd05233 460265012081 NAD(P) binding site [chemical binding]; other site 460265012082 active site 460265012083 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 460265012084 Homeodomain-like domain; Region: HTH_23; cl17451 460265012085 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 460265012086 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265012087 active site 460265012088 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 460265012089 active site 460265012090 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 460265012091 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 460265012092 active site 460265012093 homodimer interface [polypeptide binding]; other site 460265012094 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 460265012095 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 460265012096 NAD(P) binding site [chemical binding]; other site 460265012097 homodimer interface [polypeptide binding]; other site 460265012098 substrate binding site [chemical binding]; other site 460265012099 active site 460265012100 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 460265012101 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 460265012102 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 460265012103 NADP binding site [chemical binding]; other site 460265012104 active site 460265012105 putative substrate binding site [chemical binding]; other site 460265012106 Winged helix-turn helix; Region: HTH_29; pfam13551 460265012107 Winged helix-turn helix; Region: HTH_33; pfam13592 460265012108 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 460265012109 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265012110 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 460265012111 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265012112 active site 460265012113 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265012114 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 460265012115 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 460265012116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265012117 NAD(P) binding site [chemical binding]; other site 460265012118 active site 460265012119 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 460265012120 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 460265012121 NAD binding site [chemical binding]; other site 460265012122 substrate binding site [chemical binding]; other site 460265012123 active site 460265012124 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 460265012125 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265012126 active site 460265012127 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 460265012128 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 460265012129 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 460265012130 N-terminal domain interface [polypeptide binding]; other site 460265012131 dimer interface [polypeptide binding]; other site 460265012132 substrate binding pocket (H-site) [chemical binding]; other site 460265012133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265012134 H+ Antiporter protein; Region: 2A0121; TIGR00900 460265012135 putative substrate translocation pore; other site 460265012136 Homeodomain-like domain; Region: HTH_23; cl17451 460265012137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265012138 Protein of unknown function (DUF563); Region: DUF563; pfam04577 460265012139 Methyltransferase domain; Region: Methyltransf_24; pfam13578 460265012140 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 460265012141 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 460265012142 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 460265012143 NAD binding site [chemical binding]; other site 460265012144 substrate binding site [chemical binding]; other site 460265012145 homodimer interface [polypeptide binding]; other site 460265012146 active site 460265012147 Rhamnan synthesis protein F; Region: RgpF; pfam05045 460265012148 Transposase; Region: HTH_Tnp_1; cl17663 460265012149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 460265012150 Transposase; Region: HTH_Tnp_1; pfam01527 460265012151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 460265012152 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 460265012153 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 460265012154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 460265012155 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 460265012156 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 460265012157 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 460265012158 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 460265012159 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 460265012160 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265012161 active site 460265012162 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 460265012163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265012164 Helix-turn-helix domain; Region: HTH_36; pfam13730 460265012165 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 460265012166 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 460265012167 active site 460265012168 catalytic residues [active] 460265012169 DNA binding site [nucleotide binding] 460265012170 Int/Topo IB signature motif; other site 460265012171 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 460265012172 Chain length determinant protein; Region: Wzz; pfam02706 460265012173 AAA domain; Region: AAA_31; pfam13614 460265012174 Right handed beta helix region; Region: Beta_helix; pfam13229 460265012175 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265012176 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 460265012177 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 460265012178 putative active site [active] 460265012179 putative metal binding site [ion binding]; other site 460265012180 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 460265012181 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 460265012182 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 460265012183 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 460265012184 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 460265012185 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 460265012186 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265012187 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 460265012188 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 460265012189 dimer interface [polypeptide binding]; other site 460265012190 motif 1; other site 460265012191 active site 460265012192 motif 2; other site 460265012193 motif 3; other site 460265012194 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 460265012195 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 460265012196 oligomer interface [polypeptide binding]; other site 460265012197 tandem repeat interface [polypeptide binding]; other site 460265012198 active site residues [active] 460265012199 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 460265012200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 460265012201 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 460265012202 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 460265012203 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265012204 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265012205 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 460265012206 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265012207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265012208 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 460265012209 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 460265012210 substrate binding pocket [chemical binding]; other site 460265012211 chain length determination region; other site 460265012212 substrate-Mg2+ binding site; other site 460265012213 catalytic residues [active] 460265012214 aspartate-rich region 1; other site 460265012215 active site lid residues [active] 460265012216 aspartate-rich region 2; other site 460265012217 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 460265012218 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 460265012219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265012220 binding surface 460265012221 TPR motif; other site 460265012222 TPR repeat; Region: TPR_11; pfam13414 460265012223 TPR repeat; Region: TPR_11; pfam13414 460265012224 TPR repeat; Region: TPR_11; pfam13414 460265012225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265012226 binding surface 460265012227 TPR motif; other site 460265012228 TPR repeat; Region: TPR_11; pfam13414 460265012229 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 460265012230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265012231 NAD(P) binding site [chemical binding]; other site 460265012232 active site 460265012233 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 460265012234 TPP-binding site [chemical binding]; other site 460265012235 dimer interface [polypeptide binding]; other site 460265012236 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 460265012237 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 460265012238 PYR/PP interface [polypeptide binding]; other site 460265012239 dimer interface [polypeptide binding]; other site 460265012240 TPP binding site [chemical binding]; other site 460265012241 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 460265012242 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 460265012243 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 460265012244 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 460265012245 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 460265012246 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 460265012247 DctM-like transporters; Region: DctM; pfam06808 460265012248 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 460265012249 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 460265012250 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 460265012251 TPP-binding site [chemical binding]; other site 460265012252 dimer interface [polypeptide binding]; other site 460265012253 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 460265012254 PYR/PP interface [polypeptide binding]; other site 460265012255 dimer interface [polypeptide binding]; other site 460265012256 TPP binding site [chemical binding]; other site 460265012257 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 460265012258 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265012259 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 460265012260 substrate binding pocket [chemical binding]; other site 460265012261 membrane-bound complex binding site; other site 460265012262 hinge residues; other site 460265012263 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 460265012264 putative acyl-CoA synthetase; Provisional; Region: PRK06018 460265012265 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 460265012266 dimer interface [polypeptide binding]; other site 460265012267 acyl-activating enzyme (AAE) consensus motif; other site 460265012268 putative active site [active] 460265012269 AMP binding site [chemical binding]; other site 460265012270 putative CoA binding site [chemical binding]; other site 460265012271 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 460265012272 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 460265012273 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 460265012274 two-component response regulator; Provisional; Region: PRK09191 460265012275 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 460265012276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265012277 active site 460265012278 phosphorylation site [posttranslational modification] 460265012279 intermolecular recognition site; other site 460265012280 dimerization interface [polypeptide binding]; other site 460265012281 General stress protein [General function prediction only]; Region: GsiB; COG3729 460265012282 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 460265012283 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 460265012284 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 460265012285 Walker A/P-loop; other site 460265012286 ATP binding site [chemical binding]; other site 460265012287 Q-loop/lid; other site 460265012288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265012289 ABC transporter signature motif; other site 460265012290 Walker B; other site 460265012291 D-loop; other site 460265012292 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265012293 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265012294 ligand binding site [chemical binding]; other site 460265012295 flexible hinge region; other site 460265012296 short chain dehydrogenase; Provisional; Region: PRK06949 460265012297 classical (c) SDRs; Region: SDR_c; cd05233 460265012298 NAD(P) binding site [chemical binding]; other site 460265012299 active site 460265012300 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 460265012301 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 460265012302 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 460265012303 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 460265012304 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 460265012305 active site 460265012306 HIGH motif; other site 460265012307 dimer interface [polypeptide binding]; other site 460265012308 KMSKS motif; other site 460265012309 intracellular septation protein A; Reviewed; Region: PRK00259 460265012310 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 460265012311 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 460265012312 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 460265012313 P loop; other site 460265012314 GTP binding site [chemical binding]; other site 460265012315 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 460265012316 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 460265012317 active site 460265012318 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 460265012319 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 460265012320 active site 460265012321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265012322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265012323 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265012324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265012325 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 460265012326 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 460265012327 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 460265012328 acyl carrier protein; Provisional; Region: PRK07081 460265012329 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 460265012330 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 460265012331 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 460265012332 hypothetical protein; Validated; Region: PRK07080 460265012333 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 460265012334 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 460265012335 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 460265012336 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 460265012337 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 460265012338 ATP-grasp domain; Region: ATP-grasp_4; cl17255 460265012339 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 460265012340 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 460265012341 ATP-grasp domain; Region: ATP-grasp_4; cl17255 460265012342 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 460265012343 IMP binding site; other site 460265012344 dimer interface [polypeptide binding]; other site 460265012345 partial ornithine binding site; other site 460265012346 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 460265012347 classical (c) SDRs; Region: SDR_c; cd05233 460265012348 NAD(P) binding site [chemical binding]; other site 460265012349 active site 460265012350 Predicted membrane protein [Function unknown]; Region: COG2246 460265012351 GtrA-like protein; Region: GtrA; pfam04138 460265012352 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 460265012353 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 460265012354 Ligand Binding Site [chemical binding]; other site 460265012355 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265012356 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265012357 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265012358 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 460265012359 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 460265012360 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 460265012361 Glycoprotease family; Region: Peptidase_M22; pfam00814 460265012362 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 460265012363 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 460265012364 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 460265012365 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 460265012366 putative acyl-acceptor binding pocket; other site 460265012367 TolQ protein; Region: tolQ; TIGR02796 460265012368 TolR protein; Region: tolR; TIGR02801 460265012369 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 460265012370 translocation protein TolB; Provisional; Region: tolB; PRK05137 460265012371 TolB amino-terminal domain; Region: TolB_N; pfam04052 460265012372 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 460265012373 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 460265012374 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 460265012375 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 460265012376 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265012377 salt bridge; other site 460265012378 non-specific DNA binding site [nucleotide binding]; other site 460265012379 sequence-specific DNA binding site [nucleotide binding]; other site 460265012380 Protein of unknown function (DUF497); Region: DUF497; pfam04365 460265012381 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 460265012382 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265012383 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 460265012384 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265012385 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265012386 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 460265012387 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 460265012388 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 460265012389 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 460265012390 active site 460265012391 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 460265012392 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 460265012393 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 460265012394 putative active site pocket [active] 460265012395 dimerization interface [polypeptide binding]; other site 460265012396 putative catalytic residue [active] 460265012397 Major Facilitator Superfamily; Region: MFS_1; pfam07690 460265012398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265012399 putative substrate translocation pore; other site 460265012400 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265012401 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265012402 Walker A/P-loop; other site 460265012403 ATP binding site [chemical binding]; other site 460265012404 Q-loop/lid; other site 460265012405 ABC transporter signature motif; other site 460265012406 Walker B; other site 460265012407 D-loop; other site 460265012408 H-loop/switch region; other site 460265012409 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265012410 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265012411 Walker A/P-loop; other site 460265012412 ATP binding site [chemical binding]; other site 460265012413 Q-loop/lid; other site 460265012414 ABC transporter signature motif; other site 460265012415 Walker B; other site 460265012416 D-loop; other site 460265012417 H-loop/switch region; other site 460265012418 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265012419 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265012420 putative ligand binding site [chemical binding]; other site 460265012421 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265012422 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265012423 putative ligand binding site [chemical binding]; other site 460265012424 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265012425 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 460265012426 TM-ABC transporter signature motif; other site 460265012427 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265012428 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265012429 TM-ABC transporter signature motif; other site 460265012430 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 460265012431 putative dimer interface [polypeptide binding]; other site 460265012432 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265012433 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 460265012434 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 460265012435 inhibitor-cofactor binding pocket; inhibition site 460265012436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265012437 catalytic residue [active] 460265012438 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 460265012439 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 460265012440 Potassium binding sites [ion binding]; other site 460265012441 Cesium cation binding sites [ion binding]; other site 460265012442 Cupin domain; Region: Cupin_2; pfam07883 460265012443 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 460265012444 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 460265012445 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 460265012446 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 460265012447 UGMP family protein; Validated; Region: PRK09604 460265012448 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 460265012449 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 460265012450 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 460265012451 active site 460265012452 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 460265012453 HemY protein N-terminus; Region: HemY_N; pfam07219 460265012454 EthD domain; Region: EthD; cl17553 460265012455 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 460265012456 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 460265012457 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 460265012458 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 460265012459 active site 460265012460 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 460265012461 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 460265012462 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265012463 substrate binding pocket [chemical binding]; other site 460265012464 membrane-bound complex binding site; other site 460265012465 hinge residues; other site 460265012466 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 460265012467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265012468 dimer interface [polypeptide binding]; other site 460265012469 conserved gate region; other site 460265012470 putative PBP binding loops; other site 460265012471 ABC-ATPase subunit interface; other site 460265012472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265012473 dimer interface [polypeptide binding]; other site 460265012474 conserved gate region; other site 460265012475 putative PBP binding loops; other site 460265012476 ABC-ATPase subunit interface; other site 460265012477 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 460265012478 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 460265012479 Walker A/P-loop; other site 460265012480 ATP binding site [chemical binding]; other site 460265012481 Q-loop/lid; other site 460265012482 ABC transporter signature motif; other site 460265012483 Walker B; other site 460265012484 D-loop; other site 460265012485 H-loop/switch region; other site 460265012486 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 460265012487 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 460265012488 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 460265012489 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 460265012490 Putative zinc-finger; Region: zf-HC2; pfam13490 460265012491 RNA polymerase sigma factor; Provisional; Region: PRK12511 460265012492 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265012493 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 460265012494 DNA binding residues [nucleotide binding] 460265012495 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 460265012496 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 460265012497 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 460265012498 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 460265012499 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265012500 FeS/SAM binding site; other site 460265012501 Phosphotransferase enzyme family; Region: APH; pfam01636 460265012502 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 460265012503 putative active site [active] 460265012504 putative substrate binding site [chemical binding]; other site 460265012505 ATP binding site [chemical binding]; other site 460265012506 MarR family; Region: MarR_2; cl17246 460265012507 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 460265012508 Creatinine amidohydrolase; Region: Creatininase; pfam02633 460265012509 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 460265012510 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 460265012511 P-loop, Walker A motif; other site 460265012512 Base recognition motif; other site 460265012513 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 460265012514 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 460265012515 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 460265012516 cyclase homology domain; Region: CHD; cd07302 460265012517 nucleotidyl binding site; other site 460265012518 metal binding site [ion binding]; metal-binding site 460265012519 dimer interface [polypeptide binding]; other site 460265012520 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 460265012521 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265012522 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265012523 ligand binding site [chemical binding]; other site 460265012524 flexible hinge region; other site 460265012525 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 460265012526 putative switch regulator; other site 460265012527 non-specific DNA interactions [nucleotide binding]; other site 460265012528 DNA binding site [nucleotide binding] 460265012529 sequence specific DNA binding site [nucleotide binding]; other site 460265012530 putative cAMP binding site [chemical binding]; other site 460265012531 Gas vesicle protein K; Region: GvpK; pfam05121 460265012532 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 460265012533 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 460265012534 glutaminase; Provisional; Region: PRK00971 460265012535 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 460265012536 glutamine synthetase; Region: PLN02284 460265012537 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 460265012538 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 460265012539 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 460265012540 EamA-like transporter family; Region: EamA; pfam00892 460265012541 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 460265012542 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 460265012543 active site 460265012544 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 460265012545 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 460265012546 putative acyl-acceptor binding pocket; other site 460265012547 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265012548 acyl-activating enzyme (AAE) consensus motif; other site 460265012549 AMP binding site [chemical binding]; other site 460265012550 active site 460265012551 CoA binding site [chemical binding]; other site 460265012552 yiaA/B two helix domain; Region: YiaAB; cl01759 460265012553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265012554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265012555 WHG domain; Region: WHG; pfam13305 460265012556 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 460265012557 oligomerization interface [polypeptide binding]; other site 460265012558 active site 460265012559 metal binding site [ion binding]; metal-binding site 460265012560 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 460265012561 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 460265012562 Uncharacterized conserved protein [Function unknown]; Region: COG3287 460265012563 FIST N domain; Region: FIST; pfam08495 460265012564 FIST C domain; Region: FIST_C; pfam10442 460265012565 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 460265012566 putative FMN binding site [chemical binding]; other site 460265012567 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 460265012568 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 460265012569 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 460265012570 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 460265012571 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 460265012572 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 460265012573 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 460265012574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265012575 NAD(P) binding site [chemical binding]; other site 460265012576 active site 460265012577 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 460265012578 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 460265012579 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 460265012580 catalytic site [active] 460265012581 subunit interface [polypeptide binding]; other site 460265012582 Yqey-like protein; Region: YqeY; pfam09424 460265012583 Predicted membrane protein [Function unknown]; Region: COG4763 460265012584 Acyltransferase family; Region: Acyl_transf_3; pfam01757 460265012585 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 460265012586 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 460265012587 ThiC-associated domain; Region: ThiC-associated; pfam13667 460265012588 ThiC family; Region: ThiC; pfam01964 460265012589 FlaG protein; Region: FlaG; cl00591 460265012590 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 460265012591 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 460265012592 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 460265012593 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 460265012594 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 460265012595 quinone interaction residues [chemical binding]; other site 460265012596 active site 460265012597 catalytic residues [active] 460265012598 FMN binding site [chemical binding]; other site 460265012599 substrate binding site [chemical binding]; other site 460265012600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 460265012601 Predicted transcriptional regulator [Transcription]; Region: COG2932 460265012602 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 460265012603 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 460265012604 Catalytic site [active] 460265012605 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 460265012606 Na binding site [ion binding]; other site 460265012607 PAS fold; Region: PAS_7; pfam12860 460265012608 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265012609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265012610 dimer interface [polypeptide binding]; other site 460265012611 phosphorylation site [posttranslational modification] 460265012612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265012613 ATP binding site [chemical binding]; other site 460265012614 Mg2+ binding site [ion binding]; other site 460265012615 G-X-G motif; other site 460265012616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265012617 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 460265012618 active site 460265012619 phosphorylation site [posttranslational modification] 460265012620 intermolecular recognition site; other site 460265012621 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 460265012622 hypothetical protein; Validated; Region: PRK09039 460265012623 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 460265012624 ligand binding site [chemical binding]; other site 460265012625 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 460265012626 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 460265012627 putative active site [active] 460265012628 metal binding site [ion binding]; metal-binding site 460265012629 homodimer binding site [polypeptide binding]; other site 460265012630 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 460265012631 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 460265012632 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 460265012633 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 460265012634 active site 460265012635 intersubunit interface [polypeptide binding]; other site 460265012636 catalytic residue [active] 460265012637 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 460265012638 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 460265012639 substrate binding site [chemical binding]; other site 460265012640 ATP binding site [chemical binding]; other site 460265012641 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 460265012642 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 460265012643 active site 460265012644 substrate binding site [chemical binding]; other site 460265012645 metal binding site [ion binding]; metal-binding site 460265012646 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 460265012647 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 460265012648 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 460265012649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265012650 short chain dehydrogenase; Validated; Region: PRK07069 460265012651 NAD(P) binding site [chemical binding]; other site 460265012652 active site 460265012653 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 460265012654 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 460265012655 active site 460265012656 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 460265012657 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 460265012658 Mechanosensitive ion channel; Region: MS_channel; pfam00924 460265012659 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 460265012660 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 460265012661 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 460265012662 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 460265012663 ligand binding site [chemical binding]; other site 460265012664 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 460265012665 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 460265012666 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 460265012667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265012668 Walker A/P-loop; other site 460265012669 ATP binding site [chemical binding]; other site 460265012670 Q-loop/lid; other site 460265012671 ABC transporter signature motif; other site 460265012672 Walker B; other site 460265012673 D-loop; other site 460265012674 H-loop/switch region; other site 460265012675 cyanophycin synthetase; Provisional; Region: PRK14016 460265012676 UTRA domain; Region: UTRA; cl17743 460265012677 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 460265012678 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 460265012679 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 460265012680 Cytochrome c; Region: Cytochrom_C; cl11414 460265012681 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 460265012682 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265012683 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 460265012684 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265012685 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 460265012686 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265012687 catalytic loop [active] 460265012688 iron binding site [ion binding]; other site 460265012689 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 460265012690 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 460265012691 putative active site [active] 460265012692 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 460265012693 Peptidase family M23; Region: Peptidase_M23; pfam01551 460265012694 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 460265012695 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 460265012696 active site 460265012697 substrate binding site [chemical binding]; other site 460265012698 coenzyme B12 binding site [chemical binding]; other site 460265012699 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 460265012700 B12 binding site [chemical binding]; other site 460265012701 cobalt ligand [ion binding]; other site 460265012702 PAS fold; Region: PAS_7; pfam12860 460265012703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265012704 dimer interface [polypeptide binding]; other site 460265012705 phosphorylation site [posttranslational modification] 460265012706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265012707 ATP binding site [chemical binding]; other site 460265012708 Mg2+ binding site [ion binding]; other site 460265012709 G-X-G motif; other site 460265012710 Response regulator receiver domain; Region: Response_reg; pfam00072 460265012711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265012712 active site 460265012713 phosphorylation site [posttranslational modification] 460265012714 intermolecular recognition site; other site 460265012715 dimerization interface [polypeptide binding]; other site 460265012716 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 460265012717 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 460265012718 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 460265012719 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 460265012720 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 460265012721 Methyltransferase domain; Region: Methyltransf_23; pfam13489 460265012722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265012723 S-adenosylmethionine binding site [chemical binding]; other site 460265012724 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 460265012725 FAD binding domain; Region: FAD_binding_4; pfam01565 460265012726 Cytochrome c2 [Energy production and conversion]; Region: COG3474 460265012727 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 460265012728 PAS fold; Region: PAS_4; pfam08448 460265012729 PAS fold; Region: PAS_3; pfam08447 460265012730 PAS fold; Region: PAS_7; pfam12860 460265012731 PAS domain S-box; Region: sensory_box; TIGR00229 460265012732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265012733 putative active site [active] 460265012734 heme pocket [chemical binding]; other site 460265012735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265012736 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265012737 dimer interface [polypeptide binding]; other site 460265012738 phosphorylation site [posttranslational modification] 460265012739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265012740 ATP binding site [chemical binding]; other site 460265012741 Mg2+ binding site [ion binding]; other site 460265012742 G-X-G motif; other site 460265012743 Response regulator receiver domain; Region: Response_reg; pfam00072 460265012744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265012745 active site 460265012746 phosphorylation site [posttranslational modification] 460265012747 intermolecular recognition site; other site 460265012748 dimerization interface [polypeptide binding]; other site 460265012749 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 460265012750 putative binding surface; other site 460265012751 active site 460265012752 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 460265012753 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 460265012754 putative metal binding site; other site 460265012755 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 460265012756 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 460265012757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265012758 Walker A/P-loop; other site 460265012759 ATP binding site [chemical binding]; other site 460265012760 Q-loop/lid; other site 460265012761 ABC transporter signature motif; other site 460265012762 Walker B; other site 460265012763 D-loop; other site 460265012764 H-loop/switch region; other site 460265012765 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 460265012766 Amidase; Region: Amidase; cl11426 460265012767 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 460265012768 putative substrate binding pocket [chemical binding]; other site 460265012769 AC domain interface; other site 460265012770 catalytic triad [active] 460265012771 AB domain interface; other site 460265012772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265012773 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 460265012774 NAD(P) binding site [chemical binding]; other site 460265012775 active site 460265012776 acetoacetate decarboxylase; Provisional; Region: PRK02265 460265012777 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 460265012778 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 460265012779 active site 460265012780 nucleophile elbow; other site 460265012781 Patatin phospholipase; Region: DUF3734; pfam12536 460265012782 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 460265012783 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 460265012784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 460265012785 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265012786 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265012787 ligand binding site [chemical binding]; other site 460265012788 flexible hinge region; other site 460265012789 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 460265012790 CHASE2 domain; Region: CHASE2; pfam05226 460265012791 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 460265012792 cyclase homology domain; Region: CHD; cd07302 460265012793 nucleotidyl binding site; other site 460265012794 metal binding site [ion binding]; metal-binding site 460265012795 dimer interface [polypeptide binding]; other site 460265012796 FecR protein; Region: FecR; pfam04773 460265012797 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 460265012798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 460265012799 Transposase; Region: DDE_Tnp_ISL3; pfam01610 460265012800 Transposase; Region: DDE_Tnp_ISL3; pfam01610 460265012801 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 460265012802 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 460265012803 active site 460265012804 HIGH motif; other site 460265012805 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 460265012806 active site 460265012807 KMSKS motif; other site 460265012808 trehalose synthase; Region: treS_nterm; TIGR02456 460265012809 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 460265012810 active site 460265012811 catalytic site [active] 460265012812 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265012813 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 460265012814 putative ligand binding site [chemical binding]; other site 460265012815 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 460265012816 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265012817 TM-ABC transporter signature motif; other site 460265012818 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265012819 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265012820 TM-ABC transporter signature motif; other site 460265012821 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 460265012822 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265012823 Walker A/P-loop; other site 460265012824 ATP binding site [chemical binding]; other site 460265012825 Q-loop/lid; other site 460265012826 ABC transporter signature motif; other site 460265012827 Walker B; other site 460265012828 D-loop; other site 460265012829 H-loop/switch region; other site 460265012830 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 460265012831 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265012832 Walker A/P-loop; other site 460265012833 ATP binding site [chemical binding]; other site 460265012834 Q-loop/lid; other site 460265012835 ABC transporter signature motif; other site 460265012836 Walker B; other site 460265012837 D-loop; other site 460265012838 H-loop/switch region; other site 460265012839 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 460265012840 Beta-lactamase; Region: Beta-lactamase; pfam00144 460265012841 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 460265012842 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265012843 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265012844 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 460265012845 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265012846 substrate binding pocket [chemical binding]; other site 460265012847 membrane-bound complex binding site; other site 460265012848 hinge residues; other site 460265012849 hypothetical protein; Provisional; Region: PRK07483 460265012850 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 460265012851 inhibitor-cofactor binding pocket; inhibition site 460265012852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265012853 catalytic residue [active] 460265012854 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 460265012855 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 460265012856 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 460265012857 putative active site [active] 460265012858 Sm and related proteins; Region: Sm_like; cl00259 460265012859 ribosome maturation protein RimP; Reviewed; Region: PRK00092 460265012860 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 460265012861 putative oligomer interface [polypeptide binding]; other site 460265012862 putative RNA binding site [nucleotide binding]; other site 460265012863 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 460265012864 NusA N-terminal domain; Region: NusA_N; pfam08529 460265012865 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 460265012866 RNA binding site [nucleotide binding]; other site 460265012867 homodimer interface [polypeptide binding]; other site 460265012868 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 460265012869 G-X-X-G motif; other site 460265012870 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 460265012871 G-X-X-G motif; other site 460265012872 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 460265012873 hypothetical protein; Provisional; Region: PRK09190 460265012874 Protein of unknown function (DUF448); Region: DUF448; pfam04296 460265012875 putative RNA binding cleft [nucleotide binding]; other site 460265012876 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 460265012877 translation initiation factor IF-2; Region: IF-2; TIGR00487 460265012878 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 460265012879 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 460265012880 G1 box; other site 460265012881 putative GEF interaction site [polypeptide binding]; other site 460265012882 GTP/Mg2+ binding site [chemical binding]; other site 460265012883 Switch I region; other site 460265012884 G2 box; other site 460265012885 G3 box; other site 460265012886 Switch II region; other site 460265012887 G4 box; other site 460265012888 G5 box; other site 460265012889 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 460265012890 Translation-initiation factor 2; Region: IF-2; pfam11987 460265012891 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 460265012892 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 460265012893 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 460265012894 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 460265012895 RNA binding site [nucleotide binding]; other site 460265012896 active site 460265012897 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 460265012898 active site 460265012899 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 460265012900 NnrU protein; Region: NnrU; pfam07298 460265012901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 460265012902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 460265012903 GTP-binding protein Der; Reviewed; Region: PRK00093 460265012904 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 460265012905 G1 box; other site 460265012906 GTP/Mg2+ binding site [chemical binding]; other site 460265012907 Switch I region; other site 460265012908 G2 box; other site 460265012909 Switch II region; other site 460265012910 G3 box; other site 460265012911 G4 box; other site 460265012912 G5 box; other site 460265012913 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 460265012914 G1 box; other site 460265012915 GTP/Mg2+ binding site [chemical binding]; other site 460265012916 Switch I region; other site 460265012917 G2 box; other site 460265012918 G3 box; other site 460265012919 Switch II region; other site 460265012920 G4 box; other site 460265012921 G5 box; other site 460265012922 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 460265012923 folate binding site [chemical binding]; other site 460265012924 NADP+ binding site [chemical binding]; other site 460265012925 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 460265012926 classical (c) SDRs; Region: SDR_c; cd05233 460265012927 NAD(P) binding site [chemical binding]; other site 460265012928 active site 460265012929 amidophosphoribosyltransferase; Provisional; Region: PRK09123 460265012930 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 460265012931 active site 460265012932 tetramer interface [polypeptide binding]; other site 460265012933 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 460265012934 active site 460265012935 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 460265012936 Colicin V production protein; Region: Colicin_V; pfam02674 460265012937 DNA repair protein RadA; Provisional; Region: PRK11823 460265012938 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 460265012939 Walker A motif/ATP binding site; other site 460265012940 ATP binding site [chemical binding]; other site 460265012941 Walker B motif; other site 460265012942 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 460265012943 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 460265012944 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 460265012945 active site 460265012946 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 460265012947 dimer interface [polypeptide binding]; other site 460265012948 substrate binding site [chemical binding]; other site 460265012949 catalytic residues [active] 460265012950 replicative DNA helicase; Provisional; Region: PRK09165 460265012951 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 460265012952 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 460265012953 Walker A motif; other site 460265012954 ATP binding site [chemical binding]; other site 460265012955 Walker B motif; other site 460265012956 DNA binding loops [nucleotide binding] 460265012957 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 460265012958 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 460265012959 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 460265012960 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 460265012961 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 460265012962 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 460265012963 CoA binding domain; Region: CoA_binding_2; pfam13380 460265012964 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 460265012965 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 460265012966 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 460265012967 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 460265012968 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265012969 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265012970 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 460265012971 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 460265012972 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 460265012973 putative active site [active] 460265012974 putative catalytic site [active] 460265012975 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 460265012976 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 460265012977 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 460265012978 amphipathic channel; other site 460265012979 Asn-Pro-Ala signature motifs; other site 460265012980 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 460265012981 ligand binding site [chemical binding]; other site 460265012982 active site 460265012983 UGI interface [polypeptide binding]; other site 460265012984 catalytic site [active] 460265012985 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 460265012986 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 460265012987 active site 460265012988 metal binding site [ion binding]; metal-binding site 460265012989 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 460265012990 ferrochelatase; Reviewed; Region: hemH; PRK00035 460265012991 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 460265012992 C-terminal domain interface [polypeptide binding]; other site 460265012993 active site 460265012994 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 460265012995 active site 460265012996 N-terminal domain interface [polypeptide binding]; other site 460265012997 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 460265012998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 460265012999 putative aldolase; Validated; Region: PRK08130 460265013000 intersubunit interface [polypeptide binding]; other site 460265013001 active site 460265013002 Zn2+ binding site [ion binding]; other site 460265013003 Transcriptional regulators [Transcription]; Region: PurR; COG1609 460265013004 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 460265013005 DNA binding site [nucleotide binding] 460265013006 domain linker motif; other site 460265013007 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 460265013008 putative dimerization interface [polypeptide binding]; other site 460265013009 putative ligand binding site [chemical binding]; other site 460265013010 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 460265013011 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 460265013012 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 460265013013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 460265013014 guanine deaminase; Provisional; Region: PRK09228 460265013015 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 460265013016 active site 460265013017 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 460265013018 Predicted integral membrane protein [Function unknown]; Region: COG5617 460265013019 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265013020 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 460265013021 catalytic loop [active] 460265013022 iron binding site [ion binding]; other site 460265013023 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 460265013024 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 460265013025 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 460265013026 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265013027 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 460265013028 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265013029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 460265013030 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 460265013031 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265013032 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 460265013033 active site 460265013034 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 460265013035 putative NAD(P) binding site [chemical binding]; other site 460265013036 glucosyltransferase MdoH; Provisional; Region: PRK05454 460265013037 active site 460265013038 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265013039 glutathione reductase; Validated; Region: PRK06116 460265013040 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 460265013041 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 460265013042 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 460265013043 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 460265013044 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 460265013045 tetramer (dimer of dimers) interface [polypeptide binding]; other site 460265013046 active site 460265013047 dimer interface [polypeptide binding]; other site 460265013048 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 460265013049 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 460265013050 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 460265013051 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 460265013052 active site 460265013053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 460265013054 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 460265013055 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 460265013056 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 460265013057 dimerization interface [polypeptide binding]; other site 460265013058 DPS ferroxidase diiron center [ion binding]; other site 460265013059 ion pore; other site 460265013060 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 460265013061 YcaO-like family; Region: YcaO; pfam02624 460265013062 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 460265013063 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 460265013064 putative FMN binding site [chemical binding]; other site 460265013065 NADPH bind site [chemical binding]; other site 460265013066 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 460265013067 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 460265013068 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 460265013069 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265013070 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 460265013071 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265013072 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 460265013073 succinic semialdehyde dehydrogenase; Region: PLN02278 460265013074 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 460265013075 tetramerization interface [polypeptide binding]; other site 460265013076 NAD(P) binding site [chemical binding]; other site 460265013077 catalytic residues [active] 460265013078 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265013079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265013080 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 460265013081 putative dimerization interface [polypeptide binding]; other site 460265013082 hypothetical protein; Validated; Region: PRK08245 460265013083 galactarate dehydratase; Region: galactar-dH20; TIGR03248 460265013084 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 460265013085 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 460265013086 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 460265013087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265013088 putative substrate translocation pore; other site 460265013089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265013090 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 460265013091 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 460265013092 active site pocket [active] 460265013093 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 460265013094 active site 1 [active] 460265013095 dimer interface [polypeptide binding]; other site 460265013096 hexamer interface [polypeptide binding]; other site 460265013097 active site 2 [active] 460265013098 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265013099 DNA binding site [nucleotide binding] 460265013100 Predicted integral membrane protein [Function unknown]; Region: COG5616 460265013101 Protein of unknown function (DUF445); Region: DUF445; pfam04286 460265013102 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 460265013103 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 460265013104 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 460265013105 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 460265013106 Soluble P-type ATPase [General function prediction only]; Region: COG4087 460265013107 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 460265013108 Flp/Fap pilin component; Region: Flp_Fap; cl01585 460265013109 TadE-like protein; Region: TadE; pfam07811 460265013110 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 460265013111 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 460265013112 HPP family; Region: HPP; pfam04982 460265013113 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 460265013114 Rod binding protein; Region: Rod-binding; cl01626 460265013115 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 460265013116 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 460265013117 Class II flagellar assembly regulator; Region: FliX; cl11677 460265013118 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 460265013119 GcrA cell cycle regulator; Region: GcrA; cl11564 460265013120 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 460265013121 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 460265013122 SAF-like; Region: SAF_2; pfam13144 460265013123 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 460265013124 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 460265013125 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 460265013126 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 460265013127 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 460265013128 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 460265013129 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 460265013130 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK12785 460265013131 flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795 460265013132 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 460265013133 Uncharacterized conserved protein [Function unknown]; Region: COG3334 460265013134 TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli...; Region: TOPRIM_TopoIA; cd01028 460265013135 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 460265013136 active site 460265013137 interdomain interaction site; other site 460265013138 putative metal-binding site [ion binding]; other site 460265013139 nucleotide binding site [chemical binding]; other site 460265013140 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 460265013141 domain I; other site 460265013142 DNA binding groove [nucleotide binding] 460265013143 phosphate binding site [ion binding]; other site 460265013144 domain II; other site 460265013145 domain III; other site 460265013146 nucleotide binding site [chemical binding]; other site 460265013147 catalytic site [active] 460265013148 domain IV; other site 460265013149 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 460265013150 primary metal binding site; other site 460265013151 catalytic residues [active] 460265013152 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 460265013153 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 460265013154 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 460265013155 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 460265013156 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 460265013157 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 460265013158 GTPase CgtA; Reviewed; Region: obgE; PRK12299 460265013159 GTP1/OBG; Region: GTP1_OBG; pfam01018 460265013160 Obg GTPase; Region: Obg; cd01898 460265013161 G1 box; other site 460265013162 GTP/Mg2+ binding site [chemical binding]; other site 460265013163 Switch I region; other site 460265013164 G2 box; other site 460265013165 G3 box; other site 460265013166 Switch II region; other site 460265013167 G4 box; other site 460265013168 G5 box; other site 460265013169 gamma-glutamyl kinase; Provisional; Region: PRK05429 460265013170 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 460265013171 nucleotide binding site [chemical binding]; other site 460265013172 homotetrameric interface [polypeptide binding]; other site 460265013173 putative phosphate binding site [ion binding]; other site 460265013174 putative allosteric binding site; other site 460265013175 PUA domain; Region: PUA; pfam01472 460265013176 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 460265013177 putative catalytic cysteine [active] 460265013178 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 460265013179 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 460265013180 active site 460265013181 (T/H)XGH motif; other site 460265013182 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 460265013183 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 460265013184 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 460265013185 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 460265013186 Peptidase family M23; Region: Peptidase_M23; pfam01551 460265013187 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 460265013188 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 460265013189 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 460265013190 protein binding site [polypeptide binding]; other site 460265013191 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 460265013192 Catalytic dyad [active] 460265013193 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 460265013194 NodB motif; other site 460265013195 putative active site [active] 460265013196 putative catalytic site [active] 460265013197 Zn binding site [ion binding]; other site 460265013198 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 460265013199 putative active site [active] 460265013200 Ap4A binding site [chemical binding]; other site 460265013201 nudix motif; other site 460265013202 putative metal binding site [ion binding]; other site 460265013203 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 460265013204 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 460265013205 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 460265013206 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 460265013207 putative dimer interface [polypeptide binding]; other site 460265013208 Protein of unknown function (DUF1150); Region: DUF1150; cl11577 460265013209 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 460265013210 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 460265013211 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 460265013212 putative ADP-binding pocket [chemical binding]; other site 460265013213 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265013214 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 460265013215 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 460265013216 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 460265013217 AMP nucleosidase; Provisional; Region: PRK08292 460265013218 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 460265013219 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 460265013220 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 460265013221 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 460265013222 ATP binding site [chemical binding]; other site 460265013223 substrate interface [chemical binding]; other site 460265013224 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 460265013225 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 460265013226 metal binding site [ion binding]; metal-binding site 460265013227 dimer interface [polypeptide binding]; other site 460265013228 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 460265013229 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 460265013230 dimerization interface 3.5A [polypeptide binding]; other site 460265013231 active site 460265013232 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 460265013233 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 460265013234 putative active site [active] 460265013235 substrate binding site [chemical binding]; other site 460265013236 putative cosubstrate binding site; other site 460265013237 catalytic site [active] 460265013238 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 460265013239 substrate binding site [chemical binding]; other site 460265013240 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 460265013241 active site 460265013242 catalytic residues [active] 460265013243 metal binding site [ion binding]; metal-binding site 460265013244 recombination protein RecR; Reviewed; Region: recR; PRK00076 460265013245 RecR protein; Region: RecR; pfam02132 460265013246 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 460265013247 putative active site [active] 460265013248 putative metal-binding site [ion binding]; other site 460265013249 tetramer interface [polypeptide binding]; other site 460265013250 hypothetical protein; Validated; Region: PRK00153 460265013251 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 460265013252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265013253 Walker A motif; other site 460265013254 ATP binding site [chemical binding]; other site 460265013255 Walker B motif; other site 460265013256 arginine finger; other site 460265013257 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 460265013258 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 460265013259 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 460265013260 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 460265013261 active site 460265013262 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 460265013263 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 460265013264 AAA domain; Region: AAA_30; pfam13604 460265013265 Family description; Region: UvrD_C_2; pfam13538 460265013266 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 460265013267 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 460265013268 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 460265013269 minor groove reading motif; other site 460265013270 helix-hairpin-helix signature motif; other site 460265013271 substrate binding pocket [chemical binding]; other site 460265013272 active site 460265013273 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 460265013274 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 460265013275 putative active site [active] 460265013276 putative metal binding site [ion binding]; other site 460265013277 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 460265013278 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 460265013279 ATP binding site [chemical binding]; other site 460265013280 putative Mg++ binding site [ion binding]; other site 460265013281 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 460265013282 nucleotide binding region [chemical binding]; other site 460265013283 ATP-binding site [chemical binding]; other site 460265013284 DEAD/H associated; Region: DEAD_assoc; pfam08494 460265013285 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 460265013286 ribonuclease PH; Reviewed; Region: rph; PRK00173 460265013287 Ribonuclease PH; Region: RNase_PH_bact; cd11362 460265013288 hexamer interface [polypeptide binding]; other site 460265013289 active site 460265013290 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 460265013291 active site 460265013292 dimerization interface [polypeptide binding]; other site 460265013293 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 460265013294 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 460265013295 MarR family; Region: MarR; pfam01047 460265013296 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 460265013297 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 460265013298 FMN binding site [chemical binding]; other site 460265013299 active site 460265013300 substrate binding site [chemical binding]; other site 460265013301 catalytic residue [active] 460265013302 hypothetical protein; Provisional; Region: PRK09256 460265013303 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 460265013304 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 460265013305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265013306 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265013307 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265013308 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 460265013309 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 460265013310 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 460265013311 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 460265013312 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 460265013313 Subunit I/III interface [polypeptide binding]; other site 460265013314 Subunit III/IV interface [polypeptide binding]; other site 460265013315 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 460265013316 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 460265013317 D-pathway; other site 460265013318 Putative ubiquinol binding site [chemical binding]; other site 460265013319 Low-spin heme (heme b) binding site [chemical binding]; other site 460265013320 Putative water exit pathway; other site 460265013321 Binuclear center (heme o3/CuB) [ion binding]; other site 460265013322 K-pathway; other site 460265013323 Putative proton exit pathway; other site 460265013324 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 460265013325 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 460265013326 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 460265013327 metabolite-proton symporter; Region: 2A0106; TIGR00883 460265013328 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 460265013329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265013330 NAD(P) binding site [chemical binding]; other site 460265013331 active site 460265013332 putative acyltransferase; Provisional; Region: PRK05790 460265013333 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 460265013334 dimer interface [polypeptide binding]; other site 460265013335 active site 460265013336 acetyl-CoA synthetase; Provisional; Region: PRK00174 460265013337 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 460265013338 active site 460265013339 CoA binding site [chemical binding]; other site 460265013340 acyl-activating enzyme (AAE) consensus motif; other site 460265013341 AMP binding site [chemical binding]; other site 460265013342 acetate binding site [chemical binding]; other site 460265013343 Protein of unknown function, DUF485; Region: DUF485; pfam04341 460265013344 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 460265013345 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 460265013346 Na binding site [ion binding]; other site 460265013347 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 460265013348 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 460265013349 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 460265013350 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 460265013351 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265013352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265013353 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 460265013354 dimerization interface [polypeptide binding]; other site 460265013355 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 460265013356 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 460265013357 NAD binding site [chemical binding]; other site 460265013358 dimerization interface [polypeptide binding]; other site 460265013359 product binding site; other site 460265013360 substrate binding site [chemical binding]; other site 460265013361 zinc binding site [ion binding]; other site 460265013362 catalytic residues [active] 460265013363 hypothetical protein; Provisional; Region: PRK02853 460265013364 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 460265013365 Low molecular weight phosphatase family; Region: LMWPc; cl00105 460265013366 active site 460265013367 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 460265013368 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 460265013369 homodimer interface [polypeptide binding]; other site 460265013370 substrate-cofactor binding pocket; other site 460265013371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265013372 catalytic residue [active] 460265013373 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265013374 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265013375 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265013376 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 460265013377 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 460265013378 catalytic residues [active] 460265013379 catalytic nucleophile [active] 460265013380 Recombinase; Region: Recombinase; pfam07508 460265013381 Homeodomain-like domain; Region: HTH_23; cl17451 460265013382 Winged helix-turn helix; Region: HTH_29; pfam13551 460265013383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 460265013384 Integrase core domain; Region: rve; pfam00665 460265013385 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 460265013386 MgtE intracellular N domain; Region: MgtE_N; pfam03448 460265013387 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 460265013388 Divalent cation transporter; Region: MgtE; pfam01769 460265013389 Low affinity iron permease; Region: Iron_permease; pfam04120 460265013390 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 460265013391 Amidase; Region: Amidase; pfam01425 460265013392 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 460265013393 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 460265013394 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 460265013395 active site 460265013396 intersubunit interface [polypeptide binding]; other site 460265013397 catalytic residue [active] 460265013398 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 460265013399 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 460265013400 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 460265013401 catalytic residue [active] 460265013402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265013403 S-adenosylmethionine binding site [chemical binding]; other site 460265013404 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 460265013405 intersubunit interface [polypeptide binding]; other site 460265013406 active site 460265013407 Zn2+ binding site [ion binding]; other site 460265013408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265013409 active site 460265013410 phosphorylation site [posttranslational modification] 460265013411 intermolecular recognition site; other site 460265013412 dimerization interface [polypeptide binding]; other site 460265013413 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 460265013414 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 460265013415 homodimer interface [polypeptide binding]; other site 460265013416 substrate-cofactor binding pocket; other site 460265013417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265013418 catalytic residue [active] 460265013419 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 460265013420 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 460265013421 isocitrate dehydrogenase; Validated; Region: PRK08299 460265013422 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 460265013423 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 460265013424 active site 460265013425 dimer interface [polypeptide binding]; other site 460265013426 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 460265013427 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 460265013428 nucleotide binding site [chemical binding]; other site 460265013429 putative NEF/HSP70 interaction site [polypeptide binding]; other site 460265013430 SBD interface [polypeptide binding]; other site 460265013431 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 460265013432 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 460265013433 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265013434 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265013435 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 460265013436 catalytic loop [active] 460265013437 iron binding site [ion binding]; other site 460265013438 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 460265013439 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265013440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265013441 dimer interface [polypeptide binding]; other site 460265013442 phosphorylation site [posttranslational modification] 460265013443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265013444 ATP binding site [chemical binding]; other site 460265013445 Mg2+ binding site [ion binding]; other site 460265013446 G-X-G motif; other site 460265013447 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 460265013448 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 460265013449 putative C-terminal domain interface [polypeptide binding]; other site 460265013450 putative GSH binding site (G-site) [chemical binding]; other site 460265013451 putative dimer interface [polypeptide binding]; other site 460265013452 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 460265013453 N-terminal domain interface [polypeptide binding]; other site 460265013454 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 460265013455 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 460265013456 active site 460265013457 substrate binding site [chemical binding]; other site 460265013458 cosubstrate binding site; other site 460265013459 catalytic site [active] 460265013460 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 460265013461 substrate binding site [chemical binding]; other site 460265013462 formyl-coenzyme A transferase; Provisional; Region: PRK05398 460265013463 CoA-transferase family III; Region: CoA_transf_3; pfam02515 460265013464 Zeta toxin; Region: Zeta_toxin; pfam06414 460265013465 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 460265013466 nucleophile elbow; other site 460265013467 Patatin phospholipase; Region: DUF3734; pfam12536 460265013468 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 460265013469 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 460265013470 active site 460265013471 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 460265013472 Cytochrome P450; Region: p450; cl12078 460265013473 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265013474 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 460265013475 DNA binding residues [nucleotide binding] 460265013476 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 460265013477 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 460265013478 DNA binding residues [nucleotide binding] 460265013479 dimer interface [polypeptide binding]; other site 460265013480 putative metal binding site [ion binding]; other site 460265013481 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 460265013482 ligand-binding site [chemical binding]; other site 460265013483 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 460265013484 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 460265013485 PYR/PP interface [polypeptide binding]; other site 460265013486 dimer interface [polypeptide binding]; other site 460265013487 TPP binding site [chemical binding]; other site 460265013488 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 460265013489 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 460265013490 TPP-binding site; other site 460265013491 dimer interface [polypeptide binding]; other site 460265013492 putative hydrolase; Provisional; Region: PRK11460 460265013493 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 460265013494 formyl-coenzyme A transferase; Provisional; Region: PRK05398 460265013495 CoA-transferase family III; Region: CoA_transf_3; pfam02515 460265013496 PAS domain; Region: PAS_9; pfam13426 460265013497 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265013498 putative active site [active] 460265013499 heme pocket [chemical binding]; other site 460265013500 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265013501 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265013502 DNA-binding site [nucleotide binding]; DNA binding site 460265013503 FCD domain; Region: FCD; pfam07729 460265013504 hypothetical protein; Validated; Region: PRK00029 460265013505 Uncharacterized conserved protein [Function unknown]; Region: COG0397 460265013506 Transglycosylase SLT domain; Region: SLT_2; pfam13406 460265013507 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265013508 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265013509 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 460265013510 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 460265013511 dimerization interface [polypeptide binding]; other site 460265013512 metal binding site [ion binding]; metal-binding site 460265013513 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 460265013514 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 460265013515 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 460265013516 putative dimer interface [polypeptide binding]; other site 460265013517 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 460265013518 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 460265013519 active site 460265013520 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 460265013521 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 460265013522 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 460265013523 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 460265013524 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265013525 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265013526 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265013527 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265013528 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 460265013529 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 460265013530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265013531 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14736 460265013532 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 460265013533 gamma subunit interface [polypeptide binding]; other site 460265013534 epsilon subunit interface [polypeptide binding]; other site 460265013535 LBP interface [polypeptide binding]; other site 460265013536 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265013537 ligand binding site [chemical binding]; other site 460265013538 flexible hinge region; other site 460265013539 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 460265013540 putative switch regulator; other site 460265013541 non-specific DNA interactions [nucleotide binding]; other site 460265013542 DNA binding site [nucleotide binding] 460265013543 sequence specific DNA binding site [nucleotide binding]; other site 460265013544 putative cAMP binding site [chemical binding]; other site 460265013545 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 460265013546 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 460265013547 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 460265013548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265013549 NAD(P) binding site [chemical binding]; other site 460265013550 active site 460265013551 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265013552 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 460265013553 active site 460265013554 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 460265013555 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265013556 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 460265013557 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 460265013558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 460265013559 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 460265013560 Coenzyme A binding pocket [chemical binding]; other site 460265013561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 460265013562 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 460265013563 Phage Tail Collar Domain; Region: Collar; pfam07484 460265013564 Hint domain; Region: Hint_2; pfam13403 460265013565 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 460265013566 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265013567 substrate binding pocket [chemical binding]; other site 460265013568 membrane-bound complex binding site; other site 460265013569 hinge residues; other site 460265013570 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 460265013571 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 460265013572 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 460265013573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265013574 dimer interface [polypeptide binding]; other site 460265013575 conserved gate region; other site 460265013576 ABC-ATPase subunit interface; other site 460265013577 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 460265013578 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 460265013579 Walker A/P-loop; other site 460265013580 ATP binding site [chemical binding]; other site 460265013581 Q-loop/lid; other site 460265013582 ABC transporter signature motif; other site 460265013583 Walker B; other site 460265013584 D-loop; other site 460265013585 H-loop/switch region; other site 460265013586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265013587 TPR repeat; Region: TPR_11; pfam13414 460265013588 binding surface 460265013589 TPR motif; other site 460265013590 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 460265013591 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 460265013592 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 460265013593 trimer interface [polypeptide binding]; other site 460265013594 active site 460265013595 substrate binding site [chemical binding]; other site 460265013596 CoA binding site [chemical binding]; other site 460265013597 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 460265013598 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 460265013599 Walker A/P-loop; other site 460265013600 ATP binding site [chemical binding]; other site 460265013601 Q-loop/lid; other site 460265013602 ABC transporter signature motif; other site 460265013603 Walker B; other site 460265013604 D-loop; other site 460265013605 H-loop/switch region; other site 460265013606 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 460265013607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265013608 ABC-ATPase subunit interface; other site 460265013609 putative PBP binding loops; other site 460265013610 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 460265013611 NMT1-like family; Region: NMT1_2; pfam13379 460265013612 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 460265013613 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 460265013614 putative DNA binding site [nucleotide binding]; other site 460265013615 putative Zn2+ binding site [ion binding]; other site 460265013616 AsnC family; Region: AsnC_trans_reg; pfam01037 460265013617 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 460265013618 ATP-grasp domain; Region: ATP-grasp_4; cl17255 460265013619 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265013620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265013621 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 460265013622 putative dimerization interface [polypeptide binding]; other site 460265013623 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 460265013624 CoA-transferase family III; Region: CoA_transf_3; pfam02515 460265013625 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 460265013626 active site 460265013627 catalytic residues [active] 460265013628 metal binding site [ion binding]; metal-binding site 460265013629 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 460265013630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265013631 putative substrate translocation pore; other site 460265013632 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 460265013633 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 460265013634 dimer interface [polypeptide binding]; other site 460265013635 catalytic residues [active] 460265013636 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 460265013637 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 460265013638 putative metal binding site [ion binding]; other site 460265013639 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 460265013640 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 460265013641 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 460265013642 amidase catalytic site [active] 460265013643 Zn binding residues [ion binding]; other site 460265013644 substrate binding site [chemical binding]; other site 460265013645 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 460265013646 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 460265013647 homodimer interface [polypeptide binding]; other site 460265013648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265013649 catalytic residue [active] 460265013650 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 460265013651 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 460265013652 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 460265013653 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 460265013654 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 460265013655 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 460265013656 substrate binding pocket [chemical binding]; other site 460265013657 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 460265013658 B12 binding site [chemical binding]; other site 460265013659 cobalt ligand [ion binding]; other site 460265013660 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 460265013661 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 460265013662 FAD binding site [chemical binding]; other site 460265013663 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 460265013664 dimerization interface [polypeptide binding]; other site 460265013665 putative DNA binding site [nucleotide binding]; other site 460265013666 putative Zn2+ binding site [ion binding]; other site 460265013667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265013668 Methyltransferase domain; Region: Methyltransf_31; pfam13847 460265013669 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 460265013670 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 460265013671 putative [4Fe-4S] binding site [ion binding]; other site 460265013672 putative molybdopterin cofactor binding site [chemical binding]; other site 460265013673 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 460265013674 molybdopterin cofactor binding site; other site 460265013675 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 460265013676 active site 460265013677 multimer interface [polypeptide binding]; other site 460265013678 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 460265013679 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 460265013680 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 460265013681 C-terminal domain interface [polypeptide binding]; other site 460265013682 GSH binding site (G-site) [chemical binding]; other site 460265013683 dimer interface [polypeptide binding]; other site 460265013684 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 460265013685 N-terminal domain interface [polypeptide binding]; other site 460265013686 dimer interface [polypeptide binding]; other site 460265013687 substrate binding pocket (H-site) [chemical binding]; other site 460265013688 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 460265013689 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 460265013690 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 460265013691 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 460265013692 hinge; other site 460265013693 active site 460265013694 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 460265013695 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 460265013696 substrate-cofactor binding pocket; other site 460265013697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265013698 catalytic residue [active] 460265013699 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 460265013700 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 460265013701 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 460265013702 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 460265013703 motif 1; other site 460265013704 dimer interface [polypeptide binding]; other site 460265013705 active site 460265013706 motif 2; other site 460265013707 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 460265013708 active site 460265013709 motif 3; other site 460265013710 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 460265013711 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 460265013712 dimer interface [polypeptide binding]; other site 460265013713 motif 1; other site 460265013714 motif 2; other site 460265013715 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 460265013716 active site 460265013717 motif 3; other site 460265013718 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 460265013719 anticodon binding site; other site 460265013720 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 460265013721 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 460265013722 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265013723 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265013724 dimerization interface [polypeptide binding]; other site 460265013725 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 460265013726 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 460265013727 putative lipid kinase; Reviewed; Region: PRK13057 460265013728 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 460265013729 AP2 domain; Region: AP2; pfam00847 460265013730 Predicted membrane protein [Function unknown]; Region: COG2261 460265013731 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 460265013732 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 460265013733 homotrimer interaction site [polypeptide binding]; other site 460265013734 putative active site [active] 460265013735 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 460265013736 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 460265013737 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 460265013738 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265013739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265013740 active site 460265013741 phosphorylation site [posttranslational modification] 460265013742 intermolecular recognition site; other site 460265013743 dimerization interface [polypeptide binding]; other site 460265013744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265013745 DNA binding residues [nucleotide binding] 460265013746 dimerization interface [polypeptide binding]; other site 460265013747 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 460265013748 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 460265013749 Predicted permeases [General function prediction only]; Region: RarD; COG2962 460265013750 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 460265013751 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 460265013752 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 460265013753 Permease; Region: Permease; pfam02405 460265013754 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 460265013755 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 460265013756 Walker A/P-loop; other site 460265013757 ATP binding site [chemical binding]; other site 460265013758 Q-loop/lid; other site 460265013759 ABC transporter signature motif; other site 460265013760 Walker B; other site 460265013761 D-loop; other site 460265013762 H-loop/switch region; other site 460265013763 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 460265013764 mce related protein; Region: MCE; pfam02470 460265013765 Protein of unknown function (DUF330); Region: DUF330; cl01135 460265013766 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 460265013767 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 460265013768 dimer interface [polypeptide binding]; other site 460265013769 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265013770 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 460265013771 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265013772 non-specific DNA binding site [nucleotide binding]; other site 460265013773 salt bridge; other site 460265013774 sequence-specific DNA binding site [nucleotide binding]; other site 460265013775 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 460265013776 dimer interface [polypeptide binding]; other site 460265013777 substrate binding site [chemical binding]; other site 460265013778 ATP binding site [chemical binding]; other site 460265013779 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 460265013780 active site 460265013781 thiamine phosphate binding site [chemical binding]; other site 460265013782 pyrophosphate binding site [ion binding]; other site 460265013783 EamA-like transporter family; Region: EamA; cl17759 460265013784 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 460265013785 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 460265013786 putative active site [active] 460265013787 putative metal binding site [ion binding]; other site 460265013788 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 460265013789 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265013790 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 460265013791 putative cation:proton antiport protein; Provisional; Region: PRK10669 460265013792 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 460265013793 TrkA-N domain; Region: TrkA_N; pfam02254 460265013794 putative kinase; Provisional; Region: PRK09954 460265013795 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 460265013796 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 460265013797 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 460265013798 cofactor binding site; other site 460265013799 DNA binding site [nucleotide binding] 460265013800 substrate interaction site [chemical binding]; other site 460265013801 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 460265013802 additional DNA contacts [nucleotide binding]; other site 460265013803 mismatch recognition site; other site 460265013804 active site 460265013805 zinc binding site [ion binding]; other site 460265013806 DNA intercalation site [nucleotide binding]; other site 460265013807 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 460265013808 IHF - DNA interface [nucleotide binding]; other site 460265013809 IHF dimer interface [polypeptide binding]; other site 460265013810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265013811 S-adenosylmethionine binding site [chemical binding]; other site 460265013812 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 460265013813 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 460265013814 inhibitor site; inhibition site 460265013815 active site 460265013816 dimer interface [polypeptide binding]; other site 460265013817 catalytic residue [active] 460265013818 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 460265013819 Y-family of DNA polymerases; Region: PolY; cl12025 460265013820 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 460265013821 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265013822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265013823 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 460265013824 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 460265013825 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 460265013826 Catalytic site [active] 460265013827 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 460265013828 dimer interface [polypeptide binding]; other site 460265013829 ADP-ribose binding site [chemical binding]; other site 460265013830 active site 460265013831 nudix motif; other site 460265013832 metal binding site [ion binding]; metal-binding site 460265013833 Transposase domain (DUF772); Region: DUF772; pfam05598 460265013834 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265013835 Transposase, Mutator family; Region: Transposase_mut; pfam00872 460265013836 MULE transposase domain; Region: MULE; pfam10551 460265013837 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 460265013838 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 460265013839 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 460265013840 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 460265013841 active site 460265013842 dimer interface [polypeptide binding]; other site 460265013843 non-prolyl cis peptide bond; other site 460265013844 insertion regions; other site 460265013845 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 460265013846 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 460265013847 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 460265013848 catalytic residues [active] 460265013849 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 460265013850 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 460265013851 Flavin binding site [chemical binding]; other site 460265013852 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 460265013853 Integrase core domain; Region: rve; pfam00665 460265013854 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 460265013855 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 460265013856 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265013857 Winged helix-turn helix; Region: HTH_29; pfam13551 460265013858 Integrase core domain; Region: rve; pfam00665 460265013859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 460265013860 Integrase core domain; Region: rve_3; pfam13683 460265013861 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265013862 DNA-binding site [nucleotide binding]; DNA binding site 460265013863 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 460265013864 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 460265013865 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 460265013866 inhibitor site; inhibition site 460265013867 active site 460265013868 dimer interface [polypeptide binding]; other site 460265013869 catalytic residue [active] 460265013870 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 460265013871 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265013872 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265013873 DNA-binding site [nucleotide binding]; DNA binding site 460265013874 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 460265013875 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 460265013876 putative ligand binding site [chemical binding]; other site 460265013877 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 460265013878 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 460265013879 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265013880 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265013881 ligand binding site [chemical binding]; other site 460265013882 flexible hinge region; other site 460265013883 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 460265013884 non-specific DNA interactions [nucleotide binding]; other site 460265013885 DNA binding site [nucleotide binding] 460265013886 sequence specific DNA binding site [nucleotide binding]; other site 460265013887 putative cAMP binding site [chemical binding]; other site 460265013888 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265013889 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265013890 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265013891 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 460265013892 DDE domain; Region: DDE_Tnp_IS240; pfam13610 460265013893 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 460265013894 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 460265013895 catalytic residues [active] 460265013896 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 460265013897 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 460265013898 active site 460265013899 HIGH motif; other site 460265013900 nucleotide binding site [chemical binding]; other site 460265013901 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 460265013902 active site 460265013903 KMSKS motif; other site 460265013904 Integrase core domain; Region: rve; pfam00665 460265013905 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 460265013906 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 460265013907 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 460265013908 Phage-related protein, tail component [Function unknown]; Region: COG4733 460265013909 Putative phage tail protein; Region: Phage-tail_3; pfam13550 460265013910 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 460265013911 Interdomain contacts; other site 460265013912 Cytokine receptor motif; other site 460265013913 Phage-related protein, tail component [Function unknown]; Region: COG4723 460265013914 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 460265013915 Phage minor tail protein L; Region: Phage_tail_L; cl01908 460265013916 Phage minor tail protein; Region: Phage_min_tail; cl01940 460265013917 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 460265013918 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265013919 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265013920 catalytic residue [active] 460265013921 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 460265013922 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 460265013923 Phage-related protein [Function unknown]; Region: COG4695 460265013924 Phage portal protein; Region: Phage_portal; pfam04860 460265013925 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 460265013926 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 460265013927 Phage capsid family; Region: Phage_capsid; pfam05065 460265013928 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 460265013929 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 460265013930 active site 460265013931 transcriptional activator RfaH; Region: RfaH; TIGR01955 460265013932 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 460265013933 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 460265013934 heterodimer interface [polypeptide binding]; other site 460265013935 homodimer interface [polypeptide binding]; other site 460265013936 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265013937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265013938 Walker A motif; other site 460265013939 ATP binding site [chemical binding]; other site 460265013940 Part of AAA domain; Region: AAA_19; pfam13245 460265013941 Family description; Region: UvrD_C_2; pfam13538 460265013942 MT-A70; Region: MT-A70; cl01947 460265013943 VRR-NUC domain; Region: VRR_NUC; pfam08774 460265013944 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265013945 non-specific DNA binding site [nucleotide binding]; other site 460265013946 salt bridge; other site 460265013947 sequence-specific DNA binding site [nucleotide binding]; other site 460265013948 exonuclease VIII; Reviewed; Region: PRK09709 460265013949 RecT family; Region: RecT; cl04285 460265013950 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 460265013951 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 460265013952 Helix-turn-helix domain; Region: HTH_17; pfam12728 460265013953 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 460265013954 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 460265013955 active site 460265013956 Int/Topo IB signature motif; other site 460265013957 Cupin domain; Region: Cupin_2; cl17218 460265013958 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 460265013959 ABC1 family; Region: ABC1; pfam03109 460265013960 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 460265013961 active site 460265013962 ATP binding site [chemical binding]; other site 460265013963 Transglycosylase; Region: Transgly; pfam00912 460265013964 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 460265013965 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265013966 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265013967 putative ligand binding site [chemical binding]; other site 460265013968 Putative cyclase; Region: Cyclase; cl00814 460265013969 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 460265013970 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 460265013971 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265013972 FeS/SAM binding site; other site 460265013973 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 460265013974 Isochorismatase family; Region: Isochorismatase; pfam00857 460265013975 catalytic triad [active] 460265013976 metal binding site [ion binding]; metal-binding site 460265013977 conserved cis-peptide bond; other site 460265013978 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 460265013979 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 460265013980 NADP binding site [chemical binding]; other site 460265013981 dimer interface [polypeptide binding]; other site 460265013982 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 460265013983 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 460265013984 hypothetical protein; Provisional; Region: PRK10279 460265013985 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 460265013986 nucleophile elbow; other site 460265013987 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 460265013988 FOG: CBS domain [General function prediction only]; Region: COG0517 460265013989 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 460265013990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 460265013991 PilZ domain; Region: PilZ; pfam07238 460265013992 PilZ domain; Region: PilZ; pfam07238 460265013993 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 460265013994 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 460265013995 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 460265013996 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 460265013997 catalytic site [active] 460265013998 putative active site [active] 460265013999 putative substrate binding site [chemical binding]; other site 460265014000 HRDC domain; Region: HRDC; pfam00570 460265014001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265014002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265014003 WHG domain; Region: WHG; pfam13305 460265014004 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 460265014005 Cytochrome P450; Region: p450; cl12078 460265014006 phosphopentomutase; Provisional; Region: PRK05362 460265014007 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 460265014008 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 460265014009 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265014010 Walker A/P-loop; other site 460265014011 ATP binding site [chemical binding]; other site 460265014012 Q-loop/lid; other site 460265014013 ABC transporter signature motif; other site 460265014014 Walker B; other site 460265014015 D-loop; other site 460265014016 H-loop/switch region; other site 460265014017 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 460265014018 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265014019 Q-loop/lid; other site 460265014020 ABC transporter signature motif; other site 460265014021 Walker B; other site 460265014022 D-loop; other site 460265014023 H-loop/switch region; other site 460265014024 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 460265014025 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265014026 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265014027 catalytic residue [active] 460265014028 Sporulation related domain; Region: SPOR; cl10051 460265014029 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 460265014030 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 460265014031 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265014032 putative metal binding site [ion binding]; other site 460265014033 transcriptional regulator; Provisional; Region: PRK10632 460265014034 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265014035 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 460265014036 putative effector binding pocket; other site 460265014037 dimerization interface [polypeptide binding]; other site 460265014038 excinuclease ABC subunit B; Provisional; Region: PRK05298 460265014039 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 460265014040 ATP binding site [chemical binding]; other site 460265014041 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 460265014042 nucleotide binding region [chemical binding]; other site 460265014043 ATP-binding site [chemical binding]; other site 460265014044 Ultra-violet resistance protein B; Region: UvrB; pfam12344 460265014045 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 460265014046 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 460265014047 Walker A/P-loop; other site 460265014048 ATP binding site [chemical binding]; other site 460265014049 Q-loop/lid; other site 460265014050 ABC transporter signature motif; other site 460265014051 Walker B; other site 460265014052 D-loop; other site 460265014053 H-loop/switch region; other site 460265014054 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 460265014055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265014056 dimer interface [polypeptide binding]; other site 460265014057 conserved gate region; other site 460265014058 putative PBP binding loops; other site 460265014059 ABC-ATPase subunit interface; other site 460265014060 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 460265014061 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 460265014062 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 460265014063 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 460265014064 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 460265014065 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 460265014066 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265014067 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265014068 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 460265014069 Protein export membrane protein; Region: SecD_SecF; cl14618 460265014070 RNA polymerase sigma factor; Provisional; Region: PRK12547 460265014071 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265014072 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 460265014073 DNA binding residues [nucleotide binding] 460265014074 Uncharacterized conserved protein [Function unknown]; Region: COG4544 460265014075 DNA Polymerase Y-family; Region: PolY_like; cd03468 460265014076 active site 460265014077 DNA binding site [nucleotide binding] 460265014078 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 460265014079 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 460265014080 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 460265014081 putative active site [active] 460265014082 putative PHP Thumb interface [polypeptide binding]; other site 460265014083 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 460265014084 generic binding surface II; other site 460265014085 generic binding surface I; other site 460265014086 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 460265014087 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 460265014088 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 460265014089 NAD binding site [chemical binding]; other site 460265014090 catalytic Zn binding site [ion binding]; other site 460265014091 structural Zn binding site [ion binding]; other site 460265014092 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 460265014093 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 460265014094 Walker A/P-loop; other site 460265014095 ATP binding site [chemical binding]; other site 460265014096 Q-loop/lid; other site 460265014097 ABC transporter signature motif; other site 460265014098 Walker B; other site 460265014099 D-loop; other site 460265014100 H-loop/switch region; other site 460265014101 NIL domain; Region: NIL; pfam09383 460265014102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265014103 dimer interface [polypeptide binding]; other site 460265014104 conserved gate region; other site 460265014105 ABC-ATPase subunit interface; other site 460265014106 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 460265014107 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 460265014108 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 460265014109 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 460265014110 Walker A/P-loop; other site 460265014111 ATP binding site [chemical binding]; other site 460265014112 Q-loop/lid; other site 460265014113 ABC transporter signature motif; other site 460265014114 Walker B; other site 460265014115 D-loop; other site 460265014116 H-loop/switch region; other site 460265014117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265014118 dimer interface [polypeptide binding]; other site 460265014119 conserved gate region; other site 460265014120 putative PBP binding loops; other site 460265014121 ABC-ATPase subunit interface; other site 460265014122 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 460265014123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265014124 dimer interface [polypeptide binding]; other site 460265014125 conserved gate region; other site 460265014126 putative PBP binding loops; other site 460265014127 ABC-ATPase subunit interface; other site 460265014128 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265014129 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 460265014130 substrate binding pocket [chemical binding]; other site 460265014131 membrane-bound complex binding site; other site 460265014132 hinge residues; other site 460265014133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 460265014134 Coenzyme A binding pocket [chemical binding]; other site 460265014135 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 460265014136 Aerotolerance regulator N-terminal; Region: BatA; cl06567 460265014137 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 460265014138 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 460265014139 Protein of unknown function DUF58; Region: DUF58; pfam01882 460265014140 MoxR-like ATPases [General function prediction only]; Region: COG0714 460265014141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 460265014142 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 460265014143 CoenzymeA binding site [chemical binding]; other site 460265014144 subunit interaction site [polypeptide binding]; other site 460265014145 PHB binding site; other site 460265014146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 460265014147 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 460265014148 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 460265014149 putative active site [active] 460265014150 putative CoA binding site [chemical binding]; other site 460265014151 nudix motif; other site 460265014152 metal binding site [ion binding]; metal-binding site 460265014153 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 460265014154 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 460265014155 active site 460265014156 NTP binding site [chemical binding]; other site 460265014157 metal binding triad [ion binding]; metal-binding site 460265014158 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 460265014159 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265014160 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265014161 DNA binding residues [nucleotide binding] 460265014162 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 460265014163 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 460265014164 FAD binding domain; Region: FAD_binding_4; pfam01565 460265014165 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 460265014166 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 460265014167 FAD binding pocket [chemical binding]; other site 460265014168 FAD binding motif [chemical binding]; other site 460265014169 phosphate binding motif [ion binding]; other site 460265014170 beta-alpha-beta structure motif; other site 460265014171 NAD binding pocket [chemical binding]; other site 460265014172 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 460265014173 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 460265014174 Moco binding site; other site 460265014175 metal coordination site [ion binding]; other site 460265014176 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 460265014177 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 460265014178 dimer interface [polypeptide binding]; other site 460265014179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265014180 catalytic residue [active] 460265014181 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 460265014182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265014183 Walker A/P-loop; other site 460265014184 ATP binding site [chemical binding]; other site 460265014185 Q-loop/lid; other site 460265014186 ABC transporter signature motif; other site 460265014187 Walker B; other site 460265014188 D-loop; other site 460265014189 H-loop/switch region; other site 460265014190 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 460265014191 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 460265014192 catalytic residues [active] 460265014193 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 460265014194 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 460265014195 active site 460265014196 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 460265014197 active site 460265014198 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 460265014199 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 460265014200 active site 460265014201 (T/H)XGH motif; other site 460265014202 Predicted periplasmic protein [Function unknown]; Region: COG3698 460265014203 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 460265014204 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 460265014205 Prostaglandin dehydrogenases; Region: PGDH; cd05288 460265014206 NAD(P) binding site [chemical binding]; other site 460265014207 substrate binding site [chemical binding]; other site 460265014208 dimer interface [polypeptide binding]; other site 460265014209 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265014210 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265014211 catalytic residue [active] 460265014212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 460265014213 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 460265014214 Phasin protein; Region: Phasin_2; cl11491 460265014215 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 460265014216 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265014217 putative active site [active] 460265014218 heme pocket [chemical binding]; other site 460265014219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265014220 dimer interface [polypeptide binding]; other site 460265014221 phosphorylation site [posttranslational modification] 460265014222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265014223 ATP binding site [chemical binding]; other site 460265014224 Mg2+ binding site [ion binding]; other site 460265014225 G-X-G motif; other site 460265014226 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265014227 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 460265014228 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 460265014229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265014230 putative substrate translocation pore; other site 460265014231 acetyl-CoA synthetase; Provisional; Region: PRK00174 460265014232 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 460265014233 active site 460265014234 CoA binding site [chemical binding]; other site 460265014235 acyl-activating enzyme (AAE) consensus motif; other site 460265014236 AMP binding site [chemical binding]; other site 460265014237 acetate binding site [chemical binding]; other site 460265014238 Protein of unknown function, DUF485; Region: DUF485; pfam04341 460265014239 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 460265014240 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 460265014241 Na binding site [ion binding]; other site 460265014242 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 460265014243 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 460265014244 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 460265014245 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265014246 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 460265014247 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 460265014248 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 460265014249 Chain length determinant protein; Region: Wzz; pfam02706 460265014250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 460265014251 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 460265014252 Cupin domain; Region: Cupin_2; pfam07883 460265014253 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 460265014254 pentamer interface [polypeptide binding]; other site 460265014255 dodecaamer interface [polypeptide binding]; other site 460265014256 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 460265014257 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 460265014258 16S rRNA methyltransferase B; Provisional; Region: PRK10901 460265014259 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 460265014260 putative RNA binding site [nucleotide binding]; other site 460265014261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265014262 S-adenosylmethionine binding site [chemical binding]; other site 460265014263 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 460265014264 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 460265014265 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 460265014266 purine monophosphate binding site [chemical binding]; other site 460265014267 dimer interface [polypeptide binding]; other site 460265014268 putative catalytic residues [active] 460265014269 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 460265014270 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 460265014271 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 460265014272 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 460265014273 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265014274 catalytic loop [active] 460265014275 iron binding site [ion binding]; other site 460265014276 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 460265014277 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 460265014278 [4Fe-4S] binding site [ion binding]; other site 460265014279 molybdopterin cofactor binding site; other site 460265014280 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 460265014281 molybdopterin cofactor binding site; other site 460265014282 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 460265014283 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 460265014284 putative dimer interface [polypeptide binding]; other site 460265014285 [2Fe-2S] cluster binding site [ion binding]; other site 460265014286 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 460265014287 SLBB domain; Region: SLBB; pfam10531 460265014288 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 460265014289 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 460265014290 Ligand Binding Site [chemical binding]; other site 460265014291 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 460265014292 Low-spin heme binding site [chemical binding]; other site 460265014293 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 460265014294 Putative water exit pathway; other site 460265014295 Binuclear center (active site) [active] 460265014296 Putative proton exit pathway; other site 460265014297 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 460265014298 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 460265014299 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 460265014300 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 460265014301 Cytochrome c; Region: Cytochrom_C; pfam00034 460265014302 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 460265014303 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 460265014304 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 460265014305 dimer interface [polypeptide binding]; other site 460265014306 putative functional site; other site 460265014307 putative MPT binding site; other site 460265014308 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 460265014309 Walker A motif; other site 460265014310 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 460265014311 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 460265014312 dimer interface [polypeptide binding]; other site 460265014313 putative functional site; other site 460265014314 putative MPT binding site; other site 460265014315 PBP superfamily domain; Region: PBP_like; pfam12727 460265014316 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 460265014317 MPT binding site; other site 460265014318 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 460265014319 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 460265014320 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 460265014321 active site 460265014322 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 460265014323 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 460265014324 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 460265014325 dimer interface [polypeptide binding]; other site 460265014326 active site 460265014327 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 460265014328 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265014329 substrate binding site [chemical binding]; other site 460265014330 oxyanion hole (OAH) forming residues; other site 460265014331 trimer interface [polypeptide binding]; other site 460265014332 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 460265014333 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 460265014334 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 460265014335 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 460265014336 dimer interface [polypeptide binding]; other site 460265014337 putative CheW interface [polypeptide binding]; other site 460265014338 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 460265014339 homotrimer interaction site [polypeptide binding]; other site 460265014340 putative active site [active] 460265014341 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265014342 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265014343 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265014344 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 460265014345 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 460265014346 MarR family; Region: MarR; pfam01047 460265014347 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 460265014348 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 460265014349 tetramer interface [polypeptide binding]; other site 460265014350 heme binding pocket [chemical binding]; other site 460265014351 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 460265014352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265014353 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 460265014354 dimerization interface [polypeptide binding]; other site 460265014355 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 460265014356 Putative ammonia monooxygenase; Region: AmoA; pfam05145 460265014357 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 460265014358 threonine dehydratase; Reviewed; Region: PRK09224 460265014359 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 460265014360 tetramer interface [polypeptide binding]; other site 460265014361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265014362 catalytic residue [active] 460265014363 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 460265014364 putative Ile/Val binding site [chemical binding]; other site 460265014365 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 460265014366 putative Ile/Val binding site [chemical binding]; other site 460265014367 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 460265014368 Uncharacterized conserved protein [Function unknown]; Region: COG1565 460265014369 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 460265014370 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 460265014371 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 460265014372 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 460265014373 dimerization interface [polypeptide binding]; other site 460265014374 metal binding site [ion binding]; metal-binding site 460265014375 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265014376 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 460265014377 putative metal binding site [ion binding]; other site 460265014378 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 460265014379 cyclase homology domain; Region: CHD; cd07302 460265014380 nucleotidyl binding site; other site 460265014381 metal binding site [ion binding]; metal-binding site 460265014382 dimer interface [polypeptide binding]; other site 460265014383 Glucokinase; Region: Glucokinase; cl17310 460265014384 glucokinase, proteobacterial type; Region: glk; TIGR00749 460265014385 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 460265014386 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 460265014387 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 460265014388 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 460265014389 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 460265014390 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 460265014391 primary metal binding site; other site 460265014392 catalytic residues [active] 460265014393 choline dehydrogenase; Validated; Region: PRK02106 460265014394 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 460265014395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 460265014396 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 460265014397 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 460265014398 homodimer interface [polypeptide binding]; other site 460265014399 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 460265014400 active site pocket [active] 460265014401 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 460265014402 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 460265014403 active site 460265014404 catalytic site [active] 460265014405 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 460265014406 glycogen synthase; Provisional; Region: glgA; PRK00654 460265014407 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 460265014408 ADP-binding pocket [chemical binding]; other site 460265014409 homodimer interface [polypeptide binding]; other site 460265014410 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 460265014411 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 460265014412 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 460265014413 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 460265014414 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 460265014415 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 460265014416 [4Fe-4S] binding site [ion binding]; other site 460265014417 molybdopterin cofactor binding site; other site 460265014418 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 460265014419 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 460265014420 molybdopterin cofactor binding site; other site 460265014421 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 460265014422 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 460265014423 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 460265014424 Predicted esterase [General function prediction only]; Region: COG0400 460265014425 putative hydrolase; Provisional; Region: PRK11460 460265014426 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 460265014427 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265014428 Zn binding site [ion binding]; other site 460265014429 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 460265014430 Zn binding site [ion binding]; other site 460265014431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265014432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265014433 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 460265014434 putative effector binding pocket; other site 460265014435 dimerization interface [polypeptide binding]; other site 460265014436 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 460265014437 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 460265014438 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 460265014439 Sel1-like repeats; Region: SEL1; smart00671 460265014440 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 460265014441 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 460265014442 DNA binding residues [nucleotide binding] 460265014443 putative dimer interface [polypeptide binding]; other site 460265014444 Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546 460265014445 dinuclear metal binding motif [ion binding]; other site 460265014446 FOG: WD40 repeat [General function prediction only]; Region: COG2319 460265014447 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 460265014448 structural tetrad; other site 460265014449 Cytochrome c; Region: Cytochrom_C; cl11414 460265014450 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 460265014451 Lumazine binding domain; Region: Lum_binding; pfam00677 460265014452 Lumazine binding domain; Region: Lum_binding; pfam00677 460265014453 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 460265014454 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 460265014455 catalytic motif [active] 460265014456 Zn binding site [ion binding]; other site 460265014457 RibD C-terminal domain; Region: RibD_C; cl17279 460265014458 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 460265014459 ATP cone domain; Region: ATP-cone; pfam03477 460265014460 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 460265014461 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 460265014462 dimer interface [polypeptide binding]; other site 460265014463 active site 460265014464 glycine-pyridoxal phosphate binding site [chemical binding]; other site 460265014465 folate binding site [chemical binding]; other site 460265014466 SlyX; Region: SlyX; pfam04102 460265014467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 460265014468 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 460265014469 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 460265014470 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 460265014471 Protein of unknown function (DUF461); Region: DUF461; pfam04314 460265014472 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 460265014473 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 460265014474 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 460265014475 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 460265014476 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 460265014477 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265014478 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 460265014479 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265014480 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 460265014481 nudix motif; other site 460265014482 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 460265014483 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 460265014484 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 460265014485 FAD binding domain; Region: FAD_binding_4; pfam01565 460265014486 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 460265014487 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 460265014488 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 460265014489 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 460265014490 ABC-2 type transporter; Region: ABC2_membrane; cl17235 460265014491 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 460265014492 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 460265014493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265014494 Walker A/P-loop; other site 460265014495 ATP binding site [chemical binding]; other site 460265014496 Q-loop/lid; other site 460265014497 ABC transporter signature motif; other site 460265014498 Walker B; other site 460265014499 D-loop; other site 460265014500 H-loop/switch region; other site 460265014501 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 460265014502 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 460265014503 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 460265014504 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 460265014505 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 460265014506 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265014507 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 460265014508 ligand binding site [chemical binding]; other site 460265014509 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 460265014510 hypothetical protein; Provisional; Region: PRK02227 460265014511 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 460265014512 nucleotide binding site [chemical binding]; other site 460265014513 substrate binding site [chemical binding]; other site 460265014514 dihydropteroate synthase-related protein; Region: TIGR00284 460265014515 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 460265014516 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 460265014517 Protein of unknown function (DUF447); Region: DUF447; pfam04289 460265014518 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 460265014519 putative hydrophobic ligand binding site [chemical binding]; other site 460265014520 protein interface [polypeptide binding]; other site 460265014521 gate; other site 460265014522 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 460265014523 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 460265014524 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 460265014525 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12813 460265014526 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 460265014527 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 460265014528 putative ligand binding site [chemical binding]; other site 460265014529 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 460265014530 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265014531 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 460265014532 TM-ABC transporter signature motif; other site 460265014533 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 460265014534 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265014535 TM-ABC transporter signature motif; other site 460265014536 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265014537 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265014538 Walker A/P-loop; other site 460265014539 ATP binding site [chemical binding]; other site 460265014540 Q-loop/lid; other site 460265014541 ABC transporter signature motif; other site 460265014542 Walker B; other site 460265014543 D-loop; other site 460265014544 H-loop/switch region; other site 460265014545 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265014546 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265014547 Walker A/P-loop; other site 460265014548 ATP binding site [chemical binding]; other site 460265014549 Q-loop/lid; other site 460265014550 ABC transporter signature motif; other site 460265014551 Walker B; other site 460265014552 D-loop; other site 460265014553 H-loop/switch region; other site 460265014554 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 460265014555 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 460265014556 active site 460265014557 dimer interface [polypeptide binding]; other site 460265014558 non-prolyl cis peptide bond; other site 460265014559 insertion regions; other site 460265014560 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 460265014561 catalytic residues [active] 460265014562 dimer interface [polypeptide binding]; other site 460265014563 Caspase domain; Region: Peptidase_C14; pfam00656 460265014564 substrate pocket [chemical binding]; other site 460265014565 active site 460265014566 proteolytic cleavage site; other site 460265014567 dimer interface [polypeptide binding]; other site 460265014568 Uncharacterized conserved protein [Function unknown]; Region: COG1262 460265014569 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 460265014570 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 460265014571 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 460265014572 Caspase domain; Region: Peptidase_C14; pfam00656 460265014573 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 460265014574 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 460265014575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 460265014576 SnoaL-like domain; Region: SnoaL_2; pfam12680 460265014577 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 460265014578 hypothetical protein; Provisional; Region: PRK07338 460265014579 metal binding site [ion binding]; metal-binding site 460265014580 dimer interface [polypeptide binding]; other site 460265014581 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 460265014582 Zn2+ binding site [ion binding]; other site 460265014583 Mg2+ binding site [ion binding]; other site 460265014584 Transcriptional regulator; Region: Rrf2; pfam02082 460265014585 Predicted transcriptional regulator [Transcription]; Region: COG1959 460265014586 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 460265014587 trimer interface [polypeptide binding]; other site 460265014588 active site 460265014589 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265014590 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265014591 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265014592 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265014593 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265014594 DNA-binding site [nucleotide binding]; DNA binding site 460265014595 FCD domain; Region: FCD; pfam07729 460265014596 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 460265014597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265014598 putative substrate translocation pore; other site 460265014599 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 460265014600 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 460265014601 active site 460265014602 homodimer interface [polypeptide binding]; other site 460265014603 homotetramer interface [polypeptide binding]; other site 460265014604 Response regulator receiver domain; Region: Response_reg; pfam00072 460265014605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265014606 active site 460265014607 phosphorylation site [posttranslational modification] 460265014608 intermolecular recognition site; other site 460265014609 dimerization interface [polypeptide binding]; other site 460265014610 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 460265014611 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 460265014612 metal binding site [ion binding]; metal-binding site 460265014613 active site 460265014614 I-site; other site 460265014615 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265014616 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265014617 DNA binding residues [nucleotide binding] 460265014618 dimerization interface [polypeptide binding]; other site 460265014619 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 460265014620 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 460265014621 active site 460265014622 DNA binding site [nucleotide binding] 460265014623 Int/Topo IB signature motif; other site 460265014624 catalytic residues [active] 460265014625 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 460265014626 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265014627 Predicted methyltransferase [General function prediction only]; Region: COG3897 460265014628 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 460265014629 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 460265014630 nucleophile elbow; other site 460265014631 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 460265014632 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 460265014633 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 460265014634 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 460265014635 potassium uptake protein; Region: kup; TIGR00794 460265014636 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 460265014637 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 460265014638 homodimer interface [polypeptide binding]; other site 460265014639 active site 460265014640 TDP-binding site; other site 460265014641 acceptor substrate-binding pocket; other site 460265014642 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 460265014643 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265014644 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 460265014645 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 460265014646 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 460265014647 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265014648 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 460265014649 active site residue [active] 460265014650 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 460265014651 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265014652 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 460265014653 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 460265014654 active site 460265014655 catalytic site [active] 460265014656 tetramer interface [polypeptide binding]; other site 460265014657 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 460265014658 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 460265014659 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 460265014660 C-terminal domain interface [polypeptide binding]; other site 460265014661 GSH binding site (G-site) [chemical binding]; other site 460265014662 dimer interface [polypeptide binding]; other site 460265014663 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 460265014664 substrate binding pocket (H-site) [chemical binding]; other site 460265014665 N-terminal domain interface [polypeptide binding]; other site 460265014666 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 460265014667 Sel1-like repeats; Region: SEL1; smart00671 460265014668 Sel1-like repeats; Region: SEL1; smart00671 460265014669 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 460265014670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 460265014671 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 460265014672 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 460265014673 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 460265014674 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 460265014675 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 460265014676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 460265014677 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 460265014678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 460265014679 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 460265014680 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 460265014681 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 460265014682 Protein of unknown function (DUF1192); Region: DUF1192; cl11573 460265014683 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 460265014684 Ribonuclease P; Region: Ribonuclease_P; cl00457 460265014685 membrane protein insertase; Provisional; Region: PRK01318 460265014686 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 460265014687 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 460265014688 G1 box; other site 460265014689 GTP/Mg2+ binding site [chemical binding]; other site 460265014690 Switch I region; other site 460265014691 G2 box; other site 460265014692 G3 box; other site 460265014693 Switch II region; other site 460265014694 G4 box; other site 460265014695 G5 box; other site 460265014696 Protein of unknown function (DUF423); Region: DUF423; cl01008 460265014697 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 460265014698 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 460265014699 active site 460265014700 metal binding site [ion binding]; metal-binding site 460265014701 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 460265014702 Clp amino terminal domain; Region: Clp_N; pfam02861 460265014703 Clp amino terminal domain; Region: Clp_N; pfam02861 460265014704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265014705 Walker A motif; other site 460265014706 ATP binding site [chemical binding]; other site 460265014707 Walker B motif; other site 460265014708 arginine finger; other site 460265014709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265014710 Walker A motif; other site 460265014711 ATP binding site [chemical binding]; other site 460265014712 Walker B motif; other site 460265014713 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 460265014714 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 460265014715 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 460265014716 MOSC domain; Region: MOSC; pfam03473 460265014717 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 460265014718 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265014719 ligand binding site [chemical binding]; other site 460265014720 flexible hinge region; other site 460265014721 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 460265014722 putative switch regulator; other site 460265014723 non-specific DNA interactions [nucleotide binding]; other site 460265014724 DNA binding site [nucleotide binding] 460265014725 sequence specific DNA binding site [nucleotide binding]; other site 460265014726 putative cAMP binding site [chemical binding]; other site 460265014727 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 460265014728 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 460265014729 putative NAD(P) binding site [chemical binding]; other site 460265014730 putative substrate binding site [chemical binding]; other site 460265014731 catalytic Zn binding site [ion binding]; other site 460265014732 structural Zn binding site [ion binding]; other site 460265014733 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 460265014734 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 460265014735 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 460265014736 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 460265014737 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 460265014738 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 460265014739 Walker A motif; other site 460265014740 ATP binding site [chemical binding]; other site 460265014741 Walker B motif; other site 460265014742 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 460265014743 multiple promoter invertase; Provisional; Region: mpi; PRK13413 460265014744 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 460265014745 catalytic residues [active] 460265014746 catalytic nucleophile [active] 460265014747 Presynaptic Site I dimer interface [polypeptide binding]; other site 460265014748 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 460265014749 Synaptic Flat tetramer interface [polypeptide binding]; other site 460265014750 Synaptic Site I dimer interface [polypeptide binding]; other site 460265014751 DNA binding site [nucleotide binding] 460265014752 Divergent AAA domain; Region: AAA_4; pfam04326 460265014753 putative ssRNA endonuclease; Provisional; Region: PRK11558 460265014754 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 460265014755 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 460265014756 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 460265014757 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 460265014758 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 460265014759 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 460265014760 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 460265014761 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 460265014762 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 460265014763 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 460265014764 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 460265014765 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 460265014766 Int/Topo IB signature motif; other site 460265014767 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 460265014768 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 460265014769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265014770 Walker A motif; other site 460265014771 ATP binding site [chemical binding]; other site 460265014772 Walker B motif; other site 460265014773 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 460265014774 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 460265014775 PAS domain; Region: PAS; smart00091 460265014776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265014777 dimer interface [polypeptide binding]; other site 460265014778 phosphorylation site [posttranslational modification] 460265014779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265014780 ATP binding site [chemical binding]; other site 460265014781 Mg2+ binding site [ion binding]; other site 460265014782 G-X-G motif; other site 460265014783 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 460265014784 putative NAD(P) binding site [chemical binding]; other site 460265014785 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 460265014786 epoxyqueuosine reductase; Region: TIGR00276 460265014787 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 460265014788 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 460265014789 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 460265014790 C-terminal domain interface [polypeptide binding]; other site 460265014791 GSH binding site (G-site) [chemical binding]; other site 460265014792 dimer interface [polypeptide binding]; other site 460265014793 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 460265014794 N-terminal domain interface [polypeptide binding]; other site 460265014795 dimer interface [polypeptide binding]; other site 460265014796 substrate binding pocket (H-site) [chemical binding]; other site 460265014797 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 460265014798 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 460265014799 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 460265014800 heterodimer interface [polypeptide binding]; other site 460265014801 substrate interaction site [chemical binding]; other site 460265014802 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 460265014803 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 460265014804 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265014805 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265014806 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265014807 GTP-binding protein LepA; Provisional; Region: PRK05433 460265014808 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 460265014809 G1 box; other site 460265014810 putative GEF interaction site [polypeptide binding]; other site 460265014811 GTP/Mg2+ binding site [chemical binding]; other site 460265014812 Switch I region; other site 460265014813 G2 box; other site 460265014814 G3 box; other site 460265014815 Switch II region; other site 460265014816 G4 box; other site 460265014817 G5 box; other site 460265014818 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 460265014819 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 460265014820 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 460265014821 Predicted dehydrogenase [General function prediction only]; Region: COG0579 460265014822 hydroxyglutarate oxidase; Provisional; Region: PRK11728 460265014823 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 460265014824 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 460265014825 active site 460265014826 substrate-binding site [chemical binding]; other site 460265014827 metal-binding site [ion binding] 460265014828 ATP binding site [chemical binding]; other site 460265014829 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 460265014830 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 460265014831 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 460265014832 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 460265014833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265014834 active site 460265014835 phosphorylation site [posttranslational modification] 460265014836 intermolecular recognition site; other site 460265014837 dimerization interface [polypeptide binding]; other site 460265014838 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265014839 DNA binding site [nucleotide binding] 460265014840 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 460265014841 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 460265014842 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265014843 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 460265014844 dimerization interface [polypeptide binding]; other site 460265014845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265014846 dimer interface [polypeptide binding]; other site 460265014847 phosphorylation site [posttranslational modification] 460265014848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265014849 ATP binding site [chemical binding]; other site 460265014850 Mg2+ binding site [ion binding]; other site 460265014851 G-X-G motif; other site 460265014852 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 460265014853 Hpr binding site; other site 460265014854 active site 460265014855 homohexamer subunit interaction site [polypeptide binding]; other site 460265014856 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 460265014857 active pocket/dimerization site; other site 460265014858 active site 460265014859 phosphorylation site [posttranslational modification] 460265014860 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 460265014861 regulatory protein interface [polypeptide binding]; other site 460265014862 active site 460265014863 regulatory phosphorylation site [posttranslational modification]; other site 460265014864 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 460265014865 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 460265014866 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 460265014867 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 460265014868 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 460265014869 active site 460265014870 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 460265014871 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 460265014872 FAD binding site [chemical binding]; other site 460265014873 substrate binding site [chemical binding]; other site 460265014874 catalytic base [active] 460265014875 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265014876 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 460265014877 substrate binding site [chemical binding]; other site 460265014878 oxyanion hole (OAH) forming residues; other site 460265014879 trimer interface [polypeptide binding]; other site 460265014880 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 460265014881 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 460265014882 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 460265014883 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 460265014884 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 460265014885 dimer interface [polypeptide binding]; other site 460265014886 active site 460265014887 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 460265014888 classical (c) SDRs; Region: SDR_c; cd05233 460265014889 NAD(P) binding site [chemical binding]; other site 460265014890 active site 460265014891 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 460265014892 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265014893 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 460265014894 acyl-activating enzyme (AAE) consensus motif; other site 460265014895 acyl-activating enzyme (AAE) consensus motif; other site 460265014896 putative AMP binding site [chemical binding]; other site 460265014897 putative active site [active] 460265014898 putative CoA binding site [chemical binding]; other site 460265014899 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 460265014900 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 460265014901 putative valine binding site [chemical binding]; other site 460265014902 dimer interface [polypeptide binding]; other site 460265014903 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 460265014904 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 460265014905 putative active site [active] 460265014906 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 460265014907 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 460265014908 PYR/PP interface [polypeptide binding]; other site 460265014909 dimer interface [polypeptide binding]; other site 460265014910 TPP binding site [chemical binding]; other site 460265014911 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 460265014912 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 460265014913 TPP-binding site [chemical binding]; other site 460265014914 dimer interface [polypeptide binding]; other site 460265014915 CheW-like domain; Region: CheW; pfam01584 460265014916 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 460265014917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265014918 S-adenosylmethionine binding site [chemical binding]; other site 460265014919 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 460265014920 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 460265014921 dimerization interface [polypeptide binding]; other site 460265014922 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 460265014923 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 460265014924 dimer interface [polypeptide binding]; other site 460265014925 putative CheW interface [polypeptide binding]; other site 460265014926 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 460265014927 putative binding surface; other site 460265014928 active site 460265014929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265014930 ATP binding site [chemical binding]; other site 460265014931 Mg2+ binding site [ion binding]; other site 460265014932 G-X-G motif; other site 460265014933 Response regulator receiver domain; Region: Response_reg; pfam00072 460265014934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265014935 active site 460265014936 phosphorylation site [posttranslational modification] 460265014937 intermolecular recognition site; other site 460265014938 dimerization interface [polypeptide binding]; other site 460265014939 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 460265014940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265014941 active site 460265014942 phosphorylation site [posttranslational modification] 460265014943 intermolecular recognition site; other site 460265014944 dimerization interface [polypeptide binding]; other site 460265014945 CheB methylesterase; Region: CheB_methylest; pfam01339 460265014946 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 460265014947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265014948 active site 460265014949 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 460265014950 phosphorylation site [posttranslational modification] 460265014951 intermolecular recognition site; other site 460265014952 dimerization interface [polypeptide binding]; other site 460265014953 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265014954 dimer interface [polypeptide binding]; other site 460265014955 phosphorylation site [posttranslational modification] 460265014956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265014957 ATP binding site [chemical binding]; other site 460265014958 Mg2+ binding site [ion binding]; other site 460265014959 G-X-G motif; other site 460265014960 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 460265014961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265014962 active site 460265014963 phosphorylation site [posttranslational modification] 460265014964 intermolecular recognition site; other site 460265014965 dimerization interface [polypeptide binding]; other site 460265014966 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 460265014967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265014968 dimer interface [polypeptide binding]; other site 460265014969 phosphorylation site [posttranslational modification] 460265014970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265014971 ATP binding site [chemical binding]; other site 460265014972 Mg2+ binding site [ion binding]; other site 460265014973 G-X-G motif; other site 460265014974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265014975 Response regulator receiver domain; Region: Response_reg; pfam00072 460265014976 active site 460265014977 phosphorylation site [posttranslational modification] 460265014978 intermolecular recognition site; other site 460265014979 dimerization interface [polypeptide binding]; other site 460265014980 methionine gamma-lyase; Validated; Region: PRK07049 460265014981 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 460265014982 homodimer interface [polypeptide binding]; other site 460265014983 substrate-cofactor binding pocket; other site 460265014984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265014985 catalytic residue [active] 460265014986 Protein of unknown function (DUF563); Region: DUF563; pfam04577 460265014987 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 460265014988 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 460265014989 TrkA-N domain; Region: TrkA_N; pfam02254 460265014990 AAA domain; Region: AAA_30; pfam13604 460265014991 Family description; Region: UvrD_C_2; pfam13538 460265014992 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 460265014993 active site 460265014994 HslU subunit interaction site [polypeptide binding]; other site 460265014995 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 460265014996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265014997 Walker A motif; other site 460265014998 ATP binding site [chemical binding]; other site 460265014999 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 460265015000 Walker B motif; other site 460265015001 arginine finger; other site 460265015002 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 460265015003 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 460265015004 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 460265015005 Mg++ binding site [ion binding]; other site 460265015006 putative catalytic motif [active] 460265015007 putative substrate binding site [chemical binding]; other site 460265015008 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 460265015009 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 460265015010 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 460265015011 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 460265015012 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 460265015013 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 460265015014 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 460265015015 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 460265015016 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 460265015017 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 460265015018 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 460265015019 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 460265015020 MraW methylase family; Region: Methyltransf_5; cl17771 460265015021 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 460265015022 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 460265015023 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 460265015024 dimer interface [polypeptide binding]; other site 460265015025 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265015026 active site 460265015027 metal binding site [ion binding]; metal-binding site 460265015028 glutathione binding site [chemical binding]; other site 460265015029 aminopeptidase N; Provisional; Region: pepN; PRK14015 460265015030 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 460265015031 active site 460265015032 Zn binding site [ion binding]; other site 460265015033 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265015034 PAS fold; Region: PAS_3; pfam08447 460265015035 putative active site [active] 460265015036 heme pocket [chemical binding]; other site 460265015037 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 460265015038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265015039 dimer interface [polypeptide binding]; other site 460265015040 phosphorylation site [posttranslational modification] 460265015041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265015042 ATP binding site [chemical binding]; other site 460265015043 Mg2+ binding site [ion binding]; other site 460265015044 G-X-G motif; other site 460265015045 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 460265015046 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 460265015047 metal binding triad; other site 460265015048 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 460265015049 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 460265015050 metal binding triad; other site 460265015051 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 460265015052 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 460265015053 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 460265015054 putative DNA binding site [nucleotide binding]; other site 460265015055 putative Zn2+ binding site [ion binding]; other site 460265015056 AsnC family; Region: AsnC_trans_reg; pfam01037 460265015057 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 460265015058 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 460265015059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265015060 catalytic residue [active] 460265015061 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265015062 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 460265015063 dimerization interface [polypeptide binding]; other site 460265015064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265015065 dimer interface [polypeptide binding]; other site 460265015066 phosphorylation site [posttranslational modification] 460265015067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265015068 ATP binding site [chemical binding]; other site 460265015069 Mg2+ binding site [ion binding]; other site 460265015070 G-X-G motif; other site 460265015071 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 460265015072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265015073 active site 460265015074 phosphorylation site [posttranslational modification] 460265015075 intermolecular recognition site; other site 460265015076 dimerization interface [polypeptide binding]; other site 460265015077 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265015078 DNA binding site [nucleotide binding] 460265015079 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265015080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265015081 ABC transporter signature motif; other site 460265015082 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 460265015083 GSCFA family; Region: GSCFA; pfam08885 460265015084 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 460265015085 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 460265015086 ligand binding site [chemical binding]; other site 460265015087 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 460265015088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 460265015089 binding surface 460265015090 TPR motif; other site 460265015091 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 460265015092 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 460265015093 FtsH Extracellular; Region: FtsH_ext; pfam06480 460265015094 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 460265015095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265015096 Walker A motif; other site 460265015097 ATP binding site [chemical binding]; other site 460265015098 Walker B motif; other site 460265015099 arginine finger; other site 460265015100 Peptidase family M41; Region: Peptidase_M41; pfam01434 460265015101 septum formation inhibitor; Reviewed; Region: minC; PRK05177 460265015102 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 460265015103 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 460265015104 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 460265015105 Switch I; other site 460265015106 Switch II; other site 460265015107 Septum formation topological specificity factor MinE; Region: MinE; cl00538 460265015108 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265015109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265015110 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_5; cd08426 460265015111 putative dimerization interface [polypeptide binding]; other site 460265015112 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 460265015113 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 460265015114 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 460265015115 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 460265015116 NAD(P) binding site [chemical binding]; other site 460265015117 catalytic residues [active] 460265015118 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 460265015119 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 460265015120 Nucleoside recognition; Region: Gate; pfam07670 460265015121 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 460265015122 Caspase domain; Region: Peptidase_C14; pfam00656 460265015123 recombinase A; Provisional; Region: recA; PRK09354 460265015124 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 460265015125 hexamer interface [polypeptide binding]; other site 460265015126 Walker A motif; other site 460265015127 ATP binding site [chemical binding]; other site 460265015128 Walker B motif; other site 460265015129 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 460265015130 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 460265015131 motif 1; other site 460265015132 active site 460265015133 motif 2; other site 460265015134 motif 3; other site 460265015135 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 460265015136 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 460265015137 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 460265015138 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 460265015139 NAD binding site [chemical binding]; other site 460265015140 substrate binding site [chemical binding]; other site 460265015141 homodimer interface [polypeptide binding]; other site 460265015142 active site 460265015143 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 460265015144 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 460265015145 NADP binding site [chemical binding]; other site 460265015146 active site 460265015147 putative substrate binding site [chemical binding]; other site 460265015148 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 460265015149 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 460265015150 substrate binding site; other site 460265015151 tetramer interface; other site 460265015152 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 460265015153 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 460265015154 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 460265015155 phosphodiesterase YaeI; Provisional; Region: PRK11340 460265015156 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 460265015157 putative active site [active] 460265015158 putative metal binding site [ion binding]; other site 460265015159 aminotransferase; Provisional; Region: PRK06105 460265015160 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 460265015161 inhibitor-cofactor binding pocket; inhibition site 460265015162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265015163 catalytic residue [active] 460265015164 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 460265015165 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 460265015166 Walker A/P-loop; other site 460265015167 ATP binding site [chemical binding]; other site 460265015168 Q-loop/lid; other site 460265015169 ABC transporter signature motif; other site 460265015170 Walker B; other site 460265015171 D-loop; other site 460265015172 H-loop/switch region; other site 460265015173 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 460265015174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265015175 dimer interface [polypeptide binding]; other site 460265015176 conserved gate region; other site 460265015177 putative PBP binding loops; other site 460265015178 ABC-ATPase subunit interface; other site 460265015179 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 460265015180 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 460265015181 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 460265015182 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 460265015183 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 460265015184 metal ion-dependent adhesion site (MIDAS); other site 460265015185 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265015186 non-specific DNA binding site [nucleotide binding]; other site 460265015187 salt bridge; other site 460265015188 sequence-specific DNA binding site [nucleotide binding]; other site 460265015189 Flagellar protein FlbT; Region: FlbT; cl11455 460265015190 enoyl-CoA hydratase; Provisional; Region: PRK08140 460265015191 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265015192 substrate binding site [chemical binding]; other site 460265015193 oxyanion hole (OAH) forming residues; other site 460265015194 trimer interface [polypeptide binding]; other site 460265015195 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 460265015196 CoenzymeA binding site [chemical binding]; other site 460265015197 subunit interaction site [polypeptide binding]; other site 460265015198 PHB binding site; other site 460265015199 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265015200 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 460265015201 acyl-activating enzyme (AAE) consensus motif; other site 460265015202 AMP binding site [chemical binding]; other site 460265015203 active site 460265015204 CoA binding site [chemical binding]; other site 460265015205 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265015206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265015207 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 460265015208 dimerization interface [polypeptide binding]; other site 460265015209 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 460265015210 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 460265015211 metal binding site [ion binding]; metal-binding site 460265015212 active site 460265015213 I-site; other site 460265015214 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 460265015215 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 460265015216 MarR family; Region: MarR; pfam01047 460265015217 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 460265015218 PAS domain; Region: PAS_8; pfam13188 460265015219 PAS fold; Region: PAS_4; pfam08448 460265015220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265015221 dimer interface [polypeptide binding]; other site 460265015222 phosphorylation site [posttranslational modification] 460265015223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265015224 ATP binding site [chemical binding]; other site 460265015225 Mg2+ binding site [ion binding]; other site 460265015226 G-X-G motif; other site 460265015227 Response regulator receiver domain; Region: Response_reg; pfam00072 460265015228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265015229 active site 460265015230 phosphorylation site [posttranslational modification] 460265015231 intermolecular recognition site; other site 460265015232 dimerization interface [polypeptide binding]; other site 460265015233 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 460265015234 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 460265015235 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 460265015236 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 460265015237 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00732 460265015238 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 460265015239 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 460265015240 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 460265015241 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 460265015242 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 460265015243 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 460265015244 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 460265015245 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 460265015246 polyphosphate kinase; Provisional; Region: PRK05443 460265015247 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 460265015248 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 460265015249 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 460265015250 putative domain interface [polypeptide binding]; other site 460265015251 putative active site [active] 460265015252 catalytic site [active] 460265015253 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 460265015254 putative domain interface [polypeptide binding]; other site 460265015255 putative active site [active] 460265015256 catalytic site [active] 460265015257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265015258 AAA domain; Region: AAA_22; pfam13401 460265015259 Walker A motif; other site 460265015260 ATP binding site [chemical binding]; other site 460265015261 Walker B motif; other site 460265015262 arginine finger; other site 460265015263 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 460265015264 Domain of unknown function DUF20; Region: UPF0118; pfam01594 460265015265 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 460265015266 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 460265015267 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 460265015268 dimerization interface [polypeptide binding]; other site 460265015269 putative ATP binding site [chemical binding]; other site 460265015270 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 460265015271 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 460265015272 active site 460265015273 substrate binding site [chemical binding]; other site 460265015274 cosubstrate binding site; other site 460265015275 catalytic site [active] 460265015276 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 460265015277 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 460265015278 SEC-C motif; Region: SEC-C; pfam02810 460265015279 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 460265015280 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 460265015281 putative tRNA-binding site [nucleotide binding]; other site 460265015282 B3/4 domain; Region: B3_4; pfam03483 460265015283 tRNA synthetase B5 domain; Region: B5; smart00874 460265015284 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 460265015285 dimer interface [polypeptide binding]; other site 460265015286 motif 1; other site 460265015287 motif 3; other site 460265015288 motif 2; other site 460265015289 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 460265015290 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 460265015291 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 460265015292 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 460265015293 dimer interface [polypeptide binding]; other site 460265015294 motif 1; other site 460265015295 active site 460265015296 motif 2; other site 460265015297 motif 3; other site 460265015298 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 460265015299 23S rRNA binding site [nucleotide binding]; other site 460265015300 L21 binding site [polypeptide binding]; other site 460265015301 L13 binding site [polypeptide binding]; other site 460265015302 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 460265015303 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 460265015304 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265015305 putative ADP-binding pocket [chemical binding]; other site 460265015306 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 460265015307 Protein of unknown function, DUF608; Region: DUF608; pfam04685 460265015308 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 460265015309 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 460265015310 homodimer interaction site [polypeptide binding]; other site 460265015311 cofactor binding site; other site 460265015312 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 460265015313 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 460265015314 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 460265015315 oxyanion hole [active] 460265015316 OpgC protein; Region: OpgC_C; pfam10129 460265015317 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 460265015318 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 460265015319 DNA polymerase III subunit chi; Validated; Region: PRK05728 460265015320 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 460265015321 Protein of unknown function (DUF1190); Region: DUF1190; pfam06693 460265015322 Predicted membrane protein [Function unknown]; Region: COG3766 460265015323 CTP synthetase; Validated; Region: pyrG; PRK05380 460265015324 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 460265015325 Catalytic site [active] 460265015326 active site 460265015327 UTP binding site [chemical binding]; other site 460265015328 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 460265015329 active site 460265015330 putative oxyanion hole; other site 460265015331 catalytic triad [active] 460265015332 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 460265015333 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 460265015334 triosephosphate isomerase; Provisional; Region: PRK14565 460265015335 substrate binding site [chemical binding]; other site 460265015336 dimer interface [polypeptide binding]; other site 460265015337 catalytic triad [active] 460265015338 periplasmic folding chaperone; Provisional; Region: PRK10788 460265015339 SurA N-terminal domain; Region: SurA_N_3; cl07813 460265015340 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 460265015341 anthranilate synthase component I; Provisional; Region: PRK13573 460265015342 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 460265015343 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 460265015344 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 460265015345 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 460265015346 glutamine binding [chemical binding]; other site 460265015347 catalytic triad [active] 460265015348 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 460265015349 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 460265015350 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 460265015351 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 460265015352 active site 460265015353 ribulose/triose binding site [chemical binding]; other site 460265015354 phosphate binding site [ion binding]; other site 460265015355 substrate (anthranilate) binding pocket [chemical binding]; other site 460265015356 product (indole) binding pocket [chemical binding]; other site 460265015357 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 460265015358 trimer interface [polypeptide binding]; other site 460265015359 dimer interface [polypeptide binding]; other site 460265015360 putative active site [active] 460265015361 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 460265015362 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 460265015363 dimer interface [polypeptide binding]; other site 460265015364 putative functional site; other site 460265015365 putative MPT binding site; other site 460265015366 RNA polymerase sigma factor; Provisional; Region: PRK12547 460265015367 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265015368 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 460265015369 DNA binding residues [nucleotide binding] 460265015370 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265015371 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 460265015372 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 460265015373 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265015374 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 460265015375 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 460265015376 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 460265015377 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 460265015378 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 460265015379 metal binding site 2 [ion binding]; metal-binding site 460265015380 putative DNA binding helix; other site 460265015381 metal binding site 1 [ion binding]; metal-binding site 460265015382 dimer interface [polypeptide binding]; other site 460265015383 structural Zn2+ binding site [ion binding]; other site 460265015384 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 460265015385 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 460265015386 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 460265015387 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 460265015388 Right handed beta helix region; Region: Beta_helix; pfam13229 460265015389 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 460265015390 GtrA-like protein; Region: GtrA; pfam04138 460265015391 O-Antigen ligase; Region: Wzy_C; pfam04932 460265015392 hypothetical protein; Validated; Region: PRK08238 460265015393 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 460265015394 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 460265015395 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265015396 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 460265015397 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 460265015398 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265015399 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265015400 DNA binding residues [nucleotide binding] 460265015401 dimerization interface [polypeptide binding]; other site 460265015402 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 460265015403 Chain length determinant protein; Region: Wzz; pfam02706 460265015404 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 460265015405 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 460265015406 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 460265015407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265015408 NAD(P) binding site [chemical binding]; other site 460265015409 active site 460265015410 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 460265015411 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 460265015412 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 460265015413 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 460265015414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265015415 NAD(P) binding site [chemical binding]; other site 460265015416 active site 460265015417 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 460265015418 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265015419 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 460265015420 Arabidopsis thaliana GDP-mannose-3',5'-epimerase (GME)-like, extended (e) SDRs; Region: GME-like_SDR_e; cd05273 460265015421 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 460265015422 NAD binding site [chemical binding]; other site 460265015423 homodimer interface [polypeptide binding]; other site 460265015424 substrate binding site [chemical binding]; other site 460265015425 active site 460265015426 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 460265015427 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265015428 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265015429 ligand binding site [chemical binding]; other site 460265015430 flexible hinge region; other site 460265015431 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 460265015432 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265015433 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 460265015434 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 460265015435 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 460265015436 Substrate binding site; other site 460265015437 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 460265015438 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 460265015439 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 460265015440 SLBB domain; Region: SLBB; pfam10531 460265015441 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 460265015442 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 460265015443 NAD binding site [chemical binding]; other site 460265015444 putative substrate binding site 2 [chemical binding]; other site 460265015445 putative substrate binding site 1 [chemical binding]; other site 460265015446 active site 460265015447 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 460265015448 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 460265015449 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 460265015450 Bacterial sugar transferase; Region: Bac_transf; pfam02397 460265015451 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265015452 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265015453 DNA binding residues [nucleotide binding] 460265015454 dimerization interface [polypeptide binding]; other site 460265015455 Domain of unknown function (DUF305); Region: DUF305; cl17794 460265015456 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 460265015457 Protein export membrane protein; Region: SecD_SecF; cl14618 460265015458 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 460265015459 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 460265015460 Winged helix-turn helix; Region: HTH_29; pfam13551 460265015461 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265015462 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 460265015463 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265015464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 460265015465 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 460265015466 Domain of unknown function DUF21; Region: DUF21; pfam01595 460265015467 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 460265015468 Transporter associated domain; Region: CorC_HlyC; smart01091 460265015469 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 460265015470 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265015471 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265015472 Domain of unknown function (DUF4313); Region: DUF4313; pfam14190 460265015473 TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes:...; Region: TBP_TLF; cl08263 460265015474 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 460265015475 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 460265015476 PRC-barrel domain; Region: PRC; pfam05239 460265015477 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 460265015478 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 460265015479 tetramerization interface [polypeptide binding]; other site 460265015480 active site 460265015481 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 460265015482 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 460265015483 inhibitor site; inhibition site 460265015484 active site 460265015485 dimer interface [polypeptide binding]; other site 460265015486 catalytic residue [active] 460265015487 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 460265015488 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 460265015489 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 460265015490 putative DNA binding site [nucleotide binding]; other site 460265015491 putative Zn2+ binding site [ion binding]; other site 460265015492 AsnC family; Region: AsnC_trans_reg; pfam01037 460265015493 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 460265015494 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 460265015495 catalytic residue [active] 460265015496 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 460265015497 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 460265015498 putative active site [active] 460265015499 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 460265015500 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 460265015501 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 460265015502 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 460265015503 PYR/PP interface [polypeptide binding]; other site 460265015504 dimer interface [polypeptide binding]; other site 460265015505 TPP binding site [chemical binding]; other site 460265015506 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 460265015507 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 460265015508 TPP-binding site [chemical binding]; other site 460265015509 dimer interface [polypeptide binding]; other site 460265015510 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 460265015511 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 460265015512 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 460265015513 shikimate binding site; other site 460265015514 NAD(P) binding site [chemical binding]; other site 460265015515 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 460265015516 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 460265015517 dimer interface [polypeptide binding]; other site 460265015518 active site 460265015519 metal binding site [ion binding]; metal-binding site 460265015520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265015521 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 460265015522 NAD(P) binding site [chemical binding]; other site 460265015523 active site 460265015524 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 460265015525 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 460265015526 metal binding site [ion binding]; metal-binding site 460265015527 substrate binding pocket [chemical binding]; other site 460265015528 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265015529 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 460265015530 active site 460265015531 metal binding site [ion binding]; metal-binding site 460265015532 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265015533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265015534 DNA-binding site [nucleotide binding]; DNA binding site 460265015535 FCD domain; Region: FCD; pfam07729 460265015536 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 460265015537 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 460265015538 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 460265015539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265015540 dimer interface [polypeptide binding]; other site 460265015541 conserved gate region; other site 460265015542 putative PBP binding loops; other site 460265015543 ABC-ATPase subunit interface; other site 460265015544 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 460265015545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265015546 dimer interface [polypeptide binding]; other site 460265015547 conserved gate region; other site 460265015548 putative PBP binding loops; other site 460265015549 ABC-ATPase subunit interface; other site 460265015550 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 460265015551 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 460265015552 Walker A/P-loop; other site 460265015553 ATP binding site [chemical binding]; other site 460265015554 Q-loop/lid; other site 460265015555 ABC transporter signature motif; other site 460265015556 Walker B; other site 460265015557 D-loop; other site 460265015558 H-loop/switch region; other site 460265015559 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 460265015560 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 460265015561 putative NAD(P) binding site [chemical binding]; other site 460265015562 catalytic Zn binding site [ion binding]; other site 460265015563 PRC-barrel domain; Region: PRC; pfam05239 460265015564 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 460265015565 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 460265015566 heme-binding site [chemical binding]; other site 460265015567 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 460265015568 FAD binding pocket [chemical binding]; other site 460265015569 FAD binding motif [chemical binding]; other site 460265015570 phosphate binding motif [ion binding]; other site 460265015571 beta-alpha-beta structure motif; other site 460265015572 NAD binding pocket [chemical binding]; other site 460265015573 Heme binding pocket [chemical binding]; other site 460265015574 PRC-barrel domain; Region: PRC; pfam05239 460265015575 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 460265015576 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 460265015577 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 460265015578 dimerization interface [polypeptide binding]; other site 460265015579 putative DNA binding site [nucleotide binding]; other site 460265015580 putative Zn2+ binding site [ion binding]; other site 460265015581 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 460265015582 Low molecular weight phosphatase family; Region: LMWPc; cd00115 460265015583 active site 460265015584 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 460265015585 ArsC family; Region: ArsC; pfam03960 460265015586 catalytic residues [active] 460265015587 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 460265015588 amphipathic channel; other site 460265015589 Asn-Pro-Ala signature motifs; other site 460265015590 Methyltransferase domain; Region: Methyltransf_31; pfam13847 460265015591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265015592 S-adenosylmethionine binding site [chemical binding]; other site 460265015593 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 460265015594 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 460265015595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265015596 non-specific DNA binding site [nucleotide binding]; other site 460265015597 salt bridge; other site 460265015598 sequence-specific DNA binding site [nucleotide binding]; other site 460265015599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265015600 active site 460265015601 phosphorylation site [posttranslational modification] 460265015602 intermolecular recognition site; other site 460265015603 dimerization interface [polypeptide binding]; other site 460265015604 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 460265015605 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 460265015606 CHRD domain; Region: CHRD; pfam07452 460265015607 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 460265015608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265015609 S-adenosylmethionine binding site [chemical binding]; other site 460265015610 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 460265015611 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 460265015612 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 460265015613 dimerization interface [polypeptide binding]; other site 460265015614 putative DNA binding site [nucleotide binding]; other site 460265015615 putative Zn2+ binding site [ion binding]; other site 460265015616 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 460265015617 Low molecular weight phosphatase family; Region: LMWPc; cd00115 460265015618 active site 460265015619 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 460265015620 ArsC family; Region: ArsC; pfam03960 460265015621 catalytic residues [active] 460265015622 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 460265015623 amphipathic channel; other site 460265015624 Asn-Pro-Ala signature motifs; other site 460265015625 Methyltransferase domain; Region: Methyltransf_31; pfam13847 460265015626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265015627 S-adenosylmethionine binding site [chemical binding]; other site 460265015628 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 460265015629 putative active site [active] 460265015630 putative metal binding residues [ion binding]; other site 460265015631 signature motif; other site 460265015632 putative dimer interface [polypeptide binding]; other site 460265015633 putative phosphate binding site [ion binding]; other site 460265015634 FOG: CBS domain [General function prediction only]; Region: COG0517 460265015635 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 460265015636 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 460265015637 metal-binding site [ion binding] 460265015638 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 460265015639 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 460265015640 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 460265015641 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 460265015642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 460265015643 motif II; other site 460265015644 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 460265015645 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 460265015646 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 460265015647 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 460265015648 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 460265015649 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 460265015650 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 460265015651 metal binding site [ion binding]; metal-binding site 460265015652 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 460265015653 metal binding site 2 [ion binding]; metal-binding site 460265015654 putative DNA binding helix; other site 460265015655 metal binding site 1 [ion binding]; metal-binding site 460265015656 dimer interface [polypeptide binding]; other site 460265015657 structural Zn2+ binding site [ion binding]; other site 460265015658 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 460265015659 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 460265015660 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 460265015661 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 460265015662 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 460265015663 Phage-related protein, tail component [Function unknown]; Region: COG4733 460265015664 Putative phage tail protein; Region: Phage-tail_3; pfam13550 460265015665 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 460265015666 Interdomain contacts; other site 460265015667 Cytokine receptor motif; other site 460265015668 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 460265015669 Phage-related protein, tail component [Function unknown]; Region: COG4723 460265015670 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 460265015671 Phage minor tail protein L; Region: Phage_tail_L; cl01908 460265015672 Phage minor tail protein; Region: Phage_min_tail; cl01940 460265015673 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 460265015674 Phage-related minor tail protein [Function unknown]; Region: COG5281 460265015675 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265015676 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265015677 catalytic residue [active] 460265015678 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 460265015679 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 460265015680 active site clefts [active] 460265015681 zinc binding site [ion binding]; other site 460265015682 dimer interface [polypeptide binding]; other site 460265015683 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 460265015684 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 460265015685 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 460265015686 oligomer interface [polypeptide binding]; other site 460265015687 active site residues [active] 460265015688 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 460265015689 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 460265015690 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 460265015691 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP); Region: NGN_SP; cd09886 460265015692 D5 N terminal like; Region: D5_N; smart00885 460265015693 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 460265015694 VRR-NUC domain; Region: VRR_NUC; pfam08774 460265015695 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265015696 non-specific DNA binding site [nucleotide binding]; other site 460265015697 salt bridge; other site 460265015698 Predicted transcriptional regulator [Transcription]; Region: COG2932 460265015699 sequence-specific DNA binding site [nucleotide binding]; other site 460265015700 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 460265015701 Catalytic site [active] 460265015702 GcrA cell cycle regulator; Region: GcrA; cl11564 460265015703 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 460265015704 Domain of unknown function (DUF329); Region: DUF329; cl01144 460265015705 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 460265015706 active site 460265015707 catalytic residues [active] 460265015708 DNA binding site [nucleotide binding] 460265015709 Int/Topo IB signature motif; other site 460265015710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265015711 S-adenosylmethionine binding site [chemical binding]; other site 460265015712 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 460265015713 dimer interface [polypeptide binding]; other site 460265015714 substrate binding site [chemical binding]; other site 460265015715 metal binding sites [ion binding]; metal-binding site 460265015716 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 460265015717 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 460265015718 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 460265015719 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 460265015720 Cl- selectivity filter; other site 460265015721 Cl- binding residues [ion binding]; other site 460265015722 pore gating glutamate residue; other site 460265015723 dimer interface [polypeptide binding]; other site 460265015724 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 460265015725 tartrate dehydrogenase; Region: TTC; TIGR02089 460265015726 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 460265015727 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 460265015728 RNA/DNA hybrid binding site [nucleotide binding]; other site 460265015729 active site 460265015730 urate oxidase; Region: urate_oxi; TIGR03383 460265015731 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 460265015732 active site 460265015733 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 460265015734 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 460265015735 active site 460265015736 homotetramer interface [polypeptide binding]; other site 460265015737 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265015738 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 460265015739 active site 460265015740 dimer interface [polypeptide binding]; other site 460265015741 metal binding site [ion binding]; metal-binding site 460265015742 glutathione binding site [chemical binding]; other site 460265015743 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 460265015744 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 460265015745 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 460265015746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265015747 homodimer interface [polypeptide binding]; other site 460265015748 catalytic residue [active] 460265015749 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 460265015750 prephenate dehydrogenase; Validated; Region: PRK08507 460265015751 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 460265015752 nucleophile elbow; other site 460265015753 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 460265015754 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 460265015755 dimer interface [polypeptide binding]; other site 460265015756 TPP-binding site [chemical binding]; other site 460265015757 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 460265015758 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 460265015759 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 460265015760 E3 interaction surface; other site 460265015761 lipoyl attachment site [posttranslational modification]; other site 460265015762 e3 binding domain; Region: E3_binding; pfam02817 460265015763 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 460265015764 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 460265015765 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 460265015766 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 460265015767 Peptidase family M23; Region: Peptidase_M23; pfam01551 460265015768 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 460265015769 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 460265015770 putative DNA binding site [nucleotide binding]; other site 460265015771 putative Zn2+ binding site [ion binding]; other site 460265015772 AsnC family; Region: AsnC_trans_reg; pfam01037 460265015773 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 460265015774 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 460265015775 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 460265015776 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 460265015777 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 460265015778 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265015779 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265015780 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 460265015781 putative effector binding pocket; other site 460265015782 dimerization interface [polypeptide binding]; other site 460265015783 TMAO/DMSO reductase; Reviewed; Region: PRK05363 460265015784 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 460265015785 Moco binding site; other site 460265015786 metal coordination site [ion binding]; other site 460265015787 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265015788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265015789 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265015790 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 460265015791 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 460265015792 acyl-activating enzyme (AAE) consensus motif; other site 460265015793 putative AMP binding site [chemical binding]; other site 460265015794 putative active site [active] 460265015795 putative CoA binding site [chemical binding]; other site 460265015796 multifunctional aminopeptidase A; Provisional; Region: PRK00913 460265015797 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 460265015798 interface (dimer of trimers) [polypeptide binding]; other site 460265015799 Substrate-binding/catalytic site; other site 460265015800 Zn-binding sites [ion binding]; other site 460265015801 Predicted permeases [General function prediction only]; Region: COG0795 460265015802 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 460265015803 Predicted permeases [General function prediction only]; Region: COG0795 460265015804 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 460265015805 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 460265015806 Organic solvent tolerance protein; Region: OstA_C; pfam04453 460265015807 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 460265015808 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 460265015809 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 460265015810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265015811 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 460265015812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 460265015813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265015814 dimer interface [polypeptide binding]; other site 460265015815 phosphorylation site [posttranslational modification] 460265015816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265015817 ATP binding site [chemical binding]; other site 460265015818 Mg2+ binding site [ion binding]; other site 460265015819 G-X-G motif; other site 460265015820 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 460265015821 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 460265015822 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 460265015823 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 460265015824 catalytic residue [active] 460265015825 FeS assembly protein SufD; Region: sufD; TIGR01981 460265015826 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 460265015827 FeS assembly ATPase SufC; Region: sufC; TIGR01978 460265015828 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 460265015829 Walker A/P-loop; other site 460265015830 ATP binding site [chemical binding]; other site 460265015831 Q-loop/lid; other site 460265015832 ABC transporter signature motif; other site 460265015833 Walker B; other site 460265015834 D-loop; other site 460265015835 H-loop/switch region; other site 460265015836 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 460265015837 putative ABC transporter; Region: ycf24; CHL00085 460265015838 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 460265015839 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 460265015840 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 460265015841 catalytic residue [active] 460265015842 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 460265015843 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 460265015844 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 460265015845 acyl-activating enzyme (AAE) consensus motif; other site 460265015846 AMP binding site [chemical binding]; other site 460265015847 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 460265015848 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 460265015849 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 460265015850 putative trimer interface [polypeptide binding]; other site 460265015851 putative CoA binding site [chemical binding]; other site 460265015852 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 460265015853 catalytic core [active] 460265015854 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 460265015855 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 460265015856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265015857 Mg2+ binding site [ion binding]; other site 460265015858 G-X-G motif; other site 460265015859 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 460265015860 anchoring element; other site 460265015861 dimer interface [polypeptide binding]; other site 460265015862 ATP binding site [chemical binding]; other site 460265015863 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 460265015864 active site 460265015865 putative metal-binding site [ion binding]; other site 460265015866 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 460265015867 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 460265015868 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 460265015869 active site 460265015870 catalytic tetrad [active] 460265015871 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 460265015872 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 460265015873 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 460265015874 Transglycosylase; Region: Transgly; pfam00912 460265015875 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 460265015876 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 460265015877 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 460265015878 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 460265015879 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 460265015880 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 460265015881 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 460265015882 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 460265015883 putative active site [active] 460265015884 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 460265015885 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 460265015886 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 460265015887 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 460265015888 dimer interface [polypeptide binding]; other site 460265015889 active site 460265015890 glycine-pyridoxal phosphate binding site [chemical binding]; other site 460265015891 folate binding site [chemical binding]; other site 460265015892 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 460265015893 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 460265015894 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 460265015895 ParB-like nuclease domain; Region: ParB; smart00470 460265015896 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 460265015897 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 460265015898 P-loop; other site 460265015899 Magnesium ion binding site [ion binding]; other site 460265015900 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 460265015901 Magnesium ion binding site [ion binding]; other site 460265015902 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 460265015903 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 460265015904 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 460265015905 trimer interface [polypeptide binding]; other site 460265015906 active site 460265015907 substrate binding site [chemical binding]; other site 460265015908 CoA binding site [chemical binding]; other site 460265015909 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 460265015910 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 460265015911 Ligand binding site; other site 460265015912 metal-binding site 460265015913 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 460265015914 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 460265015915 SLBB domain; Region: SLBB; pfam10531 460265015916 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 460265015917 poly(beta-D-mannuronate) lyase; Provisional; Region: algL; PRK00325 460265015918 active site 460265015919 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 460265015920 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 460265015921 active site 460265015922 metal binding site [ion binding]; metal-binding site 460265015923 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265015924 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 460265015925 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 460265015926 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 460265015927 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 460265015928 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 460265015929 Bacterial sugar transferase; Region: Bac_transf; pfam02397 460265015930 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 460265015931 Chain length determinant protein; Region: Wzz; cl15801 460265015932 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 460265015933 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 460265015934 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 460265015935 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 460265015936 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 460265015937 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265015938 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 460265015939 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 460265015940 active site 460265015941 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 460265015942 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265015943 active site 460265015944 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 460265015945 trimer interface [polypeptide binding]; other site 460265015946 active site 460265015947 substrate binding site [chemical binding]; other site 460265015948 CoA binding site [chemical binding]; other site 460265015949 DoxX-like family; Region: DoxX_2; pfam13564 460265015950 PilZ domain; Region: PilZ; pfam07238 460265015951 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 460265015952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 460265015953 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 460265015954 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 460265015955 Coenzyme A binding pocket [chemical binding]; other site 460265015956 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 460265015957 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 460265015958 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 460265015959 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 460265015960 Ligand binding site; other site 460265015961 Putative Catalytic site; other site 460265015962 DXD motif; other site 460265015963 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 460265015964 putative active site [active] 460265015965 YdjC motif; other site 460265015966 Mg binding site [ion binding]; other site 460265015967 putative homodimer interface [polypeptide binding]; other site 460265015968 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 460265015969 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 460265015970 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 460265015971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265015972 PAS fold; Region: PAS_3; pfam08447 460265015973 putative active site [active] 460265015974 heme pocket [chemical binding]; other site 460265015975 PAS fold; Region: PAS_3; pfam08447 460265015976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 460265015977 HWE histidine kinase; Region: HWE_HK; pfam07536 460265015978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265015979 S-adenosylmethionine binding site [chemical binding]; other site 460265015980 S-adenosylmethionine synthetase; Validated; Region: PRK05250 460265015981 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 460265015982 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 460265015983 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 460265015984 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 460265015985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265015986 non-specific DNA binding site [nucleotide binding]; other site 460265015987 salt bridge; other site 460265015988 sequence-specific DNA binding site [nucleotide binding]; other site 460265015989 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 460265015990 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 460265015991 Peptidase family M48; Region: Peptidase_M48; pfam01435 460265015992 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 460265015993 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 460265015994 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 460265015995 FAD binding pocket [chemical binding]; other site 460265015996 FAD binding motif [chemical binding]; other site 460265015997 phosphate binding motif [ion binding]; other site 460265015998 beta-alpha-beta structure motif; other site 460265015999 NAD binding pocket [chemical binding]; other site 460265016000 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 460265016001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265016002 NAD(P) binding site [chemical binding]; other site 460265016003 active site 460265016004 putative acyltransferase; Provisional; Region: PRK05790 460265016005 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 460265016006 dimer interface [polypeptide binding]; other site 460265016007 active site 460265016008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 460265016009 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 460265016010 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 460265016011 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 460265016012 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 460265016013 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 460265016014 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 460265016015 catalytic site [active] 460265016016 putative active site [active] 460265016017 putative substrate binding site [chemical binding]; other site 460265016018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 460265016019 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 460265016020 OstA-like protein; Region: OstA; pfam03968 460265016021 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 460265016022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265016023 S-adenosylmethionine binding site [chemical binding]; other site 460265016024 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 460265016025 RNA polymerase sigma factor; Provisional; Region: PRK12547 460265016026 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265016027 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 460265016028 DNA binding residues [nucleotide binding] 460265016029 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 460265016030 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 460265016031 putative active site [active] 460265016032 putative dimer interface [polypeptide binding]; other site 460265016033 Phasin protein; Region: Phasin_2; cl11491 460265016034 Phasin protein; Region: Phasin_2; cl11491 460265016035 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 460265016036 elongation factor G; Reviewed; Region: PRK12740 460265016037 G1 box; other site 460265016038 putative GEF interaction site [polypeptide binding]; other site 460265016039 GTP/Mg2+ binding site [chemical binding]; other site 460265016040 Switch I region; other site 460265016041 G2 box; other site 460265016042 G3 box; other site 460265016043 Switch II region; other site 460265016044 G4 box; other site 460265016045 G5 box; other site 460265016046 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 460265016047 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 460265016048 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 460265016049 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 460265016050 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 460265016051 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 460265016052 DctM-like transporters; Region: DctM; pfam06808 460265016053 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 460265016054 Predicted flavoprotein [General function prediction only]; Region: COG0431 460265016055 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 460265016056 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 460265016057 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 460265016058 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 460265016059 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265016060 active site 460265016061 Response regulator receiver domain; Region: Response_reg; pfam00072 460265016062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265016063 active site 460265016064 phosphorylation site [posttranslational modification] 460265016065 intermolecular recognition site; other site 460265016066 dimerization interface [polypeptide binding]; other site 460265016067 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 460265016068 GSH binding site [chemical binding]; other site 460265016069 catalytic residues [active] 460265016070 nitrilase; Region: PLN02798 460265016071 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 460265016072 putative active site [active] 460265016073 catalytic triad [active] 460265016074 dimer interface [polypeptide binding]; other site 460265016075 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 460265016076 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 460265016077 Predicted membrane protein [Function unknown]; Region: COG1238 460265016078 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 460265016079 heme-binding site [chemical binding]; other site 460265016080 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 460265016081 dimer interface [polypeptide binding]; other site 460265016082 putative CheW interface [polypeptide binding]; other site 460265016083 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 460265016084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265016085 binding surface 460265016086 TPR motif; other site 460265016087 TPR repeat; Region: TPR_11; pfam13414 460265016088 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 460265016089 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 460265016090 pyruvate kinase; Provisional; Region: PRK06247 460265016091 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 460265016092 domain interfaces; other site 460265016093 active site 460265016094 Protein of unknown function (DUF1036); Region: DUF1036; pfam06282 460265016095 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 460265016096 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 460265016097 MOFRL family; Region: MOFRL; pfam05161 460265016098 N-formylglutamate amidohydrolase; Region: FGase; cl01522 460265016099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 460265016100 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 460265016101 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 460265016102 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 460265016103 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 460265016104 dimer interaction site [polypeptide binding]; other site 460265016105 substrate-binding tunnel; other site 460265016106 active site 460265016107 catalytic site [active] 460265016108 substrate binding site [chemical binding]; other site 460265016109 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 460265016110 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 460265016111 active site 460265016112 metal binding site [ion binding]; metal-binding site 460265016113 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 460265016114 aromatic arch; other site 460265016115 DCoH dimer interaction site [polypeptide binding]; other site 460265016116 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 460265016117 DCoH tetramer interaction site [polypeptide binding]; other site 460265016118 substrate binding site [chemical binding]; other site 460265016119 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 460265016120 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 460265016121 membrane-bound complex binding site; other site 460265016122 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 460265016123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265016124 dimer interface [polypeptide binding]; other site 460265016125 conserved gate region; other site 460265016126 putative PBP binding loops; other site 460265016127 ABC-ATPase subunit interface; other site 460265016128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265016129 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 460265016130 Walker A/P-loop; other site 460265016131 ATP binding site [chemical binding]; other site 460265016132 Q-loop/lid; other site 460265016133 ABC transporter signature motif; other site 460265016134 Walker B; other site 460265016135 D-loop; other site 460265016136 H-loop/switch region; other site 460265016137 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 460265016138 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 460265016139 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 460265016140 Trp docking motif [polypeptide binding]; other site 460265016141 dimer interface [polypeptide binding]; other site 460265016142 active site 460265016143 small subunit binding site [polypeptide binding]; other site 460265016144 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 460265016145 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 460265016146 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265016147 substrate binding pocket [chemical binding]; other site 460265016148 membrane-bound complex binding site; other site 460265016149 hinge residues; other site 460265016150 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 460265016151 active site residue [active] 460265016152 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 460265016153 catalytic center binding site [active] 460265016154 ATP binding site [chemical binding]; other site 460265016155 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 460265016156 homooctamer interface [polypeptide binding]; other site 460265016157 active site 460265016158 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 460265016159 dihydropteroate synthase; Region: DHPS; TIGR01496 460265016160 substrate binding pocket [chemical binding]; other site 460265016161 dimer interface [polypeptide binding]; other site 460265016162 inhibitor binding site; inhibition site 460265016163 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 460265016164 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 460265016165 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 460265016166 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 460265016167 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265016168 FeS/SAM binding site; other site 460265016169 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 460265016170 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 460265016171 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 460265016172 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 460265016173 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 460265016174 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 460265016175 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 460265016176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265016177 active site 460265016178 phosphorylation site [posttranslational modification] 460265016179 intermolecular recognition site; other site 460265016180 dimerization interface [polypeptide binding]; other site 460265016181 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265016182 DNA binding site [nucleotide binding] 460265016183 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265016184 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 460265016185 dimerization interface [polypeptide binding]; other site 460265016186 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265016187 dimer interface [polypeptide binding]; other site 460265016188 phosphorylation site [posttranslational modification] 460265016189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265016190 ATP binding site [chemical binding]; other site 460265016191 Mg2+ binding site [ion binding]; other site 460265016192 G-X-G motif; other site 460265016193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265016194 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 460265016195 NAD(P) binding site [chemical binding]; other site 460265016196 active site 460265016197 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265016198 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265016199 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265016200 dimerization interface [polypeptide binding]; other site 460265016201 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 460265016202 domain_subunit interface; other site 460265016203 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 460265016204 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 460265016205 FTR, proximal lobe; Region: FTR_C; pfam02741 460265016206 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 460265016207 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 460265016208 active site 460265016209 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 460265016210 molybdopterin cofactor binding site; other site 460265016211 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 460265016212 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 460265016213 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 460265016214 NADP binding site [chemical binding]; other site 460265016215 ATP-grasp domain; Region: ATP-grasp_4; cl17255 460265016216 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 460265016217 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 460265016218 trimer interface I [polypeptide binding]; other site 460265016219 putative substrate binding pocket [chemical binding]; other site 460265016220 trimer interface II [polypeptide binding]; other site 460265016221 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 460265016222 ATP-grasp domain; Region: ATP-grasp_4; cl17255 460265016223 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 460265016224 formaldehyde-activating enzyme; Region: one_C_fae; TIGR03126 460265016225 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 460265016226 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 460265016227 active site 460265016228 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 460265016229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265016230 dimer interface [polypeptide binding]; other site 460265016231 phosphorylation site [posttranslational modification] 460265016232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265016233 ATP binding site [chemical binding]; other site 460265016234 Mg2+ binding site [ion binding]; other site 460265016235 G-X-G motif; other site 460265016236 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 460265016237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265016238 active site 460265016239 phosphorylation site [posttranslational modification] 460265016240 intermolecular recognition site; other site 460265016241 dimerization interface [polypeptide binding]; other site 460265016242 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 460265016243 putative active site pocket [active] 460265016244 dimerization interface [polypeptide binding]; other site 460265016245 putative catalytic residue [active] 460265016246 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 460265016247 Zn binding site [ion binding]; other site 460265016248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265016249 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265016250 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265016251 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 460265016252 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 460265016253 [2Fe-2S] cluster binding site [ion binding]; other site 460265016254 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 460265016255 hydrophobic ligand binding site; other site 460265016256 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 460265016257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265016258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265016259 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 460265016260 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 460265016261 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 460265016262 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 460265016263 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 460265016264 aminotransferase; Validated; Region: PRK09148 460265016265 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 460265016266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265016267 homodimer interface [polypeptide binding]; other site 460265016268 catalytic residue [active] 460265016269 glycine dehydrogenase; Provisional; Region: PRK05367 460265016270 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 460265016271 tetramer interface [polypeptide binding]; other site 460265016272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265016273 catalytic residue [active] 460265016274 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 460265016275 tetramer interface [polypeptide binding]; other site 460265016276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265016277 catalytic residue [active] 460265016278 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 460265016279 lipoyl attachment site [posttranslational modification]; other site 460265016280 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 460265016281 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 460265016282 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 460265016283 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 460265016284 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 460265016285 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 460265016286 active site 460265016287 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 460265016288 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 460265016289 TSCPD domain; Region: TSCPD; pfam12637 460265016290 NADH dehydrogenase; Validated; Region: PRK08183 460265016291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 460265016292 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 460265016293 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 460265016294 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 460265016295 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 460265016296 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 460265016297 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 460265016298 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 460265016299 carboxyltransferase (CT) interaction site; other site 460265016300 biotinylation site [posttranslational modification]; other site 460265016301 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 460265016302 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 460265016303 catalytic residues [active] 460265016304 hypothetical protein; Provisional; Region: PRK08960 460265016305 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 460265016306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265016307 homodimer interface [polypeptide binding]; other site 460265016308 catalytic residue [active] 460265016309 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 460265016310 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 460265016311 dimer interface [polypeptide binding]; other site 460265016312 putative CheW interface [polypeptide binding]; other site 460265016313 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 460265016314 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 460265016315 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 460265016316 AMIN domain; Region: AMIN; pfam11741 460265016317 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 460265016318 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 460265016319 active site 460265016320 metal binding site [ion binding]; metal-binding site 460265016321 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 460265016322 Transglycosylase; Region: Transgly; pfam00912 460265016323 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 460265016324 peptide chain release factor 2; Validated; Region: prfB; PRK00578 460265016325 This domain is found in peptide chain release factors; Region: PCRF; smart00937 460265016326 RF-1 domain; Region: RF-1; pfam00472 460265016327 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 460265016328 Peptidase family M23; Region: Peptidase_M23; pfam01551 460265016329 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 460265016330 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 460265016331 catalytic triad [active] 460265016332 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 460265016333 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 460265016334 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 460265016335 substrate binding site [chemical binding]; other site 460265016336 dimer interface [polypeptide binding]; other site 460265016337 ATP binding site [chemical binding]; other site 460265016338 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 460265016339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265016340 DNA-binding site [nucleotide binding]; DNA binding site 460265016341 UTRA domain; Region: UTRA; pfam07702 460265016342 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 460265016343 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 460265016344 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 460265016345 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 460265016346 FliG C-terminal domain; Region: FliG_C; pfam01706 460265016347 flagellar assembly protein H; Validated; Region: fliH; PRK06032 460265016348 Flagellar assembly protein FliH; Region: FliH; pfam02108 460265016349 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 460265016350 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 460265016351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265016352 Walker A motif; other site 460265016353 ATP binding site [chemical binding]; other site 460265016354 Walker B motif; other site 460265016355 arginine finger; other site 460265016356 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 460265016357 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 460265016358 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 460265016359 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 460265016360 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 460265016361 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 460265016362 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 460265016363 Ligand Binding Site [chemical binding]; other site 460265016364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265016365 S-adenosylmethionine binding site [chemical binding]; other site 460265016366 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 460265016367 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265016368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265016369 ATP binding site [chemical binding]; other site 460265016370 Mg2+ binding site [ion binding]; other site 460265016371 G-X-G motif; other site 460265016372 biotin synthase; Region: bioB; TIGR00433 460265016373 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265016374 FeS/SAM binding site; other site 460265016375 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 460265016376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265016377 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265016378 dimerization interface [polypeptide binding]; other site 460265016379 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 460265016380 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265016381 FeS/SAM binding site; other site 460265016382 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 460265016383 MPT binding site; other site 460265016384 trimer interface [polypeptide binding]; other site 460265016385 Predicted metalloprotease [General function prediction only]; Region: COG2321 460265016386 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 460265016387 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 460265016388 Fe-S cluster binding site [ion binding]; other site 460265016389 active site 460265016390 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 460265016391 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 460265016392 acyl-CoA synthetase; Validated; Region: PRK07470 460265016393 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 460265016394 acyl-activating enzyme (AAE) consensus motif; other site 460265016395 putative AMP binding site [chemical binding]; other site 460265016396 putative active site [active] 460265016397 putative CoA binding site [chemical binding]; other site 460265016398 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 460265016399 RNA/DNA hybrid binding site [nucleotide binding]; other site 460265016400 active site 460265016401 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 460265016402 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 460265016403 active site 460265016404 Protein of unknown function, DUF488; Region: DUF488; pfam04343 460265016405 ATP-NAD kinase; Region: NAD_kinase; pfam01513 460265016406 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 460265016407 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 460265016408 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 460265016409 allantoate amidohydrolase; Reviewed; Region: PRK12893 460265016410 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 460265016411 active site 460265016412 metal binding site [ion binding]; metal-binding site 460265016413 dimer interface [polypeptide binding]; other site 460265016414 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 460265016415 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 460265016416 FMN binding site [chemical binding]; other site 460265016417 substrate binding site [chemical binding]; other site 460265016418 putative catalytic residue [active] 460265016419 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 460265016420 Beta-lactamase; Region: Beta-lactamase; pfam00144 460265016421 Predicted integral membrane protein [Function unknown]; Region: COG5473 460265016422 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 460265016423 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265016424 Walker A/P-loop; other site 460265016425 ATP binding site [chemical binding]; other site 460265016426 Q-loop/lid; other site 460265016427 ABC transporter signature motif; other site 460265016428 Walker B; other site 460265016429 D-loop; other site 460265016430 H-loop/switch region; other site 460265016431 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265016432 Walker A/P-loop; other site 460265016433 ATP binding site [chemical binding]; other site 460265016434 Q-loop/lid; other site 460265016435 ABC transporter signature motif; other site 460265016436 Walker B; other site 460265016437 D-loop; other site 460265016438 H-loop/switch region; other site 460265016439 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 460265016440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265016441 dimer interface [polypeptide binding]; other site 460265016442 conserved gate region; other site 460265016443 ABC-ATPase subunit interface; other site 460265016444 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 460265016445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265016446 dimer interface [polypeptide binding]; other site 460265016447 conserved gate region; other site 460265016448 putative PBP binding loops; other site 460265016449 ABC-ATPase subunit interface; other site 460265016450 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 460265016451 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 460265016452 peptide binding site [polypeptide binding]; other site 460265016453 Domain of unknown function (DUF336); Region: DUF336; cl01249 460265016454 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265016455 binding surface 460265016456 TPR motif; other site 460265016457 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 460265016458 active site residue [active] 460265016459 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 460265016460 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 460265016461 Chromate transporter; Region: Chromate_transp; pfam02417 460265016462 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265016463 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265016464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 460265016465 Winged helix-turn helix; Region: HTH_29; pfam13551 460265016466 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265016467 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 460265016468 Low affinity iron permease; Region: Iron_permease; pfam04120 460265016469 DDE domain; Region: DDE_Tnp_IS240; pfam13610 460265016470 Integrase core domain; Region: rve; pfam00665 460265016471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 460265016472 TPR motif; other site 460265016473 binding surface 460265016474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 460265016475 binding surface 460265016476 TPR motif; other site 460265016477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265016478 binding surface 460265016479 TPR motif; other site 460265016480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 460265016481 binding surface 460265016482 TPR motif; other site 460265016483 TIR domain; Region: TIR_2; pfam13676 460265016484 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 460265016485 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 460265016486 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265016487 Uncharacterized conserved protein [Function unknown]; Region: COG5649 460265016488 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265016489 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265016490 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265016491 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265016492 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265016493 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 460265016494 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265016495 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265016496 ligand binding site [chemical binding]; other site 460265016497 flexible hinge region; other site 460265016498 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 460265016499 DDE domain; Region: DDE_Tnp_IS240; pfam13610 460265016500 Integrase core domain; Region: rve; pfam00665 460265016501 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 460265016502 BON domain; Region: BON; pfam04972 460265016503 BON domain; Region: BON; pfam04972 460265016504 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 460265016505 Ligand Binding Site [chemical binding]; other site 460265016506 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265016507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265016508 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265016509 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 460265016510 RibD C-terminal domain; Region: RibD_C; cl17279 460265016511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265016512 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 460265016513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 460265016514 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 460265016515 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 460265016516 active site 460265016517 catalytic tetrad [active] 460265016518 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 460265016519 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 460265016520 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 460265016521 active site 460265016522 catalytic tetrad [active] 460265016523 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 460265016524 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 460265016525 active site 460265016526 catalytic tetrad [active] 460265016527 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 460265016528 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 460265016529 active site 460265016530 catalytic tetrad [active] 460265016531 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 460265016532 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 460265016533 putative NAD(P) binding site [chemical binding]; other site 460265016534 putative substrate binding site [chemical binding]; other site 460265016535 catalytic Zn binding site [ion binding]; other site 460265016536 structural Zn binding site [ion binding]; other site 460265016537 dimer interface [polypeptide binding]; other site 460265016538 Winged helix-turn helix; Region: HTH_29; pfam13551 460265016539 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265016540 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 460265016541 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265016542 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 460265016543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265016544 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265016545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265016546 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 460265016547 putative effector binding pocket; other site 460265016548 putative dimerization interface [polypeptide binding]; other site 460265016549 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 460265016550 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 460265016551 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 460265016552 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 460265016553 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 460265016554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 460265016555 motif II; other site 460265016556 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 460265016557 Cytochrome c; Region: Cytochrom_C; pfam00034 460265016558 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 460265016559 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 460265016560 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 460265016561 PAS fold; Region: PAS; pfam00989 460265016562 PAS domain S-box; Region: sensory_box; TIGR00229 460265016563 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265016564 putative active site [active] 460265016565 heme pocket [chemical binding]; other site 460265016566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265016567 dimer interface [polypeptide binding]; other site 460265016568 phosphorylation site [posttranslational modification] 460265016569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265016570 ATP binding site [chemical binding]; other site 460265016571 Mg2+ binding site [ion binding]; other site 460265016572 G-X-G motif; other site 460265016573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265016574 active site 460265016575 phosphorylation site [posttranslational modification] 460265016576 intermolecular recognition site; other site 460265016577 dimerization interface [polypeptide binding]; other site 460265016578 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 460265016579 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265016580 ligand binding site [chemical binding]; other site 460265016581 flexible hinge region; other site 460265016582 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 460265016583 putative switch regulator; other site 460265016584 non-specific DNA interactions [nucleotide binding]; other site 460265016585 DNA binding site [nucleotide binding] 460265016586 sequence specific DNA binding site [nucleotide binding]; other site 460265016587 putative cAMP binding site [chemical binding]; other site 460265016588 osmolarity response regulator; Provisional; Region: ompR; PRK09468 460265016589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265016590 active site 460265016591 phosphorylation site [posttranslational modification] 460265016592 intermolecular recognition site; other site 460265016593 dimerization interface [polypeptide binding]; other site 460265016594 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265016595 DNA binding site [nucleotide binding] 460265016596 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 460265016597 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 460265016598 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 460265016599 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 460265016600 Soluble P-type ATPase [General function prediction only]; Region: COG4087 460265016601 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 460265016602 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 460265016603 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 460265016604 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 460265016605 response regulator; Provisional; Region: PRK13435 460265016606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 460265016607 Predicted kinase [General function prediction only]; Region: COG0645 460265016608 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 460265016609 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 460265016610 FOG: CBS domain [General function prediction only]; Region: COG0517 460265016611 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 460265016612 BON domain; Region: BON; pfam04972 460265016613 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 460265016614 Ligand Binding Site [chemical binding]; other site 460265016615 putative phosphoketolase; Provisional; Region: PRK05261 460265016616 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 460265016617 TPP-binding site; other site 460265016618 XFP C-terminal domain; Region: XFP_C; pfam09363 460265016619 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 460265016620 BON domain; Region: BON; pfam04972 460265016621 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 460265016622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265016623 TPR repeat; Region: TPR_11; pfam13414 460265016624 binding surface 460265016625 TPR motif; other site 460265016626 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 460265016627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265016628 binding surface 460265016629 TPR motif; other site 460265016630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265016631 binding surface 460265016632 TPR motif; other site 460265016633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265016634 binding surface 460265016635 TPR motif; other site 460265016636 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 460265016637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265016638 binding surface 460265016639 TPR motif; other site 460265016640 Tetratricopeptide repeat; Region: TPR_1; pfam00515 460265016641 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 460265016642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265016643 binding surface 460265016644 TPR motif; other site 460265016645 Tetratricopeptide repeat; Region: TPR_1; pfam00515 460265016646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265016647 binding surface 460265016648 TPR motif; other site 460265016649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265016650 binding surface 460265016651 TPR repeat; Region: TPR_11; pfam13414 460265016652 TPR motif; other site 460265016653 TPR repeat; Region: TPR_11; pfam13414 460265016654 Caspase domain; Region: Peptidase_C14; pfam00656 460265016655 Sel1-like repeats; Region: SEL1; smart00671 460265016656 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 460265016657 Sel1-like repeats; Region: SEL1; smart00671 460265016658 Sel1-like repeats; Region: SEL1; smart00671 460265016659 Sel1 repeat; Region: Sel1; cl02723 460265016660 Sel1-like repeats; Region: SEL1; smart00671 460265016661 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 460265016662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 460265016663 Transposase; Region: DDE_Tnp_ISL3; pfam01610 460265016664 Transposase; Region: DDE_Tnp_ISL3; pfam01610 460265016665 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 460265016666 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 460265016667 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 460265016668 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 460265016669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265016670 ATP binding site [chemical binding]; other site 460265016671 Mg2+ binding site [ion binding]; other site 460265016672 G-X-G motif; other site 460265016673 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 460265016674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265016675 active site 460265016676 phosphorylation site [posttranslational modification] 460265016677 intermolecular recognition site; other site 460265016678 dimerization interface [polypeptide binding]; other site 460265016679 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265016680 DNA binding site [nucleotide binding] 460265016681 Predicted membrane protein [Function unknown]; Region: COG3212 460265016682 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 460265016683 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 460265016684 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 460265016685 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 460265016686 putative NAD(P) binding site [chemical binding]; other site 460265016687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265016688 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 460265016689 non-specific DNA binding site [nucleotide binding]; other site 460265016690 salt bridge; other site 460265016691 sequence-specific DNA binding site [nucleotide binding]; other site 460265016692 Domain of unknown function (DUF932); Region: DUF932; cl12129 460265016693 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 460265016694 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 460265016695 pore gating glutamate residue; other site 460265016696 CsbD-like; Region: CsbD; pfam05532 460265016697 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 460265016698 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265016699 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 460265016700 putative active site [active] 460265016701 heme pocket [chemical binding]; other site 460265016702 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265016703 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 460265016704 putative active site [active] 460265016705 heme pocket [chemical binding]; other site 460265016706 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265016707 putative active site [active] 460265016708 heme pocket [chemical binding]; other site 460265016709 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 460265016710 GAF domain; Region: GAF; pfam01590 460265016711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265016712 dimer interface [polypeptide binding]; other site 460265016713 phosphorylation site [posttranslational modification] 460265016714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265016715 ATP binding site [chemical binding]; other site 460265016716 Mg2+ binding site [ion binding]; other site 460265016717 G-X-G motif; other site 460265016718 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 460265016719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265016720 active site 460265016721 phosphorylation site [posttranslational modification] 460265016722 intermolecular recognition site; other site 460265016723 dimerization interface [polypeptide binding]; other site 460265016724 histidine kinase; Provisional; Region: PRK13557 460265016725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265016726 putative active site [active] 460265016727 heme pocket [chemical binding]; other site 460265016728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265016729 dimer interface [polypeptide binding]; other site 460265016730 phosphorylation site [posttranslational modification] 460265016731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265016732 ATP binding site [chemical binding]; other site 460265016733 Mg2+ binding site [ion binding]; other site 460265016734 G-X-G motif; other site 460265016735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265016736 active site 460265016737 phosphorylation site [posttranslational modification] 460265016738 intermolecular recognition site; other site 460265016739 dimerization interface [polypeptide binding]; other site 460265016740 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 460265016741 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 460265016742 catalytic residue [active] 460265016743 Phage-related protein, tail component [Function unknown]; Region: COG4733 460265016744 Putative phage tail protein; Region: Phage-tail_3; pfam13550 460265016745 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 460265016746 Interdomain contacts; other site 460265016747 Cytokine receptor motif; other site 460265016748 Phage-related protein, tail component [Function unknown]; Region: COG4723 460265016749 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 460265016750 Phage minor tail protein L; Region: Phage_tail_L; cl01908 460265016751 Phage minor tail protein; Region: Phage_min_tail; cl01940 460265016752 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 460265016753 Phage-related minor tail protein [Function unknown]; Region: COG5281 460265016754 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265016755 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265016756 catalytic residue [active] 460265016757 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 460265016758 LAGLIDADG endonuclease; Region: LAGLIDADG_1; pfam00961 460265016759 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 460265016760 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 460265016761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 460265016762 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 460265016763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566 460265016764 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 460265016765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567 460265016766 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 460265016767 hypothetical protein; Provisional; Region: 57B; PHA02574 460265016768 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265016769 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 460265016770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 460265016771 Winged helix-turn helix; Region: HTH_29; pfam13551 460265016772 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265016773 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 460265016774 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 460265016775 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265016776 FeS/SAM binding site; other site 460265016777 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 460265016778 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 460265016779 active site 460265016780 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 460265016781 Ligand Binding Site [chemical binding]; other site 460265016782 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 460265016783 ParB-like nuclease domain; Region: ParBc; pfam02195 460265016784 transcriptional activator RfaH; Region: RfaH; TIGR01955 460265016785 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 460265016786 heterodimer interface [polypeptide binding]; other site 460265016787 homodimer interface [polypeptide binding]; other site 460265016788 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 460265016789 replicative DNA helicase; Region: DnaB; TIGR00665 460265016790 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 460265016791 Walker A motif; other site 460265016792 ATP binding site [chemical binding]; other site 460265016793 Walker B motif; other site 460265016794 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 460265016795 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 460265016796 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265016797 non-specific DNA binding site [nucleotide binding]; other site 460265016798 salt bridge; other site 460265016799 sequence-specific DNA binding site [nucleotide binding]; other site 460265016800 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 460265016801 RecT family; Region: RecT; cl04285 460265016802 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 460265016803 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 460265016804 DNA binding site [nucleotide binding] 460265016805 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 460265016806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265016807 non-specific DNA binding site [nucleotide binding]; other site 460265016808 salt bridge; other site 460265016809 sequence-specific DNA binding site [nucleotide binding]; other site 460265016810 Helix-turn-helix domain; Region: HTH_17; cl17695 460265016811 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 460265016812 active site 460265016813 Int/Topo IB signature motif; other site 460265016814 catalytic residues [active] 460265016815 DNA binding site [nucleotide binding] 460265016816 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 460265016817 lipoate-protein ligase B; Provisional; Region: PRK14341 460265016818 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 460265016819 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265016820 active site 460265016821 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 460265016822 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265016823 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cd11296 460265016824 GDP-Fucose binding site [chemical binding]; other site 460265016825 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 460265016826 Methyltransferase domain; Region: Methyltransf_24; pfam13578 460265016827 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265016828 Protein of unknown function (DUF563); Region: DUF563; pfam04577 460265016829 Family description; Region: VCBS; pfam13517 460265016830 Family description; Region: VCBS; pfam13517 460265016831 Family description; Region: VCBS; pfam13517 460265016832 Family description; Region: VCBS; pfam13517 460265016833 Family description; Region: VCBS; pfam13517 460265016834 Family description; Region: VCBS; pfam13517 460265016835 Family description; Region: VCBS; pfam13517 460265016836 Family description; Region: VCBS; pfam13517 460265016837 Family description; Region: VCBS; pfam13517 460265016838 Family description; Region: VCBS; pfam13517 460265016839 Family description; Region: VCBS; pfam13517 460265016840 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 460265016841 active site 460265016842 catalytic triad [active] 460265016843 oxyanion hole [active] 460265016844 Methyltransferase domain; Region: Methyltransf_12; pfam08242 460265016845 Methyltransferase domain; Region: Methyltransf_24; pfam13578 460265016846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 460265016847 Transposase; Region: HTH_Tnp_1; pfam01527 460265016848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 460265016849 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 460265016850 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 460265016851 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 460265016852 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 460265016853 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 460265016854 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 460265016855 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 460265016856 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 460265016857 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265016858 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 460265016859 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 460265016860 putative ligand binding site [chemical binding]; other site 460265016861 putative catalytic site [active] 460265016862 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 460265016863 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 460265016864 Probable Catalytic site; other site 460265016865 metal-binding site 460265016866 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 460265016867 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 460265016868 NADP binding site [chemical binding]; other site 460265016869 active site 460265016870 putative substrate binding site [chemical binding]; other site 460265016871 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 460265016872 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 460265016873 NADP-binding site; other site 460265016874 homotetramer interface [polypeptide binding]; other site 460265016875 substrate binding site [chemical binding]; other site 460265016876 homodimer interface [polypeptide binding]; other site 460265016877 active site 460265016878 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 460265016879 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 460265016880 Substrate binding site; other site 460265016881 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 460265016882 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 460265016883 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265016884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265016885 metabolite-proton symporter; Region: 2A0106; TIGR00883 460265016886 Methyltransferase domain; Region: Methyltransf_25; pfam13649 460265016887 S-adenosylmethionine binding site [chemical binding]; other site 460265016888 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 460265016889 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 460265016890 metal binding site [ion binding]; metal-binding site 460265016891 active site 460265016892 I-site; other site 460265016893 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 460265016894 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 460265016895 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 460265016896 dimerization interface [polypeptide binding]; other site 460265016897 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 460265016898 dimerization interface [polypeptide binding]; other site 460265016899 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 460265016900 dimerization interface [polypeptide binding]; other site 460265016901 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 460265016902 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 460265016903 dimerization interface [polypeptide binding]; other site 460265016904 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 460265016905 dimerization interface [polypeptide binding]; other site 460265016906 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 460265016907 dimerization interface [polypeptide binding]; other site 460265016908 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 460265016909 dimerization interface [polypeptide binding]; other site 460265016910 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 460265016911 dimerization interface [polypeptide binding]; other site 460265016912 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 460265016913 GAF domain; Region: GAF; pfam01590 460265016914 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265016915 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265016916 dimer interface [polypeptide binding]; other site 460265016917 phosphorylation site [posttranslational modification] 460265016918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265016919 ATP binding site [chemical binding]; other site 460265016920 Mg2+ binding site [ion binding]; other site 460265016921 G-X-G motif; other site 460265016922 Response regulator receiver domain; Region: Response_reg; pfam00072 460265016923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265016924 active site 460265016925 phosphorylation site [posttranslational modification] 460265016926 intermolecular recognition site; other site 460265016927 dimerization interface [polypeptide binding]; other site 460265016928 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 460265016929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265016930 active site 460265016931 phosphorylation site [posttranslational modification] 460265016932 intermolecular recognition site; other site 460265016933 dimerization interface [polypeptide binding]; other site 460265016934 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 460265016935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265016936 active site 460265016937 phosphorylation site [posttranslational modification] 460265016938 intermolecular recognition site; other site 460265016939 dimerization interface [polypeptide binding]; other site 460265016940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265016941 active site 460265016942 phosphorylation site [posttranslational modification] 460265016943 intermolecular recognition site; other site 460265016944 PAS fold; Region: PAS_3; pfam08447 460265016945 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265016946 heme pocket [chemical binding]; other site 460265016947 putative active site [active] 460265016948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265016949 dimer interface [polypeptide binding]; other site 460265016950 phosphorylation site [posttranslational modification] 460265016951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265016952 ATP binding site [chemical binding]; other site 460265016953 Mg2+ binding site [ion binding]; other site 460265016954 G-X-G motif; other site 460265016955 Response regulator receiver domain; Region: Response_reg; pfam00072 460265016956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265016957 active site 460265016958 phosphorylation site [posttranslational modification] 460265016959 intermolecular recognition site; other site 460265016960 dimerization interface [polypeptide binding]; other site 460265016961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 460265016962 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 460265016963 AAA domain; Region: AAA_26; pfam13500 460265016964 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 460265016965 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 460265016966 catalytic residue [active] 460265016967 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 460265016968 Transcriptional regulators [Transcription]; Region: MarR; COG1846 460265016969 MarR family; Region: MarR_2; pfam12802 460265016970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 460265016971 Coenzyme A binding pocket [chemical binding]; other site 460265016972 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 460265016973 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 460265016974 inhibitor-cofactor binding pocket; inhibition site 460265016975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265016976 catalytic residue [active] 460265016977 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 460265016978 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 460265016979 motif II; other site 460265016980 NAD-dependent deacetylase; Provisional; Region: PRK00481 460265016981 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 460265016982 NAD+ binding site [chemical binding]; other site 460265016983 substrate binding site [chemical binding]; other site 460265016984 Zn binding site [ion binding]; other site 460265016985 putative assembly protein; Provisional; Region: PRK10833 460265016986 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 460265016987 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 460265016988 D-galactonate transporter; Region: 2A0114; TIGR00893 460265016989 D-galactonate transporter; Region: 2A0114; TIGR00893 460265016990 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 460265016991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265016992 dimer interface [polypeptide binding]; other site 460265016993 conserved gate region; other site 460265016994 putative PBP binding loops; other site 460265016995 ABC-ATPase subunit interface; other site 460265016996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 460265016997 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 460265016998 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 460265016999 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 460265017000 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 460265017001 Walker A/P-loop; other site 460265017002 ATP binding site [chemical binding]; other site 460265017003 Q-loop/lid; other site 460265017004 ABC transporter signature motif; other site 460265017005 Walker B; other site 460265017006 D-loop; other site 460265017007 H-loop/switch region; other site 460265017008 TOBE domain; Region: TOBE_2; pfam08402 460265017009 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 460265017010 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 460265017011 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 460265017012 Ligand binding site; other site 460265017013 Putative Catalytic site; other site 460265017014 DXD motif; other site 460265017015 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 460265017016 Domain of unknown function DUF302; Region: DUF302; cl01364 460265017017 cystathionine beta-lyase; Provisional; Region: PRK05967 460265017018 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 460265017019 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 460265017020 catalytic residue [active] 460265017021 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 460265017022 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265017023 substrate binding pocket [chemical binding]; other site 460265017024 membrane-bound complex binding site; other site 460265017025 hinge residues; other site 460265017026 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 460265017027 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 460265017028 Walker A/P-loop; other site 460265017029 ATP binding site [chemical binding]; other site 460265017030 Q-loop/lid; other site 460265017031 ABC transporter signature motif; other site 460265017032 Walker B; other site 460265017033 D-loop; other site 460265017034 H-loop/switch region; other site 460265017035 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 460265017036 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 460265017037 active site residue [active] 460265017038 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 460265017039 active site residue [active] 460265017040 Phasin protein; Region: Phasin_2; cl11491 460265017041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 460265017042 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 460265017043 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 460265017044 hydroxyglutarate oxidase; Provisional; Region: PRK11728 460265017045 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265017046 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265017047 DNA-binding site [nucleotide binding]; DNA binding site 460265017048 FCD domain; Region: FCD; pfam07729 460265017049 citrate-proton symporter; Provisional; Region: PRK15075 460265017050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265017051 putative substrate translocation pore; other site 460265017052 tricarballylate dehydrogenase; Validated; Region: PRK08274 460265017053 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 460265017054 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 460265017055 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 460265017056 NAD(P) binding site [chemical binding]; other site 460265017057 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 460265017058 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 460265017059 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 460265017060 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265017061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265017062 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265017063 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 460265017064 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 460265017065 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265017066 Low affinity iron permease; Region: Iron_permease; pfam04120 460265017067 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 460265017068 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 460265017069 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265017070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 460265017071 Winged helix-turn helix; Region: HTH_29; pfam13551 460265017072 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265017073 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 460265017074 Transposase IS200 like; Region: Y1_Tnp; cl00848 460265017075 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 460265017076 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 460265017077 active site 460265017078 catalytic tetrad [active] 460265017079 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 460265017080 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265017081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265017082 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 460265017083 putative effector binding pocket; other site 460265017084 putative dimerization interface [polypeptide binding]; other site 460265017085 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 460265017086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265017087 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 460265017088 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265017089 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265017090 SnoaL-like domain; Region: SnoaL_2; pfam12680 460265017091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 460265017092 MOSC domain; Region: MOSC; pfam03473 460265017093 3-alpha domain; Region: 3-alpha; pfam03475 460265017094 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 460265017095 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 460265017096 FAD binding pocket [chemical binding]; other site 460265017097 FAD binding motif [chemical binding]; other site 460265017098 phosphate binding motif [ion binding]; other site 460265017099 beta-alpha-beta structure motif; other site 460265017100 NAD binding pocket [chemical binding]; other site 460265017101 Heme binding pocket [chemical binding]; other site 460265017102 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265017103 catalytic loop [active] 460265017104 iron binding site [ion binding]; other site 460265017105 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 460265017106 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 460265017107 active site 460265017108 catalytic tetrad [active] 460265017109 Transposase domain (DUF772); Region: DUF772; pfam05598 460265017110 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265017111 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 460265017112 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 460265017113 putative NAD(P) binding site [chemical binding]; other site 460265017114 short chain dehydrogenase; Provisional; Region: PRK06179 460265017115 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 460265017116 NADP binding site [chemical binding]; other site 460265017117 active site 460265017118 steroid binding site; other site 460265017119 Transcriptional regulators [Transcription]; Region: MarR; COG1846 460265017120 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 460265017121 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 460265017122 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 460265017123 catalytic residues [active] 460265017124 catalytic nucleophile [active] 460265017125 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 460265017126 DNA-binding interface [nucleotide binding]; DNA binding site 460265017127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265017128 active site 460265017129 phosphorylation site [posttranslational modification] 460265017130 intermolecular recognition site; other site 460265017131 dimerization interface [polypeptide binding]; other site 460265017132 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 460265017133 GAF domain; Region: GAF; pfam01590 460265017134 PAS domain S-box; Region: sensory_box; TIGR00229 460265017135 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265017136 putative active site [active] 460265017137 heme pocket [chemical binding]; other site 460265017138 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265017139 PAS domain; Region: PAS_9; pfam13426 460265017140 putative active site [active] 460265017141 heme pocket [chemical binding]; other site 460265017142 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 460265017143 HWE histidine kinase; Region: HWE_HK; smart00911 460265017144 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 460265017145 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 460265017146 Transposase; Region: HTH_Tnp_1; cl17663 460265017147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 460265017148 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265017149 putative transposase OrfB; Reviewed; Region: PHA02517 460265017150 Homeodomain-like domain; Region: HTH_32; pfam13565 460265017151 Integrase core domain; Region: rve; pfam00665 460265017152 Integrase core domain; Region: rve_3; pfam13683 460265017153 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 460265017154 MarR family; Region: MarR_2; cl17246 460265017155 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 460265017156 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265017157 substrate binding site [chemical binding]; other site 460265017158 oxyanion hole (OAH) forming residues; other site 460265017159 trimer interface [polypeptide binding]; other site 460265017160 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 460265017161 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 460265017162 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 460265017163 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 460265017164 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265017165 acyl-activating enzyme (AAE) consensus motif; other site 460265017166 AMP binding site [chemical binding]; other site 460265017167 active site 460265017168 CoA binding site [chemical binding]; other site 460265017169 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 460265017170 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 460265017171 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265017172 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265017173 putative ligand binding site [chemical binding]; other site 460265017174 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 460265017175 active site 460265017176 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265017177 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265017178 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265017179 Transposase domain (DUF772); Region: DUF772; pfam05598 460265017180 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265017181 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265017182 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 460265017183 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 460265017184 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 460265017185 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 460265017186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566 460265017187 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 460265017188 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 460265017189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 460265017190 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 460265017191 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 460265017192 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 460265017193 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 460265017194 HIGH motif; other site 460265017195 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 460265017196 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 460265017197 active site 460265017198 KMSKS motif; other site 460265017199 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 460265017200 tRNA binding surface [nucleotide binding]; other site 460265017201 anticodon binding site; other site 460265017202 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 460265017203 Animal prostaglandin endoperoxide synthase and related bacterial proteins; Region: prostaglandin_endoperoxide_synthase; cd09816 460265017204 substrate binding site [chemical binding]; other site 460265017205 homodimer interface [polypeptide binding]; other site 460265017206 heme binding site [chemical binding]; other site 460265017207 allene oxide synthase; Region: PLN02648 460265017208 Cytochrome P450; Region: p450; cl12078 460265017209 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 460265017210 cyclase homology domain; Region: CHD; cd07302 460265017211 nucleotidyl binding site; other site 460265017212 metal binding site [ion binding]; metal-binding site 460265017213 dimer interface [polypeptide binding]; other site 460265017214 AAA ATPase domain; Region: AAA_16; pfam13191 460265017215 Uncharacterized conserved protein [Function unknown]; Region: COG1742 460265017216 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 460265017217 putative metal binding site [ion binding]; other site 460265017218 putative homodimer interface [polypeptide binding]; other site 460265017219 putative homotetramer interface [polypeptide binding]; other site 460265017220 putative homodimer-homodimer interface [polypeptide binding]; other site 460265017221 putative allosteric switch controlling residues; other site 460265017222 High-affinity nickel-transport protein; Region: NicO; cl00964 460265017223 High-affinity nickel-transport protein; Region: NicO; cl00964 460265017224 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 460265017225 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 460265017226 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 460265017227 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 460265017228 protein binding site [polypeptide binding]; other site 460265017229 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 460265017230 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 460265017231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265017232 putative substrate translocation pore; other site 460265017233 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 460265017234 enolase; Provisional; Region: eno; PRK00077 460265017235 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 460265017236 dimer interface [polypeptide binding]; other site 460265017237 metal binding site [ion binding]; metal-binding site 460265017238 substrate binding pocket [chemical binding]; other site 460265017239 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 460265017240 EamA-like transporter family; Region: EamA; pfam00892 460265017241 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 460265017242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265017243 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 460265017244 Septum formation initiator; Region: DivIC; cl17659 460265017245 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 460265017246 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 460265017247 tetramer interface [polypeptide binding]; other site 460265017248 TPP-binding site [chemical binding]; other site 460265017249 heterodimer interface [polypeptide binding]; other site 460265017250 phosphorylation loop region [posttranslational modification] 460265017251 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 460265017252 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 460265017253 E3 interaction surface; other site 460265017254 lipoyl attachment site [posttranslational modification]; other site 460265017255 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 460265017256 alpha subunit interface [polypeptide binding]; other site 460265017257 TPP binding site [chemical binding]; other site 460265017258 heterodimer interface [polypeptide binding]; other site 460265017259 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 460265017260 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 460265017261 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 460265017262 E3 interaction surface; other site 460265017263 lipoyl attachment site [posttranslational modification]; other site 460265017264 e3 binding domain; Region: E3_binding; pfam02817 460265017265 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 460265017266 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 460265017267 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 460265017268 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 460265017269 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 460265017270 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 460265017271 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265017272 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265017273 DNA binding residues [nucleotide binding] 460265017274 dimerization interface [polypeptide binding]; other site 460265017275 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 460265017276 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 460265017277 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 460265017278 dimer interface [polypeptide binding]; other site 460265017279 circadian clock protein KaiC; Reviewed; Region: PRK09302 460265017280 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 460265017281 Walker A motif; other site 460265017282 ATP binding site [chemical binding]; other site 460265017283 Walker B motif; other site 460265017284 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 460265017285 Walker A motif; other site 460265017286 ATP binding site [chemical binding]; other site 460265017287 Walker B motif; other site 460265017288 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 460265017289 HWE histidine kinase; Region: HWE_HK; pfam07536 460265017290 lipoyl synthase; Provisional; Region: PRK05481 460265017291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265017292 FeS/SAM binding site; other site 460265017293 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 460265017294 putative coenzyme Q binding site [chemical binding]; other site 460265017295 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 460265017296 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 460265017297 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 460265017298 substrate binding site; other site 460265017299 dimer interface; other site 460265017300 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 460265017301 homotrimer interaction site [polypeptide binding]; other site 460265017302 zinc binding site [ion binding]; other site 460265017303 CDP-binding sites; other site 460265017304 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 460265017305 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 460265017306 FMN binding site [chemical binding]; other site 460265017307 active site 460265017308 catalytic residues [active] 460265017309 substrate binding site [chemical binding]; other site 460265017310 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 460265017311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265017312 dimer interface [polypeptide binding]; other site 460265017313 phosphorylation site [posttranslational modification] 460265017314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265017315 ATP binding site [chemical binding]; other site 460265017316 Mg2+ binding site [ion binding]; other site 460265017317 G-X-G motif; other site 460265017318 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 460265017319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265017320 active site 460265017321 phosphorylation site [posttranslational modification] 460265017322 intermolecular recognition site; other site 460265017323 dimerization interface [polypeptide binding]; other site 460265017324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265017325 Walker A motif; other site 460265017326 ATP binding site [chemical binding]; other site 460265017327 Walker B motif; other site 460265017328 arginine finger; other site 460265017329 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 460265017330 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265017331 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 460265017332 dimerization interface [polypeptide binding]; other site 460265017333 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 460265017334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265017335 putative active site [active] 460265017336 heme pocket [chemical binding]; other site 460265017337 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265017338 dimer interface [polypeptide binding]; other site 460265017339 phosphorylation site [posttranslational modification] 460265017340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265017341 ATP binding site [chemical binding]; other site 460265017342 Mg2+ binding site [ion binding]; other site 460265017343 G-X-G motif; other site 460265017344 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 460265017345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265017346 active site 460265017347 phosphorylation site [posttranslational modification] 460265017348 intermolecular recognition site; other site 460265017349 dimerization interface [polypeptide binding]; other site 460265017350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265017351 Walker A motif; other site 460265017352 ATP binding site [chemical binding]; other site 460265017353 Walker B motif; other site 460265017354 arginine finger; other site 460265017355 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 460265017356 bacterial Hfq-like; Region: Hfq; cd01716 460265017357 hexamer interface [polypeptide binding]; other site 460265017358 Sm1 motif; other site 460265017359 RNA binding site [nucleotide binding]; other site 460265017360 Sm2 motif; other site 460265017361 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 460265017362 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 460265017363 HflX GTPase family; Region: HflX; cd01878 460265017364 G1 box; other site 460265017365 GTP/Mg2+ binding site [chemical binding]; other site 460265017366 Switch I region; other site 460265017367 G2 box; other site 460265017368 G3 box; other site 460265017369 Switch II region; other site 460265017370 G4 box; other site 460265017371 G5 box; other site 460265017372 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 460265017373 putative heme binding pocket [chemical binding]; other site 460265017374 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 460265017375 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 460265017376 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 460265017377 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 460265017378 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 460265017379 homodimer interface [polypeptide binding]; other site 460265017380 metal binding site [ion binding]; metal-binding site 460265017381 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 460265017382 homodimer interface [polypeptide binding]; other site 460265017383 active site 460265017384 putative chemical substrate binding site [chemical binding]; other site 460265017385 metal binding site [ion binding]; metal-binding site 460265017386 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 460265017387 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 460265017388 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 460265017389 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 460265017390 Catalytic site [active] 460265017391 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 460265017392 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 460265017393 heterodimer interface [polypeptide binding]; other site 460265017394 homodimer interface [polypeptide binding]; other site 460265017395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 460265017396 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 460265017397 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 460265017398 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 460265017399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 460265017400 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 460265017401 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 460265017402 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 460265017403 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 460265017404 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 460265017405 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 460265017406 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 460265017407 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 460265017408 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 460265017409 NlpC/P60 family; Region: NLPC_P60; cl17555 460265017410 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 460265017411 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 460265017412 Putative phage tail protein; Region: Phage-tail_3; pfam13550 460265017413 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 460265017414 Catalytic domain of bacteriophage endosialidase; Region: End_tail_spike; pfam12219 460265017415 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 460265017416 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 460265017417 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 460265017418 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 460265017419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 460265017420 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 460265017421 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265017422 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 460265017423 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 460265017424 active site 460265017425 catalytic site [active] 460265017426 substrate binding site [chemical binding]; other site 460265017427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265017428 metabolite-proton symporter; Region: 2A0106; TIGR00883 460265017429 putative substrate translocation pore; other site 460265017430 galactarate dehydratase; Region: galactar-dH20; TIGR03248 460265017431 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 460265017432 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 460265017433 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 460265017434 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 460265017435 Walker A/P-loop; other site 460265017436 ATP binding site [chemical binding]; other site 460265017437 Q-loop/lid; other site 460265017438 ABC transporter signature motif; other site 460265017439 Walker B; other site 460265017440 D-loop; other site 460265017441 H-loop/switch region; other site 460265017442 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 460265017443 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 460265017444 TM-ABC transporter signature motif; other site 460265017445 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 460265017446 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 460265017447 Walker A/P-loop; other site 460265017448 ATP binding site [chemical binding]; other site 460265017449 Q-loop/lid; other site 460265017450 ABC transporter signature motif; other site 460265017451 Walker B; other site 460265017452 D-loop; other site 460265017453 H-loop/switch region; other site 460265017454 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 460265017455 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 460265017456 TM-ABC transporter signature motif; other site 460265017457 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 460265017458 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 460265017459 ligand binding site [chemical binding]; other site 460265017460 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 460265017461 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 460265017462 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 460265017463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265017464 S-adenosylmethionine binding site [chemical binding]; other site 460265017465 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 460265017466 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 460265017467 RNA binding surface [nucleotide binding]; other site 460265017468 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 460265017469 active site 460265017470 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 460265017471 nucleoside/Zn binding site; other site 460265017472 dimer interface [polypeptide binding]; other site 460265017473 catalytic motif [active] 460265017474 manganese transport protein MntH; Reviewed; Region: PRK00701 460265017475 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 460265017476 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 460265017477 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 460265017478 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 460265017479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 460265017480 Coenzyme A binding pocket [chemical binding]; other site 460265017481 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 460265017482 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 460265017483 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 460265017484 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 460265017485 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 460265017486 Coproporphyrinogen III oxidase [Coenzyme metabolism]; Region: HemF; COG0408 460265017487 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 460265017488 EamA-like transporter family; Region: EamA; cl17759 460265017489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 460265017490 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 460265017491 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 460265017492 catalytic loop [active] 460265017493 iron binding site [ion binding]; other site 460265017494 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 460265017495 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 460265017496 generic binding surface II; other site 460265017497 generic binding surface I; other site 460265017498 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 460265017499 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265017500 catalytic loop [active] 460265017501 iron binding site [ion binding]; other site 460265017502 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 460265017503 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 460265017504 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265017505 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 460265017506 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265017507 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 460265017508 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 460265017509 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 460265017510 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 460265017511 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 460265017512 active site 460265017513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 460265017514 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 460265017515 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 460265017516 RNA binding site [nucleotide binding]; other site 460265017517 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 460265017518 RNA binding site [nucleotide binding]; other site 460265017519 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 460265017520 RNA binding site [nucleotide binding]; other site 460265017521 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 460265017522 RNA binding site [nucleotide binding]; other site 460265017523 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 460265017524 RNA binding site [nucleotide binding]; other site 460265017525 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 460265017526 RNA binding site [nucleotide binding]; other site 460265017527 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 460265017528 putative active site [active] 460265017529 putative metal binding residues [ion binding]; other site 460265017530 signature motif; other site 460265017531 putative dimer interface [polypeptide binding]; other site 460265017532 putative phosphate binding site [ion binding]; other site 460265017533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265017534 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 460265017535 putative active site [active] 460265017536 heme pocket [chemical binding]; other site 460265017537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265017538 putative active site [active] 460265017539 heme pocket [chemical binding]; other site 460265017540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265017541 dimer interface [polypeptide binding]; other site 460265017542 phosphorylation site [posttranslational modification] 460265017543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265017544 ATP binding site [chemical binding]; other site 460265017545 G-X-G motif; other site 460265017546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265017547 active site 460265017548 phosphorylation site [posttranslational modification] 460265017549 intermolecular recognition site; other site 460265017550 dimerization interface [polypeptide binding]; other site 460265017551 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 460265017552 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 460265017553 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 460265017554 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 460265017555 Transcriptional regulator [Transcription]; Region: IclR; COG1414 460265017556 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 460265017557 Bacterial transcriptional regulator; Region: IclR; pfam01614 460265017558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265017559 putative substrate translocation pore; other site 460265017560 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 460265017561 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 460265017562 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 460265017563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265017564 NAD(P) binding site [chemical binding]; other site 460265017565 active site 460265017566 L-rhamnonate dehydratase; Provisional; Region: PRK15440 460265017567 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 460265017568 putative active site pocket [active] 460265017569 putative metal binding site [ion binding]; other site 460265017570 CopC domain; Region: CopC; pfam04234 460265017571 Copper resistance protein D; Region: CopD; pfam05425 460265017572 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 460265017573 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 460265017574 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 460265017575 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 460265017576 Predicted transcriptional regulators [Transcription]; Region: COG1733 460265017577 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 460265017578 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265017579 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265017580 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 460265017581 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 460265017582 nudix motif; other site 460265017583 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 460265017584 Domain of unknown function DUF20; Region: UPF0118; pfam01594 460265017585 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 460265017586 GAF domain; Region: GAF; pfam01590 460265017587 PAS domain; Region: PAS_9; pfam13426 460265017588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265017589 putative active site [active] 460265017590 heme pocket [chemical binding]; other site 460265017591 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265017592 PAS fold; Region: PAS_3; pfam08447 460265017593 putative active site [active] 460265017594 heme pocket [chemical binding]; other site 460265017595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 460265017596 Histidine kinase; Region: HisKA_2; pfam07568 460265017597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265017598 ATP binding site [chemical binding]; other site 460265017599 Mg2+ binding site [ion binding]; other site 460265017600 G-X-G motif; other site 460265017601 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 460265017602 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 460265017603 Domain of unknown function (DUF303); Region: DUF303; pfam03629 460265017604 Bacteriophage lambda tail assembly protein I; Region: Lambda_tail_I; cl01945 460265017605 Phage-related protein, tail component [Function unknown]; Region: COG4733 460265017606 Putative phage tail protein; Region: Phage-tail_3; pfam13550 460265017607 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 460265017608 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 460265017609 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 460265017610 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 460265017611 YcfA-like protein; Region: YcfA; pfam07927 460265017612 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 460265017613 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 460265017614 transcriptional activator RfaH; Region: RfaH; TIGR01955 460265017615 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 460265017616 heterodimer interface [polypeptide binding]; other site 460265017617 homodimer interface [polypeptide binding]; other site 460265017618 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 460265017619 polymerase nucleotide-binding site; other site 460265017620 DNA-binding residues [nucleotide binding]; DNA binding site 460265017621 nucleotide binding site [chemical binding]; other site 460265017622 primase nucleotide-binding site [nucleotide binding]; other site 460265017623 Domain of unknown function (DUF329); Region: DUF329; cl01144 460265017624 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 460265017625 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 460265017626 putative ion selectivity filter; other site 460265017627 putative pore gating glutamate residue; other site 460265017628 putative H+/Cl- coupling transport residue; other site 460265017629 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 460265017630 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 460265017631 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 460265017632 Protein of unknown function (DUF563); Region: DUF563; pfam04577 460265017633 peptide deformylase; Reviewed; Region: PRK12846 460265017634 active site 460265017635 catalytic residues [active] 460265017636 metal binding site [ion binding]; metal-binding site 460265017637 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 460265017638 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 460265017639 inhibitor site; inhibition site 460265017640 active site 460265017641 dimer interface [polypeptide binding]; other site 460265017642 catalytic residue [active] 460265017643 LysE type translocator; Region: LysE; cl00565 460265017644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 460265017645 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 460265017646 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 460265017647 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 460265017648 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 460265017649 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 460265017650 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 460265017651 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 460265017652 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 460265017653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 460265017654 motif II; other site 460265017655 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 460265017656 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 460265017657 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 460265017658 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 460265017659 NAD(P) binding pocket [chemical binding]; other site 460265017660 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 460265017661 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 460265017662 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265017663 substrate binding pocket [chemical binding]; other site 460265017664 membrane-bound complex binding site; other site 460265017665 hinge residues; other site 460265017666 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 460265017667 putative CheW interface [polypeptide binding]; other site 460265017668 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 460265017669 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265017670 FeS/SAM binding site; other site 460265017671 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 460265017672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 460265017673 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 460265017674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265017675 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 460265017676 putative active site [active] 460265017677 heme pocket [chemical binding]; other site 460265017678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265017679 putative active site [active] 460265017680 heme pocket [chemical binding]; other site 460265017681 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265017682 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265017683 DNA binding residues [nucleotide binding] 460265017684 dimerization interface [polypeptide binding]; other site 460265017685 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 460265017686 GAF domain; Region: GAF; pfam01590 460265017687 polyubiquitin binding domain of NEMO and related proteins; Region: UBAN; cd09803 460265017688 polyubiquitin binding site [polypeptide binding]; other site 460265017689 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 460265017690 Histidine kinase; Region: HisKA_2; pfam07568 460265017691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265017692 ATP binding site [chemical binding]; other site 460265017693 Mg2+ binding site [ion binding]; other site 460265017694 G-X-G motif; other site 460265017695 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 460265017696 EcsC protein family; Region: EcsC; pfam12787 460265017697 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 460265017698 GSH binding site (G-site) [chemical binding]; other site 460265017699 C-terminal domain interface [polypeptide binding]; other site 460265017700 dimer interface [polypeptide binding]; other site 460265017701 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 460265017702 dimer interface [polypeptide binding]; other site 460265017703 N-terminal domain interface [polypeptide binding]; other site 460265017704 substrate binding pocket (H-site) [chemical binding]; other site 460265017705 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 460265017706 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 460265017707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265017708 NAD(P) binding site [chemical binding]; other site 460265017709 active site 460265017710 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 460265017711 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 460265017712 acyl-activating enzyme (AAE) consensus motif; other site 460265017713 AMP binding site [chemical binding]; other site 460265017714 active site 460265017715 CoA binding site [chemical binding]; other site 460265017716 thiamine pyrophosphate protein; Validated; Region: PRK08199 460265017717 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 460265017718 PYR/PP interface [polypeptide binding]; other site 460265017719 dimer interface [polypeptide binding]; other site 460265017720 TPP binding site [chemical binding]; other site 460265017721 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 460265017722 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 460265017723 TPP-binding site [chemical binding]; other site 460265017724 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 460265017725 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 460265017726 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 460265017727 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 460265017728 SnoaL-like domain; Region: SnoaL_2; pfam12680 460265017729 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 460265017730 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 460265017731 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 460265017732 metal ion-dependent adhesion site (MIDAS); other site 460265017733 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 460265017734 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 460265017735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 460265017736 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 460265017737 HSP70 interaction site [polypeptide binding]; other site 460265017738 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 460265017739 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 460265017740 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 460265017741 active site 460265017742 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 460265017743 Ligand Binding Site [chemical binding]; other site 460265017744 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 460265017745 active site 460265017746 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 460265017747 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 460265017748 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 460265017749 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 460265017750 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 460265017751 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 460265017752 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 460265017753 active site 460265017754 metal binding site [ion binding]; metal-binding site 460265017755 hexamer interface [polypeptide binding]; other site 460265017756 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 460265017757 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 460265017758 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 460265017759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265017760 dimer interface [polypeptide binding]; other site 460265017761 conserved gate region; other site 460265017762 putative PBP binding loops; other site 460265017763 ABC-ATPase subunit interface; other site 460265017764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265017765 putative PBP binding loops; other site 460265017766 ABC-ATPase subunit interface; other site 460265017767 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 460265017768 Cytochrome P450; Region: p450; cl12078 460265017769 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 460265017770 Protein of unknown function (DUF808); Region: DUF808; cl01002 460265017771 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 460265017772 short chain dehydrogenase; Provisional; Region: PRK06197 460265017773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265017774 NAD(P) binding site [chemical binding]; other site 460265017775 active site 460265017776 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 460265017777 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 460265017778 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 460265017779 ABC transporter; Region: ABC_tran_2; pfam12848 460265017780 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 460265017781 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 460265017782 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 460265017783 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 460265017784 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 460265017785 EamA-like transporter family; Region: EamA; pfam00892 460265017786 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 460265017787 EamA-like transporter family; Region: EamA; pfam00892 460265017788 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 460265017789 MgtC family; Region: MgtC; pfam02308 460265017790 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265017791 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265017792 ligand binding site [chemical binding]; other site 460265017793 flexible hinge region; other site 460265017794 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 460265017795 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265017796 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265017797 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 460265017798 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 460265017799 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265017800 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265017801 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 460265017802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265017803 putative substrate translocation pore; other site 460265017804 Uncharacterized conserved protein [Function unknown]; Region: COG4274 460265017805 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 460265017806 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265017807 Walker A/P-loop; other site 460265017808 ATP binding site [chemical binding]; other site 460265017809 Q-loop/lid; other site 460265017810 ABC transporter signature motif; other site 460265017811 Walker B; other site 460265017812 D-loop; other site 460265017813 H-loop/switch region; other site 460265017814 TOBE domain; Region: TOBE_2; pfam08402 460265017815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265017816 dimer interface [polypeptide binding]; other site 460265017817 conserved gate region; other site 460265017818 putative PBP binding loops; other site 460265017819 ABC-ATPase subunit interface; other site 460265017820 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 460265017821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265017822 dimer interface [polypeptide binding]; other site 460265017823 conserved gate region; other site 460265017824 putative PBP binding loops; other site 460265017825 ABC-ATPase subunit interface; other site 460265017826 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 460265017827 Protein of unknown function (DUF497); Region: DUF497; pfam04365 460265017828 Family of unknown function (DUF490); Region: DUF490; pfam04357 460265017829 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 460265017830 Surface antigen; Region: Bac_surface_Ag; pfam01103 460265017831 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 460265017832 putative active site [active] 460265017833 Zn binding site [ion binding]; other site 460265017834 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 460265017835 interface (dimer of trimers) [polypeptide binding]; other site 460265017836 Substrate-binding/catalytic site; other site 460265017837 Zn-binding sites [ion binding]; other site 460265017838 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 460265017839 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 460265017840 substrate binding pocket [chemical binding]; other site 460265017841 membrane-bound complex binding site; other site 460265017842 hinge residues; other site 460265017843 hypothetical protein; Validated; Region: PRK06201 460265017844 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 460265017845 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 460265017846 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 460265017847 catalytic site [active] 460265017848 Uncharacterized conserved protein [Function unknown]; Region: COG3777 460265017849 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 460265017850 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 460265017851 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 460265017852 CoA-transferase family III; Region: CoA_transf_3; pfam02515 460265017853 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 460265017854 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 460265017855 active site 460265017856 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 460265017857 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 460265017858 NAD(P) binding site [chemical binding]; other site 460265017859 catalytic residues [active] 460265017860 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 460265017861 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 460265017862 TPP-binding site [chemical binding]; other site 460265017863 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 460265017864 PYR/PP interface [polypeptide binding]; other site 460265017865 dimer interface [polypeptide binding]; other site 460265017866 TPP binding site [chemical binding]; other site 460265017867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265017868 metabolite-proton symporter; Region: 2A0106; TIGR00883 460265017869 putative substrate translocation pore; other site 460265017870 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265017871 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265017872 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 460265017873 putative dimerization interface [polypeptide binding]; other site 460265017874 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 460265017875 active site 460265017876 TDP-binding site; other site 460265017877 acceptor substrate-binding pocket; other site 460265017878 Tetratricopeptide repeat; Region: TPR_12; pfam13424 460265017879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265017880 TPR motif; other site 460265017881 binding surface 460265017882 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 460265017883 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 460265017884 TPP-binding site; other site 460265017885 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 460265017886 PYR/PP interface [polypeptide binding]; other site 460265017887 dimer interface [polypeptide binding]; other site 460265017888 TPP binding site [chemical binding]; other site 460265017889 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 460265017890 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 460265017891 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 460265017892 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 460265017893 ligand binding site [chemical binding]; other site 460265017894 NAD binding site [chemical binding]; other site 460265017895 dimerization interface [polypeptide binding]; other site 460265017896 catalytic site [active] 460265017897 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 460265017898 putative L-serine binding site [chemical binding]; other site 460265017899 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 460265017900 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 460265017901 catalytic residue [active] 460265017902 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 460265017903 FAD binding domain; Region: FAD_binding_3; pfam01494 460265017904 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265017905 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265017906 Predicted transcriptional regulator [Transcription]; Region: COG2378 460265017907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265017908 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265017909 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265017910 multiple promoter invertase; Provisional; Region: mpi; PRK13413 460265017911 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 460265017912 catalytic residues [active] 460265017913 catalytic nucleophile [active] 460265017914 Presynaptic Site I dimer interface [polypeptide binding]; other site 460265017915 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 460265017916 Synaptic Flat tetramer interface [polypeptide binding]; other site 460265017917 Synaptic Site I dimer interface [polypeptide binding]; other site 460265017918 DNA binding site [nucleotide binding] 460265017919 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 460265017920 DNA-binding interface [nucleotide binding]; DNA binding site 460265017921 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 460265017922 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 460265017923 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 460265017924 Predicted membrane protein [Function unknown]; Region: COG1238 460265017925 Transposase; Region: HTH_Tnp_1; cl17663 460265017926 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 460265017927 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 460265017928 active site 460265017929 Int/Topo IB signature motif; other site 460265017930 DNA binding site [nucleotide binding] 460265017931 Domain of unknown function (DUF329); Region: DUF329; cl01144 460265017932 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 460265017933 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265017934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265017935 active site 460265017936 phosphorylation site [posttranslational modification] 460265017937 intermolecular recognition site; other site 460265017938 dimerization interface [polypeptide binding]; other site 460265017939 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265017940 DNA binding residues [nucleotide binding] 460265017941 dimerization interface [polypeptide binding]; other site 460265017942 Winged helix-turn helix; Region: HTH_29; pfam13551 460265017943 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265017944 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 460265017945 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265017946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 460265017947 HTH-like domain; Region: HTH_21; pfam13276 460265017948 Integrase core domain; Region: rve; pfam00665 460265017949 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 460265017950 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 460265017951 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 460265017952 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265017953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265017954 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 460265017955 putative dimerization interface [polypeptide binding]; other site 460265017956 Predicted permeases [General function prediction only]; Region: COG0679 460265017957 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 460265017958 active site 2 [active] 460265017959 active site 1 [active] 460265017960 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 460265017961 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 460265017962 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 460265017963 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 460265017964 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 460265017965 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 460265017966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265017967 DNA-binding site [nucleotide binding]; DNA binding site 460265017968 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 460265017969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265017970 homodimer interface [polypeptide binding]; other site 460265017971 catalytic residue [active] 460265017972 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 460265017973 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 460265017974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 460265017975 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 460265017976 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 460265017977 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 460265017978 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 460265017979 active site 460265017980 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 460265017981 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 460265017982 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 460265017983 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 460265017984 ATP-grasp domain; Region: ATP-grasp_4; cl17255 460265017985 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 460265017986 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 460265017987 SLBB domain; Region: SLBB; pfam10531 460265017988 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 460265017989 Methyltransferase domain; Region: Methyltransf_31; pfam13847 460265017990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265017991 S-adenosylmethionine binding site [chemical binding]; other site 460265017992 Methyltransferase domain; Region: Methyltransf_23; pfam13489 460265017993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265017994 S-adenosylmethionine binding site [chemical binding]; other site 460265017995 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 460265017996 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 460265017997 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265017998 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 460265017999 Protein of unknown function (DUF1616); Region: DUF1616; cl01959 460265018000 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265018001 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 460265018002 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 460265018003 Ligand binding site; other site 460265018004 Putative Catalytic site; other site 460265018005 DXD motif; other site 460265018006 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 460265018007 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 460265018008 Methyltransferase domain; Region: Methyltransf_23; pfam13489 460265018009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265018010 S-adenosylmethionine binding site [chemical binding]; other site 460265018011 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265018012 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 460265018013 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 460265018014 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 460265018015 putative molybdopterin cofactor binding site [chemical binding]; other site 460265018016 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 460265018017 putative molybdopterin cofactor binding site; other site 460265018018 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 460265018019 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 460265018020 Subunit I/III interface [polypeptide binding]; other site 460265018021 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 460265018022 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 460265018023 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 460265018024 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 460265018025 Cytochrome c; Region: Cytochrom_C; pfam00034 460265018026 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 460265018027 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 460265018028 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 460265018029 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 460265018030 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 460265018031 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 460265018032 molybdopterin cofactor binding site; other site 460265018033 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 460265018034 4Fe-4S binding domain; Region: Fer4; pfam00037 460265018035 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 460265018036 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 460265018037 heme-binding residues [chemical binding]; other site 460265018038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265018039 S-adenosylmethionine binding site [chemical binding]; other site 460265018040 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 460265018041 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 460265018042 Uncharacterized conserved protein [Function unknown]; Region: COG1359 460265018043 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 460265018044 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 460265018045 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 460265018046 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 460265018047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265018048 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 460265018049 dimerization interface [polypeptide binding]; other site 460265018050 substrate binding pocket [chemical binding]; other site 460265018051 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 460265018052 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 460265018053 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 460265018054 DctM-like transporters; Region: DctM; pfam06808 460265018055 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 460265018056 Hemerythrin-like domain; Region: Hr-like; cd12108 460265018057 Fe binding site [ion binding]; other site 460265018058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265018059 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265018060 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265018061 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 460265018062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 460265018063 Coenzyme A binding pocket [chemical binding]; other site 460265018064 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 460265018065 propionate/acetate kinase; Provisional; Region: PRK12379 460265018066 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 460265018067 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 460265018068 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 460265018069 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 460265018070 NAD binding site [chemical binding]; other site 460265018071 homotetramer interface [polypeptide binding]; other site 460265018072 homodimer interface [polypeptide binding]; other site 460265018073 substrate binding site [chemical binding]; other site 460265018074 active site 460265018075 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14736 460265018076 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 460265018077 gamma subunit interface [polypeptide binding]; other site 460265018078 epsilon subunit interface [polypeptide binding]; other site 460265018079 LBP interface [polypeptide binding]; other site 460265018080 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 460265018081 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 460265018082 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 460265018083 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 460265018084 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265018085 nif11 domain/cupin domain protein; Region: nif11_cupin; TIGR03890 460265018086 putative hydrolase; Provisional; Region: PRK02113 460265018087 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 460265018088 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 460265018089 active site 460265018090 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 460265018091 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 460265018092 active site 460265018093 HIGH motif; other site 460265018094 KMSKS motif; other site 460265018095 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 460265018096 tRNA binding surface [nucleotide binding]; other site 460265018097 anticodon binding site; other site 460265018098 DNA polymerase III subunit delta'; Validated; Region: PRK07471 460265018099 DNA polymerase III subunit delta'; Validated; Region: PRK08485 460265018100 thymidylate kinase; Region: DTMP_kinase; TIGR00041 460265018101 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 460265018102 TMP-binding site; other site 460265018103 ATP-binding site [chemical binding]; other site 460265018104 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 460265018105 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 460265018106 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 460265018107 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 460265018108 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 460265018109 Domain of unknown function (DUF336); Region: DUF336; pfam03928 460265018110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265018111 S-adenosylmethionine binding site [chemical binding]; other site 460265018112 chaperone protein DnaJ; Provisional; Region: PRK10767 460265018113 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 460265018114 HSP70 interaction site [polypeptide binding]; other site 460265018115 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 460265018116 substrate binding site [polypeptide binding]; other site 460265018117 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 460265018118 Zn binding sites [ion binding]; other site 460265018119 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 460265018120 dimer interface [polypeptide binding]; other site 460265018121 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 460265018122 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 460265018123 nucleotide binding site [chemical binding]; other site 460265018124 NEF interaction site [polypeptide binding]; other site 460265018125 SBD interface [polypeptide binding]; other site 460265018126 hypothetical protein; Validated; Region: PRK00228 460265018127 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 460265018128 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 460265018129 catalytic triad [active] 460265018130 dimer interface [polypeptide binding]; other site 460265018131 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 460265018132 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 460265018133 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265018134 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 460265018135 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 460265018136 phosphoglycolate phosphatase; Provisional; Region: PRK13222 460265018137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 460265018138 motif II; other site 460265018139 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 460265018140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 460265018141 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 460265018142 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265018143 DNA-binding site [nucleotide binding]; DNA binding site 460265018144 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 460265018145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265018146 homodimer interface [polypeptide binding]; other site 460265018147 catalytic residue [active] 460265018148 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 460265018149 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 460265018150 dimer interface [polypeptide binding]; other site 460265018151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265018152 catalytic residue [active] 460265018153 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 460265018154 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 460265018155 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 460265018156 IucA / IucC family; Region: IucA_IucC; pfam04183 460265018157 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 460265018158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265018159 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 460265018160 IucA / IucC family; Region: IucA_IucC; pfam04183 460265018161 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 460265018162 IucA / IucC family; Region: IucA_IucC; pfam04183 460265018163 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 460265018164 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 460265018165 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 460265018166 dimer interface [polypeptide binding]; other site 460265018167 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 460265018168 active site 460265018169 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 460265018170 catalytic residues [active] 460265018171 substrate binding site [chemical binding]; other site 460265018172 ParB-like nuclease domain; Region: ParB; smart00470 460265018173 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265018174 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265018175 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265018176 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265018177 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 460265018178 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 460265018179 N-terminal plug; other site 460265018180 ligand-binding site [chemical binding]; other site 460265018181 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 460265018182 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 460265018183 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 460265018184 catalytic residue [active] 460265018185 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 460265018186 active site 460265018187 DNA binding site [nucleotide binding] 460265018188 Int/Topo IB signature motif; other site 460265018189 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 460265018190 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 460265018191 DNA binding site [nucleotide binding] 460265018192 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 460265018193 RecT family; Region: RecT; cl04285 460265018194 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 460265018195 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265018196 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 460265018197 non-specific DNA binding site [nucleotide binding]; other site 460265018198 salt bridge; other site 460265018199 sequence-specific DNA binding site [nucleotide binding]; other site 460265018200 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 460265018201 non-specific DNA binding site [nucleotide binding]; other site 460265018202 salt bridge; other site 460265018203 sequence-specific DNA binding site [nucleotide binding]; other site 460265018204 replicative DNA helicase; Region: DnaB; TIGR00665 460265018205 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 460265018206 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 460265018207 Walker A motif; other site 460265018208 ATP binding site [chemical binding]; other site 460265018209 Walker B motif; other site 460265018210 Transcription antiterminator [Transcription]; Region: NusG; COG0250 460265018211 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 460265018212 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 460265018213 heterodimer interface [polypeptide binding]; other site 460265018214 homodimer interface [polypeptide binding]; other site 460265018215 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 460265018216 ParB-like nuclease domain; Region: ParBc; pfam02195 460265018217 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 460265018218 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 460265018219 cofactor binding site; other site 460265018220 DNA binding site [nucleotide binding] 460265018221 substrate interaction site [chemical binding]; other site 460265018222 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 460265018223 active site 460265018224 dimer interface [polypeptide binding]; other site 460265018225 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 460265018226 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 460265018227 Ligand Binding Site [chemical binding]; other site 460265018228 Molecular Tunnel; other site 460265018229 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 460265018230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 460265018231 S-adenosylmethionine binding site [chemical binding]; other site 460265018232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 460265018233 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 460265018234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567 460265018235 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 460265018236 hypothetical protein; Provisional; Region: 57B; PHA02574 460265018237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566 460265018238 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 460265018239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 460265018240 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 460265018241 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 460265018242 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 460265018243 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 460265018244 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 460265018245 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 460265018246 Phage-related minor tail protein [Function unknown]; Region: COG5281 460265018247 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265018248 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265018249 catalytic residue [active] 460265018250 Phage minor tail protein; Region: Phage_min_tail; cl01940 460265018251 Phage minor tail protein L; Region: Phage_tail_L; cl01908 460265018252 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 460265018253 MPN+ (JAMM) motif; other site 460265018254 Zinc-binding site [ion binding]; other site 460265018255 Phage-related protein, tail component [Function unknown]; Region: COG4723 460265018256 Phage-related protein, tail component [Function unknown]; Region: COG4733 460265018257 Putative phage tail protein; Region: Phage-tail_3; pfam13550 460265018258 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 460265018259 Interdomain contacts; other site 460265018260 Cytokine receptor motif; other site 460265018261 Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795 460265018262 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 460265018263 Transposase domain (DUF772); Region: DUF772; pfam05598 460265018264 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265018265 WxcM-like, C-terminal; Region: FdtA; pfam05523 460265018266 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 460265018267 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 460265018268 inhibitor-cofactor binding pocket; inhibition site 460265018269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265018270 catalytic residue [active] 460265018271 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 460265018272 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 460265018273 putative trimer interface [polypeptide binding]; other site 460265018274 putative CoA binding site [chemical binding]; other site 460265018275 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 460265018276 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 460265018277 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 460265018278 active site 460265018279 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 460265018280 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 460265018281 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 460265018282 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265018283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265018284 active site 460265018285 phosphorylation site [posttranslational modification] 460265018286 intermolecular recognition site; other site 460265018287 dimerization interface [polypeptide binding]; other site 460265018288 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 460265018289 non-specific DNA binding site [nucleotide binding]; other site 460265018290 salt bridge; other site 460265018291 sequence-specific DNA binding site [nucleotide binding]; other site 460265018292 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 460265018293 Catalytic site [active] 460265018294 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 460265018295 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 460265018296 active site 460265018297 DNA binding site [nucleotide binding] 460265018298 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 460265018299 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 460265018300 additional DNA contacts [nucleotide binding]; other site 460265018301 mismatch recognition site; other site 460265018302 active site 460265018303 zinc binding site [ion binding]; other site 460265018304 DNA intercalation site [nucleotide binding]; other site 460265018305 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 460265018306 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 460265018307 cofactor binding site; other site 460265018308 DNA binding site [nucleotide binding] 460265018309 substrate interaction site [chemical binding]; other site 460265018310 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 460265018311 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 460265018312 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 460265018313 active site 460265018314 Int/Topo IB signature motif; other site 460265018315 Uncharacterized conserved protein [Function unknown]; Region: COG2928 460265018316 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 460265018317 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 460265018318 DNA binding site [nucleotide binding] 460265018319 catalytic residue [active] 460265018320 H2TH interface [polypeptide binding]; other site 460265018321 putative catalytic residues [active] 460265018322 turnover-facilitating residue; other site 460265018323 intercalation triad [nucleotide binding]; other site 460265018324 8OG recognition residue [nucleotide binding]; other site 460265018325 putative reading head residues; other site 460265018326 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 460265018327 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 460265018328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265018329 S-adenosylmethionine binding site [chemical binding]; other site 460265018330 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 460265018331 ABC1 family; Region: ABC1; cl17513 460265018332 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 460265018333 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 460265018334 putative ligand binding site [chemical binding]; other site 460265018335 Helix-turn-helix domain; Region: HTH_37; pfam13744 460265018336 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 460265018337 Flavoprotein; Region: Flavoprotein; pfam02441 460265018338 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 460265018339 HerA helicase [Replication, recombination, and repair]; Region: COG0433 460265018340 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 460265018341 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 460265018342 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 460265018343 putative N-terminal domain interface [polypeptide binding]; other site 460265018344 putative dimer interface [polypeptide binding]; other site 460265018345 putative substrate binding pocket (H-site) [chemical binding]; other site 460265018346 L-lactate permease; Region: Lactate_perm; cl00701 460265018347 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 460265018348 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 460265018349 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 460265018350 SpoVR family protein; Provisional; Region: PRK11767 460265018351 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 460265018352 hypothetical protein; Provisional; Region: PRK05325 460265018353 PrkA family serine protein kinase; Provisional; Region: PRK15455 460265018354 AAA ATPase domain; Region: AAA_16; pfam13191 460265018355 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 460265018356 HD domain; Region: HD_4; pfam13328 460265018357 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 460265018358 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 460265018359 DNA binding residues [nucleotide binding] 460265018360 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 460265018361 IHF dimer interface [polypeptide binding]; other site 460265018362 IHF - DNA interface [nucleotide binding]; other site 460265018363 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 460265018364 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 460265018365 dimer interface [polypeptide binding]; other site 460265018366 active site 460265018367 CoA binding pocket [chemical binding]; other site 460265018368 putative phosphate acyltransferase; Provisional; Region: PRK05331 460265018369 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 460265018370 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 460265018371 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 460265018372 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 460265018373 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 460265018374 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 460265018375 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 460265018376 Walker A/P-loop; other site 460265018377 ATP binding site [chemical binding]; other site 460265018378 Q-loop/lid; other site 460265018379 ABC transporter signature motif; other site 460265018380 Walker B; other site 460265018381 D-loop; other site 460265018382 H-loop/switch region; other site 460265018383 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 460265018384 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 460265018385 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 460265018386 active site 460265018387 catalytic tetrad [active] 460265018388 Helix-turn-helix domain; Region: HTH_18; pfam12833 460265018389 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265018390 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 460265018391 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 460265018392 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 460265018393 Domain of unknown function (DUF697); Region: DUF697; cl12064 460265018394 YcjX-like family, DUF463; Region: DUF463; pfam04317 460265018395 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 460265018396 catalytic core [active] 460265018397 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 460265018398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265018399 Walker A motif; other site 460265018400 ATP binding site [chemical binding]; other site 460265018401 Walker B motif; other site 460265018402 arginine finger; other site 460265018403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265018404 active site 460265018405 phosphorylation site [posttranslational modification] 460265018406 intermolecular recognition site; other site 460265018407 dimerization interface [polypeptide binding]; other site 460265018408 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 460265018409 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 460265018410 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 460265018411 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 460265018412 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 460265018413 active site 460265018414 tetramer interface [polypeptide binding]; other site 460265018415 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 460265018416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265018417 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 460265018418 putative dimerization interface [polypeptide binding]; other site 460265018419 putative substrate binding pocket [chemical binding]; other site 460265018420 1-deoxy-D-xylulose-5-phosphate synthase; Region: PLN02234 460265018421 muropeptide transporter; Reviewed; Region: ampG; PRK11902 460265018422 muropeptide transporter; Validated; Region: ampG; cl17669 460265018423 hypothetical protein; Provisional; Region: PRK13559 460265018424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 460265018425 putative active site [active] 460265018426 heme pocket [chemical binding]; other site 460265018427 Histidine kinase; Region: HisKA_2; pfam07568 460265018428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265018429 ATP binding site [chemical binding]; other site 460265018430 Mg2+ binding site [ion binding]; other site 460265018431 G-X-G motif; other site 460265018432 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 460265018433 MutS domain I; Region: MutS_I; pfam01624 460265018434 MutS domain II; Region: MutS_II; pfam05188 460265018435 MutS domain III; Region: MutS_III; pfam05192 460265018436 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 460265018437 Walker A/P-loop; other site 460265018438 ATP binding site [chemical binding]; other site 460265018439 Q-loop/lid; other site 460265018440 ABC transporter signature motif; other site 460265018441 Walker B; other site 460265018442 D-loop; other site 460265018443 H-loop/switch region; other site 460265018444 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 460265018445 Malic enzyme, N-terminal domain; Region: malic; pfam00390 460265018446 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 460265018447 putative NAD(P) binding site [chemical binding]; other site 460265018448 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 460265018449 benzoate transport; Region: 2A0115; TIGR00895 460265018450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265018451 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 460265018452 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 460265018453 FMN-binding pocket [chemical binding]; other site 460265018454 flavin binding motif; other site 460265018455 phosphate binding motif [ion binding]; other site 460265018456 beta-alpha-beta structure motif; other site 460265018457 NAD binding pocket [chemical binding]; other site 460265018458 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265018459 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 460265018460 catalytic loop [active] 460265018461 iron binding site [ion binding]; other site 460265018462 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 460265018463 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 460265018464 iron-sulfur cluster [ion binding]; other site 460265018465 [2Fe-2S] cluster binding site [ion binding]; other site 460265018466 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 460265018467 alpha subunit interface [polypeptide binding]; other site 460265018468 active site 460265018469 substrate binding site [chemical binding]; other site 460265018470 Fe binding site [ion binding]; other site 460265018471 Helix-turn-helix domain; Region: HTH_18; pfam12833 460265018472 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265018473 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 460265018474 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 460265018475 ATP binding site [chemical binding]; other site 460265018476 putative Mg++ binding site [ion binding]; other site 460265018477 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 460265018478 nucleotide binding region [chemical binding]; other site 460265018479 ATP-binding site [chemical binding]; other site 460265018480 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 460265018481 cytidylate kinase; Provisional; Region: cmk; PRK00023 460265018482 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 460265018483 CMP-binding site; other site 460265018484 The sites determining sugar specificity; other site 460265018485 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 460265018486 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 460265018487 hinge; other site 460265018488 active site 460265018489 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 460265018490 TIGR02300 family protein; Region: FYDLN_acid 460265018491 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 460265018492 homodimer interface [polypeptide binding]; other site 460265018493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265018494 catalytic residue [active] 460265018495 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 460265018496 glycerate dehydrogenase; Provisional; Region: PRK06487 460265018497 putative ligand binding site [chemical binding]; other site 460265018498 putative NAD binding site [chemical binding]; other site 460265018499 catalytic site [active] 460265018500 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 460265018501 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 460265018502 NADP binding site [chemical binding]; other site 460265018503 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 460265018504 malate--CoA ligase subunit beta; Provisional; Region: PRK14046 460265018505 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 460265018506 CoA-ligase; Region: Ligase_CoA; pfam00549 460265018507 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 460265018508 CoA binding domain; Region: CoA_binding; pfam02629 460265018509 CoA-ligase; Region: Ligase_CoA; pfam00549 460265018510 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 460265018511 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 460265018512 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 460265018513 ATP12 chaperone protein; Region: ATP12; cl02228 460265018514 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 460265018515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 460265018516 motif II; other site 460265018517 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 460265018518 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 460265018519 RNA binding surface [nucleotide binding]; other site 460265018520 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 460265018521 active site 460265018522 AAA domain; Region: AAA_31; pfam13614 460265018523 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 460265018524 P-loop; other site 460265018525 Magnesium ion binding site [ion binding]; other site 460265018526 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 460265018527 recombination factor protein RarA; Reviewed; Region: PRK13342 460265018528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265018529 Walker A motif; other site 460265018530 ATP binding site [chemical binding]; other site 460265018531 Walker B motif; other site 460265018532 arginine finger; other site 460265018533 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 460265018534 Cation efflux family; Region: Cation_efflux; cl00316 460265018535 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 460265018536 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 460265018537 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 460265018538 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 460265018539 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 460265018540 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 460265018541 active site 460265018542 motif I; other site 460265018543 motif II; other site 460265018544 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 460265018545 polysaccharide export protein Wza; Provisional; Region: PRK15078 460265018546 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 460265018547 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265018548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265018549 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265018550 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 460265018551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265018552 Walker A/P-loop; other site 460265018553 ATP binding site [chemical binding]; other site 460265018554 Q-loop/lid; other site 460265018555 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 460265018556 ABC transporter signature motif; other site 460265018557 Walker B; other site 460265018558 D-loop; other site 460265018559 ABC transporter; Region: ABC_tran_2; pfam12848 460265018560 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 460265018561 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 460265018562 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 460265018563 active site 460265018564 substrate binding site [chemical binding]; other site 460265018565 Mg2+ binding site [ion binding]; other site 460265018566 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 460265018567 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 460265018568 TPP-binding site; other site 460265018569 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 460265018570 PYR/PP interface [polypeptide binding]; other site 460265018571 dimer interface [polypeptide binding]; other site 460265018572 TPP binding site [chemical binding]; other site 460265018573 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 460265018574 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 460265018575 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 460265018576 putative NADP binding site [chemical binding]; other site 460265018577 putative substrate binding site [chemical binding]; other site 460265018578 active site 460265018579 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 460265018580 active site lid residues [active] 460265018581 substrate binding pocket [chemical binding]; other site 460265018582 catalytic residues [active] 460265018583 substrate-Mg2+ binding site; other site 460265018584 aspartate-rich region 1; other site 460265018585 aspartate-rich region 2; other site 460265018586 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 460265018587 active site lid residues [active] 460265018588 substrate binding pocket [chemical binding]; other site 460265018589 catalytic residues [active] 460265018590 substrate-Mg2+ binding site; other site 460265018591 aspartate-rich region 1; other site 460265018592 aspartate-rich region 2; other site 460265018593 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 460265018594 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 460265018595 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 460265018596 Active site cavity [active] 460265018597 catalytic acid [active] 460265018598 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 460265018599 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 460265018600 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 460265018601 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 460265018602 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 460265018603 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 460265018604 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 460265018605 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 460265018606 ligand binding site; other site 460265018607 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 460265018608 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265018609 FeS/SAM binding site; other site 460265018610 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 460265018611 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 460265018612 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 460265018613 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 460265018614 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 460265018615 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 460265018616 FeS/SAM binding site; other site 460265018617 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 460265018618 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 460265018619 classical (c) SDRs; Region: SDR_c; cd05233 460265018620 NAD(P) binding site [chemical binding]; other site 460265018621 active site 460265018622 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 460265018623 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 460265018624 putative C-terminal domain interface [polypeptide binding]; other site 460265018625 putative GSH binding site (G-site) [chemical binding]; other site 460265018626 putative dimer interface [polypeptide binding]; other site 460265018627 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 460265018628 N-terminal domain interface [polypeptide binding]; other site 460265018629 dimer interface [polypeptide binding]; other site 460265018630 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 460265018631 Response regulator receiver domain; Region: Response_reg; pfam00072 460265018632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265018633 active site 460265018634 phosphorylation site [posttranslational modification] 460265018635 intermolecular recognition site; other site 460265018636 dimerization interface [polypeptide binding]; other site 460265018637 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 460265018638 PhnA protein; Region: PhnA; pfam03831 460265018639 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 460265018640 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 460265018641 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 460265018642 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 460265018643 active site 460265018644 dimer interface [polypeptide binding]; other site 460265018645 motif 1; other site 460265018646 motif 2; other site 460265018647 motif 3; other site 460265018648 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 460265018649 anticodon binding site; other site 460265018650 hypothetical protein; Validated; Region: PRK00041 460265018651 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 460265018652 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 460265018653 trimerization site [polypeptide binding]; other site 460265018654 active site 460265018655 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 460265018656 GTP cyclohydrolase I; Provisional; Region: PLN03044 460265018657 active site 460265018658 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 460265018659 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 460265018660 active site 460265018661 nucleophile elbow; other site 460265018662 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 460265018663 transmembrane helices; other site 460265018664 Citrate transporter; Region: CitMHS; pfam03600 460265018665 Predicted permeases [General function prediction only]; Region: COG0679 460265018666 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 460265018667 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 460265018668 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 460265018669 Selenophosphate synthetase-related proteins [General function prediction only]; Region: COG2144 460265018670 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 460265018671 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 460265018672 generic binding surface II; other site 460265018673 ssDNA binding site; other site 460265018674 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 460265018675 ATP binding site [chemical binding]; other site 460265018676 putative Mg++ binding site [ion binding]; other site 460265018677 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 460265018678 nucleotide binding region [chemical binding]; other site 460265018679 ATP-binding site [chemical binding]; other site 460265018680 Uncharacterized conserved protein [Function unknown]; Region: COG2938 460265018681 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 460265018682 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 460265018683 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 460265018684 ATP binding site [chemical binding]; other site 460265018685 putative Mg++ binding site [ion binding]; other site 460265018686 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 460265018687 nucleotide binding region [chemical binding]; other site 460265018688 ATP-binding site [chemical binding]; other site 460265018689 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 460265018690 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 460265018691 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 460265018692 dimer interface [polypeptide binding]; other site 460265018693 TPP-binding site [chemical binding]; other site 460265018694 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 460265018695 2-oxoisovalerate dehydrogenase E2 component; Region: PLN02528 460265018696 E3 interaction surface; other site 460265018697 lipoyl attachment site [posttranslational modification]; other site 460265018698 e3 binding domain; Region: E3_binding; pfam02817 460265018699 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 460265018700 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 460265018701 E3 interaction surface; other site 460265018702 lipoyl attachment site [posttranslational modification]; other site 460265018703 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 460265018704 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 460265018705 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 460265018706 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 460265018707 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265018708 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 460265018709 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 460265018710 FAD binding pocket [chemical binding]; other site 460265018711 FAD binding motif [chemical binding]; other site 460265018712 phosphate binding motif [ion binding]; other site 460265018713 beta-alpha-beta structure motif; other site 460265018714 NAD(p) ribose binding residues [chemical binding]; other site 460265018715 NAD binding pocket [chemical binding]; other site 460265018716 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 460265018717 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 460265018718 catalytic loop [active] 460265018719 iron binding site [ion binding]; other site 460265018720 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 460265018721 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 460265018722 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 460265018723 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 460265018724 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 460265018725 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 460265018726 PaaX-like protein; Region: PaaX; pfam07848 460265018727 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 460265018728 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 460265018729 Transposase; Region: DEDD_Tnp_IS110; pfam01548 460265018730 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 460265018731 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 460265018732 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 460265018733 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 460265018734 N-acetyl-D-glucosamine binding site [chemical binding]; other site 460265018735 catalytic residue [active] 460265018736 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 460265018737 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 460265018738 putative FMN binding site [chemical binding]; other site 460265018739 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 460265018740 ATP-dependent DNA helicase; Q4-like; Provisional; Region: PLN03137 460265018741 EamA-like transporter family; Region: EamA; pfam00892 460265018742 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 460265018743 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265018744 DNA-binding site [nucleotide binding]; DNA binding site 460265018745 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 460265018746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265018747 homodimer interface [polypeptide binding]; other site 460265018748 catalytic residue [active] 460265018749 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 460265018750 active site 460265018751 metal binding site [ion binding]; metal-binding site 460265018752 putative phosphoesterase; Region: acc_ester; TIGR03729 460265018753 AAA domain; Region: AAA_23; pfam13476 460265018754 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265018755 Walker A/P-loop; other site 460265018756 ATP binding site [chemical binding]; other site 460265018757 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 460265018758 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 460265018759 active site 460265018760 nucleotide binding site [chemical binding]; other site 460265018761 HIGH motif; other site 460265018762 KMSKS motif; other site 460265018763 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 460265018764 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 460265018765 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 460265018766 TROVE domain; Region: TROVE; pfam05731 460265018767 Cytochrome c; Region: Cytochrom_C; cl11414 460265018768 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 460265018769 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 460265018770 putative ADP-binding pocket [chemical binding]; other site 460265018771 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 460265018772 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 460265018773 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 460265018774 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 460265018775 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 460265018776 NodB motif; other site 460265018777 putative active site [active] 460265018778 putative catalytic site [active] 460265018779 putative Zn binding site [ion binding]; other site 460265018780 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 460265018781 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265018782 Walker A/P-loop; other site 460265018783 ATP binding site [chemical binding]; other site 460265018784 Q-loop/lid; other site 460265018785 ABC transporter signature motif; other site 460265018786 Walker B; other site 460265018787 D-loop; other site 460265018788 H-loop/switch region; other site 460265018789 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 460265018790 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 460265018791 Walker A/P-loop; other site 460265018792 ATP binding site [chemical binding]; other site 460265018793 Q-loop/lid; other site 460265018794 ABC transporter signature motif; other site 460265018795 Walker B; other site 460265018796 D-loop; other site 460265018797 H-loop/switch region; other site 460265018798 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 460265018799 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 460265018800 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 460265018801 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 460265018802 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 460265018803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265018804 dimer interface [polypeptide binding]; other site 460265018805 conserved gate region; other site 460265018806 ABC-ATPase subunit interface; other site 460265018807 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 460265018808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265018809 dimer interface [polypeptide binding]; other site 460265018810 conserved gate region; other site 460265018811 putative PBP binding loops; other site 460265018812 ABC-ATPase subunit interface; other site 460265018813 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 460265018814 helicase 45; Provisional; Region: PTZ00424 460265018815 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 460265018816 ATP binding site [chemical binding]; other site 460265018817 Mg++ binding site [ion binding]; other site 460265018818 motif III; other site 460265018819 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 460265018820 nucleotide binding region [chemical binding]; other site 460265018821 ATP-binding site [chemical binding]; other site 460265018822 Nitronate monooxygenase; Region: NMO; pfam03060 460265018823 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 460265018824 FMN binding site [chemical binding]; other site 460265018825 substrate binding site [chemical binding]; other site 460265018826 putative catalytic residue [active] 460265018827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265018828 putative substrate translocation pore; other site 460265018829 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 460265018830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 460265018831 Coenzyme A binding pocket [chemical binding]; other site 460265018832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265018833 Major Facilitator Superfamily; Region: MFS_1; pfam07690 460265018834 putative substrate translocation pore; other site 460265018835 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 460265018836 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 460265018837 dimer interface [polypeptide binding]; other site 460265018838 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 460265018839 active site 460265018840 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 460265018841 substrate binding site [chemical binding]; other site 460265018842 catalytic residue [active] 460265018843 Protease inhibitor Inh; Region: Inh; pfam02974 460265018844 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 460265018845 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 460265018846 Methyltransferase domain; Region: Methyltransf_31; pfam13847 460265018847 Methyltransferase domain; Region: Methyltransf_24; pfam13578 460265018848 S-adenosylmethionine binding site [chemical binding]; other site 460265018849 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 460265018850 L-aspartate oxidase; Provisional; Region: PRK06175 460265018851 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 460265018852 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 460265018853 putative SdhC subunit interface [polypeptide binding]; other site 460265018854 putative proximal heme binding site [chemical binding]; other site 460265018855 putative Iron-sulfur protein interface [polypeptide binding]; other site 460265018856 putative proximal quinone binding site; other site 460265018857 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 460265018858 Iron-sulfur protein interface; other site 460265018859 proximal quinone binding site [chemical binding]; other site 460265018860 SdhD (CybS) interface [polypeptide binding]; other site 460265018861 proximal heme binding site [chemical binding]; other site 460265018862 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265018863 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265018864 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 460265018865 putative dimerization interface [polypeptide binding]; other site 460265018866 Homeodomain-like domain; Region: HTH_23; cl17451 460265018867 Winged helix-turn helix; Region: HTH_29; pfam13551 460265018868 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 460265018869 Integrase core domain; Region: rve; pfam00665 460265018870 Integrase core domain; Region: rve_3; pfam13683 460265018871 malonyl-CoA synthase; Validated; Region: PRK07514 460265018872 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 460265018873 acyl-activating enzyme (AAE) consensus motif; other site 460265018874 active site 460265018875 AMP binding site [chemical binding]; other site 460265018876 CoA binding site [chemical binding]; other site 460265018877 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 460265018878 DctM-like transporters; Region: DctM; pfam06808 460265018879 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 460265018880 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 460265018881 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 460265018882 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 460265018883 Transcriptional regulators [Transcription]; Region: GntR; COG1802 460265018884 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 460265018885 DNA-binding site [nucleotide binding]; DNA binding site 460265018886 FCD domain; Region: FCD; pfam07729 460265018887 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 460265018888 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 460265018889 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 460265018890 putative active site [active] 460265018891 putative substrate binding site [chemical binding]; other site 460265018892 ATP binding site [chemical binding]; other site 460265018893 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 460265018894 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 460265018895 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 460265018896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 460265018897 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 460265018898 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265018899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265018900 active site 460265018901 phosphorylation site [posttranslational modification] 460265018902 intermolecular recognition site; other site 460265018903 dimerization interface [polypeptide binding]; other site 460265018904 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 460265018905 DNA binding residues [nucleotide binding] 460265018906 dimerization interface [polypeptide binding]; other site 460265018907 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 460265018908 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 460265018909 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 460265018910 TrkA-N domain; Region: TrkA_N; pfam02254 460265018911 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 460265018912 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 460265018913 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265018914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265018915 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265018916 dimerization interface [polypeptide binding]; other site 460265018917 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 460265018918 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 460265018919 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 460265018920 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 460265018921 homodimer interface [polypeptide binding]; other site 460265018922 substrate-cofactor binding pocket; other site 460265018923 catalytic residue [active] 460265018924 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 460265018925 MarR family; Region: MarR_2; pfam12802 460265018926 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 460265018927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265018928 active site 460265018929 phosphorylation site [posttranslational modification] 460265018930 intermolecular recognition site; other site 460265018931 dimerization interface [polypeptide binding]; other site 460265018932 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265018933 DNA binding site [nucleotide binding] 460265018934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 460265018935 HAMP domain; Region: HAMP; pfam00672 460265018936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 460265018937 dimer interface [polypeptide binding]; other site 460265018938 phosphorylation site [posttranslational modification] 460265018939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265018940 ATP binding site [chemical binding]; other site 460265018941 Mg2+ binding site [ion binding]; other site 460265018942 G-X-G motif; other site 460265018943 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 460265018944 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 460265018945 putative NAD(P) binding site [chemical binding]; other site 460265018946 active site 460265018947 putative substrate binding site [chemical binding]; other site 460265018948 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 460265018949 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 460265018950 NAD binding site [chemical binding]; other site 460265018951 homotetramer interface [polypeptide binding]; other site 460265018952 homodimer interface [polypeptide binding]; other site 460265018953 active site 460265018954 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 460265018955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 460265018956 Coenzyme A binding pocket [chemical binding]; other site 460265018957 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 460265018958 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 460265018959 tetramer interface [polypeptide binding]; other site 460265018960 active site 460265018961 Mg2+/Mn2+ binding site [ion binding]; other site 460265018962 Domain of unknown function (DUF1873); Region: DUF1873; pfam08969 460265018963 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 460265018964 active site 460265018965 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 460265018966 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 460265018967 active site 460265018968 dimerization interface [polypeptide binding]; other site 460265018969 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 460265018970 Sel1-like repeats; Region: SEL1; smart00671 460265018971 Sel1 repeat; Region: Sel1; cl02723 460265018972 Sel1-like repeats; Region: SEL1; smart00671 460265018973 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 460265018974 thiamine phosphate binding site [chemical binding]; other site 460265018975 active site 460265018976 pyrophosphate binding site [ion binding]; other site 460265018977 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 460265018978 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 460265018979 intersubunit interface [polypeptide binding]; other site 460265018980 active site 460265018981 zinc binding site [ion binding]; other site 460265018982 Na+ binding site [ion binding]; other site 460265018983 Phosphoglycerate kinase; Region: PGK; pfam00162 460265018984 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 460265018985 substrate binding site [chemical binding]; other site 460265018986 hinge regions; other site 460265018987 ADP binding site [chemical binding]; other site 460265018988 catalytic site [active] 460265018989 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 460265018990 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 460265018991 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 460265018992 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 460265018993 Cell division protein ZapA; Region: ZapA; pfam05164 460265018994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 460265018995 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 460265018996 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 460265018997 dimer interface [polypeptide binding]; other site 460265018998 ADP-ribose binding site [chemical binding]; other site 460265018999 active site 460265019000 nudix motif; other site 460265019001 metal binding site [ion binding]; metal-binding site 460265019002 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 460265019003 CPxP motif; other site 460265019004 glutamate--cysteine ligase; Region: PLN02611 460265019005 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 460265019006 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 460265019007 putative active site [active] 460265019008 putative PHP Thumb interface [polypeptide binding]; other site 460265019009 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 460265019010 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 460265019011 generic binding surface II; other site 460265019012 generic binding surface I; other site 460265019013 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 460265019014 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 460265019015 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 460265019016 catalytic residues [active] 460265019017 argininosuccinate lyase; Provisional; Region: PRK00855 460265019018 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 460265019019 active sites [active] 460265019020 tetramer interface [polypeptide binding]; other site 460265019021 short chain dehydrogenase; Provisional; Region: PRK08339 460265019022 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 460265019023 putative NAD(P) binding site [chemical binding]; other site 460265019024 putative active site [active] 460265019025 Predicted integral membrane protein [Function unknown]; Region: COG5652 460265019026 Domain of unknown function DUF59; Region: DUF59; pfam01883 460265019027 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 460265019028 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 460265019029 Walker A motif; other site 460265019030 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 460265019031 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 460265019032 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 460265019033 GTP binding site; other site 460265019034 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 460265019035 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 460265019036 active site clefts [active] 460265019037 zinc binding site [ion binding]; other site 460265019038 dimer interface [polypeptide binding]; other site 460265019039 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 460265019040 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 460265019041 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 460265019042 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 460265019043 Catalytic domain of bacteriophage endosialidase; Region: End_tail_spike; pfam12219 460265019044 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 460265019045 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 460265019046 Putative phage tail protein; Region: Phage-tail_3; pfam13550 460265019047 NlpC/P60 family; Region: NLPC_P60; cl17555 460265019048 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 460265019049 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 460265019050 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 460265019051 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 460265019052 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 460265019053 Phage major tail protein 2; Region: Phage_tail_2; cl11463 460265019054 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265019055 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265019056 ligand binding site [chemical binding]; other site 460265019057 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 460265019058 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 460265019059 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 460265019060 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 460265019061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265019062 non-specific DNA binding site [nucleotide binding]; other site 460265019063 salt bridge; other site 460265019064 sequence-specific DNA binding site [nucleotide binding]; other site 460265019065 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 460265019066 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 460265019067 oligomerization interface [polypeptide binding]; other site 460265019068 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 460265019069 Phage capsid family; Region: Phage_capsid; pfam05065 460265019070 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 460265019071 oligomer interface [polypeptide binding]; other site 460265019072 active site residues [active] 460265019073 Phage-related protein [Function unknown]; Region: COG4695; cl01923 460265019074 Phage portal protein; Region: Phage_portal; pfam04860 460265019075 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 460265019076 Phage terminase, small subunit; Region: Terminase_4; pfam05119 460265019077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 460265019078 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 460265019079 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 460265019080 catalytic residues [active] 460265019081 catalytic nucleophile [active] 460265019082 Recombinase; Region: Recombinase; pfam07508 460265019083 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 460265019084 nucleophilic elbow; other site 460265019085 catalytic triad; other site 460265019086 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 460265019087 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265019088 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265019089 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265019090 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265019091 Protein of unknown function (DUF497); Region: DUF497; cl01108 460265019092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 460265019093 non-specific DNA binding site [nucleotide binding]; other site 460265019094 salt bridge; other site 460265019095 sequence-specific DNA binding site [nucleotide binding]; other site 460265019096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265019097 TPR repeat; Region: TPR_11; pfam13414 460265019098 TPR motif; other site 460265019099 binding surface 460265019100 TPR repeat; Region: TPR_11; pfam13414 460265019101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265019102 binding surface 460265019103 TPR motif; other site 460265019104 TPR repeat; Region: TPR_11; pfam13414 460265019105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265019106 binding surface 460265019107 TPR motif; other site 460265019108 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 460265019109 Tetratricopeptide repeat; Region: TPR_1; pfam00515 460265019110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265019111 TPR motif; other site 460265019112 binding surface 460265019113 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 460265019114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265019115 binding surface 460265019116 TPR motif; other site 460265019117 Tetratricopeptide repeat; Region: TPR_1; pfam00515 460265019118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265019119 binding surface 460265019120 TPR motif; other site 460265019121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 460265019122 binding surface 460265019123 TPR repeat; Region: TPR_11; pfam13414 460265019124 TPR motif; other site 460265019125 TPR repeat; Region: TPR_11; pfam13414 460265019126 Caspase domain; Region: Peptidase_C14; pfam00656 460265019127 Helix-turn-helix domain; Region: HTH_36; pfam13730 460265019128 MT-A70; Region: MT-A70; cl01947 460265019129 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 460265019130 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 460265019131 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 460265019132 ligand binding site; other site 460265019133 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 460265019134 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 460265019135 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 460265019136 GTPase Era; Reviewed; Region: era; PRK00089 460265019137 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 460265019138 G1 box; other site 460265019139 GTP/Mg2+ binding site [chemical binding]; other site 460265019140 Switch I region; other site 460265019141 G2 box; other site 460265019142 Switch II region; other site 460265019143 G3 box; other site 460265019144 G4 box; other site 460265019145 G5 box; other site 460265019146 KH domain; Region: KH_2; pfam07650 460265019147 ribonuclease III; Reviewed; Region: rnc; PRK00102 460265019148 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 460265019149 dimerization interface [polypeptide binding]; other site 460265019150 active site 460265019151 metal binding site [ion binding]; metal-binding site 460265019152 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 460265019153 dsRNA binding site [nucleotide binding]; other site 460265019154 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 460265019155 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 460265019156 Catalytic site [active] 460265019157 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 460265019158 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 460265019159 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 460265019160 active site 460265019161 hydrophilic channel; other site 460265019162 dimerization interface [polypeptide binding]; other site 460265019163 catalytic residues [active] 460265019164 active site lid [active] 460265019165 PRC-barrel domain; Region: PRC; pfam05239 460265019166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265019167 Major Facilitator Superfamily; Region: MFS_1; pfam07690 460265019168 putative substrate translocation pore; other site 460265019169 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 460265019170 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 460265019171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 460265019172 Walker A/P-loop; other site 460265019173 ATP binding site [chemical binding]; other site 460265019174 Q-loop/lid; other site 460265019175 ABC transporter signature motif; other site 460265019176 Walker B; other site 460265019177 D-loop; other site 460265019178 H-loop/switch region; other site 460265019179 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 460265019180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265019181 ATP binding site [chemical binding]; other site 460265019182 Mg2+ binding site [ion binding]; other site 460265019183 G-X-G motif; other site 460265019184 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 460265019185 ATP binding site [chemical binding]; other site 460265019186 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 460265019187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 460265019188 Coenzyme A binding pocket [chemical binding]; other site 460265019189 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 460265019190 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 460265019191 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 460265019192 DsbD alpha interface [polypeptide binding]; other site 460265019193 catalytic residues [active] 460265019194 Protein of unknown function (DUF429); Region: DUF429; cl12046 460265019195 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 460265019196 nudix motif; other site 460265019197 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 460265019198 active site clefts [active] 460265019199 zinc binding site [ion binding]; other site 460265019200 dimer interface [polypeptide binding]; other site 460265019201 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14736 460265019202 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 460265019203 gamma subunit interface [polypeptide binding]; other site 460265019204 epsilon subunit interface [polypeptide binding]; other site 460265019205 LBP interface [polypeptide binding]; other site 460265019206 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 460265019207 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 460265019208 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 460265019209 alpha subunit interaction interface [polypeptide binding]; other site 460265019210 Walker A motif; other site 460265019211 ATP binding site [chemical binding]; other site 460265019212 Walker B motif; other site 460265019213 inhibitor binding site; inhibition site 460265019214 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 460265019215 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 460265019216 core domain interface [polypeptide binding]; other site 460265019217 delta subunit interface [polypeptide binding]; other site 460265019218 epsilon subunit interface [polypeptide binding]; other site 460265019219 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 460265019220 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 460265019221 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 460265019222 beta subunit interaction interface [polypeptide binding]; other site 460265019223 Walker A motif; other site 460265019224 ATP binding site [chemical binding]; other site 460265019225 Walker B motif; other site 460265019226 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 460265019227 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 460265019228 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 460265019229 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 460265019230 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 460265019231 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 460265019232 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 460265019233 putative catalytic residue [active] 460265019234 argininosuccinate synthase; Provisional; Region: PRK13820 460265019235 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 460265019236 ANP binding site [chemical binding]; other site 460265019237 Substrate Binding Site II [chemical binding]; other site 460265019238 Substrate Binding Site I [chemical binding]; other site 460265019239 Transglycosylase; Region: Transgly; pfam00912 460265019240 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 460265019241 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 460265019242 substrate binding pocket [chemical binding]; other site 460265019243 chain length determination region; other site 460265019244 substrate-Mg2+ binding site; other site 460265019245 catalytic residues [active] 460265019246 aspartate-rich region 1; other site 460265019247 active site lid residues [active] 460265019248 aspartate-rich region 2; other site 460265019249 tartrate dehydrogenase; Region: TTC; TIGR02089 460265019250 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 460265019251 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 460265019252 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 460265019253 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 460265019254 phosphate binding site [ion binding]; other site 460265019255 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 460265019256 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 460265019257 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 460265019258 Peptidase family M23; Region: Peptidase_M23; pfam01551 460265019259 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 460265019260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265019261 S-adenosylmethionine binding site [chemical binding]; other site 460265019262 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 460265019263 seryl-tRNA synthetase; Provisional; Region: PRK05431 460265019264 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 460265019265 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 460265019266 dimer interface [polypeptide binding]; other site 460265019267 active site 460265019268 motif 1; other site 460265019269 motif 2; other site 460265019270 motif 3; other site 460265019271 hypothetical protein; Validated; Region: PRK00110 460265019272 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265019273 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 460265019274 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 460265019275 Multicopper oxidase; Region: Cu-oxidase; pfam00394 460265019276 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 460265019277 trigger factor; Provisional; Region: tig; PRK01490 460265019278 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 460265019279 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 460265019280 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 460265019281 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 460265019282 oligomer interface [polypeptide binding]; other site 460265019283 active site residues [active] 460265019284 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 460265019285 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 460265019286 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265019287 Walker A motif; other site 460265019288 ATP binding site [chemical binding]; other site 460265019289 Walker B motif; other site 460265019290 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 460265019291 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 460265019292 Found in ATP-dependent protease La (LON); Region: LON; smart00464 460265019293 Found in ATP-dependent protease La (LON); Region: LON; smart00464 460265019294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265019295 Walker A motif; other site 460265019296 ATP binding site [chemical binding]; other site 460265019297 Walker B motif; other site 460265019298 arginine finger; other site 460265019299 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 460265019300 Uncharacterized conserved protein [Function unknown]; Region: COG0062 460265019301 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 460265019302 putative substrate binding site [chemical binding]; other site 460265019303 putative ATP binding site [chemical binding]; other site 460265019304 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 460265019305 Nitrogen regulatory protein P-II; Region: P-II; smart00938 460265019306 glutamine synthetase; Provisional; Region: glnA; PRK09469 460265019307 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 460265019308 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 460265019309 ribonuclease R; Region: RNase_R; TIGR02063 460265019310 RNB domain; Region: RNB; pfam00773 460265019311 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 460265019312 RNA binding site [nucleotide binding]; other site 460265019313 Protein of unknown function (DUF983); Region: DUF983; cl02211 460265019314 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 460265019315 nudix motif; other site 460265019316 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 460265019317 response regulator PleD; Reviewed; Region: pleD; PRK09581 460265019318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265019319 active site 460265019320 phosphorylation site [posttranslational modification] 460265019321 intermolecular recognition site; other site 460265019322 dimerization interface [polypeptide binding]; other site 460265019323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265019324 active site 460265019325 phosphorylation site [posttranslational modification] 460265019326 intermolecular recognition site; other site 460265019327 dimerization interface [polypeptide binding]; other site 460265019328 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 460265019329 metal binding site [ion binding]; metal-binding site 460265019330 active site 460265019331 I-site; other site 460265019332 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 460265019333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265019334 active site 460265019335 phosphorylation site [posttranslational modification] 460265019336 intermolecular recognition site; other site 460265019337 dimerization interface [polypeptide binding]; other site 460265019338 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 460265019339 DNA polymerase IV; Provisional; Region: PRK02794 460265019340 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 460265019341 active site 460265019342 DNA binding site [nucleotide binding] 460265019343 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 460265019344 GcrA cell cycle regulator; Region: GcrA; cl11564 460265019345 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 460265019346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265019347 active site 460265019348 phosphorylation site [posttranslational modification] 460265019349 intermolecular recognition site; other site 460265019350 dimerization interface [polypeptide binding]; other site 460265019351 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 460265019352 DNA binding site [nucleotide binding] 460265019353 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 460265019354 PhoU domain; Region: PhoU; pfam01895 460265019355 PhoU domain; Region: PhoU; pfam01895 460265019356 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 460265019357 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 460265019358 Walker A/P-loop; other site 460265019359 ATP binding site [chemical binding]; other site 460265019360 Q-loop/lid; other site 460265019361 ABC transporter signature motif; other site 460265019362 Walker B; other site 460265019363 D-loop; other site 460265019364 H-loop/switch region; other site 460265019365 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 460265019366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265019367 dimer interface [polypeptide binding]; other site 460265019368 conserved gate region; other site 460265019369 putative PBP binding loops; other site 460265019370 ABC-ATPase subunit interface; other site 460265019371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 460265019372 dimer interface [polypeptide binding]; other site 460265019373 conserved gate region; other site 460265019374 putative PBP binding loops; other site 460265019375 ABC-ATPase subunit interface; other site 460265019376 PBP superfamily domain; Region: PBP_like_2; cl17296 460265019377 RNA polymerase sigma factor; Provisional; Region: PRK12547 460265019378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265019379 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 460265019380 DNA binding residues [nucleotide binding] 460265019381 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 460265019382 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 460265019383 Walker A/P-loop; other site 460265019384 ATP binding site [chemical binding]; other site 460265019385 Q-loop/lid; other site 460265019386 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 460265019387 ABC transporter signature motif; other site 460265019388 Walker B; other site 460265019389 D-loop; other site 460265019390 H-loop/switch region; other site 460265019391 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 460265019392 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 460265019393 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 460265019394 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 460265019395 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 460265019396 nucleotide binding site [chemical binding]; other site 460265019397 SulA interaction site; other site 460265019398 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 460265019399 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 460265019400 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 460265019401 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 460265019402 nucleotide binding site [chemical binding]; other site 460265019403 Cell division protein FtsA; Region: FtsA; pfam14450 460265019404 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 460265019405 Cell division protein FtsQ; Region: FtsQ; pfam03799 460265019406 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 460265019407 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 460265019408 ATP-grasp domain; Region: ATP-grasp_4; cl17255 460265019409 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 460265019410 FAD binding domain; Region: FAD_binding_4; pfam01565 460265019411 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 460265019412 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 460265019413 putative active site [active] 460265019414 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 460265019415 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 460265019416 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 460265019417 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 460265019418 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 460265019419 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 460265019420 active site 460265019421 homodimer interface [polypeptide binding]; other site 460265019422 cell division protein FtsW; Region: ftsW; TIGR02614 460265019423 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 460265019424 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 460265019425 putative active site [active] 460265019426 catalytic residue [active] 460265019427 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 460265019428 active site 460265019429 dimer interface [polypeptide binding]; other site 460265019430 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 460265019431 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 460265019432 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 460265019433 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 460265019434 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 460265019435 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 460265019436 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 460265019437 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 460265019438 putative active site [active] 460265019439 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 460265019440 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 460265019441 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 460265019442 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 460265019443 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 460265019444 trimer interface [polypeptide binding]; other site 460265019445 active site 460265019446 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 460265019447 trimer interface [polypeptide binding]; other site 460265019448 active site 460265019449 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 460265019450 acetylornithine deacetylase; Provisional; Region: PRK07522 460265019451 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 460265019452 metal binding site [ion binding]; metal-binding site 460265019453 putative dimer interface [polypeptide binding]; other site 460265019454 LysE type translocator; Region: LysE; cl00565 460265019455 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 460265019456 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 460265019457 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 460265019458 dimerization interface [polypeptide binding]; other site 460265019459 domain crossover interface; other site 460265019460 redox-dependent activation switch; other site 460265019461 ornithine carbamoyltransferase; Provisional; Region: PRK00779 460265019462 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 460265019463 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 460265019464 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 460265019465 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 460265019466 inhibitor-cofactor binding pocket; inhibition site 460265019467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265019468 catalytic residue [active] 460265019469 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 460265019470 homotrimer interaction site [polypeptide binding]; other site 460265019471 putative active site [active] 460265019472 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 460265019473 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 460265019474 active site 460265019475 catalytic site [active] 460265019476 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 460265019477 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 460265019478 4Fe-4S binding domain; Region: Fer4_5; pfam12801 460265019479 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 460265019480 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 460265019481 FixH; Region: FixH; pfam05751 460265019482 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 460265019483 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 460265019484 metal-binding site [ion binding] 460265019485 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 460265019486 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 460265019487 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 460265019488 Zn2+ binding site [ion binding]; other site 460265019489 Mg2+ binding site [ion binding]; other site 460265019490 LexA repressor; Validated; Region: PRK00215 460265019491 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 460265019492 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 460265019493 Catalytic site [active] 460265019494 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 460265019495 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 460265019496 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 460265019497 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 460265019498 classical (c) SDRs; Region: SDR_c; cd05233 460265019499 NAD(P) binding site [chemical binding]; other site 460265019500 active site 460265019501 putative acyltransferase; Provisional; Region: PRK05790 460265019502 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 460265019503 dimer interface [polypeptide binding]; other site 460265019504 active site 460265019505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265019506 Major Facilitator Superfamily; Region: MFS_1; pfam07690 460265019507 putative substrate translocation pore; other site 460265019508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265019509 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 460265019510 HlyD family secretion protein; Region: HlyD_3; pfam13437 460265019511 Predicted transcriptional regulators [Transcription]; Region: COG1733 460265019512 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 460265019513 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 460265019514 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265019515 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265019516 ligand binding site [chemical binding]; other site 460265019517 flexible hinge region; other site 460265019518 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 460265019519 putative switch regulator; other site 460265019520 non-specific DNA interactions [nucleotide binding]; other site 460265019521 DNA binding site [nucleotide binding] 460265019522 sequence specific DNA binding site [nucleotide binding]; other site 460265019523 putative cAMP binding site [chemical binding]; other site 460265019524 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 460265019525 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265019526 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265019527 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265019528 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265019529 Uncharacterized conserved protein [Function unknown]; Region: COG5361 460265019530 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 460265019531 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 460265019532 DEAD-like helicases superfamily; Region: DEXDc; smart00487 460265019533 DEAD/DEAH box helicase; Region: DEAD; pfam00270 460265019534 ATP binding site [chemical binding]; other site 460265019535 Winged helix-turn helix; Region: HTH_29; pfam13551 460265019536 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265019537 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265019538 ligand binding site [chemical binding]; other site 460265019539 flexible hinge region; other site 460265019540 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 460265019541 putative switch regulator; other site 460265019542 non-specific DNA interactions [nucleotide binding]; other site 460265019543 DNA binding site [nucleotide binding] 460265019544 sequence specific DNA binding site [nucleotide binding]; other site 460265019545 putative cAMP binding site [chemical binding]; other site 460265019546 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 460265019547 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 460265019548 catalytic residues [active] 460265019549 catalytic nucleophile [active] 460265019550 Recombinase; Region: Recombinase; pfam07508 460265019551 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 460265019552 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 460265019553 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 460265019554 Winged helix-turn helix; Region: HTH_29; pfam13551 460265019555 Helix-turn-helix domain; Region: HTH_28; pfam13518 460265019556 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 460265019557 DDE superfamily endonuclease; Region: DDE_3; pfam13358 460265019558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 460265019559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265019560 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265019561 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265019562 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 460265019563 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 460265019564 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 460265019565 active site 460265019566 Int/Topo IB signature motif; other site 460265019567 DNA binding site [nucleotide binding] 460265019568 salicylate hydroxylase; Provisional; Region: PRK08163 460265019569 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 460265019570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 460265019571 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 460265019572 active site 460265019573 hypothetical protein; Reviewed; Region: PRK00024 460265019574 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 460265019575 MPN+ (JAMM) motif; other site 460265019576 Zinc-binding site [ion binding]; other site 460265019577 Uncharacterized conserved protein [Function unknown]; Region: COG2308 460265019578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 460265019579 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 460265019580 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 460265019581 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 460265019582 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 460265019583 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 460265019584 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 460265019585 active site 460265019586 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 460265019587 thiamine phosphate binding site [chemical binding]; other site 460265019588 active site 460265019589 pyrophosphate binding site [ion binding]; other site 460265019590 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 460265019591 ThiS interaction site; other site 460265019592 putative active site [active] 460265019593 tetramer interface [polypeptide binding]; other site 460265019594 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 460265019595 thiS-thiF/thiG interaction site; other site 460265019596 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 460265019597 hydroxyglutarate oxidase; Provisional; Region: PRK11728 460265019598 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 460265019599 cyclase homology domain; Region: CHD; cd07302 460265019600 nucleotidyl binding site; other site 460265019601 metal binding site [ion binding]; metal-binding site 460265019602 dimer interface [polypeptide binding]; other site 460265019603 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 460265019604 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 460265019605 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 460265019606 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 460265019607 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265019608 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 460265019609 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 460265019610 DNA binding residues [nucleotide binding] 460265019611 DNA primase; Validated; Region: dnaG; PRK05667 460265019612 CHC2 zinc finger; Region: zf-CHC2; pfam01807 460265019613 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 460265019614 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 460265019615 active site 460265019616 metal binding site [ion binding]; metal-binding site 460265019617 interdomain interaction site; other site 460265019618 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 460265019619 Transglycosylase; Region: Transgly; pfam00912 460265019620 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 460265019621 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 460265019622 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 460265019623 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 460265019624 Histidine kinase; Region: HisKA_3; pfam07730 460265019625 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 460265019626 ATP binding site [chemical binding]; other site 460265019627 Mg2+ binding site [ion binding]; other site 460265019628 G-X-G motif; other site 460265019629 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 460265019630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265019631 active site 460265019632 phosphorylation site [posttranslational modification] 460265019633 intermolecular recognition site; other site 460265019634 dimerization interface [polypeptide binding]; other site 460265019635 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 460265019636 DNA binding residues [nucleotide binding] 460265019637 dimerization interface [polypeptide binding]; other site 460265019638 pantothenate kinase; Provisional; Region: PRK05439 460265019639 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 460265019640 ATP-binding site [chemical binding]; other site 460265019641 CoA-binding site [chemical binding]; other site 460265019642 Mg2+-binding site [ion binding]; other site 460265019643 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 460265019644 metal binding site [ion binding]; metal-binding site 460265019645 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 460265019646 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 460265019647 substrate binding site [chemical binding]; other site 460265019648 glutamase interaction surface [polypeptide binding]; other site 460265019649 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 460265019650 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 460265019651 catalytic residues [active] 460265019652 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 460265019653 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 460265019654 putative active site [active] 460265019655 oxyanion strand; other site 460265019656 catalytic triad [active] 460265019657 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 460265019658 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 460265019659 putative active site pocket [active] 460265019660 4-fold oligomerization interface [polypeptide binding]; other site 460265019661 metal binding residues [ion binding]; metal-binding site 460265019662 3-fold/trimer interface [polypeptide binding]; other site 460265019663 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 460265019664 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 460265019665 cytochrome b; Provisional; Region: CYTB; MTH00191 460265019666 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 460265019667 Qi binding site; other site 460265019668 intrachain domain interface; other site 460265019669 interchain domain interface [polypeptide binding]; other site 460265019670 heme bH binding site [chemical binding]; other site 460265019671 heme bL binding site [chemical binding]; other site 460265019672 Qo binding site; other site 460265019673 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 460265019674 interchain domain interface [polypeptide binding]; other site 460265019675 intrachain domain interface; other site 460265019676 Qi binding site; other site 460265019677 Qo binding site; other site 460265019678 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 460265019679 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 460265019680 [2Fe-2S] cluster binding site [ion binding]; other site 460265019681 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 460265019682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 460265019683 putative substrate translocation pore; other site 460265019684 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 460265019685 homopentamer interface [polypeptide binding]; other site 460265019686 active site 460265019687 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 460265019688 putative RNA binding site [nucleotide binding]; other site 460265019689 thiamine monophosphate kinase; Provisional; Region: PRK05731 460265019690 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 460265019691 ATP binding site [chemical binding]; other site 460265019692 dimerization interface [polypeptide binding]; other site 460265019693 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 460265019694 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 460265019695 aspartate aminotransferase; Provisional; Region: PRK06108 460265019696 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 460265019697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265019698 homodimer interface [polypeptide binding]; other site 460265019699 catalytic residue [active] 460265019700 glycogen branching enzyme; Provisional; Region: PRK05402 460265019701 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 460265019702 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 460265019703 active site 460265019704 catalytic site [active] 460265019705 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 460265019706 trehalose synthase; Region: treS_nterm; TIGR02456 460265019707 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 460265019708 active site 460265019709 catalytic site [active] 460265019710 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 460265019711 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 460265019712 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 460265019713 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 460265019714 active site 460265019715 catalytic site [active] 460265019716 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 460265019717 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 460265019718 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 460265019719 active site 460265019720 homodimer interface [polypeptide binding]; other site 460265019721 catalytic site [active] 460265019722 acceptor binding site [chemical binding]; other site 460265019723 putative bifunctional 4-alpha-glucanotransferase/malto-oligosyltrehalose synthase; Provisional; Region: PRK14507 460265019724 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 460265019725 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 460265019726 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 460265019727 active site 460265019728 catalytic site [active] 460265019729 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 460265019730 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 460265019731 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 460265019732 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 460265019733 catalytic site [active] 460265019734 active site 460265019735 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 460265019736 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 460265019737 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 460265019738 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 460265019739 active site 460265019740 catalytic site [active] 460265019741 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 460265019742 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 460265019743 active site 460265019744 homotetramer interface [polypeptide binding]; other site 460265019745 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 460265019746 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 460265019747 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 460265019748 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 460265019749 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 460265019750 GAF domain; Region: GAF; pfam01590 460265019751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265019752 Walker A motif; other site 460265019753 ATP binding site [chemical binding]; other site 460265019754 Walker B motif; other site 460265019755 arginine finger; other site 460265019756 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 460265019757 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 460265019758 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 460265019759 NAD(P) binding site [chemical binding]; other site 460265019760 catalytic residues [active] 460265019761 Protein of unknown function (DUF779); Region: DUF779; pfam05610 460265019762 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 460265019763 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 460265019764 Cell division protein 48 (CDC48) domain 2; Region: CDC48_2; smart01072 460265019765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265019766 Walker A motif; other site 460265019767 ATP binding site [chemical binding]; other site 460265019768 Walker B motif; other site 460265019769 arginine finger; other site 460265019770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 460265019771 Walker A motif; other site 460265019772 ATP binding site [chemical binding]; other site 460265019773 Walker B motif; other site 460265019774 arginine finger; other site 460265019775 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 460265019776 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 460265019777 active site 460265019778 metal binding site [ion binding]; metal-binding site 460265019779 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 460265019780 diiron binding motif [ion binding]; other site 460265019781 CCC1-related family of proteins; Region: CCC1_like; cl00278 460265019782 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 460265019783 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 460265019784 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 460265019785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 460265019786 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 460265019787 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 460265019788 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 460265019789 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 460265019790 substrate binding site [chemical binding]; other site 460265019791 oxyanion hole (OAH) forming residues; other site 460265019792 trimer interface [polypeptide binding]; other site 460265019793 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 460265019794 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 460265019795 dimer interface [polypeptide binding]; other site 460265019796 allosteric magnesium binding site [ion binding]; other site 460265019797 active site 460265019798 aspartate-rich active site metal binding site; other site 460265019799 Schiff base residues; other site 460265019800 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 460265019801 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 460265019802 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 460265019803 TrkA-N domain; Region: TrkA_N; pfam02254 460265019804 TrkA-C domain; Region: TrkA_C; pfam02080 460265019805 threonine dehydratase; Provisional; Region: PRK07334 460265019806 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 460265019807 tetramer interface [polypeptide binding]; other site 460265019808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265019809 catalytic residue [active] 460265019810 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 460265019811 RDD family; Region: RDD; pfam06271 460265019812 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 460265019813 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 460265019814 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 460265019815 adenylosuccinate lyase; Provisional; Region: PRK07492 460265019816 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 460265019817 tetramer interface [polypeptide binding]; other site 460265019818 active site 460265019819 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 460265019820 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 460265019821 inhibitor site; inhibition site 460265019822 active site 460265019823 dimer interface [polypeptide binding]; other site 460265019824 catalytic residue [active] 460265019825 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 460265019826 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 460265019827 homodimer interface [polypeptide binding]; other site 460265019828 substrate-cofactor binding pocket; other site 460265019829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 460265019830 catalytic residue [active] 460265019831 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 460265019832 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 460265019833 GDP-binding site [chemical binding]; other site 460265019834 ACT binding site; other site 460265019835 IMP binding site; other site 460265019836 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 460265019837 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 460265019838 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 460265019839 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 460265019840 DNA binding residues [nucleotide binding] 460265019841 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 460265019842 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 460265019843 RNA binding surface [nucleotide binding]; other site 460265019844 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 460265019845 active site 460265019846 Helix-turn-helix domain; Region: HTH_17; cl17695 460265019847 AAA domain; Region: AAA_25; pfam13481 460265019848 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 460265019849 Walker A motif; other site 460265019850 ATP binding site [chemical binding]; other site 460265019851 Walker B motif; other site 460265019852 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 460265019853 Zn binding site [ion binding]; other site 460265019854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 460265019855 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265019856 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 460265019857 arginine:agmatin antiporter; Provisional; Region: PRK10644 460265019858 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 460265019859 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 460265019860 active site 460265019861 catalytic site [active] 460265019862 substrate binding site [chemical binding]; other site 460265019863 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 460265019864 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265019865 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265019866 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265019867 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265019868 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 460265019869 Phasin protein; Region: Phasin_2; pfam09361 460265019870 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 460265019871 Domain of unknown function DUF21; Region: DUF21; pfam01595 460265019872 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 460265019873 Transporter associated domain; Region: CorC_HlyC; smart01091 460265019874 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 460265019875 Transcriptional regulator [Transcription]; Region: LysR; COG0583 460265019876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 460265019877 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 460265019878 dimerization interface [polypeptide binding]; other site 460265019879 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 460265019880 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265019881 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 460265019882 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 460265019883 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 460265019884 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 460265019885 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 460265019886 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 460265019887 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 460265019888 Phage integrase family; Region: Phage_integrase; pfam00589 460265019889 active site 460265019890 DNA binding site [nucleotide binding] 460265019891 Int/Topo IB signature motif; other site 460265019892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 460265019893 S-adenosylmethionine binding site [chemical binding]; other site 460265019894 NADH(P)-binding; Region: NAD_binding_10; pfam13460 460265019895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 460265019896 NAD(P) binding site [chemical binding]; other site 460265019897 active site 460265019898 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 460265019899 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 460265019900 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 460265019901 nucleotide binding site [chemical binding]; other site 460265019902 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 460265019903 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 460265019904 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 460265019905 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 460265019906 minor groove reading motif; other site 460265019907 helix-hairpin-helix signature motif; other site 460265019908 substrate binding pocket [chemical binding]; other site 460265019909 active site 460265019910 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 460265019911 DNA binding and oxoG recognition site [nucleotide binding] 460265019912 Protein of unknown function (DUF721); Region: DUF721; cl02324 460265019913 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 460265019914 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 460265019915 catalytic residues [active] 460265019916 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 460265019917 Walker A/P-loop; other site 460265019918 ATP binding site [chemical binding]; other site 460265019919 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 460265019920 ABC transporter signature motif; other site 460265019921 Walker B; other site 460265019922 D-loop; other site 460265019923 H-loop/switch region; other site 460265019924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 460265019925 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 460265019926 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 460265019927 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 460265019928 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 460265019929 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 460265019930 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 460265019931 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 460265019932 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 460265019933 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 460265019934 nucleophilic elbow; other site 460265019935 catalytic triad; other site 460265019936 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 460265019937 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 460265019938 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 460265019939 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 460265019940 putative MPT binding site; other site 460265019941 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 460265019942 active site 460265019943 short chain dehydrogenase; Provisional; Region: PRK07109 460265019944 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 460265019945 putative NAD(P) binding site [chemical binding]; other site 460265019946 active site 460265019947 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 460265019948 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 460265019949 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 460265019950 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 460265019951 Cytochrome c [Energy production and conversion]; Region: COG3258 460265019952 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 460265019953 GIY-YIG motif/motif A; other site 460265019954 putative active site [active] 460265019955 putative metal binding site [ion binding]; other site 460265019956 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 460265019957 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 460265019958 oligomer interface [polypeptide binding]; other site 460265019959 metal binding site [ion binding]; metal-binding site 460265019960 metal binding site [ion binding]; metal-binding site 460265019961 putative Cl binding site [ion binding]; other site 460265019962 basic sphincter; other site 460265019963 hydrophobic gate; other site 460265019964 periplasmic entrance; other site 460265019965 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 460265019966 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 460265019967 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 460265019968 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 460265019969 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 460265019970 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 460265019971 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 460265019972 agmatinase; Region: agmatinase; TIGR01230 460265019973 oligomer interface [polypeptide binding]; other site 460265019974 putative active site [active] 460265019975 Mn binding site [ion binding]; other site 460265019976 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 460265019977 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 460265019978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265019979 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 460265019980 putative active site [active] 460265019981 heme pocket [chemical binding]; other site 460265019982 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 460265019983 putative active site [active] 460265019984 heme pocket [chemical binding]; other site 460265019985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265019986 ATP binding site [chemical binding]; other site 460265019987 Mg2+ binding site [ion binding]; other site 460265019988 G-X-G motif; other site 460265019989 Response regulator receiver domain; Region: Response_reg; pfam00072 460265019990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 460265019991 active site 460265019992 phosphorylation site [posttranslational modification] 460265019993 intermolecular recognition site; other site 460265019994 dimerization interface [polypeptide binding]; other site 460265019995 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 460265019996 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 460265019997 Histidine kinase; Region: HisKA_2; pfam07568 460265019998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 460265019999 ATP binding site [chemical binding]; other site 460265020000 Mg2+ binding site [ion binding]; other site 460265020001 G-X-G motif; other site 460265020002 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 460265020003 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 460265020004 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 460265020005 ligand binding site [chemical binding]; other site 460265020006 flexible hinge region; other site 460265020007 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 460265020008 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 460265020009 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 460265020010 catalytic residues [active] 460265020011 catalytic nucleophile [active] 460265020012 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 460265020013 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 460265020014 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 460265020015 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 460265020016 oligomeric interface; other site 460265020017 putative active site [active] 460265020018 homodimer interface [polypeptide binding]; other site 460265020019 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 460265020020 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 460265020021 inhibitor site; inhibition site 460265020022 active site 460265020023 dimer interface [polypeptide binding]; other site 460265020024 catalytic residue [active] 460265020025 hypothetical protein; Region: PHA01623 460265020026 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 460265020027 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 460265020028 P-loop; other site 460265020029 Magnesium ion binding site [ion binding]; other site 460265020030 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 460265020031 putative active site [active] 460265020032 putative metal binding residues [ion binding]; other site 460265020033 signature motif; other site 460265020034 putative dimer interface [polypeptide binding]; other site 460265020035 putative phosphate binding site [ion binding]; other site 460265020036 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 460265020037 nudix motif; other site