-- dump date 20140619_144654 -- class Genbank::misc_feature -- table misc_feature_note -- id note 441620000001 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 441620000002 oligomerization interface [polypeptide binding]; other site 441620000003 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 441620000004 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 441620000005 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 441620000006 Phage terminase, small subunit; Region: Terminase_4; pfam05119 441620000007 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 441620000008 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441620000009 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441620000010 catalytic residue [active] 441620000011 MarR family; Region: MarR_2; pfam12802 441620000012 Protein of unknown function, DUF417; Region: DUF417; cl01162 441620000013 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 441620000014 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 441620000015 catalytic residues [active] 441620000016 catalytic nucleophile [active] 441620000017 Presynaptic Site I dimer interface [polypeptide binding]; other site 441620000018 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 441620000019 Synaptic Flat tetramer interface [polypeptide binding]; other site 441620000020 Synaptic Site I dimer interface [polypeptide binding]; other site 441620000021 DNA binding site [nucleotide binding] 441620000022 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 441620000023 DNA-binding interface [nucleotide binding]; DNA binding site 441620000024 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 441620000025 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 441620000026 ParA-like protein; Provisional; Region: PHA02518 441620000027 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441620000028 Phage-related protein [Function unknown]; Region: COG4695; cl01923 441620000029 Phage portal protein; Region: Phage_portal; pfam04860 441620000030 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 441620000031 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 441620000032 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 441620000033 Phage capsid family; Region: Phage_capsid; pfam05065 441620000034 Phage minor tail protein; Region: Phage_min_tail; cl01940 441620000035 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 441620000036 DnaA N-terminal domain; Region: DnaA_N; pfam11638 441620000037 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 441620000038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 441620000039 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 441620000040 DnaA box-binding interface [nucleotide binding]; other site 441620000041 DNA polymerase III subunit beta; Validated; Region: PRK05643 441620000042 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 441620000043 putative DNA binding surface [nucleotide binding]; other site 441620000044 dimer interface [polypeptide binding]; other site 441620000045 beta-clamp/clamp loader binding surface; other site 441620000046 beta-clamp/translesion DNA polymerase binding surface; other site 441620000047 recombination protein F; Reviewed; Region: recF; PRK00064 441620000048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620000049 Walker A/P-loop; other site 441620000050 ATP binding site [chemical binding]; other site 441620000051 Q-loop/lid; other site 441620000052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620000053 ABC transporter signature motif; other site 441620000054 Walker B; other site 441620000055 D-loop; other site 441620000056 H-loop/switch region; other site 441620000057 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 441620000058 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 441620000059 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441620000060 ATP binding site [chemical binding]; other site 441620000061 putative Mg++ binding site [ion binding]; other site 441620000062 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441620000063 nucleotide binding region [chemical binding]; other site 441620000064 ATP-binding site [chemical binding]; other site 441620000065 RQC domain; Region: RQC; pfam09382 441620000066 HRDC domain; Region: HRDC; pfam00570 441620000067 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 441620000068 AAA domain; Region: AAA_30; pfam13604 441620000069 Family description; Region: UvrD_C_2; pfam13538 441620000070 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 441620000071 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 441620000072 dimerization interface [polypeptide binding]; other site 441620000073 ATP binding site [chemical binding]; other site 441620000074 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 441620000075 dimerization interface [polypeptide binding]; other site 441620000076 ATP binding site [chemical binding]; other site 441620000077 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 441620000078 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 441620000079 putative GSH binding site [chemical binding]; other site 441620000080 catalytic residues [active] 441620000081 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 441620000082 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441620000083 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 441620000084 50S ribosomal protein L22/unknown domain fusion protein; Provisional; Region: PRK12279 441620000085 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 441620000086 heme-binding residues [chemical binding]; other site 441620000087 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 441620000088 molybdopterin cofactor binding site; other site 441620000089 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 441620000090 4Fe-4S binding domain; Region: Fer4_2; pfam12797 441620000091 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 441620000092 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 441620000093 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 441620000094 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 441620000095 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 441620000096 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 441620000097 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 441620000098 Cytochrome c; Region: Cytochrom_C; pfam00034 441620000099 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 441620000100 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 441620000101 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 441620000102 Subunit I/III interface [polypeptide binding]; other site 441620000103 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 441620000104 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 441620000105 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441620000106 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441620000107 catalytic residue [active] 441620000108 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 441620000109 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082 441620000110 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 441620000111 major curlin subunit; Provisional; Region: csgA; PRK10051 441620000112 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 441620000113 DNA binding residues [nucleotide binding] 441620000114 dimerization interface [polypeptide binding]; other site 441620000115 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000116 putative active site [active] 441620000117 PAS fold; Region: PAS_3; pfam08447 441620000118 heme pocket [chemical binding]; other site 441620000119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620000120 dimer interface [polypeptide binding]; other site 441620000121 phosphorylation site [posttranslational modification] 441620000122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620000123 ATP binding site [chemical binding]; other site 441620000124 Mg2+ binding site [ion binding]; other site 441620000125 G-X-G motif; other site 441620000126 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620000127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620000128 active site 441620000129 phosphorylation site [posttranslational modification] 441620000130 intermolecular recognition site; other site 441620000131 dimerization interface [polypeptide binding]; other site 441620000132 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 441620000133 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441620000134 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441620000135 Walker A motif; other site 441620000136 Walker A motif; other site 441620000137 ATP binding site [chemical binding]; other site 441620000138 Walker B motif; other site 441620000139 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441620000140 ATP binding site [chemical binding]; other site 441620000141 Walker A motif; other site 441620000142 Walker B motif; other site 441620000143 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000144 PAS domain; Region: PAS_9; pfam13426 441620000145 putative active site [active] 441620000146 heme pocket [chemical binding]; other site 441620000147 PAS fold; Region: PAS_4; pfam08448 441620000148 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000149 putative active site [active] 441620000150 heme pocket [chemical binding]; other site 441620000151 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 441620000152 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000153 putative active site [active] 441620000154 heme pocket [chemical binding]; other site 441620000155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620000156 dimer interface [polypeptide binding]; other site 441620000157 phosphorylation site [posttranslational modification] 441620000158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620000159 ATP binding site [chemical binding]; other site 441620000160 Mg2+ binding site [ion binding]; other site 441620000161 G-X-G motif; other site 441620000162 Response regulator receiver domain; Region: Response_reg; pfam00072 441620000163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620000164 active site 441620000165 phosphorylation site [posttranslational modification] 441620000166 intermolecular recognition site; other site 441620000167 dimerization interface [polypeptide binding]; other site 441620000168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 441620000169 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 441620000170 short chain dehydrogenase; Provisional; Region: PRK07109 441620000171 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 441620000172 putative NAD(P) binding site [chemical binding]; other site 441620000173 active site 441620000174 Transcriptional regulators [Transcription]; Region: GntR; COG1802 441620000175 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441620000176 DNA-binding site [nucleotide binding]; DNA binding site 441620000177 FCD domain; Region: FCD; pfam07729 441620000178 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 441620000179 Malonate transporter MadL subunit; Region: MadL; cl04273 441620000180 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 441620000181 Coenzyme A transferase; Region: CoA_trans; cl17247 441620000182 malonate decarboxylase subunit delta; Provisional; Region: PRK02103 441620000183 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 441620000184 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 441620000185 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 441620000186 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 441620000187 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 441620000188 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 441620000189 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 441620000190 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 441620000191 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441620000192 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441620000193 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 441620000194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441620000195 DNA-binding site [nucleotide binding]; DNA binding site 441620000196 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441620000197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620000198 homodimer interface [polypeptide binding]; other site 441620000199 catalytic residue [active] 441620000200 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 441620000201 Predicted amidohydrolase [General function prediction only]; Region: COG0388 441620000202 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 441620000203 putative active site [active] 441620000204 catalytic triad [active] 441620000205 putative dimer interface [polypeptide binding]; other site 441620000206 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 441620000207 putative N-acetyltransferase, MSMEG_0567 N-terminal domain family; Region: MSMEG_0567_GNAT; TIGR04045 441620000208 Coenzyme A binding pocket [chemical binding]; other site 441620000209 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 441620000210 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 441620000211 dimerization interface [polypeptide binding]; other site 441620000212 putative ATP binding site [chemical binding]; other site 441620000213 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441620000214 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 441620000215 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 441620000216 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 441620000217 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 441620000218 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441620000219 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 441620000220 superantigen-like protein; Reviewed; Region: PRK13335 441620000221 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 441620000222 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 441620000223 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441620000224 active site 441620000225 Int/Topo IB signature motif; other site 441620000226 DNA binding site [nucleotide binding] 441620000227 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 441620000228 active site 441620000229 metal binding site [ion binding]; metal-binding site 441620000230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 441620000231 Integrase core domain; Region: rve; pfam00665 441620000232 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 441620000233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620000234 Walker A motif; other site 441620000235 ATP binding site [chemical binding]; other site 441620000236 Walker B motif; other site 441620000237 arginine finger; other site 441620000238 HIRAN domain; Region: HIRAN; pfam08797 441620000239 TIR domain; Region: TIR_2; pfam13676 441620000240 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620000241 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620000242 metal binding site [ion binding]; metal-binding site 441620000243 active site 441620000244 I-site; other site 441620000245 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 441620000246 PAS fold; Region: PAS_4; pfam08448 441620000247 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000248 putative active site [active] 441620000249 heme pocket [chemical binding]; other site 441620000250 PAS fold; Region: PAS_4; pfam08448 441620000251 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620000252 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620000253 dimer interface [polypeptide binding]; other site 441620000254 phosphorylation site [posttranslational modification] 441620000255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620000256 ATP binding site [chemical binding]; other site 441620000257 Mg2+ binding site [ion binding]; other site 441620000258 G-X-G motif; other site 441620000259 Response regulator receiver domain; Region: Response_reg; pfam00072 441620000260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620000261 active site 441620000262 phosphorylation site [posttranslational modification] 441620000263 intermolecular recognition site; other site 441620000264 dimerization interface [polypeptide binding]; other site 441620000265 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620000266 GAF domain; Region: GAF; pfam01590 441620000267 GAF domain; Region: GAF; pfam01590 441620000268 GAF domain; Region: GAF_2; pfam13185 441620000269 PAS domain S-box; Region: sensory_box; TIGR00229 441620000270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000271 putative active site [active] 441620000272 heme pocket [chemical binding]; other site 441620000273 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000274 PAS fold; Region: PAS_3; pfam08447 441620000275 putative active site [active] 441620000276 heme pocket [chemical binding]; other site 441620000277 PAS domain; Region: PAS_9; pfam13426 441620000278 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620000279 HWE histidine kinase; Region: HWE_HK; smart00911 441620000280 Response regulator receiver domain; Region: Response_reg; pfam00072 441620000281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620000282 active site 441620000283 phosphorylation site [posttranslational modification] 441620000284 intermolecular recognition site; other site 441620000285 dimerization interface [polypeptide binding]; other site 441620000286 CHASE3 domain; Region: CHASE3; pfam05227 441620000287 PAS fold; Region: PAS_7; pfam12860 441620000288 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620000289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620000290 dimer interface [polypeptide binding]; other site 441620000291 phosphorylation site [posttranslational modification] 441620000292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620000293 ATP binding site [chemical binding]; other site 441620000294 Mg2+ binding site [ion binding]; other site 441620000295 G-X-G motif; other site 441620000296 Response regulator receiver domain; Region: Response_reg; pfam00072 441620000297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620000298 active site 441620000299 phosphorylation site [posttranslational modification] 441620000300 intermolecular recognition site; other site 441620000301 dimerization interface [polypeptide binding]; other site 441620000302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620000303 dimer interface [polypeptide binding]; other site 441620000304 phosphorylation site [posttranslational modification] 441620000305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620000306 ATP binding site [chemical binding]; other site 441620000307 Mg2+ binding site [ion binding]; other site 441620000308 G-X-G motif; other site 441620000309 Response regulator receiver domain; Region: Response_reg; pfam00072 441620000310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620000311 active site 441620000312 phosphorylation site [posttranslational modification] 441620000313 intermolecular recognition site; other site 441620000314 dimerization interface [polypeptide binding]; other site 441620000315 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000316 PAS fold; Region: PAS_3; pfam08447 441620000317 putative active site [active] 441620000318 heme pocket [chemical binding]; other site 441620000319 PAS domain; Region: PAS_9; pfam13426 441620000320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000321 putative active site [active] 441620000322 heme pocket [chemical binding]; other site 441620000323 PAS fold; Region: PAS_4; pfam08448 441620000324 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000325 putative active site [active] 441620000326 heme pocket [chemical binding]; other site 441620000327 PAS domain; Region: PAS_9; pfam13426 441620000328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000329 putative active site [active] 441620000330 heme pocket [chemical binding]; other site 441620000331 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620000332 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620000333 dimer interface [polypeptide binding]; other site 441620000334 phosphorylation site [posttranslational modification] 441620000335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620000336 ATP binding site [chemical binding]; other site 441620000337 Mg2+ binding site [ion binding]; other site 441620000338 G-X-G motif; other site 441620000339 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620000340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620000341 active site 441620000342 phosphorylation site [posttranslational modification] 441620000343 intermolecular recognition site; other site 441620000344 dimerization interface [polypeptide binding]; other site 441620000345 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 441620000346 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 441620000347 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 441620000348 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 441620000349 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 441620000350 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 441620000351 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 441620000352 dimerization interface [polypeptide binding]; other site 441620000353 Domain of unknown function (DUF305); Region: DUF305; cl17794 441620000354 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 441620000355 Protein export membrane protein; Region: SecD_SecF; cl14618 441620000356 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 441620000357 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620000358 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441620000359 metal-binding site [ion binding] 441620000360 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 441620000361 active site residue [active] 441620000362 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 441620000363 Sulphur transport; Region: Sulf_transp; pfam04143 441620000364 Predicted transporter component [General function prediction only]; Region: COG2391 441620000365 DsrE/DsrF-like family; Region: DrsE; cl00672 441620000366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 441620000367 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441620000368 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 441620000369 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 441620000370 catalytic residues [active] 441620000371 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 441620000372 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 441620000373 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 441620000374 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441620000375 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 441620000376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620000377 active site 441620000378 phosphorylation site [posttranslational modification] 441620000379 intermolecular recognition site; other site 441620000380 dimerization interface [polypeptide binding]; other site 441620000381 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620000382 DNA binding site [nucleotide binding] 441620000383 sensor protein QseC; Provisional; Region: PRK10337 441620000384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620000385 dimer interface [polypeptide binding]; other site 441620000386 phosphorylation site [posttranslational modification] 441620000387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620000388 ATP binding site [chemical binding]; other site 441620000389 Mg2+ binding site [ion binding]; other site 441620000390 G-X-G motif; other site 441620000391 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 441620000392 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 441620000393 putative hydrophobic ligand binding site [chemical binding]; other site 441620000394 protein interface [polypeptide binding]; other site 441620000395 gate; other site 441620000396 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 441620000397 putative active site [active] 441620000398 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 441620000399 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 441620000400 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441620000401 dimerization interface [polypeptide binding]; other site 441620000402 putative Zn2+ binding site [ion binding]; other site 441620000403 putative DNA binding site [nucleotide binding]; other site 441620000404 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441620000405 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441620000406 ligand binding site [chemical binding]; other site 441620000407 flexible hinge region; other site 441620000408 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 441620000409 non-specific DNA interactions [nucleotide binding]; other site 441620000410 DNA binding site [nucleotide binding] 441620000411 sequence specific DNA binding site [nucleotide binding]; other site 441620000412 putative cAMP binding site [chemical binding]; other site 441620000413 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620000414 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 441620000415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620000416 dimer interface [polypeptide binding]; other site 441620000417 phosphorylation site [posttranslational modification] 441620000418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620000419 ATP binding site [chemical binding]; other site 441620000420 Mg2+ binding site [ion binding]; other site 441620000421 G-X-G motif; other site 441620000422 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620000423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620000424 active site 441620000425 phosphorylation site [posttranslational modification] 441620000426 intermolecular recognition site; other site 441620000427 dimerization interface [polypeptide binding]; other site 441620000428 circadian clock protein KaiC; Reviewed; Region: PRK09302 441620000429 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441620000430 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441620000431 Walker A motif; other site 441620000432 Walker A motif; other site 441620000433 ATP binding site [chemical binding]; other site 441620000434 Walker B motif; other site 441620000435 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441620000436 ATP binding site [chemical binding]; other site 441620000437 Walker A motif; other site 441620000438 Walker B motif; other site 441620000439 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 441620000440 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 441620000441 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 441620000442 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 441620000443 Domain of unknown function (DUF892); Region: DUF892; pfam05974 441620000444 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 441620000445 PAS domain S-box; Region: sensory_box; TIGR00229 441620000446 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000447 putative active site [active] 441620000448 heme pocket [chemical binding]; other site 441620000449 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620000450 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620000451 metal binding site [ion binding]; metal-binding site 441620000452 active site 441620000453 I-site; other site 441620000454 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 441620000455 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620000456 dimer interface [polypeptide binding]; other site 441620000457 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 441620000458 putative CheW interface [polypeptide binding]; other site 441620000459 PilZ domain; Region: PilZ; pfam07238 441620000460 PAS fold; Region: PAS_4; pfam08448 441620000461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000462 PAS fold; Region: PAS_3; pfam08447 441620000463 putative active site [active] 441620000464 heme pocket [chemical binding]; other site 441620000465 PAS fold; Region: PAS_4; pfam08448 441620000466 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620000467 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620000468 dimer interface [polypeptide binding]; other site 441620000469 phosphorylation site [posttranslational modification] 441620000470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620000471 ATP binding site [chemical binding]; other site 441620000472 Mg2+ binding site [ion binding]; other site 441620000473 G-X-G motif; other site 441620000474 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620000475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620000476 active site 441620000477 phosphorylation site [posttranslational modification] 441620000478 intermolecular recognition site; other site 441620000479 dimerization interface [polypeptide binding]; other site 441620000480 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 441620000481 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000482 PAS domain; Region: PAS_9; pfam13426 441620000483 putative active site [active] 441620000484 heme pocket [chemical binding]; other site 441620000485 PAS fold; Region: PAS_4; pfam08448 441620000486 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000487 putative active site [active] 441620000488 heme pocket [chemical binding]; other site 441620000489 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000490 PAS fold; Region: PAS_3; pfam08447 441620000491 putative active site [active] 441620000492 heme pocket [chemical binding]; other site 441620000493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000494 PAS domain; Region: PAS_9; pfam13426 441620000495 putative active site [active] 441620000496 heme pocket [chemical binding]; other site 441620000497 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620000498 GAF domain; Region: GAF; pfam01590 441620000499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000500 PAS fold; Region: PAS_3; pfam08447 441620000501 putative active site [active] 441620000502 heme pocket [chemical binding]; other site 441620000503 PAS domain S-box; Region: sensory_box; TIGR00229 441620000504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000505 putative active site [active] 441620000506 heme pocket [chemical binding]; other site 441620000507 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620000508 dimer interface [polypeptide binding]; other site 441620000509 phosphorylation site [posttranslational modification] 441620000510 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 441620000511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620000512 ATP binding site [chemical binding]; other site 441620000513 Mg2+ binding site [ion binding]; other site 441620000514 G-X-G motif; other site 441620000515 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620000516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620000517 active site 441620000518 phosphorylation site [posttranslational modification] 441620000519 intermolecular recognition site; other site 441620000520 dimerization interface [polypeptide binding]; other site 441620000521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620000522 intermolecular recognition site; other site 441620000523 active site 441620000524 dimerization interface [polypeptide binding]; other site 441620000525 GAF domain; Region: GAF_3; pfam13492 441620000526 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620000527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620000528 dimer interface [polypeptide binding]; other site 441620000529 phosphorylation site [posttranslational modification] 441620000530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620000531 ATP binding site [chemical binding]; other site 441620000532 Mg2+ binding site [ion binding]; other site 441620000533 G-X-G motif; other site 441620000534 Response regulator receiver domain; Region: Response_reg; pfam00072 441620000535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620000536 active site 441620000537 phosphorylation site [posttranslational modification] 441620000538 intermolecular recognition site; other site 441620000539 dimerization interface [polypeptide binding]; other site 441620000540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620000541 dimer interface [polypeptide binding]; other site 441620000542 phosphorylation site [posttranslational modification] 441620000543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620000544 ATP binding site [chemical binding]; other site 441620000545 Mg2+ binding site [ion binding]; other site 441620000546 G-X-G motif; other site 441620000547 PAS fold; Region: PAS_4; pfam08448 441620000548 PAS domain; Region: PAS_9; pfam13426 441620000549 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000550 putative active site [active] 441620000551 heme pocket [chemical binding]; other site 441620000552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000553 PAS fold; Region: PAS_3; pfam08447 441620000554 putative active site [active] 441620000555 heme pocket [chemical binding]; other site 441620000556 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000557 PAS domain; Region: PAS_9; pfam13426 441620000558 putative active site [active] 441620000559 heme pocket [chemical binding]; other site 441620000560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620000561 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620000562 dimer interface [polypeptide binding]; other site 441620000563 phosphorylation site [posttranslational modification] 441620000564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620000565 ATP binding site [chemical binding]; other site 441620000566 Mg2+ binding site [ion binding]; other site 441620000567 G-X-G motif; other site 441620000568 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620000569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620000570 active site 441620000571 phosphorylation site [posttranslational modification] 441620000572 intermolecular recognition site; other site 441620000573 dimerization interface [polypeptide binding]; other site 441620000574 PAS fold; Region: PAS_3; pfam08447 441620000575 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 441620000576 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000577 putative active site [active] 441620000578 heme pocket [chemical binding]; other site 441620000579 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620000580 dimer interface [polypeptide binding]; other site 441620000581 phosphorylation site [posttranslational modification] 441620000582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620000583 ATP binding site [chemical binding]; other site 441620000584 G-X-G motif; other site 441620000585 Response regulator receiver domain; Region: Response_reg; pfam00072 441620000586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620000587 active site 441620000588 phosphorylation site [posttranslational modification] 441620000589 intermolecular recognition site; other site 441620000590 dimerization interface [polypeptide binding]; other site 441620000591 PAS fold; Region: PAS_4; pfam08448 441620000592 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 441620000593 photolyase PhrII; Region: phr2; TIGR00591 441620000594 DNA photolyase; Region: DNA_photolyase; pfam00875 441620000595 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 441620000596 Transposase, Mutator family; Region: Transposase_mut; pfam00872 441620000597 MULE transposase domain; Region: MULE; pfam10551 441620000598 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 441620000599 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 441620000600 active site 441620000601 nucleophile elbow; other site 441620000602 Patatin phospholipase; Region: DUF3734; pfam12536 441620000603 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 441620000604 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 441620000605 NAD binding site [chemical binding]; other site 441620000606 catalytic Zn binding site [ion binding]; other site 441620000607 structural Zn binding site [ion binding]; other site 441620000608 short chain dehydrogenase; Provisional; Region: PRK07109 441620000609 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 441620000610 putative NAD(P) binding site [chemical binding]; other site 441620000611 active site 441620000612 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 441620000613 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 441620000614 catalytic triad [active] 441620000615 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000616 PAS domain; Region: PAS_9; pfam13426 441620000617 putative active site [active] 441620000618 heme pocket [chemical binding]; other site 441620000619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620000620 HWE histidine kinase; Region: HWE_HK; pfam07536 441620000621 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 441620000622 Domain of unknown function (DUF892); Region: DUF892; pfam05974 441620000623 CHASE3 domain; Region: CHASE3; pfam05227 441620000624 PAS fold; Region: PAS_7; pfam12860 441620000625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620000626 dimer interface [polypeptide binding]; other site 441620000627 phosphorylation site [posttranslational modification] 441620000628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620000629 ATP binding site [chemical binding]; other site 441620000630 Mg2+ binding site [ion binding]; other site 441620000631 G-X-G motif; other site 441620000632 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620000633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620000634 active site 441620000635 phosphorylation site [posttranslational modification] 441620000636 intermolecular recognition site; other site 441620000637 dimerization interface [polypeptide binding]; other site 441620000638 GAF domain; Region: GAF; pfam01590 441620000639 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620000640 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000641 PAS domain; Region: PAS_9; pfam13426 441620000642 putative active site [active] 441620000643 heme pocket [chemical binding]; other site 441620000644 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000645 PAS domain; Region: PAS_9; pfam13426 441620000646 putative active site [active] 441620000647 heme pocket [chemical binding]; other site 441620000648 PAS fold; Region: PAS_3; pfam08447 441620000649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000650 PAS fold; Region: PAS_3; pfam08447 441620000651 putative active site [active] 441620000652 heme pocket [chemical binding]; other site 441620000653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620000654 HWE histidine kinase; Region: HWE_HK; pfam07536 441620000655 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441620000656 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 441620000657 ligand binding site [chemical binding]; other site 441620000658 flexible hinge region; other site 441620000659 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 441620000660 putative switch regulator; other site 441620000661 non-specific DNA interactions [nucleotide binding]; other site 441620000662 DNA binding site [nucleotide binding] 441620000663 sequence specific DNA binding site [nucleotide binding]; other site 441620000664 putative cAMP binding site [chemical binding]; other site 441620000665 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620000666 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620000667 metal binding site [ion binding]; metal-binding site 441620000668 active site 441620000669 I-site; other site 441620000670 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 441620000671 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 441620000672 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 441620000673 active site 441620000674 metal binding site [ion binding]; metal-binding site 441620000675 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 441620000676 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 441620000677 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 441620000678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620000679 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 441620000680 Walker A motif; other site 441620000681 ATP binding site [chemical binding]; other site 441620000682 Walker B motif; other site 441620000683 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 441620000684 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 441620000685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620000686 catalytic residue [active] 441620000687 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 441620000688 active site 441620000689 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 441620000690 IHF dimer interface [polypeptide binding]; other site 441620000691 IHF - DNA interface [nucleotide binding]; other site 441620000692 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 441620000693 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 441620000694 tandem repeat interface [polypeptide binding]; other site 441620000695 oligomer interface [polypeptide binding]; other site 441620000696 active site residues [active] 441620000697 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 441620000698 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 441620000699 RNA binding site [nucleotide binding]; other site 441620000700 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 441620000701 RNA binding site [nucleotide binding]; other site 441620000702 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 441620000703 RNA binding site [nucleotide binding]; other site 441620000704 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 441620000705 RNA binding site [nucleotide binding]; other site 441620000706 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 441620000707 RNA binding site [nucleotide binding]; other site 441620000708 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 441620000709 RNA binding site [nucleotide binding]; other site 441620000710 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 441620000711 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 441620000712 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 441620000713 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 441620000714 catalytic residues [active] 441620000715 Recombinase; Region: Recombinase; pfam07508 441620000716 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 441620000717 PBP superfamily domain; Region: PBP_like; pfam12727 441620000718 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 441620000719 Predicted membrane protein [Function unknown]; Region: COG2855 441620000720 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 441620000721 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 441620000722 minor groove reading motif; other site 441620000723 helix-hairpin-helix signature motif; other site 441620000724 substrate binding pocket [chemical binding]; other site 441620000725 active site 441620000726 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 441620000727 dimerization interface [polypeptide binding]; other site 441620000728 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620000729 dimer interface [polypeptide binding]; other site 441620000730 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 441620000731 putative CheW interface [polypeptide binding]; other site 441620000732 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 441620000733 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441620000734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620000735 Walker A/P-loop; other site 441620000736 ATP binding site [chemical binding]; other site 441620000737 Q-loop/lid; other site 441620000738 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441620000739 ABC transporter signature motif; other site 441620000740 Walker B; other site 441620000741 D-loop; other site 441620000742 ABC transporter; Region: ABC_tran_2; pfam12848 441620000743 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441620000744 Protein of unknown function (DUF419); Region: DUF419; pfam04237 441620000745 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 441620000746 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620000747 N-terminal plug; other site 441620000748 ligand-binding site [chemical binding]; other site 441620000749 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 441620000750 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 441620000751 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 441620000752 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 441620000753 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620000754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620000755 LysR substrate binding domain; Region: LysR_substrate; pfam03466 441620000756 dimerization interface [polypeptide binding]; other site 441620000757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 441620000758 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 441620000759 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 441620000760 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441620000761 catalytic loop [active] 441620000762 iron binding site [ion binding]; other site 441620000763 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441620000764 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441620000765 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 441620000766 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441620000767 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441620000768 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 441620000769 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620000770 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620000771 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 441620000772 Fusaric acid resistance protein family; Region: FUSC; pfam04632 441620000773 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441620000774 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 441620000775 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 441620000776 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 441620000777 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 441620000778 Tannase and feruloyl esterase; Region: Tannase; pfam07519 441620000779 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 441620000780 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 441620000781 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 441620000782 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441620000783 active site 441620000784 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 441620000785 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 441620000786 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 441620000787 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 441620000788 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 441620000789 putative active site [active] 441620000790 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 441620000791 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 441620000792 Cupin-like domain; Region: Cupin_8; pfam13621 441620000793 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 441620000794 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441620000795 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620000796 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 441620000797 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620000798 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 441620000799 O-Antigen ligase; Region: Wzy_C; pfam04932 441620000800 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 441620000801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620000802 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 441620000803 dimerization interface [polypeptide binding]; other site 441620000804 substrate binding pocket [chemical binding]; other site 441620000805 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 441620000806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620000807 NAD(P) binding site [chemical binding]; other site 441620000808 active site 441620000809 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 441620000810 TPP-binding site [chemical binding]; other site 441620000811 dimer interface [polypeptide binding]; other site 441620000812 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 441620000813 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 441620000814 PYR/PP interface [polypeptide binding]; other site 441620000815 dimer interface [polypeptide binding]; other site 441620000816 TPP binding site [chemical binding]; other site 441620000817 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 441620000818 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 441620000819 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 441620000820 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 441620000821 DctM-like transporters; Region: DctM; pfam06808 441620000822 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 441620000823 Porin subfamily; Region: Porin_2; pfam02530 441620000824 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 441620000825 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 441620000826 tetramer interface [polypeptide binding]; other site 441620000827 catalytic Zn binding site [ion binding]; other site 441620000828 NADP binding site [chemical binding]; other site 441620000829 Transposase, Mutator family; Region: Transposase_mut; pfam00872 441620000830 MULE transposase domain; Region: MULE; pfam10551 441620000831 RNA polymerase sigma factor; Provisional; Region: PRK12547 441620000832 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441620000833 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441620000834 DNA binding residues [nucleotide binding] 441620000835 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441620000836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620000837 non-specific DNA binding site [nucleotide binding]; other site 441620000838 salt bridge; other site 441620000839 sequence-specific DNA binding site [nucleotide binding]; other site 441620000840 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 441620000841 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 441620000842 Walker A/P-loop; other site 441620000843 ATP binding site [chemical binding]; other site 441620000844 Q-loop/lid; other site 441620000845 ABC transporter signature motif; other site 441620000846 Walker B; other site 441620000847 D-loop; other site 441620000848 H-loop/switch region; other site 441620000849 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 441620000850 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620000851 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620000852 transcriptional regulator ICP4; Provisional; Region: PHA03307 441620000853 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 441620000854 transcription termination factor Rho; Provisional; Region: PRK12678 441620000855 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 441620000856 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 441620000857 DXD motif; other site 441620000858 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 441620000859 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620000860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620000861 NAD(P) binding site [chemical binding]; other site 441620000862 active site 441620000863 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441620000864 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620000865 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 441620000866 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 441620000867 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 441620000868 putative ADP-binding pocket [chemical binding]; other site 441620000869 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 441620000870 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 441620000871 putative ADP-binding pocket [chemical binding]; other site 441620000872 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 441620000873 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441620000874 active site 441620000875 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441620000876 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 441620000877 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 441620000878 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 441620000879 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441620000880 active site 441620000881 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 441620000882 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 441620000883 putative ADP-binding pocket [chemical binding]; other site 441620000884 Methyltransferase domain; Region: Methyltransf_24; pfam13578 441620000885 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441620000886 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 441620000887 catalytic loop [active] 441620000888 iron binding site [ion binding]; other site 441620000889 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 441620000890 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 441620000891 [4Fe-4S] binding site [ion binding]; other site 441620000892 molybdopterin cofactor binding site; other site 441620000893 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 441620000894 molybdopterin cofactor binding site; other site 441620000895 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 441620000896 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 441620000897 putative dimer interface [polypeptide binding]; other site 441620000898 [2Fe-2S] cluster binding site [ion binding]; other site 441620000899 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 441620000900 SLBB domain; Region: SLBB; pfam10531 441620000901 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 441620000902 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 441620000903 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 441620000904 putative heme binding pocket [chemical binding]; other site 441620000905 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 441620000906 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 441620000907 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441620000908 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441620000909 DNA binding residues [nucleotide binding] 441620000910 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 441620000911 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 441620000912 Domain of unknown function DUF20; Region: UPF0118; pfam01594 441620000913 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 441620000914 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 441620000915 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 441620000916 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 441620000917 PAS domain; Region: PAS_9; pfam13426 441620000918 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 441620000919 CheB methylesterase; Region: CheB_methylest; pfam01339 441620000920 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 441620000921 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 441620000922 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 441620000923 PAS domain; Region: PAS_10; pfam13596 441620000924 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620000925 HWE histidine kinase; Region: HWE_HK; smart00911 441620000926 DDE superfamily endonuclease; Region: DDE_5; pfam13546 441620000927 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 441620000928 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620000929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620000930 ATP binding site [chemical binding]; other site 441620000931 G-X-G motif; other site 441620000932 Response regulator receiver domain; Region: Response_reg; pfam00072 441620000933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620000934 active site 441620000935 phosphorylation site [posttranslational modification] 441620000936 intermolecular recognition site; other site 441620000937 dimerization interface [polypeptide binding]; other site 441620000938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 441620000939 active site 441620000940 phosphorylation site [posttranslational modification] 441620000941 intermolecular recognition site; other site 441620000942 dimerization interface [polypeptide binding]; other site 441620000943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000944 PAS domain; Region: PAS_9; pfam13426 441620000945 putative active site [active] 441620000946 heme pocket [chemical binding]; other site 441620000947 PAS domain S-box; Region: sensory_box; TIGR00229 441620000948 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620000949 putative active site [active] 441620000950 heme pocket [chemical binding]; other site 441620000951 PAS fold; Region: PAS_4; pfam08448 441620000952 PAS domain S-box; Region: sensory_box; TIGR00229 441620000953 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 441620000954 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620000955 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620000956 HWE histidine kinase; Region: HWE_HK; smart00911 441620000957 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 441620000958 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 441620000959 putative heme binding pocket [chemical binding]; other site 441620000960 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 441620000961 putative heme binding pocket [chemical binding]; other site 441620000962 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 441620000963 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 441620000964 proposed catalytic triad [active] 441620000965 conserved cys residue [active] 441620000966 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 441620000967 classical (c) SDRs; Region: SDR_c; cd05233 441620000968 NAD(P) binding site [chemical binding]; other site 441620000969 active site 441620000970 Ferritin-like domain; Region: Ferritin; pfam00210 441620000971 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 441620000972 dimerization interface [polypeptide binding]; other site 441620000973 DPS ferroxidase diiron center [ion binding]; other site 441620000974 ion pore; other site 441620000975 methionine sulfoxide reductase A; Provisional; Region: PRK14054 441620000976 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 441620000977 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 441620000978 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 441620000979 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 441620000980 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 441620000981 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 441620000982 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 441620000983 Transposase; Region: DEDD_Tnp_IS110; pfam01548 441620000984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 441620000985 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 441620000986 Y-family of DNA polymerases; Region: PolY; cl12025 441620000987 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 441620000988 Catalytic site [active] 441620000989 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 441620000990 active site 441620000991 catalytic residues [active] 441620000992 DNA binding site [nucleotide binding] 441620000993 Int/Topo IB signature motif; other site 441620000994 Transposase, Mutator family; Region: Transposase_mut; pfam00872 441620000995 MULE transposase domain; Region: MULE; pfam10551 441620000996 putative transposase OrfB; Reviewed; Region: PHA02517 441620000997 HTH-like domain; Region: HTH_21; pfam13276 441620000998 Integrase core domain; Region: rve; pfam00665 441620000999 Integrase core domain; Region: rve_3; pfam13683 441620001000 Transposase; Region: HTH_Tnp_1; pfam01527 441620001001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620001002 ATP binding site [chemical binding]; other site 441620001003 G-X-G motif; other site 441620001004 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441620001005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620001006 active site 441620001007 phosphorylation site [posttranslational modification] 441620001008 intermolecular recognition site; other site 441620001009 dimerization interface [polypeptide binding]; other site 441620001010 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441620001011 DNA binding residues [nucleotide binding] 441620001012 dimerization interface [polypeptide binding]; other site 441620001013 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441620001014 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441620001015 active site 441620001016 Int/Topo IB signature motif; other site 441620001017 DNA binding site [nucleotide binding] 441620001018 recombination factor protein RarA; Reviewed; Region: PRK13342 441620001019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620001020 Walker A motif; other site 441620001021 ATP binding site [chemical binding]; other site 441620001022 Walker B motif; other site 441620001023 arginine finger; other site 441620001024 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 441620001025 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 441620001026 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 441620001027 active site 441620001028 Zn binding site [ion binding]; other site 441620001029 putative chaperone; Provisional; Region: PRK11678 441620001030 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 441620001031 nucleotide binding site [chemical binding]; other site 441620001032 putative NEF/HSP70 interaction site [polypeptide binding]; other site 441620001033 SBD interface [polypeptide binding]; other site 441620001034 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 441620001035 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441620001036 RNA binding surface [nucleotide binding]; other site 441620001037 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 441620001038 active site 441620001039 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 441620001040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441620001041 motif II; other site 441620001042 ATP12 chaperone protein; Region: ATP12; cl02228 441620001043 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 441620001044 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 441620001045 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 441620001046 tellurium resistance terB-like protein; Region: terB_like; cd07177 441620001047 metal binding site [ion binding]; metal-binding site 441620001048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441620001049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441620001050 ketol-acid reductoisomerase; Provisional; Region: PRK05479 441620001051 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 441620001052 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 441620001053 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 441620001054 Methyltransferase domain; Region: Methyltransf_24; pfam13578 441620001055 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 441620001056 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 441620001057 putative NAD(P) binding site [chemical binding]; other site 441620001058 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 441620001059 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 441620001060 tetramer interface [polypeptide binding]; other site 441620001061 heme binding pocket [chemical binding]; other site 441620001062 NADPH binding site [chemical binding]; other site 441620001063 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, MeaA-like subfamily; contains various methylmalonyl coenzyme A (CoA) mutase (MCM)-like proteins similar to the Streptomyces cinnamonensis MeaA, Methylobacterium extorquens MeaA...; Region: MM_CoA_mutase_MeaA; cd03681 441620001064 putative active site [active] 441620001065 putative substrate binding site [chemical binding]; other site 441620001066 putative coenzyme B12 binding site [chemical binding]; other site 441620001067 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 441620001068 B12 binding site [chemical binding]; other site 441620001069 cobalt ligand [ion binding]; other site 441620001070 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 441620001071 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 441620001072 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 441620001073 NADP binding site [chemical binding]; other site 441620001074 homodimer interface [polypeptide binding]; other site 441620001075 active site 441620001076 substrate binding site [chemical binding]; other site 441620001077 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441620001078 dimerization interface [polypeptide binding]; other site 441620001079 putative DNA binding site [nucleotide binding]; other site 441620001080 putative Zn2+ binding site [ion binding]; other site 441620001081 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 441620001082 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 441620001083 active site 441620001084 HIGH motif; other site 441620001085 dimer interface [polypeptide binding]; other site 441620001086 KMSKS motif; other site 441620001087 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 441620001088 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 441620001089 substrate binding site [chemical binding]; other site 441620001090 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 441620001091 putative substrate binding pocket [chemical binding]; other site 441620001092 AC domain interface; other site 441620001093 catalytic triad [active] 441620001094 AB domain interface; other site 441620001095 interchain disulfide; other site 441620001096 membrane ATPase/protein kinase; Provisional; Region: PRK09435 441620001097 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 441620001098 Walker A; other site 441620001099 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 441620001100 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 441620001101 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 441620001102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 441620001103 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441620001104 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 441620001105 active site 441620001106 metal binding site [ion binding]; metal-binding site 441620001107 DNA binding site [nucleotide binding] 441620001108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620001109 Walker A/P-loop; other site 441620001110 ATP binding site [chemical binding]; other site 441620001111 Q-loop/lid; other site 441620001112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620001113 ABC transporter signature motif; other site 441620001114 Walker B; other site 441620001115 D-loop; other site 441620001116 H-loop/switch region; other site 441620001117 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 441620001118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620001119 putative substrate translocation pore; other site 441620001120 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 441620001121 Methyltransferase domain; Region: Methyltransf_11; pfam08241 441620001122 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 441620001123 Domain of unknown function (DUF427); Region: DUF427; pfam04248 441620001124 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 441620001125 active site 441620001126 8-oxo-dGMP binding site [chemical binding]; other site 441620001127 nudix motif; other site 441620001128 metal binding site [ion binding]; metal-binding site 441620001129 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 441620001130 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 441620001131 heterotetramer interface [polypeptide binding]; other site 441620001132 active site pocket [active] 441620001133 cleavage site 441620001134 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 441620001135 catalytic residues [active] 441620001136 dimer interface [polypeptide binding]; other site 441620001137 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 441620001138 Proline dehydrogenase; Region: Pro_dh; pfam01619 441620001139 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 441620001140 Glutamate binding site [chemical binding]; other site 441620001141 NAD binding site [chemical binding]; other site 441620001142 catalytic residues [active] 441620001143 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 441620001144 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 441620001145 Part of AAA domain; Region: AAA_19; pfam13245 441620001146 Family description; Region: UvrD_C_2; pfam13538 441620001147 PhoH-like protein; Region: PhoH; pfam02562 441620001148 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 441620001149 amphipathic channel; other site 441620001150 Asn-Pro-Ala signature motifs; other site 441620001151 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 441620001152 active site 441620001153 catalytic site [active] 441620001154 substrate binding site [chemical binding]; other site 441620001155 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 441620001156 Cupin; Region: Cupin_1; smart00835 441620001157 Cupin; Region: Cupin_1; smart00835 441620001158 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 441620001159 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 441620001160 metal binding triad; other site 441620001161 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 441620001162 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 441620001163 metal binding triad; other site 441620001164 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 441620001165 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441620001166 dimerization interface [polypeptide binding]; other site 441620001167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620001168 dimer interface [polypeptide binding]; other site 441620001169 phosphorylation site [posttranslational modification] 441620001170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620001171 ATP binding site [chemical binding]; other site 441620001172 Mg2+ binding site [ion binding]; other site 441620001173 G-X-G motif; other site 441620001174 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441620001175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620001176 active site 441620001177 phosphorylation site [posttranslational modification] 441620001178 intermolecular recognition site; other site 441620001179 dimerization interface [polypeptide binding]; other site 441620001180 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620001181 DNA binding site [nucleotide binding] 441620001182 OsmC-like protein; Region: OsmC; pfam02566 441620001183 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441620001184 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441620001185 Walker A/P-loop; other site 441620001186 ATP binding site [chemical binding]; other site 441620001187 Q-loop/lid; other site 441620001188 ABC transporter signature motif; other site 441620001189 Walker B; other site 441620001190 D-loop; other site 441620001191 H-loop/switch region; other site 441620001192 Protein of unknown function DUF86; Region: DUF86; cl01031 441620001193 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 441620001194 active site 441620001195 NTP binding site [chemical binding]; other site 441620001196 metal binding triad [ion binding]; metal-binding site 441620001197 antibiotic binding site [chemical binding]; other site 441620001198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 441620001199 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 441620001200 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 441620001201 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 441620001202 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441620001203 substrate binding pocket [chemical binding]; other site 441620001204 membrane-bound complex binding site; other site 441620001205 PII uridylyl-transferase; Provisional; Region: PRK05092 441620001206 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 441620001207 metal binding triad; other site 441620001208 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 441620001209 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441620001210 Zn2+ binding site [ion binding]; other site 441620001211 Mg2+ binding site [ion binding]; other site 441620001212 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 441620001213 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 441620001214 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 441620001215 dimer interface [polypeptide binding]; other site 441620001216 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 441620001217 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 441620001218 Protein of unknown function (DUF497); Region: DUF497; cl01108 441620001219 prephenate dehydratase; Provisional; Region: PRK11899 441620001220 Prephenate dehydratase; Region: PDT; pfam00800 441620001221 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 441620001222 putative L-Phe binding site [chemical binding]; other site 441620001223 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441620001224 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 441620001225 active site 441620001226 Cytochrome c2 [Energy production and conversion]; Region: COG3474 441620001227 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 441620001228 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 441620001229 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 441620001230 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 441620001231 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 441620001232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620001233 dimer interface [polypeptide binding]; other site 441620001234 conserved gate region; other site 441620001235 putative PBP binding loops; other site 441620001236 ABC-ATPase subunit interface; other site 441620001237 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 441620001238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441620001239 Coenzyme A binding pocket [chemical binding]; other site 441620001240 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 441620001241 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441620001242 acyl-activating enzyme (AAE) consensus motif; other site 441620001243 AMP binding site [chemical binding]; other site 441620001244 active site 441620001245 CoA binding site [chemical binding]; other site 441620001246 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 441620001247 putative metal binding site; other site 441620001248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441620001249 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 441620001250 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441620001251 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620001252 Domain of unknown function DUF302; Region: DUF302; cl01364 441620001253 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 441620001254 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 441620001255 potential catalytic triad [active] 441620001256 conserved cys residue [active] 441620001257 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 441620001258 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 441620001259 putative dimer interface [polypeptide binding]; other site 441620001260 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 441620001261 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441620001262 FeS/SAM binding site; other site 441620001263 HemN C-terminal domain; Region: HemN_C; pfam06969 441620001264 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 441620001265 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 441620001266 trimer interface [polypeptide binding]; other site 441620001267 active site 441620001268 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 441620001269 trimer interface [polypeptide binding]; other site 441620001270 active site 441620001271 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 441620001272 acetylornithine deacetylase; Provisional; Region: PRK07522 441620001273 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 441620001274 metal binding site [ion binding]; metal-binding site 441620001275 putative dimer interface [polypeptide binding]; other site 441620001276 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 441620001277 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 441620001278 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 441620001279 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 441620001280 putative MPT binding site; other site 441620001281 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 441620001282 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 441620001283 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 441620001284 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 441620001285 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 441620001286 ABC-2 type transporter; Region: ABC2_membrane; cl17235 441620001287 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 441620001288 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441620001289 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 441620001290 Walker A/P-loop; other site 441620001291 ATP binding site [chemical binding]; other site 441620001292 Q-loop/lid; other site 441620001293 ABC transporter signature motif; other site 441620001294 Walker B; other site 441620001295 D-loop; other site 441620001296 H-loop/switch region; other site 441620001297 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 441620001298 4Fe-4S binding domain; Region: Fer4; pfam00037 441620001299 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 441620001300 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 441620001301 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 441620001302 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 441620001303 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 441620001304 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 441620001305 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 441620001306 [4Fe-4S] binding site [ion binding]; other site 441620001307 molybdopterin cofactor binding site; other site 441620001308 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 441620001309 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 441620001310 molybdopterin cofactor binding site; other site 441620001311 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 441620001312 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 441620001313 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 441620001314 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 441620001315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441620001316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441620001317 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 441620001318 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441620001319 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620001320 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620001321 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 441620001322 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 441620001323 ribonuclease PH; Reviewed; Region: rph; PRK00173 441620001324 Ribonuclease PH; Region: RNase_PH_bact; cd11362 441620001325 hexamer interface [polypeptide binding]; other site 441620001326 active site 441620001327 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 441620001328 active site 441620001329 dimerization interface [polypeptide binding]; other site 441620001330 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 441620001331 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441620001332 FeS/SAM binding site; other site 441620001333 HemN C-terminal domain; Region: HemN_C; pfam06969 441620001334 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 441620001335 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 441620001336 putative ligand binding site [chemical binding]; other site 441620001337 Predicted methyltransferases [General function prediction only]; Region: COG0313 441620001338 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 441620001339 putative SAM binding site [chemical binding]; other site 441620001340 putative homodimer interface [polypeptide binding]; other site 441620001341 hypothetical protein; Provisional; Region: PRK14679 441620001342 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620001343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620001344 active site 441620001345 phosphorylation site [posttranslational modification] 441620001346 intermolecular recognition site; other site 441620001347 dimerization interface [polypeptide binding]; other site 441620001348 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 441620001349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 441620001350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 441620001351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 441620001352 DDE superfamily endonuclease; Region: DDE_3; pfam13358 441620001353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 441620001354 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 441620001355 Isochorismatase family; Region: Isochorismatase; pfam00857 441620001356 dimer interface [polypeptide binding]; other site 441620001357 catalytic triad [active] 441620001358 conserved cis-peptide bond; other site 441620001359 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441620001360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 441620001361 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441620001362 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 441620001363 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 441620001364 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 441620001365 active site 441620001366 Zn binding site [ion binding]; other site 441620001367 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 441620001368 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 441620001369 Potassium binding sites [ion binding]; other site 441620001370 Cesium cation binding sites [ion binding]; other site 441620001371 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441620001372 metal-binding site [ion binding] 441620001373 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 441620001374 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 441620001375 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 441620001376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620001377 active site 441620001378 phosphorylation site [posttranslational modification] 441620001379 intermolecular recognition site; other site 441620001380 dimerization interface [polypeptide binding]; other site 441620001381 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 441620001382 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 441620001383 active site 441620001384 Riboflavin kinase; Region: Flavokinase; pfam01687 441620001385 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 441620001386 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 441620001387 dimerization interface [polypeptide binding]; other site 441620001388 ligand binding site [chemical binding]; other site 441620001389 NADP binding site [chemical binding]; other site 441620001390 catalytic site [active] 441620001391 Bacterial SH3 domain; Region: SH3_4; pfam06347 441620001392 Bacterial SH3 domain; Region: SH3_4; pfam06347 441620001393 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 441620001394 metal binding site 2 [ion binding]; metal-binding site 441620001395 putative DNA binding helix; other site 441620001396 metal binding site 1 [ion binding]; metal-binding site 441620001397 dimer interface [polypeptide binding]; other site 441620001398 structural Zn2+ binding site [ion binding]; other site 441620001399 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 441620001400 active site 1 [active] 441620001401 dimer interface [polypeptide binding]; other site 441620001402 active site 2 [active] 441620001403 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 441620001404 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 441620001405 dimer interface [polypeptide binding]; other site 441620001406 active site 441620001407 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 441620001408 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 441620001409 NAD binding site [chemical binding]; other site 441620001410 homotetramer interface [polypeptide binding]; other site 441620001411 homodimer interface [polypeptide binding]; other site 441620001412 substrate binding site [chemical binding]; other site 441620001413 active site 441620001414 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 441620001415 Predicted membrane protein [Function unknown]; Region: COG2259 441620001416 hypothetical protein; Provisional; Region: PRK13663 441620001417 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 441620001418 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 441620001419 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 441620001420 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 441620001421 PAS domain S-box; Region: sensory_box; TIGR00229 441620001422 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620001423 putative active site [active] 441620001424 heme pocket [chemical binding]; other site 441620001425 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620001426 Histidine kinase; Region: HisKA_2; pfam07568 441620001427 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 441620001428 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620001429 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 441620001430 putative active site [active] 441620001431 heme pocket [chemical binding]; other site 441620001432 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620001433 putative active site [active] 441620001434 heme pocket [chemical binding]; other site 441620001435 GAF domain; Region: GAF; pfam01590 441620001436 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620001437 PAS fold; Region: PAS_4; pfam08448 441620001438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620001439 putative active site [active] 441620001440 heme pocket [chemical binding]; other site 441620001441 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 441620001442 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620001443 putative active site [active] 441620001444 heme pocket [chemical binding]; other site 441620001445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620001446 ATP binding site [chemical binding]; other site 441620001447 Mg2+ binding site [ion binding]; other site 441620001448 G-X-G motif; other site 441620001449 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620001450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620001451 active site 441620001452 phosphorylation site [posttranslational modification] 441620001453 intermolecular recognition site; other site 441620001454 dimerization interface [polypeptide binding]; other site 441620001455 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 441620001456 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 441620001457 dimer interface [polypeptide binding]; other site 441620001458 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 441620001459 active site 441620001460 metal binding site [ion binding]; metal-binding site 441620001461 glutathione binding site [chemical binding]; other site 441620001462 aminopeptidase N; Provisional; Region: pepN; PRK14015 441620001463 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 441620001464 Zn binding site [ion binding]; other site 441620001465 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 441620001466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620001467 PAS fold; Region: PAS_3; pfam08447 441620001468 putative active site [active] 441620001469 heme pocket [chemical binding]; other site 441620001470 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 441620001471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620001472 dimer interface [polypeptide binding]; other site 441620001473 phosphorylation site [posttranslational modification] 441620001474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620001475 ATP binding site [chemical binding]; other site 441620001476 Mg2+ binding site [ion binding]; other site 441620001477 G-X-G motif; other site 441620001478 Arginase family; Region: Arginase; cd09989 441620001479 active site 441620001480 Mn binding site [ion binding]; other site 441620001481 oligomer interface [polypeptide binding]; other site 441620001482 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 441620001483 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 441620001484 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 441620001485 PilZ domain; Region: PilZ; cl01260 441620001486 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 441620001487 ATP-NAD kinase; Region: NAD_kinase; pfam01513 441620001488 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 441620001489 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 441620001490 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 441620001491 putative RNA binding site [nucleotide binding]; other site 441620001492 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 441620001493 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 441620001494 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 441620001495 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 441620001496 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441620001497 catalytic residue [active] 441620001498 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 441620001499 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 441620001500 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 441620001501 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 441620001502 homotetramer interface [polypeptide binding]; other site 441620001503 NAD(P) binding site [chemical binding]; other site 441620001504 homodimer interface [polypeptide binding]; other site 441620001505 active site 441620001506 acyl carrier protein; Provisional; Region: acpP; PRK00982 441620001507 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 441620001508 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 441620001509 dimer interface [polypeptide binding]; other site 441620001510 active site 441620001511 YceG-like family; Region: YceG; pfam02618 441620001512 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 441620001513 dimerization interface [polypeptide binding]; other site 441620001514 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 441620001515 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 441620001516 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 441620001517 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 441620001518 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 441620001519 Acetokinase family; Region: Acetate_kinase; cl17229 441620001520 propionate/acetate kinase; Provisional; Region: PRK12379 441620001521 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441620001522 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 441620001523 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620001524 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441620001525 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 441620001526 Walker A/P-loop; other site 441620001527 ATP binding site [chemical binding]; other site 441620001528 Q-loop/lid; other site 441620001529 ABC transporter signature motif; other site 441620001530 Walker B; other site 441620001531 D-loop; other site 441620001532 H-loop/switch region; other site 441620001533 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441620001534 Walker A/P-loop; other site 441620001535 ATP binding site [chemical binding]; other site 441620001536 Q-loop/lid; other site 441620001537 ABC transporter signature motif; other site 441620001538 Walker B; other site 441620001539 D-loop; other site 441620001540 H-loop/switch region; other site 441620001541 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 441620001542 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 441620001543 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 441620001544 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 441620001545 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 441620001546 putative phosphoketolase; Provisional; Region: PRK05261 441620001547 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 441620001548 TPP-binding site; other site 441620001549 XFP C-terminal domain; Region: XFP_C; pfam09363 441620001550 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 441620001551 GAF domain; Region: GAF; pfam01590 441620001552 Phytochrome region; Region: PHY; pfam00360 441620001553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620001554 dimer interface [polypeptide binding]; other site 441620001555 phosphorylation site [posttranslational modification] 441620001556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620001557 ATP binding site [chemical binding]; other site 441620001558 Mg2+ binding site [ion binding]; other site 441620001559 G-X-G motif; other site 441620001560 Response regulator receiver domain; Region: Response_reg; pfam00072 441620001561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620001562 active site 441620001563 phosphorylation site [posttranslational modification] 441620001564 intermolecular recognition site; other site 441620001565 dimerization interface [polypeptide binding]; other site 441620001566 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620001567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620001568 active site 441620001569 phosphorylation site [posttranslational modification] 441620001570 intermolecular recognition site; other site 441620001571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620001572 dimer interface [polypeptide binding]; other site 441620001573 phosphorylation site [posttranslational modification] 441620001574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620001575 ATP binding site [chemical binding]; other site 441620001576 Mg2+ binding site [ion binding]; other site 441620001577 G-X-G motif; other site 441620001578 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620001579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620001580 active site 441620001581 phosphorylation site [posttranslational modification] 441620001582 intermolecular recognition site; other site 441620001583 dimerization interface [polypeptide binding]; other site 441620001584 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 441620001585 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 441620001586 Walker A/P-loop; other site 441620001587 ATP binding site [chemical binding]; other site 441620001588 Q-loop/lid; other site 441620001589 ABC transporter signature motif; other site 441620001590 Walker B; other site 441620001591 D-loop; other site 441620001592 H-loop/switch region; other site 441620001593 TOBE domain; Region: TOBE_2; pfam08402 441620001594 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 441620001595 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 441620001596 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 441620001597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620001598 ABC-ATPase subunit interface; other site 441620001599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620001600 putative PBP binding loops; other site 441620001601 dimer interface [polypeptide binding]; other site 441620001602 ABC-ATPase subunit interface; other site 441620001603 CysZ-like protein; Reviewed; Region: PRK12768 441620001604 Galactose oxidase, central domain; Region: Kelch_3; cl02701 441620001605 Kelch motif; Region: Kelch_6; pfam13964 441620001606 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 441620001607 Kelch domain; Region: Kelch; smart00612 441620001608 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 441620001609 Kelch domain; Region: Kelch; smart00612 441620001610 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 441620001611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 441620001612 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 441620001613 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441620001614 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441620001615 ligand binding site [chemical binding]; other site 441620001616 flexible hinge region; other site 441620001617 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 441620001618 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 441620001619 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 441620001620 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 441620001621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620001622 dimer interface [polypeptide binding]; other site 441620001623 conserved gate region; other site 441620001624 putative PBP binding loops; other site 441620001625 ABC-ATPase subunit interface; other site 441620001626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620001627 dimer interface [polypeptide binding]; other site 441620001628 conserved gate region; other site 441620001629 putative PBP binding loops; other site 441620001630 ABC-ATPase subunit interface; other site 441620001631 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 441620001632 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 441620001633 Walker A/P-loop; other site 441620001634 ATP binding site [chemical binding]; other site 441620001635 Q-loop/lid; other site 441620001636 ABC transporter signature motif; other site 441620001637 Walker B; other site 441620001638 D-loop; other site 441620001639 H-loop/switch region; other site 441620001640 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 441620001641 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 441620001642 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 441620001643 minor groove reading motif; other site 441620001644 helix-hairpin-helix signature motif; other site 441620001645 substrate binding pocket [chemical binding]; other site 441620001646 active site 441620001647 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 441620001648 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 441620001649 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 441620001650 ATP binding site [chemical binding]; other site 441620001651 active site 441620001652 substrate binding site [chemical binding]; other site 441620001653 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 441620001654 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 441620001655 Probable Catalytic site; other site 441620001656 metal-binding site 441620001657 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441620001658 active site 441620001659 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 441620001660 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 441620001661 Probable Catalytic site; other site 441620001662 metal-binding site 441620001663 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 441620001664 Protein of unknown function DUF45; Region: DUF45; pfam01863 441620001665 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 441620001666 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 441620001667 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620001668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620001669 dimer interface [polypeptide binding]; other site 441620001670 phosphorylation site [posttranslational modification] 441620001671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620001672 ATP binding site [chemical binding]; other site 441620001673 Mg2+ binding site [ion binding]; other site 441620001674 G-X-G motif; other site 441620001675 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 441620001676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620001677 active site 441620001678 phosphorylation site [posttranslational modification] 441620001679 intermolecular recognition site; other site 441620001680 dimerization interface [polypeptide binding]; other site 441620001681 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 441620001682 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 441620001683 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 441620001684 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 441620001685 putative active site [active] 441620001686 catalytic triad [active] 441620001687 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441620001688 active site 441620001689 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 441620001690 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 441620001691 active site 441620001692 dimerization interface [polypeptide binding]; other site 441620001693 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 441620001694 active site 441620001695 pyrophosphate binding site [ion binding]; other site 441620001696 thiamine phosphate binding site [chemical binding]; other site 441620001697 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 441620001698 ThiS interaction site; other site 441620001699 putative active site [active] 441620001700 tetramer interface [polypeptide binding]; other site 441620001701 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 441620001702 thiS-thiF/thiG interaction site; other site 441620001703 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 441620001704 hydroxyglutarate oxidase; Provisional; Region: PRK11728 441620001705 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 441620001706 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620001707 dimer interface [polypeptide binding]; other site 441620001708 putative CheW interface [polypeptide binding]; other site 441620001709 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 441620001710 cyclase homology domain; Region: CHD; cd07302 441620001711 nucleotidyl binding site; other site 441620001712 metal binding site [ion binding]; metal-binding site 441620001713 dimer interface [polypeptide binding]; other site 441620001714 Helix-turn-helix domain; Region: HTH_18; pfam12833 441620001715 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 441620001716 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 441620001717 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 441620001718 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 441620001719 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441620001720 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 441620001721 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441620001722 DNA binding residues [nucleotide binding] 441620001723 DNA primase; Validated; Region: dnaG; PRK05667 441620001724 CHC2 zinc finger; Region: zf-CHC2; pfam01807 441620001725 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 441620001726 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 441620001727 active site 441620001728 metal binding site [ion binding]; metal-binding site 441620001729 interdomain interaction site; other site 441620001730 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 441620001731 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 441620001732 Major royal jelly protein; Region: MRJP; pfam03022 441620001733 Yqey-like protein; Region: YqeY; pfam09424 441620001734 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 441620001735 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 441620001736 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 441620001737 catalytic site [active] 441620001738 subunit interface [polypeptide binding]; other site 441620001739 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 441620001740 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 441620001741 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 441620001742 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 441620001743 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 441620001744 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441620001745 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 441620001746 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12692 441620001747 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 441620001748 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441620001749 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 441620001750 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 441620001751 flagellar basal body P-ring protein; Reviewed; Region: flgI; PRK12789 441620001752 Flagellar P-ring protein; Region: FlgI; pfam02119 441620001753 Uncharacterized conserved protein [Function unknown]; Region: COG3334 441620001754 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788 441620001755 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 441620001756 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 441620001757 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK12783 441620001758 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 441620001759 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 441620001760 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 441620001761 flagellar motor protein MotB; Validated; Region: motB; PRK05996 441620001762 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 441620001763 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 441620001764 ligand binding site [chemical binding]; other site 441620001765 chemotaxis protein; Reviewed; Region: PRK12798 441620001766 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 441620001767 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 441620001768 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441620001769 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441620001770 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 441620001771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620001772 active site 441620001773 dimerization interface [polypeptide binding]; other site 441620001774 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620001775 DNA binding site [nucleotide binding] 441620001776 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK13109 441620001777 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 441620001778 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 441620001779 FliG C-terminal domain; Region: FliG_C; pfam01706 441620001780 flagellar motor switch protein FliN; Region: fliN; TIGR02480 441620001781 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 441620001782 Flagellar motor switch protein FliM; Region: FliM; pfam02154 441620001783 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 441620001784 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 441620001785 flagellar motor protein MotA; Validated; Region: PRK09110 441620001786 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 441620001787 active site 441620001788 HslU subunit interaction site [polypeptide binding]; other site 441620001789 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 441620001790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620001791 Walker A motif; other site 441620001792 ATP binding site [chemical binding]; other site 441620001793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620001794 Walker B motif; other site 441620001795 arginine finger; other site 441620001796 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 441620001797 threonine and homoserine efflux system; Provisional; Region: PRK10532 441620001798 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 441620001799 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 441620001800 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 441620001801 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 441620001802 [2Fe-2S] cluster binding site [ion binding]; other site 441620001803 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 441620001804 hydrophobic ligand binding site; other site 441620001805 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 441620001806 signal recognition particle protein; Provisional; Region: PRK10867 441620001807 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 441620001808 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 441620001809 P loop; other site 441620001810 GTP binding site [chemical binding]; other site 441620001811 Signal peptide binding domain; Region: SRP_SPB; pfam02978 441620001812 chorismate mutase; Provisional; Region: PRK09239 441620001813 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 441620001814 RimM N-terminal domain; Region: RimM; pfam01782 441620001815 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 441620001816 PRC-barrel domain; Region: PRC; pfam05239 441620001817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620001818 S-adenosylmethionine binding site [chemical binding]; other site 441620001819 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 441620001820 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 441620001821 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441620001822 catalytic residue [active] 441620001823 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 441620001824 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 441620001825 ligand binding site [chemical binding]; other site 441620001826 NAD binding site [chemical binding]; other site 441620001827 dimerization interface [polypeptide binding]; other site 441620001828 catalytic site [active] 441620001829 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 441620001830 putative L-serine binding site [chemical binding]; other site 441620001831 Domain of unknown function (DUF1902); Region: DUF1902; pfam08972 441620001832 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 441620001833 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 441620001834 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 441620001835 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 441620001836 putative efflux protein, MATE family; Region: matE; TIGR00797 441620001837 cation binding site [ion binding]; other site 441620001838 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 441620001839 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 441620001840 Walker A/P-loop; other site 441620001841 ATP binding site [chemical binding]; other site 441620001842 Q-loop/lid; other site 441620001843 ABC transporter signature motif; other site 441620001844 Walker B; other site 441620001845 D-loop; other site 441620001846 H-loop/switch region; other site 441620001847 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 441620001848 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 441620001849 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620001850 N-terminal plug; other site 441620001851 ligand-binding site [chemical binding]; other site 441620001852 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 441620001853 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 441620001854 AAA domain; Region: AAA_30; pfam13604 441620001855 Family description; Region: UvrD_C_2; pfam13538 441620001856 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 441620001857 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441620001858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620001859 homodimer interface [polypeptide binding]; other site 441620001860 catalytic residue [active] 441620001861 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441620001862 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620001863 DNA binding site [nucleotide binding] 441620001864 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 441620001865 PilZ domain; Region: PilZ; pfam07238 441620001866 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 441620001867 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 441620001868 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 441620001869 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 441620001870 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 441620001871 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441620001872 Walker A motif; other site 441620001873 ATP binding site [chemical binding]; other site 441620001874 Walker B motif; other site 441620001875 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 441620001876 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 441620001877 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 441620001878 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441620001879 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 441620001880 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 441620001881 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 441620001882 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 441620001883 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 441620001884 Flagellar protein FlaF; Region: FlaF; pfam07309 441620001885 flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794 441620001886 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 441620001887 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 441620001888 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK12781 441620001889 flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792 441620001890 FHIPEP family; Region: FHIPEP; pfam00771 441620001891 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK12780 441620001892 Rod binding protein; Region: Rod-binding; pfam10135 441620001893 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 441620001894 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441620001895 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 441620001896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620001897 putative active site [active] 441620001898 heme pocket [chemical binding]; other site 441620001899 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620001900 dimer interface [polypeptide binding]; other site 441620001901 phosphorylation site [posttranslational modification] 441620001902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620001903 ATP binding site [chemical binding]; other site 441620001904 Mg2+ binding site [ion binding]; other site 441620001905 G-X-G motif; other site 441620001906 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 441620001907 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 441620001908 Transglycosylase; Region: Transgly; pfam00912 441620001909 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 441620001910 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 441620001911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620001912 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 441620001913 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 441620001914 dimerization interface [polypeptide binding]; other site 441620001915 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 441620001916 AMP nucleosidase; Provisional; Region: PRK08292 441620001917 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 441620001918 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 441620001919 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 441620001920 homodimer interaction site [polypeptide binding]; other site 441620001921 cofactor binding site; other site 441620001922 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 441620001923 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 441620001924 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 441620001925 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 441620001926 putative active site [active] 441620001927 Zn binding site [ion binding]; other site 441620001928 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 441620001929 ligand binding site; other site 441620001930 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 441620001931 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 441620001932 ethanolamine permease; Region: 2A0305; TIGR00908 441620001933 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 441620001934 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 441620001935 catalytic triad [active] 441620001936 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 441620001937 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 441620001938 active site 441620001939 catalytic tetrad [active] 441620001940 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 441620001941 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441620001942 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441620001943 arsenical pump membrane protein; Provisional; Region: PRK15445 441620001944 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 441620001945 transmembrane helices; other site 441620001946 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 441620001947 ArsC family; Region: ArsC; pfam03960 441620001948 catalytic residues [active] 441620001949 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441620001950 dimerization interface [polypeptide binding]; other site 441620001951 putative DNA binding site [nucleotide binding]; other site 441620001952 putative Zn2+ binding site [ion binding]; other site 441620001953 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 441620001954 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 441620001955 Predicted membrane protein [Function unknown]; Region: COG1238 441620001956 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 441620001957 Putative ParB-like nuclease; Region: ParBc_2; cl17538 441620001958 EVE domain; Region: EVE; pfam01878 441620001959 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 441620001960 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 441620001961 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 441620001962 PAS domain; Region: PAS_9; pfam13426 441620001963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620001964 putative active site [active] 441620001965 heme pocket [chemical binding]; other site 441620001966 PAS domain; Region: PAS_9; pfam13426 441620001967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620001968 putative active site [active] 441620001969 heme pocket [chemical binding]; other site 441620001970 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441620001971 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620001972 dimer interface [polypeptide binding]; other site 441620001973 putative CheW interface [polypeptide binding]; other site 441620001974 UGMP family protein; Validated; Region: PRK09604 441620001975 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 441620001976 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 441620001977 active site 441620001978 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 441620001979 HemY protein N-terminus; Region: HemY_N; pfam07219 441620001980 DEAD/DEAH box helicase; Region: DEAD; pfam00270 441620001981 ATP binding site [chemical binding]; other site 441620001982 putative Mg++ binding site [ion binding]; other site 441620001983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441620001984 nucleotide binding region [chemical binding]; other site 441620001985 ATP-binding site [chemical binding]; other site 441620001986 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 441620001987 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 441620001988 gating phenylalanine in ion channel; other site 441620001989 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 441620001990 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441620001991 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441620001992 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441620001993 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441620001994 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 441620001995 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441620001996 catalytic loop [active] 441620001997 iron binding site [ion binding]; other site 441620001998 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441620001999 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 441620002000 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 441620002001 putative NAD(P) binding site [chemical binding]; other site 441620002002 dimer interface [polypeptide binding]; other site 441620002003 EamA-like transporter family; Region: EamA; pfam00892 441620002004 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 441620002005 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620002006 LysR substrate binding domain; Region: LysR_substrate; pfam03466 441620002007 dimerization interface [polypeptide binding]; other site 441620002008 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 441620002009 classical (c) SDRs; Region: SDR_c; cd05233 441620002010 NAD(P) binding site [chemical binding]; other site 441620002011 active site 441620002012 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 441620002013 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 441620002014 conserved cys residue [active] 441620002015 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441620002016 Caspase domain; Region: Peptidase_C14; pfam00656 441620002017 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 441620002018 Sel1-like repeats; Region: SEL1; smart00671 441620002019 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 441620002020 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 441620002021 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 441620002022 oligomeric interface; other site 441620002023 putative active site [active] 441620002024 homodimer interface [polypeptide binding]; other site 441620002025 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 441620002026 ligand binding site [chemical binding]; other site 441620002027 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 441620002028 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 441620002029 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 441620002030 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 441620002031 RNA binding site [nucleotide binding]; other site 441620002032 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 441620002033 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 441620002034 Walker A/P-loop; other site 441620002035 ATP binding site [chemical binding]; other site 441620002036 Q-loop/lid; other site 441620002037 ABC transporter signature motif; other site 441620002038 Walker B; other site 441620002039 D-loop; other site 441620002040 H-loop/switch region; other site 441620002041 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 441620002042 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 441620002043 FHIPEP family; Region: FHIPEP; pfam00771 441620002044 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 441620002045 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441620002046 dimerization interface [polypeptide binding]; other site 441620002047 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620002048 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 441620002049 dimer interface [polypeptide binding]; other site 441620002050 putative CheW interface [polypeptide binding]; other site 441620002051 Predicted integral membrane protein [Function unknown]; Region: COG0392 441620002052 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 441620002053 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 441620002054 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 441620002055 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 441620002056 Walker A motif/ATP binding site; other site 441620002057 Walker B motif; other site 441620002058 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441620002059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620002060 active site 441620002061 phosphorylation site [posttranslational modification] 441620002062 intermolecular recognition site; other site 441620002063 dimerization interface [polypeptide binding]; other site 441620002064 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620002065 DNA binding site [nucleotide binding] 441620002066 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 441620002067 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 441620002068 trimer interface [polypeptide binding]; other site 441620002069 active site 441620002070 substrate binding site [chemical binding]; other site 441620002071 CoA binding site [chemical binding]; other site 441620002072 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 441620002073 Malic enzyme, N-terminal domain; Region: malic; pfam00390 441620002074 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 441620002075 putative NAD(P) binding site [chemical binding]; other site 441620002076 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 441620002077 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 441620002078 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 441620002079 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 441620002080 Probable Catalytic site; other site 441620002081 metal-binding site 441620002082 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 441620002083 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620002084 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 441620002085 hypothetical protein; Validated; Region: PRK09104 441620002086 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 441620002087 metal binding site [ion binding]; metal-binding site 441620002088 putative dimer interface [polypeptide binding]; other site 441620002089 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 441620002090 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 441620002091 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441620002092 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 441620002093 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 441620002094 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 441620002095 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441620002096 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441620002097 camphor resistance protein CrcB; Provisional; Region: PRK14198 441620002098 Predicted membrane protein [Function unknown]; Region: COG2510 441620002099 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 441620002100 Helix-turn-helix domain; Region: HTH_37; pfam13744 441620002101 non-specific DNA binding site [nucleotide binding]; other site 441620002102 salt bridge; other site 441620002103 sequence-specific DNA binding site [nucleotide binding]; other site 441620002104 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 441620002105 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441620002106 MarR family; Region: MarR_2; pfam12802 441620002107 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441620002108 active site 441620002109 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 441620002110 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 441620002111 Probable Catalytic site; other site 441620002112 metal-binding site 441620002113 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 441620002114 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 441620002115 substrate binding site; other site 441620002116 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 441620002117 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 441620002118 NAD binding site [chemical binding]; other site 441620002119 homotetramer interface [polypeptide binding]; other site 441620002120 homodimer interface [polypeptide binding]; other site 441620002121 substrate binding site [chemical binding]; other site 441620002122 active site 441620002123 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 441620002124 Methyltransferase domain; Region: Methyltransf_23; pfam13489 441620002125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620002126 S-adenosylmethionine binding site [chemical binding]; other site 441620002127 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 441620002128 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 441620002129 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441620002130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620002131 NAD(P) binding site [chemical binding]; other site 441620002132 active site 441620002133 Response regulator receiver domain; Region: Response_reg; pfam00072 441620002134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620002135 active site 441620002136 phosphorylation site [posttranslational modification] 441620002137 intermolecular recognition site; other site 441620002138 dimerization interface [polypeptide binding]; other site 441620002139 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 441620002140 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 441620002141 inhibitor-cofactor binding pocket; inhibition site 441620002142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620002143 catalytic residue [active] 441620002144 glycine dehydrogenase; Provisional; Region: PRK05367 441620002145 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 441620002146 tetramer interface [polypeptide binding]; other site 441620002147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620002148 catalytic residue [active] 441620002149 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 441620002150 tetramer interface [polypeptide binding]; other site 441620002151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620002152 catalytic residue [active] 441620002153 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 441620002154 lipoyl attachment site [posttranslational modification]; other site 441620002155 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 441620002156 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 441620002157 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 441620002158 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 441620002159 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441620002160 catalytic residue [active] 441620002161 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 441620002162 NlpC/P60 family; Region: NLPC_P60; pfam00877 441620002163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620002164 C factor cell-cell signaling protein; Provisional; Region: PRK09009 441620002165 NAD(P) binding site [chemical binding]; other site 441620002166 active site 441620002167 PemK-like protein; Region: PemK; pfam02452 441620002168 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 441620002169 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 441620002170 MgtC family; Region: MgtC; pfam02308 441620002171 MoxR-like ATPases [General function prediction only]; Region: COG0714 441620002172 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 441620002173 ATP binding site [chemical binding]; other site 441620002174 Walker A motif; other site 441620002175 Walker B motif; other site 441620002176 arginine finger; other site 441620002177 Protein of unknown function DUF58; Region: DUF58; pfam01882 441620002178 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 441620002179 metal ion-dependent adhesion site (MIDAS); other site 441620002180 von Willebrand factor type A domain; Region: VWA_2; pfam13519 441620002181 metal ion-dependent adhesion site (MIDAS); other site 441620002182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441620002183 Tetratricopeptide repeat; Region: TPR_16; pfam13432 441620002184 TPR motif; other site 441620002185 binding surface 441620002186 Oxygen tolerance; Region: BatD; pfam13584 441620002187 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 441620002188 putative heme binding pocket [chemical binding]; other site 441620002189 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 441620002190 EamA-like transporter family; Region: EamA; pfam00892 441620002191 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 441620002192 putative metal binding residues [ion binding]; other site 441620002193 methionine sulfoxide reductase B; Provisional; Region: PRK00222 441620002194 SelR domain; Region: SelR; pfam01641 441620002195 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 441620002196 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620002197 PAS domain; Region: PAS_9; pfam13426 441620002198 putative active site [active] 441620002199 heme pocket [chemical binding]; other site 441620002200 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620002201 PAS fold; Region: PAS_3; pfam08447 441620002202 putative active site [active] 441620002203 heme pocket [chemical binding]; other site 441620002204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620002205 HWE histidine kinase; Region: HWE_HK; pfam07536 441620002206 malonyl-CoA synthase; Validated; Region: PRK07514 441620002207 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 441620002208 acyl-activating enzyme (AAE) consensus motif; other site 441620002209 active site 441620002210 AMP binding site [chemical binding]; other site 441620002211 CoA binding site [chemical binding]; other site 441620002212 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 441620002213 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 441620002214 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 441620002215 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 441620002216 intracellular protease, PfpI family; Region: PfpI; TIGR01382 441620002217 proposed catalytic triad [active] 441620002218 conserved cys residue [active] 441620002219 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 441620002220 DNA-binding site [nucleotide binding]; DNA binding site 441620002221 RNA-binding motif; other site 441620002222 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 441620002223 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 441620002224 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 441620002225 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 441620002226 Permease; Region: Permease; pfam02405 441620002227 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 441620002228 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 441620002229 Walker A/P-loop; other site 441620002230 ATP binding site [chemical binding]; other site 441620002231 Q-loop/lid; other site 441620002232 ABC transporter signature motif; other site 441620002233 Walker B; other site 441620002234 D-loop; other site 441620002235 H-loop/switch region; other site 441620002236 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 441620002237 mce related protein; Region: MCE; pfam02470 441620002238 Protein of unknown function (DUF330); Region: DUF330; cl01135 441620002239 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 441620002240 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 441620002241 active site 441620002242 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 441620002243 UbiA prenyltransferase family; Region: UbiA; pfam01040 441620002244 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 441620002245 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 441620002246 active site 441620002247 homotetramer interface [polypeptide binding]; other site 441620002248 homodimer interface [polypeptide binding]; other site 441620002249 glutamate--cysteine ligase; Region: PLN02611 441620002250 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 441620002251 CPxP motif; other site 441620002252 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 441620002253 dimer interface [polypeptide binding]; other site 441620002254 ADP-ribose binding site [chemical binding]; other site 441620002255 active site 441620002256 nudix motif; other site 441620002257 metal binding site [ion binding]; metal-binding site 441620002258 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 441620002259 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 441620002260 primary metal binding site; other site 441620002261 catalytic residues [active] 441620002262 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 441620002263 Predicted aspartyl protease [General function prediction only]; Region: COG3577 441620002264 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 441620002265 catalytic motif [active] 441620002266 Catalytic residue [active] 441620002267 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 441620002268 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 441620002269 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 441620002270 cobalamin synthase; Reviewed; Region: cobS; PRK00235 441620002271 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 441620002272 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 441620002273 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 441620002274 putative dimer interface [polypeptide binding]; other site 441620002275 active site pocket [active] 441620002276 putative cataytic base [active] 441620002277 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620002278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620002279 dimer interface [polypeptide binding]; other site 441620002280 phosphorylation site [posttranslational modification] 441620002281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620002282 ATP binding site [chemical binding]; other site 441620002283 Mg2+ binding site [ion binding]; other site 441620002284 G-X-G motif; other site 441620002285 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 441620002286 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441620002287 catalytic loop [active] 441620002288 iron binding site [ion binding]; other site 441620002289 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441620002290 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 441620002291 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441620002292 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441620002293 PAS fold; Region: PAS_4; pfam08448 441620002294 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620002295 GAF domain; Region: GAF; pfam01590 441620002296 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620002297 GAF domain; Region: GAF; cl17456 441620002298 PAS domain; Region: PAS_9; pfam13426 441620002299 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620002300 putative active site [active] 441620002301 heme pocket [chemical binding]; other site 441620002302 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620002303 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 441620002304 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620002305 PAS fold; Region: PAS_3; pfam08447 441620002306 putative active site [active] 441620002307 heme pocket [chemical binding]; other site 441620002308 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620002309 HWE histidine kinase; Region: HWE_HK; smart00911 441620002310 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 441620002311 Amidase; Region: Amidase; cl11426 441620002312 Amidase; Region: Amidase; cl11426 441620002313 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 441620002314 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 441620002315 B1 nucleotide binding pocket [chemical binding]; other site 441620002316 B2 nucleotide binding pocket [chemical binding]; other site 441620002317 CAS motifs; other site 441620002318 active site 441620002319 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 441620002320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441620002321 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 441620002322 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 441620002323 FAD binding domain; Region: FAD_binding_4; pfam01565 441620002324 Cytochrome c; Region: Cytochrom_C; cl11414 441620002325 Transcriptional regulators [Transcription]; Region: MarR; COG1846 441620002326 MarR family; Region: MarR; pfam01047 441620002327 Predicted integral membrane protein [Function unknown]; Region: COG5436 441620002328 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 441620002329 Transglycosylase; Region: Transgly; pfam00912 441620002330 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 441620002331 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 441620002332 hypothetical protein; Provisional; Region: PRK05170 441620002333 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 441620002334 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 441620002335 TadE-like protein; Region: TadE; pfam07811 441620002336 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 441620002337 TadE-like protein; Region: TadE; pfam07811 441620002338 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 441620002339 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 441620002340 Predicted ATPase [General function prediction only]; Region: COG1485 441620002341 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 441620002342 active site 441620002343 DNA binding site [nucleotide binding] 441620002344 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 441620002345 RNA/DNA hybrid binding site [nucleotide binding]; other site 441620002346 active site 441620002347 glutathione synthetase; Provisional; Region: PRK05246 441620002348 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 441620002349 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 441620002350 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 441620002351 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 441620002352 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 441620002353 amidase catalytic site [active] 441620002354 Zn binding residues [ion binding]; other site 441620002355 substrate binding site [chemical binding]; other site 441620002356 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441620002357 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 441620002358 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 441620002359 putative metal binding site [ion binding]; other site 441620002360 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 441620002361 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 441620002362 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 441620002363 dimer interface [polypeptide binding]; other site 441620002364 catalytic residues [active] 441620002365 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 441620002366 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 441620002367 FMN binding site [chemical binding]; other site 441620002368 active site 441620002369 catalytic residues [active] 441620002370 substrate binding site [chemical binding]; other site 441620002371 PAS fold; Region: PAS_7; pfam12860 441620002372 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620002373 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620002374 metal binding site [ion binding]; metal-binding site 441620002375 active site 441620002376 I-site; other site 441620002377 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 441620002378 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 441620002379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620002380 active site 441620002381 phosphorylation site [posttranslational modification] 441620002382 intermolecular recognition site; other site 441620002383 dimerization interface [polypeptide binding]; other site 441620002384 Sensors of blue-light using FAD; Region: BLUF; pfam04940 441620002385 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 441620002386 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 441620002387 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 441620002388 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441620002389 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 441620002390 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441620002391 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 441620002392 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 441620002393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441620002394 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 441620002395 peptide chain release factor 1; Validated; Region: prfA; PRK00591 441620002396 This domain is found in peptide chain release factors; Region: PCRF; smart00937 441620002397 RF-1 domain; Region: RF-1; pfam00472 441620002398 GAF domain; Region: GAF; pfam01590 441620002399 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 441620002400 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 441620002401 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 441620002402 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 441620002403 aspartate kinase; Reviewed; Region: PRK06635 441620002404 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 441620002405 putative nucleotide binding site [chemical binding]; other site 441620002406 putative catalytic residues [active] 441620002407 putative Mg ion binding site [ion binding]; other site 441620002408 putative aspartate binding site [chemical binding]; other site 441620002409 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 441620002410 putative allosteric regulatory site; other site 441620002411 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 441620002412 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 441620002413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620002414 S-adenosylmethionine binding site [chemical binding]; other site 441620002415 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 441620002416 substrate binding site [chemical binding]; other site 441620002417 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 441620002418 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 441620002419 NAD(P) binding site [chemical binding]; other site 441620002420 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 441620002421 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 441620002422 Cytochrome c; Region: Cytochrom_C; pfam00034 441620002423 HAMP domain; Region: HAMP; pfam00672 441620002424 dimerization interface [polypeptide binding]; other site 441620002425 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620002426 dimer interface [polypeptide binding]; other site 441620002427 putative CheW interface [polypeptide binding]; other site 441620002428 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 441620002429 active site 441620002430 putative DNA-binding cleft [nucleotide binding]; other site 441620002431 dimer interface [polypeptide binding]; other site 441620002432 Uncharacterized conserved protein [Function unknown]; Region: COG2353 441620002433 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 441620002434 RuvA N terminal domain; Region: RuvA_N; pfam01330 441620002435 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 441620002436 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620002437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620002438 active site 441620002439 phosphorylation site [posttranslational modification] 441620002440 intermolecular recognition site; other site 441620002441 dimerization interface [polypeptide binding]; other site 441620002442 response regulator PleD; Reviewed; Region: pleD; PRK09581 441620002443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620002444 active site 441620002445 phosphorylation site [posttranslational modification] 441620002446 intermolecular recognition site; other site 441620002447 dimerization interface [polypeptide binding]; other site 441620002448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620002449 active site 441620002450 phosphorylation site [posttranslational modification] 441620002451 intermolecular recognition site; other site 441620002452 dimerization interface [polypeptide binding]; other site 441620002453 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620002454 metal binding site [ion binding]; metal-binding site 441620002455 active site 441620002456 I-site; other site 441620002457 Predicted transcriptional regulator [Transcription]; Region: COG1959 441620002458 Transcriptional regulator; Region: Rrf2; cl17282 441620002459 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 441620002460 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 441620002461 heme-binding site [chemical binding]; other site 441620002462 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 441620002463 FAD binding pocket [chemical binding]; other site 441620002464 FAD binding motif [chemical binding]; other site 441620002465 phosphate binding motif [ion binding]; other site 441620002466 beta-alpha-beta structure motif; other site 441620002467 NAD binding pocket [chemical binding]; other site 441620002468 Heme binding pocket [chemical binding]; other site 441620002469 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 441620002470 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 441620002471 dimer interface [polypeptide binding]; other site 441620002472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620002473 catalytic residue [active] 441620002474 META domain; Region: META; cl01245 441620002475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 441620002476 non-specific DNA binding site [nucleotide binding]; other site 441620002477 salt bridge; other site 441620002478 sequence-specific DNA binding site [nucleotide binding]; other site 441620002479 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 441620002480 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441620002481 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441620002482 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620002483 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620002484 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 441620002485 putative dimerization interface [polypeptide binding]; other site 441620002486 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 441620002487 metal binding site [ion binding]; metal-binding site 441620002488 active site 441620002489 phosphoribulokinase; Provisional; Region: PRK15453 441620002490 active site 441620002491 Thioesterase domain; Region: Thioesterase; pfam00975 441620002492 hypothetical protein; Validated; Region: PRK00110 441620002493 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441620002494 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 441620002495 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 441620002496 Protein of unknown function (DUF497); Region: DUF497; pfam04365 441620002497 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620002498 non-specific DNA binding site [nucleotide binding]; other site 441620002499 salt bridge; other site 441620002500 sequence-specific DNA binding site [nucleotide binding]; other site 441620002501 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 441620002502 oxyanion hole [active] 441620002503 OpgC protein; Region: OpgC_C; pfam10129 441620002504 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 441620002505 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441620002506 motif II; other site 441620002507 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 441620002508 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 441620002509 substrate binding site [chemical binding]; other site 441620002510 hexamer interface [polypeptide binding]; other site 441620002511 metal binding site [ion binding]; metal-binding site 441620002512 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 441620002513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441620002514 Coenzyme A binding pocket [chemical binding]; other site 441620002515 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 441620002516 ornithine decarboxylase; Provisional; Region: PRK13578 441620002517 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 441620002518 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441620002519 catalytic residue [active] 441620002520 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 441620002521 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 441620002522 MPT binding site; other site 441620002523 trimer interface [polypeptide binding]; other site 441620002524 adenylosuccinate lyase; Provisional; Region: PRK07492 441620002525 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 441620002526 tetramer interface [polypeptide binding]; other site 441620002527 active site 441620002528 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 441620002529 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 441620002530 homodimer interface [polypeptide binding]; other site 441620002531 substrate-cofactor binding pocket; other site 441620002532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620002533 catalytic residue [active] 441620002534 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 441620002535 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 441620002536 GDP-binding site [chemical binding]; other site 441620002537 ACT binding site; other site 441620002538 IMP binding site; other site 441620002539 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 441620002540 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 441620002541 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441620002542 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441620002543 DNA binding residues [nucleotide binding] 441620002544 Transposase, Mutator family; Region: Transposase_mut; pfam00872 441620002545 MULE transposase domain; Region: MULE; pfam10551 441620002546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441620002547 Coenzyme A binding pocket [chemical binding]; other site 441620002548 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 441620002549 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441620002550 RNA binding surface [nucleotide binding]; other site 441620002551 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 441620002552 active site 441620002553 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 441620002554 active site 441620002555 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441620002556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620002557 active site 441620002558 phosphorylation site [posttranslational modification] 441620002559 intermolecular recognition site; other site 441620002560 dimerization interface [polypeptide binding]; other site 441620002561 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620002562 DNA binding site [nucleotide binding] 441620002563 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 441620002564 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 441620002565 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 441620002566 Ligand Binding Site [chemical binding]; other site 441620002567 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620002568 dimer interface [polypeptide binding]; other site 441620002569 phosphorylation site [posttranslational modification] 441620002570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620002571 ATP binding site [chemical binding]; other site 441620002572 Mg2+ binding site [ion binding]; other site 441620002573 G-X-G motif; other site 441620002574 potassium-transporting ATPase subunit C; Provisional; Region: PRK13999 441620002575 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 441620002576 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441620002577 Soluble P-type ATPase [General function prediction only]; Region: COG4087 441620002578 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 441620002579 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 441620002580 Peptidase family M23; Region: Peptidase_M23; pfam01551 441620002581 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 441620002582 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 441620002583 active site 441620002584 HIGH motif; other site 441620002585 nucleotide binding site [chemical binding]; other site 441620002586 active site 441620002587 KMSKS motif; other site 441620002588 heat shock protein 90; Provisional; Region: PRK05218 441620002589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620002590 ATP binding site [chemical binding]; other site 441620002591 Mg2+ binding site [ion binding]; other site 441620002592 G-X-G motif; other site 441620002593 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 441620002594 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 441620002595 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 441620002596 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 441620002597 DAK2 domain; Region: Dak2; pfam02734 441620002598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620002599 S-adenosylmethionine binding site [chemical binding]; other site 441620002600 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 441620002601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620002602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620002603 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 441620002604 active site 441620002605 putative homodimer interface [polypeptide binding]; other site 441620002606 SAM binding site [chemical binding]; other site 441620002607 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 441620002608 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 441620002609 S-adenosylmethionine binding site [chemical binding]; other site 441620002610 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620002611 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620002612 metal binding site [ion binding]; metal-binding site 441620002613 active site 441620002614 I-site; other site 441620002615 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 441620002616 active site 441620002617 SAM binding site [chemical binding]; other site 441620002618 homodimer interface [polypeptide binding]; other site 441620002619 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 441620002620 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 441620002621 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441620002622 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620002623 non-specific DNA binding site [nucleotide binding]; other site 441620002624 salt bridge; other site 441620002625 sequence-specific DNA binding site [nucleotide binding]; other site 441620002626 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 441620002627 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441620002628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620002629 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 441620002630 Bacterial sugar transferase; Region: Bac_transf; pfam02397 441620002631 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 441620002632 metal binding site 2 [ion binding]; metal-binding site 441620002633 putative DNA binding helix; other site 441620002634 metal binding site 1 [ion binding]; metal-binding site 441620002635 dimer interface [polypeptide binding]; other site 441620002636 structural Zn2+ binding site [ion binding]; other site 441620002637 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 441620002638 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 441620002639 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 441620002640 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 441620002641 ABC-ATPase subunit interface; other site 441620002642 dimer interface [polypeptide binding]; other site 441620002643 putative PBP binding regions; other site 441620002644 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 441620002645 classical (c) SDRs; Region: SDR_c; cd05233 441620002646 NAD(P) binding site [chemical binding]; other site 441620002647 active site 441620002648 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 441620002649 active site 441620002650 cosubstrate binding site; other site 441620002651 substrate binding site [chemical binding]; other site 441620002652 catalytic site [active] 441620002653 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 441620002654 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 441620002655 Ligand binding site; other site 441620002656 metal-binding site 441620002657 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 441620002658 putative MPT binding site; other site 441620002659 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 441620002660 XdhC Rossmann domain; Region: XdhC_C; pfam13478 441620002661 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 441620002662 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 441620002663 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 441620002664 dimerization interface [polypeptide binding]; other site 441620002665 ligand binding site [chemical binding]; other site 441620002666 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 441620002667 rRNA binding site [nucleotide binding]; other site 441620002668 predicted 30S ribosome binding site; other site 441620002669 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 441620002670 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 441620002671 CAP-like domain; other site 441620002672 active site 441620002673 primary dimer interface [polypeptide binding]; other site 441620002674 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 441620002675 Recombination protein O N terminal; Region: RecO_N; pfam11967 441620002676 Recombination protein O C terminal; Region: RecO_C; pfam02565 441620002677 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 441620002678 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 441620002679 putative active site pocket [active] 441620002680 dimerization interface [polypeptide binding]; other site 441620002681 putative catalytic residue [active] 441620002682 lytic murein transglycosylase; Region: MltB_2; TIGR02283 441620002683 murein hydrolase B; Provisional; Region: PRK10760; cl17906 441620002684 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 441620002685 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 441620002686 putative active site [active] 441620002687 putative PHP Thumb interface [polypeptide binding]; other site 441620002688 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 441620002689 generic binding surface II; other site 441620002690 generic binding surface I; other site 441620002691 Helix-turn-helix domain; Region: HTH_37; pfam13744 441620002692 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441620002693 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441620002694 Walker A/P-loop; other site 441620002695 ATP binding site [chemical binding]; other site 441620002696 Q-loop/lid; other site 441620002697 ABC transporter signature motif; other site 441620002698 Walker B; other site 441620002699 D-loop; other site 441620002700 H-loop/switch region; other site 441620002701 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 441620002702 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441620002703 FtsX-like permease family; Region: FtsX; pfam02687 441620002704 prolyl-tRNA synthetase; Provisional; Region: PRK12325 441620002705 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 441620002706 dimer interface [polypeptide binding]; other site 441620002707 motif 1; other site 441620002708 active site 441620002709 motif 2; other site 441620002710 motif 3; other site 441620002711 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 441620002712 anticodon binding site; other site 441620002713 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 441620002714 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 441620002715 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 441620002716 dimer interface [polypeptide binding]; other site 441620002717 substrate binding site [chemical binding]; other site 441620002718 metal binding site [ion binding]; metal-binding site 441620002719 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 441620002720 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441620002721 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 441620002722 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 441620002723 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 441620002724 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 441620002725 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 441620002726 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 441620002727 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 441620002728 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 441620002729 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 441620002730 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 441620002731 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 441620002732 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 441620002733 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 441620002734 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 441620002735 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 441620002736 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 441620002737 4Fe-4S binding domain; Region: Fer4; pfam00037 441620002738 4Fe-4S binding domain; Region: Fer4; pfam00037 441620002739 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 441620002740 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 441620002741 NADH dehydrogenase subunit G; Validated; Region: PRK09130 441620002742 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441620002743 catalytic loop [active] 441620002744 iron binding site [ion binding]; other site 441620002745 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 441620002746 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 441620002747 molybdopterin cofactor binding site; other site 441620002748 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 441620002749 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 441620002750 SLBB domain; Region: SLBB; pfam10531 441620002751 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 441620002752 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 441620002753 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 441620002754 putative dimer interface [polypeptide binding]; other site 441620002755 [2Fe-2S] cluster binding site [ion binding]; other site 441620002756 Uncharacterized conserved protein [Function unknown]; Region: COG3743 441620002757 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 441620002758 NADH dehydrogenase subunit D; Validated; Region: PRK06075 441620002759 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 441620002760 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 441620002761 NADH dehydrogenase subunit B; Validated; Region: PRK06411 441620002762 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 441620002763 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 441620002764 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 441620002765 pseudoazurin; Region: pseudoazurin; TIGR02375 441620002766 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 441620002767 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 441620002768 ATP-grasp domain; Region: ATP-grasp_4; cl17255 441620002769 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 441620002770 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 441620002771 ATP-grasp domain; Region: ATP-grasp_4; cl17255 441620002772 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 441620002773 IMP binding site; other site 441620002774 dimer interface [polypeptide binding]; other site 441620002775 partial ornithine binding site; other site 441620002776 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 441620002777 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 441620002778 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 441620002779 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 441620002780 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 441620002781 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 441620002782 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441620002783 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441620002784 Dicarboxylate transport; Region: DctA-YdbH; cl14674 441620002785 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620002786 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620002787 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 441620002788 putative effector binding pocket; other site 441620002789 dimerization interface [polypeptide binding]; other site 441620002790 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 441620002791 Dehydroquinase class II; Region: DHquinase_II; pfam01220 441620002792 trimer interface [polypeptide binding]; other site 441620002793 active site 441620002794 dimer interface [polypeptide binding]; other site 441620002795 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 441620002796 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 441620002797 carboxyltransferase (CT) interaction site; other site 441620002798 biotinylation site [posttranslational modification]; other site 441620002799 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 441620002800 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 441620002801 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 441620002802 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 441620002803 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 441620002804 WHG domain; Region: WHG; pfam13305 441620002805 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 441620002806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 441620002807 Major royal jelly protein; Region: MRJP; pfam03022 441620002808 NADH dehydrogenase; Validated; Region: PRK08183 441620002809 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 441620002810 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 441620002811 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 441620002812 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 441620002813 active site 441620002814 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 441620002815 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 441620002816 TSCPD domain; Region: TSCPD; pfam12637 441620002817 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620002818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620002819 ATP binding site [chemical binding]; other site 441620002820 Mg2+ binding site [ion binding]; other site 441620002821 G-X-G motif; other site 441620002822 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441620002823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620002824 active site 441620002825 phosphorylation site [posttranslational modification] 441620002826 intermolecular recognition site; other site 441620002827 dimerization interface [polypeptide binding]; other site 441620002828 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620002829 DNA binding site [nucleotide binding] 441620002830 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441620002831 MarR family; Region: MarR; pfam01047 441620002832 MarR family; Region: MarR_2; cl17246 441620002833 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 441620002834 metabolite-proton symporter; Region: 2A0106; TIGR00883 441620002835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620002836 putative substrate translocation pore; other site 441620002837 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 441620002838 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 441620002839 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 441620002840 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 441620002841 maleylacetoacetate isomerase; Region: maiA; TIGR01262 441620002842 C-terminal domain interface [polypeptide binding]; other site 441620002843 GSH binding site (G-site) [chemical binding]; other site 441620002844 putative dimer interface [polypeptide binding]; other site 441620002845 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 441620002846 dimer interface [polypeptide binding]; other site 441620002847 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 441620002848 N-terminal domain interface [polypeptide binding]; other site 441620002849 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 441620002850 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 441620002851 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441620002852 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620002853 dimer interface [polypeptide binding]; other site 441620002854 putative CheW interface [polypeptide binding]; other site 441620002855 PRC-barrel domain; Region: PRC; pfam05239 441620002856 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 441620002857 CsbD-like; Region: CsbD; cl17424 441620002858 CsbD-like; Region: CsbD; pfam05532 441620002859 CsbD-like; Region: CsbD; pfam05532 441620002860 CsbD-like; Region: CsbD; cl17424 441620002861 PAS domain; Region: PAS_9; pfam13426 441620002862 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 441620002863 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 441620002864 putative active site [active] 441620002865 heme pocket [chemical binding]; other site 441620002866 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441620002867 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441620002868 DNA binding residues [nucleotide binding] 441620002869 dimerization interface [polypeptide binding]; other site 441620002870 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 441620002871 active site 441620002872 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 441620002873 Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346 441620002874 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 441620002875 Strictosidine synthase; Region: Str_synth; pfam03088 441620002876 Cupin domain; Region: Cupin_2; cl17218 441620002877 Predicted membrane protein [Function unknown]; Region: COG2259 441620002878 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 441620002879 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 441620002880 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 441620002881 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 441620002882 Cu(I) binding site [ion binding]; other site 441620002883 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 441620002884 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441620002885 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 441620002886 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 441620002887 active site 441620002888 catalytic site [active] 441620002889 tetramer interface [polypeptide binding]; other site 441620002890 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 441620002891 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620002892 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620002893 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 441620002894 putative effector binding pocket; other site 441620002895 dimerization interface [polypeptide binding]; other site 441620002896 Predicted membrane protein [Function unknown]; Region: COG3748 441620002897 Protein of unknown function (DUF989); Region: DUF989; pfam06181 441620002898 Cytochrome c; Region: Cytochrom_C; pfam00034 441620002899 hypothetical protein; Provisional; Region: PRK11171 441620002900 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 441620002901 Cupin domain; Region: Cupin_2; pfam07883 441620002902 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 441620002903 ureidoglycolate hydrolase; Provisional; Region: PRK03606 441620002904 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 441620002905 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441620002906 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 441620002907 pyrimidine utilization protein A; Region: RutA; TIGR03612 441620002908 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 441620002909 active site 441620002910 dimer interface [polypeptide binding]; other site 441620002911 non-prolyl cis peptide bond; other site 441620002912 insertion regions; other site 441620002913 Isochorismatase family; Region: Isochorismatase; pfam00857 441620002914 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 441620002915 catalytic triad [active] 441620002916 conserved cis-peptide bond; other site 441620002917 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 441620002918 homotrimer interaction site [polypeptide binding]; other site 441620002919 putative active site [active] 441620002920 pyrimidine utilization protein D; Region: RutD; TIGR03611 441620002921 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 441620002922 Flavin Reductases; Region: FlaRed; cl00801 441620002923 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 441620002924 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441620002925 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441620002926 Walker A/P-loop; other site 441620002927 ATP binding site [chemical binding]; other site 441620002928 Q-loop/lid; other site 441620002929 ABC transporter signature motif; other site 441620002930 Walker B; other site 441620002931 D-loop; other site 441620002932 H-loop/switch region; other site 441620002933 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 441620002934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 441620002935 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 441620002936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620002937 dimer interface [polypeptide binding]; other site 441620002938 conserved gate region; other site 441620002939 putative PBP binding loops; other site 441620002940 ABC-ATPase subunit interface; other site 441620002941 NMT1/THI5 like; Region: NMT1; pfam09084 441620002942 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 441620002943 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 441620002944 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441620002945 catalytic loop [active] 441620002946 iron binding site [ion binding]; other site 441620002947 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441620002948 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 441620002949 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441620002950 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441620002951 guanine deaminase; Provisional; Region: PRK09228 441620002952 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 441620002953 active site 441620002954 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620002955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620002956 LysR substrate binding domain; Region: LysR_substrate; pfam03466 441620002957 dimerization interface [polypeptide binding]; other site 441620002958 cytosine deaminase-like protein; Validated; Region: PRK07583 441620002959 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 441620002960 active site 441620002961 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620002962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620002963 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 441620002964 dimerization interface [polypeptide binding]; other site 441620002965 NMT1/THI5 like; Region: NMT1; pfam09084 441620002966 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 441620002967 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441620002968 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441620002969 Walker A/P-loop; other site 441620002970 ATP binding site [chemical binding]; other site 441620002971 Q-loop/lid; other site 441620002972 ABC transporter signature motif; other site 441620002973 Walker B; other site 441620002974 D-loop; other site 441620002975 H-loop/switch region; other site 441620002976 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 441620002977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620002978 dimer interface [polypeptide binding]; other site 441620002979 conserved gate region; other site 441620002980 putative PBP binding loops; other site 441620002981 ABC-ATPase subunit interface; other site 441620002982 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 441620002983 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 441620002984 iron-sulfur cluster [ion binding]; other site 441620002985 [2Fe-2S] cluster binding site [ion binding]; other site 441620002986 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 441620002987 hydrophobic ligand binding site; other site 441620002988 NMT1/THI5 like; Region: NMT1; pfam09084 441620002989 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 441620002990 oxidase reductase; Provisional; Region: PTZ00273 441620002991 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 441620002992 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 441620002993 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 441620002994 FAD binding domain; Region: FAD_binding_4; pfam01565 441620002995 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 441620002996 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 441620002997 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 441620002998 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441620002999 acyl-activating enzyme (AAE) consensus motif; other site 441620003000 AMP binding site [chemical binding]; other site 441620003001 active site 441620003002 CoA binding site [chemical binding]; other site 441620003003 Creatinine amidohydrolase; Region: Creatininase; pfam02633 441620003004 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 441620003005 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 441620003006 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 441620003007 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 441620003008 putative ligand binding site [chemical binding]; other site 441620003009 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 441620003010 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 441620003011 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 441620003012 Walker A/P-loop; other site 441620003013 ATP binding site [chemical binding]; other site 441620003014 Q-loop/lid; other site 441620003015 ABC transporter signature motif; other site 441620003016 Walker B; other site 441620003017 D-loop; other site 441620003018 H-loop/switch region; other site 441620003019 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 441620003020 Isochorismatase family; Region: Isochorismatase; pfam00857 441620003021 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 441620003022 catalytic triad [active] 441620003023 conserved cis-peptide bond; other site 441620003024 Protein of unknown function (DUF497); Region: DUF497; cl01108 441620003025 formamidase; Provisional; Region: amiF; PRK13287 441620003026 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 441620003027 multimer interface [polypeptide binding]; other site 441620003028 active site 441620003029 catalytic triad [active] 441620003030 dimer interface [polypeptide binding]; other site 441620003031 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 441620003032 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 441620003033 TM-ABC transporter signature motif; other site 441620003034 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 441620003035 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 441620003036 TM-ABC transporter signature motif; other site 441620003037 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 441620003038 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 441620003039 putative ligand binding site [chemical binding]; other site 441620003040 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 441620003041 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 441620003042 TM-ABC transporter signature motif; other site 441620003043 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 441620003044 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 441620003045 TM-ABC transporter signature motif; other site 441620003046 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 441620003047 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 441620003048 Walker A/P-loop; other site 441620003049 ATP binding site [chemical binding]; other site 441620003050 Q-loop/lid; other site 441620003051 ABC transporter signature motif; other site 441620003052 Walker B; other site 441620003053 D-loop; other site 441620003054 H-loop/switch region; other site 441620003055 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 441620003056 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 441620003057 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 441620003058 active site 441620003059 putative substrate binding pocket [chemical binding]; other site 441620003060 Isochorismatase family; Region: Isochorismatase; pfam00857 441620003061 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 441620003062 catalytic triad [active] 441620003063 conserved cis-peptide bond; other site 441620003064 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 441620003065 amidase; Provisional; Region: PRK09201 441620003066 Amidase; Region: Amidase; cl11426 441620003067 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 441620003068 SnoaL-like domain; Region: SnoaL_3; pfam13474 441620003069 xanthine permease; Region: pbuX; TIGR03173 441620003070 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 441620003071 GAF domain; Region: GAF; pfam01590 441620003072 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620003073 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620003074 PAS domain; Region: PAS_9; pfam13426 441620003075 putative active site [active] 441620003076 heme pocket [chemical binding]; other site 441620003077 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620003078 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 441620003079 putative active site [active] 441620003080 heme pocket [chemical binding]; other site 441620003081 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620003082 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 441620003083 putative active site [active] 441620003084 heme pocket [chemical binding]; other site 441620003085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620003086 PAS fold; Region: PAS_3; pfam08447 441620003087 putative active site [active] 441620003088 heme pocket [chemical binding]; other site 441620003089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620003090 HWE histidine kinase; Region: HWE_HK; pfam07536 441620003091 PAS fold; Region: PAS_4; pfam08448 441620003092 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 441620003093 putative active site [active] 441620003094 heme pocket [chemical binding]; other site 441620003095 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620003096 PAS fold; Region: PAS_3; pfam08447 441620003097 putative active site [active] 441620003098 heme pocket [chemical binding]; other site 441620003099 PAS fold; Region: PAS_4; pfam08448 441620003100 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620003101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620003102 dimer interface [polypeptide binding]; other site 441620003103 phosphorylation site [posttranslational modification] 441620003104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620003105 ATP binding site [chemical binding]; other site 441620003106 Mg2+ binding site [ion binding]; other site 441620003107 G-X-G motif; other site 441620003108 Response regulator receiver domain; Region: Response_reg; pfam00072 441620003109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620003110 active site 441620003111 phosphorylation site [posttranslational modification] 441620003112 intermolecular recognition site; other site 441620003113 dimerization interface [polypeptide binding]; other site 441620003114 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 441620003115 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 441620003116 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 441620003117 dimer interface [polypeptide binding]; other site 441620003118 catalytic residues [active] 441620003119 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 441620003120 UreF; Region: UreF; pfam01730 441620003121 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 441620003122 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 441620003123 alpha-gamma subunit interface [polypeptide binding]; other site 441620003124 beta-gamma subunit interface [polypeptide binding]; other site 441620003125 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 441620003126 alpha-beta subunit interface [polypeptide binding]; other site 441620003127 urease subunit alpha; Reviewed; Region: ureC; PRK13308 441620003128 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 441620003129 subunit interactions [polypeptide binding]; other site 441620003130 active site 441620003131 flap region; other site 441620003132 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441620003133 UreD urease accessory protein; Region: UreD; pfam01774 441620003134 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 441620003135 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 441620003136 putative ligand binding site [chemical binding]; other site 441620003137 Predicted membrane protein [Function unknown]; Region: COG3503 441620003138 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 441620003139 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620003140 N-terminal plug; other site 441620003141 ligand-binding site [chemical binding]; other site 441620003142 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 441620003143 SnoaL-like domain; Region: SnoaL_3; pfam13474 441620003144 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 441620003145 OsmC-like protein; Region: OsmC; pfam02566 441620003146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620003147 PAS domain; Region: PAS_9; pfam13426 441620003148 putative active site [active] 441620003149 heme pocket [chemical binding]; other site 441620003150 formyl-coenzyme A transferase; Provisional; Region: PRK05398 441620003151 CoA-transferase family III; Region: CoA_transf_3; pfam02515 441620003152 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 441620003153 HPP family; Region: HPP; pfam04982 441620003154 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 441620003155 putative hydrolase; Provisional; Region: PRK11460 441620003156 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 441620003157 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 441620003158 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 441620003159 PYR/PP interface [polypeptide binding]; other site 441620003160 dimer interface [polypeptide binding]; other site 441620003161 TPP binding site [chemical binding]; other site 441620003162 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 441620003163 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 441620003164 TPP-binding site; other site 441620003165 dimer interface [polypeptide binding]; other site 441620003166 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 441620003167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620003168 putative substrate translocation pore; other site 441620003169 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 441620003170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620003171 putative substrate translocation pore; other site 441620003172 FOG: CBS domain [General function prediction only]; Region: COG0517 441620003173 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 441620003174 Zeta toxin; Region: Zeta_toxin; pfam06414 441620003175 formyl-coenzyme A transferase; Provisional; Region: PRK05398 441620003176 CoA-transferase family III; Region: CoA_transf_3; pfam02515 441620003177 Transcriptional regulators [Transcription]; Region: GntR; COG1802 441620003178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441620003179 DNA-binding site [nucleotide binding]; DNA binding site 441620003180 FCD domain; Region: FCD; pfam07729 441620003181 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 441620003182 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441620003183 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 441620003184 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 441620003185 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 441620003186 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 441620003187 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441620003188 FeS/SAM binding site; other site 441620003189 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 441620003190 active site 441620003191 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 441620003192 Ligand Binding Site [chemical binding]; other site 441620003193 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 441620003194 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441620003195 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 441620003196 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441620003197 active site 441620003198 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620003199 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 441620003200 putative ADP-binding pocket [chemical binding]; other site 441620003201 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 441620003202 regulatory protein interface [polypeptide binding]; other site 441620003203 active site 441620003204 regulatory phosphorylation site [posttranslational modification]; other site 441620003205 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 441620003206 active pocket/dimerization site; other site 441620003207 active site 441620003208 phosphorylation site [posttranslational modification] 441620003209 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 441620003210 active site 441620003211 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 441620003212 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620003213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441620003214 dimerization interface [polypeptide binding]; other site 441620003215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620003216 dimer interface [polypeptide binding]; other site 441620003217 phosphorylation site [posttranslational modification] 441620003218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620003219 ATP binding site [chemical binding]; other site 441620003220 Mg2+ binding site [ion binding]; other site 441620003221 G-X-G motif; other site 441620003222 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441620003223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620003224 active site 441620003225 phosphorylation site [posttranslational modification] 441620003226 intermolecular recognition site; other site 441620003227 dimerization interface [polypeptide binding]; other site 441620003228 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620003229 DNA binding site [nucleotide binding] 441620003230 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 441620003231 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 441620003232 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 441620003233 GTP-binding protein LepA; Provisional; Region: PRK05433 441620003234 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 441620003235 G1 box; other site 441620003236 putative GEF interaction site [polypeptide binding]; other site 441620003237 GTP/Mg2+ binding site [chemical binding]; other site 441620003238 Switch I region; other site 441620003239 G2 box; other site 441620003240 G3 box; other site 441620003241 Switch II region; other site 441620003242 G4 box; other site 441620003243 G5 box; other site 441620003244 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 441620003245 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 441620003246 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 441620003247 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441620003248 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620003249 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 441620003250 Protein of unknown function (DUF497); Region: DUF497; pfam04365 441620003251 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 441620003252 Transcriptional regulators [Transcription]; Region: PurR; COG1609 441620003253 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 441620003254 DNA binding site [nucleotide binding] 441620003255 domain linker motif; other site 441620003256 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280 441620003257 putative dimerization interface [polypeptide binding]; other site 441620003258 putative ligand binding site [chemical binding]; other site 441620003259 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 441620003260 active site 441620003261 phosphorylation site [posttranslational modification] 441620003262 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 441620003263 dimerization domain swap beta strand [polypeptide binding]; other site 441620003264 regulatory protein interface [polypeptide binding]; other site 441620003265 active site 441620003266 regulatory phosphorylation site [posttranslational modification]; other site 441620003267 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 441620003268 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 441620003269 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 441620003270 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 441620003271 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 441620003272 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 441620003273 putative substrate binding site [chemical binding]; other site 441620003274 putative ATP binding site [chemical binding]; other site 441620003275 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 441620003276 active site 441620003277 P-loop; other site 441620003278 phosphorylation site [posttranslational modification] 441620003279 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 441620003280 active site 441620003281 P-loop; other site 441620003282 phosphorylation site [posttranslational modification] 441620003283 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 441620003284 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 441620003285 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 441620003286 Transglycosylase; Region: Transgly; pfam00912 441620003287 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 441620003288 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 441620003289 flagellin; Reviewed; Region: PRK12688 441620003290 flagellin; Reviewed; Region: PRK12688 441620003291 Flagellar protein FlbT; Region: FlbT; pfam07378 441620003292 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 441620003293 Predicted membrane protein [Function unknown]; Region: COG4763 441620003294 Acyltransferase family; Region: Acyl_transf_3; pfam01757 441620003295 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 441620003296 Putative phosphatase (DUF442); Region: DUF442; cl17385 441620003297 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 441620003298 active site 441620003299 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 441620003300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620003301 putative substrate translocation pore; other site 441620003302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620003303 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 441620003304 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620003305 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620003306 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 441620003307 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 441620003308 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 441620003309 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 441620003310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620003311 active site 441620003312 phosphorylation site [posttranslational modification] 441620003313 intermolecular recognition site; other site 441620003314 dimerization interface [polypeptide binding]; other site 441620003315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620003316 Walker A motif; other site 441620003317 ATP binding site [chemical binding]; other site 441620003318 Walker B motif; other site 441620003319 arginine finger; other site 441620003320 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441620003321 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 441620003322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620003323 dimer interface [polypeptide binding]; other site 441620003324 phosphorylation site [posttranslational modification] 441620003325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620003326 ATP binding site [chemical binding]; other site 441620003327 Mg2+ binding site [ion binding]; other site 441620003328 G-X-G motif; other site 441620003329 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441620003330 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441620003331 Walker A/P-loop; other site 441620003332 ATP binding site [chemical binding]; other site 441620003333 Q-loop/lid; other site 441620003334 ABC transporter signature motif; other site 441620003335 Walker B; other site 441620003336 D-loop; other site 441620003337 H-loop/switch region; other site 441620003338 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 441620003339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620003340 dimer interface [polypeptide binding]; other site 441620003341 conserved gate region; other site 441620003342 putative PBP binding loops; other site 441620003343 ABC-ATPase subunit interface; other site 441620003344 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441620003345 NMT1/THI5 like; Region: NMT1; pfam09084 441620003346 substrate binding pocket [chemical binding]; other site 441620003347 membrane-bound complex binding site; other site 441620003348 septum formation inhibitor; Reviewed; Region: minC; PRK05177 441620003349 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 441620003350 Predicted membrane protein [Function unknown]; Region: COG4325 441620003351 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 441620003352 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 441620003353 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 441620003354 G1 box; other site 441620003355 putative GEF interaction site [polypeptide binding]; other site 441620003356 GTP/Mg2+ binding site [chemical binding]; other site 441620003357 Switch I region; other site 441620003358 G2 box; other site 441620003359 G3 box; other site 441620003360 Switch II region; other site 441620003361 G4 box; other site 441620003362 G5 box; other site 441620003363 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 441620003364 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 441620003365 CHASE3 domain; Region: CHASE3; pfam05227 441620003366 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 441620003367 dimerization interface [polypeptide binding]; other site 441620003368 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620003369 dimer interface [polypeptide binding]; other site 441620003370 putative CheW interface [polypeptide binding]; other site 441620003371 septum formation inhibitor; Reviewed; Region: minC; PRK05177 441620003372 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 441620003373 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 441620003374 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 441620003375 Switch I; other site 441620003376 Switch II; other site 441620003377 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 441620003378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620003379 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441620003380 putative substrate translocation pore; other site 441620003381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441620003382 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 441620003383 Cytochrome P450; Region: p450; cl12078 441620003384 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 441620003385 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 441620003386 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 441620003387 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 441620003388 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 441620003389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620003390 NAD(P) binding site [chemical binding]; other site 441620003391 active site 441620003392 short chain dehydrogenase; Provisional; Region: PRK05876 441620003393 classical (c) SDRs; Region: SDR_c; cd05233 441620003394 NAD(P) binding site [chemical binding]; other site 441620003395 active site 441620003396 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 441620003397 RibD C-terminal domain; Region: RibD_C; cl17279 441620003398 classical (c) SDRs; Region: SDR_c; cd05233 441620003399 NAD(P) binding site [chemical binding]; other site 441620003400 active site 441620003401 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441620003402 extended (e) SDRs; Region: SDR_e; cd08946 441620003403 NAD(P) binding site [chemical binding]; other site 441620003404 active site 441620003405 substrate binding site [chemical binding]; other site 441620003406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620003407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620003408 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 441620003409 putative effector binding pocket; other site 441620003410 putative dimerization interface [polypeptide binding]; other site 441620003411 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 441620003412 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 441620003413 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441620003414 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 441620003415 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 441620003416 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441620003417 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441620003418 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 441620003419 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 441620003420 hydrophobic ligand binding site; other site 441620003421 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 441620003422 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 441620003423 active site 441620003424 putative substrate binding pocket [chemical binding]; other site 441620003425 choline dehydrogenase; Validated; Region: PRK02106 441620003426 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 441620003427 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 441620003428 TPP-binding site [chemical binding]; other site 441620003429 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 441620003430 PYR/PP interface [polypeptide binding]; other site 441620003431 dimer interface [polypeptide binding]; other site 441620003432 TPP binding site [chemical binding]; other site 441620003433 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620003434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620003435 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 441620003436 dimerization interface [polypeptide binding]; other site 441620003437 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 441620003438 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441620003439 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 441620003440 dimer interface [polypeptide binding]; other site 441620003441 N-terminal domain interface [polypeptide binding]; other site 441620003442 substrate binding pocket (H-site) [chemical binding]; other site 441620003443 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 441620003444 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 441620003445 [2Fe-2S] cluster binding site [ion binding]; other site 441620003446 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 441620003447 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 441620003448 putative ligand binding site [chemical binding]; other site 441620003449 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 441620003450 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 441620003451 Walker A/P-loop; other site 441620003452 ATP binding site [chemical binding]; other site 441620003453 Q-loop/lid; other site 441620003454 ABC transporter signature motif; other site 441620003455 Walker B; other site 441620003456 D-loop; other site 441620003457 H-loop/switch region; other site 441620003458 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 441620003459 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 441620003460 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 441620003461 TM-ABC transporter signature motif; other site 441620003462 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 441620003463 TM-ABC transporter signature motif; other site 441620003464 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 441620003465 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 441620003466 active site 441620003467 putative substrate binding pocket [chemical binding]; other site 441620003468 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 441620003469 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 441620003470 hydrophobic ligand binding site; other site 441620003471 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 441620003472 Coenzyme A transferase; Region: CoA_trans; cl17247 441620003473 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620003474 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620003475 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 441620003476 putative dimerization interface [polypeptide binding]; other site 441620003477 putative substrate binding pocket [chemical binding]; other site 441620003478 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 441620003479 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 441620003480 NAD(P) binding site [chemical binding]; other site 441620003481 catalytic residues [active] 441620003482 catalytic residues [active] 441620003483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620003484 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 441620003485 NAD(P) binding site [chemical binding]; other site 441620003486 active site 441620003487 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 441620003488 Fumarase C-terminus; Region: Fumerase_C; pfam05683 441620003489 benzoate transport; Region: 2A0115; TIGR00895 441620003490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620003491 putative substrate translocation pore; other site 441620003492 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 441620003493 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 441620003494 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620003495 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 441620003496 putative dimerization interface [polypeptide binding]; other site 441620003497 putative substrate binding pocket [chemical binding]; other site 441620003498 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 441620003499 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 441620003500 NAD(P) binding site [chemical binding]; other site 441620003501 catalytic residues [active] 441620003502 choline dehydrogenase; Validated; Region: PRK02106 441620003503 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 441620003504 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 441620003505 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 441620003506 Methyltransferase domain; Region: Methyltransf_23; pfam13489 441620003507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620003508 S-adenosylmethionine binding site [chemical binding]; other site 441620003509 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 441620003510 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 441620003511 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 441620003512 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 441620003513 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441620003514 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 441620003515 NAD binding site [chemical binding]; other site 441620003516 putative substrate binding site 2 [chemical binding]; other site 441620003517 putative substrate binding site 1 [chemical binding]; other site 441620003518 active site 441620003519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 441620003520 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 441620003521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 441620003522 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 441620003523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 441620003524 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 441620003525 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441620003526 B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295 441620003527 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 441620003528 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441620003529 FeS/SAM binding site; other site 441620003530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620003531 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441620003532 NAD(P) binding site [chemical binding]; other site 441620003533 active site 441620003534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620003535 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441620003536 NAD(P) binding site [chemical binding]; other site 441620003537 active site 441620003538 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 441620003539 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 441620003540 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 441620003541 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 441620003542 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 441620003543 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441620003544 enoyl-CoA hydratase; Provisional; Region: PRK05862 441620003545 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 441620003546 substrate binding site [chemical binding]; other site 441620003547 oxyanion hole (OAH) forming residues; other site 441620003548 trimer interface [polypeptide binding]; other site 441620003549 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 441620003550 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620003551 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441620003552 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 441620003553 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 441620003554 DXD motif; other site 441620003555 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 441620003556 Sel1-like repeats; Region: SEL1; smart00671 441620003557 Sel1-like repeats; Region: SEL1; smart00671 441620003558 Sel1-like repeats; Region: SEL1; smart00671 441620003559 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 441620003560 iron-sulfur cluster [ion binding]; other site 441620003561 [2Fe-2S] cluster binding site [ion binding]; other site 441620003562 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 441620003563 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 441620003564 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 441620003565 Walker A/P-loop; other site 441620003566 ATP binding site [chemical binding]; other site 441620003567 Q-loop/lid; other site 441620003568 ABC transporter signature motif; other site 441620003569 Walker B; other site 441620003570 D-loop; other site 441620003571 H-loop/switch region; other site 441620003572 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 441620003573 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 441620003574 Walker A/P-loop; other site 441620003575 ATP binding site [chemical binding]; other site 441620003576 Q-loop/lid; other site 441620003577 ABC transporter signature motif; other site 441620003578 Walker B; other site 441620003579 D-loop; other site 441620003580 H-loop/switch region; other site 441620003581 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 441620003582 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 441620003583 TM-ABC transporter signature motif; other site 441620003584 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 441620003585 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 441620003586 TM-ABC transporter signature motif; other site 441620003587 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 441620003588 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 441620003589 ligand binding site [chemical binding]; other site 441620003590 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 441620003591 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 441620003592 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 441620003593 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441620003594 ATP binding site [chemical binding]; other site 441620003595 putative Mg++ binding site [ion binding]; other site 441620003596 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441620003597 nucleotide binding region [chemical binding]; other site 441620003598 ATP-binding site [chemical binding]; other site 441620003599 TRCF domain; Region: TRCF; pfam03461 441620003600 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 441620003601 Cytochrome P450; Region: p450; cl12078 441620003602 nickel responsive regulator; Provisional; Region: PRK02967 441620003603 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 441620003604 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 441620003605 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620003606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620003607 active site 441620003608 phosphorylation site [posttranslational modification] 441620003609 intermolecular recognition site; other site 441620003610 dimerization interface [polypeptide binding]; other site 441620003611 CheB methylesterase; Region: CheB_methylest; pfam01339 441620003612 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 441620003613 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 441620003614 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 441620003615 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 441620003616 PAS domain; Region: PAS_10; pfam13596 441620003617 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620003618 PAS fold; Region: PAS_3; pfam08447 441620003619 putative active site [active] 441620003620 heme pocket [chemical binding]; other site 441620003621 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620003622 HWE histidine kinase; Region: HWE_HK; smart00911 441620003623 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 441620003624 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 441620003625 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 441620003626 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 441620003627 CheB methylesterase; Region: CheB_methylest; pfam01339 441620003628 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 441620003629 Ligand Binding Site [chemical binding]; other site 441620003630 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 441620003631 Ligand Binding Site [chemical binding]; other site 441620003632 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 441620003633 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 441620003634 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441620003635 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441620003636 ligand binding site [chemical binding]; other site 441620003637 flexible hinge region; other site 441620003638 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 441620003639 putative switch regulator; other site 441620003640 non-specific DNA interactions [nucleotide binding]; other site 441620003641 DNA binding site [nucleotide binding] 441620003642 sequence specific DNA binding site [nucleotide binding]; other site 441620003643 putative cAMP binding site [chemical binding]; other site 441620003644 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 441620003645 Walker A/P-loop; other site 441620003646 ATP binding site [chemical binding]; other site 441620003647 ABC transporter; Region: ABC_tran; pfam00005 441620003648 Q-loop/lid; other site 441620003649 ABC transporter signature motif; other site 441620003650 Walker B; other site 441620003651 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441620003652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 441620003653 Walker A/P-loop; other site 441620003654 ATP binding site [chemical binding]; other site 441620003655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620003656 ABC transporter signature motif; other site 441620003657 Walker B; other site 441620003658 D-loop; other site 441620003659 H-loop/switch region; other site 441620003660 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 441620003661 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 441620003662 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 441620003663 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 441620003664 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 441620003665 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 441620003666 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 441620003667 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 441620003668 Amidase; Region: Amidase; cl11426 441620003669 Amidase; Region: Amidase; cl11426 441620003670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620003671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620003672 dimer interface [polypeptide binding]; other site 441620003673 phosphorylation site [posttranslational modification] 441620003674 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620003675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620003676 active site 441620003677 phosphorylation site [posttranslational modification] 441620003678 intermolecular recognition site; other site 441620003679 dimerization interface [polypeptide binding]; other site 441620003680 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 441620003681 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 441620003682 DXD motif; other site 441620003683 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 441620003684 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 441620003685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 441620003686 TPR motif; other site 441620003687 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 441620003688 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 441620003689 putative NAD(P) binding site [chemical binding]; other site 441620003690 active site 441620003691 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620003692 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 441620003693 dimerization interface [polypeptide binding]; other site 441620003694 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 441620003695 active site 1 [active] 441620003696 dimer interface [polypeptide binding]; other site 441620003697 hexamer interface [polypeptide binding]; other site 441620003698 active site 2 [active] 441620003699 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 441620003700 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 441620003701 primosome assembly protein PriA; Validated; Region: PRK05580 441620003702 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441620003703 ATP binding site [chemical binding]; other site 441620003704 putative Mg++ binding site [ion binding]; other site 441620003705 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 441620003706 short chain dehydrogenase; Provisional; Region: PRK07109 441620003707 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 441620003708 putative NAD(P) binding site [chemical binding]; other site 441620003709 active site 441620003710 Isochorismatase family; Region: Isochorismatase; pfam00857 441620003711 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 441620003712 catalytic triad [active] 441620003713 conserved cis-peptide bond; other site 441620003714 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 441620003715 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 441620003716 NAD binding site [chemical binding]; other site 441620003717 catalytic Zn binding site [ion binding]; other site 441620003718 structural Zn binding site [ion binding]; other site 441620003719 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 441620003720 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 441620003721 short chain dehydrogenase; Provisional; Region: PRK06701 441620003722 NAD binding site [chemical binding]; other site 441620003723 metal binding site [ion binding]; metal-binding site 441620003724 active site 441620003725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620003726 NAD(P) binding site [chemical binding]; other site 441620003727 active site 441620003728 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 441620003729 ABC1 family; Region: ABC1; pfam03109 441620003730 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 441620003731 active site 441620003732 ATP binding site [chemical binding]; other site 441620003733 Predicted transporter component [General function prediction only]; Region: COG2391 441620003734 Sulphur transport; Region: Sulf_transp; pfam04143 441620003735 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 441620003736 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 441620003737 Zn binding site [ion binding]; other site 441620003738 Helix-turn-helix domain; Region: HTH_17; pfam12728 441620003739 Replication protein; Region: Rep_1; cl02412 441620003740 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 441620003741 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 441620003742 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 441620003743 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 441620003744 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 441620003745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 441620003746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 441620003747 Transposase; Region: DEDD_Tnp_IS110; pfam01548 441620003748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 441620003749 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 441620003750 CHASE3 domain; Region: CHASE3; pfam05227 441620003751 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441620003752 dimerization interface [polypeptide binding]; other site 441620003753 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620003754 dimer interface [polypeptide binding]; other site 441620003755 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 441620003756 putative CheW interface [polypeptide binding]; other site 441620003757 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441620003758 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441620003759 DNA binding residues [nucleotide binding] 441620003760 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 441620003761 RAMP superfamily; Region: RAMPs; pfam03787 441620003762 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441620003763 active site 441620003764 DNA binding site [nucleotide binding] 441620003765 Int/Topo IB signature motif; other site 441620003766 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620003767 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441620003768 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 441620003769 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620003770 Methyltransferase domain; Region: Methyltransf_23; pfam13489 441620003771 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 441620003772 Putative zinc-finger; Region: zf-HC2; pfam13490 441620003773 RNA polymerase sigma factor; Provisional; Region: PRK12511 441620003774 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441620003775 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441620003776 DNA binding residues [nucleotide binding] 441620003777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 441620003778 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441620003779 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441620003780 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 441620003781 Protein of unknown function (DUF461); Region: DUF461; pfam04314 441620003782 Protein of unknown function (DUF461); Region: DUF461; pfam04314 441620003783 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 441620003784 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 441620003785 Cu(I) binding site [ion binding]; other site 441620003786 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 441620003787 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620003788 N-terminal plug; other site 441620003789 ligand-binding site [chemical binding]; other site 441620003790 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 441620003791 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 441620003792 putative active site [active] 441620003793 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 441620003794 Transcriptional regulators [Transcription]; Region: GntR; COG1802 441620003795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441620003796 DNA-binding site [nucleotide binding]; DNA binding site 441620003797 FCD domain; Region: FCD; pfam07729 441620003798 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 441620003799 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 441620003800 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 441620003801 DctM-like transporters; Region: DctM; pfam06808 441620003802 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 441620003803 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 441620003804 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 441620003805 dimer interface [polypeptide binding]; other site 441620003806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620003807 catalytic residue [active] 441620003808 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 441620003809 MG2 domain; Region: A2M_N; pfam01835 441620003810 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 441620003811 surface patch; other site 441620003812 thioester region; other site 441620003813 specificity defining residues; other site 441620003814 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 441620003815 Transglycosylase; Region: Transgly; pfam00912 441620003816 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 441620003817 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 441620003818 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 441620003819 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620003820 sequence-specific DNA binding site [nucleotide binding]; other site 441620003821 salt bridge; other site 441620003822 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 441620003823 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 441620003824 active site 441620003825 catalytic site [active] 441620003826 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 441620003827 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 441620003828 vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461 441620003829 metal ion-dependent adhesion site (MIDAS); other site 441620003830 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 441620003831 catalytic core [active] 441620003832 High-affinity nickel-transport protein; Region: NicO; cl00964 441620003833 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 441620003834 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 441620003835 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 441620003836 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 441620003837 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 441620003838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 441620003839 TPR motif; other site 441620003840 binding surface 441620003841 sensor protein PhoQ; Provisional; Region: PRK10815 441620003842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620003843 ATP binding site [chemical binding]; other site 441620003844 Mg2+ binding site [ion binding]; other site 441620003845 G-X-G motif; other site 441620003846 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 441620003847 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 441620003848 putative active site [active] 441620003849 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441620003850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620003851 active site 441620003852 phosphorylation site [posttranslational modification] 441620003853 intermolecular recognition site; other site 441620003854 dimerization interface [polypeptide binding]; other site 441620003855 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620003856 DNA binding site [nucleotide binding] 441620003857 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 441620003858 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 441620003859 catalytic residues [active] 441620003860 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 441620003861 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 441620003862 Putative phage tail protein; Region: Phage-tail_3; pfam13550 441620003863 NlpC/P60 family; Region: NLPC_P60; cl17555 441620003864 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 441620003865 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 441620003866 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 441620003867 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 441620003868 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 441620003869 Phage-related minor tail protein [Function unknown]; Region: COG5281 441620003870 Conserved hypothetical phage protein (DUF2376); Region: DUF2376; pfam09550 441620003871 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 441620003872 Phage major tail protein 2; Region: Phage_tail_2; cl11463 441620003873 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 441620003874 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 441620003875 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 441620003876 oligomerization interface [polypeptide binding]; other site 441620003877 Trypsin; Region: Trypsin; pfam00089 441620003878 active site 441620003879 substrate binding sites [chemical binding]; other site 441620003880 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 441620003881 active site 441620003882 substrate binding sites [chemical binding]; other site 441620003883 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 441620003884 Phage capsid family; Region: Phage_capsid; pfam05065 441620003885 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 441620003886 Phage-related protein [Function unknown]; Region: COG4695 441620003887 Phage portal protein; Region: Phage_portal; pfam04860 441620003888 Uncharacterized conserved protein [Function unknown]; Region: COG5323 441620003889 Terminase-like family; Region: Terminase_6; pfam03237 441620003890 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 441620003891 active site 441620003892 SAM binding site [chemical binding]; other site 441620003893 homodimer interface [polypeptide binding]; other site 441620003894 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 441620003895 active site 441620003896 SAM binding site [chemical binding]; other site 441620003897 homodimer interface [polypeptide binding]; other site 441620003898 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 441620003899 Precorrin-8X methylmutase; Region: CbiC; pfam02570 441620003900 precorrin-3B synthase; Region: CobG; TIGR02435 441620003901 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 441620003902 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321 441620003903 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 441620003904 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 441620003905 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 441620003906 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 441620003907 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 441620003908 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 441620003909 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 441620003910 cobalt transporter subunit CbtA (proposed); Region: CbtA; TIGR02458 441620003911 cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459 441620003912 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 441620003913 homotrimer interface [polypeptide binding]; other site 441620003914 Walker A motif; other site 441620003915 GTP binding site [chemical binding]; other site 441620003916 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 441620003917 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 441620003918 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 441620003919 homodimer interface [polypeptide binding]; other site 441620003920 Walker A motif; other site 441620003921 ATP binding site [chemical binding]; other site 441620003922 hydroxycobalamin binding site [chemical binding]; other site 441620003923 Walker B motif; other site 441620003924 LabA_like proteins; Region: LabA_like; cd06167 441620003925 putative metal binding site [ion binding]; other site 441620003926 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 441620003927 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 441620003928 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 441620003929 PAS fold; Region: PAS_3; pfam08447 441620003930 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620003931 PAS domain; Region: PAS_9; pfam13426 441620003932 putative active site [active] 441620003933 heme pocket [chemical binding]; other site 441620003934 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620003935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620003936 dimer interface [polypeptide binding]; other site 441620003937 phosphorylation site [posttranslational modification] 441620003938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620003939 ATP binding site [chemical binding]; other site 441620003940 Mg2+ binding site [ion binding]; other site 441620003941 G-X-G motif; other site 441620003942 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620003943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620003944 active site 441620003945 phosphorylation site [posttranslational modification] 441620003946 intermolecular recognition site; other site 441620003947 dimerization interface [polypeptide binding]; other site 441620003948 Cupin; Region: Cupin_6; pfam12852 441620003949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441620003950 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441620003951 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441620003952 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 441620003953 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 441620003954 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 441620003955 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 441620003956 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 441620003957 Protein of unknown function DUF58; Region: DUF58; pfam01882 441620003958 MoxR-like ATPases [General function prediction only]; Region: COG0714 441620003959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 441620003960 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 441620003961 CoenzymeA binding site [chemical binding]; other site 441620003962 subunit interaction site [polypeptide binding]; other site 441620003963 PHB binding site; other site 441620003964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 441620003965 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 441620003966 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 441620003967 putative active site [active] 441620003968 putative CoA binding site [chemical binding]; other site 441620003969 nudix motif; other site 441620003970 metal binding site [ion binding]; metal-binding site 441620003971 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 441620003972 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 441620003973 active site 441620003974 NTP binding site [chemical binding]; other site 441620003975 metal binding triad [ion binding]; metal-binding site 441620003976 stationary phase growth adaptation protein; Provisional; Region: PRK09717 441620003977 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14736 441620003978 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 441620003979 gamma subunit interface [polypeptide binding]; other site 441620003980 epsilon subunit interface [polypeptide binding]; other site 441620003981 LBP interface [polypeptide binding]; other site 441620003982 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 441620003983 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 441620003984 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 441620003985 alpha subunit interaction interface [polypeptide binding]; other site 441620003986 Walker A motif; other site 441620003987 ATP binding site [chemical binding]; other site 441620003988 Walker B motif; other site 441620003989 inhibitor binding site; inhibition site 441620003990 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 441620003991 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 441620003992 core domain interface [polypeptide binding]; other site 441620003993 delta subunit interface [polypeptide binding]; other site 441620003994 epsilon subunit interface [polypeptide binding]; other site 441620003995 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 441620003996 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 441620003997 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 441620003998 beta subunit interaction interface [polypeptide binding]; other site 441620003999 Walker A motif; other site 441620004000 ATP binding site [chemical binding]; other site 441620004001 Walker B motif; other site 441620004002 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 441620004003 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 441620004004 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 441620004005 ferrochelatase; Reviewed; Region: hemH; PRK00035 441620004006 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 441620004007 C-terminal domain interface [polypeptide binding]; other site 441620004008 active site 441620004009 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 441620004010 active site 441620004011 N-terminal domain interface [polypeptide binding]; other site 441620004012 Methyltransferase domain; Region: Methyltransf_23; pfam13489 441620004013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620004014 S-adenosylmethionine binding site [chemical binding]; other site 441620004015 pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953 441620004016 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 441620004017 active site 441620004018 metal binding site [ion binding]; metal-binding site 441620004019 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 441620004020 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 441620004021 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 441620004022 ligand binding site [chemical binding]; other site 441620004023 active site 441620004024 UGI interface [polypeptide binding]; other site 441620004025 catalytic site [active] 441620004026 Response regulator receiver domain; Region: Response_reg; pfam00072 441620004027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620004028 active site 441620004029 phosphorylation site [posttranslational modification] 441620004030 intermolecular recognition site; other site 441620004031 dimerization interface [polypeptide binding]; other site 441620004032 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 441620004033 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 441620004034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 441620004035 ATP binding site [chemical binding]; other site 441620004036 putative Mg++ binding site [ion binding]; other site 441620004037 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 441620004038 SEC-C motif; Region: SEC-C; pfam02810 441620004039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441620004040 Coenzyme A binding pocket [chemical binding]; other site 441620004041 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 441620004042 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 441620004043 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 441620004044 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 441620004045 nudix motif; other site 441620004046 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 441620004047 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 441620004048 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 441620004049 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 441620004050 active site 441620004051 catalytic site [active] 441620004052 substrate binding site [chemical binding]; other site 441620004053 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 441620004054 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 441620004055 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 441620004056 CoA-binding site [chemical binding]; other site 441620004057 ATP-binding [chemical binding]; other site 441620004058 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 441620004059 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 441620004060 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 441620004061 NAD(P) binding site [chemical binding]; other site 441620004062 shikimate binding site; other site 441620004063 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 441620004064 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 441620004065 putative active site [active] 441620004066 Protein of unknown function (DUF563); Region: DUF563; pfam04577 441620004067 PEP synthetase regulatory protein; Provisional; Region: PRK05339 441620004068 uroporphyrinogen decarboxylase; Validated; Region: hemE; PRK00115 441620004069 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 441620004070 nudix motif; other site 441620004071 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 441620004072 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 441620004073 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 441620004074 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 441620004075 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 441620004076 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 441620004077 motif 1; other site 441620004078 dimer interface [polypeptide binding]; other site 441620004079 active site 441620004080 motif 2; other site 441620004081 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 441620004082 active site 441620004083 motif 3; other site 441620004084 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 441620004085 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 441620004086 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 441620004087 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 441620004088 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 441620004089 putative acyl-acceptor binding pocket; other site 441620004090 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441620004091 acyl-activating enzyme (AAE) consensus motif; other site 441620004092 AMP binding site [chemical binding]; other site 441620004093 active site 441620004094 CoA binding site [chemical binding]; other site 441620004095 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 441620004096 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 441620004097 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441620004098 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 441620004099 diiron binding motif [ion binding]; other site 441620004100 Uncharacterized conserved protein [Function unknown]; Region: COG1633 441620004101 CCC1-related protein family; Region: CCC1_like_1; cd02437 441620004102 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 441620004103 trimer interface [polypeptide binding]; other site 441620004104 putative metal binding site [ion binding]; other site 441620004105 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 441620004106 trimer interface [polypeptide binding]; other site 441620004107 putative metal binding site [ion binding]; other site 441620004108 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 441620004109 MoaE homodimer interface [polypeptide binding]; other site 441620004110 MoaD interaction [polypeptide binding]; other site 441620004111 active site residues [active] 441620004112 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 441620004113 malate:quinone oxidoreductase; Validated; Region: PRK05257 441620004114 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 441620004115 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 441620004116 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 441620004117 metal ion-dependent adhesion site (MIDAS); other site 441620004118 MoxR-like ATPases [General function prediction only]; Region: COG0714 441620004119 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 441620004120 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 441620004121 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 441620004122 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 441620004123 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 441620004124 putative uracil binding site [chemical binding]; other site 441620004125 putative active site [active] 441620004126 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 441620004127 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 441620004128 active site 441620004129 dimer interface [polypeptide binding]; other site 441620004130 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 441620004131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441620004132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441620004133 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 441620004134 classical (c) SDRs; Region: SDR_c; cd05233 441620004135 NAD(P) binding site [chemical binding]; other site 441620004136 active site 441620004137 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 441620004138 trimer interface [polypeptide binding]; other site 441620004139 active site 441620004140 Protein of unknown function (DUF429); Region: DUF429; cl12046 441620004141 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 441620004142 nudix motif; other site 441620004143 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 441620004144 active site clefts [active] 441620004145 zinc binding site [ion binding]; other site 441620004146 dimer interface [polypeptide binding]; other site 441620004147 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 441620004148 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 441620004149 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 441620004150 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 441620004151 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 441620004152 Ligand Binding Site [chemical binding]; other site 441620004153 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 441620004154 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 441620004155 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 441620004156 heme binding site [chemical binding]; other site 441620004157 ferroxidase pore; other site 441620004158 ferroxidase diiron center [ion binding]; other site 441620004159 methionine sulfoxide reductase A; Provisional; Region: PRK13014 441620004160 methionine sulfoxide reductase B; Provisional; Region: PRK00222 441620004161 SelR domain; Region: SelR; pfam01641 441620004162 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 441620004163 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 441620004164 Methyltransferase domain; Region: Methyltransf_23; pfam13489 441620004165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620004166 S-adenosylmethionine binding site [chemical binding]; other site 441620004167 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 441620004168 Protein of unknown function (DUF497); Region: DUF497; pfam04365 441620004169 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 441620004170 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 441620004171 putative acyl-acceptor binding pocket; other site 441620004172 Phosphotransferase enzyme family; Region: APH; pfam01636 441620004173 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 441620004174 active site 441620004175 substrate binding site [chemical binding]; other site 441620004176 ATP binding site [chemical binding]; other site 441620004177 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 441620004178 substrate binding site [chemical binding]; other site 441620004179 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 441620004180 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 441620004181 OmpW family; Region: OmpW; cl17427 441620004182 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620004183 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620004184 metal binding site [ion binding]; metal-binding site 441620004185 active site 441620004186 I-site; other site 441620004187 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 441620004188 Protein of unknown function (DUF808); Region: DUF808; cl01002 441620004189 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 441620004190 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 441620004191 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441620004192 catalytic residue [active] 441620004193 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441620004194 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441620004195 ligand binding site [chemical binding]; other site 441620004196 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 441620004197 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 441620004198 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 441620004199 trimer interface [polypeptide binding]; other site 441620004200 active site 441620004201 substrate binding site [chemical binding]; other site 441620004202 CoA binding site [chemical binding]; other site 441620004203 CHASE2 domain; Region: CHASE2; pfam05226 441620004204 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 441620004205 cyclase homology domain; Region: CHD; cd07302 441620004206 nucleotidyl binding site; other site 441620004207 metal binding site [ion binding]; metal-binding site 441620004208 dimer interface [polypeptide binding]; other site 441620004209 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 441620004210 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 441620004211 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 441620004212 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441620004213 active site 441620004214 FecR protein; Region: FecR; pfam04773 441620004215 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620004216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620004217 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 441620004218 dimerization interface [polypeptide binding]; other site 441620004219 Predicted amidohydrolase [General function prediction only]; Region: COG0388 441620004220 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 441620004221 putative active site [active] 441620004222 catalytic triad [active] 441620004223 putative dimer interface [polypeptide binding]; other site 441620004224 Protein of unknown function, DUF485; Region: DUF485; pfam04341 441620004225 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441620004226 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620004227 non-specific DNA binding site [nucleotide binding]; other site 441620004228 salt bridge; other site 441620004229 sequence-specific DNA binding site [nucleotide binding]; other site 441620004230 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 441620004231 active site 441620004232 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620004233 GAF domain; Region: GAF; pfam01590 441620004234 PAS domain; Region: PAS_9; pfam13426 441620004235 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620004236 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620004237 metal binding site [ion binding]; metal-binding site 441620004238 active site 441620004239 I-site; other site 441620004240 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 441620004241 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 441620004242 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 441620004243 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 441620004244 active site 441620004245 FMN binding site [chemical binding]; other site 441620004246 substrate binding site [chemical binding]; other site 441620004247 3Fe-4S cluster binding site [ion binding]; other site 441620004248 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 441620004249 domain_subunit interface; other site 441620004250 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 441620004251 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 441620004252 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 441620004253 active site 441620004254 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 441620004255 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 441620004256 conserved cys residue [active] 441620004257 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 441620004258 hydroxyglutarate oxidase; Provisional; Region: PRK11728 441620004259 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 441620004260 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 441620004261 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 441620004262 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 441620004263 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 441620004264 histidine kinase; Provisional; Region: PRK13557 441620004265 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620004266 putative active site [active] 441620004267 heme pocket [chemical binding]; other site 441620004268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620004269 dimer interface [polypeptide binding]; other site 441620004270 phosphorylation site [posttranslational modification] 441620004271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620004272 ATP binding site [chemical binding]; other site 441620004273 G-X-G motif; other site 441620004274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620004275 active site 441620004276 phosphorylation site [posttranslational modification] 441620004277 intermolecular recognition site; other site 441620004278 dimerization interface [polypeptide binding]; other site 441620004279 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 441620004280 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 441620004281 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441620004282 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 441620004283 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 441620004284 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 441620004285 E3 interaction surface; other site 441620004286 lipoyl attachment site [posttranslational modification]; other site 441620004287 e3 binding domain; Region: E3_binding; pfam02817 441620004288 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 441620004289 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 441620004290 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 441620004291 TPP-binding site [chemical binding]; other site 441620004292 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 441620004293 dimer interface [polypeptide binding]; other site 441620004294 PYR/PP interface [polypeptide binding]; other site 441620004295 TPP binding site [chemical binding]; other site 441620004296 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 441620004297 CoA binding domain; Region: CoA_binding; smart00881 441620004298 CoA-ligase; Region: Ligase_CoA; pfam00549 441620004299 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 441620004300 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 441620004301 CoA-ligase; Region: Ligase_CoA; pfam00549 441620004302 malate dehydrogenase; Reviewed; Region: PRK06223 441620004303 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 441620004304 NAD(P) binding site [chemical binding]; other site 441620004305 dimer interface [polypeptide binding]; other site 441620004306 tetramer (dimer of dimers) interface [polypeptide binding]; other site 441620004307 substrate binding site [chemical binding]; other site 441620004308 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441620004309 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441620004310 shikimate kinase; Provisional; Region: PRK13946 441620004311 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 441620004312 ADP binding site [chemical binding]; other site 441620004313 magnesium binding site [ion binding]; other site 441620004314 putative shikimate binding site; other site 441620004315 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 441620004316 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 441620004317 active site 441620004318 dimer interface [polypeptide binding]; other site 441620004319 metal binding site [ion binding]; metal-binding site 441620004320 addiction module antidote protein, HigA family; Region: antidote_HigA; TIGR02607 441620004321 sequence-specific DNA binding site [nucleotide binding]; other site 441620004322 salt bridge; other site 441620004323 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 441620004324 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 441620004325 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441620004326 FeS/SAM binding site; other site 441620004327 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 441620004328 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 441620004329 active site 441620004330 substrate-binding site [chemical binding]; other site 441620004331 metal-binding site [ion binding] 441620004332 ATP binding site [chemical binding]; other site 441620004333 recombination protein RecR; Reviewed; Region: recR; PRK00076 441620004334 RecR protein; Region: RecR; pfam02132 441620004335 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 441620004336 putative active site [active] 441620004337 putative metal-binding site [ion binding]; other site 441620004338 tetramer interface [polypeptide binding]; other site 441620004339 FAD binding domain; Region: FAD_binding_4; pfam01565 441620004340 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 441620004341 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 441620004342 classical (c) SDRs; Region: SDR_c; cd05233 441620004343 NAD(P) binding site [chemical binding]; other site 441620004344 active site 441620004345 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 441620004346 active site 441620004347 catalytic residues [active] 441620004348 metal binding site [ion binding]; metal-binding site 441620004349 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 441620004350 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 441620004351 putative active site [active] 441620004352 substrate binding site [chemical binding]; other site 441620004353 putative cosubstrate binding site; other site 441620004354 catalytic site [active] 441620004355 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 441620004356 substrate binding site [chemical binding]; other site 441620004357 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 441620004358 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 441620004359 dimerization interface 3.5A [polypeptide binding]; other site 441620004360 active site 441620004361 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 441620004362 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 441620004363 metal binding site [ion binding]; metal-binding site 441620004364 dimer interface [polypeptide binding]; other site 441620004365 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 441620004366 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 441620004367 ATP binding site [chemical binding]; other site 441620004368 substrate interface [chemical binding]; other site 441620004369 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 441620004370 SEC-C motif; Region: SEC-C; pfam02810 441620004371 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 441620004372 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 441620004373 putative tRNA-binding site [nucleotide binding]; other site 441620004374 B3/4 domain; Region: B3_4; pfam03483 441620004375 tRNA synthetase B5 domain; Region: B5; smart00874 441620004376 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 441620004377 dimer interface [polypeptide binding]; other site 441620004378 motif 1; other site 441620004379 motif 3; other site 441620004380 motif 2; other site 441620004381 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 441620004382 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 441620004383 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 441620004384 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 441620004385 dimer interface [polypeptide binding]; other site 441620004386 motif 1; other site 441620004387 active site 441620004388 motif 2; other site 441620004389 motif 3; other site 441620004390 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 441620004391 23S rRNA binding site [nucleotide binding]; other site 441620004392 L21 binding site [polypeptide binding]; other site 441620004393 L13 binding site [polypeptide binding]; other site 441620004394 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 441620004395 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620004396 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 441620004397 putative ADP-binding pocket [chemical binding]; other site 441620004398 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 441620004399 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 441620004400 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 441620004401 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 441620004402 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 441620004403 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 441620004404 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 441620004405 putative ADP-binding pocket [chemical binding]; other site 441620004406 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620004407 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 441620004408 Uncharacterized small protein [Function unknown]; Region: COG5568 441620004409 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 441620004410 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 441620004411 putative dimer interface [polypeptide binding]; other site 441620004412 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 441620004413 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 441620004414 TolR protein; Region: tolR; TIGR02801 441620004415 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 441620004416 putative active site [active] 441620004417 putative metal binding site [ion binding]; other site 441620004418 Flagellar protein FlaF; Region: FlaF; cl11454 441620004419 FlaG protein; Region: FlaG; cl00591 441620004420 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 441620004421 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 441620004422 ThiC-associated domain; Region: ThiC-associated; pfam13667 441620004423 ThiC family; Region: ThiC; pfam01964 441620004424 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 441620004425 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 441620004426 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 441620004427 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 441620004428 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 441620004429 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 441620004430 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 441620004431 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 441620004432 putative active site [active] 441620004433 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 441620004434 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 441620004435 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 441620004436 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 441620004437 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 441620004438 substrate binding pocket [chemical binding]; other site 441620004439 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 441620004440 B12 binding site [chemical binding]; other site 441620004441 cobalt ligand [ion binding]; other site 441620004442 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 441620004443 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 441620004444 FAD binding site [chemical binding]; other site 441620004445 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441620004446 putative DNA binding site [nucleotide binding]; other site 441620004447 putative Zn2+ binding site [ion binding]; other site 441620004448 Methyltransferase domain; Region: Methyltransf_31; pfam13847 441620004449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620004450 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 441620004451 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 441620004452 active site 441620004453 nucleophile elbow; other site 441620004454 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 441620004455 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 441620004456 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 441620004457 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 441620004458 potassium uptake protein; Region: kup; TIGR00794 441620004459 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 441620004460 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620004461 N-terminal plug; other site 441620004462 ligand-binding site [chemical binding]; other site 441620004463 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 441620004464 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441620004465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620004466 homodimer interface [polypeptide binding]; other site 441620004467 catalytic residue [active] 441620004468 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 441620004469 prephenate dehydrogenase; Validated; Region: PRK08507 441620004470 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 441620004471 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 441620004472 Lipopolysaccharide-assembly; Region: LptE; cl01125 441620004473 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 441620004474 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 441620004475 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 441620004476 ParB-like nuclease domain; Region: ParB; smart00470 441620004477 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 441620004478 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 441620004479 P-loop; other site 441620004480 Magnesium ion binding site [ion binding]; other site 441620004481 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 441620004482 Magnesium ion binding site [ion binding]; other site 441620004483 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 441620004484 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 441620004485 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 441620004486 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441620004487 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 441620004488 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 441620004489 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 441620004490 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 441620004491 trmE is a tRNA modification GTPase; Region: trmE; cd04164 441620004492 G1 box; other site 441620004493 GTP/Mg2+ binding site [chemical binding]; other site 441620004494 Switch I region; other site 441620004495 G2 box; other site 441620004496 Switch II region; other site 441620004497 G3 box; other site 441620004498 G4 box; other site 441620004499 G5 box; other site 441620004500 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 441620004501 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 441620004502 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 441620004503 HIGH motif; other site 441620004504 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 441620004505 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441620004506 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441620004507 active site 441620004508 KMSKS motif; other site 441620004509 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 441620004510 tRNA binding surface [nucleotide binding]; other site 441620004511 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 441620004512 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 441620004513 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441620004514 catalytic residue [active] 441620004515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 441620004516 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441620004517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620004518 active site 441620004519 phosphorylation site [posttranslational modification] 441620004520 intermolecular recognition site; other site 441620004521 dimerization interface [polypeptide binding]; other site 441620004522 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620004523 DNA binding site [nucleotide binding] 441620004524 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441620004525 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 441620004526 ligand binding site [chemical binding]; other site 441620004527 flexible hinge region; other site 441620004528 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 441620004529 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 441620004530 trimer interface [polypeptide binding]; other site 441620004531 active site 441620004532 substrate binding site [chemical binding]; other site 441620004533 CoA binding site [chemical binding]; other site 441620004534 Predicted transcriptional regulator [Transcription]; Region: COG2944 441620004535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 441620004536 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 441620004537 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 441620004538 active site 441620004539 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 441620004540 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 441620004541 putative lipid kinase; Reviewed; Region: PRK13057 441620004542 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 441620004543 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 441620004544 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 441620004545 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 441620004546 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 441620004547 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 441620004548 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620004549 N-terminal plug; other site 441620004550 ligand-binding site [chemical binding]; other site 441620004551 pyruvate dehydrogenase; Provisional; Region: PRK09124 441620004552 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 441620004553 PYR/PP interface [polypeptide binding]; other site 441620004554 tetramer interface [polypeptide binding]; other site 441620004555 dimer interface [polypeptide binding]; other site 441620004556 TPP binding site [chemical binding]; other site 441620004557 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 441620004558 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 441620004559 TPP-binding site [chemical binding]; other site 441620004560 transcription termination factor Rho; Provisional; Region: rho; PRK09376 441620004561 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 441620004562 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 441620004563 RNA binding site [nucleotide binding]; other site 441620004564 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 441620004565 multimer interface [polypeptide binding]; other site 441620004566 Walker A motif; other site 441620004567 ATP binding site [chemical binding]; other site 441620004568 Walker B motif; other site 441620004569 Smr domain; Region: Smr; pfam01713 441620004570 MltA specific insert domain; Region: MltA; smart00925 441620004571 3D domain; Region: 3D; pfam06725 441620004572 Tim44-like domain; Region: Tim44; pfam04280 441620004573 preprotein translocase subunit SecB; Validated; Region: PRK05751 441620004574 SecA binding site; other site 441620004575 Preprotein binding site; other site 441620004576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620004577 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441620004578 putative substrate translocation pore; other site 441620004579 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 441620004580 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 441620004581 dimer interface [polypeptide binding]; other site 441620004582 putative tRNA-binding site [nucleotide binding]; other site 441620004583 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 441620004584 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 441620004585 dimer interface [polypeptide binding]; other site 441620004586 motif 1; other site 441620004587 active site 441620004588 motif 2; other site 441620004589 motif 3; other site 441620004590 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 441620004591 anticodon binding site; other site 441620004592 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 441620004593 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 441620004594 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 441620004595 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 441620004596 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 441620004597 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 441620004598 active site 441620004599 homotetramer interface [polypeptide binding]; other site 441620004600 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 441620004601 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 441620004602 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 441620004603 active site 441620004604 catalytic site [active] 441620004605 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441620004606 active site 441620004607 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 441620004608 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 441620004609 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 441620004610 NAD(P) binding site [chemical binding]; other site 441620004611 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 441620004612 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 441620004613 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 441620004614 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 441620004615 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 441620004616 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 441620004617 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 441620004618 Ligand binding site [chemical binding]; other site 441620004619 Electron transfer flavoprotein domain; Region: ETF; pfam01012 441620004620 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 441620004621 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 441620004622 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 441620004623 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 441620004624 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 441620004625 UV-endonuclease UvdE; Region: UvdE; cl10036 441620004626 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 441620004627 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 441620004628 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 441620004629 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 441620004630 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 441620004631 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 441620004632 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 441620004633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620004634 active site 441620004635 phosphorylation site [posttranslational modification] 441620004636 intermolecular recognition site; other site 441620004637 dimerization interface [polypeptide binding]; other site 441620004638 CheB methylesterase; Region: CheB_methylest; pfam01339 441620004639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620004640 Response regulator receiver domain; Region: Response_reg; pfam00072 441620004641 active site 441620004642 phosphorylation site [posttranslational modification] 441620004643 intermolecular recognition site; other site 441620004644 dimerization interface [polypeptide binding]; other site 441620004645 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 441620004646 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 441620004647 putative binding surface; other site 441620004648 active site 441620004649 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 441620004650 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 441620004651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620004652 ATP binding site [chemical binding]; other site 441620004653 Mg2+ binding site [ion binding]; other site 441620004654 G-X-G motif; other site 441620004655 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 441620004656 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620004657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620004658 active site 441620004659 phosphorylation site [posttranslational modification] 441620004660 intermolecular recognition site; other site 441620004661 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 441620004662 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 441620004663 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 441620004664 active site 441620004665 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 441620004666 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 441620004667 diaminopimelate decarboxylase; Region: lysA; TIGR01048 441620004668 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 441620004669 active site 441620004670 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441620004671 substrate binding site [chemical binding]; other site 441620004672 catalytic residues [active] 441620004673 dimer interface [polypeptide binding]; other site 441620004674 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 441620004675 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 441620004676 hypothetical protein; Provisional; Region: PRK05415 441620004677 Domain of unknown function (DUF697); Region: DUF697; cl12064 441620004678 YcjX-like family, DUF463; Region: DUF463; pfam04317 441620004679 RES domain; Region: RES; pfam08808 441620004680 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 441620004681 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 441620004682 GAF domain; Region: GAF_2; pfam13185 441620004683 GAF domain; Region: GAF; pfam01590 441620004684 PAS domain; Region: PAS_9; pfam13426 441620004685 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 441620004686 PAS domain S-box; Region: sensory_box; TIGR00229 441620004687 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620004688 putative active site [active] 441620004689 heme pocket [chemical binding]; other site 441620004690 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 441620004691 PAS fold; Region: PAS_3; pfam08447 441620004692 putative active site [active] 441620004693 heme pocket [chemical binding]; other site 441620004694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620004695 dimer interface [polypeptide binding]; other site 441620004696 phosphorylation site [posttranslational modification] 441620004697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620004698 ATP binding site [chemical binding]; other site 441620004699 Mg2+ binding site [ion binding]; other site 441620004700 G-X-G motif; other site 441620004701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620004702 Response regulator receiver domain; Region: Response_reg; pfam00072 441620004703 active site 441620004704 phosphorylation site [posttranslational modification] 441620004705 intermolecular recognition site; other site 441620004706 dimerization interface [polypeptide binding]; other site 441620004707 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 441620004708 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 441620004709 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 441620004710 P-loop, Walker A motif; other site 441620004711 Base recognition motif; other site 441620004712 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 441620004713 Protein of unknown function DUF86; Region: DUF86; cl01031 441620004714 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 441620004715 active site 441620004716 NTP binding site [chemical binding]; other site 441620004717 metal binding triad [ion binding]; metal-binding site 441620004718 antibiotic binding site [chemical binding]; other site 441620004719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441620004720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441620004721 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441620004722 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 441620004723 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 441620004724 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 441620004725 active site residue [active] 441620004726 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 441620004727 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 441620004728 catalytic residues [active] 441620004729 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 441620004730 active site 441620004731 oligomerization interface [polypeptide binding]; other site 441620004732 metal binding site [ion binding]; metal-binding site 441620004733 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 441620004734 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 441620004735 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441620004736 FeS/SAM binding site; other site 441620004737 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 441620004738 RNA/DNA hybrid binding site [nucleotide binding]; other site 441620004739 active site 441620004740 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 441620004741 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 441620004742 putative active site [active] 441620004743 putative metal binding site [ion binding]; other site 441620004744 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 441620004745 homodimer interface [polypeptide binding]; other site 441620004746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620004747 catalytic residue [active] 441620004748 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 441620004749 glycerate dehydrogenase; Provisional; Region: PRK06487 441620004750 putative ligand binding site [chemical binding]; other site 441620004751 putative NAD binding site [chemical binding]; other site 441620004752 catalytic site [active] 441620004753 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 441620004754 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 441620004755 NADP binding site [chemical binding]; other site 441620004756 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 441620004757 malate--CoA ligase subunit beta; Provisional; Region: PRK14046 441620004758 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 441620004759 CoA-ligase; Region: Ligase_CoA; pfam00549 441620004760 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 441620004761 CoA binding domain; Region: CoA_binding; pfam02629 441620004762 CoA-ligase; Region: Ligase_CoA; pfam00549 441620004763 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 441620004764 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 441620004765 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 441620004766 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 441620004767 Dienelactone hydrolase family; Region: DLH; pfam01738 441620004768 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 441620004769 aromatic arch; other site 441620004770 DCoH dimer interaction site [polypeptide binding]; other site 441620004771 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 441620004772 DCoH tetramer interaction site [polypeptide binding]; other site 441620004773 substrate binding site [chemical binding]; other site 441620004774 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441620004775 substrate binding pocket [chemical binding]; other site 441620004776 membrane-bound complex binding site; other site 441620004777 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 441620004778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620004779 dimer interface [polypeptide binding]; other site 441620004780 conserved gate region; other site 441620004781 putative PBP binding loops; other site 441620004782 ABC-ATPase subunit interface; other site 441620004783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620004784 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441620004785 Walker A/P-loop; other site 441620004786 ATP binding site [chemical binding]; other site 441620004787 Q-loop/lid; other site 441620004788 ABC transporter signature motif; other site 441620004789 Walker B; other site 441620004790 D-loop; other site 441620004791 H-loop/switch region; other site 441620004792 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 441620004793 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 441620004794 Trp docking motif [polypeptide binding]; other site 441620004795 dimer interface [polypeptide binding]; other site 441620004796 active site 441620004797 small subunit binding site [polypeptide binding]; other site 441620004798 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 441620004799 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 441620004800 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 441620004801 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441620004802 substrate binding pocket [chemical binding]; other site 441620004803 membrane-bound complex binding site; other site 441620004804 hinge residues; other site 441620004805 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 441620004806 catalytic center binding site [active] 441620004807 ATP binding site [chemical binding]; other site 441620004808 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 441620004809 homooctamer interface [polypeptide binding]; other site 441620004810 active site 441620004811 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 441620004812 dihydropteroate synthase; Region: DHPS; TIGR01496 441620004813 substrate binding pocket [chemical binding]; other site 441620004814 dimer interface [polypeptide binding]; other site 441620004815 inhibitor binding site; inhibition site 441620004816 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 441620004817 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441620004818 FeS/SAM binding site; other site 441620004819 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 441620004820 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 441620004821 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 441620004822 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 441620004823 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 441620004824 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441620004825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620004826 active site 441620004827 phosphorylation site [posttranslational modification] 441620004828 intermolecular recognition site; other site 441620004829 dimerization interface [polypeptide binding]; other site 441620004830 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620004831 DNA binding site [nucleotide binding] 441620004832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620004833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620004834 dimer interface [polypeptide binding]; other site 441620004835 phosphorylation site [posttranslational modification] 441620004836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620004837 ATP binding site [chemical binding]; other site 441620004838 Mg2+ binding site [ion binding]; other site 441620004839 G-X-G motif; other site 441620004840 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 441620004841 domain_subunit interface; other site 441620004842 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 441620004843 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 441620004844 FTR, proximal lobe; Region: FTR_C; pfam02741 441620004845 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 441620004846 Formylmethanofuran dehydrogenase (FMDH) subunit A; Methanogenic bacteria and archea derive the energy for autotrophic growth from methanogenesis, the reduction of CO2 with molecular hydrogen as the electron donor. FMDH catalyzes the first step in...; Region: FMDH_A; cd01304 441620004847 active site 441620004848 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 441620004849 molybdopterin cofactor binding site; other site 441620004850 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 441620004851 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 441620004852 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 441620004853 NADP binding site [chemical binding]; other site 441620004854 ATP-grasp domain; Region: ATP-grasp_4; cl17255 441620004855 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 441620004856 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 441620004857 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 441620004858 trimer interface I [polypeptide binding]; other site 441620004859 putative substrate binding pocket [chemical binding]; other site 441620004860 trimer interface II [polypeptide binding]; other site 441620004861 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 441620004862 ATP-grasp domain; Region: ATP-grasp_4; cl17255 441620004863 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 441620004864 formaldehyde-activating enzyme; Region: one_C_fae; TIGR03126 441620004865 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 441620004866 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 441620004867 active site 441620004868 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 441620004869 Uncharacterized conserved protein [Function unknown]; Region: COG3391 441620004870 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 441620004871 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 441620004872 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 441620004873 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 441620004874 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 441620004875 putative hydrophobic ligand binding site [chemical binding]; other site 441620004876 protein interface [polypeptide binding]; other site 441620004877 gate; other site 441620004878 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 441620004879 putative hydrophobic ligand binding site [chemical binding]; other site 441620004880 protein interface [polypeptide binding]; other site 441620004881 gate; other site 441620004882 Protein of unknown function (DUF447); Region: DUF447; pfam04289 441620004883 dihydropteroate synthase-related protein; Region: TIGR00284 441620004884 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 441620004885 substrate binding pocket [chemical binding]; other site 441620004886 dimer interface [polypeptide binding]; other site 441620004887 inhibitor binding site; inhibition site 441620004888 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 441620004889 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 441620004890 nucleotide binding site [chemical binding]; other site 441620004891 substrate binding site [chemical binding]; other site 441620004892 hypothetical protein; Provisional; Region: PRK02227 441620004893 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 441620004894 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 441620004895 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 441620004896 ligand binding site [chemical binding]; other site 441620004897 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 441620004898 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 441620004899 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 441620004900 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 441620004901 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 441620004902 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 441620004903 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441620004904 Walker A/P-loop; other site 441620004905 ATP binding site [chemical binding]; other site 441620004906 Q-loop/lid; other site 441620004907 ABC transporter signature motif; other site 441620004908 Walker B; other site 441620004909 D-loop; other site 441620004910 H-loop/switch region; other site 441620004911 ABC-2 type transporter; Region: ABC2_membrane; cl17235 441620004912 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 441620004913 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 441620004914 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 441620004915 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 441620004916 Ca2+ binding site [ion binding]; other site 441620004917 hypothetical protein; Validated; Region: PRK00068 441620004918 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 441620004919 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 441620004920 NAD binding site [chemical binding]; other site 441620004921 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 441620004922 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620004923 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 441620004924 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 441620004925 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 441620004926 SLBB domain; Region: SLBB; pfam10531 441620004927 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 441620004928 Chain length determinant protein; Region: Wzz; pfam02706 441620004929 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 441620004930 hypothetical protein; Validated; Region: PRK00153 441620004931 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 441620004932 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 441620004933 active site 441620004934 DNA polymerase III subunit delta'; Validated; Region: PRK08485 441620004935 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 441620004936 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 441620004937 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 441620004938 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 441620004939 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 441620004940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620004941 Walker A motif; other site 441620004942 ATP binding site [chemical binding]; other site 441620004943 Walker B motif; other site 441620004944 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 441620004945 Uncharacterized conserved protein [Function unknown]; Region: COG3287 441620004946 FIST N domain; Region: FIST; pfam08495 441620004947 FIST C domain; Region: FIST_C; pfam10442 441620004948 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620004949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620004950 dimer interface [polypeptide binding]; other site 441620004951 phosphorylation site [posttranslational modification] 441620004952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620004953 ATP binding site [chemical binding]; other site 441620004954 Mg2+ binding site [ion binding]; other site 441620004955 G-X-G motif; other site 441620004956 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620004957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620004958 active site 441620004959 phosphorylation site [posttranslational modification] 441620004960 intermolecular recognition site; other site 441620004961 dimerization interface [polypeptide binding]; other site 441620004962 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 441620004963 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 441620004964 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 441620004965 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 441620004966 substrate binding pocket [chemical binding]; other site 441620004967 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 441620004968 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 441620004969 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441620004970 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441620004971 catalytic residue [active] 441620004972 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 441620004973 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 441620004974 putative [4Fe-4S] binding site [ion binding]; other site 441620004975 putative molybdopterin cofactor binding site [chemical binding]; other site 441620004976 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 441620004977 putative molybdopterin cofactor binding site; other site 441620004978 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 441620004979 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441620004980 Walker A/P-loop; other site 441620004981 ATP binding site [chemical binding]; other site 441620004982 Q-loop/lid; other site 441620004983 ABC transporter signature motif; other site 441620004984 Walker B; other site 441620004985 D-loop; other site 441620004986 H-loop/switch region; other site 441620004987 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 441620004988 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441620004989 Walker A/P-loop; other site 441620004990 ATP binding site [chemical binding]; other site 441620004991 Q-loop/lid; other site 441620004992 ABC transporter signature motif; other site 441620004993 Walker B; other site 441620004994 D-loop; other site 441620004995 H-loop/switch region; other site 441620004996 phosphopentomutase; Provisional; Region: PRK05362 441620004997 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 441620004998 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 441620004999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620005000 Walker A/P-loop; other site 441620005001 ATP binding site [chemical binding]; other site 441620005002 Q-loop/lid; other site 441620005003 ABC transporter signature motif; other site 441620005004 Walker B; other site 441620005005 D-loop; other site 441620005006 H-loop/switch region; other site 441620005007 ABC transporter; Region: ABC_tran_2; pfam12848 441620005008 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441620005009 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 441620005010 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 441620005011 active site 441620005012 substrate binding site [chemical binding]; other site 441620005013 Mg2+ binding site [ion binding]; other site 441620005014 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 441620005015 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 441620005016 TPP-binding site; other site 441620005017 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 441620005018 PYR/PP interface [polypeptide binding]; other site 441620005019 dimer interface [polypeptide binding]; other site 441620005020 TPP binding site [chemical binding]; other site 441620005021 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 441620005022 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 441620005023 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 441620005024 putative NADP binding site [chemical binding]; other site 441620005025 putative substrate binding site [chemical binding]; other site 441620005026 active site 441620005027 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 441620005028 active site lid residues [active] 441620005029 substrate binding pocket [chemical binding]; other site 441620005030 catalytic residues [active] 441620005031 substrate-Mg2+ binding site; other site 441620005032 aspartate-rich region 1; other site 441620005033 aspartate-rich region 2; other site 441620005034 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 441620005035 active site lid residues [active] 441620005036 substrate binding pocket [chemical binding]; other site 441620005037 catalytic residues [active] 441620005038 substrate-Mg2+ binding site; other site 441620005039 aspartate-rich region 1; other site 441620005040 aspartate-rich region 2; other site 441620005041 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 441620005042 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 441620005043 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 441620005044 Active site cavity [active] 441620005045 catalytic acid [active] 441620005046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441620005047 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 441620005048 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 441620005049 substrate-cofactor binding pocket; other site 441620005050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620005051 catalytic residue [active] 441620005052 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 441620005053 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 441620005054 active site 441620005055 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 441620005056 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 441620005057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620005058 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 441620005059 Enoylreductase; Region: PKS_ER; smart00829 441620005060 NAD(P) binding site [chemical binding]; other site 441620005061 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 441620005062 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 441620005063 putative NADP binding site [chemical binding]; other site 441620005064 active site 441620005065 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 441620005066 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 441620005067 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 441620005068 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 441620005069 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 441620005070 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 441620005071 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 441620005072 Probable Catalytic site; other site 441620005073 metal-binding site 441620005074 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 441620005075 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 441620005076 Probable Catalytic site; other site 441620005077 metal-binding site 441620005078 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 441620005079 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 441620005080 Protein of unknown function, DUF462; Region: DUF462; cl01190 441620005081 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 441620005082 mismatch recognition site; other site 441620005083 additional DNA contacts [nucleotide binding]; other site 441620005084 active site 441620005085 zinc binding site [ion binding]; other site 441620005086 DNA intercalation site [nucleotide binding]; other site 441620005087 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 441620005088 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 441620005089 cofactor binding site; other site 441620005090 DNA binding site [nucleotide binding] 441620005091 substrate interaction site [chemical binding]; other site 441620005092 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 441620005093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441620005094 Helix-turn-helix domain; Region: HTH_38; pfam13936 441620005095 BRO family, N-terminal domain; Region: Bro-N; smart01040 441620005096 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 441620005097 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 441620005098 catalytic residues [active] 441620005099 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 441620005100 putative homodimer interface [polypeptide binding]; other site 441620005101 putative homotetramer interface [polypeptide binding]; other site 441620005102 putative metal binding site [ion binding]; other site 441620005103 putative homodimer-homodimer interface [polypeptide binding]; other site 441620005104 putative allosteric switch controlling residues; other site 441620005105 H+ Antiporter protein; Region: 2A0121; TIGR00900 441620005106 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 441620005107 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620005108 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 441620005109 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 441620005110 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 441620005111 active site residue [active] 441620005112 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 441620005113 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 441620005114 Chromate transporter; Region: Chromate_transp; pfam02417 441620005115 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 441620005116 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 441620005117 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 441620005118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620005119 non-specific DNA binding site [nucleotide binding]; other site 441620005120 salt bridge; other site 441620005121 sequence-specific DNA binding site [nucleotide binding]; other site 441620005122 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 441620005123 active site 441620005124 catalytic residues [active] 441620005125 DNA binding site [nucleotide binding] 441620005126 Int/Topo IB signature motif; other site 441620005127 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 441620005128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620005129 putative substrate translocation pore; other site 441620005130 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 441620005131 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 441620005132 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 441620005133 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 441620005134 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 441620005135 Sel1-like repeats; Region: SEL1; smart00671 441620005136 Sel1-like repeats; Region: SEL1; smart00671 441620005137 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 441620005138 putative catalytic site [active] 441620005139 putative phosphate binding site [ion binding]; other site 441620005140 active site 441620005141 metal binding site A [ion binding]; metal-binding site 441620005142 DNA binding site [nucleotide binding] 441620005143 putative AP binding site [nucleotide binding]; other site 441620005144 putative metal binding site B [ion binding]; other site 441620005145 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 441620005146 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 441620005147 acyl-activating enzyme (AAE) consensus motif; other site 441620005148 putative AMP binding site [chemical binding]; other site 441620005149 putative active site [active] 441620005150 putative CoA binding site [chemical binding]; other site 441620005151 Uncharacterized small protein [Function unknown]; Region: COG5570 441620005152 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 441620005153 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 441620005154 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 441620005155 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 441620005156 ATP-grasp domain; Region: ATP-grasp; pfam02222 441620005157 TPR repeat; Region: TPR_11; pfam13414 441620005158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441620005159 binding surface 441620005160 TPR motif; other site 441620005161 TPR repeat; Region: TPR_11; pfam13414 441620005162 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441620005163 binding surface 441620005164 TPR motif; other site 441620005165 TPR repeat; Region: TPR_11; pfam13414 441620005166 Response regulator receiver domain; Region: Response_reg; pfam00072 441620005167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620005168 active site 441620005169 phosphorylation site [posttranslational modification] 441620005170 intermolecular recognition site; other site 441620005171 dimerization interface [polypeptide binding]; other site 441620005172 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 441620005173 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 441620005174 putative active site [active] 441620005175 homoserine dehydrogenase; Provisional; Region: PRK06349 441620005176 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 441620005177 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 441620005178 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 441620005179 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 441620005180 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 441620005181 Predicted methyltransferase [General function prediction only]; Region: COG3897 441620005182 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 441620005183 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620005184 putative ADP-binding pocket [chemical binding]; other site 441620005185 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 441620005186 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 441620005187 active site 441620005188 DNA binding site [nucleotide binding] 441620005189 Int/Topo IB signature motif; other site 441620005190 catalytic residues [active] 441620005191 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620005192 putative CheW interface [polypeptide binding]; other site 441620005193 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 441620005194 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441620005195 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441620005196 DNA binding residues [nucleotide binding] 441620005197 dimerization interface [polypeptide binding]; other site 441620005198 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620005199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620005200 active site 441620005201 phosphorylation site [posttranslational modification] 441620005202 intermolecular recognition site; other site 441620005203 dimerization interface [polypeptide binding]; other site 441620005204 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620005205 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620005206 metal binding site [ion binding]; metal-binding site 441620005207 active site 441620005208 I-site; other site 441620005209 Iron permease FTR1 family; Region: FTR1; cl00475 441620005210 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 441620005211 Low molecular weight phosphatase family; Region: LMWPc; cd00115 441620005212 active site 441620005213 hypothetical protein; Provisional; Region: PRK02853 441620005214 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 441620005215 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 441620005216 NAD binding site [chemical binding]; other site 441620005217 dimerization interface [polypeptide binding]; other site 441620005218 product binding site; other site 441620005219 substrate binding site [chemical binding]; other site 441620005220 zinc binding site [ion binding]; other site 441620005221 catalytic residues [active] 441620005222 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 441620005223 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 441620005224 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 441620005225 hinge; other site 441620005226 active site 441620005227 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 441620005228 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 441620005229 substrate-cofactor binding pocket; other site 441620005230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620005231 catalytic residue [active] 441620005232 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 441620005233 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 441620005234 PhnA protein; Region: PhnA; pfam03831 441620005235 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 441620005236 putative hydrolase; Provisional; Region: PRK02113 441620005237 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 441620005238 hypothetical protein; Provisional; Region: PRK11820 441620005239 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 441620005240 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 441620005241 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 441620005242 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 441620005243 catalytic site [active] 441620005244 G-X2-G-X-G-K; other site 441620005245 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441620005246 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441620005247 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 441620005248 Walker A/P-loop; other site 441620005249 ATP binding site [chemical binding]; other site 441620005250 Q-loop/lid; other site 441620005251 ABC transporter signature motif; other site 441620005252 Walker B; other site 441620005253 D-loop; other site 441620005254 H-loop/switch region; other site 441620005255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620005256 putative substrate translocation pore; other site 441620005257 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 441620005258 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 441620005259 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620005260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620005261 active site 441620005262 phosphorylation site [posttranslational modification] 441620005263 intermolecular recognition site; other site 441620005264 dimerization interface [polypeptide binding]; other site 441620005265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620005266 Response regulator receiver domain; Region: Response_reg; pfam00072 441620005267 active site 441620005268 phosphorylation site [posttranslational modification] 441620005269 intermolecular recognition site; other site 441620005270 dimerization interface [polypeptide binding]; other site 441620005271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 441620005272 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441620005273 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 441620005274 putative FMN binding site [chemical binding]; other site 441620005275 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 441620005276 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 441620005277 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620005278 N-terminal plug; other site 441620005279 ligand-binding site [chemical binding]; other site 441620005280 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 441620005281 active site 441620005282 intersubunit interface [polypeptide binding]; other site 441620005283 catalytic residue [active] 441620005284 phosphogluconate dehydratase; Validated; Region: PRK09054 441620005285 6-phosphogluconate dehydratase; Region: edd; TIGR01196 441620005286 Transcriptional regulators [Transcription]; Region: GntR; COG1802 441620005287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441620005288 DNA-binding site [nucleotide binding]; DNA binding site 441620005289 FCD domain; Region: FCD; pfam07729 441620005290 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 441620005291 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 441620005292 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 441620005293 putative ligand binding site [chemical binding]; other site 441620005294 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 441620005295 TM-ABC transporter signature motif; other site 441620005296 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 441620005297 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 441620005298 TM-ABC transporter signature motif; other site 441620005299 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 441620005300 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 441620005301 Walker A/P-loop; other site 441620005302 ATP binding site [chemical binding]; other site 441620005303 Q-loop/lid; other site 441620005304 ABC transporter signature motif; other site 441620005305 Walker B; other site 441620005306 D-loop; other site 441620005307 H-loop/switch region; other site 441620005308 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 441620005309 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 441620005310 Walker A/P-loop; other site 441620005311 ATP binding site [chemical binding]; other site 441620005312 Q-loop/lid; other site 441620005313 ABC transporter signature motif; other site 441620005314 Walker B; other site 441620005315 D-loop; other site 441620005316 H-loop/switch region; other site 441620005317 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 441620005318 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 441620005319 putative active site [active] 441620005320 putative catalytic site [active] 441620005321 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 441620005322 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 441620005323 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 441620005324 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 441620005325 dimerization interface [polypeptide binding]; other site 441620005326 domain crossover interface; other site 441620005327 redox-dependent activation switch; other site 441620005328 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 441620005329 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 441620005330 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 441620005331 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 441620005332 active site 441620005333 multimer interface [polypeptide binding]; other site 441620005334 Peptidase family M48; Region: Peptidase_M48; cl12018 441620005335 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 441620005336 Protein of unknown function (DUF466); Region: DUF466; pfam04328 441620005337 carbon starvation protein A; Provisional; Region: PRK15015 441620005338 Carbon starvation protein CstA; Region: CstA; pfam02554 441620005339 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 441620005340 Repair protein; Region: Repair_PSII; cl01535 441620005341 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 441620005342 Repair protein; Region: Repair_PSII; pfam04536 441620005343 LemA family; Region: LemA; pfam04011 441620005344 Rdx family; Region: Rdx; cl01407 441620005345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620005346 PAS domain; Region: PAS_9; pfam13426 441620005347 putative active site [active] 441620005348 heme pocket [chemical binding]; other site 441620005349 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620005350 HWE histidine kinase; Region: HWE_HK; pfam07536 441620005351 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 441620005352 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 441620005353 active site 441620005354 catalytic tetrad [active] 441620005355 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441620005356 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441620005357 ligand binding site [chemical binding]; other site 441620005358 flexible hinge region; other site 441620005359 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 441620005360 putative switch regulator; other site 441620005361 non-specific DNA interactions [nucleotide binding]; other site 441620005362 DNA binding site [nucleotide binding] 441620005363 sequence specific DNA binding site [nucleotide binding]; other site 441620005364 putative cAMP binding site [chemical binding]; other site 441620005365 glycogen synthase; Provisional; Region: glgA; PRK00654 441620005366 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 441620005367 ADP-binding pocket [chemical binding]; other site 441620005368 homodimer interface [polypeptide binding]; other site 441620005369 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 441620005370 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 441620005371 active site 441620005372 catalytic site [active] 441620005373 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 441620005374 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 441620005375 homodimer interface [polypeptide binding]; other site 441620005376 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 441620005377 active site pocket [active] 441620005378 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 441620005379 FAD binding pocket [chemical binding]; other site 441620005380 FAD binding motif [chemical binding]; other site 441620005381 phosphate binding motif [ion binding]; other site 441620005382 beta-alpha-beta structure motif; other site 441620005383 NAD binding pocket [chemical binding]; other site 441620005384 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 441620005385 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620005386 PAS fold; Region: PAS_3; pfam08447 441620005387 putative active site [active] 441620005388 heme pocket [chemical binding]; other site 441620005389 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620005390 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620005391 metal binding site [ion binding]; metal-binding site 441620005392 active site 441620005393 I-site; other site 441620005394 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 441620005395 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 441620005396 Mg++ binding site [ion binding]; other site 441620005397 putative catalytic motif [active] 441620005398 putative substrate binding site [chemical binding]; other site 441620005399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620005400 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 441620005401 NAD(P) binding site [chemical binding]; other site 441620005402 active site 441620005403 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 441620005404 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 441620005405 Predicted transcriptional regulators [Transcription]; Region: COG1733 441620005406 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 441620005407 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 441620005408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620005409 NAD(P) binding site [chemical binding]; other site 441620005410 active site 441620005411 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 441620005412 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 441620005413 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 441620005414 putative active site [active] 441620005415 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 441620005416 putative active site [active] 441620005417 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 441620005418 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 441620005419 Predicted acetyltransferase [General function prediction only]; Region: COG3153 441620005420 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 441620005421 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 441620005422 dimer interface [polypeptide binding]; other site 441620005423 active site 441620005424 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441620005425 catalytic residues [active] 441620005426 substrate binding site [chemical binding]; other site 441620005427 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 441620005428 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 441620005429 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 441620005430 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 441620005431 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 441620005432 FMN binding site [chemical binding]; other site 441620005433 active site 441620005434 substrate binding site [chemical binding]; other site 441620005435 catalytic residue [active] 441620005436 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 441620005437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441620005438 motif II; other site 441620005439 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 441620005440 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 441620005441 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 441620005442 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 441620005443 putative phosphate acyltransferase; Provisional; Region: PRK05331 441620005444 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 441620005445 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 441620005446 dimer interface [polypeptide binding]; other site 441620005447 active site 441620005448 CoA binding pocket [chemical binding]; other site 441620005449 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 441620005450 IHF dimer interface [polypeptide binding]; other site 441620005451 IHF - DNA interface [nucleotide binding]; other site 441620005452 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 441620005453 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 441620005454 DNA binding residues [nucleotide binding] 441620005455 PrkA family serine protein kinase; Provisional; Region: PRK15455 441620005456 AAA ATPase domain; Region: AAA_16; pfam13191 441620005457 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 441620005458 hypothetical protein; Provisional; Region: PRK05325 441620005459 SpoVR family protein; Provisional; Region: PRK11767 441620005460 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 441620005461 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 441620005462 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 441620005463 active site 441620005464 substrate binding site [chemical binding]; other site 441620005465 cosubstrate binding site; other site 441620005466 catalytic site [active] 441620005467 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 441620005468 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 441620005469 dimerization interface [polypeptide binding]; other site 441620005470 putative ATP binding site [chemical binding]; other site 441620005471 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 441620005472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 441620005473 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 441620005474 polyphosphate kinase; Provisional; Region: PRK05443 441620005475 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 441620005476 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 441620005477 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 441620005478 putative domain interface [polypeptide binding]; other site 441620005479 putative active site [active] 441620005480 catalytic site [active] 441620005481 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 441620005482 putative domain interface [polypeptide binding]; other site 441620005483 putative active site [active] 441620005484 catalytic site [active] 441620005485 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 441620005486 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 441620005487 aspartate aminotransferase; Provisional; Region: PRK05764 441620005488 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441620005489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620005490 homodimer interface [polypeptide binding]; other site 441620005491 catalytic residue [active] 441620005492 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 441620005493 Coenzyme A transferase; Region: CoA_trans; smart00882 441620005494 Coenzyme A transferase; Region: CoA_trans; cl17247 441620005495 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 441620005496 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441620005497 dimerization interface [polypeptide binding]; other site 441620005498 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620005499 dimer interface [polypeptide binding]; other site 441620005500 putative CheW interface [polypeptide binding]; other site 441620005501 30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311 441620005502 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 441620005503 rRNA interaction site [nucleotide binding]; other site 441620005504 S8 interaction site; other site 441620005505 putative laminin-1 binding site; other site 441620005506 Uncharacterized conserved protein [Function unknown]; Region: COG3743 441620005507 elongation factor Ts; Provisional; Region: tsf; PRK09377 441620005508 UBA/TS-N domain; Region: UBA; pfam00627 441620005509 Elongation factor TS; Region: EF_TS; pfam00889 441620005510 Elongation factor TS; Region: EF_TS; pfam00889 441620005511 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 441620005512 putative nucleotide binding site [chemical binding]; other site 441620005513 uridine monophosphate binding site [chemical binding]; other site 441620005514 homohexameric interface [polypeptide binding]; other site 441620005515 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 441620005516 dimer interface [polypeptide binding]; other site 441620005517 substrate binding site [chemical binding]; other site 441620005518 metal binding sites [ion binding]; metal-binding site 441620005519 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 441620005520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441620005521 Coenzyme A binding pocket [chemical binding]; other site 441620005522 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 441620005523 Putative phosphatase (DUF442); Region: DUF442; cl17385 441620005524 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 441620005525 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 441620005526 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 441620005527 trimer interface [polypeptide binding]; other site 441620005528 active site 441620005529 UDP-GlcNAc binding site [chemical binding]; other site 441620005530 lipid binding site [chemical binding]; lipid-binding site 441620005531 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 441620005532 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 441620005533 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 441620005534 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 441620005535 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 441620005536 Surface antigen; Region: Bac_surface_Ag; pfam01103 441620005537 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 441620005538 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 441620005539 active site 441620005540 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 441620005541 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 441620005542 putative substrate binding region [chemical binding]; other site 441620005543 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 441620005544 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 441620005545 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 441620005546 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 441620005547 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 441620005548 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 441620005549 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 441620005550 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 441620005551 catalytic residue [active] 441620005552 putative FPP diphosphate binding site; other site 441620005553 putative FPP binding hydrophobic cleft; other site 441620005554 dimer interface [polypeptide binding]; other site 441620005555 putative IPP diphosphate binding site; other site 441620005556 ribosome recycling factor; Reviewed; Region: frr; PRK00083 441620005557 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 441620005558 hinge region; other site 441620005559 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 441620005560 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620005561 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 441620005562 dimer interface [polypeptide binding]; other site 441620005563 putative CheW interface [polypeptide binding]; other site 441620005564 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 441620005565 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 441620005566 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 441620005567 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 441620005568 active site 441620005569 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 441620005570 catalytic triad [active] 441620005571 dimer interface [polypeptide binding]; other site 441620005572 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 441620005573 Nitrogen regulatory protein P-II; Region: P-II; smart00938 441620005574 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 441620005575 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 441620005576 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 441620005577 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 441620005578 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 441620005579 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 441620005580 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 441620005581 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 441620005582 PAS fold; Region: PAS_4; pfam08448 441620005583 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620005584 putative active site [active] 441620005585 PAS fold; Region: PAS_3; pfam08447 441620005586 heme pocket [chemical binding]; other site 441620005587 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620005588 HWE histidine kinase; Region: HWE_HK; smart00911 441620005589 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 441620005590 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 441620005591 putative molybdopterin cofactor binding site [chemical binding]; other site 441620005592 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 441620005593 putative molybdopterin cofactor binding site; other site 441620005594 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 441620005595 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 441620005596 quinone interaction residues [chemical binding]; other site 441620005597 active site 441620005598 catalytic residues [active] 441620005599 FMN binding site [chemical binding]; other site 441620005600 substrate binding site [chemical binding]; other site 441620005601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 441620005602 Predicted transcriptional regulator [Transcription]; Region: COG2932 441620005603 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 441620005604 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 441620005605 Catalytic site [active] 441620005606 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 441620005607 serine acetyltransferase; Provisional; Region: cysE; PRK11132 441620005608 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 441620005609 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 441620005610 trimer interface [polypeptide binding]; other site 441620005611 active site 441620005612 substrate binding site [chemical binding]; other site 441620005613 CoA binding site [chemical binding]; other site 441620005614 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 441620005615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620005616 non-specific DNA binding site [nucleotide binding]; other site 441620005617 salt bridge; other site 441620005618 sequence-specific DNA binding site [nucleotide binding]; other site 441620005619 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 441620005620 ADP binding site [chemical binding]; other site 441620005621 magnesium binding site [ion binding]; other site 441620005622 putative shikimate binding site; other site 441620005623 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 441620005624 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 441620005625 peptide binding site [polypeptide binding]; other site 441620005626 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620005627 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 441620005628 dimer interface [polypeptide binding]; other site 441620005629 phosphorylation site [posttranslational modification] 441620005630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620005631 ATP binding site [chemical binding]; other site 441620005632 Mg2+ binding site [ion binding]; other site 441620005633 G-X-G motif; other site 441620005634 osmolarity response regulator; Provisional; Region: ompR; PRK09468 441620005635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620005636 active site 441620005637 phosphorylation site [posttranslational modification] 441620005638 intermolecular recognition site; other site 441620005639 dimerization interface [polypeptide binding]; other site 441620005640 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620005641 DNA binding site [nucleotide binding] 441620005642 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620005643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620005644 active site 441620005645 phosphorylation site [posttranslational modification] 441620005646 intermolecular recognition site; other site 441620005647 dimerization interface [polypeptide binding]; other site 441620005648 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 441620005649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620005650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620005651 dimer interface [polypeptide binding]; other site 441620005652 phosphorylation site [posttranslational modification] 441620005653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620005654 ATP binding site [chemical binding]; other site 441620005655 Mg2+ binding site [ion binding]; other site 441620005656 G-X-G motif; other site 441620005657 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620005658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620005659 active site 441620005660 phosphorylation site [posttranslational modification] 441620005661 intermolecular recognition site; other site 441620005662 dimerization interface [polypeptide binding]; other site 441620005663 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620005664 GAF domain; Region: GAF; pfam01590 441620005665 GAF domain; Region: GAF; pfam01590 441620005666 GAF domain; Region: GAF_2; pfam13185 441620005667 PAS domain S-box; Region: sensory_box; TIGR00229 441620005668 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620005669 GAF domain; Region: GAF; pfam01590 441620005670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620005671 HWE histidine kinase; Region: HWE_HK; pfam07536 441620005672 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441620005673 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441620005674 ligand binding site [chemical binding]; other site 441620005675 flexible hinge region; other site 441620005676 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 441620005677 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 441620005678 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 441620005679 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 441620005680 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620005681 N-terminal plug; other site 441620005682 ligand-binding site [chemical binding]; other site 441620005683 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 441620005684 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 441620005685 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 441620005686 Moco binding site; other site 441620005687 metal coordination site [ion binding]; other site 441620005688 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 441620005689 FAD binding pocket [chemical binding]; other site 441620005690 conserved FAD binding motif [chemical binding]; other site 441620005691 phosphate binding motif [ion binding]; other site 441620005692 beta-alpha-beta structure motif; other site 441620005693 NAD binding pocket [chemical binding]; other site 441620005694 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 441620005695 TIGR02300 family protein; Region: FYDLN_acid 441620005696 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 441620005697 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 441620005698 hinge; other site 441620005699 active site 441620005700 cytidylate kinase; Provisional; Region: cmk; PRK00023 441620005701 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 441620005702 CMP-binding site; other site 441620005703 The sites determining sugar specificity; other site 441620005704 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 441620005705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620005706 PAS domain; Region: PAS_9; pfam13426 441620005707 putative active site [active] 441620005708 heme pocket [chemical binding]; other site 441620005709 PAS fold; Region: PAS_7; pfam12860 441620005710 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620005711 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620005712 metal binding site [ion binding]; metal-binding site 441620005713 active site 441620005714 I-site; other site 441620005715 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 441620005716 DNA ligase; Provisional; Region: 30; PHA02587 441620005717 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 441620005718 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 441620005719 homodimer interface [polypeptide binding]; other site 441620005720 active site 441620005721 TDP-binding site; other site 441620005722 acceptor substrate-binding pocket; other site 441620005723 Creatinine amidohydrolase; Region: Creatininase; pfam02633 441620005724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620005725 PAS domain; Region: PAS_9; pfam13426 441620005726 putative active site [active] 441620005727 heme pocket [chemical binding]; other site 441620005728 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620005729 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620005730 metal binding site [ion binding]; metal-binding site 441620005731 active site 441620005732 I-site; other site 441620005733 CsbD-like; Region: CsbD; pfam05532 441620005734 CsbD-like; Region: CsbD; pfam05532 441620005735 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 441620005736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620005737 putative substrate translocation pore; other site 441620005738 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 441620005739 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 441620005740 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 441620005741 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 441620005742 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 441620005743 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 441620005744 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 441620005745 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441620005746 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 441620005747 acyl-activating enzyme (AAE) consensus motif; other site 441620005748 putative AMP binding site [chemical binding]; other site 441620005749 putative active site [active] 441620005750 putative CoA binding site [chemical binding]; other site 441620005751 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 441620005752 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620005753 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 441620005754 dimerization interface [polypeptide binding]; other site 441620005755 substrate binding pocket [chemical binding]; other site 441620005756 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 441620005757 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 441620005758 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 441620005759 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441620005760 motif II; other site 441620005761 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 441620005762 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620005763 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620005764 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 441620005765 putative effector binding pocket; other site 441620005766 dimerization interface [polypeptide binding]; other site 441620005767 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 441620005768 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 441620005769 Zn binding site [ion binding]; other site 441620005770 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 441620005771 Zn binding site [ion binding]; other site 441620005772 Predicted esterase [General function prediction only]; Region: COG0400 441620005773 putative hydrolase; Provisional; Region: PRK11460 441620005774 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441620005775 MarR family; Region: MarR; pfam01047 441620005776 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441620005777 Coenzyme A binding pocket [chemical binding]; other site 441620005778 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 441620005779 AAA domain; Region: AAA_23; pfam13476 441620005780 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 441620005781 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 441620005782 S17 interaction site [polypeptide binding]; other site 441620005783 S8 interaction site; other site 441620005784 16S rRNA interaction site [nucleotide binding]; other site 441620005785 streptomycin interaction site [chemical binding]; other site 441620005786 23S rRNA interaction site [nucleotide binding]; other site 441620005787 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 441620005788 30S ribosomal protein S7; Validated; Region: PRK05302 441620005789 elongation factor G; Reviewed; Region: PRK00007 441620005790 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 441620005791 G1 box; other site 441620005792 putative GEF interaction site [polypeptide binding]; other site 441620005793 GTP/Mg2+ binding site [chemical binding]; other site 441620005794 Switch I region; other site 441620005795 G2 box; other site 441620005796 G3 box; other site 441620005797 Switch II region; other site 441620005798 G4 box; other site 441620005799 G5 box; other site 441620005800 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 441620005801 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 441620005802 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 441620005803 elongation factor Tu; Reviewed; Region: PRK00049 441620005804 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 441620005805 G1 box; other site 441620005806 GEF interaction site [polypeptide binding]; other site 441620005807 GTP/Mg2+ binding site [chemical binding]; other site 441620005808 Switch I region; other site 441620005809 G2 box; other site 441620005810 G3 box; other site 441620005811 Switch II region; other site 441620005812 G4 box; other site 441620005813 G5 box; other site 441620005814 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 441620005815 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 441620005816 Antibiotic Binding Site [chemical binding]; other site 441620005817 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 441620005818 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 441620005819 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 441620005820 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 441620005821 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 441620005822 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 441620005823 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 441620005824 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 441620005825 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 441620005826 putative translocon binding site; other site 441620005827 protein-rRNA interface [nucleotide binding]; other site 441620005828 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 441620005829 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 441620005830 G-X-X-G motif; other site 441620005831 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 441620005832 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 441620005833 23S rRNA interface [nucleotide binding]; other site 441620005834 5S rRNA interface [nucleotide binding]; other site 441620005835 putative antibiotic binding site [chemical binding]; other site 441620005836 L25 interface [polypeptide binding]; other site 441620005837 L27 interface [polypeptide binding]; other site 441620005838 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 441620005839 23S rRNA interface [nucleotide binding]; other site 441620005840 putative translocon interaction site; other site 441620005841 signal recognition particle (SRP54) interaction site; other site 441620005842 L23 interface [polypeptide binding]; other site 441620005843 trigger factor interaction site; other site 441620005844 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 441620005845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620005846 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 441620005847 Walker A motif; other site 441620005848 ATP binding site [chemical binding]; other site 441620005849 Walker B motif; other site 441620005850 arginine finger; other site 441620005851 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 441620005852 Predicted membrane protein [Function unknown]; Region: COG4655 441620005853 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 441620005854 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 441620005855 nudix motif; other site 441620005856 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441620005857 MarR family; Region: MarR; pfam01047 441620005858 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 441620005859 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 441620005860 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 441620005861 alphaNTD - beta interaction site [polypeptide binding]; other site 441620005862 alphaNTD homodimer interface [polypeptide binding]; other site 441620005863 alphaNTD - beta' interaction site [polypeptide binding]; other site 441620005864 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 441620005865 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 441620005866 30S ribosomal protein S11; Validated; Region: PRK05309 441620005867 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 441620005868 30S ribosomal protein S13; Region: bact_S13; TIGR03631 441620005869 adenylate kinase; Reviewed; Region: adk; PRK00279 441620005870 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 441620005871 AMP-binding site [chemical binding]; other site 441620005872 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 441620005873 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 441620005874 SecY translocase; Region: SecY; pfam00344 441620005875 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 441620005876 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 441620005877 23S rRNA binding site [nucleotide binding]; other site 441620005878 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 441620005879 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 441620005880 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 441620005881 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 441620005882 5S rRNA interface [nucleotide binding]; other site 441620005883 23S rRNA interface [nucleotide binding]; other site 441620005884 L5 interface [polypeptide binding]; other site 441620005885 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 441620005886 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 441620005887 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 441620005888 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 441620005889 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 441620005890 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 441620005891 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 441620005892 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 441620005893 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 441620005894 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 441620005895 RNA binding site [nucleotide binding]; other site 441620005896 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 441620005897 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 441620005898 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 441620005899 Catalytic site; other site 441620005900 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620005901 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620005902 metal binding site [ion binding]; metal-binding site 441620005903 active site 441620005904 I-site; other site 441620005905 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 441620005906 salicylate hydroxylase; Provisional; Region: PRK08163 441620005907 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 441620005908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 441620005909 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 441620005910 active site 441620005911 hypothetical protein; Reviewed; Region: PRK00024 441620005912 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 441620005913 MPN+ (JAMM) motif; other site 441620005914 Zinc-binding site [ion binding]; other site 441620005915 Uncharacterized conserved protein [Function unknown]; Region: COG2308 441620005916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 441620005917 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 441620005918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620005919 metabolite-proton symporter; Region: 2A0106; TIGR00883 441620005920 putative substrate translocation pore; other site 441620005921 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 441620005922 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 441620005923 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 441620005924 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 441620005925 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 441620005926 active site 441620005927 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 441620005928 NAD-dependent deacetylase; Provisional; Region: PRK00481 441620005929 NAD+ binding site [chemical binding]; other site 441620005930 substrate binding site [chemical binding]; other site 441620005931 Zn binding site [ion binding]; other site 441620005932 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 441620005933 Domain of unknown function DUF21; Region: DUF21; pfam01595 441620005934 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 441620005935 Transporter associated domain; Region: CorC_HlyC; smart01091 441620005936 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 441620005937 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 441620005938 Probable Catalytic site; other site 441620005939 metal-binding site 441620005940 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620005941 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441620005942 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620005943 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620005944 metal binding site [ion binding]; metal-binding site 441620005945 active site 441620005946 I-site; other site 441620005947 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 441620005948 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 441620005949 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 441620005950 protein binding site [polypeptide binding]; other site 441620005951 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 441620005952 protein binding site [polypeptide binding]; other site 441620005953 Phasin protein; Region: Phasin_2; cl11491 441620005954 phasin; Region: phasin_2; TIGR01985 441620005955 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620005956 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 441620005957 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620005958 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 441620005959 PAS domain S-box; Region: sensory_box; TIGR00229 441620005960 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620005961 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620005962 metal binding site [ion binding]; metal-binding site 441620005963 active site 441620005964 I-site; other site 441620005965 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 441620005966 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 441620005967 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 441620005968 active site 441620005969 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 441620005970 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 441620005971 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 441620005972 CysD dimerization site [polypeptide binding]; other site 441620005973 G1 box; other site 441620005974 putative GEF interaction site [polypeptide binding]; other site 441620005975 GTP/Mg2+ binding site [chemical binding]; other site 441620005976 Switch I region; other site 441620005977 G2 box; other site 441620005978 G3 box; other site 441620005979 Switch II region; other site 441620005980 G4 box; other site 441620005981 G5 box; other site 441620005982 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 441620005983 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 441620005984 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 441620005985 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 441620005986 Active Sites [active] 441620005987 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 441620005988 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 441620005989 Active Sites [active] 441620005990 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 441620005991 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441620005992 dimerization interface [polypeptide binding]; other site 441620005993 putative DNA binding site [nucleotide binding]; other site 441620005994 putative Zn2+ binding site [ion binding]; other site 441620005995 AsnC family; Region: AsnC_trans_reg; pfam01037 441620005996 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 441620005997 Flavodoxin; Region: Flavodoxin_1; pfam00258 441620005998 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 441620005999 FAD binding pocket [chemical binding]; other site 441620006000 FAD binding motif [chemical binding]; other site 441620006001 catalytic residues [active] 441620006002 NAD binding pocket [chemical binding]; other site 441620006003 phosphate binding motif [ion binding]; other site 441620006004 beta-alpha-beta structure motif; other site 441620006005 sulfite reductase subunit beta; Provisional; Region: PRK13504 441620006006 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 441620006007 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 441620006008 pantoate--beta-alanine ligase; Region: panC; TIGR00018 441620006009 Pantoate-beta-alanine ligase; Region: PanC; cd00560 441620006010 active site 441620006011 ATP-binding site [chemical binding]; other site 441620006012 pantoate-binding site; other site 441620006013 HXXH motif; other site 441620006014 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441620006015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620006016 non-specific DNA binding site [nucleotide binding]; other site 441620006017 salt bridge; other site 441620006018 sequence-specific DNA binding site [nucleotide binding]; other site 441620006019 Cupin domain; Region: Cupin_2; pfam07883 441620006020 Protein of unknown function (DUF3620); Region: DUF3620; pfam12281 441620006021 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 441620006022 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 441620006023 dimer interface [polypeptide binding]; other site 441620006024 ssDNA binding site [nucleotide binding]; other site 441620006025 tetramer (dimer of dimers) interface [polypeptide binding]; other site 441620006026 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 441620006027 Prostaglandin dehydrogenases; Region: PGDH; cd05288 441620006028 NAD(P) binding site [chemical binding]; other site 441620006029 substrate binding site [chemical binding]; other site 441620006030 dimer interface [polypeptide binding]; other site 441620006031 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 441620006032 Predicted periplasmic protein [Function unknown]; Region: COG3698 441620006033 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 441620006034 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 441620006035 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 441620006036 active site 441620006037 FMN binding site [chemical binding]; other site 441620006038 substrate binding site [chemical binding]; other site 441620006039 homotetramer interface [polypeptide binding]; other site 441620006040 catalytic residue [active] 441620006041 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 441620006042 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 441620006043 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 441620006044 putative dimer interface [polypeptide binding]; other site 441620006045 N-terminal domain interface [polypeptide binding]; other site 441620006046 putative substrate binding pocket (H-site) [chemical binding]; other site 441620006047 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 441620006048 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441620006049 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 441620006050 Uncharacterized conserved protein [Function unknown]; Region: COG2835 441620006051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 441620006052 PAS domain; Region: PAS_9; pfam13426 441620006053 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620006054 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620006055 dimer interface [polypeptide binding]; other site 441620006056 phosphorylation site [posttranslational modification] 441620006057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620006058 ATP binding site [chemical binding]; other site 441620006059 Mg2+ binding site [ion binding]; other site 441620006060 G-X-G motif; other site 441620006061 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 441620006062 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 441620006063 PilZ domain; Region: PilZ; pfam07238 441620006064 PilZ domain; Region: PilZ; pfam07238 441620006065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 441620006066 PAS domain; Region: PAS_5; pfam07310 441620006067 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 441620006068 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 441620006069 FOG: CBS domain [General function prediction only]; Region: COG0517 441620006070 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 441620006071 hypothetical protein; Provisional; Region: PRK10279 441620006072 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 441620006073 active site 441620006074 nucleophile elbow; other site 441620006075 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 441620006076 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 441620006077 GTP cyclohydrolase I; Provisional; Region: PLN03044 441620006078 active site 441620006079 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 441620006080 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 441620006081 trimerization site [polypeptide binding]; other site 441620006082 active site 441620006083 hypothetical protein; Validated; Region: PRK00041 441620006084 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 441620006085 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 441620006086 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 441620006087 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441620006088 FtsX-like permease family; Region: FtsX; pfam02687 441620006089 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441620006090 putative DNA binding site [nucleotide binding]; other site 441620006091 putative Zn2+ binding site [ion binding]; other site 441620006092 Fatty acid desaturase; Region: FA_desaturase; pfam00487 441620006093 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 441620006094 Di-iron ligands [ion binding]; other site 441620006095 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 441620006096 active site 441620006097 hydrophilic channel; other site 441620006098 dimerization interface [polypeptide binding]; other site 441620006099 catalytic residues [active] 441620006100 active site lid [active] 441620006101 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 441620006102 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 441620006103 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 441620006104 Catalytic site [active] 441620006105 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 441620006106 Catalytic site [active] 441620006107 ribonuclease III; Reviewed; Region: rnc; PRK00102 441620006108 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 441620006109 dimerization interface [polypeptide binding]; other site 441620006110 active site 441620006111 metal binding site [ion binding]; metal-binding site 441620006112 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 441620006113 dsRNA binding site [nucleotide binding]; other site 441620006114 GTPase Era; Reviewed; Region: era; PRK00089 441620006115 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 441620006116 G1 box; other site 441620006117 GTP/Mg2+ binding site [chemical binding]; other site 441620006118 Switch I region; other site 441620006119 G2 box; other site 441620006120 Switch II region; other site 441620006121 G3 box; other site 441620006122 G4 box; other site 441620006123 G5 box; other site 441620006124 KH domain; Region: KH_2; pfam07650 441620006125 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 441620006126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620006127 S-adenosylmethionine binding site [chemical binding]; other site 441620006128 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 441620006129 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441620006130 RNA binding surface [nucleotide binding]; other site 441620006131 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 441620006132 active site 441620006133 uracil binding [chemical binding]; other site 441620006134 potassium uptake protein; Region: kup; TIGR00794 441620006135 K+ potassium transporter; Region: K_trans; pfam02705 441620006136 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 441620006137 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 441620006138 putative active site [active] 441620006139 Ap4A binding site [chemical binding]; other site 441620006140 nudix motif; other site 441620006141 putative metal binding site [ion binding]; other site 441620006142 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 441620006143 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620006144 dimer interface [polypeptide binding]; other site 441620006145 putative CheW interface [polypeptide binding]; other site 441620006146 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 441620006147 NodB motif; other site 441620006148 putative active site [active] 441620006149 putative catalytic site [active] 441620006150 Zn binding site [ion binding]; other site 441620006151 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 441620006152 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 441620006153 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 441620006154 protein binding site [polypeptide binding]; other site 441620006155 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 441620006156 Catalytic dyad [active] 441620006157 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 441620006158 Peptidase family M23; Region: Peptidase_M23; pfam01551 441620006159 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 441620006160 citrate-proton symporter; Provisional; Region: PRK15075 441620006161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620006162 putative substrate translocation pore; other site 441620006163 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 441620006164 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620006165 metal binding site [ion binding]; metal-binding site 441620006166 active site 441620006167 I-site; other site 441620006168 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 441620006169 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 441620006170 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 441620006171 putative catalytic residue [active] 441620006172 argininosuccinate synthase; Provisional; Region: PRK13820 441620006173 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 441620006174 ANP binding site [chemical binding]; other site 441620006175 Substrate Binding Site II [chemical binding]; other site 441620006176 Substrate Binding Site I [chemical binding]; other site 441620006177 phosphoglycolate phosphatase; Provisional; Region: PRK13222 441620006178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441620006179 motif II; other site 441620006180 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 441620006181 tetramer (dimer of dimers) interface [polypeptide binding]; other site 441620006182 active site 441620006183 dimer interface [polypeptide binding]; other site 441620006184 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 441620006185 O-Antigen ligase; Region: Wzy_C; pfam04932 441620006186 glutathione reductase; Validated; Region: PRK06116 441620006187 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441620006188 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 441620006189 hypothetical protein; Provisional; Region: PRK10316 441620006190 YfdX protein; Region: YfdX; pfam10938 441620006191 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 441620006192 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 441620006193 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 441620006194 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 441620006195 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441620006196 FeS/SAM binding site; other site 441620006197 Domain of unknown function (DUF4130; Region: DUF4130; pfam13566 441620006198 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 441620006199 Fe-S cluster binding site [ion binding]; other site 441620006200 active site 441620006201 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 441620006202 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 441620006203 NAD binding site [chemical binding]; other site 441620006204 catalytic Zn binding site [ion binding]; other site 441620006205 structural Zn binding site [ion binding]; other site 441620006206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 441620006207 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 441620006208 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441620006209 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441620006210 catalytic residue [active] 441620006211 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 441620006212 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 441620006213 putative C-terminal domain interface [polypeptide binding]; other site 441620006214 putative GSH binding site (G-site) [chemical binding]; other site 441620006215 putative dimer interface [polypeptide binding]; other site 441620006216 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 441620006217 dimer interface [polypeptide binding]; other site 441620006218 N-terminal domain interface [polypeptide binding]; other site 441620006219 substrate binding pocket (H-site) [chemical binding]; other site 441620006220 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 441620006221 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 441620006222 putative FMN binding site [chemical binding]; other site 441620006223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441620006224 DNA-binding site [nucleotide binding]; DNA binding site 441620006225 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 441620006226 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441620006227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620006228 homodimer interface [polypeptide binding]; other site 441620006229 catalytic residue [active] 441620006230 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 441620006231 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 441620006232 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 441620006233 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 441620006234 active site 441620006235 dimer interface [polypeptide binding]; other site 441620006236 motif 1; other site 441620006237 motif 2; other site 441620006238 motif 3; other site 441620006239 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 441620006240 anticodon binding site; other site 441620006241 fructokinase; Reviewed; Region: PRK09557 441620006242 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 441620006243 nucleotide binding site [chemical binding]; other site 441620006244 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 441620006245 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 441620006246 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 441620006247 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441620006248 active site 441620006249 HIGH motif; other site 441620006250 nucleotide binding site [chemical binding]; other site 441620006251 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 441620006252 active site 441620006253 KMSKS motif; other site 441620006254 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 441620006255 tRNA binding surface [nucleotide binding]; other site 441620006256 anticodon binding site; other site 441620006257 lipoprotein signal peptidase; Provisional; Region: PRK14796 441620006258 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 441620006259 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 441620006260 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 441620006261 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 441620006262 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 441620006263 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 441620006264 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 441620006265 Zn binding site [ion binding]; other site 441620006266 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 441620006267 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 441620006268 Zn binding site [ion binding]; other site 441620006269 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 441620006270 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 441620006271 FAD binding pocket [chemical binding]; other site 441620006272 FAD binding motif [chemical binding]; other site 441620006273 phosphate binding motif [ion binding]; other site 441620006274 beta-alpha-beta structure motif; other site 441620006275 NAD binding pocket [chemical binding]; other site 441620006276 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 441620006277 AAA domain; Region: AAA_26; pfam13500 441620006278 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 441620006279 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620006280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620006281 active site 441620006282 phosphorylation site [posttranslational modification] 441620006283 intermolecular recognition site; other site 441620006284 dimerization interface [polypeptide binding]; other site 441620006285 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 441620006286 FOG: WD40 repeat [General function prediction only]; Region: COG2319 441620006287 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 441620006288 structural tetrad; other site 441620006289 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 441620006290 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 441620006291 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 441620006292 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 441620006293 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 441620006294 feedback inhibition sensing region; other site 441620006295 homohexameric interface [polypeptide binding]; other site 441620006296 nucleotide binding site [chemical binding]; other site 441620006297 N-acetyl-L-glutamate binding site [chemical binding]; other site 441620006298 Fic family protein [Function unknown]; Region: COG3177 441620006299 Fic/DOC family; Region: Fic; pfam02661 441620006300 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 441620006301 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 441620006302 MOSC domain; Region: MOSC; pfam03473 441620006303 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 441620006304 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 441620006305 MOSC domain; Region: MOSC; pfam03473 441620006306 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 441620006307 Clp amino terminal domain; Region: Clp_N; pfam02861 441620006308 Clp amino terminal domain; Region: Clp_N; pfam02861 441620006309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620006310 Walker A motif; other site 441620006311 ATP binding site [chemical binding]; other site 441620006312 Walker B motif; other site 441620006313 arginine finger; other site 441620006314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620006315 Walker A motif; other site 441620006316 ATP binding site [chemical binding]; other site 441620006317 Walker B motif; other site 441620006318 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 441620006319 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 441620006320 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 441620006321 active site 441620006322 metal binding site [ion binding]; metal-binding site 441620006323 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 441620006324 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 441620006325 Protein of unknown function (DUF423); Region: DUF423; cl01008 441620006326 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 441620006327 G1 box; other site 441620006328 GTP/Mg2+ binding site [chemical binding]; other site 441620006329 Switch I region; other site 441620006330 G2 box; other site 441620006331 G3 box; other site 441620006332 Switch II region; other site 441620006333 G4 box; other site 441620006334 G5 box; other site 441620006335 membrane protein insertase; Provisional; Region: PRK01318 441620006336 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 441620006337 Ribonuclease P; Region: Ribonuclease_P; pfam00825 441620006338 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 441620006339 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 441620006340 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 441620006341 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 441620006342 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441620006343 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 441620006344 Walker A/P-loop; other site 441620006345 ATP binding site [chemical binding]; other site 441620006346 Q-loop/lid; other site 441620006347 ABC transporter signature motif; other site 441620006348 Walker B; other site 441620006349 D-loop; other site 441620006350 H-loop/switch region; other site 441620006351 D-cysteine desulfhydrase; Validated; Region: PRK03910 441620006352 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 441620006353 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441620006354 catalytic residue [active] 441620006355 hypothetical protein; Validated; Region: PRK09039 441620006356 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 441620006357 ligand binding site [chemical binding]; other site 441620006358 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 441620006359 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 441620006360 putative active site [active] 441620006361 metal binding site [ion binding]; metal-binding site 441620006362 homodimer binding site [polypeptide binding]; other site 441620006363 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 441620006364 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 441620006365 Cell division protein ZapA; Region: ZapA; pfam05164 441620006366 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 441620006367 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 441620006368 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 441620006369 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 441620006370 Phosphoglycerate kinase; Region: PGK; pfam00162 441620006371 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 441620006372 substrate binding site [chemical binding]; other site 441620006373 hinge regions; other site 441620006374 ADP binding site [chemical binding]; other site 441620006375 catalytic site [active] 441620006376 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 441620006377 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 441620006378 intersubunit interface [polypeptide binding]; other site 441620006379 active site 441620006380 zinc binding site [ion binding]; other site 441620006381 Na+ binding site [ion binding]; other site 441620006382 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 441620006383 active site 441620006384 pyrophosphate binding site [ion binding]; other site 441620006385 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 441620006386 Sel1-like repeats; Region: SEL1; smart00671 441620006387 Sel1-like repeats; Region: SEL1; smart00671 441620006388 amino acid transporter; Region: 2A0306; TIGR00909 441620006389 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 441620006390 Uncharacterized conserved protein [Function unknown]; Region: COG0062 441620006391 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 441620006392 putative substrate binding site [chemical binding]; other site 441620006393 putative ATP binding site [chemical binding]; other site 441620006394 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 441620006395 Nitrogen regulatory protein P-II; Region: P-II; smart00938 441620006396 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 441620006397 glutaminase; Provisional; Region: PRK00971 441620006398 glutamine synthetase; Region: PLN02284 441620006399 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 441620006400 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 441620006401 glutamine synthetase; Provisional; Region: glnA; PRK09469 441620006402 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 441620006403 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 441620006404 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 441620006405 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620006406 metal binding site [ion binding]; metal-binding site 441620006407 active site 441620006408 I-site; other site 441620006409 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 441620006410 Predicted flavoprotein [General function prediction only]; Region: COG0431 441620006411 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 441620006412 ribonuclease R; Region: RNase_R; TIGR02063 441620006413 RNB domain; Region: RNB; pfam00773 441620006414 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 441620006415 RNA binding site [nucleotide binding]; other site 441620006416 Protein of unknown function (DUF983); Region: DUF983; cl02211 441620006417 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620006418 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 441620006419 putative active site [active] 441620006420 heme pocket [chemical binding]; other site 441620006421 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620006422 putative active site [active] 441620006423 heme pocket [chemical binding]; other site 441620006424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620006425 PAS domain; Region: PAS_9; pfam13426 441620006426 putative active site [active] 441620006427 heme pocket [chemical binding]; other site 441620006428 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620006429 dimer interface [polypeptide binding]; other site 441620006430 putative CheW interface [polypeptide binding]; other site 441620006431 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 441620006432 putative NAD(P) binding site [chemical binding]; other site 441620006433 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441620006434 epoxyqueuosine reductase; Region: TIGR00276 441620006435 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 441620006436 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 441620006437 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 441620006438 C-terminal domain interface [polypeptide binding]; other site 441620006439 GSH binding site (G-site) [chemical binding]; other site 441620006440 dimer interface [polypeptide binding]; other site 441620006441 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 441620006442 N-terminal domain interface [polypeptide binding]; other site 441620006443 dimer interface [polypeptide binding]; other site 441620006444 substrate binding pocket (H-site) [chemical binding]; other site 441620006445 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 441620006446 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 441620006447 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 441620006448 heterodimer interface [polypeptide binding]; other site 441620006449 substrate interaction site [chemical binding]; other site 441620006450 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 441620006451 Methyltransferase domain; Region: Methyltransf_24; pfam13578 441620006452 Protein of unknown function (DUF563); Region: DUF563; pfam04577 441620006453 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 441620006454 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 441620006455 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 441620006456 NAD binding site [chemical binding]; other site 441620006457 substrate binding site [chemical binding]; other site 441620006458 homodimer interface [polypeptide binding]; other site 441620006459 active site 441620006460 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 441620006461 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 441620006462 NADP binding site [chemical binding]; other site 441620006463 active site 441620006464 putative substrate binding site [chemical binding]; other site 441620006465 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 441620006466 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 441620006467 substrate binding site; other site 441620006468 tetramer interface; other site 441620006469 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441620006470 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620006471 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898 441620006472 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 441620006473 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 441620006474 active site 441620006475 putative substrate binding region [chemical binding]; other site 441620006476 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620006477 GAF domain; Region: GAF; cl17456 441620006478 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441620006479 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620006480 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 441620006481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620006482 S-adenosylmethionine binding site [chemical binding]; other site 441620006483 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 441620006484 active site 441620006485 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 441620006486 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 441620006487 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441620006488 FeS/SAM binding site; other site 441620006489 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441620006490 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441620006491 SapC; Region: SapC; pfam07277 441620006492 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 441620006493 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 441620006494 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 441620006495 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 441620006496 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 441620006497 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 441620006498 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 441620006499 Multicopper oxidase; Region: Cu-oxidase; pfam00394 441620006500 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 441620006501 trigger factor; Provisional; Region: tig; PRK01490 441620006502 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 441620006503 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 441620006504 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 441620006505 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 441620006506 oligomer interface [polypeptide binding]; other site 441620006507 active site residues [active] 441620006508 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 441620006509 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 441620006510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620006511 Walker A motif; other site 441620006512 ATP binding site [chemical binding]; other site 441620006513 Walker B motif; other site 441620006514 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 441620006515 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 441620006516 Found in ATP-dependent protease La (LON); Region: LON; smart00464 441620006517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620006518 Walker A motif; other site 441620006519 ATP binding site [chemical binding]; other site 441620006520 Walker B motif; other site 441620006521 arginine finger; other site 441620006522 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 441620006523 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 441620006524 putative ADP-binding pocket [chemical binding]; other site 441620006525 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620006526 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 441620006527 Methyltransferase domain; Region: Methyltransf_25; pfam13649 441620006528 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 441620006529 Methyltransferase domain; Region: Methyltransf_31; pfam13847 441620006530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620006531 S-adenosylmethionine binding site [chemical binding]; other site 441620006532 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 441620006533 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 441620006534 OPT oligopeptide transporter protein; Region: OPT; cl14607 441620006535 putative oligopeptide transporter, OPT family; Region: TIGR00733 441620006536 ABC-2 type transporter; Region: ABC2_membrane; cl17235 441620006537 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 441620006538 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 441620006539 catalytic residues [active] 441620006540 catalytic nucleophile [active] 441620006541 Recombinase; Region: Recombinase; pfam07508 441620006542 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 441620006543 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 441620006544 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 441620006545 Transposase, Mutator family; Region: Transposase_mut; pfam00872 441620006546 MULE transposase domain; Region: MULE; pfam10551 441620006547 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 441620006548 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441620006549 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441620006550 active site 441620006551 DNA binding site [nucleotide binding] 441620006552 Int/Topo IB signature motif; other site 441620006553 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 441620006554 5'-3' exonuclease; Region: 53EXOc; smart00475 441620006555 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 441620006556 active site 441620006557 metal binding site 1 [ion binding]; metal-binding site 441620006558 putative 5' ssDNA interaction site; other site 441620006559 metal binding site 3; metal-binding site 441620006560 metal binding site 2 [ion binding]; metal-binding site 441620006561 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 441620006562 putative DNA binding site [nucleotide binding]; other site 441620006563 putative metal binding site [ion binding]; other site 441620006564 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 441620006565 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 441620006566 active site 441620006567 catalytic site [active] 441620006568 substrate binding site [chemical binding]; other site 441620006569 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 441620006570 active site 441620006571 DNA binding site [nucleotide binding] 441620006572 catalytic site [active] 441620006573 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 441620006574 Active_site [active] 441620006575 GTP-binding protein YchF; Reviewed; Region: PRK09601 441620006576 YchF GTPase; Region: YchF; cd01900 441620006577 G1 box; other site 441620006578 GTP/Mg2+ binding site [chemical binding]; other site 441620006579 Switch I region; other site 441620006580 G2 box; other site 441620006581 Switch II region; other site 441620006582 G3 box; other site 441620006583 G4 box; other site 441620006584 G5 box; other site 441620006585 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 441620006586 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 441620006587 putative active site [active] 441620006588 catalytic residue [active] 441620006589 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 441620006590 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 441620006591 5S rRNA interface [nucleotide binding]; other site 441620006592 CTC domain interface [polypeptide binding]; other site 441620006593 L16 interface [polypeptide binding]; other site 441620006594 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 441620006595 Flp/Fap pilin component; Region: Flp_Fap; cl01585 441620006596 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 441620006597 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 441620006598 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 441620006599 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 441620006600 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 441620006601 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 441620006602 Type IV pili component [Cell motility and secretion]; Region: COG5461 441620006603 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 441620006604 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 441620006605 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 441620006606 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 441620006607 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 441620006608 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 441620006609 ATP binding site [chemical binding]; other site 441620006610 Walker A motif; other site 441620006611 hexamer interface [polypeptide binding]; other site 441620006612 Walker B motif; other site 441620006613 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 441620006614 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 441620006615 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 441620006616 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 441620006617 putative active site [active] 441620006618 putative catalytic site [active] 441620006619 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 441620006620 putative active site [active] 441620006621 putative catalytic site [active] 441620006622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620006623 metabolite-proton symporter; Region: 2A0106; TIGR00883 441620006624 putative substrate translocation pore; other site 441620006625 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 441620006626 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 441620006627 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 441620006628 CoenzymeA binding site [chemical binding]; other site 441620006629 subunit interaction site [polypeptide binding]; other site 441620006630 PHB binding site; other site 441620006631 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441620006632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620006633 putative substrate translocation pore; other site 441620006634 UL45 protein; Region: Herpes_UL45; pfam05473 441620006635 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620006636 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620006637 metal binding site [ion binding]; metal-binding site 441620006638 active site 441620006639 I-site; other site 441620006640 BA14K-like protein; Region: BA14K; pfam07886 441620006641 CsbD-like; Region: CsbD; pfam05532 441620006642 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 441620006643 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 441620006644 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 441620006645 catalytic site [active] 441620006646 putative active site [active] 441620006647 putative substrate binding site [chemical binding]; other site 441620006648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 441620006649 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 441620006650 OstA-like protein; Region: OstA; pfam03968 441620006651 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 441620006652 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 441620006653 Walker A/P-loop; other site 441620006654 ATP binding site [chemical binding]; other site 441620006655 Q-loop/lid; other site 441620006656 ABC transporter signature motif; other site 441620006657 Walker B; other site 441620006658 D-loop; other site 441620006659 H-loop/switch region; other site 441620006660 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 441620006661 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 441620006662 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 441620006663 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 441620006664 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 441620006665 30S subunit binding site; other site 441620006666 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 441620006667 active site 441620006668 phosphorylation site [posttranslational modification] 441620006669 magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407 441620006670 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 441620006671 catalytic core [active] 441620006672 dihydrodipicolinate reductase; Provisional; Region: PRK00048 441620006673 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 441620006674 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 441620006675 MarC family integral membrane protein; Region: MarC; cl00919 441620006676 Methyltransferase domain; Region: Methyltransf_23; pfam13489 441620006677 Methyltransferase domain; Region: Methyltransf_11; pfam08241 441620006678 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 441620006679 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 441620006680 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441620006681 active site 441620006682 DNA binding site [nucleotide binding] 441620006683 Int/Topo IB signature motif; other site 441620006684 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620006685 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620006686 metal binding site [ion binding]; metal-binding site 441620006687 active site 441620006688 I-site; other site 441620006689 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 441620006690 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 441620006691 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 441620006692 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 441620006693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620006694 dimer interface [polypeptide binding]; other site 441620006695 conserved gate region; other site 441620006696 ABC-ATPase subunit interface; other site 441620006697 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 441620006698 hypothetical protein; Provisional; Region: PRK08912 441620006699 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441620006700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620006701 homodimer interface [polypeptide binding]; other site 441620006702 catalytic residue [active] 441620006703 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441620006704 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620006705 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620006706 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 441620006707 Protein export membrane protein; Region: SecD_SecF; cl14618 441620006708 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 441620006709 Protein export membrane protein; Region: SecD_SecF; cl14618 441620006710 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 441620006711 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 441620006712 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 441620006713 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 441620006714 tartrate dehydrogenase; Region: TTC; TIGR02089 441620006715 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 441620006716 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 441620006717 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 441620006718 PYR/PP interface [polypeptide binding]; other site 441620006719 dimer interface [polypeptide binding]; other site 441620006720 TPP binding site [chemical binding]; other site 441620006721 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 441620006722 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 441620006723 TPP-binding site [chemical binding]; other site 441620006724 dimer interface [polypeptide binding]; other site 441620006725 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 441620006726 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 441620006727 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 441620006728 substrate binding pocket [chemical binding]; other site 441620006729 chain length determination region; other site 441620006730 substrate-Mg2+ binding site; other site 441620006731 catalytic residues [active] 441620006732 aspartate-rich region 1; other site 441620006733 active site lid residues [active] 441620006734 aspartate-rich region 2; other site 441620006735 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 441620006736 Transglycosylase; Region: Transgly; cl17702 441620006737 photolyase PhrII; Region: phr2; TIGR00591 441620006738 DNA photolyase; Region: DNA_photolyase; pfam00875 441620006739 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 441620006740 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 441620006741 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 441620006742 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 441620006743 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 441620006744 dimerization interface [polypeptide binding]; other site 441620006745 ligand binding site [chemical binding]; other site 441620006746 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 441620006747 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 441620006748 Sulfatase; Region: Sulfatase; cl17466 441620006749 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 441620006750 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 441620006751 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 441620006752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620006753 NAD(P) binding site [chemical binding]; other site 441620006754 active site 441620006755 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 441620006756 active site 441620006757 cosubstrate binding site; other site 441620006758 substrate binding site [chemical binding]; other site 441620006759 catalytic site [active] 441620006760 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 441620006761 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 441620006762 homodimer interface [polypeptide binding]; other site 441620006763 substrate-cofactor binding pocket; other site 441620006764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620006765 catalytic residue [active] 441620006766 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 441620006767 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 441620006768 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 441620006769 [2Fe-2S] cluster binding site [ion binding]; other site 441620006770 cytochrome b; Provisional; Region: CYTB; MTH00191 441620006771 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 441620006772 Qi binding site; other site 441620006773 intrachain domain interface; other site 441620006774 interchain domain interface [polypeptide binding]; other site 441620006775 heme bH binding site [chemical binding]; other site 441620006776 heme bL binding site [chemical binding]; other site 441620006777 Qo binding site; other site 441620006778 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 441620006779 interchain domain interface [polypeptide binding]; other site 441620006780 intrachain domain interface; other site 441620006781 Qi binding site; other site 441620006782 Qo binding site; other site 441620006783 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 441620006784 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 441620006785 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 441620006786 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 441620006787 Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396 441620006788 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 441620006789 active site 441620006790 metal binding site [ion binding]; metal-binding site 441620006791 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 441620006792 putative active site pocket [active] 441620006793 4-fold oligomerization interface [polypeptide binding]; other site 441620006794 metal binding residues [ion binding]; metal-binding site 441620006795 3-fold/trimer interface [polypeptide binding]; other site 441620006796 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 441620006797 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 441620006798 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 441620006799 putative active site [active] 441620006800 oxyanion strand; other site 441620006801 catalytic triad [active] 441620006802 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 441620006803 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 441620006804 catalytic residues [active] 441620006805 Domain of unknown function DUF29; Region: DUF29; pfam01724 441620006806 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 441620006807 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 441620006808 substrate binding site [chemical binding]; other site 441620006809 glutamase interaction surface [polypeptide binding]; other site 441620006810 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 441620006811 metal binding site [ion binding]; metal-binding site 441620006812 pantothenate kinase; Provisional; Region: PRK05439 441620006813 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 441620006814 ATP-binding site [chemical binding]; other site 441620006815 CoA-binding site [chemical binding]; other site 441620006816 Mg2+-binding site [ion binding]; other site 441620006817 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441620006818 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441620006819 catalytic residue [active] 441620006820 Response regulator receiver domain; Region: Response_reg; pfam00072 441620006821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620006822 active site 441620006823 phosphorylation site [posttranslational modification] 441620006824 intermolecular recognition site; other site 441620006825 dimerization interface [polypeptide binding]; other site 441620006826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 441620006827 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441620006828 phasin; Region: phasin_2; TIGR01985 441620006829 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620006830 putative active site [active] 441620006831 heme pocket [chemical binding]; other site 441620006832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620006833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620006834 dimer interface [polypeptide binding]; other site 441620006835 phosphorylation site [posttranslational modification] 441620006836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620006837 ATP binding site [chemical binding]; other site 441620006838 Mg2+ binding site [ion binding]; other site 441620006839 G-X-G motif; other site 441620006840 acetyl-CoA synthetase; Provisional; Region: PRK00174 441620006841 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 441620006842 active site 441620006843 CoA binding site [chemical binding]; other site 441620006844 acyl-activating enzyme (AAE) consensus motif; other site 441620006845 AMP binding site [chemical binding]; other site 441620006846 acetate binding site [chemical binding]; other site 441620006847 Protein of unknown function, DUF485; Region: DUF485; pfam04341 441620006848 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 441620006849 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 441620006850 Na binding site [ion binding]; other site 441620006851 metabolite-proton symporter; Region: 2A0106; TIGR00883 441620006852 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 441620006853 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 441620006854 purine monophosphate binding site [chemical binding]; other site 441620006855 dimer interface [polypeptide binding]; other site 441620006856 putative catalytic residues [active] 441620006857 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 441620006858 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 441620006859 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 441620006860 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 441620006861 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 441620006862 active site residue [active] 441620006863 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 441620006864 active site residue [active] 441620006865 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 441620006866 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 441620006867 DEAD-like helicases superfamily; Region: DEXDc; smart00487 441620006868 ATP binding site [chemical binding]; other site 441620006869 Mg++ binding site [ion binding]; other site 441620006870 motif III; other site 441620006871 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441620006872 nucleotide binding region [chemical binding]; other site 441620006873 ATP-binding site [chemical binding]; other site 441620006874 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 441620006875 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 441620006876 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 441620006877 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 441620006878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620006879 Mg2+ binding site [ion binding]; other site 441620006880 G-X-G motif; other site 441620006881 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 441620006882 anchoring element; other site 441620006883 dimer interface [polypeptide binding]; other site 441620006884 ATP binding site [chemical binding]; other site 441620006885 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 441620006886 active site 441620006887 putative metal-binding site [ion binding]; other site 441620006888 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 441620006889 FRG domain; Region: FRG; pfam08867 441620006890 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 441620006891 ATP binding site [chemical binding]; other site 441620006892 substrate binding site [chemical binding]; other site 441620006893 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 441620006894 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 441620006895 ATP binding site [chemical binding]; other site 441620006896 substrate binding site [chemical binding]; other site 441620006897 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 441620006898 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 441620006899 helix-hairpin-helix signature motif; other site 441620006900 active site 441620006901 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620006902 sequence-specific DNA binding site [nucleotide binding]; other site 441620006903 salt bridge; other site 441620006904 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 441620006905 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 441620006906 CHAT domain; Region: CHAT; cl17868 441620006907 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 441620006908 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 441620006909 putative homodimer interface [polypeptide binding]; other site 441620006910 putative homotetramer interface [polypeptide binding]; other site 441620006911 putative allosteric switch controlling residues; other site 441620006912 putative metal binding site [ion binding]; other site 441620006913 putative homodimer-homodimer interface [polypeptide binding]; other site 441620006914 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 441620006915 dimerization interface [polypeptide binding]; other site 441620006916 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 441620006917 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 441620006918 DNA binding residues [nucleotide binding] 441620006919 dimer interface [polypeptide binding]; other site 441620006920 copper binding site [ion binding]; other site 441620006921 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441620006922 metal-binding site [ion binding] 441620006923 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441620006924 metal-binding site [ion binding] 441620006925 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 441620006926 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441620006927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441620006928 motif II; other site 441620006929 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441620006930 metal-binding site [ion binding] 441620006931 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 441620006932 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 441620006933 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441620006934 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 441620006935 Walker A/P-loop; other site 441620006936 ATP binding site [chemical binding]; other site 441620006937 Q-loop/lid; other site 441620006938 ABC transporter signature motif; other site 441620006939 Walker B; other site 441620006940 D-loop; other site 441620006941 H-loop/switch region; other site 441620006942 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 441620006943 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620006944 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620006945 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 441620006946 NADH dehydrogenase; Region: NADHdh; cl00469 441620006947 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 441620006948 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 441620006949 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 441620006950 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 441620006951 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 441620006952 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 441620006953 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 441620006954 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 441620006955 active site 441620006956 NTP binding site [chemical binding]; other site 441620006957 metal binding triad [ion binding]; metal-binding site 441620006958 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 441620006959 YHS domain; Region: YHS; pfam04945 441620006960 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 441620006961 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441620006962 Soluble P-type ATPase [General function prediction only]; Region: COG4087 441620006963 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 441620006964 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441620006965 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441620006966 catalytic residue [active] 441620006967 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 441620006968 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 441620006969 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 441620006970 Probable transposase; Region: OrfB_IS605; pfam01385 441620006971 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 441620006972 active site 441620006973 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 441620006974 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 441620006975 Zn binding sites [ion binding]; other site 441620006976 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 441620006977 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 441620006978 Zn binding sites [ion binding]; other site 441620006979 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 441620006980 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 441620006981 Zn binding sites [ion binding]; other site 441620006982 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 441620006983 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 441620006984 Zn binding sites [ion binding]; other site 441620006985 Protein of unknown function, DUF; Region: DUF411; cl01142 441620006986 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 441620006987 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 441620006988 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620006989 YtkA-like; Region: YtkA; pfam13115 441620006990 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 441620006991 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 441620006992 Probable transposase; Region: OrfB_IS605; pfam01385 441620006993 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 441620006994 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 441620006995 RNA polymerase sigma factor; Provisional; Region: PRK12539 441620006996 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441620006997 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 441620006998 DNA binding residues [nucleotide binding] 441620006999 Domain of unknown function (DUF305); Region: DUF305; cl17794 441620007000 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 441620007001 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 441620007002 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 441620007003 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 441620007004 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 441620007005 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 441620007006 Cytochrome c; Region: Cytochrom_C; cl11414 441620007007 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 441620007008 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 441620007009 putative ADP-binding pocket [chemical binding]; other site 441620007010 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 441620007011 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 441620007012 ligand binding site [chemical binding]; other site 441620007013 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 441620007014 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 441620007015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620007016 AAA domain; Region: AAA_23; pfam13476 441620007017 Walker A/P-loop; other site 441620007018 ATP binding site [chemical binding]; other site 441620007019 AAA domain; Region: AAA_21; pfam13304 441620007020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620007021 ABC transporter signature motif; other site 441620007022 Walker B; other site 441620007023 D-loop; other site 441620007024 H-loop/switch region; other site 441620007025 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 441620007026 active site 441620007027 catalytic site [active] 441620007028 substrate binding site [chemical binding]; other site 441620007029 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 441620007030 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 441620007031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620007032 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 441620007033 Walker A motif; other site 441620007034 ATP binding site [chemical binding]; other site 441620007035 Walker B motif; other site 441620007036 arginine finger; other site 441620007037 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 441620007038 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 441620007039 putative active site [active] 441620007040 putative metal binding site [ion binding]; other site 441620007041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620007042 non-specific DNA binding site [nucleotide binding]; other site 441620007043 salt bridge; other site 441620007044 sequence-specific DNA binding site [nucleotide binding]; other site 441620007045 Cache domain; Region: Cache_1; pfam02743 441620007046 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620007047 metal binding site [ion binding]; metal-binding site 441620007048 active site 441620007049 I-site; other site 441620007050 Predicted membrane protein [Function unknown]; Region: COG4763 441620007051 Acyltransferase family; Region: Acyl_transf_3; pfam01757 441620007052 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 441620007053 Integrase core domain; Region: rve; pfam00665 441620007054 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 441620007055 AAA domain; Region: AAA_22; pfam13401 441620007056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620007057 Walker A motif; other site 441620007058 ATP binding site [chemical binding]; other site 441620007059 Walker B motif; other site 441620007060 arginine finger; other site 441620007061 TniQ; Region: TniQ; pfam06527 441620007062 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 441620007063 TniQ; Region: TniQ; pfam06527 441620007064 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 441620007065 RNA polymerase sigma factor; Provisional; Region: PRK12547 441620007066 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441620007067 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441620007068 DNA binding residues [nucleotide binding] 441620007069 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 441620007070 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 441620007071 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 441620007072 aspartate aminotransferase; Provisional; Region: PRK05764 441620007073 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441620007074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620007075 homodimer interface [polypeptide binding]; other site 441620007076 catalytic residue [active] 441620007077 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620007078 HAMP domain; Region: HAMP; pfam00672 441620007079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620007080 dimer interface [polypeptide binding]; other site 441620007081 phosphorylation site [posttranslational modification] 441620007082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620007083 ATP binding site [chemical binding]; other site 441620007084 Mg2+ binding site [ion binding]; other site 441620007085 G-X-G motif; other site 441620007086 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441620007087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620007088 active site 441620007089 phosphorylation site [posttranslational modification] 441620007090 intermolecular recognition site; other site 441620007091 dimerization interface [polypeptide binding]; other site 441620007092 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620007093 DNA binding site [nucleotide binding] 441620007094 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441620007095 MarR family; Region: MarR_2; pfam12802 441620007096 branched-chain amino acid aminotransferase; Validated; Region: PRK07544 441620007097 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 441620007098 homodimer interface [polypeptide binding]; other site 441620007099 substrate-cofactor binding pocket; other site 441620007100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620007101 catalytic residue [active] 441620007102 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 441620007103 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 441620007104 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 441620007105 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 441620007106 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441620007107 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 441620007108 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 441620007109 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 441620007110 TrkA-N domain; Region: TrkA_N; pfam02254 441620007111 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 441620007112 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 441620007113 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 441620007114 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 441620007115 putative active site [active] 441620007116 putative substrate binding site [chemical binding]; other site 441620007117 ATP binding site [chemical binding]; other site 441620007118 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 441620007119 catalytic triad [active] 441620007120 dimer interface [polypeptide binding]; other site 441620007121 hypothetical protein; Validated; Region: PRK00228 441620007122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 441620007123 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 441620007124 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 441620007125 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 441620007126 motif 1; other site 441620007127 active site 441620007128 motif 2; other site 441620007129 motif 3; other site 441620007130 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 441620007131 Predicted transcriptional regulator [Transcription]; Region: COG2378 441620007132 HTH domain; Region: HTH_11; pfam08279 441620007133 WYL domain; Region: WYL; pfam13280 441620007134 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 441620007135 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 441620007136 putative C-terminal domain interface [polypeptide binding]; other site 441620007137 putative GSH binding site (G-site) [chemical binding]; other site 441620007138 putative dimer interface [polypeptide binding]; other site 441620007139 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 441620007140 dimer interface [polypeptide binding]; other site 441620007141 N-terminal domain interface [polypeptide binding]; other site 441620007142 putative substrate binding pocket (H-site) [chemical binding]; other site 441620007143 recombinase A; Provisional; Region: recA; PRK09354 441620007144 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 441620007145 hexamer interface [polypeptide binding]; other site 441620007146 Walker A motif; other site 441620007147 ATP binding site [chemical binding]; other site 441620007148 Walker B motif; other site 441620007149 PAS domain; Region: PAS_9; pfam13426 441620007150 PAS domain; Region: PAS_9; pfam13426 441620007151 PAS domain; Region: PAS_8; pfam13188 441620007152 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 441620007153 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620007154 dimer interface [polypeptide binding]; other site 441620007155 phosphorylation site [posttranslational modification] 441620007156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620007157 ATP binding site [chemical binding]; other site 441620007158 Mg2+ binding site [ion binding]; other site 441620007159 G-X-G motif; other site 441620007160 Response regulator receiver domain; Region: Response_reg; pfam00072 441620007161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620007162 active site 441620007163 phosphorylation site [posttranslational modification] 441620007164 intermolecular recognition site; other site 441620007165 dimerization interface [polypeptide binding]; other site 441620007166 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 441620007167 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 441620007168 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 441620007169 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 441620007170 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 441620007171 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 441620007172 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 441620007173 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441620007174 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 441620007175 Predicted dehydrogenase [General function prediction only]; Region: COG0579 441620007176 hydroxyglutarate oxidase; Provisional; Region: PRK11728 441620007177 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 441620007178 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 441620007179 heme exporter protein CcmC; Region: ccmC; TIGR01191 441620007180 Heme exporter protein D (CcmD); Region: CcmD; pfam04995 441620007181 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 441620007182 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 441620007183 catalytic residues [active] 441620007184 central insert; other site 441620007185 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 441620007186 Cysteine-rich domain; Region: CCG; pfam02754 441620007187 Cysteine-rich domain; Region: CCG; pfam02754 441620007188 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 441620007189 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 441620007190 4Fe-4S binding domain; Region: Fer4; pfam00037 441620007191 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 441620007192 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 441620007193 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 441620007194 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 441620007195 23S rRNA interface [nucleotide binding]; other site 441620007196 L3 interface [polypeptide binding]; other site 441620007197 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 441620007198 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 441620007199 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 441620007200 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 441620007201 active site 441620007202 catalytic residues [active] 441620007203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620007204 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 441620007205 Walker A/P-loop; other site 441620007206 ATP binding site [chemical binding]; other site 441620007207 Q-loop/lid; other site 441620007208 ABC transporter signature motif; other site 441620007209 Walker B; other site 441620007210 D-loop; other site 441620007211 H-loop/switch region; other site 441620007212 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441620007213 TIGR02594 family protein; Region: TIGR02594 441620007214 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 441620007215 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 441620007216 active site 441620007217 metal binding site [ion binding]; metal-binding site 441620007218 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 441620007219 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 441620007220 tape measure domain; Region: tape_meas_nterm; TIGR02675 441620007221 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 441620007222 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 441620007223 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 441620007224 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 441620007225 Phage capsid family; Region: Phage_capsid; pfam05065 441620007226 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 441620007227 Phage-related protein [Function unknown]; Region: COG4695; cl01923 441620007228 Phage portal protein; Region: Phage_portal; pfam04860 441620007229 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 441620007230 HNH endonuclease; Region: HNH; pfam01844 441620007231 active site 441620007232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620007233 Walker A motif; other site 441620007234 ATP binding site [chemical binding]; other site 441620007235 Walker B motif; other site 441620007236 arginine finger; other site 441620007237 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 441620007238 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 441620007239 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 441620007240 beta-clamp/clamp loader binding surface; other site 441620007241 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 441620007242 non-specific DNA binding site [nucleotide binding]; other site 441620007243 salt bridge; other site 441620007244 sequence-specific DNA binding site [nucleotide binding]; other site 441620007245 DNA primase, catalytic core; Region: dnaG; TIGR01391 441620007246 CHC2 zinc finger; Region: zf-CHC2; pfam01807 441620007247 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 441620007248 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 441620007249 active site 441620007250 metal binding site [ion binding]; metal-binding site 441620007251 interdomain interaction site; other site 441620007252 replicative DNA helicase; Region: DnaB; TIGR00665 441620007253 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 441620007254 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441620007255 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441620007256 Walker A motif; other site 441620007257 Walker A motif; other site 441620007258 ATP binding site [chemical binding]; other site 441620007259 Walker B motif; other site 441620007260 MT-A70; Region: MT-A70; cl01947 441620007261 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 441620007262 active site 441620007263 putative DNA-binding cleft [nucleotide binding]; other site 441620007264 dimer interface [polypeptide binding]; other site 441620007265 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 441620007266 Ligand Binding Site [chemical binding]; other site 441620007267 exonuclease VIII; Reviewed; Region: PRK09709 441620007268 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 441620007269 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 441620007270 active site 441620007271 catalytic site [active] 441620007272 substrate binding site [chemical binding]; other site 441620007273 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 441620007274 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441620007275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620007276 non-specific DNA binding site [nucleotide binding]; other site 441620007277 salt bridge; other site 441620007278 sequence-specific DNA binding site [nucleotide binding]; other site 441620007279 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620007280 non-specific DNA binding site [nucleotide binding]; other site 441620007281 salt bridge; other site 441620007282 sequence-specific DNA binding site [nucleotide binding]; other site 441620007283 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 441620007284 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 441620007285 cofactor binding site; other site 441620007286 DNA binding site [nucleotide binding] 441620007287 substrate interaction site [chemical binding]; other site 441620007288 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 441620007289 Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505 441620007290 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 441620007291 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441620007292 active site 441620007293 DNA binding site [nucleotide binding] 441620007294 Int/Topo IB signature motif; other site 441620007295 Domain of unknown function (DUF329); Region: DUF329; pfam03884 441620007296 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 441620007297 active site 441620007298 dimer interface [polypeptide binding]; other site 441620007299 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 441620007300 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620007301 N-terminal plug; other site 441620007302 ligand-binding site [chemical binding]; other site 441620007303 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 441620007304 heme exporter protein CcmB; Region: ccmB; TIGR01190 441620007305 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 441620007306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620007307 Walker A/P-loop; other site 441620007308 ATP binding site [chemical binding]; other site 441620007309 Q-loop/lid; other site 441620007310 ABC transporter signature motif; other site 441620007311 Walker B; other site 441620007312 D-loop; other site 441620007313 H-loop/switch region; other site 441620007314 aconitate hydratase; Validated; Region: PRK09277 441620007315 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 441620007316 substrate binding site [chemical binding]; other site 441620007317 ligand binding site [chemical binding]; other site 441620007318 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 441620007319 substrate binding site [chemical binding]; other site 441620007320 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 441620007321 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 441620007322 maleylacetoacetate isomerase; Region: maiA; TIGR01262 441620007323 C-terminal domain interface [polypeptide binding]; other site 441620007324 GSH binding site (G-site) [chemical binding]; other site 441620007325 putative dimer interface [polypeptide binding]; other site 441620007326 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 441620007327 dimer interface [polypeptide binding]; other site 441620007328 N-terminal domain interface [polypeptide binding]; other site 441620007329 substrate binding pocket (H-site) [chemical binding]; other site 441620007330 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 441620007331 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441620007332 EthD domain; Region: EthD; cl17553 441620007333 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441620007334 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620007335 dimer interface [polypeptide binding]; other site 441620007336 putative CheW interface [polypeptide binding]; other site 441620007337 quinolinate synthetase; Provisional; Region: PRK09375 441620007338 L-aspartate oxidase; Provisional; Region: PRK06175 441620007339 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 441620007340 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 441620007341 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 441620007342 dimerization interface [polypeptide binding]; other site 441620007343 active site 441620007344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 441620007345 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441620007346 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939 441620007347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 441620007348 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 441620007349 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441620007350 FeS/SAM binding site; other site 441620007351 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 441620007352 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 441620007353 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 441620007354 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 441620007355 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 441620007356 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 441620007357 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 441620007358 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 441620007359 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 441620007360 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 441620007361 protein binding site [polypeptide binding]; other site 441620007362 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 441620007363 protein binding site [polypeptide binding]; other site 441620007364 HflC protein; Region: hflC; TIGR01932 441620007365 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 441620007366 HflK protein; Region: hflK; TIGR01933 441620007367 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 441620007368 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 441620007369 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 441620007370 folate binding site [chemical binding]; other site 441620007371 NADP+ binding site [chemical binding]; other site 441620007372 thymidylate synthase; Reviewed; Region: thyA; PRK01827 441620007373 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 441620007374 dimerization interface [polypeptide binding]; other site 441620007375 active site 441620007376 CAAX protease self-immunity; Region: Abi; pfam02517 441620007377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 441620007378 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 441620007379 Cytochrome P450; Region: p450; cl12078 441620007380 fumarate hydratase; Reviewed; Region: fumC; PRK00485 441620007381 Class II fumarases; Region: Fumarase_classII; cd01362 441620007382 active site 441620007383 tetramer interface [polypeptide binding]; other site 441620007384 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 441620007385 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 441620007386 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 441620007387 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 441620007388 cobalamin binding residues [chemical binding]; other site 441620007389 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 441620007390 putative BtuC binding residues; other site 441620007391 dimer interface [polypeptide binding]; other site 441620007392 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 441620007393 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 441620007394 pyridoxamine kinase; Validated; Region: PRK05756 441620007395 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 441620007396 dimer interface [polypeptide binding]; other site 441620007397 pyridoxal binding site [chemical binding]; other site 441620007398 ATP binding site [chemical binding]; other site 441620007399 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 441620007400 NUDIX domain; Region: NUDIX; pfam00293 441620007401 2-isopropylmalate synthase; Validated; Region: PRK00915 441620007402 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 441620007403 active site 441620007404 catalytic residues [active] 441620007405 metal binding site [ion binding]; metal-binding site 441620007406 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 441620007407 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 441620007408 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 441620007409 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 441620007410 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 441620007411 active site 441620007412 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441620007413 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441620007414 catalytic residue [active] 441620007415 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 441620007416 HD domain; Region: HD_3; cl17350 441620007417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620007418 Methyltransferase domain; Region: Methyltransf_23; pfam13489 441620007419 S-adenosylmethionine binding site [chemical binding]; other site 441620007420 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 441620007421 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 441620007422 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 441620007423 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 441620007424 YcaO-like family; Region: YcaO; pfam02624 441620007425 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 441620007426 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 441620007427 Metal-binding active site; metal-binding site 441620007428 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620007429 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 441620007430 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 441620007431 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 441620007432 ligand binding site [chemical binding]; other site 441620007433 active site 441620007434 Predicted integral membrane protein [Function unknown]; Region: COG0392 441620007435 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 441620007436 PAS domain; Region: PAS_8; pfam13188 441620007437 putative active site [active] 441620007438 heme pocket [chemical binding]; other site 441620007439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620007440 dimer interface [polypeptide binding]; other site 441620007441 phosphorylation site [posttranslational modification] 441620007442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620007443 ATP binding site [chemical binding]; other site 441620007444 Mg2+ binding site [ion binding]; other site 441620007445 G-X-G motif; other site 441620007446 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 441620007447 dimerization interface [polypeptide binding]; other site 441620007448 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441620007449 metal-binding site [ion binding] 441620007450 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 441620007451 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441620007452 metal-binding site [ion binding] 441620007453 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441620007454 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 441620007455 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 441620007456 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 441620007457 DNA binding residues [nucleotide binding] 441620007458 dimer interface [polypeptide binding]; other site 441620007459 copper binding site [ion binding]; other site 441620007460 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 441620007461 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 441620007462 metal binding site [ion binding]; metal-binding site 441620007463 putative dimer interface [polypeptide binding]; other site 441620007464 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441620007465 dimerization interface [polypeptide binding]; other site 441620007466 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620007467 dimer interface [polypeptide binding]; other site 441620007468 putative CheW interface [polypeptide binding]; other site 441620007469 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 441620007470 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 441620007471 RNA binding site [nucleotide binding]; other site 441620007472 active site 441620007473 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 441620007474 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 441620007475 translation initiation factor IF-2; Region: IF-2; TIGR00487 441620007476 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 441620007477 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 441620007478 G1 box; other site 441620007479 putative GEF interaction site [polypeptide binding]; other site 441620007480 GTP/Mg2+ binding site [chemical binding]; other site 441620007481 Switch I region; other site 441620007482 G2 box; other site 441620007483 G3 box; other site 441620007484 Switch II region; other site 441620007485 G4 box; other site 441620007486 G5 box; other site 441620007487 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 441620007488 Translation-initiation factor 2; Region: IF-2; pfam11987 441620007489 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 441620007490 hypothetical protein; Provisional; Region: PRK09190 441620007491 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 441620007492 putative RNA binding cleft [nucleotide binding]; other site 441620007493 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 441620007494 NusA N-terminal domain; Region: NusA_N; pfam08529 441620007495 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 441620007496 RNA binding site [nucleotide binding]; other site 441620007497 homodimer interface [polypeptide binding]; other site 441620007498 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 441620007499 G-X-X-G motif; other site 441620007500 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 441620007501 G-X-X-G motif; other site 441620007502 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 441620007503 ribosome maturation protein RimP; Reviewed; Region: PRK00092 441620007504 Sm and related proteins; Region: Sm_like; cl00259 441620007505 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 441620007506 putative oligomer interface [polypeptide binding]; other site 441620007507 putative RNA binding site [nucleotide binding]; other site 441620007508 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 441620007509 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 441620007510 trimer interface [polypeptide binding]; other site 441620007511 active site 441620007512 substrate binding site [chemical binding]; other site 441620007513 CoA binding site [chemical binding]; other site 441620007514 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 441620007515 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 441620007516 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 441620007517 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 441620007518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441620007519 Coenzyme A binding pocket [chemical binding]; other site 441620007520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 441620007521 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 441620007522 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 441620007523 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 441620007524 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441620007525 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441620007526 WHG domain; Region: WHG; pfam13305 441620007527 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 441620007528 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 441620007529 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 441620007530 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 441620007531 catalytic site [active] 441620007532 active site 441620007533 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 441620007534 putative bifunctional 4-alpha-glucanotransferase/malto-oligosyltrehalose synthase; Provisional; Region: PRK14507 441620007535 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 441620007536 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 441620007537 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 441620007538 active site 441620007539 catalytic site [active] 441620007540 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 441620007541 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 441620007542 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 441620007543 active site 441620007544 catalytic site [active] 441620007545 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 441620007546 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 441620007547 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 441620007548 active site 441620007549 homodimer interface [polypeptide binding]; other site 441620007550 catalytic site [active] 441620007551 acceptor binding site [chemical binding]; other site 441620007552 trehalose synthase; Region: treS_nterm; TIGR02456 441620007553 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 441620007554 active site 441620007555 catalytic site [active] 441620007556 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 441620007557 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 441620007558 glycogen branching enzyme; Provisional; Region: PRK05402 441620007559 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 441620007560 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 441620007561 active site 441620007562 catalytic site [active] 441620007563 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 441620007564 hypothetical protein; Provisional; Region: PRK02237 441620007565 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 441620007566 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 441620007567 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 441620007568 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 441620007569 minor groove reading motif; other site 441620007570 helix-hairpin-helix signature motif; other site 441620007571 substrate binding pocket [chemical binding]; other site 441620007572 active site 441620007573 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 441620007574 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 441620007575 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 441620007576 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 441620007577 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 441620007578 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 441620007579 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441620007580 FeS/SAM binding site; other site 441620007581 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 441620007582 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 441620007583 active site 441620007584 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 441620007585 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 441620007586 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 441620007587 P loop; other site 441620007588 GTP binding site [chemical binding]; other site 441620007589 Intracellular septation protein A; Region: IspA; pfam04279 441620007590 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 441620007591 phytoene desaturase; Region: crtI_fam; TIGR02734 441620007592 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 441620007593 substrate binding pocket [chemical binding]; other site 441620007594 chain length determination region; other site 441620007595 substrate-Mg2+ binding site; other site 441620007596 catalytic residues [active] 441620007597 aspartate-rich region 1; other site 441620007598 active site lid residues [active] 441620007599 aspartate-rich region 2; other site 441620007600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620007601 S-adenosylmethionine binding site [chemical binding]; other site 441620007602 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 441620007603 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 441620007604 putative NAD(P) binding site [chemical binding]; other site 441620007605 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441620007606 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 441620007607 Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY). Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980 441620007608 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 441620007609 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 441620007610 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 441620007611 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 441620007612 Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290 441620007613 subunit M interface; other site 441620007614 subunit H interface; other site 441620007615 quinone binding site; other site 441620007616 bacteriopheophytin binding site; other site 441620007617 bacteriochlorophyll binding site; other site 441620007618 cytochrome C subunit interface; other site 441620007619 Fe binding site [ion binding]; other site 441620007620 Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291 441620007621 subunit H interface; other site 441620007622 subunit L interface; other site 441620007623 bacteriopheophytin binding site; other site 441620007624 carotenoid binding site; other site 441620007625 bacteriochlorophyll binding site; other site 441620007626 cytochrome C interface; other site 441620007627 quinone binding site; other site 441620007628 Fe binding site [ion binding]; other site 441620007629 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cd09224 441620007630 subunit interface [polypeptide binding]; other site 441620007631 Heme binding sites [chemical binding]; other site 441620007632 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 441620007633 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441620007634 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 441620007635 Walker A/P-loop; other site 441620007636 ATP binding site [chemical binding]; other site 441620007637 Q-loop/lid; other site 441620007638 ABC transporter signature motif; other site 441620007639 Walker B; other site 441620007640 D-loop; other site 441620007641 H-loop/switch region; other site 441620007642 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 441620007643 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620007644 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620007645 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 441620007646 TPR repeat; Region: TPR_11; pfam13414 441620007647 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441620007648 binding surface 441620007649 TPR motif; other site 441620007650 TPR repeat; Region: TPR_11; pfam13414 441620007651 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 441620007652 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 441620007653 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 441620007654 pyruvate kinase; Provisional; Region: PRK06247 441620007655 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 441620007656 domain interfaces; other site 441620007657 active site 441620007658 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 441620007659 Protein of unknown function (DUF1036); Region: DUF1036; pfam06282 441620007660 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 441620007661 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 441620007662 MOFRL family; Region: MOFRL; pfam05161 441620007663 N-formylglutamate amidohydrolase; Region: FGase; cl01522 441620007664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 441620007665 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 441620007666 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 441620007667 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 441620007668 C-terminal domain interface [polypeptide binding]; other site 441620007669 GSH binding site (G-site) [chemical binding]; other site 441620007670 dimer interface [polypeptide binding]; other site 441620007671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 441620007672 Peptidase M15; Region: Peptidase_M15_3; cl01194 441620007673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 441620007674 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441620007675 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441620007676 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 441620007677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620007678 active site 441620007679 phosphorylation site [posttranslational modification] 441620007680 intermolecular recognition site; other site 441620007681 dimerization interface [polypeptide binding]; other site 441620007682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620007683 Walker A motif; other site 441620007684 ATP binding site [chemical binding]; other site 441620007685 Walker B motif; other site 441620007686 arginine finger; other site 441620007687 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441620007688 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 441620007689 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 441620007690 active site 441620007691 Zn binding site [ion binding]; other site 441620007692 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 441620007693 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 441620007694 ABC1 family; Region: ABC1; cl17513 441620007695 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 441620007696 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 441620007697 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 441620007698 ligand binding site [chemical binding]; other site 441620007699 homodimer interface [polypeptide binding]; other site 441620007700 NAD(P) binding site [chemical binding]; other site 441620007701 trimer interface B [polypeptide binding]; other site 441620007702 trimer interface A [polypeptide binding]; other site 441620007703 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 441620007704 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 441620007705 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 441620007706 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 441620007707 DHH family; Region: DHH; pfam01368 441620007708 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441620007709 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441620007710 ligand binding site [chemical binding]; other site 441620007711 flexible hinge region; other site 441620007712 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 441620007713 putative switch regulator; other site 441620007714 non-specific DNA interactions [nucleotide binding]; other site 441620007715 DNA binding site [nucleotide binding] 441620007716 sequence specific DNA binding site [nucleotide binding]; other site 441620007717 putative cAMP binding site [chemical binding]; other site 441620007718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620007719 HWE histidine kinase; Region: HWE_HK; smart00911 441620007720 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 441620007721 Surface antigen; Region: Bac_surface_Ag; pfam01103 441620007722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 441620007723 Family of unknown function (DUF490); Region: DUF490; pfam04357 441620007724 cyanate hydratase; Validated; Region: PRK02866 441620007725 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 441620007726 oligomer interface [polypeptide binding]; other site 441620007727 active site 441620007728 PAS domain; Region: PAS_9; pfam13426 441620007729 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620007730 putative active site [active] 441620007731 heme pocket [chemical binding]; other site 441620007732 PAS domain S-box; Region: sensory_box; TIGR00229 441620007733 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620007734 putative active site [active] 441620007735 heme pocket [chemical binding]; other site 441620007736 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620007737 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 441620007738 Walker A motif; other site 441620007739 ATP binding site [chemical binding]; other site 441620007740 Walker B motif; other site 441620007741 arginine finger; other site 441620007742 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 441620007743 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 441620007744 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 441620007745 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 441620007746 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441620007747 dimerization interface [polypeptide binding]; other site 441620007748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620007749 PAS fold; Region: PAS_7; pfam12860 441620007750 putative active site [active] 441620007751 heme pocket [chemical binding]; other site 441620007752 PAS domain; Region: PAS; smart00091 441620007753 PAS fold; Region: PAS_7; pfam12860 441620007754 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620007755 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620007756 metal binding site [ion binding]; metal-binding site 441620007757 active site 441620007758 I-site; other site 441620007759 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 441620007760 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 441620007761 dimanganese center [ion binding]; other site 441620007762 Domain of unknown function (DUF892); Region: DUF892; pfam05974 441620007763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441620007764 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 441620007765 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 441620007766 Cl- selectivity filter; other site 441620007767 Cl- binding residues [ion binding]; other site 441620007768 pore gating glutamate residue; other site 441620007769 dimer interface [polypeptide binding]; other site 441620007770 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 441620007771 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 441620007772 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 441620007773 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 441620007774 enolase; Provisional; Region: eno; PRK00077 441620007775 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 441620007776 dimer interface [polypeptide binding]; other site 441620007777 metal binding site [ion binding]; metal-binding site 441620007778 substrate binding pocket [chemical binding]; other site 441620007779 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 441620007780 Septum formation initiator; Region: DivIC; cl17659 441620007781 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 441620007782 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 441620007783 tetramer interface [polypeptide binding]; other site 441620007784 TPP-binding site [chemical binding]; other site 441620007785 heterodimer interface [polypeptide binding]; other site 441620007786 phosphorylation loop region [posttranslational modification] 441620007787 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 441620007788 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 441620007789 E3 interaction surface; other site 441620007790 lipoyl attachment site [posttranslational modification]; other site 441620007791 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 441620007792 alpha subunit interface [polypeptide binding]; other site 441620007793 TPP binding site [chemical binding]; other site 441620007794 heterodimer interface [polypeptide binding]; other site 441620007795 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 441620007796 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 441620007797 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 441620007798 E3 interaction surface; other site 441620007799 lipoyl attachment site [posttranslational modification]; other site 441620007800 e3 binding domain; Region: E3_binding; pfam02817 441620007801 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 441620007802 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 441620007803 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 441620007804 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441620007805 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 441620007806 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 441620007807 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441620007808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 441620007809 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 441620007810 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 441620007811 lipoyl synthase; Provisional; Region: PRK05481 441620007812 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441620007813 FeS/SAM binding site; other site 441620007814 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 441620007815 putative coenzyme Q binding site [chemical binding]; other site 441620007816 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 441620007817 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 441620007818 AsnC family; Region: AsnC_trans_reg; pfam01037 441620007819 ornithine cyclodeaminase; Validated; Region: PRK07589 441620007820 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 441620007821 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 441620007822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620007823 sequence-specific DNA binding site [nucleotide binding]; other site 441620007824 salt bridge; other site 441620007825 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 441620007826 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 441620007827 active site 441620007828 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441620007829 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 441620007830 Walker A/P-loop; other site 441620007831 ATP binding site [chemical binding]; other site 441620007832 Q-loop/lid; other site 441620007833 ABC transporter signature motif; other site 441620007834 Walker B; other site 441620007835 D-loop; other site 441620007836 H-loop/switch region; other site 441620007837 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 441620007838 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 441620007839 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441620007840 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 441620007841 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 441620007842 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 441620007843 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441620007844 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441620007845 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 441620007846 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 441620007847 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 441620007848 substrate binding site; other site 441620007849 dimer interface; other site 441620007850 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 441620007851 homotrimer interaction site [polypeptide binding]; other site 441620007852 zinc binding site [ion binding]; other site 441620007853 CDP-binding sites; other site 441620007854 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 441620007855 FMN binding site [chemical binding]; other site 441620007856 active site 441620007857 catalytic residues [active] 441620007858 substrate binding site [chemical binding]; other site 441620007859 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 441620007860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620007861 dimer interface [polypeptide binding]; other site 441620007862 phosphorylation site [posttranslational modification] 441620007863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620007864 ATP binding site [chemical binding]; other site 441620007865 Mg2+ binding site [ion binding]; other site 441620007866 G-X-G motif; other site 441620007867 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 441620007868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620007869 active site 441620007870 phosphorylation site [posttranslational modification] 441620007871 intermolecular recognition site; other site 441620007872 dimerization interface [polypeptide binding]; other site 441620007873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620007874 Walker A motif; other site 441620007875 ATP binding site [chemical binding]; other site 441620007876 Walker B motif; other site 441620007877 arginine finger; other site 441620007878 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 441620007879 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 441620007880 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441620007881 putative Mg++ binding site [ion binding]; other site 441620007882 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441620007883 nucleotide binding region [chemical binding]; other site 441620007884 ATP-binding site [chemical binding]; other site 441620007885 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 441620007886 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441620007887 dimerization interface [polypeptide binding]; other site 441620007888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620007889 putative active site [active] 441620007890 heme pocket [chemical binding]; other site 441620007891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620007892 dimer interface [polypeptide binding]; other site 441620007893 phosphorylation site [posttranslational modification] 441620007894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620007895 ATP binding site [chemical binding]; other site 441620007896 Mg2+ binding site [ion binding]; other site 441620007897 G-X-G motif; other site 441620007898 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 441620007899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620007900 active site 441620007901 phosphorylation site [posttranslational modification] 441620007902 intermolecular recognition site; other site 441620007903 dimerization interface [polypeptide binding]; other site 441620007904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620007905 Walker A motif; other site 441620007906 ATP binding site [chemical binding]; other site 441620007907 Walker B motif; other site 441620007908 arginine finger; other site 441620007909 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441620007910 bacterial Hfq-like; Region: Hfq; cd01716 441620007911 hexamer interface [polypeptide binding]; other site 441620007912 Sm1 motif; other site 441620007913 RNA binding site [nucleotide binding]; other site 441620007914 Sm2 motif; other site 441620007915 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 441620007916 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 441620007917 HflX GTPase family; Region: HflX; cd01878 441620007918 G1 box; other site 441620007919 GTP/Mg2+ binding site [chemical binding]; other site 441620007920 Switch I region; other site 441620007921 G2 box; other site 441620007922 G3 box; other site 441620007923 Switch II region; other site 441620007924 G4 box; other site 441620007925 G5 box; other site 441620007926 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 441620007927 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 441620007928 Sulfate transporter family; Region: Sulfate_transp; pfam00916 441620007929 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 441620007930 active site clefts [active] 441620007931 zinc binding site [ion binding]; other site 441620007932 dimer interface [polypeptide binding]; other site 441620007933 Domain of unknown function (DUF305); Region: DUF305; cl17794 441620007934 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 441620007935 Protein export membrane protein; Region: SecD_SecF; cl14618 441620007936 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 441620007937 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620007938 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 441620007939 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 441620007940 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 441620007941 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 441620007942 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 441620007943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441620007944 dimerization interface [polypeptide binding]; other site 441620007945 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441620007946 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620007947 dimer interface [polypeptide binding]; other site 441620007948 putative CheW interface [polypeptide binding]; other site 441620007949 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 441620007950 putative binding surface; other site 441620007951 active site 441620007952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620007953 ATP binding site [chemical binding]; other site 441620007954 Mg2+ binding site [ion binding]; other site 441620007955 G-X-G motif; other site 441620007956 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 441620007957 Response regulator receiver domain; Region: Response_reg; pfam00072 441620007958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620007959 active site 441620007960 phosphorylation site [posttranslational modification] 441620007961 intermolecular recognition site; other site 441620007962 dimerization interface [polypeptide binding]; other site 441620007963 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 441620007964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620007965 active site 441620007966 phosphorylation site [posttranslational modification] 441620007967 intermolecular recognition site; other site 441620007968 dimerization interface [polypeptide binding]; other site 441620007969 CheB methylesterase; Region: CheB_methylest; pfam01339 441620007970 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620007971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620007972 active site 441620007973 phosphorylation site [posttranslational modification] 441620007974 intermolecular recognition site; other site 441620007975 dimerization interface [polypeptide binding]; other site 441620007976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620007977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620007978 dimer interface [polypeptide binding]; other site 441620007979 phosphorylation site [posttranslational modification] 441620007980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620007981 ATP binding site [chemical binding]; other site 441620007982 Mg2+ binding site [ion binding]; other site 441620007983 G-X-G motif; other site 441620007984 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620007985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620007986 active site 441620007987 phosphorylation site [posttranslational modification] 441620007988 intermolecular recognition site; other site 441620007989 dimerization interface [polypeptide binding]; other site 441620007990 PAS fold; Region: PAS_4; pfam08448 441620007991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620007992 dimer interface [polypeptide binding]; other site 441620007993 phosphorylation site [posttranslational modification] 441620007994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620007995 ATP binding site [chemical binding]; other site 441620007996 Mg2+ binding site [ion binding]; other site 441620007997 G-X-G motif; other site 441620007998 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620007999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620008000 active site 441620008001 phosphorylation site [posttranslational modification] 441620008002 intermolecular recognition site; other site 441620008003 dimerization interface [polypeptide binding]; other site 441620008004 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 441620008005 FOG: WD40 repeat [General function prediction only]; Region: COG2319 441620008006 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 441620008007 structural tetrad; other site 441620008008 Cytochrome c; Region: Cytochrom_C; cl11414 441620008009 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 441620008010 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 441620008011 MPT binding site; other site 441620008012 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 441620008013 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 441620008014 dimer interface [polypeptide binding]; other site 441620008015 putative functional site; other site 441620008016 putative MPT binding site; other site 441620008017 PBP superfamily domain; Region: PBP_like; pfam12727 441620008018 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 441620008019 Walker A motif; other site 441620008020 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 441620008021 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 441620008022 dimer interface [polypeptide binding]; other site 441620008023 putative functional site; other site 441620008024 putative MPT binding site; other site 441620008025 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 441620008026 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 441620008027 dimerization interface [polypeptide binding]; other site 441620008028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 441620008029 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 441620008030 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 441620008031 Walker A/P-loop; other site 441620008032 ATP binding site [chemical binding]; other site 441620008033 Q-loop/lid; other site 441620008034 ABC transporter signature motif; other site 441620008035 Walker B; other site 441620008036 D-loop; other site 441620008037 H-loop/switch region; other site 441620008038 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 441620008039 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 441620008040 dimerization interface [polypeptide binding]; other site 441620008041 PRC-barrel domain; Region: PRC; pfam05239 441620008042 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 441620008043 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 441620008044 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 441620008045 Ligand binding site; other site 441620008046 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 441620008047 DXD motif; other site 441620008048 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 441620008049 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 441620008050 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441620008051 catalytic residue [active] 441620008052 TspO/MBR family; Region: TspO_MBR; pfam03073 441620008053 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 441620008054 FAD binding domain; Region: FAD_binding_4; pfam01565 441620008055 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 441620008056 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 441620008057 ligand binding site [chemical binding]; other site 441620008058 NAD binding site [chemical binding]; other site 441620008059 tetramer interface [polypeptide binding]; other site 441620008060 catalytic site [active] 441620008061 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 441620008062 L-serine binding site [chemical binding]; other site 441620008063 ACT domain interface; other site 441620008064 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620008065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620008066 active site 441620008067 phosphorylation site [posttranslational modification] 441620008068 intermolecular recognition site; other site 441620008069 dimerization interface [polypeptide binding]; other site 441620008070 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 441620008071 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441620008072 active site 441620008073 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 441620008074 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 441620008075 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 441620008076 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 441620008077 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441620008078 Walker A/P-loop; other site 441620008079 ATP binding site [chemical binding]; other site 441620008080 Q-loop/lid; other site 441620008081 ABC transporter signature motif; other site 441620008082 Walker B; other site 441620008083 D-loop; other site 441620008084 H-loop/switch region; other site 441620008085 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 441620008086 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 441620008087 Uncharacterized conserved protein [Function unknown]; Region: COG1434 441620008088 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 441620008089 putative active site [active] 441620008090 response regulator; Provisional; Region: PRK13435 441620008091 gamma-glutamyl kinase; Provisional; Region: PRK05429 441620008092 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 441620008093 nucleotide binding site [chemical binding]; other site 441620008094 homotetrameric interface [polypeptide binding]; other site 441620008095 putative phosphate binding site [ion binding]; other site 441620008096 putative allosteric binding site; other site 441620008097 PUA domain; Region: PUA; pfam01472 441620008098 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 441620008099 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 441620008100 putative catalytic cysteine [active] 441620008101 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 441620008102 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441620008103 active site 441620008104 KMSKS motif; other site 441620008105 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 441620008106 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 441620008107 Predicted transcriptional regulators [Transcription]; Region: COG1510 441620008108 MarR family; Region: MarR_2; pfam12802 441620008109 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 441620008110 active site 441620008111 catalytic residues [active] 441620008112 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441620008113 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441620008114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620008115 Walker A/P-loop; other site 441620008116 ATP binding site [chemical binding]; other site 441620008117 Q-loop/lid; other site 441620008118 ABC transporter signature motif; other site 441620008119 Walker B; other site 441620008120 D-loop; other site 441620008121 H-loop/switch region; other site 441620008122 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 441620008123 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 441620008124 intersubunit interface [polypeptide binding]; other site 441620008125 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 441620008126 MoaE interaction surface [polypeptide binding]; other site 441620008127 MoeB interaction surface [polypeptide binding]; other site 441620008128 thiocarboxylated glycine; other site 441620008129 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 441620008130 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 441620008131 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 441620008132 GIY-YIG motif/motif A; other site 441620008133 active site 441620008134 catalytic site [active] 441620008135 putative DNA binding site [nucleotide binding]; other site 441620008136 metal binding site [ion binding]; metal-binding site 441620008137 UvrB/uvrC motif; Region: UVR; pfam02151 441620008138 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 441620008139 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 441620008140 Predicted coiled-coil domain-containing protein (DUF2360); Region: DUF2360; pfam10152 441620008141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 441620008142 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441620008143 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 441620008144 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 441620008145 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 441620008146 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 441620008147 Uncharacterized conserved protein [Function unknown]; Region: COG1565 441620008148 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 441620008149 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 441620008150 MgtC family; Region: MgtC; pfam02308 441620008151 phosphoglucomutase; Region: PLN02307 441620008152 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 441620008153 substrate binding site [chemical binding]; other site 441620008154 dimer interface [polypeptide binding]; other site 441620008155 active site 441620008156 metal binding site [ion binding]; metal-binding site 441620008157 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 441620008158 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 441620008159 pyruvate phosphate dikinase; Provisional; Region: PRK09279 441620008160 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 441620008161 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 441620008162 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 441620008163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 441620008164 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441620008165 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 441620008166 dimer interface [polypeptide binding]; other site 441620008167 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 441620008168 metal binding site [ion binding]; metal-binding site 441620008169 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441620008170 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441620008171 ligand binding site [chemical binding]; other site 441620008172 flexible hinge region; other site 441620008173 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441620008174 MarR family; Region: MarR; pfam01047 441620008175 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 441620008176 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441620008177 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 441620008178 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 441620008179 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 441620008180 two-component response regulator; Provisional; Region: PRK09191 441620008181 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 441620008182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620008183 active site 441620008184 phosphorylation site [posttranslational modification] 441620008185 intermolecular recognition site; other site 441620008186 dimerization interface [polypeptide binding]; other site 441620008187 Flagellin N-methylase; Region: FliB; cl00497 441620008188 aminotransferase; Provisional; Region: PRK06105 441620008189 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 441620008190 inhibitor-cofactor binding pocket; inhibition site 441620008191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620008192 catalytic residue [active] 441620008193 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 441620008194 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 441620008195 putative active site [active] 441620008196 putative metal binding site [ion binding]; other site 441620008197 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441620008198 AlkA N-terminal domain; Region: AlkA_N; pfam06029 441620008199 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 441620008200 minor groove reading motif; other site 441620008201 helix-hairpin-helix signature motif; other site 441620008202 active site 441620008203 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 441620008204 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 441620008205 catalytic site [active] 441620008206 putative active site [active] 441620008207 putative substrate binding site [chemical binding]; other site 441620008208 HRDC domain; Region: HRDC; pfam00570 441620008209 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 441620008210 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 441620008211 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 441620008212 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 441620008213 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 441620008214 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 441620008215 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 441620008216 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 441620008217 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 441620008218 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 441620008219 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620008220 N-terminal plug; other site 441620008221 ligand-binding site [chemical binding]; other site 441620008222 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 441620008223 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 441620008224 putative active site [active] 441620008225 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 441620008226 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 441620008227 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 441620008228 active site 441620008229 catalytic site [active] 441620008230 substrate binding site [chemical binding]; other site 441620008231 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 441620008232 Part of AAA domain; Region: AAA_19; pfam13245 441620008233 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 441620008234 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 441620008235 active site 441620008236 metal binding site [ion binding]; metal-binding site 441620008237 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 441620008238 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 441620008239 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 441620008240 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 441620008241 ParB-like nuclease domain; Region: ParB; smart00470 441620008242 Methyltransferase domain; Region: Methyltransf_26; pfam13659 441620008243 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 441620008244 DEAD-like helicases superfamily; Region: DEXDc; smart00487 441620008245 Helicase_C-like; Region: Helicase_C_4; pfam13871 441620008246 Toprim domain; Region: Toprim_3; pfam13362 441620008247 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 441620008248 Uncharacterized conserved protein [Function unknown]; Region: COG5489 441620008249 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 441620008250 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 441620008251 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 441620008252 Helix-turn-helix domain; Region: HTH_17; pfam12728 441620008253 Replication initiator protein A; Region: RPA; pfam10134 441620008254 ParA-like protein; Provisional; Region: PHA02518 441620008255 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 441620008256 P-loop; other site 441620008257 Magnesium ion binding site [ion binding]; other site 441620008258 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 441620008259 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 441620008260 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 441620008261 Protein of unknown function (DUF736); Region: DUF736; pfam05284 441620008262 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 441620008263 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441620008264 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441620008265 catalytic residue [active] 441620008266 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 441620008267 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 441620008268 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 441620008269 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 441620008270 Walker A motif; other site 441620008271 ATP binding site [chemical binding]; other site 441620008272 Walker B motif; other site 441620008273 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 441620008274 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 441620008275 ATP binding site [chemical binding]; other site 441620008276 Walker A motif; other site 441620008277 hexamer interface [polypeptide binding]; other site 441620008278 Walker B motif; other site 441620008279 TrbC/VIRB2 family; Region: TrbC; cl01583 441620008280 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 441620008281 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 441620008282 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 441620008283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620008284 Walker A/P-loop; other site 441620008285 ATP binding site [chemical binding]; other site 441620008286 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 441620008287 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 441620008288 conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360 441620008289 conjugal transfer protein TrbL; Provisional; Region: PRK13875 441620008290 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 441620008291 conjugal transfer protein TrbF; Provisional; Region: PRK13872 441620008292 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 441620008293 VirB7 interaction site; other site 441620008294 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 441620008295 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 441620008296 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620008297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620008298 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 441620008299 dimerization interface [polypeptide binding]; other site 441620008300 substrate binding pocket [chemical binding]; other site 441620008301 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 441620008302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441620008303 ATP binding site [chemical binding]; other site 441620008304 putative Mg++ binding site [ion binding]; other site 441620008305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441620008306 nucleotide binding region [chemical binding]; other site 441620008307 ATP-binding site [chemical binding]; other site 441620008308 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 441620008309 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 441620008310 WYL domain; Region: WYL; pfam13280 441620008311 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 441620008312 Part of AAA domain; Region: AAA_19; pfam13245 441620008313 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 441620008314 AAA domain; Region: AAA_12; pfam13087 441620008315 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 441620008316 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 441620008317 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 441620008318 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 441620008319 catalytic residues [active] 441620008320 catalytic nucleophile [active] 441620008321 Recombinase; Region: Recombinase; pfam07508 441620008322 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 441620008323 putative DNA binding site [nucleotide binding]; other site 441620008324 putative Zn2+ binding site [ion binding]; other site 441620008325 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 441620008326 integrase; Provisional; Region: PRK09692 441620008327 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 441620008328 active site 441620008329 Int/Topo IB signature motif; other site 441620008330 GMP synthase; Reviewed; Region: guaA; PRK00074 441620008331 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 441620008332 AMP/PPi binding site [chemical binding]; other site 441620008333 candidate oxyanion hole; other site 441620008334 catalytic triad [active] 441620008335 potential glutamine specificity residues [chemical binding]; other site 441620008336 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 441620008337 ATP Binding subdomain [chemical binding]; other site 441620008338 Ligand Binding sites [chemical binding]; other site 441620008339 Dimerization subdomain; other site 441620008340 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 441620008341 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 441620008342 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 441620008343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620008344 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 441620008345 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 441620008346 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 441620008347 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 441620008348 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 441620008349 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 441620008350 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 441620008351 active site 441620008352 cell division protein FtsW; Region: ftsW; TIGR02614 441620008353 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 441620008354 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 441620008355 active site 441620008356 homodimer interface [polypeptide binding]; other site 441620008357 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 441620008358 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 441620008359 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441620008360 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441620008361 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 441620008362 FAD binding domain; Region: FAD_binding_4; pfam01565 441620008363 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 441620008364 YcfA-like protein; Region: YcfA; pfam07927 441620008365 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 441620008366 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 441620008367 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 441620008368 ATP-grasp domain; Region: ATP-grasp_4; cl17255 441620008369 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 441620008370 Cell division protein FtsQ; Region: FtsQ; pfam03799 441620008371 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 441620008372 Cell division protein FtsA; Region: FtsA; smart00842 441620008373 Cell division protein FtsA; Region: FtsA; pfam14450 441620008374 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 441620008375 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 441620008376 nucleotide binding site [chemical binding]; other site 441620008377 SulA interaction site; other site 441620008378 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 441620008379 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 441620008380 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 441620008381 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 441620008382 Core-2/I-Branching enzyme; Region: Branch; pfam02485 441620008383 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 441620008384 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 441620008385 Walker A/P-loop; other site 441620008386 ATP binding site [chemical binding]; other site 441620008387 Q-loop/lid; other site 441620008388 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 441620008389 ABC transporter signature motif; other site 441620008390 Walker B; other site 441620008391 D-loop; other site 441620008392 H-loop/switch region; other site 441620008393 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 441620008394 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 441620008395 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 441620008396 putative molybdopterin cofactor binding site [chemical binding]; other site 441620008397 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 441620008398 putative molybdopterin cofactor binding site; other site 441620008399 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 441620008400 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 441620008401 nucleotide binding site [chemical binding]; other site 441620008402 NEF interaction site [polypeptide binding]; other site 441620008403 SBD interface [polypeptide binding]; other site 441620008404 chaperone protein DnaJ; Provisional; Region: PRK10767 441620008405 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 441620008406 HSP70 interaction site [polypeptide binding]; other site 441620008407 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 441620008408 substrate binding site [polypeptide binding]; other site 441620008409 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 441620008410 Zn binding sites [ion binding]; other site 441620008411 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 441620008412 dimer interface [polypeptide binding]; other site 441620008413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620008414 S-adenosylmethionine binding site [chemical binding]; other site 441620008415 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 441620008416 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 441620008417 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 441620008418 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 441620008419 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 441620008420 intersubunit interface [polypeptide binding]; other site 441620008421 active site 441620008422 catalytic residue [active] 441620008423 purine nucleoside phosphorylase; Provisional; Region: PRK08202 441620008424 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 441620008425 active site 441620008426 catalytic motif [active] 441620008427 Zn binding site [ion binding]; other site 441620008428 Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; pfam09866 441620008429 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 441620008430 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 441620008431 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 441620008432 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 441620008433 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 441620008434 putative acyl-acceptor binding pocket; other site 441620008435 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 441620008436 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 441620008437 putative active site [active] 441620008438 putative metal binding site [ion binding]; other site 441620008439 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 441620008440 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 441620008441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620008442 active site 441620008443 phosphorylation site [posttranslational modification] 441620008444 intermolecular recognition site; other site 441620008445 dimerization interface [polypeptide binding]; other site 441620008446 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 441620008447 DNA-binding site [nucleotide binding]; DNA binding site 441620008448 RNA-binding motif; other site 441620008449 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 441620008450 DNA-binding site [nucleotide binding]; DNA binding site 441620008451 RNA-binding motif; other site 441620008452 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 441620008453 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 441620008454 interface (dimer of trimers) [polypeptide binding]; other site 441620008455 Substrate-binding/catalytic site; other site 441620008456 Zn-binding sites [ion binding]; other site 441620008457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 441620008458 binding surface 441620008459 TPR motif; other site 441620008460 TPR repeat; Region: TPR_11; pfam13414 441620008461 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441620008462 binding surface 441620008463 TPR motif; other site 441620008464 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 441620008465 Predicted permeases [General function prediction only]; Region: COG0679 441620008466 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 441620008467 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441620008468 active site 441620008469 nucleotide binding site [chemical binding]; other site 441620008470 HIGH motif; other site 441620008471 KMSKS motif; other site 441620008472 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 441620008473 oligomeric interface; other site 441620008474 putative active site [active] 441620008475 homodimer interface [polypeptide binding]; other site 441620008476 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 441620008477 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 441620008478 peptide chain release factor 2; Provisional; Region: PRK07342 441620008479 This domain is found in peptide chain release factors; Region: PCRF; smart00937 441620008480 RF-1 domain; Region: RF-1; pfam00472 441620008481 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 441620008482 Peptidase family M23; Region: Peptidase_M23; pfam01551 441620008483 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 441620008484 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 441620008485 catalytic triad [active] 441620008486 Protein of unknown function; Region: DUF3971; pfam13116 441620008487 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 441620008488 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 441620008489 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 441620008490 active site 441620008491 HIGH motif; other site 441620008492 dimer interface [polypeptide binding]; other site 441620008493 KMSKS motif; other site 441620008494 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441620008495 RNA binding surface [nucleotide binding]; other site 441620008496 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 441620008497 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 441620008498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620008499 sequence-specific DNA binding site [nucleotide binding]; other site 441620008500 salt bridge; other site 441620008501 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 441620008502 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 441620008503 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 441620008504 Tetramer interface [polypeptide binding]; other site 441620008505 active site 441620008506 FMN-binding site [chemical binding]; other site 441620008507 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 441620008508 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 441620008509 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 441620008510 dimerization interface [polypeptide binding]; other site 441620008511 active site 441620008512 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 441620008513 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 441620008514 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 441620008515 putative active site [active] 441620008516 Zn binding site [ion binding]; other site 441620008517 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 441620008518 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 441620008519 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 441620008520 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 441620008521 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 441620008522 carboxyltransferase (CT) interaction site; other site 441620008523 biotinylation site [posttranslational modification]; other site 441620008524 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 441620008525 putative active site pocket [active] 441620008526 dimerization interface [polypeptide binding]; other site 441620008527 putative catalytic residue [active] 441620008528 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 441620008529 Acylphosphatase; Region: Acylphosphatase; pfam00708 441620008530 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 441620008531 Protein of unknown function, DUF599; Region: DUF599; pfam04654 441620008532 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 441620008533 Uncharacterized conserved protein [Function unknown]; Region: COG1434 441620008534 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 441620008535 putative active site [active] 441620008536 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 441620008537 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 441620008538 putative C-terminal domain interface [polypeptide binding]; other site 441620008539 putative GSH binding site (G-site) [chemical binding]; other site 441620008540 putative dimer interface [polypeptide binding]; other site 441620008541 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 441620008542 putative N-terminal domain interface [polypeptide binding]; other site 441620008543 putative dimer interface [polypeptide binding]; other site 441620008544 putative substrate binding pocket (H-site) [chemical binding]; other site 441620008545 lysine-2,3-aminomutase-related protein; Region: AblA_like_2; TIGR03822 441620008546 Radical SAM superfamily; Region: Radical_SAM; pfam04055 441620008547 FeS/SAM binding site; other site 441620008548 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 441620008549 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 441620008550 motif 1; other site 441620008551 dimer interface [polypeptide binding]; other site 441620008552 active site 441620008553 motif 2; other site 441620008554 motif 3; other site 441620008555 elongation factor P; Validated; Region: PRK00529 441620008556 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 441620008557 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 441620008558 RNA binding site [nucleotide binding]; other site 441620008559 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 441620008560 RNA binding site [nucleotide binding]; other site 441620008561 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 441620008562 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 441620008563 DNA-binding site [nucleotide binding]; DNA binding site 441620008564 RNA-binding motif; other site 441620008565 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 441620008566 DNA-binding site [nucleotide binding]; DNA binding site 441620008567 RNA-binding motif; other site 441620008568 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 441620008569 magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406 441620008570 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 441620008571 metal ion-dependent adhesion site (MIDAS); other site 441620008572 putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056 441620008573 phytoene desaturase; Region: crtI_fam; TIGR02734 441620008574 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 441620008575 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 441620008576 active site lid residues [active] 441620008577 substrate binding pocket [chemical binding]; other site 441620008578 catalytic residues [active] 441620008579 substrate-Mg2+ binding site; other site 441620008580 aspartate-rich region 1; other site 441620008581 aspartate-rich region 2; other site 441620008582 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441620008583 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 441620008584 UreF; Region: UreF; pfam01730 441620008585 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 441620008586 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 441620008587 dimer interface [polypeptide binding]; other site 441620008588 catalytic residues [active] 441620008589 urease subunit alpha; Reviewed; Region: ureC; PRK13207 441620008590 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 441620008591 subunit interactions [polypeptide binding]; other site 441620008592 active site 441620008593 flap region; other site 441620008594 Predicted membrane protein [Function unknown]; Region: COG4420 441620008595 HD domain; Region: HD_4; pfam13328 441620008596 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 441620008597 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 441620008598 alpha-gamma subunit interface [polypeptide binding]; other site 441620008599 beta-gamma subunit interface [polypeptide binding]; other site 441620008600 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 441620008601 alpha-beta subunit interface [polypeptide binding]; other site 441620008602 UreD urease accessory protein; Region: UreD; pfam01774 441620008603 Flavin Reductases; Region: FlaRed; cl00801 441620008604 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 441620008605 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 441620008606 active site 441620008607 homotetramer interface [polypeptide binding]; other site 441620008608 GcrA cell cycle regulator; Region: GcrA; cl11564 441620008609 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441620008610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620008611 NAD(P) binding site [chemical binding]; other site 441620008612 active site 441620008613 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 441620008614 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 441620008615 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 441620008616 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 441620008617 threonine dehydratase; Reviewed; Region: PRK09224 441620008618 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 441620008619 tetramer interface [polypeptide binding]; other site 441620008620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620008621 catalytic residue [active] 441620008622 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 441620008623 putative Ile/Val binding site [chemical binding]; other site 441620008624 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 441620008625 putative Ile/Val binding site [chemical binding]; other site 441620008626 PilZ domain; Region: PilZ; pfam07238 441620008627 SlyX; Region: SlyX; pfam04102 441620008628 Porin subfamily; Region: Porin_2; pfam02530 441620008629 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 441620008630 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 441620008631 AAA domain; Region: AAA_30; pfam13604 441620008632 Family description; Region: UvrD_C_2; pfam13538 441620008633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 441620008634 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441620008635 DNA binding site [nucleotide binding] 441620008636 active site 441620008637 Int/Topo IB signature motif; other site 441620008638 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 441620008639 DNA binding site [nucleotide binding] 441620008640 active site 441620008641 Int/Topo IB signature motif; other site 441620008642 catalytic residues [active] 441620008643 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 441620008644 active site 441620008645 Int/Topo IB signature motif; other site 441620008646 catalytic residues [active] 441620008647 DNA binding site [nucleotide binding] 441620008648 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 441620008649 Class II flagellar assembly regulator; Region: FliX; pfam10768 441620008650 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 441620008651 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 441620008652 Rod binding protein; Region: Rod-binding; cl01626 441620008653 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 441620008654 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 441620008655 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786 441620008656 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 441620008657 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 441620008658 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 441620008659 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441620008660 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 441620008661 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 441620008662 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 441620008663 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK12785 441620008664 flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795 441620008665 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 441620008666 Uncharacterized conserved protein [Function unknown]; Region: COG3334 441620008667 Protein of unknown function (DUF433); Region: DUF433; pfam04255 441620008668 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 441620008669 catalytic residues [active] 441620008670 dimer interface [polypeptide binding]; other site 441620008671 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 441620008672 Transglycosylase SLT domain; Region: SLT_2; pfam13406 441620008673 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441620008674 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441620008675 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441620008676 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 441620008677 Uncharacterized conserved protein [Function unknown]; Region: COG3791 441620008678 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 441620008679 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 441620008680 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 441620008681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620008682 dimer interface [polypeptide binding]; other site 441620008683 phosphorylation site [posttranslational modification] 441620008684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620008685 ATP binding site [chemical binding]; other site 441620008686 Mg2+ binding site [ion binding]; other site 441620008687 G-X-G motif; other site 441620008688 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 441620008689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620008690 active site 441620008691 phosphorylation site [posttranslational modification] 441620008692 intermolecular recognition site; other site 441620008693 dimerization interface [polypeptide binding]; other site 441620008694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620008695 Walker A motif; other site 441620008696 ATP binding site [chemical binding]; other site 441620008697 Walker B motif; other site 441620008698 arginine finger; other site 441620008699 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 441620008700 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620008701 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620008702 metal binding site [ion binding]; metal-binding site 441620008703 active site 441620008704 I-site; other site 441620008705 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 441620008706 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 441620008707 GatB domain; Region: GatB_Yqey; smart00845 441620008708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620008709 S-adenosylmethionine binding site [chemical binding]; other site 441620008710 Cation efflux family; Region: Cation_efflux; pfam01545 441620008711 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 441620008712 FAD binding domain; Region: FAD_binding_3; pfam01494 441620008713 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 441620008714 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 441620008715 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 441620008716 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 441620008717 active site 441620008718 NTP binding site [chemical binding]; other site 441620008719 metal binding triad [ion binding]; metal-binding site 441620008720 antibiotic binding site [chemical binding]; other site 441620008721 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 441620008722 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 441620008723 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 441620008724 Leucine rich repeat; Region: LRR_8; pfam13855 441620008725 Leucine rich repeat; Region: LRR_8; pfam13855 441620008726 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 441620008727 Uncharacterized conserved protein [Function unknown]; Region: COG3025 441620008728 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 441620008729 putative active site [active] 441620008730 putative metal binding residues [ion binding]; other site 441620008731 signature motif; other site 441620008732 putative triphosphate binding site [ion binding]; other site 441620008733 CHAD domain; Region: CHAD; pfam05235 441620008734 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 441620008735 putative active site [active] 441620008736 putative metal binding residues [ion binding]; other site 441620008737 signature motif; other site 441620008738 putative dimer interface [polypeptide binding]; other site 441620008739 putative phosphate binding site [ion binding]; other site 441620008740 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 441620008741 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 441620008742 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441620008743 catalytic loop [active] 441620008744 iron binding site [ion binding]; other site 441620008745 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 441620008746 cyclase homology domain; Region: CHD; cd07302 441620008747 nucleotidyl binding site; other site 441620008748 metal binding site [ion binding]; metal-binding site 441620008749 dimer interface [polypeptide binding]; other site 441620008750 Major royal jelly protein; Region: MRJP; pfam03022 441620008751 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 441620008752 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 441620008753 aminotransferase; Validated; Region: PRK09148 441620008754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441620008755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620008756 homodimer interface [polypeptide binding]; other site 441620008757 catalytic residue [active] 441620008758 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 441620008759 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 441620008760 putative cation:proton antiport protein; Provisional; Region: PRK10669 441620008761 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 441620008762 TrkA-N domain; Region: TrkA_N; pfam02254 441620008763 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 441620008764 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 441620008765 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 441620008766 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 441620008767 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 441620008768 dimer interface [polypeptide binding]; other site 441620008769 motif 1; other site 441620008770 active site 441620008771 motif 2; other site 441620008772 motif 3; other site 441620008773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441620008774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441620008775 SnoaL-like domain; Region: SnoaL_2; pfam12680 441620008776 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 441620008777 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 441620008778 tandem repeat interface [polypeptide binding]; other site 441620008779 oligomer interface [polypeptide binding]; other site 441620008780 active site residues [active] 441620008781 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 441620008782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620008783 S-adenosylmethionine binding site [chemical binding]; other site 441620008784 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 441620008785 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 441620008786 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 441620008787 substrate binding pocket [chemical binding]; other site 441620008788 chain length determination region; other site 441620008789 substrate-Mg2+ binding site; other site 441620008790 catalytic residues [active] 441620008791 aspartate-rich region 1; other site 441620008792 active site lid residues [active] 441620008793 aspartate-rich region 2; other site 441620008794 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 441620008795 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 441620008796 active site 441620008797 NTP binding site [chemical binding]; other site 441620008798 metal binding triad [ion binding]; metal-binding site 441620008799 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441620008800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441620008801 binding surface 441620008802 TPR motif; other site 441620008803 TPR repeat; Region: TPR_11; pfam13414 441620008804 TPR repeat; Region: TPR_11; pfam13414 441620008805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441620008806 binding surface 441620008807 TPR motif; other site 441620008808 TPR repeat; Region: TPR_11; pfam13414 441620008809 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 441620008810 iron-sulfur cluster [ion binding]; other site 441620008811 [2Fe-2S] cluster binding site [ion binding]; other site 441620008812 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 441620008813 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441620008814 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 441620008815 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 441620008816 active site 441620008817 non-prolyl cis peptide bond; other site 441620008818 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 441620008819 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 441620008820 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 441620008821 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441620008822 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 441620008823 Walker A/P-loop; other site 441620008824 ATP binding site [chemical binding]; other site 441620008825 Q-loop/lid; other site 441620008826 ABC transporter signature motif; other site 441620008827 Walker B; other site 441620008828 D-loop; other site 441620008829 H-loop/switch region; other site 441620008830 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 441620008831 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 441620008832 putative active site [active] 441620008833 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 441620008834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620008835 ATP binding site [chemical binding]; other site 441620008836 Mg2+ binding site [ion binding]; other site 441620008837 G-X-G motif; other site 441620008838 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 441620008839 anchoring element; other site 441620008840 dimer interface [polypeptide binding]; other site 441620008841 ATP binding site [chemical binding]; other site 441620008842 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 441620008843 active site 441620008844 metal binding site [ion binding]; metal-binding site 441620008845 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 441620008846 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 441620008847 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 441620008848 tetramer interface [polypeptide binding]; other site 441620008849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620008850 catalytic residue [active] 441620008851 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441620008852 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441620008853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620008854 Walker A/P-loop; other site 441620008855 ATP binding site [chemical binding]; other site 441620008856 Q-loop/lid; other site 441620008857 ABC transporter signature motif; other site 441620008858 Walker B; other site 441620008859 D-loop; other site 441620008860 H-loop/switch region; other site 441620008861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620008862 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441620008863 putative substrate translocation pore; other site 441620008864 PRC-barrel domain; Region: PRC; pfam05239 441620008865 PRC-barrel domain; Region: PRC; pfam05239 441620008866 SWIB/MDM2 domain; Region: SWIB; pfam02201 441620008867 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 441620008868 classical (c) SDRs; Region: SDR_c; cd05233 441620008869 NAD(P) binding site [chemical binding]; other site 441620008870 active site 441620008871 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441620008872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620008873 putative substrate translocation pore; other site 441620008874 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 441620008875 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 441620008876 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 441620008877 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 441620008878 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 441620008879 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 441620008880 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 441620008881 C-terminal domain interface [polypeptide binding]; other site 441620008882 GSH binding site (G-site) [chemical binding]; other site 441620008883 dimer interface [polypeptide binding]; other site 441620008884 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 441620008885 N-terminal domain interface [polypeptide binding]; other site 441620008886 putative dimer interface [polypeptide binding]; other site 441620008887 active site 441620008888 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 441620008889 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 441620008890 nucleoside/Zn binding site; other site 441620008891 dimer interface [polypeptide binding]; other site 441620008892 catalytic motif [active] 441620008893 spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886 441620008894 Short C-terminal domain; Region: SHOCT; pfam09851 441620008895 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 441620008896 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 441620008897 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 441620008898 active site 441620008899 catalytic site [active] 441620008900 histidine kinase; Provisional; Region: PRK13557 441620008901 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620008902 putative active site [active] 441620008903 heme pocket [chemical binding]; other site 441620008904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620008905 dimer interface [polypeptide binding]; other site 441620008906 phosphorylation site [posttranslational modification] 441620008907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620008908 ATP binding site [chemical binding]; other site 441620008909 Mg2+ binding site [ion binding]; other site 441620008910 G-X-G motif; other site 441620008911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620008912 active site 441620008913 phosphorylation site [posttranslational modification] 441620008914 intermolecular recognition site; other site 441620008915 dimerization interface [polypeptide binding]; other site 441620008916 isocitrate dehydrogenase; Validated; Region: PRK08299 441620008917 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 441620008918 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 441620008919 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 441620008920 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 441620008921 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 441620008922 putative NAD(P) binding site [chemical binding]; other site 441620008923 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 441620008924 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 441620008925 dimerization interface [polypeptide binding]; other site 441620008926 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620008927 dimer interface [polypeptide binding]; other site 441620008928 putative CheW interface [polypeptide binding]; other site 441620008929 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 441620008930 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 441620008931 homodimer interface [polypeptide binding]; other site 441620008932 substrate-cofactor binding pocket; other site 441620008933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620008934 catalytic residue [active] 441620008935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620008936 active site 441620008937 phosphorylation site [posttranslational modification] 441620008938 intermolecular recognition site; other site 441620008939 dimerization interface [polypeptide binding]; other site 441620008940 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 441620008941 Cysteine-rich domain; Region: CCG; pfam02754 441620008942 Cysteine-rich domain; Region: CCG; pfam02754 441620008943 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 441620008944 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 441620008945 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 441620008946 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441620008947 ATP binding site [chemical binding]; other site 441620008948 putative Mg++ binding site [ion binding]; other site 441620008949 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441620008950 nucleotide binding region [chemical binding]; other site 441620008951 ATP-binding site [chemical binding]; other site 441620008952 DEAD/H associated; Region: DEAD_assoc; pfam08494 441620008953 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 441620008954 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 441620008955 putative active site [active] 441620008956 putative metal binding site [ion binding]; other site 441620008957 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 441620008958 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 441620008959 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 441620008960 putative ion selectivity filter; other site 441620008961 putative pore gating glutamate residue; other site 441620008962 putative H+/Cl- coupling transport residue; other site 441620008963 short chain dehydrogenase; Provisional; Region: PRK06197 441620008964 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 441620008965 putative NAD(P) binding site [chemical binding]; other site 441620008966 active site 441620008967 thiamine monophosphate kinase; Provisional; Region: PRK05731 441620008968 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 441620008969 ATP binding site [chemical binding]; other site 441620008970 dimerization interface [polypeptide binding]; other site 441620008971 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 441620008972 putative RNA binding site [nucleotide binding]; other site 441620008973 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 441620008974 homopentamer interface [polypeptide binding]; other site 441620008975 active site 441620008976 hypothetical protein; Validated; Region: PRK08238 441620008977 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 441620008978 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 441620008979 Predicted membrane protein [Function unknown]; Region: COG2246 441620008980 GtrA-like protein; Region: GtrA; pfam04138 441620008981 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 441620008982 Lumazine binding domain; Region: Lum_binding; pfam00677 441620008983 Lumazine binding domain; Region: Lum_binding; pfam00677 441620008984 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 441620008985 catalytic motif [active] 441620008986 Zn binding site [ion binding]; other site 441620008987 RibD C-terminal domain; Region: RibD_C; cl17279 441620008988 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 441620008989 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 441620008990 ATP cone domain; Region: ATP-cone; pfam03477 441620008991 Transcriptional regulator; Region: Rrf2; cl17282 441620008992 Predicted transcriptional regulator [Transcription]; Region: COG1959 441620008993 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 441620008994 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 441620008995 dimer interface [polypeptide binding]; other site 441620008996 active site 441620008997 glycine-pyridoxal phosphate binding site [chemical binding]; other site 441620008998 folate binding site [chemical binding]; other site 441620008999 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 441620009000 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 441620009001 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 441620009002 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 441620009003 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 441620009004 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 441620009005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 441620009006 Thioredoxin; Region: Thioredoxin_4; pfam13462 441620009007 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 441620009008 Protein of unknown function (DUF721); Region: DUF721; cl02324 441620009009 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 441620009010 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 441620009011 minor groove reading motif; other site 441620009012 helix-hairpin-helix signature motif; other site 441620009013 substrate binding pocket [chemical binding]; other site 441620009014 active site 441620009015 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 441620009016 DNA binding and oxoG recognition site [nucleotide binding] 441620009017 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 441620009018 DNA methylase; Region: N6_N4_Mtase; pfam01555 441620009019 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 441620009020 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 441620009021 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 441620009022 ABC transporter ATPase component; Reviewed; Region: PRK11147 441620009023 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441620009024 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441620009025 Porin subfamily; Region: Porin_2; pfam02530 441620009026 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 441620009027 ligand binding site [chemical binding]; other site 441620009028 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 441620009029 cyclase homology domain; Region: CHD; cd07302 441620009030 nucleotidyl binding site; other site 441620009031 metal binding site [ion binding]; metal-binding site 441620009032 dimer interface [polypeptide binding]; other site 441620009033 HD domain; Region: HD_3; pfam13023 441620009034 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 441620009035 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441620009036 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441620009037 catalytic residue [active] 441620009038 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 441620009039 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 441620009040 dimer interface [polypeptide binding]; other site 441620009041 active site 441620009042 catalytic residue [active] 441620009043 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 441620009044 SmpB-tmRNA interface; other site 441620009045 Uncharacterized conserved protein [Function unknown]; Region: COG1432 441620009046 LabA_like proteins; Region: LabA; cd10911 441620009047 putative metal binding site [ion binding]; other site 441620009048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441620009049 active site 441620009050 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 441620009051 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441620009052 Zn2+ binding site [ion binding]; other site 441620009053 Mg2+ binding site [ion binding]; other site 441620009054 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 441620009055 synthetase active site [active] 441620009056 NTP binding site [chemical binding]; other site 441620009057 metal binding site [ion binding]; metal-binding site 441620009058 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 441620009059 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 441620009060 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 441620009061 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 441620009062 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 441620009063 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 441620009064 Glycoprotease family; Region: Peptidase_M22; pfam00814 441620009065 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 441620009066 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441620009067 Coenzyme A binding pocket [chemical binding]; other site 441620009068 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 441620009069 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 441620009070 putative acyl-acceptor binding pocket; other site 441620009071 MEKHLA domain; Region: MEKHLA; pfam08670 441620009072 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620009073 putative active site [active] 441620009074 heme pocket [chemical binding]; other site 441620009075 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 441620009076 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 441620009077 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441620009078 FeS/SAM binding site; other site 441620009079 TRAM domain; Region: TRAM; pfam01938 441620009080 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 441620009081 PhoH-like protein; Region: PhoH; pfam02562 441620009082 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 441620009083 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 441620009084 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 441620009085 Transporter associated domain; Region: CorC_HlyC; smart01091 441620009086 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 441620009087 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 441620009088 putative active site [active] 441620009089 catalytic triad [active] 441620009090 putative dimer interface [polypeptide binding]; other site 441620009091 BA14K-like protein; Region: BA14K; pfam07886 441620009092 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 441620009093 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 441620009094 tetramer interface [polypeptide binding]; other site 441620009095 heme binding pocket [chemical binding]; other site 441620009096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620009097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620009098 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 441620009099 dimerization interface [polypeptide binding]; other site 441620009100 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 441620009101 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 441620009102 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 441620009103 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 441620009104 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 441620009105 putative active site [active] 441620009106 putative metal binding site [ion binding]; other site 441620009107 glutamate racemase; Provisional; Region: PRK00865 441620009108 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 441620009109 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 441620009110 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 441620009111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441620009112 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 441620009113 Protein of unknown function (DUF992); Region: DUF992; pfam06186 441620009114 Protein of unknown function (DUF779); Region: DUF779; pfam05610 441620009115 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 441620009116 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 441620009117 [4Fe-4S] binding site [ion binding]; other site 441620009118 molybdopterin cofactor binding site; other site 441620009119 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 441620009120 molybdopterin cofactor binding site; other site 441620009121 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 441620009122 siroheme synthase; Provisional; Region: cysG; PRK10637 441620009123 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 441620009124 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 441620009125 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 441620009126 active site 441620009127 SAM binding site [chemical binding]; other site 441620009128 homodimer interface [polypeptide binding]; other site 441620009129 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 441620009130 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 441620009131 Cu(I) binding site [ion binding]; other site 441620009132 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441620009133 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 441620009134 active site 441620009135 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 441620009136 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441620009137 substrate binding pocket [chemical binding]; other site 441620009138 membrane-bound complex binding site; other site 441620009139 hinge residues; other site 441620009140 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 441620009141 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 441620009142 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 441620009143 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 441620009144 metal ion-dependent adhesion site (MIDAS); other site 441620009145 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 441620009146 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 441620009147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 441620009148 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 441620009149 HSP70 interaction site [polypeptide binding]; other site 441620009150 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 441620009151 hypothetical protein; Provisional; Region: PRK09256 441620009152 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 441620009153 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 441620009154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441620009155 binding surface 441620009156 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 441620009157 TPR motif; other site 441620009158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441620009159 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 441620009160 DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120 441620009161 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 441620009162 active site 441620009163 DNA binding site [nucleotide binding] 441620009164 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 441620009165 DNA binding site [nucleotide binding] 441620009166 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 441620009167 Protein of unknown function, DUF606; Region: DUF606; pfam04657 441620009168 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 441620009169 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620009170 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 441620009171 putative dimerization interface [polypeptide binding]; other site 441620009172 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 441620009173 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 441620009174 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 441620009175 substrate binding site [chemical binding]; other site 441620009176 oxyanion hole (OAH) forming residues; other site 441620009177 trimer interface [polypeptide binding]; other site 441620009178 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 441620009179 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 441620009180 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 441620009181 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 441620009182 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 441620009183 dimer interface [polypeptide binding]; other site 441620009184 active site 441620009185 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 441620009186 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 441620009187 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 441620009188 FAD binding site [chemical binding]; other site 441620009189 substrate binding site [chemical binding]; other site 441620009190 catalytic residues [active] 441620009191 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 441620009192 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 441620009193 Sel1-like repeats; Region: SEL1; smart00671 441620009194 Sel1-like repeats; Region: SEL1; smart00671 441620009195 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 441620009196 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 441620009197 active site 441620009198 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 441620009199 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 441620009200 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 441620009201 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 441620009202 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 441620009203 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 441620009204 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 441620009205 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 441620009206 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 441620009207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620009208 catalytic residue [active] 441620009209 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 441620009210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 441620009211 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 441620009212 Subunit III/VIIa interface [polypeptide binding]; other site 441620009213 Phospholipid binding site [chemical binding]; other site 441620009214 Subunit I/III interface [polypeptide binding]; other site 441620009215 Subunit III/VIb interface [polypeptide binding]; other site 441620009216 Subunit III/VIa interface; other site 441620009217 Subunit III/Vb interface [polypeptide binding]; other site 441620009218 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; pfam04442 441620009219 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 441620009220 UbiA prenyltransferase family; Region: UbiA; pfam01040 441620009221 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 441620009222 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 441620009223 Subunit I/III interface [polypeptide binding]; other site 441620009224 D-pathway; other site 441620009225 Subunit I/VIIc interface [polypeptide binding]; other site 441620009226 Subunit I/IV interface [polypeptide binding]; other site 441620009227 Subunit I/II interface [polypeptide binding]; other site 441620009228 Low-spin heme (heme a) binding site [chemical binding]; other site 441620009229 Subunit I/VIIa interface [polypeptide binding]; other site 441620009230 Subunit I/VIa interface [polypeptide binding]; other site 441620009231 Dimer interface; other site 441620009232 Putative water exit pathway; other site 441620009233 Binuclear center (heme a3/CuB) [ion binding]; other site 441620009234 K-pathway; other site 441620009235 Subunit I/Vb interface [polypeptide binding]; other site 441620009236 Putative proton exit pathway; other site 441620009237 Subunit I/VIb interface; other site 441620009238 Subunit I/VIc interface [polypeptide binding]; other site 441620009239 Electron transfer pathway; other site 441620009240 Subunit I/VIIIb interface [polypeptide binding]; other site 441620009241 Subunit I/VIIb interface [polypeptide binding]; other site 441620009242 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 441620009243 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 441620009244 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 441620009245 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 441620009246 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 441620009247 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 441620009248 active site 441620009249 dimer interface [polypeptide binding]; other site 441620009250 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 441620009251 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 441620009252 active site 441620009253 FMN binding site [chemical binding]; other site 441620009254 substrate binding site [chemical binding]; other site 441620009255 3Fe-4S cluster binding site [ion binding]; other site 441620009256 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 441620009257 domain interface; other site 441620009258 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 441620009259 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 441620009260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 441620009261 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 441620009262 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 441620009263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620009264 Mg2+ binding site [ion binding]; other site 441620009265 G-X-G motif; other site 441620009266 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441620009267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620009268 active site 441620009269 phosphorylation site [posttranslational modification] 441620009270 intermolecular recognition site; other site 441620009271 dimerization interface [polypeptide binding]; other site 441620009272 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441620009273 DNA binding residues [nucleotide binding] 441620009274 dimerization interface [polypeptide binding]; other site 441620009275 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 441620009276 active site 441620009277 catalytic triad [active] 441620009278 oxyanion hole [active] 441620009279 Transglycosylase SLT domain; Region: SLT_2; pfam13406 441620009280 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441620009281 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441620009282 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441620009283 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 441620009284 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 441620009285 NAD binding site [chemical binding]; other site 441620009286 homodimer interface [polypeptide binding]; other site 441620009287 active site 441620009288 substrate binding site [chemical binding]; other site 441620009289 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 441620009290 active site 441620009291 tetramer interface; other site 441620009292 N-formylglutamate amidohydrolase; Region: FGase; cl01522 441620009293 Response regulator receiver domain; Region: Response_reg; pfam00072 441620009294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620009295 active site 441620009296 phosphorylation site [posttranslational modification] 441620009297 intermolecular recognition site; other site 441620009298 dimerization interface [polypeptide binding]; other site 441620009299 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 441620009300 GSH binding site [chemical binding]; other site 441620009301 catalytic residues [active] 441620009302 Predicted amidohydrolase [General function prediction only]; Region: COG0388 441620009303 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 441620009304 putative active site [active] 441620009305 catalytic triad [active] 441620009306 dimer interface [polypeptide binding]; other site 441620009307 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 441620009308 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620009309 PAS domain; Region: PAS_9; pfam13426 441620009310 putative active site [active] 441620009311 heme pocket [chemical binding]; other site 441620009312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620009313 Histidine kinase; Region: HisKA_2; pfam07568 441620009314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620009315 ATP binding site [chemical binding]; other site 441620009316 Mg2+ binding site [ion binding]; other site 441620009317 G-X-G motif; other site 441620009318 methionine sulfoxide reductase A; Provisional; Region: PRK00058 441620009319 hypothetical protein; Provisional; Region: PRK05208 441620009320 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 441620009321 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 441620009322 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 441620009323 PRC-barrel domain; Region: PRC; pfam05239 441620009324 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 441620009325 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 441620009326 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 441620009327 catalytic residues [active] 441620009328 argininosuccinate lyase; Provisional; Region: PRK00855 441620009329 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 441620009330 active sites [active] 441620009331 tetramer interface [polypeptide binding]; other site 441620009332 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 441620009333 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441620009334 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 441620009335 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 441620009336 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 441620009337 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441620009338 motif II; other site 441620009339 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 441620009340 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 441620009341 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 441620009342 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 441620009343 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 441620009344 PAS domain; Region: PAS_8; pfam13188 441620009345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620009346 PAS fold; Region: PAS_3; pfam08447 441620009347 putative active site [active] 441620009348 heme pocket [chemical binding]; other site 441620009349 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620009350 PAS fold; Region: PAS_3; pfam08447 441620009351 putative active site [active] 441620009352 heme pocket [chemical binding]; other site 441620009353 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620009354 HWE histidine kinase; Region: HWE_HK; pfam07536 441620009355 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 441620009356 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 441620009357 Probable Catalytic site; other site 441620009358 metal-binding site 441620009359 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441620009360 active site 441620009361 Peptidase family M48; Region: Peptidase_M48; pfam01435 441620009362 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441620009363 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441620009364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620009365 non-specific DNA binding site [nucleotide binding]; other site 441620009366 salt bridge; other site 441620009367 sequence-specific DNA binding site [nucleotide binding]; other site 441620009368 S-adenosylmethionine synthetase; Validated; Region: PRK05250 441620009369 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 441620009370 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 441620009371 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 441620009372 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 441620009373 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 441620009374 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 441620009375 active site 441620009376 interdomain interaction site; other site 441620009377 putative metal-binding site [ion binding]; other site 441620009378 nucleotide binding site [chemical binding]; other site 441620009379 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 441620009380 domain I; other site 441620009381 DNA binding groove [nucleotide binding] 441620009382 phosphate binding site [ion binding]; other site 441620009383 domain II; other site 441620009384 domain III; other site 441620009385 nucleotide binding site [chemical binding]; other site 441620009386 catalytic site [active] 441620009387 domain IV; other site 441620009388 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 441620009389 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 441620009390 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 441620009391 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 441620009392 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 441620009393 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 441620009394 Moco binding site; other site 441620009395 metal coordination site [ion binding]; other site 441620009396 Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292 441620009397 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 441620009398 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 441620009399 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 441620009400 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 441620009401 dihydroorotase; Validated; Region: PRK09059 441620009402 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 441620009403 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 441620009404 active site 441620009405 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 441620009406 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 441620009407 DNA protecting protein DprA; Region: dprA; TIGR00732 441620009408 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 441620009409 active site 441620009410 catalytic triad [active] 441620009411 oxyanion hole [active] 441620009412 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 441620009413 conserved cys residue [active] 441620009414 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 441620009415 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 441620009416 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 441620009417 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 441620009418 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 441620009419 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 441620009420 GIY-YIG motif/motif A; other site 441620009421 putative active site [active] 441620009422 putative metal binding site [ion binding]; other site 441620009423 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 441620009424 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441620009425 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620009426 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620009427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 441620009428 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441620009429 Bacterial sugar transferase; Region: Bac_transf; pfam02397 441620009430 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620009431 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 441620009432 putative ADP-binding pocket [chemical binding]; other site 441620009433 Chain length determinant protein; Region: Wzz; cl15801 441620009434 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 441620009435 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 441620009436 SLBB domain; Region: SLBB; pfam10531 441620009437 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 441620009438 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 441620009439 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620009440 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441620009441 active site 441620009442 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 441620009443 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 441620009444 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 441620009445 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441620009446 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620009447 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 441620009448 trimer interface [polypeptide binding]; other site 441620009449 active site 441620009450 substrate binding site [chemical binding]; other site 441620009451 CoA binding site [chemical binding]; other site 441620009452 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 441620009453 active site 441620009454 catalytic residues [active] 441620009455 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441620009456 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 441620009457 Methyltransferase domain; Region: Methyltransf_23; pfam13489 441620009458 Methyltransferase domain; Region: Methyltransf_12; pfam08242 441620009459 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 441620009460 active site 441620009461 catalytic residues [active] 441620009462 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 441620009463 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 441620009464 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 441620009465 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 441620009466 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 441620009467 Substrate binding site; other site 441620009468 Cupin domain; Region: Cupin_2; cl17218 441620009469 Response regulator receiver domain; Region: Response_reg; pfam00072 441620009470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620009471 active site 441620009472 phosphorylation site [posttranslational modification] 441620009473 intermolecular recognition site; other site 441620009474 dimerization interface [polypeptide binding]; other site 441620009475 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 441620009476 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 441620009477 active site 441620009478 substrate binding site [chemical binding]; other site 441620009479 metal binding site [ion binding]; metal-binding site 441620009480 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 441620009481 putative hydrophobic ligand binding site [chemical binding]; other site 441620009482 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 441620009483 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 441620009484 Walker A/P-loop; other site 441620009485 ATP binding site [chemical binding]; other site 441620009486 Q-loop/lid; other site 441620009487 ABC transporter signature motif; other site 441620009488 Walker B; other site 441620009489 D-loop; other site 441620009490 H-loop/switch region; other site 441620009491 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 441620009492 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 441620009493 Walker A/P-loop; other site 441620009494 ATP binding site [chemical binding]; other site 441620009495 Q-loop/lid; other site 441620009496 ABC transporter signature motif; other site 441620009497 Walker B; other site 441620009498 D-loop; other site 441620009499 H-loop/switch region; other site 441620009500 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 441620009501 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 441620009502 TM-ABC transporter signature motif; other site 441620009503 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 441620009504 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 441620009505 TM-ABC transporter signature motif; other site 441620009506 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 441620009507 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 441620009508 putative ligand binding site [chemical binding]; other site 441620009509 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 441620009510 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441620009511 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441620009512 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 441620009513 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 441620009514 catalytic loop [active] 441620009515 iron binding site [ion binding]; other site 441620009516 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441620009517 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 441620009518 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 441620009519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441620009520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441620009521 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 441620009522 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 441620009523 multimer interface [polypeptide binding]; other site 441620009524 active site 441620009525 catalytic triad [active] 441620009526 dimer interface [polypeptide binding]; other site 441620009527 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 441620009528 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 441620009529 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 441620009530 hypothetical protein; Validated; Region: PRK07581 441620009531 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 441620009532 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 441620009533 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 441620009534 Walker A/P-loop; other site 441620009535 ATP binding site [chemical binding]; other site 441620009536 Q-loop/lid; other site 441620009537 ABC transporter signature motif; other site 441620009538 Walker B; other site 441620009539 D-loop; other site 441620009540 H-loop/switch region; other site 441620009541 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 441620009542 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 441620009543 Walker A/P-loop; other site 441620009544 ATP binding site [chemical binding]; other site 441620009545 Q-loop/lid; other site 441620009546 ABC transporter signature motif; other site 441620009547 Walker B; other site 441620009548 D-loop; other site 441620009549 H-loop/switch region; other site 441620009550 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 441620009551 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 441620009552 TM-ABC transporter signature motif; other site 441620009553 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 441620009554 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 441620009555 TM-ABC transporter signature motif; other site 441620009556 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 441620009557 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 441620009558 putative ligand binding site [chemical binding]; other site 441620009559 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 441620009560 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620009561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620009562 dimer interface [polypeptide binding]; other site 441620009563 phosphorylation site [posttranslational modification] 441620009564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620009565 ATP binding site [chemical binding]; other site 441620009566 Mg2+ binding site [ion binding]; other site 441620009567 G-X-G motif; other site 441620009568 Response regulator receiver domain; Region: Response_reg; pfam00072 441620009569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620009570 active site 441620009571 phosphorylation site [posttranslational modification] 441620009572 intermolecular recognition site; other site 441620009573 dimerization interface [polypeptide binding]; other site 441620009574 Response regulator receiver domain; Region: Response_reg; pfam00072 441620009575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620009576 active site 441620009577 phosphorylation site [posttranslational modification] 441620009578 intermolecular recognition site; other site 441620009579 dimerization interface [polypeptide binding]; other site 441620009580 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441620009581 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441620009582 DNA binding residues [nucleotide binding] 441620009583 dimerization interface [polypeptide binding]; other site 441620009584 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 441620009585 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 441620009586 active site 441620009587 SAM binding site [chemical binding]; other site 441620009588 homodimer interface [polypeptide binding]; other site 441620009589 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 441620009590 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 441620009591 P-loop; other site 441620009592 Magnesium ion binding site [ion binding]; other site 441620009593 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 441620009594 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 441620009595 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 441620009596 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 441620009597 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 441620009598 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 441620009599 active site 441620009600 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 441620009601 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 441620009602 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 441620009603 active site 441620009604 HIGH motif; other site 441620009605 KMSK motif region; other site 441620009606 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 441620009607 tRNA binding surface [nucleotide binding]; other site 441620009608 anticodon binding site; other site 441620009609 Sporulation related domain; Region: SPOR; pfam05036 441620009610 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 441620009611 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 441620009612 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 441620009613 sec-independent translocase; Provisional; Region: tatB; PRK00404 441620009614 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 441620009615 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 441620009616 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 441620009617 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620009618 heme pocket [chemical binding]; other site 441620009619 putative active site [active] 441620009620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620009621 putative active site [active] 441620009622 heme pocket [chemical binding]; other site 441620009623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620009624 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441620009625 putative substrate translocation pore; other site 441620009626 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 441620009627 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 441620009628 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 441620009629 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441620009630 substrate binding pocket [chemical binding]; other site 441620009631 membrane-bound complex binding site; other site 441620009632 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 441620009633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620009634 dimer interface [polypeptide binding]; other site 441620009635 conserved gate region; other site 441620009636 putative PBP binding loops; other site 441620009637 ABC-ATPase subunit interface; other site 441620009638 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441620009639 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441620009640 Walker A/P-loop; other site 441620009641 ATP binding site [chemical binding]; other site 441620009642 Q-loop/lid; other site 441620009643 ABC transporter signature motif; other site 441620009644 Walker B; other site 441620009645 D-loop; other site 441620009646 H-loop/switch region; other site 441620009647 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 441620009648 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 441620009649 active site 441620009650 dimer interface [polypeptide binding]; other site 441620009651 non-prolyl cis peptide bond; other site 441620009652 insertion regions; other site 441620009653 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 441620009654 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441620009655 substrate binding pocket [chemical binding]; other site 441620009656 membrane-bound complex binding site; other site 441620009657 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 441620009658 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441620009659 substrate binding pocket [chemical binding]; other site 441620009660 membrane-bound complex binding site; other site 441620009661 hinge residues; other site 441620009662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 441620009663 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 441620009664 cytidine deaminase; Provisional; Region: PRK09027 441620009665 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 441620009666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 441620009667 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 441620009668 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 441620009669 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 441620009670 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 441620009671 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 441620009672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 441620009673 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 441620009674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 441620009675 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 441620009676 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 441620009677 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 441620009678 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 441620009679 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441620009680 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441620009681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620009682 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 441620009683 classical (c) SDRs; Region: SDR_c; cd05233 441620009684 NAD(P) binding site [chemical binding]; other site 441620009685 active site 441620009686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620009687 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 441620009688 putative substrate translocation pore; other site 441620009689 Beta-lactamase; Region: Beta-lactamase; pfam00144 441620009690 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 441620009691 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 441620009692 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 441620009693 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 441620009694 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 441620009695 NAD(P) binding site [chemical binding]; other site 441620009696 catalytic residues [active] 441620009697 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 441620009698 SnoaL-like domain; Region: SnoaL_2; pfam12680 441620009699 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 441620009700 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 441620009701 dimer interface [polypeptide binding]; other site 441620009702 active site 441620009703 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441620009704 catalytic residues [active] 441620009705 substrate binding site [chemical binding]; other site 441620009706 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 441620009707 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441620009708 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441620009709 acyl-activating enzyme (AAE) consensus motif; other site 441620009710 acyl-activating enzyme (AAE) consensus motif; other site 441620009711 AMP binding site [chemical binding]; other site 441620009712 active site 441620009713 CoA binding site [chemical binding]; other site 441620009714 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 441620009715 Predicted membrane protein [Function unknown]; Region: COG2259 441620009716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620009717 putative transporter; Provisional; Region: PRK10504 441620009718 putative substrate translocation pore; other site 441620009719 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 441620009720 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 441620009721 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 441620009722 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 441620009723 active site 441620009724 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 441620009725 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 441620009726 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 441620009727 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 441620009728 SnoaL-like domain; Region: SnoaL_3; pfam13474 441620009729 exopolyphosphatase; Region: exo_poly_only; TIGR03706 441620009730 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 441620009731 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 441620009732 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 441620009733 active site 441620009734 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 441620009735 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 441620009736 putative acyl-acceptor binding pocket; other site 441620009737 phytoene desaturase; Region: crtI_fam; TIGR02734 441620009738 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 441620009739 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 441620009740 catalytic triad [active] 441620009741 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 441620009742 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 441620009743 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441620009744 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 441620009745 Walker A/P-loop; other site 441620009746 ATP binding site [chemical binding]; other site 441620009747 Q-loop/lid; other site 441620009748 ABC transporter signature motif; other site 441620009749 Walker B; other site 441620009750 D-loop; other site 441620009751 H-loop/switch region; other site 441620009752 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 441620009753 phytoene desaturase; Region: crtI_fam; TIGR02734 441620009754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441620009755 Domain of unknown function DUF87; Region: DUF87; pfam01935 441620009756 HerA helicase [Replication, recombination, and repair]; Region: COG0433 441620009757 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 441620009758 putative active site [active] 441620009759 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 441620009760 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 441620009761 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 441620009762 dimer interaction site [polypeptide binding]; other site 441620009763 substrate-binding tunnel; other site 441620009764 active site 441620009765 catalytic site [active] 441620009766 substrate binding site [chemical binding]; other site 441620009767 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 441620009768 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 441620009769 putative active site [active] 441620009770 putative metal binding site [ion binding]; other site 441620009771 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 441620009772 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 441620009773 putative C-terminal domain interface [polypeptide binding]; other site 441620009774 putative GSH binding site (G-site) [chemical binding]; other site 441620009775 putative dimer interface [polypeptide binding]; other site 441620009776 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 441620009777 dimer interface [polypeptide binding]; other site 441620009778 N-terminal domain interface [polypeptide binding]; other site 441620009779 putative substrate binding pocket (H-site) [chemical binding]; other site 441620009780 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 441620009781 putative membrane protein; Region: HpnL; TIGR03476 441620009782 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 441620009783 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 441620009784 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 441620009785 ligand binding site; other site 441620009786 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 441620009787 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 441620009788 B12 binding site [chemical binding]; other site 441620009789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441620009790 FeS/SAM binding site; other site 441620009791 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 441620009792 putative active site [active] 441620009793 YdjC motif; other site 441620009794 Mg binding site [ion binding]; other site 441620009795 putative homodimer interface [polypeptide binding]; other site 441620009796 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 441620009797 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 441620009798 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441620009799 FeS/SAM binding site; other site 441620009800 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 441620009801 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 441620009802 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 441620009803 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 441620009804 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 441620009805 AAA domain; Region: AAA_33; pfam13671 441620009806 ATP-binding site [chemical binding]; other site 441620009807 Gluconate-6-phosphate binding site [chemical binding]; other site 441620009808 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441620009809 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 441620009810 active site 441620009811 motif I; other site 441620009812 motif II; other site 441620009813 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 441620009814 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441620009815 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441620009816 catalytic residue [active] 441620009817 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 441620009818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 441620009819 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 441620009820 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 441620009821 putative acyltransferase; Provisional; Region: PRK05790 441620009822 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 441620009823 dimer interface [polypeptide binding]; other site 441620009824 active site 441620009825 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 441620009826 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 441620009827 NAD(P) binding site [chemical binding]; other site 441620009828 homotetramer interface [polypeptide binding]; other site 441620009829 homodimer interface [polypeptide binding]; other site 441620009830 active site 441620009831 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 441620009832 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 441620009833 putative acyl-acceptor binding pocket; other site 441620009834 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 441620009835 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 441620009836 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 441620009837 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 441620009838 FAD binding domain; Region: FAD_binding_4; pfam01565 441620009839 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 441620009840 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 441620009841 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 441620009842 nudix motif; other site 441620009843 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441620009844 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 441620009845 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 441620009846 putative N-terminal domain interface [polypeptide binding]; other site 441620009847 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 441620009848 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 441620009849 putative dimer interface [polypeptide binding]; other site 441620009850 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 441620009851 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 441620009852 putative dimer interface [polypeptide binding]; other site 441620009853 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 441620009854 SPW repeat; Region: SPW; pfam03779 441620009855 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 441620009856 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620009857 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620009858 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 441620009859 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 441620009860 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 441620009861 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 441620009862 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 441620009863 Cytochrome C biogenesis protein; Region: CcmH; cl01179 441620009864 cyclase homology domain; Region: CHD; cd07302 441620009865 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 441620009866 dimer interface [polypeptide binding]; other site 441620009867 nucleotidyl binding site; other site 441620009868 metal binding site [ion binding]; metal-binding site 441620009869 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 441620009870 cyclase homology domain; Region: CHD; cd07302 441620009871 nucleotidyl binding site; other site 441620009872 metal binding site [ion binding]; metal-binding site 441620009873 dimer interface [polypeptide binding]; other site 441620009874 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 441620009875 ATP binding site [chemical binding]; other site 441620009876 substrate interface [chemical binding]; other site 441620009877 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 441620009878 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441620009879 dimerization interface [polypeptide binding]; other site 441620009880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620009881 dimer interface [polypeptide binding]; other site 441620009882 phosphorylation site [posttranslational modification] 441620009883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620009884 ATP binding site [chemical binding]; other site 441620009885 Mg2+ binding site [ion binding]; other site 441620009886 G-X-G motif; other site 441620009887 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 441620009888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620009889 active site 441620009890 phosphorylation site [posttranslational modification] 441620009891 intermolecular recognition site; other site 441620009892 dimerization interface [polypeptide binding]; other site 441620009893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620009894 Walker A motif; other site 441620009895 ATP binding site [chemical binding]; other site 441620009896 Walker B motif; other site 441620009897 arginine finger; other site 441620009898 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441620009899 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441620009900 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 441620009901 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620009902 N-terminal plug; other site 441620009903 ligand-binding site [chemical binding]; other site 441620009904 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 441620009905 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 441620009906 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620009907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620009908 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 441620009909 dimerization interface [polypeptide binding]; other site 441620009910 formate dehydrogenase; Provisional; Region: PRK07574 441620009911 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 441620009912 dimerization interface [polypeptide binding]; other site 441620009913 ligand binding site [chemical binding]; other site 441620009914 NAD binding site [chemical binding]; other site 441620009915 catalytic site [active] 441620009916 HPP family; Region: HPP; pfam04982 441620009917 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 441620009918 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 441620009919 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 441620009920 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 441620009921 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 441620009922 dimer interface [polypeptide binding]; other site 441620009923 putative functional site; other site 441620009924 putative MPT binding site; other site 441620009925 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 441620009926 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 441620009927 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 441620009928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620009929 dimer interface [polypeptide binding]; other site 441620009930 conserved gate region; other site 441620009931 putative PBP binding loops; other site 441620009932 ABC-ATPase subunit interface; other site 441620009933 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 441620009934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620009935 Walker A/P-loop; other site 441620009936 ATP binding site [chemical binding]; other site 441620009937 Q-loop/lid; other site 441620009938 ABC transporter signature motif; other site 441620009939 Walker B; other site 441620009940 D-loop; other site 441620009941 H-loop/switch region; other site 441620009942 TOBE domain; Region: TOBE; cl01440 441620009943 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 441620009944 Transposase, Mutator family; Region: Transposase_mut; pfam00872 441620009945 MULE transposase domain; Region: MULE; pfam10551 441620009946 HipA-like N-terminal domain; Region: HipA_N; pfam07805 441620009947 HipA-like C-terminal domain; Region: HipA_C; pfam07804 441620009948 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441620009949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620009950 non-specific DNA binding site [nucleotide binding]; other site 441620009951 salt bridge; other site 441620009952 sequence-specific DNA binding site [nucleotide binding]; other site 441620009953 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 441620009954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620009955 Walker A motif; other site 441620009956 ATP binding site [chemical binding]; other site 441620009957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 441620009958 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 441620009959 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 441620009960 putative dimer interface [polypeptide binding]; other site 441620009961 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 441620009962 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 441620009963 putative dimer interface [polypeptide binding]; other site 441620009964 thioredoxin 2; Provisional; Region: PRK10996 441620009965 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 441620009966 catalytic residues [active] 441620009967 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620009968 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 441620009969 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620009970 Histidine kinase; Region: HisKA_2; pfam07568 441620009971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620009972 ATP binding site [chemical binding]; other site 441620009973 Mg2+ binding site [ion binding]; other site 441620009974 G-X-G motif; other site 441620009975 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 441620009976 Clp amino terminal domain; Region: Clp_N; pfam02861 441620009977 Clp amino terminal domain; Region: Clp_N; pfam02861 441620009978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620009979 Walker A motif; other site 441620009980 ATP binding site [chemical binding]; other site 441620009981 Walker B motif; other site 441620009982 arginine finger; other site 441620009983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620009984 Walker A motif; other site 441620009985 ATP binding site [chemical binding]; other site 441620009986 Walker B motif; other site 441620009987 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 441620009988 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 441620009989 30S subunit binding site; other site 441620009990 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 441620009991 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 441620009992 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 441620009993 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 441620009994 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 441620009995 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 441620009996 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 441620009997 PRC-barrel domain; Region: PRC; pfam05239 441620009998 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620009999 PAS fold; Region: PAS_3; pfam08447 441620010000 putative active site [active] 441620010001 heme pocket [chemical binding]; other site 441620010002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 441620010003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620010004 ATP binding site [chemical binding]; other site 441620010005 Mg2+ binding site [ion binding]; other site 441620010006 G-X-G motif; other site 441620010007 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441620010008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620010009 active site 441620010010 phosphorylation site [posttranslational modification] 441620010011 intermolecular recognition site; other site 441620010012 dimerization interface [polypeptide binding]; other site 441620010013 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441620010014 DNA binding residues [nucleotide binding] 441620010015 dimerization interface [polypeptide binding]; other site 441620010016 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 441620010017 Predicted membrane protein [Function unknown]; Region: COG4325 441620010018 MgtC family; Region: MgtC; pfam02308 441620010019 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 441620010020 Peptidase family M50; Region: Peptidase_M50; pfam02163 441620010021 active site 441620010022 putative substrate binding region [chemical binding]; other site 441620010023 FOG: CBS domain [General function prediction only]; Region: COG0517 441620010024 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 441620010025 Found in ATP-dependent protease La (LON); Region: LON; smart00464 441620010026 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 441620010027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620010028 Walker A motif; other site 441620010029 ATP binding site [chemical binding]; other site 441620010030 Walker B motif; other site 441620010031 arginine finger; other site 441620010032 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 441620010033 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 441620010034 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 441620010035 putative dimer interface [polypeptide binding]; other site 441620010036 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 441620010037 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 441620010038 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 441620010039 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 441620010040 DNA binding residues [nucleotide binding] 441620010041 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 441620010042 chaperone protein DnaJ; Provisional; Region: PRK14299 441620010043 HSP70 interaction site [polypeptide binding]; other site 441620010044 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 441620010045 substrate binding site [polypeptide binding]; other site 441620010046 dimer interface [polypeptide binding]; other site 441620010047 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 441620010048 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 441620010049 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441620010050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620010051 non-specific DNA binding site [nucleotide binding]; other site 441620010052 salt bridge; other site 441620010053 sequence-specific DNA binding site [nucleotide binding]; other site 441620010054 Homeodomain-like domain; Region: HTH_23; cl17451 441620010055 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 441620010056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620010057 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 441620010058 putative dimerization interface [polypeptide binding]; other site 441620010059 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 441620010060 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 441620010061 putative ligand binding site [chemical binding]; other site 441620010062 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 441620010063 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 441620010064 TM-ABC transporter signature motif; other site 441620010065 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 441620010066 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 441620010067 TM-ABC transporter signature motif; other site 441620010068 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 441620010069 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 441620010070 Walker A/P-loop; other site 441620010071 ATP binding site [chemical binding]; other site 441620010072 Q-loop/lid; other site 441620010073 ABC transporter signature motif; other site 441620010074 Walker B; other site 441620010075 D-loop; other site 441620010076 H-loop/switch region; other site 441620010077 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 441620010078 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 441620010079 Walker A/P-loop; other site 441620010080 ATP binding site [chemical binding]; other site 441620010081 Q-loop/lid; other site 441620010082 ABC transporter signature motif; other site 441620010083 Walker B; other site 441620010084 D-loop; other site 441620010085 H-loop/switch region; other site 441620010086 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 441620010087 putative amidase; Provisional; Region: PRK06169 441620010088 Amidase; Region: Amidase; cl11426 441620010089 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 441620010090 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 441620010091 NMT1-like family; Region: NMT1_2; pfam13379 441620010092 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620010093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620010094 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 441620010095 dimerization interface [polypeptide binding]; other site 441620010096 Transposase, Mutator family; Region: Transposase_mut; pfam00872 441620010097 MULE transposase domain; Region: MULE; pfam10551 441620010098 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 441620010099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 441620010100 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 441620010101 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 441620010102 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 441620010103 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 441620010104 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441620010105 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441620010106 Walker A/P-loop; other site 441620010107 ATP binding site [chemical binding]; other site 441620010108 Q-loop/lid; other site 441620010109 ABC transporter signature motif; other site 441620010110 Walker B; other site 441620010111 D-loop; other site 441620010112 H-loop/switch region; other site 441620010113 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 441620010114 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 441620010115 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 441620010116 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 441620010117 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 441620010118 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 441620010119 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 441620010120 PAS domain; Region: PAS_9; pfam13426 441620010121 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620010122 putative active site [active] 441620010123 heme pocket [chemical binding]; other site 441620010124 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620010125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620010126 dimer interface [polypeptide binding]; other site 441620010127 phosphorylation site [posttranslational modification] 441620010128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620010129 ATP binding site [chemical binding]; other site 441620010130 Mg2+ binding site [ion binding]; other site 441620010131 G-X-G motif; other site 441620010132 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620010133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620010134 active site 441620010135 phosphorylation site [posttranslational modification] 441620010136 intermolecular recognition site; other site 441620010137 dimerization interface [polypeptide binding]; other site 441620010138 PAS fold; Region: PAS_4; pfam08448 441620010139 PAS domain S-box; Region: sensory_box; TIGR00229 441620010140 PAS domain; Region: PAS_8; pfam13188 441620010141 PAS fold; Region: PAS_4; pfam08448 441620010142 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620010143 putative active site [active] 441620010144 heme pocket [chemical binding]; other site 441620010145 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 441620010146 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 441620010147 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 441620010148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620010149 dimer interface [polypeptide binding]; other site 441620010150 phosphorylation site [posttranslational modification] 441620010151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620010152 ATP binding site [chemical binding]; other site 441620010153 Mg2+ binding site [ion binding]; other site 441620010154 G-X-G motif; other site 441620010155 Response regulator receiver domain; Region: Response_reg; pfam00072 441620010156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620010157 active site 441620010158 phosphorylation site [posttranslational modification] 441620010159 intermolecular recognition site; other site 441620010160 dimerization interface [polypeptide binding]; other site 441620010161 PAS fold; Region: PAS_3; pfam08447 441620010162 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 441620010163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620010164 dimer interface [polypeptide binding]; other site 441620010165 phosphorylation site [posttranslational modification] 441620010166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620010167 ATP binding site [chemical binding]; other site 441620010168 Mg2+ binding site [ion binding]; other site 441620010169 G-X-G motif; other site 441620010170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620010171 active site 441620010172 phosphorylation site [posttranslational modification] 441620010173 intermolecular recognition site; other site 441620010174 dimerization interface [polypeptide binding]; other site 441620010175 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 441620010176 Domain of unknown function (DUF892); Region: DUF892; pfam05974 441620010177 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 441620010178 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620010179 N-terminal plug; other site 441620010180 ligand-binding site [chemical binding]; other site 441620010181 AAA domain; Region: AAA_33; pfam13671 441620010182 AAA domain; Region: AAA_17; pfam13207 441620010183 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 441620010184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620010185 Walker A/P-loop; other site 441620010186 ATP binding site [chemical binding]; other site 441620010187 Q-loop/lid; other site 441620010188 ABC transporter signature motif; other site 441620010189 Walker B; other site 441620010190 D-loop; other site 441620010191 H-loop/switch region; other site 441620010192 FecCD transport family; Region: FecCD; pfam01032 441620010193 putative PBP binding regions; other site 441620010194 ABC-ATPase subunit interface; other site 441620010195 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 441620010196 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 441620010197 intersubunit interface [polypeptide binding]; other site 441620010198 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 441620010199 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620010200 N-terminal plug; other site 441620010201 ligand-binding site [chemical binding]; other site 441620010202 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 441620010203 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620010204 N-terminal plug; other site 441620010205 ligand-binding site [chemical binding]; other site 441620010206 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 441620010207 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 441620010208 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 441620010209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620010210 dimer interface [polypeptide binding]; other site 441620010211 conserved gate region; other site 441620010212 putative PBP binding loops; other site 441620010213 ABC-ATPase subunit interface; other site 441620010214 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 441620010215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620010216 ABC-ATPase subunit interface; other site 441620010217 putative PBP binding loops; other site 441620010218 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 441620010219 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441620010220 Walker A/P-loop; other site 441620010221 ATP binding site [chemical binding]; other site 441620010222 Q-loop/lid; other site 441620010223 ABC transporter signature motif; other site 441620010224 Walker B; other site 441620010225 D-loop; other site 441620010226 H-loop/switch region; other site 441620010227 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 441620010228 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441620010229 Walker A/P-loop; other site 441620010230 ATP binding site [chemical binding]; other site 441620010231 Q-loop/lid; other site 441620010232 ABC transporter signature motif; other site 441620010233 Walker B; other site 441620010234 D-loop; other site 441620010235 H-loop/switch region; other site 441620010236 glutathionine S-transferase; Provisional; Region: PRK10542 441620010237 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 441620010238 C-terminal domain interface [polypeptide binding]; other site 441620010239 GSH binding site (G-site) [chemical binding]; other site 441620010240 dimer interface [polypeptide binding]; other site 441620010241 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 441620010242 dimer interface [polypeptide binding]; other site 441620010243 N-terminal domain interface [polypeptide binding]; other site 441620010244 substrate binding pocket (H-site) [chemical binding]; other site 441620010245 Predicted transcriptional regulators [Transcription]; Region: COG1733 441620010246 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 441620010247 Transposase; Region: HTH_Tnp_1; pfam01527 441620010248 putative transposase OrfB; Reviewed; Region: PHA02517 441620010249 HTH-like domain; Region: HTH_21; pfam13276 441620010250 Integrase core domain; Region: rve; pfam00665 441620010251 Integrase core domain; Region: rve_3; pfam13683 441620010252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441620010253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441620010254 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 441620010255 Uncharacterized conserved protein [Function unknown]; Region: COG2128 441620010256 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 441620010257 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 441620010258 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 441620010259 putative C-terminal domain interface [polypeptide binding]; other site 441620010260 putative GSH binding site (G-site) [chemical binding]; other site 441620010261 putative dimer interface [polypeptide binding]; other site 441620010262 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 441620010263 N-terminal domain interface [polypeptide binding]; other site 441620010264 dimer interface [polypeptide binding]; other site 441620010265 substrate binding pocket (H-site) [chemical binding]; other site 441620010266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 441620010267 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 441620010268 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 441620010269 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 441620010270 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 441620010271 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 441620010272 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 441620010273 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441620010274 dimerization interface [polypeptide binding]; other site 441620010275 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620010276 Histidine kinase; Region: HisKA_3; pfam07730 441620010277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620010278 ATP binding site [chemical binding]; other site 441620010279 Mg2+ binding site [ion binding]; other site 441620010280 G-X-G motif; other site 441620010281 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441620010282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620010283 active site 441620010284 phosphorylation site [posttranslational modification] 441620010285 intermolecular recognition site; other site 441620010286 dimerization interface [polypeptide binding]; other site 441620010287 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441620010288 DNA binding residues [nucleotide binding] 441620010289 dimerization interface [polypeptide binding]; other site 441620010290 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441620010291 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441620010292 ligand binding site [chemical binding]; other site 441620010293 flexible hinge region; other site 441620010294 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 441620010295 putative switch regulator; other site 441620010296 non-specific DNA interactions [nucleotide binding]; other site 441620010297 DNA binding site [nucleotide binding] 441620010298 sequence specific DNA binding site [nucleotide binding]; other site 441620010299 putative cAMP binding site [chemical binding]; other site 441620010300 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441620010301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620010302 non-specific DNA binding site [nucleotide binding]; other site 441620010303 salt bridge; other site 441620010304 sequence-specific DNA binding site [nucleotide binding]; other site 441620010305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620010306 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 441620010307 Walker A motif; other site 441620010308 ATP binding site [chemical binding]; other site 441620010309 Walker B motif; other site 441620010310 arginine finger; other site 441620010311 Peptidase family M41; Region: Peptidase_M41; pfam01434 441620010312 Transposase; Region: HTH_Tnp_1; pfam01527 441620010313 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 441620010314 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 441620010315 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 441620010316 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 441620010317 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 441620010318 catalytic residues [active] 441620010319 catalytic nucleophile [active] 441620010320 Recombinase; Region: Recombinase; pfam07508 441620010321 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 441620010322 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 441620010323 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 441620010324 catalytic residues [active] 441620010325 catalytic nucleophile [active] 441620010326 Recombinase; Region: Recombinase; pfam07508 441620010327 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 441620010328 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 441620010329 Protein of unknown function (DUF433); Region: DUF433; pfam04255 441620010330 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 441620010331 oligomeric interface; other site 441620010332 homodimer interface [polypeptide binding]; other site 441620010333 putative active site [active] 441620010334 Helix-turn-helix domain; Region: HTH_17; pfam12728 441620010335 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441620010336 active site 441620010337 Int/Topo IB signature motif; other site 441620010338 DNA binding site [nucleotide binding] 441620010339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441620010340 binding surface 441620010341 Tetratricopeptide repeat; Region: TPR_16; pfam13432 441620010342 TPR motif; other site 441620010343 TPR repeat; Region: TPR_11; pfam13414 441620010344 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441620010345 TPR motif; other site 441620010346 binding surface 441620010347 TPR repeat; Region: TPR_11; pfam13414 441620010348 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 441620010349 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 441620010350 inhibitor-cofactor binding pocket; inhibition site 441620010351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620010352 catalytic residue [active] 441620010353 Methyltransferase domain; Region: Methyltransf_23; pfam13489 441620010354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620010355 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 441620010356 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441620010357 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 441620010358 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 441620010359 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441620010360 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441620010361 ligand binding site [chemical binding]; other site 441620010362 flexible hinge region; other site 441620010363 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 441620010364 putative switch regulator; other site 441620010365 non-specific DNA interactions [nucleotide binding]; other site 441620010366 DNA binding site [nucleotide binding] 441620010367 sequence specific DNA binding site [nucleotide binding]; other site 441620010368 putative cAMP binding site [chemical binding]; other site 441620010369 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 441620010370 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 441620010371 OsmC-like protein; Region: OsmC; pfam02566 441620010372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 441620010373 NMT1-like family; Region: NMT1_2; pfam13379 441620010374 NMT1/THI5 like; Region: NMT1; pfam09084 441620010375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620010376 Walker A/P-loop; other site 441620010377 ATP binding site [chemical binding]; other site 441620010378 ABC transporter; Region: ABC_tran; pfam00005 441620010379 Q-loop/lid; other site 441620010380 ABC transporter signature motif; other site 441620010381 Walker B; other site 441620010382 D-loop; other site 441620010383 H-loop/switch region; other site 441620010384 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 441620010385 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 441620010386 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 441620010387 active site 441620010388 non-prolyl cis peptide bond; other site 441620010389 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 441620010390 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 441620010391 Walker A/P-loop; other site 441620010392 ATP binding site [chemical binding]; other site 441620010393 Q-loop/lid; other site 441620010394 ABC transporter signature motif; other site 441620010395 Walker B; other site 441620010396 D-loop; other site 441620010397 H-loop/switch region; other site 441620010398 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 441620010399 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 441620010400 TM-ABC transporter signature motif; other site 441620010401 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 441620010402 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 441620010403 TM-ABC transporter signature motif; other site 441620010404 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 441620010405 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 441620010406 putative ligand binding site [chemical binding]; other site 441620010407 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 441620010408 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 441620010409 Walker A/P-loop; other site 441620010410 ATP binding site [chemical binding]; other site 441620010411 Q-loop/lid; other site 441620010412 ABC transporter signature motif; other site 441620010413 Walker B; other site 441620010414 D-loop; other site 441620010415 H-loop/switch region; other site 441620010416 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 441620010417 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 441620010418 active site 441620010419 flagellin; Reviewed; Region: PRK12688 441620010420 flagellin; Reviewed; Region: PRK12688 441620010421 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 441620010422 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441620010423 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 441620010424 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 441620010425 putative dimer interface [polypeptide binding]; other site 441620010426 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 441620010427 Ligand Binding Site [chemical binding]; other site 441620010428 Protein required for attachment to host cells; Region: Host_attach; pfam10116 441620010429 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 441620010430 Ligand Binding Site [chemical binding]; other site 441620010431 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 441620010432 BON domain; Region: BON; pfam04972 441620010433 BON domain; Region: BON; pfam04972 441620010434 BON domain; Region: BON; pfam04972 441620010435 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 441620010436 Ligand Binding Site [chemical binding]; other site 441620010437 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441620010438 ligand binding site [chemical binding]; other site 441620010439 flexible hinge region; other site 441620010440 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 441620010441 putative switch regulator; other site 441620010442 non-specific DNA interactions [nucleotide binding]; other site 441620010443 DNA binding site [nucleotide binding] 441620010444 sequence specific DNA binding site [nucleotide binding]; other site 441620010445 putative cAMP binding site [chemical binding]; other site 441620010446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620010447 active site 441620010448 phosphorylation site [posttranslational modification] 441620010449 intermolecular recognition site; other site 441620010450 response regulator FixJ; Provisional; Region: fixJ; PRK09390 441620010451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620010452 active site 441620010453 phosphorylation site [posttranslational modification] 441620010454 intermolecular recognition site; other site 441620010455 dimerization interface [polypeptide binding]; other site 441620010456 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441620010457 DNA binding residues [nucleotide binding] 441620010458 dimerization interface [polypeptide binding]; other site 441620010459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620010460 PAS fold; Region: PAS_3; pfam08447 441620010461 putative active site [active] 441620010462 heme pocket [chemical binding]; other site 441620010463 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 441620010464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620010465 putative active site [active] 441620010466 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620010467 dimer interface [polypeptide binding]; other site 441620010468 phosphorylation site [posttranslational modification] 441620010469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620010470 ATP binding site [chemical binding]; other site 441620010471 Mg2+ binding site [ion binding]; other site 441620010472 G-X-G motif; other site 441620010473 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 441620010474 Ligand Binding Site [chemical binding]; other site 441620010475 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 441620010476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620010477 active site 441620010478 phosphorylation site [posttranslational modification] 441620010479 intermolecular recognition site; other site 441620010480 dimerization interface [polypeptide binding]; other site 441620010481 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441620010482 Zn2+ binding site [ion binding]; other site 441620010483 Mg2+ binding site [ion binding]; other site 441620010484 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441620010485 dimerization interface [polypeptide binding]; other site 441620010486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620010487 dimer interface [polypeptide binding]; other site 441620010488 phosphorylation site [posttranslational modification] 441620010489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620010490 ATP binding site [chemical binding]; other site 441620010491 Mg2+ binding site [ion binding]; other site 441620010492 G-X-G motif; other site 441620010493 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620010494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620010495 active site 441620010496 phosphorylation site [posttranslational modification] 441620010497 intermolecular recognition site; other site 441620010498 dimerization interface [polypeptide binding]; other site 441620010499 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 441620010500 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 441620010501 allophanate hydrolase; Provisional; Region: PRK08186 441620010502 Amidase; Region: Amidase; cl11426 441620010503 urea carboxylase; Region: urea_carbox; TIGR02712 441620010504 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 441620010505 ATP-grasp domain; Region: ATP-grasp_4; cl17255 441620010506 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 441620010507 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 441620010508 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 441620010509 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 441620010510 carboxyltransferase (CT) interaction site; other site 441620010511 biotinylation site [posttranslational modification]; other site 441620010512 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 441620010513 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 441620010514 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 441620010515 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 441620010516 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 441620010517 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 441620010518 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 441620010519 Creatinine amidohydrolase; Region: Creatininase; pfam02633 441620010520 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441620010521 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441620010522 Walker A/P-loop; other site 441620010523 ATP binding site [chemical binding]; other site 441620010524 Q-loop/lid; other site 441620010525 ABC transporter signature motif; other site 441620010526 Walker B; other site 441620010527 D-loop; other site 441620010528 H-loop/switch region; other site 441620010529 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 441620010530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620010531 dimer interface [polypeptide binding]; other site 441620010532 conserved gate region; other site 441620010533 putative PBP binding loops; other site 441620010534 ABC-ATPase subunit interface; other site 441620010535 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 441620010536 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 441620010537 short chain dehydrogenase; Provisional; Region: PRK06197 441620010538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620010539 NAD(P) binding site [chemical binding]; other site 441620010540 active site 441620010541 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 441620010542 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 441620010543 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 441620010544 Uncharacterized conserved protein [Function unknown]; Region: COG3791 441620010545 GAF domain; Region: GAF; cl17456 441620010546 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 441620010547 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 441620010548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620010549 putative PBP binding loops; other site 441620010550 ABC-ATPase subunit interface; other site 441620010551 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 441620010552 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 441620010553 putative C-terminal domain interface [polypeptide binding]; other site 441620010554 putative GSH binding site (G-site) [chemical binding]; other site 441620010555 putative dimer interface [polypeptide binding]; other site 441620010556 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 441620010557 putative N-terminal domain interface [polypeptide binding]; other site 441620010558 putative dimer interface [polypeptide binding]; other site 441620010559 putative substrate binding pocket (H-site) [chemical binding]; other site 441620010560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620010561 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 441620010562 Walker A/P-loop; other site 441620010563 ATP binding site [chemical binding]; other site 441620010564 Q-loop/lid; other site 441620010565 ABC transporter signature motif; other site 441620010566 Walker B; other site 441620010567 D-loop; other site 441620010568 H-loop/switch region; other site 441620010569 TOBE domain; Region: TOBE; cl01440 441620010570 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441620010571 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 441620010572 DNA binding residues [nucleotide binding] 441620010573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 441620010574 Anti-sigma-K factor rskA; Region: RskA; pfam10099 441620010575 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 441620010576 Fasciclin domain; Region: Fasciclin; pfam02469 441620010577 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 441620010578 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 441620010579 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 441620010580 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 441620010581 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 441620010582 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 441620010583 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 441620010584 Sulfate transporter family; Region: Sulfate_transp; pfam00916 441620010585 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 441620010586 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 441620010587 cyclase homology domain; Region: CHD; cd07302 441620010588 nucleotidyl binding site; other site 441620010589 metal binding site [ion binding]; metal-binding site 441620010590 dimer interface [polypeptide binding]; other site 441620010591 LrgB-like family; Region: LrgB; pfam04172 441620010592 LrgA family; Region: LrgA; pfam03788 441620010593 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 441620010594 putative metal binding site [ion binding]; other site 441620010595 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 441620010596 OstA-like protein; Region: OstA; cl00844 441620010597 Organic solvent tolerance protein; Region: OstA_C; pfam04453 441620010598 Predicted permeases [General function prediction only]; Region: COG0795 441620010599 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 441620010600 Predicted permeases [General function prediction only]; Region: COG0795 441620010601 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 441620010602 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 441620010603 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 441620010604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620010605 non-specific DNA binding site [nucleotide binding]; other site 441620010606 salt bridge; other site 441620010607 sequence-specific DNA binding site [nucleotide binding]; other site 441620010608 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 441620010609 multifunctional aminopeptidase A; Provisional; Region: PRK00913 441620010610 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 441620010611 interface (dimer of trimers) [polypeptide binding]; other site 441620010612 Substrate-binding/catalytic site; other site 441620010613 Zn-binding sites [ion binding]; other site 441620010614 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 441620010615 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441620010616 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 441620010617 acyl-activating enzyme (AAE) consensus motif; other site 441620010618 putative AMP binding site [chemical binding]; other site 441620010619 putative active site [active] 441620010620 putative CoA binding site [chemical binding]; other site 441620010621 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 441620010622 Mechanosensitive ion channel; Region: MS_channel; pfam00924 441620010623 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 441620010624 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 441620010625 catalytic residues [active] 441620010626 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 441620010627 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441620010628 Zn2+ binding site [ion binding]; other site 441620010629 Mg2+ binding site [ion binding]; other site 441620010630 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 441620010631 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 441620010632 hypothetical protein; Provisional; Region: PRK08960 441620010633 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441620010634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620010635 homodimer interface [polypeptide binding]; other site 441620010636 catalytic residue [active] 441620010637 Protein of unknown function (DUF422); Region: DUF422; cl00991 441620010638 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 441620010639 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 441620010640 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 441620010641 AMIN domain; Region: AMIN; pfam11741 441620010642 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 441620010643 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 441620010644 active site 441620010645 metal binding site [ion binding]; metal-binding site 441620010646 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 441620010647 Transglycosylase; Region: Transgly; pfam00912 441620010648 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 441620010649 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 441620010650 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 441620010651 active site 441620010652 dimer interface [polypeptide binding]; other site 441620010653 non-prolyl cis peptide bond; other site 441620010654 insertion regions; other site 441620010655 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 441620010656 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 441620010657 Flavin binding site [chemical binding]; other site 441620010658 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 441620010659 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 441620010660 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441620010661 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 441620010662 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 441620010663 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 441620010664 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441620010665 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441620010666 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 441620010667 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 441620010668 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 441620010669 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 441620010670 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 441620010671 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 441620010672 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 441620010673 Ligand binding site; other site 441620010674 DXD motif; other site 441620010675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 441620010676 Transposase; Region: DEDD_Tnp_IS110; pfam01548 441620010677 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620010678 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 441620010679 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 441620010680 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 441620010681 active site 441620010682 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620010683 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 441620010684 putative ADP-binding pocket [chemical binding]; other site 441620010685 Methyltransferase domain; Region: Methyltransf_31; pfam13847 441620010686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620010687 S-adenosylmethionine binding site [chemical binding]; other site 441620010688 Transposase, Mutator family; Region: Transposase_mut; pfam00872 441620010689 MULE transposase domain; Region: MULE; pfam10551 441620010690 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 441620010691 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 441620010692 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 441620010693 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 441620010694 DDE superfamily endonuclease; Region: DDE_5; pfam13546 441620010695 Transposase; Region: HTH_Tnp_1; pfam01527 441620010696 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 441620010697 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 441620010698 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 441620010699 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 441620010700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620010701 S-adenosylmethionine binding site [chemical binding]; other site 441620010702 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 441620010703 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 441620010704 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 441620010705 Protein of unknown function (DUF3768); Region: DUF3768; pfam12599 441620010706 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 441620010707 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 441620010708 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 441620010709 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 441620010710 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 441620010711 conserved cys residue [active] 441620010712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441620010713 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 441620010714 hydroxyglutarate oxidase; Provisional; Region: PRK11728 441620010715 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 441620010716 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 441620010717 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 441620010718 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 441620010719 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 441620010720 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 441620010721 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 441620010722 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 441620010723 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 441620010724 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 441620010725 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 441620010726 putative deacylase active site [active] 441620010727 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 441620010728 Electron transfer flavoprotein domain; Region: ETF; pfam01012 441620010729 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 441620010730 Electron transfer flavoprotein domain; Region: ETF; smart00893 441620010731 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 441620010732 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 441620010733 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 441620010734 4Fe-4S binding domain; Region: Fer4; cl02805 441620010735 Cysteine-rich domain; Region: CCG; pfam02754 441620010736 Cysteine-rich domain; Region: CCG; pfam02754 441620010737 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 441620010738 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 441620010739 putative active site [active] 441620010740 putative FMN binding site [chemical binding]; other site 441620010741 putative substrate binding site [chemical binding]; other site 441620010742 putative catalytic residue [active] 441620010743 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 441620010744 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 441620010745 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 441620010746 FAD binding pocket [chemical binding]; other site 441620010747 FAD binding motif [chemical binding]; other site 441620010748 phosphate binding motif [ion binding]; other site 441620010749 beta-alpha-beta structure motif; other site 441620010750 NAD binding pocket [chemical binding]; other site 441620010751 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441620010752 catalytic loop [active] 441620010753 iron binding site [ion binding]; other site 441620010754 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 441620010755 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 441620010756 [2Fe-2S] cluster binding site [ion binding]; other site 441620010757 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 441620010758 putative alpha subunit interface [polypeptide binding]; other site 441620010759 putative active site [active] 441620010760 putative substrate binding site [chemical binding]; other site 441620010761 Fe binding site [ion binding]; other site 441620010762 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 441620010763 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 441620010764 active site 441620010765 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 441620010766 Phosphotransferase enzyme family; Region: APH; pfam01636 441620010767 active site 441620010768 ATP binding site [chemical binding]; other site 441620010769 substrate binding site [chemical binding]; other site 441620010770 dimer interface [polypeptide binding]; other site 441620010771 Phosphotransferase enzyme family; Region: APH; pfam01636 441620010772 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 441620010773 substrate binding site [chemical binding]; other site 441620010774 allantoate amidohydrolase; Reviewed; Region: PRK09290 441620010775 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 441620010776 active site 441620010777 metal binding site [ion binding]; metal-binding site 441620010778 dimer interface [polypeptide binding]; other site 441620010779 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 441620010780 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 441620010781 putative switch regulator; other site 441620010782 non-specific DNA interactions [nucleotide binding]; other site 441620010783 DNA binding site [nucleotide binding] 441620010784 sequence specific DNA binding site [nucleotide binding]; other site 441620010785 putative cAMP binding site [chemical binding]; other site 441620010786 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 441620010787 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 441620010788 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441620010789 Walker A/P-loop; other site 441620010790 ATP binding site [chemical binding]; other site 441620010791 Q-loop/lid; other site 441620010792 ABC transporter signature motif; other site 441620010793 Walker B; other site 441620010794 D-loop; other site 441620010795 H-loop/switch region; other site 441620010796 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 441620010797 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441620010798 Walker A/P-loop; other site 441620010799 ATP binding site [chemical binding]; other site 441620010800 Q-loop/lid; other site 441620010801 ABC transporter signature motif; other site 441620010802 Walker B; other site 441620010803 D-loop; other site 441620010804 H-loop/switch region; other site 441620010805 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 441620010806 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 441620010807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620010808 dimer interface [polypeptide binding]; other site 441620010809 conserved gate region; other site 441620010810 putative PBP binding loops; other site 441620010811 ABC-ATPase subunit interface; other site 441620010812 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 441620010813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620010814 dimer interface [polypeptide binding]; other site 441620010815 conserved gate region; other site 441620010816 putative PBP binding loops; other site 441620010817 ABC-ATPase subunit interface; other site 441620010818 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 441620010819 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 441620010820 Secretin and TonB N terminus short domain; Region: STN; smart00965 441620010821 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 441620010822 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620010823 N-terminal plug; other site 441620010824 ligand-binding site [chemical binding]; other site 441620010825 FecR protein; Region: FecR; pfam04773 441620010826 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 441620010827 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 441620010828 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441620010829 DNA binding residues [nucleotide binding] 441620010830 IucA / IucC family; Region: IucA_IucC; pfam04183 441620010831 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 441620010832 IucA / IucC family; Region: IucA_IucC; pfam04183 441620010833 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 441620010834 acyl-CoA synthetase; Validated; Region: PRK08308 441620010835 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441620010836 acyl-activating enzyme (AAE) consensus motif; other site 441620010837 AMP binding site [chemical binding]; other site 441620010838 active site 441620010839 CoA binding site [chemical binding]; other site 441620010840 acyl carrier protein; Provisional; Region: PRK07639 441620010841 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 441620010842 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441620010843 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 441620010844 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 441620010845 putative acetyltransferase YhhY; Provisional; Region: PRK10140 441620010846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441620010847 Coenzyme A binding pocket [chemical binding]; other site 441620010848 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 441620010849 TetR family transcriptional regulator; Provisional; Region: PRK14996 441620010850 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 441620010851 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 441620010852 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 441620010853 Membrane fusogenic activity; Region: BMFP; pfam04380 441620010854 osmolarity response regulator; Provisional; Region: ompR; PRK09468 441620010855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620010856 active site 441620010857 phosphorylation site [posttranslational modification] 441620010858 intermolecular recognition site; other site 441620010859 dimerization interface [polypeptide binding]; other site 441620010860 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620010861 DNA binding site [nucleotide binding] 441620010862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620010863 dimer interface [polypeptide binding]; other site 441620010864 phosphorylation site [posttranslational modification] 441620010865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620010866 ATP binding site [chemical binding]; other site 441620010867 Mg2+ binding site [ion binding]; other site 441620010868 G-X-G motif; other site 441620010869 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620010870 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620010871 metal binding site [ion binding]; metal-binding site 441620010872 active site 441620010873 I-site; other site 441620010874 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 441620010875 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 441620010876 putative C-terminal domain interface [polypeptide binding]; other site 441620010877 putative GSH binding site (G-site) [chemical binding]; other site 441620010878 putative dimer interface [polypeptide binding]; other site 441620010879 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 441620010880 putative N-terminal domain interface [polypeptide binding]; other site 441620010881 putative substrate binding pocket (H-site) [chemical binding]; other site 441620010882 Transposase, Mutator family; Region: Transposase_mut; pfam00872 441620010883 MULE transposase domain; Region: MULE; pfam10551 441620010884 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 441620010885 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 441620010886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620010887 active site 441620010888 phosphorylation site [posttranslational modification] 441620010889 intermolecular recognition site; other site 441620010890 dimerization interface [polypeptide binding]; other site 441620010891 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 441620010892 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 441620010893 putative active site [active] 441620010894 putative dimer interface [polypeptide binding]; other site 441620010895 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441620010896 hypothetical protein; Provisional; Region: PRK10621 441620010897 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 441620010898 putative active site [active] 441620010899 putative catalytic site [active] 441620010900 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 441620010901 putative active site [active] 441620010902 putative catalytic site [active] 441620010903 YGGT family; Region: YGGT; pfam02325 441620010904 FRG domain; Region: FRG; pfam08867 441620010905 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 441620010906 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 441620010907 ATP binding site [chemical binding]; other site 441620010908 substrate binding site [chemical binding]; other site 441620010909 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 441620010910 Ligand Binding Site [chemical binding]; other site 441620010911 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 441620010912 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 441620010913 helix-hairpin-helix signature motif; other site 441620010914 active site 441620010915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620010916 non-specific DNA binding site [nucleotide binding]; other site 441620010917 salt bridge; other site 441620010918 sequence-specific DNA binding site [nucleotide binding]; other site 441620010919 PemK-like protein; Region: PemK; pfam02452 441620010920 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441620010921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620010922 putative substrate translocation pore; other site 441620010923 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 441620010924 Sodium Bile acid symporter family; Region: SBF; cl17470 441620010925 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 441620010926 ArsC family; Region: ArsC; pfam03960 441620010927 catalytic residues [active] 441620010928 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 441620010929 Low molecular weight phosphatase family; Region: LMWPc; cd00115 441620010930 active site 441620010931 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441620010932 dimerization interface [polypeptide binding]; other site 441620010933 putative DNA binding site [nucleotide binding]; other site 441620010934 putative Zn2+ binding site [ion binding]; other site 441620010935 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 441620010936 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 441620010937 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 441620010938 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 441620010939 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 441620010940 Predicted membrane protein [Function unknown]; Region: COG2510 441620010941 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 441620010942 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 441620010943 catalytic residues [active] 441620010944 catalytic nucleophile [active] 441620010945 Recombinase; Region: Recombinase; pfam07508 441620010946 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 441620010947 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 441620010948 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 441620010949 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 441620010950 active site 441620010951 metal binding site [ion binding]; metal-binding site 441620010952 Transposase, Mutator family; Region: Transposase_mut; pfam00872 441620010953 MULE transposase domain; Region: MULE; pfam10551 441620010954 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 441620010955 DNA binding residues [nucleotide binding] 441620010956 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 441620010957 dimer interface [polypeptide binding]; other site 441620010958 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441620010959 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 441620010960 metal-binding site [ion binding] 441620010961 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 441620010962 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441620010963 Soluble P-type ATPase [General function prediction only]; Region: COG4087 441620010964 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 441620010965 DNA binding residues [nucleotide binding] 441620010966 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 441620010967 dimer interface [polypeptide binding]; other site 441620010968 putative metal binding site [ion binding]; other site 441620010969 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 441620010970 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 441620010971 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441620010972 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441620010973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620010974 active site 441620010975 phosphorylation site [posttranslational modification] 441620010976 intermolecular recognition site; other site 441620010977 dimerization interface [polypeptide binding]; other site 441620010978 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620010979 DNA binding site [nucleotide binding] 441620010980 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441620010981 dimerization interface [polypeptide binding]; other site 441620010982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620010983 ATP binding site [chemical binding]; other site 441620010984 Mg2+ binding site [ion binding]; other site 441620010985 G-X-G motif; other site 441620010986 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 441620010987 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 441620010988 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620010989 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 441620010990 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 441620010991 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 441620010992 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 441620010993 Protein export membrane protein; Region: SecD_SecF; cl14618 441620010994 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441620010995 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620010996 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 441620010997 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 441620010998 Fic/DOC family; Region: Fic; pfam02661 441620010999 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441620011000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620011001 active site 441620011002 phosphorylation site [posttranslational modification] 441620011003 intermolecular recognition site; other site 441620011004 dimerization interface [polypeptide binding]; other site 441620011005 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620011006 DNA binding site [nucleotide binding] 441620011007 sensor protein QseC; Provisional; Region: PRK10337 441620011008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620011009 dimer interface [polypeptide binding]; other site 441620011010 phosphorylation site [posttranslational modification] 441620011011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620011012 ATP binding site [chemical binding]; other site 441620011013 Mg2+ binding site [ion binding]; other site 441620011014 G-X-G motif; other site 441620011015 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 441620011016 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 441620011017 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 441620011018 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 441620011019 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 441620011020 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 441620011021 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 441620011022 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 441620011023 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 441620011024 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 441620011025 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 441620011026 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 441620011027 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 441620011028 active site 441620011029 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620011030 PAS domain; Region: PAS_9; pfam13426 441620011031 putative active site [active] 441620011032 heme pocket [chemical binding]; other site 441620011033 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620011034 PAS fold; Region: PAS_3; pfam08447 441620011035 putative active site [active] 441620011036 heme pocket [chemical binding]; other site 441620011037 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620011038 GAF domain; Region: GAF; pfam01590 441620011039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620011040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620011041 dimer interface [polypeptide binding]; other site 441620011042 phosphorylation site [posttranslational modification] 441620011043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620011044 ATP binding site [chemical binding]; other site 441620011045 Mg2+ binding site [ion binding]; other site 441620011046 G-X-G motif; other site 441620011047 Response regulator receiver domain; Region: Response_reg; pfam00072 441620011048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620011049 active site 441620011050 phosphorylation site [posttranslational modification] 441620011051 intermolecular recognition site; other site 441620011052 dimerization interface [polypeptide binding]; other site 441620011053 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 441620011054 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620011055 putative active site [active] 441620011056 heme pocket [chemical binding]; other site 441620011057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620011058 Histidine kinase; Region: HisKA_2; pfam07568 441620011059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620011060 ATP binding site [chemical binding]; other site 441620011061 Mg2+ binding site [ion binding]; other site 441620011062 G-X-G motif; other site 441620011063 PAS fold; Region: PAS_4; pfam08448 441620011064 PAS fold; Region: PAS_4; pfam08448 441620011065 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620011066 GAF domain; Region: GAF; pfam01590 441620011067 PAS domain; Region: PAS_9; pfam13426 441620011068 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620011069 putative active site [active] 441620011070 heme pocket [chemical binding]; other site 441620011071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620011072 PAS domain; Region: PAS_9; pfam13426 441620011073 putative active site [active] 441620011074 heme pocket [chemical binding]; other site 441620011075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620011076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620011077 dimer interface [polypeptide binding]; other site 441620011078 phosphorylation site [posttranslational modification] 441620011079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620011080 ATP binding site [chemical binding]; other site 441620011081 Mg2+ binding site [ion binding]; other site 441620011082 G-X-G motif; other site 441620011083 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620011084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620011085 active site 441620011086 phosphorylation site [posttranslational modification] 441620011087 intermolecular recognition site; other site 441620011088 dimerization interface [polypeptide binding]; other site 441620011089 YtkA-like; Region: YtkA; pfam13115 441620011090 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 441620011091 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620011092 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 441620011093 Protein of unknown function, DUF; Region: DUF411; cl01142 441620011094 LabA_like proteins; Region: LabA_like; cd06167 441620011095 putative metal binding site [ion binding]; other site 441620011096 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 441620011097 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 441620011098 DNA binding residues [nucleotide binding] 441620011099 dimer interface [polypeptide binding]; other site 441620011100 putative metal binding site [ion binding]; other site 441620011101 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 441620011102 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441620011103 metal-binding site [ion binding] 441620011104 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441620011105 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 441620011106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 441620011107 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 441620011108 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 441620011109 hypothetical protein; Provisional; Region: PRK02237 441620011110 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 441620011111 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620011112 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 441620011113 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620011114 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 441620011115 Protein export membrane protein; Region: SecD_SecF; cl14618 441620011116 Domain of unknown function (DUF305); Region: DUF305; cl17794 441620011117 YHS domain; Region: YHS; pfam04945 441620011118 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 441620011119 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441620011120 Soluble P-type ATPase [General function prediction only]; Region: COG4087 441620011121 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 441620011122 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 441620011123 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 441620011124 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 441620011125 ATP binding site [chemical binding]; other site 441620011126 substrate interface [chemical binding]; other site 441620011127 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 441620011128 Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462 441620011129 Domain of unknown function (DUF955); Region: DUF955; pfam06114 441620011130 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 441620011131 Part of AAA domain; Region: AAA_19; pfam13245 441620011132 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 441620011133 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 441620011134 DNA binding residues [nucleotide binding] 441620011135 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441620011136 putative Zn2+ binding site [ion binding]; other site 441620011137 putative DNA binding site [nucleotide binding]; other site 441620011138 sensor protein QseC; Provisional; Region: PRK10337 441620011139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620011140 dimer interface [polypeptide binding]; other site 441620011141 phosphorylation site [posttranslational modification] 441620011142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620011143 ATP binding site [chemical binding]; other site 441620011144 Mg2+ binding site [ion binding]; other site 441620011145 G-X-G motif; other site 441620011146 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 441620011147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620011148 active site 441620011149 phosphorylation site [posttranslational modification] 441620011150 intermolecular recognition site; other site 441620011151 dimerization interface [polypeptide binding]; other site 441620011152 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620011153 DNA binding site [nucleotide binding] 441620011154 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 441620011155 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 441620011156 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441620011157 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 441620011158 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 441620011159 catalytic residues [active] 441620011160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 441620011161 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441620011162 DsrE/DsrF-like family; Region: DrsE; cl00672 441620011163 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 441620011164 Predicted transporter component [General function prediction only]; Region: COG2391 441620011165 Predicted transporter component [General function prediction only]; Region: COG2391 441620011166 Sulphur transport; Region: Sulf_transp; pfam04143 441620011167 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 441620011168 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 441620011169 active site residue [active] 441620011170 RNA polymerase sigma factor; Provisional; Region: PRK12547 441620011171 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441620011172 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441620011173 DNA binding residues [nucleotide binding] 441620011174 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441620011175 dimerization interface [polypeptide binding]; other site 441620011176 putative DNA binding site [nucleotide binding]; other site 441620011177 putative Zn2+ binding site [ion binding]; other site 441620011178 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 441620011179 catalytic residues [active] 441620011180 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 441620011181 catalytic residues [active] 441620011182 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 441620011183 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 441620011184 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 441620011185 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 441620011186 Cytochrome c [Energy production and conversion]; Region: COG3258 441620011187 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 441620011188 active site 441620011189 metal binding site [ion binding]; metal-binding site 441620011190 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 441620011191 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 441620011192 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 441620011193 Moco binding site; other site 441620011194 metal coordination site [ion binding]; other site 441620011195 dimerization interface [polypeptide binding]; other site 441620011196 Cytochrome c; Region: Cytochrom_C; pfam00034 441620011197 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441620011198 DsrE/DsrF-like family; Region: DrsE; pfam02635 441620011199 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 441620011200 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 441620011201 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 441620011202 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 441620011203 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 441620011204 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 441620011205 DPS ferroxidase diiron center [ion binding]; other site 441620011206 dimerization interface [polypeptide binding]; other site 441620011207 ion pore; other site 441620011208 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441620011209 active site 441620011210 DNA binding site [nucleotide binding] 441620011211 Int/Topo IB signature motif; other site 441620011212 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 441620011213 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 441620011214 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441620011215 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620011216 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441620011217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441620011218 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 441620011219 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 441620011220 Transposase, Mutator family; Region: Transposase_mut; pfam00872 441620011221 MULE transposase domain; Region: MULE; pfam10551 441620011222 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 441620011223 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 441620011224 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441620011225 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441620011226 Walker A/P-loop; other site 441620011227 ATP binding site [chemical binding]; other site 441620011228 Q-loop/lid; other site 441620011229 ABC transporter signature motif; other site 441620011230 Walker B; other site 441620011231 D-loop; other site 441620011232 H-loop/switch region; other site 441620011233 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 441620011234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620011235 dimer interface [polypeptide binding]; other site 441620011236 conserved gate region; other site 441620011237 putative PBP binding loops; other site 441620011238 ABC-ATPase subunit interface; other site 441620011239 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 441620011240 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441620011241 substrate binding pocket [chemical binding]; other site 441620011242 membrane-bound complex binding site; other site 441620011243 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441620011244 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441620011245 ligand binding site [chemical binding]; other site 441620011246 flexible hinge region; other site 441620011247 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 441620011248 putative switch regulator; other site 441620011249 non-specific DNA interactions [nucleotide binding]; other site 441620011250 DNA binding site [nucleotide binding] 441620011251 sequence specific DNA binding site [nucleotide binding]; other site 441620011252 putative cAMP binding site [chemical binding]; other site 441620011253 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 441620011254 HEAT repeats; Region: HEAT_2; pfam13646 441620011255 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 441620011256 HEAT repeats; Region: HEAT_2; pfam13646 441620011257 protein binding surface [polypeptide binding]; other site 441620011258 HEAT repeats; Region: HEAT_2; pfam13646 441620011259 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 441620011260 putative oxidoreductase; Provisional; Region: PRK08275 441620011261 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 441620011262 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 441620011263 Protein of unknown function (DUF971); Region: DUF971; pfam06155 441620011264 hypothetical protein; Provisional; Region: PRK01254 441620011265 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 441620011266 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 441620011267 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 441620011268 Chromate transporter; Region: Chromate_transp; pfam02417 441620011269 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 441620011270 active site residue [active] 441620011271 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 441620011272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620011273 ATP binding site [chemical binding]; other site 441620011274 Mg2+ binding site [ion binding]; other site 441620011275 G-X-G motif; other site 441620011276 Response regulator receiver domain; Region: Response_reg; pfam00072 441620011277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620011278 active site 441620011279 phosphorylation site [posttranslational modification] 441620011280 intermolecular recognition site; other site 441620011281 dimerization interface [polypeptide binding]; other site 441620011282 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 441620011283 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 441620011284 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 441620011285 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 441620011286 dimerization interface [polypeptide binding]; other site 441620011287 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441620011288 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620011289 dimer interface [polypeptide binding]; other site 441620011290 putative CheW interface [polypeptide binding]; other site 441620011291 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 441620011292 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 441620011293 Cytochrome c; Region: Cytochrom_C; pfam00034 441620011294 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 441620011295 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 441620011296 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 441620011297 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 441620011298 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 441620011299 Major royal jelly protein; Region: MRJP; pfam03022 441620011300 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 441620011301 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 441620011302 active site 441620011303 metal binding site [ion binding]; metal-binding site 441620011304 Transcriptional regulator [Transcription]; Region: IclR; COG1414 441620011305 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 441620011306 Bacterial transcriptional regulator; Region: IclR; pfam01614 441620011307 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 441620011308 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 441620011309 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 441620011310 active site 441620011311 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 441620011312 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 441620011313 PYR/PP interface [polypeptide binding]; other site 441620011314 dimer interface [polypeptide binding]; other site 441620011315 TPP binding site [chemical binding]; other site 441620011316 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 441620011317 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 441620011318 TPP-binding site [chemical binding]; other site 441620011319 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 441620011320 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 441620011321 active site pocket [active] 441620011322 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 441620011323 classical (c) SDRs; Region: SDR_c; cd05233 441620011324 NAD(P) binding site [chemical binding]; other site 441620011325 active site 441620011326 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 441620011327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620011328 putative substrate translocation pore; other site 441620011329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620011330 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 441620011331 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620011332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620011333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 441620011334 dimerization interface [polypeptide binding]; other site 441620011335 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 441620011336 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 441620011337 tetrameric interface [polypeptide binding]; other site 441620011338 NAD binding site [chemical binding]; other site 441620011339 catalytic residues [active] 441620011340 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620011341 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620011342 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 441620011343 putative effector binding pocket; other site 441620011344 dimerization interface [polypeptide binding]; other site 441620011345 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 441620011346 hypothetical protein; Provisional; Region: PRK08204 441620011347 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 441620011348 active site 441620011349 Transposase; Region: HTH_Tnp_1; pfam01527 441620011350 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 441620011351 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 441620011352 Walker A/P-loop; other site 441620011353 ATP binding site [chemical binding]; other site 441620011354 Q-loop/lid; other site 441620011355 ABC transporter signature motif; other site 441620011356 Walker B; other site 441620011357 D-loop; other site 441620011358 H-loop/switch region; other site 441620011359 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 441620011360 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441620011361 ABC-ATPase subunit interface; other site 441620011362 dimer interface [polypeptide binding]; other site 441620011363 putative PBP binding regions; other site 441620011364 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 441620011365 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 441620011366 intersubunit interface [polypeptide binding]; other site 441620011367 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 441620011368 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620011369 N-terminal plug; other site 441620011370 ligand-binding site [chemical binding]; other site 441620011371 Transposase, Mutator family; Region: Transposase_mut; pfam00872 441620011372 MULE transposase domain; Region: MULE; pfam10551 441620011373 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 441620011374 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 441620011375 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 441620011376 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 441620011377 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620011378 N-terminal plug; other site 441620011379 ligand-binding site [chemical binding]; other site 441620011380 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 441620011381 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 441620011382 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441620011383 Sterol carrier protein domain; Region: SCP2_2; pfam13530 441620011384 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 441620011385 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441620011386 TIGR02594 family protein; Region: TIGR02594 441620011387 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 441620011388 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 441620011389 Protein of unknown function (DUF563); Region: DUF563; pfam04577 441620011390 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 441620011391 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 441620011392 Methyltransferase domain; Region: Methyltransf_24; pfam13578 441620011393 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 441620011394 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 441620011395 NAD binding site [chemical binding]; other site 441620011396 substrate binding site [chemical binding]; other site 441620011397 homodimer interface [polypeptide binding]; other site 441620011398 active site 441620011399 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 441620011400 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 441620011401 NADP binding site [chemical binding]; other site 441620011402 active site 441620011403 putative substrate binding site [chemical binding]; other site 441620011404 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 441620011405 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 441620011406 substrate binding site; other site 441620011407 tetramer interface; other site 441620011408 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 441620011409 classical (c) SDRs; Region: SDR_c; cd05233 441620011410 NAD(P) binding site [chemical binding]; other site 441620011411 active site 441620011412 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 441620011413 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 441620011414 G1 box; other site 441620011415 putative GEF interaction site [polypeptide binding]; other site 441620011416 GTP/Mg2+ binding site [chemical binding]; other site 441620011417 Switch I region; other site 441620011418 G2 box; other site 441620011419 G3 box; other site 441620011420 Switch II region; other site 441620011421 G4 box; other site 441620011422 G5 box; other site 441620011423 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 441620011424 tellurium resistance terB-like protein; Region: terB_like; cl11965 441620011425 metal binding site [ion binding]; metal-binding site 441620011426 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441620011427 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441620011428 Walker A/P-loop; other site 441620011429 ATP binding site [chemical binding]; other site 441620011430 Q-loop/lid; other site 441620011431 ABC transporter signature motif; other site 441620011432 Walker B; other site 441620011433 D-loop; other site 441620011434 H-loop/switch region; other site 441620011435 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 441620011436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620011437 dimer interface [polypeptide binding]; other site 441620011438 conserved gate region; other site 441620011439 putative PBP binding loops; other site 441620011440 ABC-ATPase subunit interface; other site 441620011441 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 441620011442 NMT1-like family; Region: NMT1_2; pfam13379 441620011443 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 441620011444 manganese transport regulator MntR; Provisional; Region: PRK11050 441620011445 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 441620011446 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 441620011447 manganese transport protein MntH; Reviewed; Region: PRK00701 441620011448 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 441620011449 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620011450 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 441620011451 putative dimerization interface [polypeptide binding]; other site 441620011452 transmembrane helices; other site 441620011453 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 441620011454 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 441620011455 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 441620011456 Iron-sulfur protein interface; other site 441620011457 proximal quinone binding site [chemical binding]; other site 441620011458 SdhD (CybS) interface [polypeptide binding]; other site 441620011459 proximal heme binding site [chemical binding]; other site 441620011460 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 441620011461 putative SdhC subunit interface [polypeptide binding]; other site 441620011462 putative proximal heme binding site [chemical binding]; other site 441620011463 putative Iron-sulfur protein interface [polypeptide binding]; other site 441620011464 putative proximal quinone binding site; other site 441620011465 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 441620011466 L-aspartate oxidase; Provisional; Region: PRK06175 441620011467 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 441620011468 Uncharacterized conserved protein [Function unknown]; Region: COG2442 441620011469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 441620011470 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 441620011471 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 441620011472 Protease inhibitor Inh; Region: Inh; pfam02974 441620011473 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 441620011474 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 441620011475 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 441620011476 putative active site [active] 441620011477 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 441620011478 Protein of unknown function, DUF606; Region: DUF606; pfam04657 441620011479 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 441620011480 substrate binding site [chemical binding]; other site 441620011481 oxyanion hole (OAH) forming residues; other site 441620011482 trimer interface [polypeptide binding]; other site 441620011483 short chain dehydrogenase; Provisional; Region: PRK08303 441620011484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620011485 NAD(P) binding site [chemical binding]; other site 441620011486 active site 441620011487 short chain dehydrogenase; Provisional; Region: PRK08278 441620011488 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 441620011489 NAD(P) binding site [chemical binding]; other site 441620011490 homodimer interface [polypeptide binding]; other site 441620011491 active site 441620011492 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 441620011493 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 441620011494 Cl binding site [ion binding]; other site 441620011495 oligomer interface [polypeptide binding]; other site 441620011496 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 441620011497 dimerization interface [polypeptide binding]; other site 441620011498 metal binding site [ion binding]; metal-binding site 441620011499 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 441620011500 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 441620011501 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 441620011502 putative metal binding site [ion binding]; other site 441620011503 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 441620011504 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 441620011505 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 441620011506 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441620011507 ABC-ATPase subunit interface; other site 441620011508 dimer interface [polypeptide binding]; other site 441620011509 putative PBP binding regions; other site 441620011510 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 441620011511 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 441620011512 Walker A/P-loop; other site 441620011513 ATP binding site [chemical binding]; other site 441620011514 Q-loop/lid; other site 441620011515 ABC transporter signature motif; other site 441620011516 Walker B; other site 441620011517 D-loop; other site 441620011518 H-loop/switch region; other site 441620011519 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 441620011520 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 441620011521 Moco binding site; other site 441620011522 metal coordination site [ion binding]; other site 441620011523 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 441620011524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441620011525 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 441620011526 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 441620011527 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 441620011528 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 441620011529 active site 441620011530 catalytic tetrad [active] 441620011531 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 441620011532 Predicted transcriptional regulator [Transcription]; Region: COG2944 441620011533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620011534 non-specific DNA binding site [nucleotide binding]; other site 441620011535 salt bridge; other site 441620011536 sequence-specific DNA binding site [nucleotide binding]; other site 441620011537 Isochorismatase family; Region: Isochorismatase; pfam00857 441620011538 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 441620011539 catalytic triad [active] 441620011540 conserved cis-peptide bond; other site 441620011541 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441620011542 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620011543 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 441620011544 TLC ATP/ADP transporter; Region: TLC; cl03940 441620011545 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 441620011546 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 441620011547 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 441620011548 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 441620011549 active site 441620011550 catalytic tetrad [active] 441620011551 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 441620011552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620011553 S-adenosylmethionine binding site [chemical binding]; other site 441620011554 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 441620011555 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441620011556 RNA binding surface [nucleotide binding]; other site 441620011557 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 441620011558 active site 441620011559 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620011560 PAS domain; Region: PAS_9; pfam13426 441620011561 putative active site [active] 441620011562 heme pocket [chemical binding]; other site 441620011563 PAS domain; Region: PAS; smart00091 441620011564 PAS fold; Region: PAS_7; pfam12860 441620011565 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620011566 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620011567 metal binding site [ion binding]; metal-binding site 441620011568 active site 441620011569 I-site; other site 441620011570 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 441620011571 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 441620011572 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620011573 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 441620011574 NAD(P) binding site [chemical binding]; other site 441620011575 active site 441620011576 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 441620011577 nucleoside/Zn binding site; other site 441620011578 dimer interface [polypeptide binding]; other site 441620011579 catalytic motif [active] 441620011580 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 441620011581 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 441620011582 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 441620011583 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 441620011584 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 441620011585 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 441620011586 generic binding surface II; other site 441620011587 generic binding surface I; other site 441620011588 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 441620011589 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 441620011590 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 441620011591 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441620011592 active site 441620011593 transcription elongation factor regulatory protein; Validated; Region: PRK06342 441620011594 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 441620011595 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 441620011596 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 441620011597 NADP binding site [chemical binding]; other site 441620011598 dimer interface [polypeptide binding]; other site 441620011599 Ferredoxin [Energy production and conversion]; Region: COG1146 441620011600 4Fe-4S binding domain; Region: Fer4; pfam00037 441620011601 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 441620011602 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 441620011603 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 441620011604 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441620011605 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441620011606 DNA binding residues [nucleotide binding] 441620011607 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620011608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620011609 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 441620011610 putative effector binding pocket; other site 441620011611 dimerization interface [polypeptide binding]; other site 441620011612 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441620011613 active site 441620011614 Int/Topo IB signature motif; other site 441620011615 DNA binding site [nucleotide binding] 441620011616 Isochorismatase family; Region: Isochorismatase; pfam00857 441620011617 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 441620011618 catalytic triad [active] 441620011619 conserved cis-peptide bond; other site 441620011620 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 441620011621 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 441620011622 TM-ABC transporter signature motif; other site 441620011623 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 441620011624 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 441620011625 TM-ABC transporter signature motif; other site 441620011626 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 441620011627 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 441620011628 Walker A/P-loop; other site 441620011629 ATP binding site [chemical binding]; other site 441620011630 Q-loop/lid; other site 441620011631 ABC transporter signature motif; other site 441620011632 Walker B; other site 441620011633 D-loop; other site 441620011634 H-loop/switch region; other site 441620011635 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 441620011636 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 441620011637 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 441620011638 putative ligand binding site [chemical binding]; other site 441620011639 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 441620011640 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 441620011641 active site 441620011642 metal binding site [ion binding]; metal-binding site 441620011643 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 441620011644 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 441620011645 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 441620011646 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 441620011647 Glucose inhibited division protein A; Region: GIDA; pfam01134 441620011648 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620011649 putative CheW interface [polypeptide binding]; other site 441620011650 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 441620011651 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 441620011652 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 441620011653 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 441620011654 protein binding site [polypeptide binding]; other site 441620011655 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 441620011656 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 441620011657 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 441620011658 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 441620011659 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 441620011660 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 441620011661 Cupin domain; Region: Cupin_2; cl17218 441620011662 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620011663 putative CheW interface [polypeptide binding]; other site 441620011664 Nitrate and nitrite sensing; Region: NIT; pfam08376 441620011665 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620011666 dimer interface [polypeptide binding]; other site 441620011667 putative CheW interface [polypeptide binding]; other site 441620011668 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441620011669 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620011670 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620011671 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 441620011672 Response regulator receiver domain; Region: Response_reg; pfam00072 441620011673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 441620011674 active site 441620011675 phosphorylation site [posttranslational modification] 441620011676 intermolecular recognition site; other site 441620011677 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620011678 GAF domain; Region: GAF; pfam01590 441620011679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620011680 PAS fold; Region: PAS_3; pfam08447 441620011681 putative active site [active] 441620011682 heme pocket [chemical binding]; other site 441620011683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620011684 PAS fold; Region: PAS_3; pfam08447 441620011685 putative active site [active] 441620011686 heme pocket [chemical binding]; other site 441620011687 PAS domain S-box; Region: sensory_box; TIGR00229 441620011688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620011689 putative active site [active] 441620011690 heme pocket [chemical binding]; other site 441620011691 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620011692 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 441620011693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620011694 HWE histidine kinase; Region: HWE_HK; pfam07536 441620011695 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441620011696 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 441620011697 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 441620011698 non-specific DNA interactions [nucleotide binding]; other site 441620011699 DNA binding site [nucleotide binding] 441620011700 sequence specific DNA binding site [nucleotide binding]; other site 441620011701 putative cAMP binding site [chemical binding]; other site 441620011702 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 441620011703 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 441620011704 active site 441620011705 Protein of unknown function, DUF488; Region: DUF488; pfam04343 441620011706 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 441620011707 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 441620011708 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 441620011709 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 441620011710 NADP binding site [chemical binding]; other site 441620011711 dimer interface [polypeptide binding]; other site 441620011712 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 441620011713 Isochorismatase family; Region: Isochorismatase; pfam00857 441620011714 catalytic triad [active] 441620011715 metal binding site [ion binding]; metal-binding site 441620011716 conserved cis-peptide bond; other site 441620011717 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 441620011718 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 441620011719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620011720 catalytic residue [active] 441620011721 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 441620011722 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 441620011723 glutamine binding [chemical binding]; other site 441620011724 catalytic triad [active] 441620011725 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 441620011726 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 441620011727 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 441620011728 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 441620011729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 441620011730 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 441620011731 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 441620011732 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441620011733 FeS/SAM binding site; other site 441620011734 Predicted membrane protein [Function unknown]; Region: COG4270 441620011735 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 441620011736 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 441620011737 homodimer interface [polypeptide binding]; other site 441620011738 metal binding site [ion binding]; metal-binding site 441620011739 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 441620011740 homodimer interface [polypeptide binding]; other site 441620011741 active site 441620011742 putative chemical substrate binding site [chemical binding]; other site 441620011743 metal binding site [ion binding]; metal-binding site 441620011744 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 441620011745 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 441620011746 active site 441620011747 nucleophile elbow; other site 441620011748 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 441620011749 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 441620011750 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620011751 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620011752 metal binding site [ion binding]; metal-binding site 441620011753 active site 441620011754 I-site; other site 441620011755 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441620011756 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620011757 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620011758 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 441620011759 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441620011760 Zn2+ binding site [ion binding]; other site 441620011761 Mg2+ binding site [ion binding]; other site 441620011762 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 441620011763 oligomer interface [polypeptide binding]; other site 441620011764 putative active site [active] 441620011765 Mn binding site [ion binding]; other site 441620011766 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 441620011767 Flavoprotein; Region: Flavoprotein; pfam02441 441620011768 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 441620011769 ABC1 family; Region: ABC1; cl17513 441620011770 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 441620011771 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 441620011772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620011773 S-adenosylmethionine binding site [chemical binding]; other site 441620011774 Protein of unknown function (DUF563); Region: DUF563; pfam04577 441620011775 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 441620011776 folate binding site [chemical binding]; other site 441620011777 NADP+ binding site [chemical binding]; other site 441620011778 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 441620011779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620011780 NAD(P) binding site [chemical binding]; other site 441620011781 active site 441620011782 amidophosphoribosyltransferase; Provisional; Region: PRK09123 441620011783 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 441620011784 active site 441620011785 tetramer interface [polypeptide binding]; other site 441620011786 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441620011787 active site 441620011788 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 441620011789 Colicin V production protein; Region: Colicin_V; pfam02674 441620011790 DNA repair protein RadA; Provisional; Region: PRK11823 441620011791 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 441620011792 Walker A motif/ATP binding site; other site 441620011793 ATP binding site [chemical binding]; other site 441620011794 Walker B motif; other site 441620011795 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 441620011796 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 441620011797 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 441620011798 active site 441620011799 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441620011800 dimer interface [polypeptide binding]; other site 441620011801 substrate binding site [chemical binding]; other site 441620011802 catalytic residues [active] 441620011803 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 441620011804 Domain of unknown function DUF29; Region: DUF29; pfam01724 441620011805 replicative DNA helicase; Provisional; Region: PRK09165 441620011806 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 441620011807 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 441620011808 Walker A motif; other site 441620011809 ATP binding site [chemical binding]; other site 441620011810 Walker B motif; other site 441620011811 DNA binding loops [nucleotide binding] 441620011812 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 441620011813 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 441620011814 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 441620011815 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 441620011816 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 441620011817 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 441620011818 pentamer interface [polypeptide binding]; other site 441620011819 dodecaamer interface [polypeptide binding]; other site 441620011820 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 441620011821 DNA-binding site [nucleotide binding]; DNA binding site 441620011822 RNA-binding motif; other site 441620011823 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 441620011824 active site 441620011825 catalytic residues [active] 441620011826 metal binding site [ion binding]; metal-binding site 441620011827 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 441620011828 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 441620011829 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 441620011830 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 441620011831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441620011832 Coenzyme A binding pocket [chemical binding]; other site 441620011833 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 441620011834 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 441620011835 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 441620011836 fructuronate transporter; Provisional; Region: PRK10034; cl15264 441620011837 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 441620011838 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 441620011839 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 441620011840 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 441620011841 NAD(P) binding site [chemical binding]; other site 441620011842 active site 441620011843 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 441620011844 Aspartase; Region: Aspartase; cd01357 441620011845 active sites [active] 441620011846 tetramer interface [polypeptide binding]; other site 441620011847 Porin subfamily; Region: Porin_2; pfam02530 441620011848 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 441620011849 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441620011850 substrate binding pocket [chemical binding]; other site 441620011851 membrane-bound complex binding site; other site 441620011852 hinge residues; other site 441620011853 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 441620011854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620011855 dimer interface [polypeptide binding]; other site 441620011856 conserved gate region; other site 441620011857 putative PBP binding loops; other site 441620011858 ABC-ATPase subunit interface; other site 441620011859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620011860 dimer interface [polypeptide binding]; other site 441620011861 conserved gate region; other site 441620011862 putative PBP binding loops; other site 441620011863 ABC-ATPase subunit interface; other site 441620011864 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 441620011865 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 441620011866 Walker A/P-loop; other site 441620011867 ATP binding site [chemical binding]; other site 441620011868 Q-loop/lid; other site 441620011869 ABC transporter signature motif; other site 441620011870 Walker B; other site 441620011871 D-loop; other site 441620011872 H-loop/switch region; other site 441620011873 Protein of unknown function, DUF606; Region: DUF606; pfam04657 441620011874 Protein of unknown function, DUF606; Region: DUF606; pfam04657 441620011875 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 441620011876 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 441620011877 transmembrane helices; other site 441620011878 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 441620011879 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 441620011880 active site 441620011881 metal binding site [ion binding]; metal-binding site 441620011882 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 441620011883 nudix motif; other site 441620011884 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 441620011885 SPFH domain / Band 7 family; Region: Band_7; pfam01145 441620011886 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 441620011887 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 441620011888 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 441620011889 acyl-activating enzyme (AAE) consensus motif; other site 441620011890 AMP binding site [chemical binding]; other site 441620011891 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 441620011892 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 441620011893 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 441620011894 putative trimer interface [polypeptide binding]; other site 441620011895 putative CoA binding site [chemical binding]; other site 441620011896 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 441620011897 Helix-turn-helix domain; Region: HTH_37; pfam13744 441620011898 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 441620011899 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 441620011900 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 441620011901 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441620011902 catalytic residue [active] 441620011903 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 441620011904 putative ABC transporter; Region: ycf24; CHL00085 441620011905 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 441620011906 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 441620011907 Walker A/P-loop; other site 441620011908 ATP binding site [chemical binding]; other site 441620011909 Q-loop/lid; other site 441620011910 ABC transporter signature motif; other site 441620011911 Walker B; other site 441620011912 D-loop; other site 441620011913 H-loop/switch region; other site 441620011914 FeS assembly protein SufD; Region: sufD; TIGR01981 441620011915 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 441620011916 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 441620011917 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 441620011918 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441620011919 catalytic residue [active] 441620011920 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 441620011921 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 441620011922 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620011923 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620011924 metal binding site [ion binding]; metal-binding site 441620011925 active site 441620011926 I-site; other site 441620011927 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 441620011928 DEAD-like helicases superfamily; Region: DEXDc; smart00487 441620011929 ATP binding site [chemical binding]; other site 441620011930 Mg++ binding site [ion binding]; other site 441620011931 motif III; other site 441620011932 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441620011933 nucleotide binding region [chemical binding]; other site 441620011934 ATP-binding site [chemical binding]; other site 441620011935 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 441620011936 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 441620011937 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 441620011938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441620011939 motif II; other site 441620011940 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 441620011941 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441620011942 Walker A/P-loop; other site 441620011943 ATP binding site [chemical binding]; other site 441620011944 Q-loop/lid; other site 441620011945 ABC transporter signature motif; other site 441620011946 Walker B; other site 441620011947 D-loop; other site 441620011948 H-loop/switch region; other site 441620011949 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 441620011950 active site 441620011951 catalytic triad [active] 441620011952 oxyanion hole [active] 441620011953 switch loop; other site 441620011954 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 441620011955 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 441620011956 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 441620011957 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 441620011958 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 441620011959 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 441620011960 putative homodimer interface [polypeptide binding]; other site 441620011961 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 441620011962 heterodimer interface [polypeptide binding]; other site 441620011963 homodimer interface [polypeptide binding]; other site 441620011964 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 441620011965 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 441620011966 23S rRNA interface [nucleotide binding]; other site 441620011967 L7/L12 interface [polypeptide binding]; other site 441620011968 putative thiostrepton binding site; other site 441620011969 L25 interface [polypeptide binding]; other site 441620011970 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 441620011971 mRNA/rRNA interface [nucleotide binding]; other site 441620011972 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 441620011973 Cytochrome P450; Region: p450; cl12078 441620011974 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 441620011975 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441620011976 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441620011977 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 441620011978 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 441620011979 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 441620011980 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 441620011981 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 441620011982 Probable Catalytic site; other site 441620011983 metal-binding site 441620011984 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 441620011985 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 441620011986 dimer interface [polypeptide binding]; other site 441620011987 anticodon binding site; other site 441620011988 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 441620011989 motif 1; other site 441620011990 dimer interface [polypeptide binding]; other site 441620011991 active site 441620011992 motif 2; other site 441620011993 GAD domain; Region: GAD; pfam02938 441620011994 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 441620011995 active site 441620011996 motif 3; other site 441620011997 biotin synthase; Region: bioB; TIGR00433 441620011998 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441620011999 FeS/SAM binding site; other site 441620012000 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 441620012001 Predicted integral membrane protein [Function unknown]; Region: COG5616 441620012002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441620012003 binding surface 441620012004 TPR motif; other site 441620012005 Serine hydrolase; Region: Ser_hydrolase; cl17834 441620012006 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 441620012007 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 441620012008 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 441620012009 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 441620012010 arogenate dehydrogenase; Region: PLN02256 441620012011 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 441620012012 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 441620012013 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 441620012014 PAS domain S-box; Region: sensory_box; TIGR00229 441620012015 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620012016 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620012017 metal binding site [ion binding]; metal-binding site 441620012018 active site 441620012019 I-site; other site 441620012020 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 441620012021 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 441620012022 B12 binding site [chemical binding]; other site 441620012023 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 441620012024 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 441620012025 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 441620012026 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 441620012027 23S rRNA interface [nucleotide binding]; other site 441620012028 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 441620012029 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 441620012030 L11 interface [polypeptide binding]; other site 441620012031 putative EF-Tu interaction site [polypeptide binding]; other site 441620012032 putative EF-G interaction site [polypeptide binding]; other site 441620012033 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 441620012034 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 441620012035 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 441620012036 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 441620012037 RPB11 interaction site [polypeptide binding]; other site 441620012038 RPB12 interaction site [polypeptide binding]; other site 441620012039 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 441620012040 RPB3 interaction site [polypeptide binding]; other site 441620012041 RPB1 interaction site [polypeptide binding]; other site 441620012042 RPB11 interaction site [polypeptide binding]; other site 441620012043 RPB10 interaction site [polypeptide binding]; other site 441620012044 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 441620012045 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 441620012046 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 441620012047 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 441620012048 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 441620012049 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 441620012050 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 441620012051 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 441620012052 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 441620012053 DNA binding site [nucleotide binding] 441620012054 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 441620012055 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 441620012056 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 441620012057 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 441620012058 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 441620012059 homotrimer interaction site [polypeptide binding]; other site 441620012060 putative active site [active] 441620012061 Predicted membrane protein [Function unknown]; Region: COG2261 441620012062 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 441620012063 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 441620012064 putative C-terminal domain interface [polypeptide binding]; other site 441620012065 putative GSH binding site (G-site) [chemical binding]; other site 441620012066 putative dimer interface [polypeptide binding]; other site 441620012067 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 441620012068 dimer interface [polypeptide binding]; other site 441620012069 N-terminal domain interface [polypeptide binding]; other site 441620012070 putative substrate binding pocket (H-site) [chemical binding]; other site 441620012071 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 441620012072 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 441620012073 RNase E interface [polypeptide binding]; other site 441620012074 trimer interface [polypeptide binding]; other site 441620012075 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 441620012076 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 441620012077 RNase E interface [polypeptide binding]; other site 441620012078 trimer interface [polypeptide binding]; other site 441620012079 active site 441620012080 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 441620012081 putative nucleic acid binding region [nucleotide binding]; other site 441620012082 G-X-X-G motif; other site 441620012083 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 441620012084 RNA binding site [nucleotide binding]; other site 441620012085 domain interface; other site 441620012086 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 441620012087 16S/18S rRNA binding site [nucleotide binding]; other site 441620012088 S13e-L30e interaction site [polypeptide binding]; other site 441620012089 25S rRNA binding site [nucleotide binding]; other site 441620012090 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 441620012091 putative active site [active] 441620012092 putative metal binding site [ion binding]; other site 441620012093 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 441620012094 amino acid transporter; Region: 2A0306; TIGR00909 441620012095 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 441620012096 putative catalytic site [active] 441620012097 putative phosphate binding site [ion binding]; other site 441620012098 active site 441620012099 metal binding site A [ion binding]; metal-binding site 441620012100 DNA binding site [nucleotide binding] 441620012101 putative AP binding site [nucleotide binding]; other site 441620012102 putative metal binding site B [ion binding]; other site 441620012103 Sensors of blue-light using FAD; Region: BLUF; pfam04940 441620012104 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620012105 metal binding site [ion binding]; metal-binding site 441620012106 active site 441620012107 I-site; other site 441620012108 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 441620012109 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 441620012110 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 441620012111 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 441620012112 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 441620012113 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 441620012114 NAD synthetase; Reviewed; Region: nadE; PRK02628 441620012115 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 441620012116 multimer interface [polypeptide binding]; other site 441620012117 active site 441620012118 catalytic triad [active] 441620012119 protein interface 1 [polypeptide binding]; other site 441620012120 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 441620012121 homodimer interface [polypeptide binding]; other site 441620012122 NAD binding pocket [chemical binding]; other site 441620012123 ATP binding pocket [chemical binding]; other site 441620012124 Mg binding site [ion binding]; other site 441620012125 active-site loop [active] 441620012126 response regulator; Provisional; Region: PRK13435 441620012127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620012128 active site 441620012129 phosphorylation site [posttranslational modification] 441620012130 intermolecular recognition site; other site 441620012131 dimerization interface [polypeptide binding]; other site 441620012132 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620012133 PAS domain; Region: PAS_9; pfam13426 441620012134 putative active site [active] 441620012135 heme pocket [chemical binding]; other site 441620012136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620012137 Histidine kinase; Region: HisKA_2; pfam07568 441620012138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620012139 ATP binding site [chemical binding]; other site 441620012140 Mg2+ binding site [ion binding]; other site 441620012141 G-X-G motif; other site 441620012142 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 441620012143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620012144 EcsC protein family; Region: EcsC; pfam12787 441620012145 NnrU protein; Region: NnrU; pfam07298 441620012146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 441620012147 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 441620012148 GTP-binding protein Der; Reviewed; Region: PRK00093 441620012149 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 441620012150 G1 box; other site 441620012151 GTP/Mg2+ binding site [chemical binding]; other site 441620012152 Switch I region; other site 441620012153 G2 box; other site 441620012154 Switch II region; other site 441620012155 G3 box; other site 441620012156 G4 box; other site 441620012157 G5 box; other site 441620012158 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 441620012159 G1 box; other site 441620012160 GTP/Mg2+ binding site [chemical binding]; other site 441620012161 Switch I region; other site 441620012162 G2 box; other site 441620012163 G3 box; other site 441620012164 Switch II region; other site 441620012165 G4 box; other site 441620012166 G5 box; other site 441620012167 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441620012168 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 441620012169 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 441620012170 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 441620012171 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 441620012172 DNA binding site [nucleotide binding] 441620012173 catalytic residue [active] 441620012174 H2TH interface [polypeptide binding]; other site 441620012175 putative catalytic residues [active] 441620012176 turnover-facilitating residue; other site 441620012177 intercalation triad [nucleotide binding]; other site 441620012178 8OG recognition residue [nucleotide binding]; other site 441620012179 putative reading head residues; other site 441620012180 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 441620012181 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 441620012182 Predicted transcriptional regulator [Transcription]; Region: COG1959 441620012183 Transcriptional regulator; Region: Rrf2; pfam02082 441620012184 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 441620012185 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 441620012186 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441620012187 CheB methylesterase; Region: CheB_methylest; pfam01339 441620012188 PAS domain S-box; Region: sensory_box; TIGR00229 441620012189 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 441620012190 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620012191 putative active site [active] 441620012192 heme pocket [chemical binding]; other site 441620012193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620012194 dimer interface [polypeptide binding]; other site 441620012195 phosphorylation site [posttranslational modification] 441620012196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620012197 ATP binding site [chemical binding]; other site 441620012198 Mg2+ binding site [ion binding]; other site 441620012199 G-X-G motif; other site 441620012200 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620012201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620012202 active site 441620012203 phosphorylation site [posttranslational modification] 441620012204 intermolecular recognition site; other site 441620012205 dimerization interface [polypeptide binding]; other site 441620012206 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 441620012207 GSH binding site (G-site) [chemical binding]; other site 441620012208 C-terminal domain interface [polypeptide binding]; other site 441620012209 dimer interface [polypeptide binding]; other site 441620012210 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 441620012211 dimer interface [polypeptide binding]; other site 441620012212 N-terminal domain interface [polypeptide binding]; other site 441620012213 substrate binding pocket (H-site) [chemical binding]; other site 441620012214 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 441620012215 excinuclease ABC subunit B; Provisional; Region: PRK05298 441620012216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441620012217 ATP binding site [chemical binding]; other site 441620012218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441620012219 nucleotide binding region [chemical binding]; other site 441620012220 ATP-binding site [chemical binding]; other site 441620012221 Ultra-violet resistance protein B; Region: UvrB; pfam12344 441620012222 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 441620012223 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 441620012224 putative active site [active] 441620012225 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620012226 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620012227 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 441620012228 putative effector binding pocket; other site 441620012229 dimerization interface [polypeptide binding]; other site 441620012230 DoxX; Region: DoxX; cl17842 441620012231 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 441620012232 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 441620012233 putative metal binding site [ion binding]; other site 441620012234 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 441620012235 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14839 441620012236 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 441620012237 catalytic residue [active] 441620012238 putative FPP diphosphate binding site; other site 441620012239 putative FPP binding hydrophobic cleft; other site 441620012240 dimer interface [polypeptide binding]; other site 441620012241 putative IPP diphosphate binding site; other site 441620012242 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 441620012243 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 441620012244 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 441620012245 glycerol kinase; Provisional; Region: glpK; PRK00047 441620012246 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 441620012247 N- and C-terminal domain interface [polypeptide binding]; other site 441620012248 active site 441620012249 MgATP binding site [chemical binding]; other site 441620012250 catalytic site [active] 441620012251 metal binding site [ion binding]; metal-binding site 441620012252 putative homotetramer interface [polypeptide binding]; other site 441620012253 glycerol binding site [chemical binding]; other site 441620012254 homodimer interface [polypeptide binding]; other site 441620012255 hypothetical protein; Provisional; Region: PRK06489 441620012256 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 441620012257 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 441620012258 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441620012259 dimerization interface [polypeptide binding]; other site 441620012260 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620012261 dimer interface [polypeptide binding]; other site 441620012262 putative CheW interface [polypeptide binding]; other site 441620012263 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 441620012264 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 441620012265 active site 441620012266 catalytic site [active] 441620012267 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 441620012268 homotrimer interaction site [polypeptide binding]; other site 441620012269 putative active site [active] 441620012270 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 441620012271 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 441620012272 putative active site [active] 441620012273 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441620012274 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 441620012275 Walker A/P-loop; other site 441620012276 ATP binding site [chemical binding]; other site 441620012277 Q-loop/lid; other site 441620012278 ABC transporter signature motif; other site 441620012279 Walker B; other site 441620012280 D-loop; other site 441620012281 H-loop/switch region; other site 441620012282 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 441620012283 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620012284 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620012285 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 441620012286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441620012287 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441620012288 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 441620012289 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 441620012290 inhibitor-cofactor binding pocket; inhibition site 441620012291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620012292 catalytic residue [active] 441620012293 ornithine carbamoyltransferase; Provisional; Region: PRK00779 441620012294 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 441620012295 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 441620012296 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 441620012297 putative hydrophobic ligand binding site [chemical binding]; other site 441620012298 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 441620012299 putative dimer interface [polypeptide binding]; other site 441620012300 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 441620012301 short chain dehydrogenase; Provisional; Region: PRK06523 441620012302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620012303 NAD(P) binding site [chemical binding]; other site 441620012304 active site 441620012305 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 441620012306 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441620012307 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 441620012308 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620012309 PAS domain; Region: PAS_9; pfam13426 441620012310 putative active site [active] 441620012311 heme pocket [chemical binding]; other site 441620012312 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 441620012313 GAF domain; Region: GAF; pfam01590 441620012314 Phytochrome region; Region: PHY; pfam00360 441620012315 Histidine kinase; Region: HisKA_2; pfam07568 441620012316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620012317 ATP binding site [chemical binding]; other site 441620012318 Mg2+ binding site [ion binding]; other site 441620012319 G-X-G motif; other site 441620012320 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 441620012321 heme binding pocket [chemical binding]; other site 441620012322 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 441620012323 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 441620012324 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 441620012325 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 441620012326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620012327 Walker A motif; other site 441620012328 ATP binding site [chemical binding]; other site 441620012329 Walker B motif; other site 441620012330 arginine finger; other site 441620012331 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441620012332 flagellar motor switch protein; Reviewed; Region: PRK08916 441620012333 flagellar assembly protein H; Validated; Region: fliH; PRK06032 441620012334 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 441620012335 FliG C-terminal domain; Region: FliG_C; pfam01706 441620012336 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 441620012337 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 441620012338 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 441620012339 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 441620012340 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 441620012341 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 441620012342 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 441620012343 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 441620012344 Ligand Binding Site [chemical binding]; other site 441620012345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620012346 S-adenosylmethionine binding site [chemical binding]; other site 441620012347 Uncharacterized conserved protein [Function unknown]; Region: COG0398 441620012348 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 441620012349 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620012350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620012351 ATP binding site [chemical binding]; other site 441620012352 Mg2+ binding site [ion binding]; other site 441620012353 G-X-G motif; other site 441620012354 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 441620012355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620012356 salt bridge; other site 441620012357 non-specific DNA binding site [nucleotide binding]; other site 441620012358 sequence-specific DNA binding site [nucleotide binding]; other site 441620012359 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 441620012360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620012361 putative substrate translocation pore; other site 441620012362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620012363 putative substrate translocation pore; other site 441620012364 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 441620012365 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620012366 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620012367 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441620012368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441620012369 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 441620012370 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 441620012371 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 441620012372 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 441620012373 active site 441620012374 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 441620012375 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 441620012376 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 441620012377 PAS domain; Region: PAS; smart00091 441620012378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620012379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620012380 dimer interface [polypeptide binding]; other site 441620012381 phosphorylation site [posttranslational modification] 441620012382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620012383 ATP binding site [chemical binding]; other site 441620012384 Mg2+ binding site [ion binding]; other site 441620012385 G-X-G motif; other site 441620012386 Response regulator receiver domain; Region: Response_reg; pfam00072 441620012387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620012388 active site 441620012389 phosphorylation site [posttranslational modification] 441620012390 intermolecular recognition site; other site 441620012391 dimerization interface [polypeptide binding]; other site 441620012392 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 441620012393 tetramer interface [polypeptide binding]; other site 441620012394 dimer interface [polypeptide binding]; other site 441620012395 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 441620012396 tetramer interface [polypeptide binding]; other site 441620012397 dimer interface [polypeptide binding]; other site 441620012398 circadian clock protein KaiC; Reviewed; Region: PRK09302 441620012399 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441620012400 Walker A motif; other site 441620012401 ATP binding site [chemical binding]; other site 441620012402 Walker B motif; other site 441620012403 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441620012404 Walker A motif; other site 441620012405 ATP binding site [chemical binding]; other site 441620012406 Walker B motif; other site 441620012407 Response regulator receiver domain; Region: Response_reg; pfam00072 441620012408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620012409 active site 441620012410 phosphorylation site [posttranslational modification] 441620012411 intermolecular recognition site; other site 441620012412 dimerization interface [polypeptide binding]; other site 441620012413 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620012414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620012415 ATP binding site [chemical binding]; other site 441620012416 Mg2+ binding site [ion binding]; other site 441620012417 G-X-G motif; other site 441620012418 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441620012419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620012420 active site 441620012421 phosphorylation site [posttranslational modification] 441620012422 intermolecular recognition site; other site 441620012423 dimerization interface [polypeptide binding]; other site 441620012424 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620012425 DNA binding site [nucleotide binding] 441620012426 Predicted membrane protein [Function unknown]; Region: COG3212 441620012427 Staphylococcal nuclease homologues; Region: SNc; smart00318 441620012428 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 441620012429 Catalytic site; other site 441620012430 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 441620012431 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 441620012432 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 441620012433 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 441620012434 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 441620012435 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620012436 N-terminal plug; other site 441620012437 ligand-binding site [chemical binding]; other site 441620012438 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 441620012439 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 441620012440 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 441620012441 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 441620012442 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 441620012443 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 441620012444 active site 441620012445 substrate binding site [chemical binding]; other site 441620012446 metal binding site [ion binding]; metal-binding site 441620012447 Right handed beta helix region; Region: Beta_helix; pfam13229 441620012448 Right handed beta helix region; Region: Beta_helix; pfam13229 441620012449 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 441620012450 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 441620012451 Bacterial sugar transferase; Region: Bac_transf; pfam02397 441620012452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620012453 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441620012454 NAD(P) binding site [chemical binding]; other site 441620012455 active site 441620012456 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 441620012457 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 441620012458 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441620012459 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 441620012460 NAD binding site [chemical binding]; other site 441620012461 putative substrate binding site 2 [chemical binding]; other site 441620012462 putative substrate binding site 1 [chemical binding]; other site 441620012463 active site 441620012464 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 441620012465 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 441620012466 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 441620012467 Substrate binding site; other site 441620012468 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 441620012469 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441620012470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620012471 active site 441620012472 phosphorylation site [posttranslational modification] 441620012473 intermolecular recognition site; other site 441620012474 dimerization interface [polypeptide binding]; other site 441620012475 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441620012476 DNA binding residues [nucleotide binding] 441620012477 dimerization interface [polypeptide binding]; other site 441620012478 Uncharacterized conserved protein [Function unknown]; Region: COG3391 441620012479 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 441620012480 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 441620012481 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 441620012482 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 441620012483 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 441620012484 putative hydrophobic ligand binding site [chemical binding]; other site 441620012485 protein interface [polypeptide binding]; other site 441620012486 gate; other site 441620012487 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 441620012488 metal ion-dependent adhesion site (MIDAS); other site 441620012489 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 441620012490 metal ion-dependent adhesion site (MIDAS); other site 441620012491 Protein of unknown function DUF58; Region: DUF58; pfam01882 441620012492 MoxR-like ATPases [General function prediction only]; Region: COG0714 441620012493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620012494 Walker A motif; other site 441620012495 ATP binding site [chemical binding]; other site 441620012496 Walker B motif; other site 441620012497 arginine finger; other site 441620012498 Methanol dehydrogenase beta subunit; Region: MDH; pfam02315 441620012499 cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872 441620012500 methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870 441620012501 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441620012502 substrate binding pocket [chemical binding]; other site 441620012503 membrane-bound complex binding site; other site 441620012504 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 441620012505 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 441620012506 Trp docking motif [polypeptide binding]; other site 441620012507 dimer interface [polypeptide binding]; other site 441620012508 active site 441620012509 small subunit binding site [polypeptide binding]; other site 441620012510 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 441620012511 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 441620012512 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441620012513 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 441620012514 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 441620012515 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 441620012516 Substrate binding site; other site 441620012517 Mg++ binding site; other site 441620012518 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 441620012519 putative trimer interface [polypeptide binding]; other site 441620012520 putative CoA binding site [chemical binding]; other site 441620012521 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 441620012522 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 441620012523 glutaminase active site [active] 441620012524 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 441620012525 dimer interface [polypeptide binding]; other site 441620012526 active site 441620012527 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 441620012528 dimer interface [polypeptide binding]; other site 441620012529 active site 441620012530 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 441620012531 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 441620012532 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 441620012533 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 441620012534 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 441620012535 RNA polymerase sigma factor; Provisional; Region: PRK12525 441620012536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441620012537 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441620012538 DNA binding residues [nucleotide binding] 441620012539 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 441620012540 FecR protein; Region: FecR; pfam04773 441620012541 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 441620012542 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 441620012543 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441620012544 catalytic residue [active] 441620012545 Uncharacterized conserved protein [Function unknown]; Region: COG1284 441620012546 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 441620012547 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 441620012548 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 441620012549 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 441620012550 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 441620012551 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 441620012552 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 441620012553 N-terminal plug; other site 441620012554 ligand-binding site [chemical binding]; other site 441620012555 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 441620012556 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441620012557 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 441620012558 Transcriptional regulators [Transcription]; Region: GntR; COG1802 441620012559 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441620012560 DNA-binding site [nucleotide binding]; DNA binding site 441620012561 FCD domain; Region: FCD; pfam07729 441620012562 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 441620012563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620012564 putative substrate translocation pore; other site 441620012565 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 441620012566 tartrate dehydrogenase; Region: TTC; TIGR02089 441620012567 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 441620012568 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 441620012569 MOFRL family; Region: MOFRL; pfam05161 441620012570 pyruvate kinase; Provisional; Region: PRK06247 441620012571 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 441620012572 domain interfaces; other site 441620012573 active site 441620012574 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441620012575 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441620012576 Walker A/P-loop; other site 441620012577 ATP binding site [chemical binding]; other site 441620012578 Q-loop/lid; other site 441620012579 ABC transporter signature motif; other site 441620012580 Walker B; other site 441620012581 D-loop; other site 441620012582 H-loop/switch region; other site 441620012583 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 441620012584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620012585 dimer interface [polypeptide binding]; other site 441620012586 conserved gate region; other site 441620012587 putative PBP binding loops; other site 441620012588 ABC-ATPase subunit interface; other site 441620012589 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 441620012590 NMT1-like family; Region: NMT1_2; pfam13379 441620012591 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 441620012592 Rubredoxin [Energy production and conversion]; Region: COG1773 441620012593 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 441620012594 iron binding site [ion binding]; other site 441620012595 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 441620012596 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 441620012597 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 441620012598 OsmC-like protein; Region: OsmC; pfam02566 441620012599 Nif-specific regulatory protein; Region: nifA; TIGR01817 441620012600 GAF domain; Region: GAF; pfam01590 441620012601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620012602 Walker A motif; other site 441620012603 ATP binding site [chemical binding]; other site 441620012604 Walker B motif; other site 441620012605 arginine finger; other site 441620012606 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441620012607 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 441620012608 Uncharacterized conserved protein [Function unknown]; Region: COG2928 441620012609 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 441620012610 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 441620012611 generic binding surface II; other site 441620012612 ssDNA binding site; other site 441620012613 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441620012614 ATP binding site [chemical binding]; other site 441620012615 putative Mg++ binding site [ion binding]; other site 441620012616 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441620012617 nucleotide binding region [chemical binding]; other site 441620012618 ATP-binding site [chemical binding]; other site 441620012619 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441620012620 extended (e) SDRs; Region: SDR_e; cd08946 441620012621 NAD(P) binding site [chemical binding]; other site 441620012622 active site 441620012623 substrate binding site [chemical binding]; other site 441620012624 Uncharacterized conserved protein [Function unknown]; Region: COG2938 441620012625 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 441620012626 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 441620012627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441620012628 ATP binding site [chemical binding]; other site 441620012629 putative Mg++ binding site [ion binding]; other site 441620012630 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441620012631 nucleotide binding region [chemical binding]; other site 441620012632 ATP-binding site [chemical binding]; other site 441620012633 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 441620012634 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 441620012635 DNA-binding site [nucleotide binding]; DNA binding site 441620012636 RNA-binding motif; other site 441620012637 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 441620012638 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441620012639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620012640 dimer interface [polypeptide binding]; other site 441620012641 phosphorylation site [posttranslational modification] 441620012642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620012643 ATP binding site [chemical binding]; other site 441620012644 G-X-G motif; other site 441620012645 Response regulator receiver domain; Region: Response_reg; pfam00072 441620012646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620012647 active site 441620012648 phosphorylation site [posttranslational modification] 441620012649 intermolecular recognition site; other site 441620012650 dimerization interface [polypeptide binding]; other site 441620012651 acyl-CoA synthetase; Validated; Region: PRK08162 441620012652 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 441620012653 acyl-activating enzyme (AAE) consensus motif; other site 441620012654 putative active site [active] 441620012655 AMP binding site [chemical binding]; other site 441620012656 putative CoA binding site [chemical binding]; other site 441620012657 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 441620012658 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 441620012659 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 441620012660 Ligand binding site; other site 441620012661 Putative Catalytic site; other site 441620012662 DXD motif; other site 441620012663 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 441620012664 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 441620012665 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 441620012666 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 441620012667 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 441620012668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620012669 NAD(P) binding site [chemical binding]; other site 441620012670 active site 441620012671 hypothetical protein; Validated; Region: PRK00029 441620012672 Uncharacterized conserved protein [Function unknown]; Region: COG0397 441620012673 EamA-like transporter family; Region: EamA; pfam00892 441620012674 EamA-like transporter family; Region: EamA; pfam00892 441620012675 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 441620012676 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620012677 Histidine kinase; Region: HisKA_2; pfam07568 441620012678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620012679 ATP binding site [chemical binding]; other site 441620012680 Mg2+ binding site [ion binding]; other site 441620012681 G-X-G motif; other site 441620012682 Winged helix-turn helix; Region: HTH_29; pfam13551 441620012683 Helix-turn-helix domain; Region: HTH_28; pfam13518 441620012684 Homeodomain-like domain; Region: HTH_32; pfam13565 441620012685 Integrase core domain; Region: rve; pfam00665 441620012686 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 441620012687 active site 441620012688 oxyanion hole [active] 441620012689 catalytic triad [active] 441620012690 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 441620012691 heme-binding site [chemical binding]; other site 441620012692 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620012693 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620012694 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 441620012695 putative effector binding pocket; other site 441620012696 putative dimerization interface [polypeptide binding]; other site 441620012697 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 441620012698 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 441620012699 active site 441620012700 catalytic tetrad [active] 441620012701 putative hydrolase; Provisional; Region: PRK02113 441620012702 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 441620012703 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 441620012704 active site 441620012705 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 441620012706 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 441620012707 active site 441620012708 HIGH motif; other site 441620012709 KMSKS motif; other site 441620012710 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 441620012711 tRNA binding surface [nucleotide binding]; other site 441620012712 anticodon binding site; other site 441620012713 DNA polymerase III subunit delta'; Validated; Region: PRK07471 441620012714 DNA polymerase III subunit delta'; Validated; Region: PRK08485 441620012715 thymidylate kinase; Validated; Region: tmk; PRK00698 441620012716 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 441620012717 TMP-binding site; other site 441620012718 ATP-binding site [chemical binding]; other site 441620012719 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 441620012720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620012721 ABC-ATPase subunit interface; other site 441620012722 putative PBP binding loops; other site 441620012723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 441620012724 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 441620012725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620012726 Walker A/P-loop; other site 441620012727 ATP binding site [chemical binding]; other site 441620012728 Q-loop/lid; other site 441620012729 ABC transporter signature motif; other site 441620012730 Walker B; other site 441620012731 D-loop; other site 441620012732 H-loop/switch region; other site 441620012733 TOBE domain; Region: TOBE_2; pfam08402 441620012734 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441620012735 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 441620012736 ligand binding site [chemical binding]; other site 441620012737 flexible hinge region; other site 441620012738 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 441620012739 Predicted membrane protein [Function unknown]; Region: COG5373 441620012740 Predicted membrane protein [Function unknown]; Region: COG5373 441620012741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620012742 D-galactonate transporter; Region: 2A0114; TIGR00893 441620012743 putative substrate translocation pore; other site 441620012744 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 441620012745 homodimer interface [polypeptide binding]; other site 441620012746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620012747 catalytic residue [active] 441620012748 Transcriptional regulators [Transcription]; Region: FadR; COG2186 441620012749 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441620012750 DNA-binding site [nucleotide binding]; DNA binding site 441620012751 FCD domain; Region: FCD; pfam07729 441620012752 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 441620012753 short chain dehydrogenase; Provisional; Region: PRK06701 441620012754 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 441620012755 NAD binding site [chemical binding]; other site 441620012756 metal binding site [ion binding]; metal-binding site 441620012757 active site 441620012758 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 441620012759 FAD binding domain; Region: FAD_binding_4; pfam01565 441620012760 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 441620012761 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 441620012762 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 441620012763 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 441620012764 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 441620012765 tetramerization interface [polypeptide binding]; other site 441620012766 NAD(P) binding site [chemical binding]; other site 441620012767 catalytic residues [active] 441620012768 Hint domain; Region: Hint_2; pfam13403 441620012769 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 441620012770 lipoate-protein ligase B; Provisional; Region: PRK14341 441620012771 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441620012772 active site 441620012773 Domain of unknown function (DUF892); Region: DUF892; pfam05974 441620012774 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 441620012775 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 441620012776 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 441620012777 Protein of unknown function, DUF606; Region: DUF606; pfam04657 441620012778 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 441620012779 Domain of unknown function DUF20; Region: UPF0118; pfam01594 441620012780 Response regulator receiver domain; Region: Response_reg; pfam00072 441620012781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620012782 active site 441620012783 phosphorylation site [posttranslational modification] 441620012784 intermolecular recognition site; other site 441620012785 dimerization interface [polypeptide binding]; other site 441620012786 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 441620012787 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 441620012788 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 441620012789 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 441620012790 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 441620012791 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 441620012792 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 441620012793 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620012794 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 441620012795 putative active site [active] 441620012796 heme pocket [chemical binding]; other site 441620012797 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620012798 putative active site [active] 441620012799 heme pocket [chemical binding]; other site 441620012800 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620012801 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620012802 dimer interface [polypeptide binding]; other site 441620012803 phosphorylation site [posttranslational modification] 441620012804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620012805 ATP binding site [chemical binding]; other site 441620012806 Mg2+ binding site [ion binding]; other site 441620012807 G-X-G motif; other site 441620012808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620012809 active site 441620012810 phosphorylation site [posttranslational modification] 441620012811 intermolecular recognition site; other site 441620012812 dimerization interface [polypeptide binding]; other site 441620012813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620012814 active site 441620012815 phosphorylation site [posttranslational modification] 441620012816 intermolecular recognition site; other site 441620012817 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 441620012818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441620012819 DNA-binding site [nucleotide binding]; DNA binding site 441620012820 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441620012821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620012822 homodimer interface [polypeptide binding]; other site 441620012823 catalytic residue [active] 441620012824 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 441620012825 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441620012826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620012827 active site 441620012828 phosphorylation site [posttranslational modification] 441620012829 intermolecular recognition site; other site 441620012830 dimerization interface [polypeptide binding]; other site 441620012831 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441620012832 DNA binding residues [nucleotide binding] 441620012833 dimerization interface [polypeptide binding]; other site 441620012834 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 441620012835 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441620012836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 441620012837 L-lactate permease; Region: Lactate_perm; cl00701 441620012838 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 441620012839 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 441620012840 dimanganese center [ion binding]; other site 441620012841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620012842 non-specific DNA binding site [nucleotide binding]; other site 441620012843 salt bridge; other site 441620012844 sequence-specific DNA binding site [nucleotide binding]; other site 441620012845 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 441620012846 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 441620012847 substrate binding pocket [chemical binding]; other site 441620012848 substrate-Mg2+ binding site; other site 441620012849 aspartate-rich region 2; other site 441620012850 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 441620012851 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 441620012852 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 441620012853 Protein export membrane protein; Region: SecD_SecF; pfam02355 441620012854 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 441620012855 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 441620012856 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 441620012857 Preprotein translocase subunit; Region: YajC; pfam02699 441620012858 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 441620012859 Protein of unknown function (DUF815); Region: DUF815; pfam05673 441620012860 Walker A motif; other site 441620012861 ATP binding site [chemical binding]; other site 441620012862 Walker B motif; other site 441620012863 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 441620012864 Peptidase family M23; Region: Peptidase_M23; pfam01551 441620012865 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 441620012866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620012867 S-adenosylmethionine binding site [chemical binding]; other site 441620012868 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 441620012869 seryl-tRNA synthetase; Provisional; Region: PRK05431 441620012870 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 441620012871 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 441620012872 dimer interface [polypeptide binding]; other site 441620012873 active site 441620012874 motif 1; other site 441620012875 motif 2; other site 441620012876 motif 3; other site 441620012877 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441620012878 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 441620012879 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 441620012880 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 441620012881 substrate binding site [chemical binding]; other site 441620012882 oxyanion hole (OAH) forming residues; other site 441620012883 trimer interface [polypeptide binding]; other site 441620012884 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 441620012885 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 441620012886 dimer interface [polypeptide binding]; other site 441620012887 allosteric magnesium binding site [ion binding]; other site 441620012888 active site 441620012889 aspartate-rich active site metal binding site; other site 441620012890 Schiff base residues; other site 441620012891 RDD family; Region: RDD; pfam06271 441620012892 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 441620012893 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 441620012894 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 441620012895 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 441620012896 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 441620012897 maltose O-acetyltransferase; Provisional; Region: PRK10092 441620012898 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 441620012899 active site 441620012900 substrate binding site [chemical binding]; other site 441620012901 trimer interface [polypeptide binding]; other site 441620012902 CoA binding site [chemical binding]; other site 441620012903 Predicted metalloprotease [General function prediction only]; Region: COG2321 441620012904 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 441620012905 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 441620012906 Fe-S cluster binding site [ion binding]; other site 441620012907 active site 441620012908 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 441620012909 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 441620012910 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 441620012911 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 441620012912 putative active site pocket [active] 441620012913 cleavage site 441620012914 Predicted permeases [General function prediction only]; Region: RarD; COG2962 441620012915 Ribosome modulation factor; Region: RMF; cl01207 441620012916 cystathionine beta-lyase; Provisional; Region: PRK05967 441620012917 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 441620012918 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441620012919 catalytic residue [active] 441620012920 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 441620012921 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620012922 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 441620012923 dimerization interface [polypeptide binding]; other site 441620012924 substrate binding pocket [chemical binding]; other site 441620012925 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 441620012926 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 441620012927 PAS fold; Region: PAS_4; pfam08448 441620012928 PAS fold; Region: PAS_4; pfam08448 441620012929 PAS domain S-box; Region: sensory_box; TIGR00229 441620012930 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620012931 putative active site [active] 441620012932 heme pocket [chemical binding]; other site 441620012933 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 441620012934 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620012935 putative active site [active] 441620012936 heme pocket [chemical binding]; other site 441620012937 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 441620012938 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620012939 putative active site [active] 441620012940 heme pocket [chemical binding]; other site 441620012941 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620012942 dimer interface [polypeptide binding]; other site 441620012943 phosphorylation site [posttranslational modification] 441620012944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620012945 ATP binding site [chemical binding]; other site 441620012946 Mg2+ binding site [ion binding]; other site 441620012947 G-X-G motif; other site 441620012948 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620012949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620012950 active site 441620012951 phosphorylation site [posttranslational modification] 441620012952 intermolecular recognition site; other site 441620012953 dimerization interface [polypeptide binding]; other site 441620012954 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 441620012955 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 441620012956 Probable Catalytic site; other site 441620012957 metal-binding site 441620012958 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 441620012959 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 441620012960 Probable Catalytic site; other site 441620012961 metal-binding site 441620012962 Cupin domain; Region: Cupin_2; cl17218 441620012963 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 441620012964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441620012965 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 441620012966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620012967 ATP binding site [chemical binding]; other site 441620012968 Mg2+ binding site [ion binding]; other site 441620012969 G-X-G motif; other site 441620012970 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 441620012971 ATP binding site [chemical binding]; other site 441620012972 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 441620012973 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 441620012974 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 441620012975 active site 441620012976 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 441620012977 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441620012978 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441620012979 ABC transporter; Region: ABC_tran_2; pfam12848 441620012980 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441620012981 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 441620012982 RibD C-terminal domain; Region: RibD_C; cl17279 441620012983 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 441620012984 OsmC-like protein; Region: OsmC; cl00767 441620012985 Domain of unknown function (DUF336); Region: DUF336; cl01249 441620012986 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 441620012987 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 441620012988 peptide binding site [polypeptide binding]; other site 441620012989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620012990 dimer interface [polypeptide binding]; other site 441620012991 conserved gate region; other site 441620012992 putative PBP binding loops; other site 441620012993 ABC-ATPase subunit interface; other site 441620012994 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 441620012995 benzoate transport; Region: 2A0115; TIGR00895 441620012996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620012997 putative substrate translocation pore; other site 441620012998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620012999 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 441620013000 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 441620013001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 441620013002 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620013003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620013004 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 441620013005 dimerization interface [polypeptide binding]; other site 441620013006 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 441620013007 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 441620013008 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 441620013009 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 441620013010 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 441620013011 DsbD alpha interface [polypeptide binding]; other site 441620013012 catalytic residues [active] 441620013013 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 441620013014 MutS domain I; Region: MutS_I; pfam01624 441620013015 MutS domain II; Region: MutS_II; pfam05188 441620013016 MutS domain III; Region: MutS_III; pfam05192 441620013017 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 441620013018 Walker A/P-loop; other site 441620013019 ATP binding site [chemical binding]; other site 441620013020 Q-loop/lid; other site 441620013021 ABC transporter signature motif; other site 441620013022 Walker B; other site 441620013023 D-loop; other site 441620013024 H-loop/switch region; other site 441620013025 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 441620013026 ATP binding site [chemical binding]; other site 441620013027 putative Mg++ binding site [ion binding]; other site 441620013028 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441620013029 nucleotide binding region [chemical binding]; other site 441620013030 ATP-binding site [chemical binding]; other site 441620013031 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 441620013032 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 441620013033 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 441620013034 active site 441620013035 dimer interface [polypeptide binding]; other site 441620013036 metal binding site [ion binding]; metal-binding site 441620013037 glutathione binding site [chemical binding]; other site 441620013038 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 441620013039 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441620013040 active site 441620013041 DNA binding site [nucleotide binding] 441620013042 Int/Topo IB signature motif; other site 441620013043 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 441620013044 catalytic core [active] 441620013045 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 441620013046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 441620013047 MOSC domain; Region: MOSC; pfam03473 441620013048 3-alpha domain; Region: 3-alpha; pfam03475 441620013049 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 441620013050 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 441620013051 NAD binding site [chemical binding]; other site 441620013052 homotetramer interface [polypeptide binding]; other site 441620013053 homodimer interface [polypeptide binding]; other site 441620013054 substrate binding site [chemical binding]; other site 441620013055 active site 441620013056 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 441620013057 HSP70 interaction site [polypeptide binding]; other site 441620013058 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 441620013059 substrate binding site [polypeptide binding]; other site 441620013060 dimer interface [polypeptide binding]; other site 441620013061 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 441620013062 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 441620013063 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 441620013064 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 441620013065 Response regulator receiver domain; Region: Response_reg; pfam00072 441620013066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620013067 active site 441620013068 phosphorylation site [posttranslational modification] 441620013069 intermolecular recognition site; other site 441620013070 dimerization interface [polypeptide binding]; other site 441620013071 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 441620013072 classical (c) SDRs; Region: SDR_c; cd05233 441620013073 NAD(P) binding site [chemical binding]; other site 441620013074 active site 441620013075 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 441620013076 nudix motif; other site 441620013077 Protein of unknown function (DUF2385); Region: DUF2385; pfam09539 441620013078 dihydroorotase; Validated; Region: PRK09060 441620013079 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 441620013080 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 441620013081 active site 441620013082 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 441620013083 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 441620013084 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 441620013085 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 441620013086 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 441620013087 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 441620013088 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 441620013089 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 441620013090 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 441620013091 TPP-binding site; other site 441620013092 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 441620013093 PYR/PP interface [polypeptide binding]; other site 441620013094 dimer interface [polypeptide binding]; other site 441620013095 TPP binding site [chemical binding]; other site 441620013096 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 441620013097 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 441620013098 E-class dimer interface [polypeptide binding]; other site 441620013099 P-class dimer interface [polypeptide binding]; other site 441620013100 active site 441620013101 Cu2+ binding site [ion binding]; other site 441620013102 Zn2+ binding site [ion binding]; other site 441620013103 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 441620013104 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441620013105 RNA binding surface [nucleotide binding]; other site 441620013106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620013107 S-adenosylmethionine binding site [chemical binding]; other site 441620013108 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 441620013109 Protein of unknown function (DUF563); Region: DUF563; pfam04577 441620013110 DHHW protein; Region: DHHW; pfam14286 441620013111 Uncharacterized conserved protein [Function unknown]; Region: COG2135 441620013112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 441620013113 Protein of unknown function, DUF482; Region: DUF482; pfam04339 441620013114 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 441620013115 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 441620013116 metal binding site [ion binding]; metal-binding site 441620013117 putative dimer interface [polypeptide binding]; other site 441620013118 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 441620013119 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 441620013120 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441620013121 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 441620013122 DNA binding site [nucleotide binding] 441620013123 active site 441620013124 Cation efflux family; Region: Cation_efflux; pfam01545 441620013125 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 441620013126 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 441620013127 HIT family signature motif; other site 441620013128 catalytic residue [active] 441620013129 PilZ domain; Region: PilZ; pfam07238 441620013130 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 441620013131 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 441620013132 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 441620013133 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 441620013134 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 441620013135 active site 441620013136 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 441620013137 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 441620013138 dimer interface [polypeptide binding]; other site 441620013139 active site 441620013140 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 441620013141 dimer interface [polypeptide binding]; other site 441620013142 active site 441620013143 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 441620013144 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 441620013145 putative active site [active] 441620013146 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 441620013147 putative catalytic site [active] 441620013148 putative metal binding site [ion binding]; other site 441620013149 putative phosphate binding site [ion binding]; other site 441620013150 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 441620013151 active site 441620013152 homotetramer interface [polypeptide binding]; other site 441620013153 homodimer interface [polypeptide binding]; other site 441620013154 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 441620013155 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 441620013156 putative active site [active] 441620013157 catalytic site [active] 441620013158 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 441620013159 putative active site [active] 441620013160 catalytic site [active] 441620013161 Uncharacterized conserved protein [Function unknown]; Region: COG0398 441620013162 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 441620013163 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 441620013164 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 441620013165 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 441620013166 Subunit I/III interface [polypeptide binding]; other site 441620013167 Subunit III/IV interface [polypeptide binding]; other site 441620013168 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 441620013169 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 441620013170 D-pathway; other site 441620013171 Putative ubiquinol binding site [chemical binding]; other site 441620013172 Low-spin heme (heme b) binding site [chemical binding]; other site 441620013173 Putative water exit pathway; other site 441620013174 Binuclear center (heme o3/CuB) [ion binding]; other site 441620013175 K-pathway; other site 441620013176 Putative proton exit pathway; other site 441620013177 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 441620013178 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 441620013179 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 441620013180 metabolite-proton symporter; Region: 2A0106; TIGR00883 441620013181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620013182 putative substrate translocation pore; other site 441620013183 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 441620013184 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 441620013185 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620013186 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441620013187 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620013188 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 441620013189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441620013190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441620013191 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441620013192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620013193 active site 441620013194 phosphorylation site [posttranslational modification] 441620013195 intermolecular recognition site; other site 441620013196 dimerization interface [polypeptide binding]; other site 441620013197 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441620013198 DNA binding residues [nucleotide binding] 441620013199 dimerization interface [polypeptide binding]; other site 441620013200 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 441620013201 Histidine kinase; Region: HisKA_3; pfam07730 441620013202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620013203 ATP binding site [chemical binding]; other site 441620013204 Mg2+ binding site [ion binding]; other site 441620013205 G-X-G motif; other site 441620013206 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441620013207 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441620013208 DNA binding residues [nucleotide binding] 441620013209 dimerization interface [polypeptide binding]; other site 441620013210 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441620013211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620013212 active site 441620013213 phosphorylation site [posttranslational modification] 441620013214 intermolecular recognition site; other site 441620013215 dimerization interface [polypeptide binding]; other site 441620013216 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441620013217 DNA binding residues [nucleotide binding] 441620013218 dimerization interface [polypeptide binding]; other site 441620013219 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441620013220 active site 441620013221 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441620013222 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 441620013223 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 441620013224 ApbE family; Region: ApbE; pfam02424 441620013225 FMN-binding domain; Region: FMN_bind; cl01081 441620013226 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 441620013227 4Fe-4S binding domain; Region: Fer4_5; pfam12801 441620013228 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 441620013229 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 441620013230 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 441620013231 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 441620013232 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 441620013233 ligand binding site [chemical binding]; other site 441620013234 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 441620013235 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 441620013236 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 441620013237 substrate binding pocket [chemical binding]; other site 441620013238 membrane-bound complex binding site; other site 441620013239 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 441620013240 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 441620013241 dimer interface [polypeptide binding]; other site 441620013242 Trp docking motif [polypeptide binding]; other site 441620013243 active site 441620013244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620013245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620013246 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 441620013247 putative dimerization interface [polypeptide binding]; other site 441620013248 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 441620013249 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 441620013250 putative ligand binding site [chemical binding]; other site 441620013251 NAD binding site [chemical binding]; other site 441620013252 catalytic site [active] 441620013253 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 441620013254 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 441620013255 substrate binding site [chemical binding]; other site 441620013256 ligand binding site [chemical binding]; other site 441620013257 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 441620013258 active site 441620013259 TIGR02594 family protein; Region: TIGR02594 441620013260 Hint domain; Region: Hint_2; pfam13403 441620013261 Cupin domain; Region: Cupin_2; pfam07883 441620013262 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 441620013263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441620013264 motif II; other site 441620013265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441620013266 TPR motif; other site 441620013267 binding surface 441620013268 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620013269 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 441620013270 Predicted membrane protein [Function unknown]; Region: COG3918 441620013271 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 441620013272 Cupin domain; Region: Cupin_2; cl17218 441620013273 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 441620013274 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441620013275 membrane-bound complex binding site; other site 441620013276 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 441620013277 active site 441620013278 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 441620013279 dimer interface [polypeptide binding]; other site 441620013280 non-prolyl cis peptide bond; other site 441620013281 insertion regions; other site 441620013282 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 441620013283 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 441620013284 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 441620013285 active site 441620013286 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 441620013287 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 441620013288 substrate binding pocket [chemical binding]; other site 441620013289 membrane-bound complex binding site; other site 441620013290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620013291 putative PBP binding loops; other site 441620013292 dimer interface [polypeptide binding]; other site 441620013293 ABC-ATPase subunit interface; other site 441620013294 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441620013295 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441620013296 Walker A/P-loop; other site 441620013297 ATP binding site [chemical binding]; other site 441620013298 Q-loop/lid; other site 441620013299 ABC transporter signature motif; other site 441620013300 Walker B; other site 441620013301 D-loop; other site 441620013302 H-loop/switch region; other site 441620013303 elongation factor Tu; Reviewed; Region: PRK00049 441620013304 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 441620013305 G1 box; other site 441620013306 GEF interaction site [polypeptide binding]; other site 441620013307 GTP/Mg2+ binding site [chemical binding]; other site 441620013308 Switch I region; other site 441620013309 G2 box; other site 441620013310 G3 box; other site 441620013311 Switch II region; other site 441620013312 G4 box; other site 441620013313 G5 box; other site 441620013314 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 441620013315 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 441620013316 Antibiotic Binding Site [chemical binding]; other site 441620013317 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441620013318 RNA binding surface [nucleotide binding]; other site 441620013319 DEAD-like helicases superfamily; Region: DEXDc; smart00487 441620013320 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441620013321 ATP binding site [chemical binding]; other site 441620013322 putative Mg++ binding site [ion binding]; other site 441620013323 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441620013324 nucleotide binding region [chemical binding]; other site 441620013325 ATP-binding site [chemical binding]; other site 441620013326 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 441620013327 Glucokinase; Region: Glucokinase; cl17310 441620013328 glucokinase, proteobacterial type; Region: glk; TIGR00749 441620013329 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 441620013330 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 441620013331 Domain of unknown function (DUF427); Region: DUF427; pfam04248 441620013332 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 441620013333 Beta-lactamase; Region: Beta-lactamase; pfam00144 441620013334 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 441620013335 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 441620013336 putative dimer interface [polypeptide binding]; other site 441620013337 [2Fe-2S] cluster binding site [ion binding]; other site 441620013338 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 441620013339 putative dimer interface [polypeptide binding]; other site 441620013340 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 441620013341 SLBB domain; Region: SLBB; pfam10531 441620013342 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 441620013343 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 441620013344 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441620013345 catalytic loop [active] 441620013346 iron binding site [ion binding]; other site 441620013347 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 441620013348 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 441620013349 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 441620013350 [4Fe-4S] binding site [ion binding]; other site 441620013351 molybdopterin cofactor binding site; other site 441620013352 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 441620013353 molybdopterin cofactor binding site; other site 441620013354 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 441620013355 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620013356 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620013357 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 441620013358 dimerization interface [polypeptide binding]; other site 441620013359 GTPase CgtA; Reviewed; Region: obgE; PRK12299 441620013360 GTP1/OBG; Region: GTP1_OBG; pfam01018 441620013361 Obg GTPase; Region: Obg; cd01898 441620013362 G1 box; other site 441620013363 GTP/Mg2+ binding site [chemical binding]; other site 441620013364 Switch I region; other site 441620013365 G2 box; other site 441620013366 G3 box; other site 441620013367 Switch II region; other site 441620013368 G4 box; other site 441620013369 G5 box; other site 441620013370 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 441620013371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 441620013372 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 441620013373 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 441620013374 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 441620013375 Pirin-related protein [General function prediction only]; Region: COG1741 441620013376 Pirin; Region: Pirin; pfam02678 441620013377 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 441620013378 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 441620013379 Putative hemolysin [General function prediction only]; Region: COG3176 441620013380 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 441620013381 nucleophile elbow; other site 441620013382 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 441620013383 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 441620013384 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 441620013385 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 441620013386 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 441620013387 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 441620013388 active site 441620013389 metal binding site [ion binding]; metal-binding site 441620013390 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 441620013391 Na binding site [ion binding]; other site 441620013392 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 441620013393 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 441620013394 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620013395 putative active site [active] 441620013396 heme pocket [chemical binding]; other site 441620013397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620013398 dimer interface [polypeptide binding]; other site 441620013399 phosphorylation site [posttranslational modification] 441620013400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620013401 ATP binding site [chemical binding]; other site 441620013402 Mg2+ binding site [ion binding]; other site 441620013403 G-X-G motif; other site 441620013404 Response regulator receiver domain; Region: Response_reg; pfam00072 441620013405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620013406 active site 441620013407 phosphorylation site [posttranslational modification] 441620013408 intermolecular recognition site; other site 441620013409 dimerization interface [polypeptide binding]; other site 441620013410 tellurite resistance protein terB; Region: terB; cd07176 441620013411 putative metal binding site [ion binding]; other site 441620013412 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 441620013413 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 441620013414 Substrate binding site; other site 441620013415 metal-binding site 441620013416 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 441620013417 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 441620013418 Phosphotransferase enzyme family; Region: APH; pfam01636 441620013419 PAS fold; Region: PAS_7; pfam12860 441620013420 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 441620013421 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620013422 dimer interface [polypeptide binding]; other site 441620013423 phosphorylation site [posttranslational modification] 441620013424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620013425 ATP binding site [chemical binding]; other site 441620013426 Mg2+ binding site [ion binding]; other site 441620013427 G-X-G motif; other site 441620013428 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 441620013429 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 441620013430 homotetramer interface [polypeptide binding]; other site 441620013431 ligand binding site [chemical binding]; other site 441620013432 catalytic site [active] 441620013433 NAD binding site [chemical binding]; other site 441620013434 Protein of unknown function (DUF433); Region: DUF433; pfam04255 441620013435 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 441620013436 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441620013437 acyl-activating enzyme (AAE) consensus motif; other site 441620013438 AMP binding site [chemical binding]; other site 441620013439 active site 441620013440 CoA binding site [chemical binding]; other site 441620013441 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 441620013442 putative FMN binding site [chemical binding]; other site 441620013443 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 441620013444 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 441620013445 enoyl-CoA hydratase; Validated; Region: PRK08139 441620013446 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 441620013447 substrate binding site [chemical binding]; other site 441620013448 oxyanion hole (OAH) forming residues; other site 441620013449 trimer interface [polypeptide binding]; other site 441620013450 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 441620013451 putative catalytic site [active] 441620013452 putative metal binding site [ion binding]; other site 441620013453 putative phosphate binding site [ion binding]; other site 441620013454 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 441620013455 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 441620013456 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 441620013457 putative active site [active] 441620013458 catalytic site [active] 441620013459 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 441620013460 putative active site [active] 441620013461 catalytic site [active] 441620013462 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 441620013463 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 441620013464 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 441620013465 Family description; Region: UvrD_C_2; pfam13538 441620013466 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 441620013467 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 441620013468 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 441620013469 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 441620013470 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 441620013471 catalytic residues [active] 441620013472 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 441620013473 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441620013474 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 441620013475 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 441620013476 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 441620013477 substrate binding site [chemical binding]; other site 441620013478 active site 441620013479 catalytic residues [active] 441620013480 heterodimer interface [polypeptide binding]; other site 441620013481 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 441620013482 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 441620013483 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 441620013484 putative NADH binding site [chemical binding]; other site 441620013485 putative active site [active] 441620013486 nudix motif; other site 441620013487 putative metal binding site [ion binding]; other site 441620013488 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 441620013489 nucleotide binding site/active site [active] 441620013490 HIT family signature motif; other site 441620013491 catalytic residue [active] 441620013492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 441620013493 active site 441620013494 dimerization interface [polypeptide binding]; other site 441620013495 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441620013496 Zn2+ binding site [ion binding]; other site 441620013497 Mg2+ binding site [ion binding]; other site 441620013498 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 441620013499 DEAD-like helicases superfamily; Region: DEXDc; smart00487 441620013500 ATP binding site [chemical binding]; other site 441620013501 putative Mg++ binding site [ion binding]; other site 441620013502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441620013503 nucleotide binding region [chemical binding]; other site 441620013504 ATP-binding site [chemical binding]; other site 441620013505 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 441620013506 RNA binding site [nucleotide binding]; other site 441620013507 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441620013508 dimerization interface [polypeptide binding]; other site 441620013509 Histidine kinase; Region: HisKA_3; pfam07730 441620013510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620013511 ATP binding site [chemical binding]; other site 441620013512 G-X-G motif; other site 441620013513 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441620013514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620013515 active site 441620013516 phosphorylation site [posttranslational modification] 441620013517 intermolecular recognition site; other site 441620013518 dimerization interface [polypeptide binding]; other site 441620013519 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441620013520 DNA binding residues [nucleotide binding] 441620013521 dimerization interface [polypeptide binding]; other site 441620013522 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 441620013523 amino acid transporter; Region: 2A0306; TIGR00909 441620013524 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 441620013525 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 441620013526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 441620013527 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441620013528 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441620013529 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 441620013530 Walker A/P-loop; other site 441620013531 ATP binding site [chemical binding]; other site 441620013532 Q-loop/lid; other site 441620013533 ABC transporter signature motif; other site 441620013534 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 441620013535 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 441620013536 putative active site [active] 441620013537 putative dimer interface [polypeptide binding]; other site 441620013538 RNA polymerase sigma factor; Provisional; Region: PRK12547 441620013539 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441620013540 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441620013541 DNA binding residues [nucleotide binding] 441620013542 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 441620013543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 441620013544 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 441620013545 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441620013546 catalytic loop [active] 441620013547 iron binding site [ion binding]; other site 441620013548 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 441620013549 putative binding surface; other site 441620013550 active site 441620013551 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441620013552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620013553 non-specific DNA binding site [nucleotide binding]; other site 441620013554 salt bridge; other site 441620013555 sequence-specific DNA binding site [nucleotide binding]; other site 441620013556 Cupin domain; Region: Cupin_2; pfam07883 441620013557 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 441620013558 dimer interface [polypeptide binding]; other site 441620013559 substrate binding site [chemical binding]; other site 441620013560 ATP binding site [chemical binding]; other site 441620013561 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 441620013562 active site 441620013563 thiamine phosphate binding site [chemical binding]; other site 441620013564 pyrophosphate binding site [ion binding]; other site 441620013565 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 441620013566 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 441620013567 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 441620013568 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 441620013569 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 441620013570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620013571 S-adenosylmethionine binding site [chemical binding]; other site 441620013572 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 441620013573 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 441620013574 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 441620013575 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 441620013576 active site 441620013577 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 441620013578 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 441620013579 Low molecular weight phosphatase family; Region: LMWPc; cd00115 441620013580 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 441620013581 active site 441620013582 Fructosamine kinase; Region: Fructosamin_kin; cl17579 441620013583 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441620013584 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 441620013585 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 441620013586 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 441620013587 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 441620013588 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 441620013589 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 441620013590 putative C-terminal domain interface [polypeptide binding]; other site 441620013591 putative GSH binding site (G-site) [chemical binding]; other site 441620013592 putative dimer interface [polypeptide binding]; other site 441620013593 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 441620013594 putative N-terminal domain interface [polypeptide binding]; other site 441620013595 putative dimer interface [polypeptide binding]; other site 441620013596 putative substrate binding pocket (H-site) [chemical binding]; other site 441620013597 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620013598 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620013599 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 441620013600 putative effector binding pocket; other site 441620013601 putative dimerization interface [polypeptide binding]; other site 441620013602 sulfite reductase; Provisional; Region: PRK06214 441620013603 Putative Fe-S cluster; Region: FeS; cl17515 441620013604 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 441620013605 FAD binding pocket [chemical binding]; other site 441620013606 FAD binding motif [chemical binding]; other site 441620013607 catalytic residues [active] 441620013608 NAD binding pocket [chemical binding]; other site 441620013609 phosphate binding motif [ion binding]; other site 441620013610 beta-alpha-beta structure motif; other site 441620013611 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 441620013612 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 441620013613 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 441620013614 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 441620013615 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441620013616 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441620013617 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441620013618 Walker A/P-loop; other site 441620013619 ATP binding site [chemical binding]; other site 441620013620 Q-loop/lid; other site 441620013621 ABC transporter signature motif; other site 441620013622 Walker B; other site 441620013623 D-loop; other site 441620013624 H-loop/switch region; other site 441620013625 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 441620013626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620013627 putative PBP binding loops; other site 441620013628 dimer interface [polypeptide binding]; other site 441620013629 ABC-ATPase subunit interface; other site 441620013630 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 441620013631 NMT1-like family; Region: NMT1_2; pfam13379 441620013632 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 441620013633 NMT1-like family; Region: NMT1_2; pfam13379 441620013634 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 441620013635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 441620013636 active site 441620013637 phosphorylation site [posttranslational modification] 441620013638 intermolecular recognition site; other site 441620013639 ANTAR domain; Region: ANTAR; pfam03861 441620013640 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 441620013641 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 441620013642 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 441620013643 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 441620013644 TPP-binding site [chemical binding]; other site 441620013645 dimer interface [polypeptide binding]; other site 441620013646 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 441620013647 PYR/PP interface [polypeptide binding]; other site 441620013648 dimer interface [polypeptide binding]; other site 441620013649 TPP binding site [chemical binding]; other site 441620013650 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 441620013651 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 441620013652 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 441620013653 putative active site [active] 441620013654 catalytic residue [active] 441620013655 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 441620013656 active site 441620013657 dimer interface [polypeptide binding]; other site 441620013658 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 441620013659 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 441620013660 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 441620013661 PAS domain; Region: PAS_9; pfam13426 441620013662 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620013663 putative active site [active] 441620013664 heme pocket [chemical binding]; other site 441620013665 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441620013666 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620013667 dimer interface [polypeptide binding]; other site 441620013668 putative CheW interface [polypeptide binding]; other site 441620013669 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441620013670 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 441620013671 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441620013672 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620013673 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620013674 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 441620013675 active site residue [active] 441620013676 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441620013677 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 441620013678 Autoinducer synthetase; Region: Autoind_synth; cl17404 441620013679 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 441620013680 Autoinducer binding domain; Region: Autoind_bind; pfam03472 441620013681 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441620013682 DNA binding residues [nucleotide binding] 441620013683 dimerization interface [polypeptide binding]; other site 441620013684 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620013685 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620013686 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 441620013687 putative substrate binding pocket [chemical binding]; other site 441620013688 putative dimerization interface [polypeptide binding]; other site 441620013689 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 441620013690 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 441620013691 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 441620013692 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 441620013693 Trp docking motif [polypeptide binding]; other site 441620013694 active site 441620013695 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620013696 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 441620013697 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620013698 Histidine kinase; Region: HisKA_2; pfam07568 441620013699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620013700 ATP binding site [chemical binding]; other site 441620013701 Mg2+ binding site [ion binding]; other site 441620013702 G-X-G motif; other site 441620013703 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 441620013704 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441620013705 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441620013706 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441620013707 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441620013708 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 441620013709 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441620013710 catalytic loop [active] 441620013711 iron binding site [ion binding]; other site 441620013712 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441620013713 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 441620013714 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 441620013715 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 441620013716 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 441620013717 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 441620013718 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 441620013719 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 441620013720 Protein of unknown function, DUF606; Region: DUF606; pfam04657 441620013721 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620013722 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620013723 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 441620013724 dimerization interface [polypeptide binding]; other site 441620013725 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 441620013726 Enoylreductase; Region: PKS_ER; smart00829 441620013727 NAD(P) binding site [chemical binding]; other site 441620013728 PAS fold; Region: PAS_4; pfam08448 441620013729 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620013730 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 441620013731 PAS domain S-box; Region: sensory_box; TIGR00229 441620013732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620013733 putative active site [active] 441620013734 heme pocket [chemical binding]; other site 441620013735 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620013736 GAF domain; Region: GAF; pfam01590 441620013737 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620013738 PAS fold; Region: PAS_3; pfam08447 441620013739 putative active site [active] 441620013740 heme pocket [chemical binding]; other site 441620013741 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620013742 HWE histidine kinase; Region: HWE_HK; smart00911 441620013743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620013744 active site 441620013745 phosphorylation site [posttranslational modification] 441620013746 intermolecular recognition site; other site 441620013747 dimerization interface [polypeptide binding]; other site 441620013748 Bacterial SH3 domain; Region: SH3_3; pfam08239 441620013749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620013750 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 441620013751 NAD(P) binding site [chemical binding]; other site 441620013752 active site 441620013753 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 441620013754 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 441620013755 dimer interface [polypeptide binding]; other site 441620013756 active site 441620013757 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 441620013758 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 441620013759 active site 441620013760 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 441620013761 active site 2 [active] 441620013762 active site 1 [active] 441620013763 acyl carrier protein; Provisional; Region: PRK06508 441620013764 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441620013765 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441620013766 metal binding site [ion binding]; metal-binding site 441620013767 active site 441620013768 I-site; other site 441620013769 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 441620013770 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 441620013771 Transposase, Mutator family; Region: Transposase_mut; pfam00872 441620013772 MULE transposase domain; Region: MULE; pfam10551 441620013773 Cupin domain; Region: Cupin_2; cl17218 441620013774 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 441620013775 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 441620013776 putative dimer interface [polypeptide binding]; other site 441620013777 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 441620013778 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 441620013779 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 441620013780 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 441620013781 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 441620013782 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 441620013783 active site 441620013784 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 441620013785 Domain of unknown function DUF20; Region: UPF0118; pfam01594 441620013786 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 441620013787 putative active site [active] 441620013788 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 441620013789 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 441620013790 active site 441620013791 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 441620013792 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 441620013793 Domain of unknown function DUF59; Region: DUF59; pfam01883 441620013794 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 441620013795 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441620013796 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 441620013797 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 441620013798 GTP binding site; other site 441620013799 DNA gyrase subunit A; Validated; Region: PRK05560 441620013800 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 441620013801 CAP-like domain; other site 441620013802 active site 441620013803 primary dimer interface [polypeptide binding]; other site 441620013804 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441620013805 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441620013806 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441620013807 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441620013808 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441620013809 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 441620013810 GIY-YIG motif/motif A; other site 441620013811 putative active site [active] 441620013812 putative metal binding site [ion binding]; other site 441620013813 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 441620013814 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 441620013815 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 441620013816 active site 441620013817 (T/H)XGH motif; other site 441620013818 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 441620013819 active site 441620013820 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 441620013821 active site 441620013822 Response regulator receiver domain; Region: Response_reg; pfam00072 441620013823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620013824 active site 441620013825 phosphorylation site [posttranslational modification] 441620013826 intermolecular recognition site; other site 441620013827 dimerization interface [polypeptide binding]; other site 441620013828 Uncharacterized conserved protein [Function unknown]; Region: COG4544 441620013829 DNA Polymerase Y-family; Region: PolY_like; cd03468 441620013830 active site 441620013831 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 441620013832 DNA binding site [nucleotide binding] 441620013833 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 441620013834 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 441620013835 putative active site [active] 441620013836 putative PHP Thumb interface [polypeptide binding]; other site 441620013837 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 441620013838 generic binding surface II; other site 441620013839 generic binding surface I; other site 441620013840 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441620013841 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441620013842 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 441620013843 Predicted membrane protein [Function unknown]; Region: COG4125 441620013844 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 441620013845 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 441620013846 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 441620013847 Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism]; Region: MnhC; COG1006 441620013848 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 441620013849 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 441620013850 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 441620013851 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 441620013852 active site 441620013853 nucleophile elbow; other site 441620013854 Patatin phospholipase; Region: DUF3734; pfam12536 441620013855 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 441620013856 O-Antigen ligase; Region: Wzy_C; pfam04932 441620013857 Right handed beta helix region; Region: Beta_helix; pfam13229 441620013858 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 441620013859 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 441620013860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620013861 PAS domain; Region: PAS_9; pfam13426 441620013862 putative active site [active] 441620013863 heme pocket [chemical binding]; other site 441620013864 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 441620013865 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 441620013866 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 441620013867 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 441620013868 alpha-gamma subunit interface [polypeptide binding]; other site 441620013869 beta-gamma subunit interface [polypeptide binding]; other site 441620013870 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 441620013871 alpha-beta subunit interface [polypeptide binding]; other site 441620013872 urease subunit alpha; Reviewed; Region: ureC; PRK13207 441620013873 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 441620013874 subunit interactions [polypeptide binding]; other site 441620013875 active site 441620013876 flap region; other site 441620013877 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 441620013878 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636 441620013879 urease accessory protein UreE; Provisional; Region: ureE; PRK13262 441620013880 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 441620013881 dimer interface [polypeptide binding]; other site 441620013882 catalytic residues [active] 441620013883 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 441620013884 UreF; Region: UreF; pfam01730 441620013885 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441620013886 UreD urease accessory protein; Region: UreD; pfam01774 441620013887 Urea transporter; Region: UT; cl01829 441620013888 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 441620013889 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 441620013890 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 441620013891 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 441620013892 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 441620013893 protein binding site [polypeptide binding]; other site 441620013894 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 441620013895 acid-resistance protein; Provisional; Region: PRK10208 441620013896 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 441620013897 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 441620013898 Cl- selectivity filter; other site 441620013899 Cl- binding residues [ion binding]; other site 441620013900 pore gating glutamate residue; other site 441620013901 dimer interface [polypeptide binding]; other site 441620013902 H+/Cl- coupling transport residue; other site 441620013903 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 441620013904 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441620013905 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620013906 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 441620013907 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 441620013908 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 441620013909 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 441620013910 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 441620013911 catalytic residues [active] 441620013912 catalytic nucleophile [active] 441620013913 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 441620013914 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 441620013915 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 441620013916 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 441620013917 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 441620013918 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 441620013919 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 441620013920 ATP binding site [chemical binding]; other site 441620013921 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 441620013922 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 441620013923 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 441620013924 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 441620013925 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 441620013926 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 441620013927 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 441620013928 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 441620013929 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 441620013930 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 441620013931 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 441620013932 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 441620013933 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 441620013934 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 441620013935 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 441620013936 NADP binding site [chemical binding]; other site 441620013937 active site 441620013938 putative substrate binding site [chemical binding]; other site 441620013939 Condensation domain; Region: Condensation; pfam00668 441620013940 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 441620013941 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 441620013942 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 441620013943 Condensation domain; Region: Condensation; pfam00668 441620013944 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 441620013945 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 441620013946 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 441620013947 acyl-activating enzyme (AAE) consensus motif; other site 441620013948 AMP binding site [chemical binding]; other site 441620013949 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 441620013950 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 441620013951 catalytic core [active] 441620013952 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 441620013953 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 441620013954 active site 441620013955 catalytic tetrad [active] 441620013956 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 441620013957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620013958 Walker A motif; other site 441620013959 ATP binding site [chemical binding]; other site 441620013960 Walker B motif; other site 441620013961 arginine finger; other site 441620013962 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 441620013963 oligomeric interface; other site 441620013964 putative active site [active] 441620013965 homodimer interface [polypeptide binding]; other site 441620013966 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441620013967 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 441620013968 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 441620013969 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 441620013970 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 441620013971 TrkA-N domain; Region: TrkA_N; pfam02254 441620013972 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 441620013973 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441620013974 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441620013975 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 441620013976 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 441620013977 Mg++ binding site [ion binding]; other site 441620013978 putative catalytic motif [active] 441620013979 putative substrate binding site [chemical binding]; other site 441620013980 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 441620013981 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 441620013982 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441620013983 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441620013984 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 441620013985 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441620013986 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441620013987 penicillin-binding protein 2; Provisional; Region: PRK10795 441620013988 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 441620013989 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 441620013990 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 441620013991 MraW methylase family; Region: Methyltransf_5; cl17771 441620013992 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 441620013993 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 441620013994 Ligase N family; Region: LIGANc; smart00532 441620013995 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 441620013996 nucleotide binding pocket [chemical binding]; other site 441620013997 K-X-D-G motif; other site 441620013998 catalytic site [active] 441620013999 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 441620014000 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 441620014001 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 441620014002 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 441620014003 Dimer interface [polypeptide binding]; other site 441620014004 BRCT sequence motif; other site 441620014005 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 441620014006 putative active site [active] 441620014007 adenosine kinase; Provisional; Region: PTZ00247 441620014008 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 441620014009 substrate binding site [chemical binding]; other site 441620014010 ATP binding site [chemical binding]; other site 441620014011 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 441620014012 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 441620014013 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 441620014014 CoA-transferase family III; Region: CoA_transf_3; pfam02515 441620014015 enoyl-CoA hydratase; Provisional; Region: PRK06144 441620014016 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 441620014017 substrate binding site [chemical binding]; other site 441620014018 oxyanion hole (OAH) forming residues; other site 441620014019 trimer interface [polypeptide binding]; other site 441620014020 Transcriptional regulators [Transcription]; Region: FadR; COG2186 441620014021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441620014022 DNA-binding site [nucleotide binding]; DNA binding site 441620014023 FCD domain; Region: FCD; pfam07729 441620014024 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 441620014025 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 441620014026 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441620014027 catalytic residue [active] 441620014028 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 441620014029 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 441620014030 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 441620014031 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 441620014032 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 441620014033 DNA polymerase III subunit chi; Validated; Region: PRK05728 441620014034 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 441620014035 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 441620014036 Predicted membrane protein [Function unknown]; Region: COG3766 441620014037 CTP synthetase; Validated; Region: pyrG; PRK05380 441620014038 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 441620014039 Catalytic site [active] 441620014040 active site 441620014041 UTP binding site [chemical binding]; other site 441620014042 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 441620014043 active site 441620014044 putative oxyanion hole; other site 441620014045 catalytic triad [active] 441620014046 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 441620014047 catalytic triad [active] 441620014048 conserved cis-peptide bond; other site 441620014049 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 441620014050 triosephosphate isomerase; Provisional; Region: PRK14565 441620014051 substrate binding site [chemical binding]; other site 441620014052 dimer interface [polypeptide binding]; other site 441620014053 catalytic triad [active] 441620014054 periplasmic folding chaperone; Provisional; Region: PRK10788 441620014055 SurA N-terminal domain; Region: SurA_N_3; cl07813 441620014056 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 441620014057 anthranilate synthase component I; Provisional; Region: PRK13573 441620014058 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 441620014059 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 441620014060 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 441620014061 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441620014062 dimerization interface [polypeptide binding]; other site 441620014063 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620014064 dimer interface [polypeptide binding]; other site 441620014065 putative CheW interface [polypeptide binding]; other site 441620014066 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 441620014067 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 441620014068 glutamine binding [chemical binding]; other site 441620014069 catalytic triad [active] 441620014070 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 441620014071 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 441620014072 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 441620014073 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 441620014074 active site 441620014075 ribulose/triose binding site [chemical binding]; other site 441620014076 phosphate binding site [ion binding]; other site 441620014077 substrate (anthranilate) binding pocket [chemical binding]; other site 441620014078 product (indole) binding pocket [chemical binding]; other site 441620014079 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 441620014080 trimer interface [polypeptide binding]; other site 441620014081 dimer interface [polypeptide binding]; other site 441620014082 putative active site [active] 441620014083 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 441620014084 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 441620014085 dimer interface [polypeptide binding]; other site 441620014086 putative functional site; other site 441620014087 putative MPT binding site; other site 441620014088 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 441620014089 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620014090 salt bridge; other site 441620014091 non-specific DNA binding site [nucleotide binding]; other site 441620014092 sequence-specific DNA binding site [nucleotide binding]; other site 441620014093 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 441620014094 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 441620014095 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 441620014096 active site 441620014097 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 441620014098 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 441620014099 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 441620014100 hypothetical protein; Validated; Region: PRK00124 441620014101 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 441620014102 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 441620014103 dimer interface [polypeptide binding]; other site 441620014104 active site 441620014105 citrylCoA binding site [chemical binding]; other site 441620014106 NADH binding [chemical binding]; other site 441620014107 cationic pore residues; other site 441620014108 oxalacetate/citrate binding site [chemical binding]; other site 441620014109 coenzyme A binding site [chemical binding]; other site 441620014110 catalytic triad [active] 441620014111 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 441620014112 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 441620014113 active site 441620014114 HIGH motif; other site 441620014115 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 441620014116 active site 441620014117 KMSKS motif; other site 441620014118 Competence protein; Region: Competence; pfam03772 441620014119 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 441620014120 LexA repressor; Validated; Region: PRK00215 441620014121 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 441620014122 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 441620014123 Catalytic site [active] 441620014124 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 441620014125 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 441620014126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620014127 putative substrate translocation pore; other site 441620014128 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 441620014129 tartrate dehydrogenase; Region: TTC; TIGR02089 441620014130 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 441620014131 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 441620014132 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 441620014133 active site 441620014134 catalytic tetrad [active] 441620014135 HAMP domain; Region: HAMP; pfam00672 441620014136 dimerization interface [polypeptide binding]; other site 441620014137 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620014138 dimer interface [polypeptide binding]; other site 441620014139 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 441620014140 putative CheW interface [polypeptide binding]; other site 441620014141 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 441620014142 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 441620014143 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 441620014144 protein binding site [polypeptide binding]; other site 441620014145 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 441620014146 protein binding site [polypeptide binding]; other site 441620014147 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 441620014148 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 441620014149 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441620014150 active site 441620014151 HIGH motif; other site 441620014152 nucleotide binding site [chemical binding]; other site 441620014153 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 441620014154 active site 441620014155 KMSKS motif; other site 441620014156 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 441620014157 tRNA binding surface [nucleotide binding]; other site 441620014158 anticodon binding site; other site 441620014159 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 441620014160 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 441620014161 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 441620014162 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 441620014163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620014164 S-adenosylmethionine binding site [chemical binding]; other site 441620014165 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 441620014166 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 441620014167 putative substrate binding site [chemical binding]; other site 441620014168 putative ATP binding site [chemical binding]; other site 441620014169 PBP superfamily domain; Region: PBP_like_2; cl17296 441620014170 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 441620014171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620014172 dimer interface [polypeptide binding]; other site 441620014173 conserved gate region; other site 441620014174 putative PBP binding loops; other site 441620014175 ABC-ATPase subunit interface; other site 441620014176 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 441620014177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441620014178 dimer interface [polypeptide binding]; other site 441620014179 conserved gate region; other site 441620014180 putative PBP binding loops; other site 441620014181 ABC-ATPase subunit interface; other site 441620014182 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 441620014183 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 441620014184 Walker A/P-loop; other site 441620014185 ATP binding site [chemical binding]; other site 441620014186 Q-loop/lid; other site 441620014187 ABC transporter signature motif; other site 441620014188 Walker B; other site 441620014189 D-loop; other site 441620014190 H-loop/switch region; other site 441620014191 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 441620014192 PhoU domain; Region: PhoU; pfam01895 441620014193 PhoU domain; Region: PhoU; pfam01895 441620014194 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 441620014195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620014196 active site 441620014197 phosphorylation site [posttranslational modification] 441620014198 intermolecular recognition site; other site 441620014199 dimerization interface [polypeptide binding]; other site 441620014200 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441620014201 DNA binding site [nucleotide binding] 441620014202 GcrA cell cycle regulator; Region: GcrA; cl11564 441620014203 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 441620014204 DNA polymerase IV; Provisional; Region: PRK02794 441620014205 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 441620014206 active site 441620014207 DNA binding site [nucleotide binding] 441620014208 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 441620014209 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 441620014210 cobyric acid synthase; Provisional; Region: PRK00784 441620014211 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441620014212 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 441620014213 catalytic triad [active] 441620014214 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 441620014215 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 441620014216 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 441620014217 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441620014218 catalytic residue [active] 441620014219 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 441620014220 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 441620014221 CsbD-like; Region: CsbD; pfam05532 441620014222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441620014223 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 441620014224 NAD(P) binding site [chemical binding]; other site 441620014225 active site 441620014226 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 441620014227 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 441620014228 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 441620014229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 441620014230 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 441620014231 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 441620014232 active site 441620014233 NTP binding site [chemical binding]; other site 441620014234 metal binding triad [ion binding]; metal-binding site 441620014235 antibiotic binding site [chemical binding]; other site 441620014236 HEPN domain; Region: HEPN; cl00824 441620014237 Transglycosylase SLT domain; Region: SLT_2; pfam13406 441620014238 murein hydrolase B; Provisional; Region: PRK10760; cl17906 441620014239 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441620014240 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 441620014241 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 441620014242 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441620014243 RNA binding surface [nucleotide binding]; other site 441620014244 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 441620014245 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 441620014246 FMN binding site [chemical binding]; other site 441620014247 substrate binding site [chemical binding]; other site 441620014248 putative catalytic residue [active] 441620014249 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 441620014250 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 441620014251 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 441620014252 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441620014253 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 441620014254 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 441620014255 Walker A/P-loop; other site 441620014256 ATP binding site [chemical binding]; other site 441620014257 Q-loop/lid; other site 441620014258 ABC transporter signature motif; other site 441620014259 Walker B; other site 441620014260 D-loop; other site 441620014261 H-loop/switch region; other site 441620014262 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441620014263 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 441620014264 Methyltransferase domain; Region: Methyltransf_24; pfam13578 441620014265 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 441620014266 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441620014267 active site 441620014268 HIGH motif; other site 441620014269 nucleotide binding site [chemical binding]; other site 441620014270 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 441620014271 KMSKS motif; other site 441620014272 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 441620014273 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 441620014274 CreA protein; Region: CreA; pfam05981 441620014275 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 441620014276 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 441620014277 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 441620014278 ligand binding site [chemical binding]; other site 441620014279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620014280 putative substrate translocation pore; other site 441620014281 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441620014282 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 441620014283 dimer interface [polypeptide binding]; other site 441620014284 Methyltransferase domain; Region: Methyltransf_31; pfam13847 441620014285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620014286 S-adenosylmethionine binding site [chemical binding]; other site 441620014287 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 441620014288 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441620014289 active site 441620014290 HIGH motif; other site 441620014291 nucleotide binding site [chemical binding]; other site 441620014292 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 441620014293 active site 441620014294 KMSKS motif; other site 441620014295 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 441620014296 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 441620014297 HlyD family secretion protein; Region: HlyD_3; pfam13437 441620014298 Fusaric acid resistance protein family; Region: FUSC; pfam04632 441620014299 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 441620014300 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 441620014301 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 441620014302 C-terminal domain interface [polypeptide binding]; other site 441620014303 GSH binding site (G-site) [chemical binding]; other site 441620014304 dimer interface [polypeptide binding]; other site 441620014305 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 441620014306 N-terminal domain interface [polypeptide binding]; other site 441620014307 putative dimer interface [polypeptide binding]; other site 441620014308 active site 441620014309 translocation protein TolB; Provisional; Region: tolB; PRK05137 441620014310 TolB amino-terminal domain; Region: TolB_N; pfam04052 441620014311 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 441620014312 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 441620014313 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 441620014314 TolA protein; Region: tolA_full; TIGR02794 441620014315 TolR protein; Region: tolR; TIGR02801 441620014316 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 441620014317 TolQ protein; Region: tolQ; TIGR02796 441620014318 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620014319 dimer interface [polypeptide binding]; other site 441620014320 putative CheW interface [polypeptide binding]; other site 441620014321 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 441620014322 active site 441620014323 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 441620014324 Domain of unknown function (DUF4142); Region: DUF4142; cl17876 441620014325 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 441620014326 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 441620014327 putative active site [active] 441620014328 putative metal binding site [ion binding]; other site 441620014329 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 441620014330 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 441620014331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620014332 Walker A motif; other site 441620014333 ATP binding site [chemical binding]; other site 441620014334 Walker B motif; other site 441620014335 arginine finger; other site 441620014336 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 441620014337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 441620014338 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441620014339 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441620014340 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 441620014341 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 441620014342 dimerization interface [polypeptide binding]; other site 441620014343 DPS ferroxidase diiron center [ion binding]; other site 441620014344 ion pore; other site 441620014345 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 441620014346 CoA binding domain; Region: CoA_binding_2; pfam13380 441620014347 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 441620014348 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 441620014349 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 441620014350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441620014351 Coenzyme A binding pocket [chemical binding]; other site 441620014352 intersubunit interface [polypeptide binding]; other site 441620014353 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 441620014354 active site 441620014355 Zn2+ binding site [ion binding]; other site 441620014356 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 441620014357 Restriction endonuclease; Region: Mrr_cat; pfam04471 441620014358 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 441620014359 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 441620014360 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 441620014361 Transglycosylase; Region: Transgly; pfam00912 441620014362 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 441620014363 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 441620014364 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 441620014365 cyclase homology domain; Region: CHD; cd07302 441620014366 nucleotidyl binding site; other site 441620014367 metal binding site [ion binding]; metal-binding site 441620014368 dimer interface [polypeptide binding]; other site 441620014369 MAPEG family; Region: MAPEG; cl09190 441620014370 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 441620014371 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 441620014372 P-loop; other site 441620014373 Magnesium ion binding site [ion binding]; other site 441620014374 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441620014375 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 441620014376 homotrimer interaction site [polypeptide binding]; other site 441620014377 putative active site [active] 441620014378 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 441620014379 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 441620014380 ring oligomerisation interface [polypeptide binding]; other site 441620014381 ATP/Mg binding site [chemical binding]; other site 441620014382 stacking interactions; other site 441620014383 hinge regions; other site 441620014384 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 441620014385 oligomerisation interface [polypeptide binding]; other site 441620014386 mobile loop; other site 441620014387 roof hairpin; other site 441620014388 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 441620014389 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 441620014390 Cl binding site [ion binding]; other site 441620014391 oligomer interface [polypeptide binding]; other site 441620014392 MarC family integral membrane protein; Region: MarC; cl00919 441620014393 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 441620014394 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 441620014395 FAD binding domain; Region: FAD_binding_4; pfam01565 441620014396 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 441620014397 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 441620014398 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 441620014399 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 441620014400 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 441620014401 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 441620014402 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 441620014403 Substrate binding site; other site 441620014404 Cupin domain; Region: Cupin_2; cl17218 441620014405 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 441620014406 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 441620014407 active site 441620014408 substrate binding site [chemical binding]; other site 441620014409 coenzyme B12 binding site [chemical binding]; other site 441620014410 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 441620014411 B12 binding site [chemical binding]; other site 441620014412 cobalt ligand [ion binding]; other site 441620014413 Protein of unknown function (DUF817); Region: DUF817; pfam05675 441620014414 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 441620014415 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 441620014416 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 441620014417 protein binding site [polypeptide binding]; other site 441620014418 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 441620014419 HSP70 interaction site [polypeptide binding]; other site 441620014420 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 441620014421 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 441620014422 Sporulation related domain; Region: SPOR; pfam05036 441620014423 Uncharacterized conserved protein [Function unknown]; Region: COG2127 441620014424 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 441620014425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620014426 Walker A motif; other site 441620014427 ATP binding site [chemical binding]; other site 441620014428 Walker B motif; other site 441620014429 arginine finger; other site 441620014430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620014431 Walker A motif; other site 441620014432 ATP binding site [chemical binding]; other site 441620014433 Walker B motif; other site 441620014434 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 441620014435 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 441620014436 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 441620014437 HicB family; Region: HicB; pfam05534 441620014438 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 441620014439 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 441620014440 substrate-cofactor binding pocket; other site 441620014441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441620014442 catalytic residue [active] 441620014443 Protein of unknown function (DUF3623); Region: DUF3623; cl11843 441620014444 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 441620014445 diiron binding motif [ion binding]; other site 441620014446 putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054 441620014447 Bacterial PH domain; Region: DUF304; pfam03703 441620014448 photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150 441620014449 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581 441620014450 subunit C interaction residues; other site 441620014451 subunit M interaction residues [polypeptide binding]; other site 441620014452 subunit L interaction residues [polypeptide binding]; other site 441620014453 putative proton transfer pathway, P1; other site 441620014454 putative proton transfer pathway, P2; other site 441620014455 PUCC protein; Region: PUCC; pfam03209 441620014456 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 441620014457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441620014458 S-adenosylmethionine binding site [chemical binding]; other site 441620014459 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 441620014460 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 441620014461 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 441620014462 P-loop; other site 441620014463 magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405 441620014464 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 441620014465 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 441620014466 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 441620014467 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 441620014468 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 441620014469 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 441620014470 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 441620014471 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 441620014472 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 441620014473 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 441620014474 B12 binding site [chemical binding]; other site 441620014475 transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040 441620014476 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620014477 putative active site [active] 441620014478 heme pocket [chemical binding]; other site 441620014479 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 441620014480 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441620014481 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 441620014482 UbiA prenyltransferase family; Region: UbiA; pfam01040 441620014483 PUCC protein; Region: PUCC; pfam03209 441620014484 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 441620014485 TspO/MBR family; Region: TspO_MBR; pfam03073 441620014486 Cytochrome c; Region: Cytochrom_C; pfam00034 441620014487 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 441620014488 Cytochrome c; Region: Cytochrom_C; pfam00034 441620014489 Cytochrome c; Region: Cytochrom_C; pfam00034 441620014490 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 441620014491 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 441620014492 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 441620014493 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 441620014494 putative active site [active] 441620014495 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 441620014496 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441620014497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441620014498 Walker A/P-loop; other site 441620014499 ATP binding site [chemical binding]; other site 441620014500 Q-loop/lid; other site 441620014501 ABC transporter signature motif; other site 441620014502 Walker B; other site 441620014503 D-loop; other site 441620014504 H-loop/switch region; other site 441620014505 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 441620014506 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 441620014507 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 441620014508 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 441620014509 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 441620014510 ligand binding site [chemical binding]; other site 441620014511 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 441620014512 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 441620014513 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 441620014514 Mechanosensitive ion channel; Region: MS_channel; pfam00924 441620014515 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 441620014516 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 441620014517 active site 441620014518 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 441620014519 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 441620014520 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 441620014521 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 441620014522 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 441620014523 active site 441620014524 substrate binding site [chemical binding]; other site 441620014525 metal binding site [ion binding]; metal-binding site 441620014526 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 441620014527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441620014528 Walker A motif; other site 441620014529 ATP binding site [chemical binding]; other site 441620014530 Walker B motif; other site 441620014531 arginine finger; other site 441620014532 Peptidase family M41; Region: Peptidase_M41; pfam01434 441620014533 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 441620014534 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 441620014535 Ligand Binding Site [chemical binding]; other site 441620014536 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 441620014537 Tetratricopeptide repeat; Region: TPR_6; pfam13174 441620014538 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 441620014539 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 441620014540 ligand binding site [chemical binding]; other site 441620014541 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441620014542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620014543 active site 441620014544 phosphorylation site [posttranslational modification] 441620014545 intermolecular recognition site; other site 441620014546 dimerization interface [polypeptide binding]; other site 441620014547 GSCFA family; Region: GSCFA; pfam08885 441620014548 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 441620014549 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 441620014550 domain interfaces; other site 441620014551 active site 441620014552 Hint domain; Region: Hint_2; pfam13403 441620014553 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620014554 PAS fold; Region: PAS_3; pfam08447 441620014555 putative active site [active] 441620014556 heme pocket [chemical binding]; other site 441620014557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441620014558 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441620014559 non-specific DNA binding site [nucleotide binding]; other site 441620014560 salt bridge; other site 441620014561 sequence-specific DNA binding site [nucleotide binding]; other site 441620014562 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 441620014563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441620014564 putative substrate translocation pore; other site 441620014565 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 441620014566 dimerization interface [polypeptide binding]; other site 441620014567 metal binding site [ion binding]; metal-binding site 441620014568 hypothetical protein; Validated; Region: PRK00029 441620014569 Uncharacterized conserved protein [Function unknown]; Region: COG0397 441620014570 HAMP domain; Region: HAMP; pfam00672 441620014571 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441620014572 dimer interface [polypeptide binding]; other site 441620014573 putative CheW interface [polypeptide binding]; other site 441620014574 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 441620014575 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 441620014576 PYR/PP interface [polypeptide binding]; other site 441620014577 dimer interface [polypeptide binding]; other site 441620014578 TPP binding site [chemical binding]; other site 441620014579 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 441620014580 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 441620014581 TPP-binding site [chemical binding]; other site 441620014582 dimer interface [polypeptide binding]; other site 441620014583 Methyltransferase domain; Region: Methyltransf_23; pfam13489 441620014584 Methyltransferase domain; Region: Methyltransf_12; pfam08242 441620014585 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 441620014586 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 441620014587 putative valine binding site [chemical binding]; other site 441620014588 dimer interface [polypeptide binding]; other site 441620014589 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 441620014590 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 441620014591 PemK-like protein; Region: PemK; pfam02452 441620014592 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 441620014593 glutathionine S-transferase; Provisional; Region: PRK10542 441620014594 C-terminal domain interface [polypeptide binding]; other site 441620014595 GSH binding site (G-site) [chemical binding]; other site 441620014596 dimer interface [polypeptide binding]; other site 441620014597 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 441620014598 dimer interface [polypeptide binding]; other site 441620014599 substrate binding pocket (H-site) [chemical binding]; other site 441620014600 N-terminal domain interface [polypeptide binding]; other site 441620014601 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 441620014602 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 441620014603 active site 441620014604 dimer interface [polypeptide binding]; other site 441620014605 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 441620014606 Ligand Binding Site [chemical binding]; other site 441620014607 Molecular Tunnel; other site 441620014608 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 441620014609 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 441620014610 putative active site [active] 441620014611 putative dimer interface [polypeptide binding]; other site 441620014612 RNA polymerase sigma factor; Provisional; Region: PRK12546 441620014613 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441620014614 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441620014615 DNA binding residues [nucleotide binding] 441620014616 Response regulator receiver domain; Region: Response_reg; pfam00072 441620014617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620014618 active site 441620014619 phosphorylation site [posttranslational modification] 441620014620 intermolecular recognition site; other site 441620014621 dimerization interface [polypeptide binding]; other site 441620014622 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 441620014623 Histidine kinase; Region: HisKA_2; pfam07568 441620014624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620014625 ATP binding site [chemical binding]; other site 441620014626 Mg2+ binding site [ion binding]; other site 441620014627 G-X-G motif; other site 441620014628 Response regulator receiver domain; Region: Response_reg; pfam00072 441620014629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620014630 active site 441620014631 phosphorylation site [posttranslational modification] 441620014632 intermolecular recognition site; other site 441620014633 dimerization interface [polypeptide binding]; other site 441620014634 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 441620014635 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 441620014636 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 441620014637 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620014638 putative active site [active] 441620014639 PAS fold; Region: PAS_3; pfam08447 441620014640 heme pocket [chemical binding]; other site 441620014641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441620014642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441620014643 dimer interface [polypeptide binding]; other site 441620014644 phosphorylation site [posttranslational modification] 441620014645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441620014646 ATP binding site [chemical binding]; other site 441620014647 Mg2+ binding site [ion binding]; other site 441620014648 G-X-G motif; other site 441620014649 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441620014650 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441620014651 ligand binding site [chemical binding]; other site 441620014652 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 441620014653 putative switch regulator; other site 441620014654 non-specific DNA interactions [nucleotide binding]; other site 441620014655 DNA binding site [nucleotide binding] 441620014656 sequence specific DNA binding site [nucleotide binding]; other site 441620014657 putative cAMP binding site [chemical binding]; other site 441620014658 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441620014659 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 441620014660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620014661 PAS fold; Region: PAS_3; pfam08447 441620014662 putative active site [active] 441620014663 heme pocket [chemical binding]; other site 441620014664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441620014665 PAS fold; Region: PAS_3; pfam08447 441620014666 putative active site [active] 441620014667 heme pocket [chemical binding]; other site 441620014668 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 441620014669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441620014670 active site 441620014671 phosphorylation site [posttranslational modification] 441620014672 intermolecular recognition site; other site 441620014673 dimerization interface [polypeptide binding]; other site 441620014674 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441620014675 DNA binding residues [nucleotide binding] 441620014676 dimerization interface [polypeptide binding]; other site 441620014677 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 441620014678 Cytochrome P450; Region: p450; cl12078 441620014679 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 441620014680 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441620014681 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441620014682 DDE domain; Region: DDE_Tnp_IS240; pfam13610 441620014683 Integrase core domain; Region: rve; pfam00665 441620014684 Protein of unknown function, DUF417; Region: DUF417; cl01162 441620014685 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 441620014686 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 441620014687 catalytic residues [active] 441620014688 catalytic nucleophile [active] 441620014689 Presynaptic Site I dimer interface [polypeptide binding]; other site 441620014690 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 441620014691 Synaptic Flat tetramer interface [polypeptide binding]; other site 441620014692 Synaptic Site I dimer interface [polypeptide binding]; other site 441620014693 DNA binding site [nucleotide binding] 441620014694 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 441620014695 DNA-binding interface [nucleotide binding]; DNA binding site 441620014696 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 441620014697 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 441620014698 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 441620014699 IHF - DNA interface [nucleotide binding]; other site 441620014700 IHF dimer interface [polypeptide binding]; other site 441620014701 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 441620014702 active site 441620014703 metal binding site [ion binding]; metal-binding site 441620014704 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 441620014705 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 441620014706 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 441620014707 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441620014708 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 441620014709 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 441620014710 catalytic residues [active] 441620014711 catalytic nucleophile [active] 441620014712 Presynaptic Site I dimer interface [polypeptide binding]; other site 441620014713 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 441620014714 Synaptic Flat tetramer interface [polypeptide binding]; other site 441620014715 Synaptic Site I dimer interface [polypeptide binding]; other site 441620014716 DNA binding site [nucleotide binding] 441620014717 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 441620014718 DNA-binding interface [nucleotide binding]; DNA binding site 441620014719 DDE domain; Region: DDE_Tnp_IS240; pfam13610 441620014720 Integrase core domain; Region: rve; pfam00665 441620014721 DinB superfamily; Region: DinB_2; pfam12867 441620014722 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 441620014723 putative glycosyltransferase, TIGR04348 family; Region: TIGR04348 441620014724 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441620014725 Uncharacterized conserved protein [Function unknown]; Region: COG3025 441620014726 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 441620014727 putative active site [active] 441620014728 putative metal binding residues [ion binding]; other site 441620014729 signature motif; other site 441620014730 putative triphosphate binding site [ion binding]; other site 441620014731 CHAD domain; Region: CHAD; pfam05235 441620014732 Transposase, Mutator family; Region: Transposase_mut; pfam00872 441620014733 MULE transposase domain; Region: MULE; pfam10551