-- dump date 20140619_144750 -- class Genbank::misc_feature -- table misc_feature_note -- id note 426355000001 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355000002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 426355000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355000004 Walker A motif; other site 426355000005 ATP binding site [chemical binding]; other site 426355000006 Walker B motif; other site 426355000007 Transposase; Region: HTH_Tnp_1; cl17663 426355000008 putative transposase OrfB; Reviewed; Region: PHA02517 426355000009 HTH-like domain; Region: HTH_21; pfam13276 426355000010 Integrase core domain; Region: rve; pfam00665 426355000011 Integrase core domain; Region: rve_2; pfam13333 426355000012 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 426355000013 SprT-like family; Region: SprT-like; pfam10263 426355000014 SprT homologues; Region: SprT; cl01182 426355000015 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 426355000016 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426355000017 P-loop; other site 426355000018 Magnesium ion binding site [ion binding]; other site 426355000019 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 426355000020 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 426355000021 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 426355000022 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 426355000023 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 426355000024 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 426355000025 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 426355000026 putative active site [active] 426355000027 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 426355000028 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426355000029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355000030 Walker A/P-loop; other site 426355000031 ATP binding site [chemical binding]; other site 426355000032 Q-loop/lid; other site 426355000033 ABC transporter signature motif; other site 426355000034 Walker B; other site 426355000035 D-loop; other site 426355000036 H-loop/switch region; other site 426355000037 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 426355000038 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355000039 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426355000040 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 426355000041 catalytic residues [active] 426355000042 catalytic nucleophile [active] 426355000043 Presynaptic Site I dimer interface [polypeptide binding]; other site 426355000044 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 426355000045 Synaptic Flat tetramer interface [polypeptide binding]; other site 426355000046 Synaptic Site I dimer interface [polypeptide binding]; other site 426355000047 DNA binding site [nucleotide binding] 426355000048 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 426355000049 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426355000050 P-loop; other site 426355000051 Magnesium ion binding site [ion binding]; other site 426355000052 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 426355000053 SIR2-like domain; Region: SIR2_2; pfam13289 426355000054 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426355000055 Immunoglobulin domain; Region: Ig; cl11960 426355000056 multiple promoter invertase; Provisional; Region: mpi; PRK13413 426355000057 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 426355000058 catalytic residues [active] 426355000059 catalytic nucleophile [active] 426355000060 Presynaptic Site I dimer interface [polypeptide binding]; other site 426355000061 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 426355000062 Synaptic Flat tetramer interface [polypeptide binding]; other site 426355000063 Synaptic Site I dimer interface [polypeptide binding]; other site 426355000064 DNA binding site [nucleotide binding] 426355000065 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 426355000066 DNA-binding interface [nucleotide binding]; DNA binding site 426355000067 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 426355000068 DnaA N-terminal domain; Region: DnaA_N; pfam11638 426355000069 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 426355000070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355000071 Walker A motif; other site 426355000072 ATP binding site [chemical binding]; other site 426355000073 Walker B motif; other site 426355000074 arginine finger; other site 426355000075 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 426355000076 DnaA box-binding interface [nucleotide binding]; other site 426355000077 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 426355000078 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 426355000079 dimer interface [polypeptide binding]; other site 426355000080 active site 426355000081 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355000082 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 426355000083 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426355000084 substrate binding site [chemical binding]; other site 426355000085 oxyanion hole (OAH) forming residues; other site 426355000086 trimer interface [polypeptide binding]; other site 426355000087 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 426355000088 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 426355000089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355000090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355000091 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426355000092 dimerization interface [polypeptide binding]; other site 426355000093 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 426355000094 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355000095 substrate binding pocket [chemical binding]; other site 426355000096 membrane-bound complex binding site; other site 426355000097 hinge residues; other site 426355000098 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426355000099 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 426355000100 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426355000101 catalytic residue [active] 426355000102 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 426355000103 active site 426355000104 catalytic site [active] 426355000105 substrate binding site [chemical binding]; other site 426355000106 Ligase N family; Region: LIGANc; smart00532 426355000107 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 426355000108 nucleotide binding pocket [chemical binding]; other site 426355000109 K-X-D-G motif; other site 426355000110 catalytic site [active] 426355000111 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 426355000112 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 426355000113 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 426355000114 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 426355000115 Dimer interface [polypeptide binding]; other site 426355000116 BRCT sequence motif; other site 426355000117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355000118 putative substrate translocation pore; other site 426355000119 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 426355000120 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426355000121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355000122 S-adenosylmethionine binding site [chemical binding]; other site 426355000123 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 426355000124 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 426355000125 active site 426355000126 substrate binding site [chemical binding]; other site 426355000127 cosubstrate binding site; other site 426355000128 catalytic site [active] 426355000129 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 426355000130 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 426355000131 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 426355000132 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 426355000133 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 426355000134 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 426355000135 Cation efflux family; Region: Cation_efflux; pfam01545 426355000136 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 426355000137 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426355000138 active site 426355000139 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 426355000140 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 426355000141 active site 426355000142 dimer interface [polypeptide binding]; other site 426355000143 non-prolyl cis peptide bond; other site 426355000144 insertion regions; other site 426355000145 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 426355000146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 426355000147 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 426355000148 Subunit III/VIIa interface [polypeptide binding]; other site 426355000149 Phospholipid binding site [chemical binding]; other site 426355000150 Subunit I/III interface [polypeptide binding]; other site 426355000151 Subunit III/VIb interface [polypeptide binding]; other site 426355000152 Subunit III/VIa interface; other site 426355000153 Subunit III/Vb interface [polypeptide binding]; other site 426355000154 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 426355000155 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 426355000156 UbiA prenyltransferase family; Region: UbiA; pfam01040 426355000157 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 426355000158 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 426355000159 Subunit I/III interface [polypeptide binding]; other site 426355000160 D-pathway; other site 426355000161 Subunit I/VIIc interface [polypeptide binding]; other site 426355000162 Subunit I/IV interface [polypeptide binding]; other site 426355000163 Subunit I/II interface [polypeptide binding]; other site 426355000164 Low-spin heme (heme a) binding site [chemical binding]; other site 426355000165 Subunit I/VIIa interface [polypeptide binding]; other site 426355000166 Dimer interface; other site 426355000167 Subunit I/VIa interface [polypeptide binding]; other site 426355000168 Putative water exit pathway; other site 426355000169 Binuclear center (heme a3/CuB) [ion binding]; other site 426355000170 K-pathway; other site 426355000171 Subunit I/Vb interface [polypeptide binding]; other site 426355000172 Putative proton exit pathway; other site 426355000173 Subunit I/VIb interface; other site 426355000174 Subunit I/VIc interface [polypeptide binding]; other site 426355000175 Electron transfer pathway; other site 426355000176 Subunit I/VIIIb interface [polypeptide binding]; other site 426355000177 Subunit I/VIIb interface [polypeptide binding]; other site 426355000178 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 426355000179 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 426355000180 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 426355000181 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 426355000182 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 426355000183 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 426355000184 active site 426355000185 dimer interface [polypeptide binding]; other site 426355000186 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 426355000187 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 426355000188 active site 426355000189 FMN binding site [chemical binding]; other site 426355000190 substrate binding site [chemical binding]; other site 426355000191 3Fe-4S cluster binding site [ion binding]; other site 426355000192 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 426355000193 domain interface; other site 426355000194 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 426355000195 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426355000196 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 426355000197 active site 426355000198 catalytic triad [active] 426355000199 oxyanion hole [active] 426355000200 Transglycosylase SLT domain; Region: SLT_2; pfam13406 426355000201 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426355000202 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426355000203 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426355000204 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 426355000205 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 426355000206 NAD binding site [chemical binding]; other site 426355000207 homodimer interface [polypeptide binding]; other site 426355000208 active site 426355000209 substrate binding site [chemical binding]; other site 426355000210 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 426355000211 active site 426355000212 tetramer interface; other site 426355000213 N-formylglutamate amidohydrolase; Region: FGase; cl01522 426355000214 Response regulator receiver domain; Region: Response_reg; pfam00072 426355000215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355000216 active site 426355000217 phosphorylation site [posttranslational modification] 426355000218 intermolecular recognition site; other site 426355000219 dimerization interface [polypeptide binding]; other site 426355000220 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 426355000221 GSH binding site [chemical binding]; other site 426355000222 catalytic residues [active] 426355000223 nitrilase; Region: PLN02798 426355000224 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 426355000225 putative active site [active] 426355000226 catalytic triad [active] 426355000227 dimer interface [polypeptide binding]; other site 426355000228 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 426355000229 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 426355000230 Predicted membrane protein [Function unknown]; Region: COG1238 426355000231 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 426355000232 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426355000233 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 426355000234 putative active site [active] 426355000235 Zn binding site [ion binding]; other site 426355000236 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 426355000237 active site 426355000238 intersubunit interface [polypeptide binding]; other site 426355000239 catalytic residue [active] 426355000240 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 426355000241 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426355000242 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426355000243 Walker A/P-loop; other site 426355000244 ATP binding site [chemical binding]; other site 426355000245 Q-loop/lid; other site 426355000246 ABC transporter signature motif; other site 426355000247 Walker B; other site 426355000248 D-loop; other site 426355000249 H-loop/switch region; other site 426355000250 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426355000251 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426355000252 Walker A/P-loop; other site 426355000253 ATP binding site [chemical binding]; other site 426355000254 Q-loop/lid; other site 426355000255 ABC transporter signature motif; other site 426355000256 Walker B; other site 426355000257 D-loop; other site 426355000258 H-loop/switch region; other site 426355000259 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355000260 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426355000261 putative ligand binding site [chemical binding]; other site 426355000262 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426355000263 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426355000264 TM-ABC transporter signature motif; other site 426355000265 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426355000266 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426355000267 TM-ABC transporter signature motif; other site 426355000268 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 426355000269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355000270 ATP binding site [chemical binding]; other site 426355000271 Mg2+ binding site [ion binding]; other site 426355000272 G-X-G motif; other site 426355000273 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 426355000274 ATP binding site [chemical binding]; other site 426355000275 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 426355000276 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426355000277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355000278 NAD(P) binding site [chemical binding]; other site 426355000279 active site 426355000280 acyl-CoA synthetase; Validated; Region: PRK08162 426355000281 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 426355000282 acyl-activating enzyme (AAE) consensus motif; other site 426355000283 putative active site [active] 426355000284 AMP binding site [chemical binding]; other site 426355000285 putative CoA binding site [chemical binding]; other site 426355000286 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426355000287 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426355000288 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426355000289 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355000290 non-specific DNA binding site [nucleotide binding]; other site 426355000291 salt bridge; other site 426355000292 sequence-specific DNA binding site [nucleotide binding]; other site 426355000293 Cupin domain; Region: Cupin_2; cl17218 426355000294 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 426355000295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355000296 S-adenosylmethionine binding site [chemical binding]; other site 426355000297 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 426355000298 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426355000299 RNA binding surface [nucleotide binding]; other site 426355000300 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 426355000301 active site 426355000302 CsbD-like; Region: CsbD; pfam05532 426355000303 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 426355000304 nucleoside/Zn binding site; other site 426355000305 dimer interface [polypeptide binding]; other site 426355000306 catalytic motif [active] 426355000307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355000308 short chain dehydrogenase; Provisional; Region: PRK07326 426355000309 NAD(P) binding site [chemical binding]; other site 426355000310 active site 426355000311 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 426355000312 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355000313 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 426355000314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355000315 putative substrate translocation pore; other site 426355000316 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 426355000317 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 426355000318 Transcriptional regulators [Transcription]; Region: MarR; COG1846 426355000319 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 426355000320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355000321 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426355000322 putative substrate translocation pore; other site 426355000323 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 426355000324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355000325 putative substrate translocation pore; other site 426355000326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355000327 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426355000328 putative substrate translocation pore; other site 426355000329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355000330 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 426355000331 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 426355000332 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 426355000333 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 426355000334 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 426355000335 active site 426355000336 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 426355000337 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 426355000338 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 426355000339 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 426355000340 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 426355000341 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 426355000342 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 426355000343 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426355000344 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 426355000345 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 426355000346 FOG: WD40 repeat [General function prediction only]; Region: COG2319 426355000347 structural tetrad; other site 426355000348 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 426355000349 Response regulator receiver domain; Region: Response_reg; pfam00072 426355000350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355000351 active site 426355000352 phosphorylation site [posttranslational modification] 426355000353 intermolecular recognition site; other site 426355000354 dimerization interface [polypeptide binding]; other site 426355000355 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 426355000356 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 426355000357 putative active site [active] 426355000358 Ap4A binding site [chemical binding]; other site 426355000359 nudix motif; other site 426355000360 putative metal binding site [ion binding]; other site 426355000361 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 426355000362 putative active site [active] 426355000363 NodB motif; other site 426355000364 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 426355000365 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 426355000366 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 426355000367 protein binding site [polypeptide binding]; other site 426355000368 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 426355000369 Catalytic dyad [active] 426355000370 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 426355000371 Peptidase family M23; Region: Peptidase_M23; pfam01551 426355000372 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 426355000373 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 426355000374 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 426355000375 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 426355000376 active site 426355000377 (T/H)XGH motif; other site 426355000378 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 426355000379 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 426355000380 putative catalytic cysteine [active] 426355000381 gamma-glutamyl kinase; Provisional; Region: PRK05429 426355000382 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 426355000383 nucleotide binding site [chemical binding]; other site 426355000384 homotetrameric interface [polypeptide binding]; other site 426355000385 putative phosphate binding site [ion binding]; other site 426355000386 putative allosteric binding site; other site 426355000387 PUA domain; Region: PUA; pfam01472 426355000388 GTPase CgtA; Reviewed; Region: obgE; PRK12299 426355000389 GTP1/OBG; Region: GTP1_OBG; pfam01018 426355000390 Obg GTPase; Region: Obg; cd01898 426355000391 G1 box; other site 426355000392 GTP/Mg2+ binding site [chemical binding]; other site 426355000393 Switch I region; other site 426355000394 G2 box; other site 426355000395 G3 box; other site 426355000396 Switch II region; other site 426355000397 G4 box; other site 426355000398 G5 box; other site 426355000399 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 426355000400 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 426355000401 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 426355000402 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 426355000403 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 426355000404 YceI-like domain; Region: YceI; smart00867 426355000405 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 426355000406 RuvA N terminal domain; Region: RuvA_N; pfam01330 426355000407 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 426355000408 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 426355000409 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 426355000410 heme binding site [chemical binding]; other site 426355000411 ferroxidase pore; other site 426355000412 ferroxidase diiron center [ion binding]; other site 426355000413 dihydrodipicolinate reductase; Provisional; Region: PRK00048 426355000414 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 426355000415 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 426355000416 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426355000417 catalytic core [active] 426355000418 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 426355000419 Protein of unknown function (DUF817); Region: DUF817; pfam05675 426355000420 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 426355000421 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 426355000422 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 426355000423 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 426355000424 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 426355000425 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 426355000426 hypothetical protein; Provisional; Region: PRK13694 426355000427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 426355000428 N-formylglutamate amidohydrolase; Region: FGase; cl01522 426355000429 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 426355000430 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 426355000431 MOFRL family; Region: MOFRL; pfam05161 426355000432 Protein of unknown function (DUF1036); Region: DUF1036; pfam06282 426355000433 pyruvate kinase; Provisional; Region: PRK06247 426355000434 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 426355000435 domain interfaces; other site 426355000436 active site 426355000437 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426355000438 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426355000439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 426355000440 binding surface 426355000441 TPR motif; other site 426355000442 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 426355000443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355000444 PAS fold; Region: PAS_3; pfam08447 426355000445 putative active site [active] 426355000446 heme pocket [chemical binding]; other site 426355000447 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 426355000448 substrate binding site [chemical binding]; other site 426355000449 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 426355000450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355000451 S-adenosylmethionine binding site [chemical binding]; other site 426355000452 aspartate kinase; Reviewed; Region: PRK06635 426355000453 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 426355000454 putative nucleotide binding site [chemical binding]; other site 426355000455 putative catalytic residues [active] 426355000456 putative Mg ion binding site [ion binding]; other site 426355000457 putative aspartate binding site [chemical binding]; other site 426355000458 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 426355000459 putative allosteric regulatory site; other site 426355000460 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 426355000461 GAF domain; Region: GAF; pfam01590 426355000462 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 426355000463 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 426355000464 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 426355000465 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 426355000466 peptide chain release factor 1; Validated; Region: prfA; PRK00591 426355000467 This domain is found in peptide chain release factors; Region: PCRF; smart00937 426355000468 RF-1 domain; Region: RF-1; pfam00472 426355000469 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 426355000470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355000471 S-adenosylmethionine binding site [chemical binding]; other site 426355000472 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 426355000473 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 426355000474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355000475 S-adenosylmethionine binding site [chemical binding]; other site 426355000476 exopolyphosphatase; Region: exo_poly_only; TIGR03706 426355000477 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 426355000478 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 426355000479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355000480 active site 426355000481 phosphorylation site [posttranslational modification] 426355000482 intermolecular recognition site; other site 426355000483 dimerization interface [polypeptide binding]; other site 426355000484 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 426355000485 DNA-binding site [nucleotide binding]; DNA binding site 426355000486 RNA-binding motif; other site 426355000487 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 426355000488 DNA-binding site [nucleotide binding]; DNA binding site 426355000489 RNA-binding motif; other site 426355000490 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 426355000491 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 426355000492 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 426355000493 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 426355000494 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 426355000495 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426355000496 NAD(P) binding site [chemical binding]; other site 426355000497 catalytic residues [active] 426355000498 Protein of unknown function (DUF779); Region: DUF779; cl01432 426355000499 Uncharacterized conserved protein [Function unknown]; Region: COG2128 426355000500 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 426355000501 Cupin domain; Region: Cupin_2; cl17218 426355000502 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 426355000503 Sel1-like repeats; Region: SEL1; smart00671 426355000504 Sel1-like repeats; Region: SEL1; smart00671 426355000505 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 426355000506 active site 426355000507 thiamine phosphate binding site [chemical binding]; other site 426355000508 pyrophosphate binding site [ion binding]; other site 426355000509 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 426355000510 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 426355000511 intersubunit interface [polypeptide binding]; other site 426355000512 active site 426355000513 zinc binding site [ion binding]; other site 426355000514 Na+ binding site [ion binding]; other site 426355000515 Phosphoglycerate kinase; Region: PGK; pfam00162 426355000516 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 426355000517 substrate binding site [chemical binding]; other site 426355000518 hinge regions; other site 426355000519 ADP binding site [chemical binding]; other site 426355000520 catalytic site [active] 426355000521 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 426355000522 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 426355000523 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 426355000524 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 426355000525 Cell division protein ZapA; Region: ZapA; pfam05164 426355000526 Predicted transcriptional regulators [Transcription]; Region: COG1733 426355000527 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 426355000528 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 426355000529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355000530 NAD(P) binding site [chemical binding]; other site 426355000531 active site 426355000532 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426355000533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355000534 DNA-binding site [nucleotide binding]; DNA binding site 426355000535 FCD domain; Region: FCD; pfam07729 426355000536 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 426355000537 Coenzyme A transferase; Region: CoA_trans; cl17247 426355000538 malonate decarboxylase subunit delta; Provisional; Region: PRK02103 426355000539 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 426355000540 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 426355000541 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 426355000542 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 426355000543 Acyl transferase domain; Region: Acyl_transf_1; cl08282 426355000544 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 426355000545 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 426355000546 NADP-binding site; other site 426355000547 homotetramer interface [polypeptide binding]; other site 426355000548 substrate binding site [chemical binding]; other site 426355000549 homodimer interface [polypeptide binding]; other site 426355000550 active site 426355000551 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426355000552 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 426355000553 NAD(P) binding site [chemical binding]; other site 426355000554 catalytic residues [active] 426355000555 colanic acid exporter; Provisional; Region: PRK10459 426355000556 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 426355000557 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355000558 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 426355000559 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 426355000560 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355000561 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 426355000562 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355000563 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 426355000564 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355000565 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 426355000566 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426355000567 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355000568 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 426355000569 putative ADP-binding pocket [chemical binding]; other site 426355000570 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 426355000571 acyl carrier protein; Provisional; Region: PRK07081 426355000572 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426355000573 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426355000574 active site 426355000575 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 426355000576 dimer interface [polypeptide binding]; other site 426355000577 motif 1; other site 426355000578 active site 426355000579 motif 2; other site 426355000580 motif 3; other site 426355000581 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 426355000582 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 426355000583 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 426355000584 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 426355000585 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 426355000586 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 426355000587 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 426355000588 substrate binding pocket [chemical binding]; other site 426355000589 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 426355000590 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 426355000591 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 426355000592 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355000593 Ligand Binding Site [chemical binding]; other site 426355000594 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 426355000595 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426355000596 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 426355000597 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355000598 putative CheW interface [polypeptide binding]; other site 426355000599 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355000600 HWE histidine kinase; Region: HWE_HK; cl06527 426355000601 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355000602 PAS domain; Region: PAS_9; pfam13426 426355000603 putative active site [active] 426355000604 heme pocket [chemical binding]; other site 426355000605 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355000606 PAS domain; Region: PAS_9; pfam13426 426355000607 putative active site [active] 426355000608 heme pocket [chemical binding]; other site 426355000609 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355000610 dimer interface [polypeptide binding]; other site 426355000611 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 426355000612 putative CheW interface [polypeptide binding]; other site 426355000613 urate oxidase; Region: urate_oxi; TIGR03383 426355000614 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 426355000615 active site 426355000616 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 426355000617 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 426355000618 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355000619 catalytic loop [active] 426355000620 iron binding site [ion binding]; other site 426355000621 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426355000622 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426355000623 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426355000624 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355000625 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 426355000626 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 426355000627 active site 426355000628 phosphorylation site [posttranslational modification] 426355000629 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355000630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355000631 active site 426355000632 phosphorylation site [posttranslational modification] 426355000633 intermolecular recognition site; other site 426355000634 dimerization interface [polypeptide binding]; other site 426355000635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355000636 DNA binding site [nucleotide binding] 426355000637 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 426355000638 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 426355000639 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 426355000640 Ligand Binding Site [chemical binding]; other site 426355000641 GAF domain; Region: GAF_3; pfam13492 426355000642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355000643 dimer interface [polypeptide binding]; other site 426355000644 phosphorylation site [posttranslational modification] 426355000645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355000646 ATP binding site [chemical binding]; other site 426355000647 Mg2+ binding site [ion binding]; other site 426355000648 G-X-G motif; other site 426355000649 potassium-transporting ATPase subunit C; Provisional; Region: PRK13999 426355000650 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 426355000651 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 426355000652 Soluble P-type ATPase [General function prediction only]; Region: COG4087 426355000653 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 426355000654 PAS fold; Region: PAS_7; pfam12860 426355000655 PAS fold; Region: PAS_3; pfam08447 426355000656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355000657 putative active site [active] 426355000658 heme pocket [chemical binding]; other site 426355000659 GAF domain; Region: GAF_2; pfam13185 426355000660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355000661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355000662 dimer interface [polypeptide binding]; other site 426355000663 phosphorylation site [posttranslational modification] 426355000664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355000665 ATP binding site [chemical binding]; other site 426355000666 Mg2+ binding site [ion binding]; other site 426355000667 G-X-G motif; other site 426355000668 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355000669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355000670 active site 426355000671 phosphorylation site [posttranslational modification] 426355000672 intermolecular recognition site; other site 426355000673 dimerization interface [polypeptide binding]; other site 426355000674 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355000675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355000676 active site 426355000677 phosphorylation site [posttranslational modification] 426355000678 intermolecular recognition site; other site 426355000679 dimerization interface [polypeptide binding]; other site 426355000680 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355000681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355000682 active site 426355000683 phosphorylation site [posttranslational modification] 426355000684 intermolecular recognition site; other site 426355000685 dimerization interface [polypeptide binding]; other site 426355000686 Response regulator receiver domain; Region: Response_reg; pfam00072 426355000687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355000688 active site 426355000689 phosphorylation site [posttranslational modification] 426355000690 intermolecular recognition site; other site 426355000691 dimerization interface [polypeptide binding]; other site 426355000692 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 426355000693 cyclase homology domain; Region: CHD; cd07302 426355000694 nucleotidyl binding site; other site 426355000695 metal binding site [ion binding]; metal-binding site 426355000696 dimer interface [polypeptide binding]; other site 426355000697 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 426355000698 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355000699 dimerization interface [polypeptide binding]; other site 426355000700 PAS fold; Region: PAS_7; pfam12860 426355000701 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355000702 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355000703 metal binding site [ion binding]; metal-binding site 426355000704 active site 426355000705 I-site; other site 426355000706 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355000707 PBP superfamily domain; Region: PBP_like_2; cl17296 426355000708 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 426355000709 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355000710 catalytic loop [active] 426355000711 iron binding site [ion binding]; other site 426355000712 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 426355000713 FAD binding pocket [chemical binding]; other site 426355000714 FAD binding motif [chemical binding]; other site 426355000715 phosphate binding motif [ion binding]; other site 426355000716 beta-alpha-beta structure motif; other site 426355000717 NAD binding pocket [chemical binding]; other site 426355000718 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 426355000719 DOMON-like domain of an uncharacterized protein family; Region: DOMON_like_cytochrome; cd09625 426355000720 putative ligand binding site [chemical binding]; other site 426355000721 Porin subfamily; Region: Porin_2; pfam02530 426355000722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355000723 HAMP domain; Region: HAMP; pfam00672 426355000724 dimerization interface [polypeptide binding]; other site 426355000725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355000726 dimer interface [polypeptide binding]; other site 426355000727 phosphorylation site [posttranslational modification] 426355000728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355000729 ATP binding site [chemical binding]; other site 426355000730 Mg2+ binding site [ion binding]; other site 426355000731 G-X-G motif; other site 426355000732 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355000733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355000734 active site 426355000735 phosphorylation site [posttranslational modification] 426355000736 intermolecular recognition site; other site 426355000737 dimerization interface [polypeptide binding]; other site 426355000738 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355000739 DNA binding site [nucleotide binding] 426355000740 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426355000741 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355000742 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355000743 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 426355000744 PilZ domain; Region: PilZ; pfam07238 426355000745 amidase; Provisional; Region: PRK07486 426355000746 Amidase; Region: Amidase; pfam01425 426355000747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355000748 D-galactonate transporter; Region: 2A0114; TIGR00893 426355000749 putative substrate translocation pore; other site 426355000750 D-serine dehydratase; Provisional; Region: PRK02991 426355000751 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426355000752 catalytic residue [active] 426355000753 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 426355000754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355000755 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 426355000756 dimerization interface [polypeptide binding]; other site 426355000757 substrate binding pocket [chemical binding]; other site 426355000758 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355000759 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355000760 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426355000761 dimerization interface [polypeptide binding]; other site 426355000762 NmrA-like family; Region: NmrA; pfam05368 426355000763 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 426355000764 NADP binding site [chemical binding]; other site 426355000765 active site 426355000766 regulatory binding site [polypeptide binding]; other site 426355000767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 426355000768 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 426355000769 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355000770 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426355000771 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 426355000772 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 426355000773 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426355000774 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 426355000775 active site 426355000776 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 426355000777 dimer interface [polypeptide binding]; other site 426355000778 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426355000779 ligand binding site [chemical binding]; other site 426355000780 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 426355000781 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355000782 DNA-binding site [nucleotide binding]; DNA binding site 426355000783 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426355000784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355000785 homodimer interface [polypeptide binding]; other site 426355000786 catalytic residue [active] 426355000787 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 426355000788 Predicted amidohydrolase [General function prediction only]; Region: COG0388 426355000789 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 426355000790 putative active site [active] 426355000791 catalytic triad [active] 426355000792 putative dimer interface [polypeptide binding]; other site 426355000793 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 426355000794 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355000795 FeS/SAM binding site; other site 426355000796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426355000797 Coenzyme A binding pocket [chemical binding]; other site 426355000798 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 426355000799 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 426355000800 dimerization interface [polypeptide binding]; other site 426355000801 putative ATP binding site [chemical binding]; other site 426355000802 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 426355000803 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 426355000804 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 426355000805 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426355000806 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 426355000807 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426355000808 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 426355000809 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355000810 dimer interface [polypeptide binding]; other site 426355000811 putative CheW interface [polypeptide binding]; other site 426355000812 glutamyl-tRNA synthetase, bacterial family; Region: gltX_bact; TIGR00464 426355000813 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 426355000814 Predicted membrane protein [Function unknown]; Region: COG4244 426355000815 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 426355000816 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 426355000817 HD domain; Region: HD_4; pfam13328 426355000818 PRC-barrel domain; Region: PRC; pfam05239 426355000819 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 426355000820 putative FMN binding site [chemical binding]; other site 426355000821 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 426355000822 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426355000823 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426355000824 catalytic residue [active] 426355000825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 426355000826 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 426355000827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426355000828 TPR motif; other site 426355000829 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 426355000830 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 426355000831 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 426355000832 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 426355000833 DXD motif; other site 426355000834 Response regulator receiver domain; Region: Response_reg; pfam00072 426355000835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355000836 active site 426355000837 phosphorylation site [posttranslational modification] 426355000838 intermolecular recognition site; other site 426355000839 dimerization interface [polypeptide binding]; other site 426355000840 CsbD-like; Region: CsbD; pfam05532 426355000841 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 426355000842 Peptidase family M23; Region: Peptidase_M23; pfam01551 426355000843 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 426355000844 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 426355000845 active site 426355000846 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426355000847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355000848 putative substrate translocation pore; other site 426355000849 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 426355000850 Protein export membrane protein; Region: SecD_SecF; cl14618 426355000851 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 426355000852 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355000853 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355000854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426355000855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355000856 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 426355000857 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426355000858 cyclase homology domain; Region: CHD; cd07302 426355000859 nucleotidyl binding site; other site 426355000860 metal binding site [ion binding]; metal-binding site 426355000861 dimer interface [polypeptide binding]; other site 426355000862 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 426355000863 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 426355000864 Domain of unknown function DUF21; Region: DUF21; pfam01595 426355000865 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 426355000866 Transporter associated domain; Region: CorC_HlyC; smart01091 426355000867 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426355000868 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426355000869 Walker A/P-loop; other site 426355000870 ATP binding site [chemical binding]; other site 426355000871 Q-loop/lid; other site 426355000872 ABC transporter signature motif; other site 426355000873 Walker B; other site 426355000874 D-loop; other site 426355000875 H-loop/switch region; other site 426355000876 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426355000877 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426355000878 TM-ABC transporter signature motif; other site 426355000879 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426355000880 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426355000881 Walker A/P-loop; other site 426355000882 ATP binding site [chemical binding]; other site 426355000883 Q-loop/lid; other site 426355000884 ABC transporter signature motif; other site 426355000885 Walker B; other site 426355000886 D-loop; other site 426355000887 H-loop/switch region; other site 426355000888 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426355000889 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426355000890 TM-ABC transporter signature motif; other site 426355000891 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355000892 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 426355000893 putative ligand binding site [chemical binding]; other site 426355000894 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 426355000895 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 426355000896 hexamer interface [polypeptide binding]; other site 426355000897 active site 2 [active] 426355000898 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355000899 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355000900 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426355000901 dimerization interface [polypeptide binding]; other site 426355000902 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 426355000903 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 426355000904 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 426355000905 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 426355000906 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 426355000907 active site 426355000908 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 426355000909 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 426355000910 TSCPD domain; Region: TSCPD; pfam12637 426355000911 NADH dehydrogenase; Validated; Region: PRK08183 426355000912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 426355000913 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 426355000914 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 426355000915 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 426355000916 putative active site [active] 426355000917 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 426355000918 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 426355000919 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 426355000920 Chain length determinant protein; Region: Wzz; pfam02706 426355000921 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 426355000922 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 426355000923 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 426355000924 SLBB domain; Region: SLBB; pfam10531 426355000925 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 426355000926 Transglycosylase; Region: Transgly; pfam00912 426355000927 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 426355000928 trehalose synthase; Region: treS_nterm; TIGR02456 426355000929 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 426355000930 active site 426355000931 catalytic site [active] 426355000932 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 426355000933 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426355000934 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426355000935 active site 426355000936 catalytic tetrad [active] 426355000937 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 426355000938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355000939 Mg2+ binding site [ion binding]; other site 426355000940 G-X-G motif; other site 426355000941 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 426355000942 anchoring element; other site 426355000943 dimer interface [polypeptide binding]; other site 426355000944 ATP binding site [chemical binding]; other site 426355000945 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 426355000946 active site 426355000947 putative metal-binding site [ion binding]; other site 426355000948 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 426355000949 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426355000950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355000951 active site 426355000952 phosphorylation site [posttranslational modification] 426355000953 intermolecular recognition site; other site 426355000954 dimerization interface [polypeptide binding]; other site 426355000955 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355000956 DNA binding residues [nucleotide binding] 426355000957 dimerization interface [polypeptide binding]; other site 426355000958 HAMP domain; Region: HAMP; pfam00672 426355000959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 426355000960 Histidine kinase; Region: HisKA_3; pfam07730 426355000961 Cupin domain; Region: Cupin_2; cl17218 426355000962 choline dehydrogenase; Validated; Region: PRK02106 426355000963 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 426355000964 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355000965 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355000966 ligand binding site [chemical binding]; other site 426355000967 flexible hinge region; other site 426355000968 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426355000969 putative switch regulator; other site 426355000970 non-specific DNA interactions [nucleotide binding]; other site 426355000971 DNA binding site [nucleotide binding] 426355000972 sequence specific DNA binding site [nucleotide binding]; other site 426355000973 putative cAMP binding site [chemical binding]; other site 426355000974 FecR protein; Region: FecR; pfam04773 426355000975 CHASE2 domain; Region: CHASE2; pfam05226 426355000976 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426355000977 cyclase homology domain; Region: CHD; cd07302 426355000978 nucleotidyl binding site; other site 426355000979 metal binding site [ion binding]; metal-binding site 426355000980 dimer interface [polypeptide binding]; other site 426355000981 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355000982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355000983 active site 426355000984 phosphorylation site [posttranslational modification] 426355000985 intermolecular recognition site; other site 426355000986 dimerization interface [polypeptide binding]; other site 426355000987 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355000988 DNA binding site [nucleotide binding] 426355000989 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355000990 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426355000991 putative ligand binding site [chemical binding]; other site 426355000992 YciI-like protein; Reviewed; Region: PRK12863 426355000993 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 426355000994 choline dehydrogenase; Validated; Region: PRK02106 426355000995 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426355000996 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 426355000997 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 426355000998 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 426355000999 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 426355001000 shikimate binding site; other site 426355001001 NAD(P) binding site [chemical binding]; other site 426355001002 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426355001003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355001004 NAD(P) binding site [chemical binding]; other site 426355001005 active site 426355001006 acetolactate synthase catalytic subunit; Validated; Region: PRK06112 426355001007 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426355001008 PYR/PP interface [polypeptide binding]; other site 426355001009 dimer interface [polypeptide binding]; other site 426355001010 TPP binding site [chemical binding]; other site 426355001011 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426355001012 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 426355001013 TPP-binding site [chemical binding]; other site 426355001014 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 426355001015 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 426355001016 NAD(P) binding site [chemical binding]; other site 426355001017 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 426355001018 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 426355001019 NAD(P) binding site [chemical binding]; other site 426355001020 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426355001021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355001022 DNA-binding site [nucleotide binding]; DNA binding site 426355001023 FCD domain; Region: FCD; pfam07729 426355001024 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 426355001025 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355001026 dimerization interface [polypeptide binding]; other site 426355001027 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355001028 dimer interface [polypeptide binding]; other site 426355001029 putative CheW interface [polypeptide binding]; other site 426355001030 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 426355001031 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426355001032 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426355001033 catalytic residue [active] 426355001034 Protein of unknown function (DUF962); Region: DUF962; cl01879 426355001035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355001036 S-adenosylmethionine binding site [chemical binding]; other site 426355001037 Transglycosylase SLT domain; Region: SLT_2; pfam13406 426355001038 murein hydrolase B; Provisional; Region: PRK10760; cl17906 426355001039 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 426355001040 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 426355001041 malate:quinone oxidoreductase; Validated; Region: PRK05257 426355001042 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 426355001043 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 426355001044 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 426355001045 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 426355001046 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426355001047 Methyltransferase domain; Region: Methyltransf_11; pfam08241 426355001048 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 426355001049 Coenzyme A transferase; Region: CoA_trans; smart00882 426355001050 Coenzyme A transferase; Region: CoA_trans; cl17247 426355001051 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 426355001052 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 426355001053 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 426355001054 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 426355001055 Walker A/P-loop; other site 426355001056 ATP binding site [chemical binding]; other site 426355001057 Q-loop/lid; other site 426355001058 ABC transporter signature motif; other site 426355001059 Walker B; other site 426355001060 D-loop; other site 426355001061 H-loop/switch region; other site 426355001062 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426355001063 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 426355001064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355001065 dimer interface [polypeptide binding]; other site 426355001066 conserved gate region; other site 426355001067 putative PBP binding loops; other site 426355001068 ABC-ATPase subunit interface; other site 426355001069 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426355001070 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355001071 substrate binding pocket [chemical binding]; other site 426355001072 membrane-bound complex binding site; other site 426355001073 hinge residues; other site 426355001074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355001075 sequence-specific DNA binding site [nucleotide binding]; other site 426355001076 salt bridge; other site 426355001077 Cupin domain; Region: Cupin_2; pfam07883 426355001078 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 426355001079 TadE-like protein; Region: TadE; pfam07811 426355001080 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 426355001081 TadE-like protein; Region: TadE; pfam07811 426355001082 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 426355001083 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426355001084 Zn2+ binding site [ion binding]; other site 426355001085 Mg2+ binding site [ion binding]; other site 426355001086 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 426355001087 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 426355001088 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 426355001089 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355001090 dimer interface [polypeptide binding]; other site 426355001091 phosphorylation site [posttranslational modification] 426355001092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355001093 ATP binding site [chemical binding]; other site 426355001094 Mg2+ binding site [ion binding]; other site 426355001095 G-X-G motif; other site 426355001096 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 426355001097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355001098 active site 426355001099 phosphorylation site [posttranslational modification] 426355001100 intermolecular recognition site; other site 426355001101 dimerization interface [polypeptide binding]; other site 426355001102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355001103 Walker A motif; other site 426355001104 ATP binding site [chemical binding]; other site 426355001105 Walker B motif; other site 426355001106 arginine finger; other site 426355001107 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 426355001108 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355001109 HWE histidine kinase; Region: HWE_HK; cl06527 426355001110 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 426355001111 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355001112 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 426355001113 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 426355001114 DXD motif; other site 426355001115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 426355001116 Transposase; Region: HTH_Tnp_1; cl17663 426355001117 putative transposase OrfB; Reviewed; Region: PHA02517 426355001118 HTH-like domain; Region: HTH_21; pfam13276 426355001119 Integrase core domain; Region: rve; pfam00665 426355001120 Integrase core domain; Region: rve_2; pfam13333 426355001121 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355001122 PAS domain; Region: PAS_9; pfam13426 426355001123 putative active site [active] 426355001124 heme pocket [chemical binding]; other site 426355001125 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426355001126 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355001127 dimer interface [polypeptide binding]; other site 426355001128 putative CheW interface [polypeptide binding]; other site 426355001129 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355001130 dimer interface [polypeptide binding]; other site 426355001131 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 426355001132 putative CheW interface [polypeptide binding]; other site 426355001133 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355001134 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355001135 metal binding site [ion binding]; metal-binding site 426355001136 active site 426355001137 I-site; other site 426355001138 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355001139 PAS fold; Region: PAS_3; pfam08447 426355001140 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355001141 putative active site [active] 426355001142 heme pocket [chemical binding]; other site 426355001143 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355001144 PAS fold; Region: PAS_3; pfam08447 426355001145 putative active site [active] 426355001146 heme pocket [chemical binding]; other site 426355001147 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355001148 non-specific DNA binding site [nucleotide binding]; other site 426355001149 salt bridge; other site 426355001150 sequence-specific DNA binding site [nucleotide binding]; other site 426355001151 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 426355001152 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 426355001153 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355001154 Ligand Binding Site [chemical binding]; other site 426355001155 Cytochrome c; Region: Cytochrom_C; cl11414 426355001156 Sensors of blue-light using FAD; Region: BLUF; pfam04940 426355001157 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355001158 Ligand Binding Site [chemical binding]; other site 426355001159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355001160 PAS fold; Region: PAS_3; pfam08447 426355001161 putative active site [active] 426355001162 heme pocket [chemical binding]; other site 426355001163 PAS domain S-box; Region: sensory_box; TIGR00229 426355001164 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355001165 putative active site [active] 426355001166 heme pocket [chemical binding]; other site 426355001167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355001168 dimer interface [polypeptide binding]; other site 426355001169 phosphorylation site [posttranslational modification] 426355001170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355001171 ATP binding site [chemical binding]; other site 426355001172 G-X-G motif; other site 426355001173 response regulator FixJ; Provisional; Region: fixJ; PRK09390 426355001174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355001175 active site 426355001176 phosphorylation site [posttranslational modification] 426355001177 intermolecular recognition site; other site 426355001178 dimerization interface [polypeptide binding]; other site 426355001179 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355001180 DNA binding residues [nucleotide binding] 426355001181 dimerization interface [polypeptide binding]; other site 426355001182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355001183 Response regulator receiver domain; Region: Response_reg; pfam00072 426355001184 active site 426355001185 phosphorylation site [posttranslational modification] 426355001186 intermolecular recognition site; other site 426355001187 dimerization interface [polypeptide binding]; other site 426355001188 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355001189 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355001190 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 426355001191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355001192 Walker A/P-loop; other site 426355001193 ATP binding site [chemical binding]; other site 426355001194 Q-loop/lid; other site 426355001195 ABC transporter signature motif; other site 426355001196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355001197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355001198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426355001199 dimerization interface [polypeptide binding]; other site 426355001200 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355001201 ligand binding site [chemical binding]; other site 426355001202 flexible hinge region; other site 426355001203 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426355001204 putative switch regulator; other site 426355001205 non-specific DNA interactions [nucleotide binding]; other site 426355001206 DNA binding site [nucleotide binding] 426355001207 sequence specific DNA binding site [nucleotide binding]; other site 426355001208 putative cAMP binding site [chemical binding]; other site 426355001209 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355001210 Ligand Binding Site [chemical binding]; other site 426355001211 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 426355001212 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 426355001213 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 426355001214 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 426355001215 Soluble P-type ATPase [General function prediction only]; Region: COG4087 426355001216 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 426355001217 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 426355001218 C-terminal peptidase (prc); Region: prc; TIGR00225 426355001219 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 426355001220 protein binding site [polypeptide binding]; other site 426355001221 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 426355001222 Catalytic dyad [active] 426355001223 magnesium-transporting ATPase; Provisional; Region: PRK15122 426355001224 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 426355001225 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 426355001226 Soluble P-type ATPase [General function prediction only]; Region: COG4087 426355001227 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 426355001228 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 426355001229 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 426355001230 BON domain; Region: BON; pfam04972 426355001231 BON domain; Region: BON; pfam04972 426355001232 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 426355001233 propionate/acetate kinase; Provisional; Region: PRK12379 426355001234 putative phosphoketolase; Provisional; Region: PRK05261 426355001235 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 426355001236 TPP-binding site; other site 426355001237 XFP C-terminal domain; Region: XFP_C; pfam09363 426355001238 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 426355001239 BON domain; Region: BON; pfam04972 426355001240 BON domain; Region: BON; pfam04972 426355001241 BON domain; Region: BON; pfam04972 426355001242 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 426355001243 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 426355001244 putative NAD(P) binding site [chemical binding]; other site 426355001245 putative substrate binding site [chemical binding]; other site 426355001246 catalytic Zn binding site [ion binding]; other site 426355001247 structural Zn binding site [ion binding]; other site 426355001248 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355001249 Ligand Binding Site [chemical binding]; other site 426355001250 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355001251 Ligand Binding Site [chemical binding]; other site 426355001252 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 426355001253 Cytochrome c; Region: Cytochrom_C; pfam00034 426355001254 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355001255 Ligand Binding Site [chemical binding]; other site 426355001256 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355001257 Ligand Binding Site [chemical binding]; other site 426355001258 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 426355001259 BON domain; Region: BON; pfam04972 426355001260 BON domain; Region: BON; pfam04972 426355001261 BON domain; Region: BON; pfam04972 426355001262 response regulator; Provisional; Region: PRK13435 426355001263 Ion channel; Region: Ion_trans_2; pfam07885 426355001264 SPW repeat; Region: SPW; pfam03779 426355001265 Cytochrome c; Region: Cytochrom_C; pfam00034 426355001266 Universal stress protein family; Region: Usp; pfam00582 426355001267 Ligand Binding Site [chemical binding]; other site 426355001268 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355001269 Ligand Binding Site [chemical binding]; other site 426355001270 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 426355001271 HTH-like domain; Region: HTH_21; pfam13276 426355001272 Integrase core domain; Region: rve; pfam00665 426355001273 Integrase core domain; Region: rve_3; pfam13683 426355001274 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 426355001275 DNA-binding interface [nucleotide binding]; DNA binding site 426355001276 Winged helix-turn helix; Region: HTH_29; pfam13551 426355001277 CHRD domain; Region: CHRD; pfam07452 426355001278 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426355001279 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426355001280 active site 426355001281 catalytic tetrad [active] 426355001282 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 426355001283 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 426355001284 TLC ATP/ADP transporter; Region: TLC; cl03940 426355001285 GMP synthase; Reviewed; Region: guaA; PRK00074 426355001286 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 426355001287 AMP/PPi binding site [chemical binding]; other site 426355001288 candidate oxyanion hole; other site 426355001289 catalytic triad [active] 426355001290 potential glutamine specificity residues [chemical binding]; other site 426355001291 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 426355001292 ATP Binding subdomain [chemical binding]; other site 426355001293 Ligand Binding sites [chemical binding]; other site 426355001294 Dimerization subdomain; other site 426355001295 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 426355001296 active site 426355001297 oxyanion hole [active] 426355001298 catalytic triad [active] 426355001299 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 426355001300 homodimer interaction site [polypeptide binding]; other site 426355001301 cofactor binding site; other site 426355001302 AMP nucleosidase; Provisional; Region: PRK08292 426355001303 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 426355001304 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 426355001305 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 426355001306 transmembrane helices; other site 426355001307 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 426355001308 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 426355001309 Iron-sulfur protein interface; other site 426355001310 proximal quinone binding site [chemical binding]; other site 426355001311 SdhD (CybS) interface [polypeptide binding]; other site 426355001312 proximal heme binding site [chemical binding]; other site 426355001313 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 426355001314 putative SdhC subunit interface [polypeptide binding]; other site 426355001315 putative proximal heme binding site [chemical binding]; other site 426355001316 putative Iron-sulfur protein interface [polypeptide binding]; other site 426355001317 putative proximal quinone binding site; other site 426355001318 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 426355001319 L-aspartate oxidase; Provisional; Region: PRK06175 426355001320 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 426355001321 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 426355001322 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 426355001323 Protease inhibitor Inh; Region: Inh; pfam02974 426355001324 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 426355001325 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426355001326 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 426355001327 Walker A/P-loop; other site 426355001328 ATP binding site [chemical binding]; other site 426355001329 Q-loop/lid; other site 426355001330 ABC transporter signature motif; other site 426355001331 Walker B; other site 426355001332 D-loop; other site 426355001333 H-loop/switch region; other site 426355001334 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 426355001335 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 426355001336 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 426355001337 [2Fe-2S] cluster binding site [ion binding]; other site 426355001338 cytochrome b; Provisional; Region: CYTB; MTH00191 426355001339 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 426355001340 Qi binding site; other site 426355001341 intrachain domain interface; other site 426355001342 interchain domain interface [polypeptide binding]; other site 426355001343 heme bH binding site [chemical binding]; other site 426355001344 heme bL binding site [chemical binding]; other site 426355001345 Qo binding site; other site 426355001346 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 426355001347 interchain domain interface [polypeptide binding]; other site 426355001348 intrachain domain interface; other site 426355001349 Qi binding site; other site 426355001350 Qo binding site; other site 426355001351 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 426355001352 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 426355001353 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 426355001354 putative active site pocket [active] 426355001355 4-fold oligomerization interface [polypeptide binding]; other site 426355001356 metal binding residues [ion binding]; metal-binding site 426355001357 3-fold/trimer interface [polypeptide binding]; other site 426355001358 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 426355001359 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 426355001360 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 426355001361 putative active site [active] 426355001362 oxyanion strand; other site 426355001363 catalytic triad [active] 426355001364 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 426355001365 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 426355001366 catalytic residues [active] 426355001367 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 426355001368 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 426355001369 substrate binding site [chemical binding]; other site 426355001370 glutamase interaction surface [polypeptide binding]; other site 426355001371 dihydroorotase; Validated; Region: PRK09059 426355001372 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 426355001373 active site 426355001374 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 426355001375 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 426355001376 DNA protecting protein DprA; Region: dprA; TIGR00732 426355001377 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 426355001378 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 426355001379 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 426355001380 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 426355001381 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 426355001382 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 426355001383 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 426355001384 GatB domain; Region: GatB_Yqey; smart00845 426355001385 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 426355001386 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355001387 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355001388 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 426355001389 Fusaric acid resistance protein family; Region: FUSC; pfam04632 426355001390 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 426355001391 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 426355001392 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 426355001393 C-terminal domain interface [polypeptide binding]; other site 426355001394 GSH binding site (G-site) [chemical binding]; other site 426355001395 dimer interface [polypeptide binding]; other site 426355001396 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 426355001397 N-terminal domain interface [polypeptide binding]; other site 426355001398 dimer interface [polypeptide binding]; other site 426355001399 substrate binding pocket (H-site) [chemical binding]; other site 426355001400 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 426355001401 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 426355001402 active site 426355001403 multimer interface [polypeptide binding]; other site 426355001404 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 426355001405 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 426355001406 active site 426355001407 substrate binding site [chemical binding]; other site 426355001408 cosubstrate binding site; other site 426355001409 catalytic site [active] 426355001410 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 426355001411 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 426355001412 dimerization interface [polypeptide binding]; other site 426355001413 putative ATP binding site [chemical binding]; other site 426355001414 Domain of unknown function DUF20; Region: UPF0118; pfam01594 426355001415 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 426355001416 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 426355001417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 426355001418 polyphosphate kinase; Provisional; Region: PRK05443 426355001419 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 426355001420 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 426355001421 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 426355001422 putative domain interface [polypeptide binding]; other site 426355001423 putative active site [active] 426355001424 catalytic site [active] 426355001425 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 426355001426 putative domain interface [polypeptide binding]; other site 426355001427 putative active site [active] 426355001428 catalytic site [active] 426355001429 exopolyphosphatase; Region: exo_poly_only; TIGR03706 426355001430 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 426355001431 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355001432 dimer interface [polypeptide binding]; other site 426355001433 putative CheW interface [polypeptide binding]; other site 426355001434 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 426355001435 heme-binding site [chemical binding]; other site 426355001436 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 426355001437 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 426355001438 Malic enzyme, N-terminal domain; Region: malic; pfam00390 426355001439 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 426355001440 putative NAD(P) binding site [chemical binding]; other site 426355001441 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 426355001442 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 426355001443 trimer interface [polypeptide binding]; other site 426355001444 active site 426355001445 substrate binding site [chemical binding]; other site 426355001446 CoA binding site [chemical binding]; other site 426355001447 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 426355001448 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 426355001449 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426355001450 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 426355001451 Probable Catalytic site; other site 426355001452 metal-binding site 426355001453 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 426355001454 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 426355001455 dimer interface [polypeptide binding]; other site 426355001456 anticodon binding site; other site 426355001457 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 426355001458 motif 1; other site 426355001459 dimer interface [polypeptide binding]; other site 426355001460 active site 426355001461 motif 2; other site 426355001462 GAD domain; Region: GAD; pfam02938 426355001463 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 426355001464 active site 426355001465 motif 3; other site 426355001466 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 426355001467 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 426355001468 catalytic site [active] 426355001469 putative active site [active] 426355001470 putative substrate binding site [chemical binding]; other site 426355001471 HRDC domain; Region: HRDC; pfam00570 426355001472 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 426355001473 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 426355001474 Trp docking motif [polypeptide binding]; other site 426355001475 dimer interface [polypeptide binding]; other site 426355001476 active site 426355001477 small subunit binding site [polypeptide binding]; other site 426355001478 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 426355001479 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 426355001480 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355001481 substrate binding pocket [chemical binding]; other site 426355001482 membrane-bound complex binding site; other site 426355001483 hinge residues; other site 426355001484 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 426355001485 catalytic center binding site [active] 426355001486 ATP binding site [chemical binding]; other site 426355001487 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 426355001488 homooctamer interface [polypeptide binding]; other site 426355001489 active site 426355001490 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 426355001491 dihydropteroate synthase; Region: DHPS; TIGR01496 426355001492 substrate binding pocket [chemical binding]; other site 426355001493 dimer interface [polypeptide binding]; other site 426355001494 inhibitor binding site; inhibition site 426355001495 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 426355001496 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355001497 FeS/SAM binding site; other site 426355001498 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 426355001499 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 426355001500 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 426355001501 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 426355001502 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 426355001503 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 426355001504 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355001505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355001506 active site 426355001507 phosphorylation site [posttranslational modification] 426355001508 intermolecular recognition site; other site 426355001509 dimerization interface [polypeptide binding]; other site 426355001510 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355001511 DNA binding site [nucleotide binding] 426355001512 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355001513 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355001514 dimerization interface [polypeptide binding]; other site 426355001515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355001516 dimer interface [polypeptide binding]; other site 426355001517 phosphorylation site [posttranslational modification] 426355001518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355001519 ATP binding site [chemical binding]; other site 426355001520 Mg2+ binding site [ion binding]; other site 426355001521 G-X-G motif; other site 426355001522 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 426355001523 domain_subunit interface; other site 426355001524 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 426355001525 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 426355001526 FTR, proximal lobe; Region: FTR_C; pfam02741 426355001527 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 426355001528 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426355001529 active site 426355001530 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426355001531 molybdopterin cofactor binding site; other site 426355001532 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 426355001533 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 426355001534 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 426355001535 NADP binding site [chemical binding]; other site 426355001536 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426355001537 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 426355001538 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 426355001539 trimer interface I [polypeptide binding]; other site 426355001540 putative substrate binding pocket [chemical binding]; other site 426355001541 trimer interface II [polypeptide binding]; other site 426355001542 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 426355001543 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426355001544 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 426355001545 formaldehyde-activating enzyme; Region: one_C_fae; TIGR03126 426355001546 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 426355001547 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 426355001548 ring oligomerisation interface [polypeptide binding]; other site 426355001549 ATP/Mg binding site [chemical binding]; other site 426355001550 stacking interactions; other site 426355001551 hinge regions; other site 426355001552 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 426355001553 oligomerisation interface [polypeptide binding]; other site 426355001554 mobile loop; other site 426355001555 roof hairpin; other site 426355001556 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 426355001557 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 426355001558 oligomer interface [polypeptide binding]; other site 426355001559 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355001560 PAS domain; Region: PAS_9; pfam13426 426355001561 putative active site [active] 426355001562 heme pocket [chemical binding]; other site 426355001563 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426355001564 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355001565 dimer interface [polypeptide binding]; other site 426355001566 putative CheW interface [polypeptide binding]; other site 426355001567 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426355001568 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 426355001569 putative active site [active] 426355001570 putative metal binding site [ion binding]; other site 426355001571 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426355001572 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 426355001573 ATP binding site [chemical binding]; other site 426355001574 putative Mg++ binding site [ion binding]; other site 426355001575 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426355001576 nucleotide binding region [chemical binding]; other site 426355001577 ATP-binding site [chemical binding]; other site 426355001578 DEAD/H associated; Region: DEAD_assoc; pfam08494 426355001579 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 426355001580 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 426355001581 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 426355001582 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 426355001583 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 426355001584 putative molybdopterin cofactor binding site [chemical binding]; other site 426355001585 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 426355001586 putative molybdopterin cofactor binding site; other site 426355001587 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 426355001588 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 426355001589 quinone interaction residues [chemical binding]; other site 426355001590 active site 426355001591 catalytic residues [active] 426355001592 FMN binding site [chemical binding]; other site 426355001593 substrate binding site [chemical binding]; other site 426355001594 Protein of unknown function (DUF952); Region: DUF952; cl01393 426355001595 Predicted transcriptional regulator [Transcription]; Region: COG2932 426355001596 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 426355001597 Catalytic site [active] 426355001598 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 426355001599 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355001600 dimer interface [polypeptide binding]; other site 426355001601 phosphorylation site [posttranslational modification] 426355001602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355001603 ATP binding site [chemical binding]; other site 426355001604 Mg2+ binding site [ion binding]; other site 426355001605 G-X-G motif; other site 426355001606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 426355001607 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 426355001608 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 426355001609 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 426355001610 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 426355001611 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 426355001612 OstA-like protein; Region: OstA; cl00844 426355001613 Organic solvent tolerance protein; Region: OstA_C; pfam04453 426355001614 Predicted permeases [General function prediction only]; Region: COG0795 426355001615 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 426355001616 Predicted permeases [General function prediction only]; Region: COG0795 426355001617 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 426355001618 multifunctional aminopeptidase A; Provisional; Region: PRK00913 426355001619 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 426355001620 interface (dimer of trimers) [polypeptide binding]; other site 426355001621 Substrate-binding/catalytic site; other site 426355001622 Zn-binding sites [ion binding]; other site 426355001623 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 426355001624 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426355001625 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 426355001626 acyl-activating enzyme (AAE) consensus motif; other site 426355001627 putative AMP binding site [chemical binding]; other site 426355001628 putative active site [active] 426355001629 putative CoA binding site [chemical binding]; other site 426355001630 TMAO/DMSO reductase; Reviewed; Region: PRK05363 426355001631 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 426355001632 Moco binding site; other site 426355001633 metal coordination site [ion binding]; other site 426355001634 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355001635 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355001636 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 426355001637 putative effector binding pocket; other site 426355001638 dimerization interface [polypeptide binding]; other site 426355001639 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 426355001640 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426355001641 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 426355001642 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 426355001643 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 426355001644 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 426355001645 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 426355001646 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 426355001647 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 426355001648 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426355001649 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 426355001650 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 426355001651 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426355001652 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 426355001653 IMP binding site; other site 426355001654 dimer interface [polypeptide binding]; other site 426355001655 partial ornithine binding site; other site 426355001656 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 426355001657 pseudoazurin; Region: pseudoazurin; TIGR02375 426355001658 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 426355001659 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 426355001660 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 426355001661 catalytic site [active] 426355001662 subunit interface [polypeptide binding]; other site 426355001663 Yqey-like protein; Region: YqeY; pfam09424 426355001664 DNA primase; Validated; Region: dnaG; PRK05667 426355001665 CHC2 zinc finger; Region: zf-CHC2; pfam01807 426355001666 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 426355001667 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 426355001668 active site 426355001669 metal binding site [ion binding]; metal-binding site 426355001670 interdomain interaction site; other site 426355001671 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 426355001672 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 426355001673 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 426355001674 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 426355001675 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 426355001676 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355001677 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 426355001678 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426355001679 DNA binding residues [nucleotide binding] 426355001680 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426355001681 cyclase homology domain; Region: CHD; cd07302 426355001682 nucleotidyl binding site; other site 426355001683 metal binding site [ion binding]; metal-binding site 426355001684 dimer interface [polypeptide binding]; other site 426355001685 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355001686 active site 426355001687 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 426355001688 binding surface 426355001689 TPR motif; other site 426355001690 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 426355001691 catalytic motif [active] 426355001692 Catalytic residue [active] 426355001693 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426355001694 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 426355001695 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 426355001696 thiS-thiF/thiG interaction site; other site 426355001697 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 426355001698 ThiS interaction site; other site 426355001699 putative active site [active] 426355001700 tetramer interface [polypeptide binding]; other site 426355001701 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 426355001702 thiamine phosphate binding site [chemical binding]; other site 426355001703 active site 426355001704 pyrophosphate binding site [ion binding]; other site 426355001705 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 426355001706 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 426355001707 active site 426355001708 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 426355001709 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 426355001710 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 426355001711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 426355001712 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 426355001713 Uncharacterized conserved protein [Function unknown]; Region: COG2308 426355001714 hypothetical protein; Reviewed; Region: PRK00024 426355001715 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 426355001716 MPN+ (JAMM) motif; other site 426355001717 Zinc-binding site [ion binding]; other site 426355001718 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 426355001719 active site 426355001720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 426355001721 salicylate hydroxylase; Provisional; Region: PRK08163 426355001722 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 426355001723 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 426355001724 Uncharacterized conserved protein [Function unknown]; Region: COG2128 426355001725 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 426355001726 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 426355001727 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426355001728 ATP binding site [chemical binding]; other site 426355001729 putative Mg++ binding site [ion binding]; other site 426355001730 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426355001731 nucleotide binding region [chemical binding]; other site 426355001732 ATP-binding site [chemical binding]; other site 426355001733 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 426355001734 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 426355001735 CoenzymeA binding site [chemical binding]; other site 426355001736 subunit interaction site [polypeptide binding]; other site 426355001737 PHB binding site; other site 426355001738 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 426355001739 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 426355001740 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 426355001741 putative active site [active] 426355001742 putative CoA binding site [chemical binding]; other site 426355001743 nudix motif; other site 426355001744 metal binding site [ion binding]; metal-binding site 426355001745 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 426355001746 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 426355001747 active site 426355001748 NTP binding site [chemical binding]; other site 426355001749 metal binding triad [ion binding]; metal-binding site 426355001750 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14736 426355001751 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 426355001752 gamma subunit interface [polypeptide binding]; other site 426355001753 epsilon subunit interface [polypeptide binding]; other site 426355001754 LBP interface [polypeptide binding]; other site 426355001755 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 426355001756 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 426355001757 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 426355001758 alpha subunit interaction interface [polypeptide binding]; other site 426355001759 Walker A motif; other site 426355001760 ATP binding site [chemical binding]; other site 426355001761 Walker B motif; other site 426355001762 inhibitor binding site; inhibition site 426355001763 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 426355001764 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 426355001765 core domain interface [polypeptide binding]; other site 426355001766 delta subunit interface [polypeptide binding]; other site 426355001767 epsilon subunit interface [polypeptide binding]; other site 426355001768 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 426355001769 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 426355001770 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 426355001771 beta subunit interaction interface [polypeptide binding]; other site 426355001772 Walker A motif; other site 426355001773 ATP binding site [chemical binding]; other site 426355001774 Walker B motif; other site 426355001775 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 426355001776 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 426355001777 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 426355001778 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 426355001779 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 426355001780 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 426355001781 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 426355001782 putative catalytic residue [active] 426355001783 argininosuccinate synthase; Provisional; Region: PRK13820 426355001784 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 426355001785 ANP binding site [chemical binding]; other site 426355001786 Substrate Binding Site II [chemical binding]; other site 426355001787 Substrate Binding Site I [chemical binding]; other site 426355001788 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 426355001789 Transglycosylase; Region: Transgly; cl17702 426355001790 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 426355001791 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 426355001792 substrate binding pocket [chemical binding]; other site 426355001793 chain length determination region; other site 426355001794 substrate-Mg2+ binding site; other site 426355001795 catalytic residues [active] 426355001796 aspartate-rich region 1; other site 426355001797 active site lid residues [active] 426355001798 aspartate-rich region 2; other site 426355001799 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426355001800 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 426355001801 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 426355001802 TM-ABC transporter signature motif; other site 426355001803 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 426355001804 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 426355001805 Walker A/P-loop; other site 426355001806 ATP binding site [chemical binding]; other site 426355001807 Q-loop/lid; other site 426355001808 ABC transporter signature motif; other site 426355001809 Walker B; other site 426355001810 D-loop; other site 426355001811 H-loop/switch region; other site 426355001812 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 426355001813 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 426355001814 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 426355001815 putative ligand binding site [chemical binding]; other site 426355001816 classical (c) SDRs; Region: SDR_c; cd05233 426355001817 NAD(P) binding site [chemical binding]; other site 426355001818 active site 426355001819 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355001820 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355001821 ligand binding site [chemical binding]; other site 426355001822 flexible hinge region; other site 426355001823 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 426355001824 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 426355001825 nucleophile elbow; other site 426355001826 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426355001827 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426355001828 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 426355001829 MutS domain I; Region: MutS_I; pfam01624 426355001830 MutS domain II; Region: MutS_II; pfam05188 426355001831 MutS domain III; Region: MutS_III; pfam05192 426355001832 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 426355001833 Walker A/P-loop; other site 426355001834 ATP binding site [chemical binding]; other site 426355001835 Q-loop/lid; other site 426355001836 ABC transporter signature motif; other site 426355001837 Walker B; other site 426355001838 D-loop; other site 426355001839 H-loop/switch region; other site 426355001840 response regulator; Provisional; Region: PRK13435 426355001841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355001842 active site 426355001843 phosphorylation site [posttranslational modification] 426355001844 intermolecular recognition site; other site 426355001845 dimerization interface [polypeptide binding]; other site 426355001846 PAS domain; Region: PAS_9; pfam13426 426355001847 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355001848 putative active site [active] 426355001849 heme pocket [chemical binding]; other site 426355001850 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355001851 Histidine kinase; Region: HisKA_2; pfam07568 426355001852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 426355001853 ATP binding site [chemical binding]; other site 426355001854 Mg2+ binding site [ion binding]; other site 426355001855 G-X-G motif; other site 426355001856 muropeptide transporter; Validated; Region: ampG; cl17669 426355001857 EcsC protein family; Region: EcsC; pfam12787 426355001858 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 426355001859 MgtC family; Region: MgtC; pfam02308 426355001860 threonine dehydratase; Reviewed; Region: PRK09224 426355001861 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 426355001862 tetramer interface [polypeptide binding]; other site 426355001863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355001864 catalytic residue [active] 426355001865 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 426355001866 putative Ile/Val binding site [chemical binding]; other site 426355001867 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 426355001868 putative Ile/Val binding site [chemical binding]; other site 426355001869 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 426355001870 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 426355001871 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 426355001872 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 426355001873 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 426355001874 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 426355001875 tetramer interface [polypeptide binding]; other site 426355001876 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 426355001877 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355001878 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 426355001879 dimerization interface [polypeptide binding]; other site 426355001880 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 426355001881 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 426355001882 tetramer interface [polypeptide binding]; other site 426355001883 heme binding pocket [chemical binding]; other site 426355001884 Cupin domain; Region: Cupin_2; pfam07883 426355001885 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 426355001886 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 426355001887 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 426355001888 putative active site [active] 426355001889 catalytic triad [active] 426355001890 putative dimer interface [polypeptide binding]; other site 426355001891 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 426355001892 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 426355001893 Transporter associated domain; Region: CorC_HlyC; smart01091 426355001894 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 426355001895 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 426355001896 PhoH-like protein; Region: PhoH; pfam02562 426355001897 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 426355001898 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 426355001899 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355001900 FeS/SAM binding site; other site 426355001901 TRAM domain; Region: TRAM; pfam01938 426355001902 L-lactate permease; Region: Lactate_perm; cl00701 426355001903 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 426355001904 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 426355001905 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 426355001906 putative acyl-acceptor binding pocket; other site 426355001907 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 426355001908 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 426355001909 Glycoprotease family; Region: Peptidase_M22; pfam00814 426355001910 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 426355001911 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 426355001912 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 426355001913 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 426355001914 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426355001915 motif II; other site 426355001916 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 426355001917 amidase; Provisional; Region: PRK09201 426355001918 Amidase; Region: Amidase; cl11426 426355001919 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 426355001920 SnoaL-like domain; Region: SnoaL_3; pfam13474 426355001921 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426355001922 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 426355001923 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426355001924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355001925 dimer interface [polypeptide binding]; other site 426355001926 conserved gate region; other site 426355001927 putative PBP binding loops; other site 426355001928 ABC-ATPase subunit interface; other site 426355001929 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 426355001930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355001931 dimer interface [polypeptide binding]; other site 426355001932 conserved gate region; other site 426355001933 putative PBP binding loops; other site 426355001934 ABC-ATPase subunit interface; other site 426355001935 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 426355001936 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355001937 Walker A/P-loop; other site 426355001938 ATP binding site [chemical binding]; other site 426355001939 Q-loop/lid; other site 426355001940 ABC transporter signature motif; other site 426355001941 Walker B; other site 426355001942 D-loop; other site 426355001943 H-loop/switch region; other site 426355001944 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426355001945 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355001946 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 426355001947 Walker A/P-loop; other site 426355001948 ATP binding site [chemical binding]; other site 426355001949 Q-loop/lid; other site 426355001950 ABC transporter signature motif; other site 426355001951 Walker B; other site 426355001952 D-loop; other site 426355001953 H-loop/switch region; other site 426355001954 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 426355001955 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 426355001956 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355001957 DNA-binding site [nucleotide binding]; DNA binding site 426355001958 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426355001959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355001960 homodimer interface [polypeptide binding]; other site 426355001961 catalytic residue [active] 426355001962 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 426355001963 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 426355001964 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 426355001965 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 426355001966 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 426355001967 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426355001968 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 426355001969 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 426355001970 generic binding surface II; other site 426355001971 generic binding surface I; other site 426355001972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355001973 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426355001974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355001975 citrate-proton symporter; Provisional; Region: PRK15075 426355001976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355001977 putative substrate translocation pore; other site 426355001978 Ribosome modulation factor; Region: RMF; cl01207 426355001979 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 426355001980 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355001981 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 426355001982 putative NAD(P) binding site [chemical binding]; other site 426355001983 active site 426355001984 putative substrate binding site [chemical binding]; other site 426355001985 Cytochrome c2 [Energy production and conversion]; Region: COG3474 426355001986 Transcriptional regulators [Transcription]; Region: MarR; COG1846 426355001987 MarR family; Region: MarR; pfam01047 426355001988 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 426355001989 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426355001990 active site 426355001991 DNA binding site [nucleotide binding] 426355001992 Int/Topo IB signature motif; other site 426355001993 shikimate kinase; Provisional; Region: PRK13946 426355001994 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 426355001995 ADP binding site [chemical binding]; other site 426355001996 magnesium binding site [ion binding]; other site 426355001997 putative shikimate binding site; other site 426355001998 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 426355001999 active site 426355002000 dimer interface [polypeptide binding]; other site 426355002001 metal binding site [ion binding]; metal-binding site 426355002002 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 426355002003 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 426355002004 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 426355002005 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 426355002006 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 426355002007 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 426355002008 dimer interface [polypeptide binding]; other site 426355002009 ADP-ribose binding site [chemical binding]; other site 426355002010 active site 426355002011 nudix motif; other site 426355002012 metal binding site [ion binding]; metal-binding site 426355002013 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 426355002014 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 426355002015 active site 426355002016 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 426355002017 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 426355002018 homodimer interface [polypeptide binding]; other site 426355002019 substrate-cofactor binding pocket; other site 426355002020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355002021 catalytic residue [active] 426355002022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355002023 active site 426355002024 phosphorylation site [posttranslational modification] 426355002025 intermolecular recognition site; other site 426355002026 dimerization interface [polypeptide binding]; other site 426355002027 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 426355002028 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426355002029 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 426355002030 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426355002031 catalytic residue [active] 426355002032 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 426355002033 putative ABC transporter; Region: ycf24; CHL00085 426355002034 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 426355002035 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 426355002036 Walker A/P-loop; other site 426355002037 ATP binding site [chemical binding]; other site 426355002038 Q-loop/lid; other site 426355002039 ABC transporter signature motif; other site 426355002040 Walker B; other site 426355002041 D-loop; other site 426355002042 H-loop/switch region; other site 426355002043 FeS assembly protein SufD; Region: sufD; TIGR01981 426355002044 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 426355002045 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 426355002046 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 426355002047 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426355002048 catalytic residue [active] 426355002049 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 426355002050 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 426355002051 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 426355002052 Walker A/P-loop; other site 426355002053 ATP binding site [chemical binding]; other site 426355002054 Q-loop/lid; other site 426355002055 ABC transporter signature motif; other site 426355002056 Walker B; other site 426355002057 D-loop; other site 426355002058 H-loop/switch region; other site 426355002059 ABC-2 type transporter; Region: ABC2_membrane; cl17235 426355002060 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 426355002061 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426355002062 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426355002063 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 426355002064 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 426355002065 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 426355002066 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 426355002067 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 426355002068 putative MPT binding site; other site 426355002069 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 426355002070 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 426355002071 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426355002072 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 426355002073 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 426355002074 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 426355002075 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 426355002076 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 426355002077 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 426355002078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 426355002079 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 426355002080 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 426355002081 catalytic residues [active] 426355002082 Protein of unknown function (DUF721); Region: DUF721; cl02324 426355002083 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 426355002084 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 426355002085 minor groove reading motif; other site 426355002086 helix-hairpin-helix signature motif; other site 426355002087 substrate binding pocket [chemical binding]; other site 426355002088 active site 426355002089 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 426355002090 DNA binding and oxoG recognition site [nucleotide binding] 426355002091 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 426355002092 DNA methylase; Region: N6_N4_Mtase; pfam01555 426355002093 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 426355002094 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 426355002095 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 426355002096 ABC transporter ATPase component; Reviewed; Region: PRK11147 426355002097 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426355002098 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426355002099 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 426355002100 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 426355002101 active site 426355002102 Zn binding site [ion binding]; other site 426355002103 P-loop containing region of AAA domain; Region: AAA_29; cl17516 426355002104 AAA domain; Region: AAA_23; pfam13476 426355002105 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 426355002106 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426355002107 active site 426355002108 metal binding site [ion binding]; metal-binding site 426355002109 DNA binding site [nucleotide binding] 426355002110 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 426355002111 putative catalytic site [active] 426355002112 putative metal binding site [ion binding]; other site 426355002113 putative phosphate binding site [ion binding]; other site 426355002114 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 426355002115 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 426355002116 putative active site [active] 426355002117 catalytic site [active] 426355002118 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 426355002119 putative active site [active] 426355002120 catalytic site [active] 426355002121 enoyl-CoA hydratase; Validated; Region: PRK08139 426355002122 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426355002123 substrate binding site [chemical binding]; other site 426355002124 oxyanion hole (OAH) forming residues; other site 426355002125 trimer interface [polypeptide binding]; other site 426355002126 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 426355002127 ligand binding site [chemical binding]; other site 426355002128 active site 426355002129 UGI interface [polypeptide binding]; other site 426355002130 catalytic site [active] 426355002131 ferrochelatase; Reviewed; Region: hemH; PRK00035 426355002132 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 426355002133 C-terminal domain interface [polypeptide binding]; other site 426355002134 active site 426355002135 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 426355002136 active site 426355002137 N-terminal domain interface [polypeptide binding]; other site 426355002138 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 426355002139 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 426355002140 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 426355002141 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426355002142 ATP binding site [chemical binding]; other site 426355002143 putative Mg++ binding site [ion binding]; other site 426355002144 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 426355002145 SEC-C motif; Region: SEC-C; pfam02810 426355002146 AAA domain; Region: AAA_26; pfam13500 426355002147 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 426355002148 potassium uptake protein; Region: kup; TIGR00794 426355002149 K+ potassium transporter; Region: K_trans; pfam02705 426355002150 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 426355002151 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 426355002152 homotetramer interface [polypeptide binding]; other site 426355002153 ligand binding site [chemical binding]; other site 426355002154 catalytic site [active] 426355002155 NAD binding site [chemical binding]; other site 426355002156 PAS fold; Region: PAS_7; pfam12860 426355002157 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 426355002158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355002159 dimer interface [polypeptide binding]; other site 426355002160 phosphorylation site [posttranslational modification] 426355002161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355002162 ATP binding site [chemical binding]; other site 426355002163 Mg2+ binding site [ion binding]; other site 426355002164 G-X-G motif; other site 426355002165 H+ Antiporter protein; Region: 2A0121; TIGR00900 426355002166 translocation protein TolB; Provisional; Region: tolB; PRK05137 426355002167 TolB amino-terminal domain; Region: TolB_N; pfam04052 426355002168 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 426355002169 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 426355002170 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 426355002171 TolA protein; Region: tolA_full; TIGR02794 426355002172 TolR protein; Region: tolR; TIGR02801 426355002173 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 426355002174 TolQ protein; Region: tolQ; TIGR02796 426355002175 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 426355002176 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 426355002177 active site 426355002178 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 426355002179 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 426355002180 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 426355002181 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 426355002182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355002183 Walker A motif; other site 426355002184 ATP binding site [chemical binding]; other site 426355002185 Walker B motif; other site 426355002186 arginine finger; other site 426355002187 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 426355002188 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355002189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355002190 active site 426355002191 phosphorylation site [posttranslational modification] 426355002192 intermolecular recognition site; other site 426355002193 dimerization interface [polypeptide binding]; other site 426355002194 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355002195 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355002196 metal binding site [ion binding]; metal-binding site 426355002197 active site 426355002198 I-site; other site 426355002199 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426355002200 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355002201 DNA binding residues [nucleotide binding] 426355002202 dimerization interface [polypeptide binding]; other site 426355002203 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 426355002204 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 426355002205 active site 426355002206 DNA binding site [nucleotide binding] 426355002207 Int/Topo IB signature motif; other site 426355002208 catalytic residues [active] 426355002209 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 426355002210 putative ADP-binding pocket [chemical binding]; other site 426355002211 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355002212 Predicted methyltransferase [General function prediction only]; Region: COG3897 426355002213 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 426355002214 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 426355002215 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 426355002216 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 426355002217 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 426355002218 putative ligand binding site [chemical binding]; other site 426355002219 NAD binding site [chemical binding]; other site 426355002220 catalytic site [active] 426355002221 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 426355002222 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 426355002223 substrate binding site [chemical binding]; other site 426355002224 ligand binding site [chemical binding]; other site 426355002225 Protein of unknown function, DUF393; Region: DUF393; pfam04134 426355002226 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 426355002227 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 426355002228 Double zinc ribbon; Region: DZR; pfam12773 426355002229 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 426355002230 tartrate dehydrogenase; Region: TTC; TIGR02089 426355002231 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355002232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355002233 active site 426355002234 phosphorylation site [posttranslational modification] 426355002235 intermolecular recognition site; other site 426355002236 dimerization interface [polypeptide binding]; other site 426355002237 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355002238 DNA binding site [nucleotide binding] 426355002239 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 426355002240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355002241 ATP binding site [chemical binding]; other site 426355002242 Mg2+ binding site [ion binding]; other site 426355002243 G-X-G motif; other site 426355002244 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 426355002245 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 426355002246 glutamate racemase; Provisional; Region: PRK00865 426355002247 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 426355002248 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 426355002249 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 426355002250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426355002251 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 426355002252 cyclase homology domain; Region: CHD; cd07302 426355002253 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426355002254 nucleotidyl binding site; other site 426355002255 metal binding site [ion binding]; metal-binding site 426355002256 dimer interface [polypeptide binding]; other site 426355002257 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 426355002258 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 426355002259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355002260 Walker A motif; other site 426355002261 ATP binding site [chemical binding]; other site 426355002262 Walker B motif; other site 426355002263 arginine finger; other site 426355002264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355002265 Walker A motif; other site 426355002266 ATP binding site [chemical binding]; other site 426355002267 Walker B motif; other site 426355002268 arginine finger; other site 426355002269 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 426355002270 Uncharacterized conserved protein [Function unknown]; Region: COG2127 426355002271 Phasin protein; Region: Phasin_2; cl11491 426355002272 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 426355002273 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 426355002274 Sporulation related domain; Region: SPOR; pfam05036 426355002275 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 426355002276 HSP70 interaction site [polypeptide binding]; other site 426355002277 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 426355002278 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426355002279 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426355002280 protein binding site [polypeptide binding]; other site 426355002281 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 426355002282 AAA domain; Region: AAA_23; pfam13476 426355002283 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 426355002284 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426355002285 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 426355002286 dimerization interface [polypeptide binding]; other site 426355002287 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355002288 dimer interface [polypeptide binding]; other site 426355002289 putative CheW interface [polypeptide binding]; other site 426355002290 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 426355002291 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 426355002292 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355002293 dimer interface [polypeptide binding]; other site 426355002294 putative CheW interface [polypeptide binding]; other site 426355002295 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 426355002296 Flavoprotein; Region: Flavoprotein; pfam02441 426355002297 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 426355002298 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14839 426355002299 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 426355002300 catalytic residue [active] 426355002301 putative FPP diphosphate binding site; other site 426355002302 putative FPP binding hydrophobic cleft; other site 426355002303 dimer interface [polypeptide binding]; other site 426355002304 putative IPP diphosphate binding site; other site 426355002305 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 426355002306 excinuclease ABC subunit B; Provisional; Region: PRK05298 426355002307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426355002308 ATP binding site [chemical binding]; other site 426355002309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426355002310 nucleotide binding region [chemical binding]; other site 426355002311 ATP-binding site [chemical binding]; other site 426355002312 Ultra-violet resistance protein B; Region: UvrB; pfam12344 426355002313 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 426355002314 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 426355002315 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 426355002316 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 426355002317 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 426355002318 Trp docking motif [polypeptide binding]; other site 426355002319 active site 426355002320 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 426355002321 O-Antigen ligase; Region: Wzy_C; pfam04932 426355002322 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 426355002323 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 426355002324 substrate binding pocket [chemical binding]; other site 426355002325 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426355002326 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 426355002327 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426355002328 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426355002329 catalytic residue [active] 426355002330 Sporulation related domain; Region: SPOR; cl10051 426355002331 Isochorismatase family; Region: Isochorismatase; pfam00857 426355002332 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 426355002333 catalytic triad [active] 426355002334 conserved cis-peptide bond; other site 426355002335 Leucine rich repeat; Region: LRR_8; pfam13855 426355002336 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 426355002337 phosphopentomutase; Provisional; Region: PRK05362 426355002338 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 426355002339 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 426355002340 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355002341 Walker A/P-loop; other site 426355002342 ATP binding site [chemical binding]; other site 426355002343 Q-loop/lid; other site 426355002344 ABC transporter signature motif; other site 426355002345 Walker B; other site 426355002346 D-loop; other site 426355002347 H-loop/switch region; other site 426355002348 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426355002349 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355002350 Walker A/P-loop; other site 426355002351 ATP binding site [chemical binding]; other site 426355002352 Q-loop/lid; other site 426355002353 ABC transporter signature motif; other site 426355002354 Walker B; other site 426355002355 D-loop; other site 426355002356 H-loop/switch region; other site 426355002357 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426355002358 Uncharacterized conserved protein [Function unknown]; Region: COG3334 426355002359 flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795 426355002360 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 426355002361 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK12785 426355002362 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 426355002363 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 426355002364 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 426355002365 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 426355002366 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 426355002367 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 426355002368 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786 426355002369 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 426355002370 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 426355002371 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 426355002372 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 426355002373 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 426355002374 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 426355002375 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 426355002376 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 426355002377 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 426355002378 active site 426355002379 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 426355002380 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 426355002381 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 426355002382 DHHW protein; Region: DHHW; pfam14286 426355002383 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 426355002384 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 426355002385 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 426355002386 putative dimer interface [polypeptide binding]; other site 426355002387 N-terminal domain interface [polypeptide binding]; other site 426355002388 putative substrate binding pocket (H-site) [chemical binding]; other site 426355002389 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 426355002390 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 426355002391 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 426355002392 Uncharacterized conserved protein [Function unknown]; Region: COG2835 426355002393 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 426355002394 primosome assembly protein PriA; Validated; Region: PRK05580 426355002395 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426355002396 ATP binding site [chemical binding]; other site 426355002397 putative Mg++ binding site [ion binding]; other site 426355002398 helicase superfamily c-terminal domain; Region: HELICc; smart00490 426355002399 nucleotide binding region [chemical binding]; other site 426355002400 ATP-binding site [chemical binding]; other site 426355002401 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 426355002402 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 426355002403 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426355002404 LNS2 (Lipin/Ned1/Smp2); Region: LNS2; pfam08235 426355002405 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 426355002406 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 426355002407 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 426355002408 Domain of unknown function DUF21; Region: DUF21; pfam01595 426355002409 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 426355002410 Transporter associated domain; Region: CorC_HlyC; smart01091 426355002411 aminotransferase; Provisional; Region: PRK06105 426355002412 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426355002413 inhibitor-cofactor binding pocket; inhibition site 426355002414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355002415 catalytic residue [active] 426355002416 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 426355002417 catalytic residues [active] 426355002418 dimer interface [polypeptide binding]; other site 426355002419 ATP12 chaperone protein; Region: ATP12; cl02228 426355002420 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 426355002421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426355002422 motif II; other site 426355002423 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426355002424 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 426355002425 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426355002426 RNA binding surface [nucleotide binding]; other site 426355002427 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 426355002428 active site 426355002429 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 426355002430 nudix motif; other site 426355002431 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 426355002432 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426355002433 N-terminal plug; other site 426355002434 ligand-binding site [chemical binding]; other site 426355002435 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 426355002436 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 426355002437 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 426355002438 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 426355002439 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 426355002440 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 426355002441 MarR family; Region: MarR_2; pfam12802 426355002442 Response regulator receiver domain; Region: Response_reg; pfam00072 426355002443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355002444 active site 426355002445 phosphorylation site [posttranslational modification] 426355002446 intermolecular recognition site; other site 426355002447 dimerization interface [polypeptide binding]; other site 426355002448 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 426355002449 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426355002450 inhibitor-cofactor binding pocket; inhibition site 426355002451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355002452 catalytic residue [active] 426355002453 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 426355002454 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426355002455 catalytic residue [active] 426355002456 OsmC-like protein; Region: OsmC; pfam02566 426355002457 Methyltransferase domain; Region: Methyltransf_31; pfam13847 426355002458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355002459 S-adenosylmethionine binding site [chemical binding]; other site 426355002460 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 426355002461 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 426355002462 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 426355002463 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 426355002464 glutathione synthetase; Provisional; Region: PRK05246 426355002465 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 426355002466 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 426355002467 Predicted integral membrane protein [Function unknown]; Region: COG5436 426355002468 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 426355002469 Transglycosylase; Region: Transgly; pfam00912 426355002470 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 426355002471 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 426355002472 hypothetical protein; Provisional; Region: PRK05170 426355002473 RNA polymerase sigma factor; Provisional; Region: PRK12512 426355002474 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355002475 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 426355002476 DNA binding residues [nucleotide binding] 426355002477 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 426355002478 Creatinine amidohydrolase; Region: Creatininase; pfam02633 426355002479 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 426355002480 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 426355002481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355002482 active site 426355002483 phosphorylation site [posttranslational modification] 426355002484 intermolecular recognition site; other site 426355002485 dimerization interface [polypeptide binding]; other site 426355002486 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 426355002487 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 426355002488 active site 426355002489 Riboflavin kinase; Region: Flavokinase; smart00904 426355002490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 426355002491 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 426355002492 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 426355002493 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 426355002494 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 426355002495 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 426355002496 putative acyl-acceptor binding pocket; other site 426355002497 CCC1-related family of proteins; Region: CCC1_like; cl00278 426355002498 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 426355002499 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426355002500 active site 426355002501 metal binding site [ion binding]; metal-binding site 426355002502 amidase; Provisional; Region: PRK07487 426355002503 Amidase; Region: Amidase; cl11426 426355002504 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 426355002505 hypothetical protein; Provisional; Region: PRK07338 426355002506 metal binding site [ion binding]; metal-binding site 426355002507 dimer interface [polypeptide binding]; other site 426355002508 Uncharacterized conserved protein [Function unknown]; Region: COG5476 426355002509 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 426355002510 MlrC C-terminus; Region: MlrC_C; pfam07171 426355002511 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 426355002512 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 426355002513 active site 426355002514 hypothetical protein; Validated; Region: PRK07586 426355002515 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426355002516 PYR/PP interface [polypeptide binding]; other site 426355002517 dimer interface [polypeptide binding]; other site 426355002518 TPP binding site [chemical binding]; other site 426355002519 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 426355002520 TPP-binding site [chemical binding]; other site 426355002521 dimer interface [polypeptide binding]; other site 426355002522 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 426355002523 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426355002524 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 426355002525 Amidase; Region: Amidase; cl11426 426355002526 RNA polymerase sigma factor; Provisional; Region: PRK12547 426355002527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355002528 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426355002529 DNA binding residues [nucleotide binding] 426355002530 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 426355002531 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 426355002532 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 426355002533 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 426355002534 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 426355002535 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 426355002536 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426355002537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355002538 NAD(P) binding site [chemical binding]; other site 426355002539 active site 426355002540 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 426355002541 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 426355002542 putative acyl-acceptor binding pocket; other site 426355002543 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426355002544 acyl-activating enzyme (AAE) consensus motif; other site 426355002545 AMP binding site [chemical binding]; other site 426355002546 active site 426355002547 CoA binding site [chemical binding]; other site 426355002548 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 426355002549 Transglycosylase; Region: Transgly; pfam00912 426355002550 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 426355002551 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 426355002552 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 426355002553 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426355002554 Methyltransferase domain; Region: Methyltransf_11; pfam08241 426355002555 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 426355002556 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426355002557 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355002558 malate dehydrogenase; Reviewed; Region: PRK06223 426355002559 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 426355002560 NAD(P) binding site [chemical binding]; other site 426355002561 dimer interface [polypeptide binding]; other site 426355002562 tetramer (dimer of dimers) interface [polypeptide binding]; other site 426355002563 substrate binding site [chemical binding]; other site 426355002564 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 426355002565 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 426355002566 CoA-ligase; Region: Ligase_CoA; pfam00549 426355002567 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 426355002568 CoA binding domain; Region: CoA_binding; smart00881 426355002569 CoA-ligase; Region: Ligase_CoA; pfam00549 426355002570 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 426355002571 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 426355002572 TPP-binding site [chemical binding]; other site 426355002573 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 426355002574 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 426355002575 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426355002576 E3 interaction surface; other site 426355002577 lipoyl attachment site [posttranslational modification]; other site 426355002578 e3 binding domain; Region: E3_binding; pfam02817 426355002579 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 426355002580 short chain dehydrogenase; Provisional; Region: PRK06123 426355002581 classical (c) SDRs; Region: SDR_c; cd05233 426355002582 NAD(P) binding site [chemical binding]; other site 426355002583 active site 426355002584 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 426355002585 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 426355002586 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426355002587 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 426355002588 Response regulator receiver domain; Region: Response_reg; pfam00072 426355002589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355002590 active site 426355002591 phosphorylation site [posttranslational modification] 426355002592 intermolecular recognition site; other site 426355002593 dimerization interface [polypeptide binding]; other site 426355002594 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 426355002595 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426355002596 active site 426355002597 DNA binding site [nucleotide binding] 426355002598 Int/Topo IB signature motif; other site 426355002599 Uncharacterized conserved protein [Function unknown]; Region: COG1742 426355002600 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 426355002601 active site 426355002602 putative DNA-binding cleft [nucleotide binding]; other site 426355002603 dimer interface [polypeptide binding]; other site 426355002604 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 426355002605 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 426355002606 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 426355002607 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 426355002608 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 426355002609 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 426355002610 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 426355002611 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 426355002612 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 426355002613 homotrimer interaction site [polypeptide binding]; other site 426355002614 putative active site [active] 426355002615 Predicted membrane protein [Function unknown]; Region: COG2261 426355002616 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 426355002617 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 426355002618 RNase E interface [polypeptide binding]; other site 426355002619 trimer interface [polypeptide binding]; other site 426355002620 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 426355002621 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 426355002622 RNase E interface [polypeptide binding]; other site 426355002623 trimer interface [polypeptide binding]; other site 426355002624 active site 426355002625 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 426355002626 putative nucleic acid binding region [nucleotide binding]; other site 426355002627 G-X-X-G motif; other site 426355002628 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 426355002629 RNA binding site [nucleotide binding]; other site 426355002630 domain interface; other site 426355002631 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 426355002632 16S/18S rRNA binding site [nucleotide binding]; other site 426355002633 S13e-L30e interaction site [polypeptide binding]; other site 426355002634 25S rRNA binding site [nucleotide binding]; other site 426355002635 amino acid transporter; Region: 2A0306; TIGR00909 426355002636 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 426355002637 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 426355002638 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 426355002639 active site 426355002640 cosubstrate binding site; other site 426355002641 substrate binding site [chemical binding]; other site 426355002642 catalytic site [active] 426355002643 short chain dehydrogenase; Provisional; Region: PRK07024 426355002644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355002645 NAD(P) binding site [chemical binding]; other site 426355002646 active site 426355002647 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 426355002648 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 426355002649 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 426355002650 Sulfatase; Region: Sulfatase; cl17466 426355002651 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 426355002652 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 426355002653 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 426355002654 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 426355002655 substrate-cofactor binding pocket; other site 426355002656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355002657 catalytic residue [active] 426355002658 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 426355002659 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 426355002660 active site 426355002661 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 426355002662 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 426355002663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355002664 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 426355002665 Enoylreductase; Region: PKS_ER; smart00829 426355002666 NAD(P) binding site [chemical binding]; other site 426355002667 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 426355002668 KR domain; Region: KR; pfam08659 426355002669 putative NADP binding site [chemical binding]; other site 426355002670 active site 426355002671 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 426355002672 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 426355002673 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 426355002674 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 426355002675 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 426355002676 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 426355002677 feedback inhibition sensing region; other site 426355002678 homohexameric interface [polypeptide binding]; other site 426355002679 nucleotide binding site [chemical binding]; other site 426355002680 N-acetyl-L-glutamate binding site [chemical binding]; other site 426355002681 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 426355002682 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 426355002683 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 426355002684 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 426355002685 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355002686 dimerization interface [polypeptide binding]; other site 426355002687 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426355002688 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355002689 dimer interface [polypeptide binding]; other site 426355002690 putative CheW interface [polypeptide binding]; other site 426355002691 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 426355002692 homotrimer interaction site [polypeptide binding]; other site 426355002693 putative active site [active] 426355002694 Transglycosylase SLT domain; Region: SLT_2; pfam13406 426355002695 murein hydrolase B; Provisional; Region: PRK10760; cl17906 426355002696 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426355002697 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 426355002698 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426355002699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355002700 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 426355002701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426355002702 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 426355002703 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 426355002704 substrate binding site [chemical binding]; other site 426355002705 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 426355002706 phosphate binding site [ion binding]; other site 426355002707 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 426355002708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426355002709 Coenzyme A binding pocket [chemical binding]; other site 426355002710 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 426355002711 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355002712 FeS/SAM binding site; other site 426355002713 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 426355002714 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 426355002715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426355002716 Coenzyme A binding pocket [chemical binding]; other site 426355002717 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 426355002718 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 426355002719 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355002720 FeS/SAM binding site; other site 426355002721 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 426355002722 ligand binding site; other site 426355002723 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 426355002724 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 426355002725 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 426355002726 Amidinotransferase; Region: Amidinotransf; cl12043 426355002727 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426355002728 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 426355002729 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 426355002730 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 426355002731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355002732 S-adenosylmethionine binding site [chemical binding]; other site 426355002733 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 426355002734 enolase; Provisional; Region: eno; PRK00077 426355002735 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 426355002736 dimer interface [polypeptide binding]; other site 426355002737 metal binding site [ion binding]; metal-binding site 426355002738 substrate binding pocket [chemical binding]; other site 426355002739 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426355002740 cyclase homology domain; Region: CHD; cd07302 426355002741 nucleotidyl binding site; other site 426355002742 metal binding site [ion binding]; metal-binding site 426355002743 dimer interface [polypeptide binding]; other site 426355002744 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 426355002745 Septum formation initiator; Region: DivIC; cl17659 426355002746 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 426355002747 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 426355002748 tetramer interface [polypeptide binding]; other site 426355002749 TPP-binding site [chemical binding]; other site 426355002750 heterodimer interface [polypeptide binding]; other site 426355002751 phosphorylation loop region [posttranslational modification] 426355002752 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 426355002753 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426355002754 E3 interaction surface; other site 426355002755 lipoyl attachment site [posttranslational modification]; other site 426355002756 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 426355002757 alpha subunit interface [polypeptide binding]; other site 426355002758 TPP binding site [chemical binding]; other site 426355002759 heterodimer interface [polypeptide binding]; other site 426355002760 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 426355002761 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 426355002762 putative active site [active] 426355002763 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426355002764 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 426355002765 E3 interaction surface; other site 426355002766 lipoyl attachment site [posttranslational modification]; other site 426355002767 e3 binding domain; Region: E3_binding; pfam02817 426355002768 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 426355002769 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 426355002770 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 426355002771 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426355002772 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426355002773 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 426355002774 serine racemase; Region: PLN02970 426355002775 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 426355002776 tetramer interface [polypeptide binding]; other site 426355002777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355002778 catalytic residue [active] 426355002779 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 426355002780 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355002781 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355002782 metal binding site [ion binding]; metal-binding site 426355002783 active site 426355002784 I-site; other site 426355002785 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 426355002786 DEAD-like helicases superfamily; Region: DEXDc; smart00487 426355002787 ATP binding site [chemical binding]; other site 426355002788 Mg++ binding site [ion binding]; other site 426355002789 motif III; other site 426355002790 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426355002791 nucleotide binding region [chemical binding]; other site 426355002792 ATP-binding site [chemical binding]; other site 426355002793 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 426355002794 PRC-barrel domain; Region: PRC; pfam05239 426355002795 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 426355002796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355002797 ATP binding site [chemical binding]; other site 426355002798 Mg2+ binding site [ion binding]; other site 426355002799 G-X-G motif; other site 426355002800 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 426355002801 anchoring element; other site 426355002802 dimer interface [polypeptide binding]; other site 426355002803 ATP binding site [chemical binding]; other site 426355002804 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 426355002805 active site 426355002806 metal binding site [ion binding]; metal-binding site 426355002807 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 426355002808 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 426355002809 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 426355002810 active site 426355002811 interdomain interaction site; other site 426355002812 putative metal-binding site [ion binding]; other site 426355002813 nucleotide binding site [chemical binding]; other site 426355002814 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 426355002815 domain I; other site 426355002816 DNA binding groove [nucleotide binding] 426355002817 phosphate binding site [ion binding]; other site 426355002818 domain II; other site 426355002819 domain III; other site 426355002820 nucleotide binding site [chemical binding]; other site 426355002821 catalytic site [active] 426355002822 domain IV; other site 426355002823 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 426355002824 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 426355002825 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 426355002826 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 426355002827 Protein of unknown function (DUF497); Region: DUF497; pfam04365 426355002828 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 426355002829 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 426355002830 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 426355002831 metal coordination site [ion binding]; other site 426355002832 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 426355002833 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 426355002834 Moco binding site; other site 426355002835 Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292 426355002836 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 426355002837 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 426355002838 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 426355002839 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 426355002840 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 426355002841 metal binding site [ion binding]; metal-binding site 426355002842 pantothenate kinase; Provisional; Region: PRK05439 426355002843 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 426355002844 ATP-binding site [chemical binding]; other site 426355002845 CoA-binding site [chemical binding]; other site 426355002846 Mg2+-binding site [ion binding]; other site 426355002847 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 426355002848 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 426355002849 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 426355002850 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 426355002851 active site 426355002852 catalytic triad [active] 426355002853 oxyanion hole [active] 426355002854 switch loop; other site 426355002855 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 426355002856 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 426355002857 Walker A/P-loop; other site 426355002858 ATP binding site [chemical binding]; other site 426355002859 Q-loop/lid; other site 426355002860 ABC transporter signature motif; other site 426355002861 Walker B; other site 426355002862 D-loop; other site 426355002863 H-loop/switch region; other site 426355002864 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 426355002865 FtsX-like permease family; Region: FtsX; pfam02687 426355002866 PAS fold; Region: PAS; pfam00989 426355002867 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355002868 putative active site [active] 426355002869 heme pocket [chemical binding]; other site 426355002870 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 426355002871 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 426355002872 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 426355002873 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 426355002874 inhibitor site; inhibition site 426355002875 active site 426355002876 dimer interface [polypeptide binding]; other site 426355002877 catalytic residue [active] 426355002878 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 426355002879 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 426355002880 FMN binding site [chemical binding]; other site 426355002881 dimer interface [polypeptide binding]; other site 426355002882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426355002883 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426355002884 Cupin domain; Region: Cupin_2; pfam07883 426355002885 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 426355002886 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 426355002887 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 426355002888 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 426355002889 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 426355002890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355002891 S-adenosylmethionine binding site [chemical binding]; other site 426355002892 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 426355002893 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 426355002894 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 426355002895 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 426355002896 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 426355002897 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 426355002898 RNA polymerase sigma factor; Provisional; Region: PRK12547 426355002899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355002900 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426355002901 DNA binding residues [nucleotide binding] 426355002902 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 426355002903 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 426355002904 putative active site [active] 426355002905 putative dimer interface [polypeptide binding]; other site 426355002906 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 426355002907 Subunit I/III interface [polypeptide binding]; other site 426355002908 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 426355002909 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 426355002910 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 426355002911 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 426355002912 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 426355002913 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 426355002914 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 426355002915 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426355002916 molybdopterin cofactor binding site; other site 426355002917 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 426355002918 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 426355002919 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 426355002920 4Fe-4S binding domain; Region: Fer4_2; pfam12797 426355002921 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 426355002922 heme-binding residues [chemical binding]; other site 426355002923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355002924 Walker A/P-loop; other site 426355002925 ATP binding site [chemical binding]; other site 426355002926 Q-loop/lid; other site 426355002927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 426355002928 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 426355002929 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355002930 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 426355002931 putative NAD(P) binding site [chemical binding]; other site 426355002932 active site 426355002933 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355002934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355002935 NAD(P) binding site [chemical binding]; other site 426355002936 active site 426355002937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355002938 Predicted transcriptional regulator [Transcription]; Region: COG1959 426355002939 Transcriptional regulator; Region: Rrf2; pfam02082 426355002940 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 426355002941 pentamer interface [polypeptide binding]; other site 426355002942 dodecaamer interface [polypeptide binding]; other site 426355002943 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 426355002944 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426355002945 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 426355002946 Transcriptional regulator [Transcription]; Region: IclR; COG1414 426355002947 Bacterial transcriptional regulator; Region: IclR; pfam01614 426355002948 enoyl-CoA hydratase; Provisional; Region: PRK06688 426355002949 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426355002950 substrate binding site [chemical binding]; other site 426355002951 oxyanion hole (OAH) forming residues; other site 426355002952 trimer interface [polypeptide binding]; other site 426355002953 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 426355002954 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 426355002955 FMN binding site [chemical binding]; other site 426355002956 substrate binding site [chemical binding]; other site 426355002957 putative catalytic residue [active] 426355002958 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 426355002959 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426355002960 substrate binding site [chemical binding]; other site 426355002961 oxyanion hole (OAH) forming residues; other site 426355002962 trimer interface [polypeptide binding]; other site 426355002963 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 426355002964 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 426355002965 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 426355002966 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 426355002967 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 426355002968 dimer interface [polypeptide binding]; other site 426355002969 active site 426355002970 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 426355002971 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426355002972 active site 426355002973 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 426355002974 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 426355002975 active site 426355002976 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426355002977 TPR motif; other site 426355002978 TPR repeat; Region: TPR_11; pfam13414 426355002979 binding surface 426355002980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426355002981 binding surface 426355002982 TPR motif; other site 426355002983 TPR repeat; Region: TPR_11; pfam13414 426355002984 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 426355002985 ATP-grasp domain; Region: ATP-grasp; pfam02222 426355002986 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 426355002987 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 426355002988 Protein of unknown function (DUF465); Region: DUF465; cl01070 426355002989 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 426355002990 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426355002991 acyl-activating enzyme (AAE) consensus motif; other site 426355002992 AMP binding site [chemical binding]; other site 426355002993 active site 426355002994 CoA binding site [chemical binding]; other site 426355002995 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 426355002996 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 426355002997 active site 426355002998 FMN binding site [chemical binding]; other site 426355002999 substrate binding site [chemical binding]; other site 426355003000 homotetramer interface [polypeptide binding]; other site 426355003001 catalytic residue [active] 426355003002 Predicted periplasmic protein [Function unknown]; Region: COG3698 426355003003 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 426355003004 benzoate transport; Region: 2A0115; TIGR00895 426355003005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355003006 putative substrate translocation pore; other site 426355003007 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 426355003008 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 426355003009 active site 426355003010 metabolite-proton symporter; Region: 2A0106; TIGR00883 426355003011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355003012 putative substrate translocation pore; other site 426355003013 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426355003014 PGAP1-like protein; Region: PGAP1; pfam07819 426355003015 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 426355003016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355003017 non-specific DNA binding site [nucleotide binding]; other site 426355003018 salt bridge; other site 426355003019 sequence-specific DNA binding site [nucleotide binding]; other site 426355003020 Cupin domain; Region: Cupin_2; pfam07883 426355003021 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 426355003022 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426355003023 inhibitor-cofactor binding pocket; inhibition site 426355003024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355003025 catalytic residue [active] 426355003026 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 426355003027 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355003028 NAD(P) binding site [chemical binding]; other site 426355003029 active site 426355003030 acetylornithine deacetylase; Provisional; Region: PRK06837 426355003031 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 426355003032 metal binding site [ion binding]; metal-binding site 426355003033 dimer interface [polypeptide binding]; other site 426355003034 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355003035 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355003036 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 426355003037 putative dimerization interface [polypeptide binding]; other site 426355003038 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 426355003039 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 426355003040 FMN binding site [chemical binding]; other site 426355003041 substrate binding site [chemical binding]; other site 426355003042 putative catalytic residue [active] 426355003043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426355003044 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426355003045 putative glutathione S-transferase; Provisional; Region: PRK10357 426355003046 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 426355003047 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 426355003048 dimer interface [polypeptide binding]; other site 426355003049 N-terminal domain interface [polypeptide binding]; other site 426355003050 putative substrate binding pocket (H-site) [chemical binding]; other site 426355003051 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 426355003052 putative hydrophobic ligand binding site [chemical binding]; other site 426355003053 protein interface [polypeptide binding]; other site 426355003054 gate; other site 426355003055 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355003056 LysR family transcriptional regulator; Provisional; Region: PRK14997 426355003057 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 426355003058 putative effector binding pocket; other site 426355003059 dimerization interface [polypeptide binding]; other site 426355003060 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 426355003061 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 426355003062 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 426355003063 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 426355003064 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 426355003065 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 426355003066 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 426355003067 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 426355003068 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426355003069 molybdopterin cofactor binding site; other site 426355003070 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 426355003071 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 426355003072 molybdopterin cofactor binding site; other site 426355003073 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426355003074 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 426355003075 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 426355003076 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 426355003077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355003078 dimer interface [polypeptide binding]; other site 426355003079 conserved gate region; other site 426355003080 putative PBP binding loops; other site 426355003081 ABC-ATPase subunit interface; other site 426355003082 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 426355003083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355003084 dimer interface [polypeptide binding]; other site 426355003085 conserved gate region; other site 426355003086 putative PBP binding loops; other site 426355003087 ABC-ATPase subunit interface; other site 426355003088 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 426355003089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355003090 Walker A/P-loop; other site 426355003091 ATP binding site [chemical binding]; other site 426355003092 Q-loop/lid; other site 426355003093 ABC transporter signature motif; other site 426355003094 Walker B; other site 426355003095 D-loop; other site 426355003096 H-loop/switch region; other site 426355003097 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 426355003098 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 426355003099 dimer interface [polypeptide binding]; other site 426355003100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355003101 catalytic residue [active] 426355003102 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426355003103 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 426355003104 PhnA protein; Region: PhnA; pfam03831 426355003105 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 426355003106 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 426355003107 putative NAD(P) binding site [chemical binding]; other site 426355003108 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 426355003109 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 426355003110 B12 binding site [chemical binding]; other site 426355003111 cobalt ligand [ion binding]; other site 426355003112 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 426355003113 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 426355003114 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426355003115 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355003116 dimerization interface [polypeptide binding]; other site 426355003117 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355003118 dimer interface [polypeptide binding]; other site 426355003119 putative CheW interface [polypeptide binding]; other site 426355003120 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 426355003121 Mg++ binding site [ion binding]; other site 426355003122 putative catalytic motif [active] 426355003123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355003124 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355003125 NAD(P) binding site [chemical binding]; other site 426355003126 active site 426355003127 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 426355003128 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 426355003129 putative active site; other site 426355003130 catalytic residue [active] 426355003131 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426355003132 catalytic core [active] 426355003133 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426355003134 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 426355003135 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 426355003136 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 426355003137 putative dimer interface [polypeptide binding]; other site 426355003138 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 426355003139 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 426355003140 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 426355003141 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 426355003142 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 426355003143 MG2 domain; Region: A2M_N; pfam01835 426355003144 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 426355003145 surface patch; other site 426355003146 thioester region; other site 426355003147 specificity defining residues; other site 426355003148 Mechanosensitive ion channel; Region: MS_channel; pfam00924 426355003149 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 426355003150 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 426355003151 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355003152 FeS/SAM binding site; other site 426355003153 Methyltransferase domain; Region: Methyltransf_12; pfam08242 426355003154 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 426355003155 putative GSH binding site [chemical binding]; other site 426355003156 catalytic residues [active] 426355003157 Domain of unknown function DUF29; Region: DUF29; pfam01724 426355003158 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 426355003159 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 426355003160 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 426355003161 dimerization interface [polypeptide binding]; other site 426355003162 ATP binding site [chemical binding]; other site 426355003163 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 426355003164 dimerization interface [polypeptide binding]; other site 426355003165 ATP binding site [chemical binding]; other site 426355003166 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 426355003167 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426355003168 ATP binding site [chemical binding]; other site 426355003169 putative Mg++ binding site [ion binding]; other site 426355003170 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426355003171 nucleotide binding region [chemical binding]; other site 426355003172 ATP-binding site [chemical binding]; other site 426355003173 RQC domain; Region: RQC; pfam09382 426355003174 HRDC domain; Region: HRDC; pfam00570 426355003175 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 426355003176 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 426355003177 putative active site [active] 426355003178 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355003179 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 426355003180 putative NAD(P) binding site [chemical binding]; other site 426355003181 active site 426355003182 putative substrate binding site [chemical binding]; other site 426355003183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 426355003184 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 426355003185 fructose-bisphosphate aldolase; Region: PLN02858 426355003186 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 426355003187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355003188 putative substrate translocation pore; other site 426355003189 Transcriptional regulators [Transcription]; Region: PurR; COG1609 426355003190 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 426355003191 DNA binding site [nucleotide binding] 426355003192 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 426355003193 putative ligand binding site [chemical binding]; other site 426355003194 putative dimerization interface [polypeptide binding]; other site 426355003195 putative aldolase; Validated; Region: PRK08130 426355003196 intersubunit interface [polypeptide binding]; other site 426355003197 active site 426355003198 Zn2+ binding site [ion binding]; other site 426355003199 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 426355003200 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 426355003201 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 426355003202 dimer interface [polypeptide binding]; other site 426355003203 motif 1; other site 426355003204 active site 426355003205 motif 2; other site 426355003206 motif 3; other site 426355003207 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 426355003208 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 426355003209 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 426355003210 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 426355003211 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 426355003212 intersubunit interface [polypeptide binding]; other site 426355003213 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 426355003214 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 426355003215 pyridoxamine kinase; Validated; Region: PRK05756 426355003216 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 426355003217 dimer interface [polypeptide binding]; other site 426355003218 pyridoxal binding site [chemical binding]; other site 426355003219 ATP binding site [chemical binding]; other site 426355003220 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 426355003221 NUDIX domain; Region: NUDIX; pfam00293 426355003222 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426355003223 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355003224 substrate binding pocket [chemical binding]; other site 426355003225 membrane-bound complex binding site; other site 426355003226 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 426355003227 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 426355003228 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 426355003229 active site 426355003230 catalytic site [active] 426355003231 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 426355003232 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 426355003233 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 426355003234 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 426355003235 Uncharacterized conserved protein [Function unknown]; Region: COG4104 426355003236 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 426355003237 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 426355003238 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 426355003239 Competence protein J (ComJ); Region: ComJ; pfam11033 426355003240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 426355003241 Integrase core domain; Region: rve; pfam00665 426355003242 Integrase core domain; Region: rve_3; pfam13683 426355003243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426355003244 Methyltransferase domain; Region: Methyltransf_31; pfam13847 426355003245 Alpha 1,4-glycosyltransferase conserved region; Region: Gb3_synth; pfam04572 426355003246 Cytochrome c2 [Energy production and conversion]; Region: COG3474 426355003247 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 426355003248 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 426355003249 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 426355003250 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 426355003251 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 426355003252 23S rRNA interface [nucleotide binding]; other site 426355003253 L3 interface [polypeptide binding]; other site 426355003254 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 426355003255 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 426355003256 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 426355003257 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 426355003258 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 426355003259 active site 426355003260 catalytic triad [active] 426355003261 oxyanion hole [active] 426355003262 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426355003263 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355003264 active site 426355003265 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426355003266 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 426355003267 active site 426355003268 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 426355003269 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 426355003270 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355003271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355003272 NAD(P) binding site [chemical binding]; other site 426355003273 active site 426355003274 Protein of unknown function (DUF563); Region: DUF563; pfam04577 426355003275 WxcM-like, C-terminal; Region: FdtA; pfam05523 426355003276 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 426355003277 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 426355003278 inhibitor-cofactor binding pocket; inhibition site 426355003279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355003280 catalytic residue [active] 426355003281 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 426355003282 Protein of unknown function (DUF563); Region: DUF563; pfam04577 426355003283 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 426355003284 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 426355003285 inhibitor-cofactor binding pocket; inhibition site 426355003286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355003287 catalytic residue [active] 426355003288 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 426355003289 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 426355003290 putative trimer interface [polypeptide binding]; other site 426355003291 putative CoA binding site [chemical binding]; other site 426355003292 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 426355003293 classical (c) SDRs; Region: SDR_c; cd05233 426355003294 NAD(P) binding site [chemical binding]; other site 426355003295 active site 426355003296 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12880 426355003297 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 426355003298 dimer interface [polypeptide binding]; other site 426355003299 active site 426355003300 CoA binding pocket [chemical binding]; other site 426355003301 FkbH-like domain; Region: FkbH; TIGR01686 426355003302 Acid Phosphatase; Region: Acid_PPase; cl17256 426355003303 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 426355003304 active site 426355003305 catalytic site [active] 426355003306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355003307 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 426355003308 trimer interface [polypeptide binding]; other site 426355003309 active site 426355003310 substrate binding site [chemical binding]; other site 426355003311 CoA binding site [chemical binding]; other site 426355003312 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 426355003313 active site 426355003314 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355003315 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426355003316 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 426355003317 ABC-2 type transporter; Region: ABC2_membrane; cl17235 426355003318 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 426355003319 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 426355003320 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 426355003321 Probable Catalytic site; other site 426355003322 metal-binding site 426355003323 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 426355003324 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 426355003325 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426355003326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355003327 S-adenosylmethionine binding site [chemical binding]; other site 426355003328 active site 426355003329 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 426355003330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 426355003331 Methyltransferase domain; Region: Methyltransf_24; pfam13578 426355003332 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355003333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355003334 NAD(P) binding site [chemical binding]; other site 426355003335 active site 426355003336 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 426355003337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355003338 active site 426355003339 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 426355003340 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426355003341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355003342 S-adenosylmethionine binding site [chemical binding]; other site 426355003343 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 426355003344 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 426355003345 dimer interface [polypeptide binding]; other site 426355003346 ADP-ribose binding site [chemical binding]; other site 426355003347 active site 426355003348 nudix motif; other site 426355003349 metal binding site [ion binding]; metal-binding site 426355003350 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 426355003351 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 426355003352 Substrate binding site; other site 426355003353 Mg++ binding site; other site 426355003354 metal-binding site 426355003355 Mg++ binding site; other site 426355003356 metal-binding site 426355003357 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 426355003358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426355003359 active site 426355003360 motif I; other site 426355003361 motif II; other site 426355003362 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 426355003363 dimer interface [polypeptide binding]; other site 426355003364 active site 426355003365 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355003366 extended (e) SDRs; Region: SDR_e; cd08946 426355003367 NAD(P) binding site [chemical binding]; other site 426355003368 active site 426355003369 substrate binding site [chemical binding]; other site 426355003370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355003371 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 426355003372 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 426355003373 active site 426355003374 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 426355003375 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 426355003376 active site 426355003377 substrate binding site [chemical binding]; other site 426355003378 metal binding site [ion binding]; metal-binding site 426355003379 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 426355003380 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426355003381 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355003382 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 426355003383 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355003384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355003385 active site 426355003386 phosphorylation site [posttranslational modification] 426355003387 intermolecular recognition site; other site 426355003388 dimerization interface [polypeptide binding]; other site 426355003389 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355003390 DNA binding site [nucleotide binding] 426355003391 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 426355003392 dimerization interface [polypeptide binding]; other site 426355003393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355003394 ATP binding site [chemical binding]; other site 426355003395 Mg2+ binding site [ion binding]; other site 426355003396 G-X-G motif; other site 426355003397 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355003398 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355003399 metal binding site [ion binding]; metal-binding site 426355003400 active site 426355003401 I-site; other site 426355003402 PilZ domain; Region: PilZ; pfam07238 426355003403 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426355003404 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355003405 DNA-binding site [nucleotide binding]; DNA binding site 426355003406 FCD domain; Region: FCD; pfam07729 426355003407 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 426355003408 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 426355003409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355003410 Walker A/P-loop; other site 426355003411 ATP binding site [chemical binding]; other site 426355003412 Q-loop/lid; other site 426355003413 ABC transporter signature motif; other site 426355003414 Walker B; other site 426355003415 D-loop; other site 426355003416 H-loop/switch region; other site 426355003417 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 426355003418 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 426355003419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 426355003420 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 426355003421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355003422 ABC-ATPase subunit interface; other site 426355003423 putative PBP binding loops; other site 426355003424 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 426355003425 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 426355003426 Amidase; Region: Amidase; cl11426 426355003427 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 426355003428 active site 426355003429 homotetramer interface [polypeptide binding]; other site 426355003430 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426355003431 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 426355003432 active site 426355003433 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 426355003434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355003435 NAD(P) binding site [chemical binding]; other site 426355003436 active site 426355003437 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 426355003438 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 426355003439 substrate binding site; other site 426355003440 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355003441 extended (e) SDRs; Region: SDR_e; cd08946 426355003442 NAD(P) binding site [chemical binding]; other site 426355003443 active site 426355003444 substrate binding site [chemical binding]; other site 426355003445 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 426355003446 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 426355003447 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 426355003448 inhibitor-cofactor binding pocket; inhibition site 426355003449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355003450 catalytic residue [active] 426355003451 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355003452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 426355003453 dimer interface [polypeptide binding]; other site 426355003454 phosphorylation site [posttranslational modification] 426355003455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355003456 ATP binding site [chemical binding]; other site 426355003457 Mg2+ binding site [ion binding]; other site 426355003458 G-X-G motif; other site 426355003459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355003460 active site 426355003461 phosphorylation site [posttranslational modification] 426355003462 intermolecular recognition site; other site 426355003463 dimerization interface [polypeptide binding]; other site 426355003464 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 426355003465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355003466 active site 426355003467 phosphorylation site [posttranslational modification] 426355003468 intermolecular recognition site; other site 426355003469 dimerization interface [polypeptide binding]; other site 426355003470 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355003471 dimerization interface [polypeptide binding]; other site 426355003472 DNA binding residues [nucleotide binding] 426355003473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355003474 metabolite-proton symporter; Region: 2A0106; TIGR00883 426355003475 putative substrate translocation pore; other site 426355003476 PAS domain S-box; Region: sensory_box; TIGR00229 426355003477 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355003478 putative active site [active] 426355003479 heme pocket [chemical binding]; other site 426355003480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355003481 ATP binding site [chemical binding]; other site 426355003482 Mg2+ binding site [ion binding]; other site 426355003483 G-X-G motif; other site 426355003484 mercuric reductase; Validated; Region: PRK06370 426355003485 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426355003486 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 426355003487 Predicted membrane protein [Function unknown]; Region: COG3059 426355003488 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 426355003489 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355003490 catalytic loop [active] 426355003491 iron binding site [ion binding]; other site 426355003492 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426355003493 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426355003494 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355003495 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426355003496 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355003497 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355003498 PAS domain; Region: PAS_9; pfam13426 426355003499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355003500 ATP binding site [chemical binding]; other site 426355003501 Mg2+ binding site [ion binding]; other site 426355003502 G-X-G motif; other site 426355003503 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 426355003504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355003505 NAD(P) binding site [chemical binding]; other site 426355003506 active site 426355003507 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 426355003508 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 426355003509 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 426355003510 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 426355003511 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426355003512 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355003513 DNA binding residues [nucleotide binding] 426355003514 dimerization interface [polypeptide binding]; other site 426355003515 Protein of unknown function, DUF606; Region: DUF606; pfam04657 426355003516 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426355003517 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355003518 substrate binding pocket [chemical binding]; other site 426355003519 membrane-bound complex binding site; other site 426355003520 hinge residues; other site 426355003521 Acyltransferase family; Region: Acyl_transf_3; pfam01757 426355003522 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 426355003523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 426355003524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355003525 HWE histidine kinase; Region: HWE_HK; pfam07536 426355003526 muropeptide transporter; Validated; Region: ampG; cl17669 426355003527 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 426355003528 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 426355003529 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426355003530 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 426355003531 Walker A/P-loop; other site 426355003532 ATP binding site [chemical binding]; other site 426355003533 Q-loop/lid; other site 426355003534 ABC transporter signature motif; other site 426355003535 Walker B; other site 426355003536 D-loop; other site 426355003537 H-loop/switch region; other site 426355003538 Transcriptional regulators [Transcription]; Region: PurR; COG1609 426355003539 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 426355003540 DNA binding site [nucleotide binding] 426355003541 domain linker motif; other site 426355003542 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 426355003543 dimerization interface [polypeptide binding]; other site 426355003544 ligand binding site [chemical binding]; other site 426355003545 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 426355003546 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 426355003547 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426355003548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355003549 S-adenosylmethionine binding site [chemical binding]; other site 426355003550 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426355003551 catalytic core [active] 426355003552 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 426355003553 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 426355003554 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 426355003555 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355003556 NAD binding site [chemical binding]; other site 426355003557 putative substrate binding site 2 [chemical binding]; other site 426355003558 putative substrate binding site 1 [chemical binding]; other site 426355003559 active site 426355003560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 426355003561 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426355003562 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 426355003563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 426355003564 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 426355003565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 426355003566 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 426355003567 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426355003568 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355003569 B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295 426355003570 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 426355003571 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355003572 FeS/SAM binding site; other site 426355003573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355003574 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355003575 NAD(P) binding site [chemical binding]; other site 426355003576 active site 426355003577 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355003578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355003579 NAD(P) binding site [chemical binding]; other site 426355003580 active site 426355003581 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 426355003582 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 426355003583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355003584 putative substrate translocation pore; other site 426355003585 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 426355003586 active site 426355003587 catalytic residues [active] 426355003588 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 426355003589 Transcriptional regulators [Transcription]; Region: FadR; COG2186 426355003590 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355003591 DNA-binding site [nucleotide binding]; DNA binding site 426355003592 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 426355003593 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 426355003594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 426355003595 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 426355003596 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 426355003597 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 426355003598 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 426355003599 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 426355003600 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426355003601 Walker A motif; other site 426355003602 ATP binding site [chemical binding]; other site 426355003603 Walker B motif; other site 426355003604 KaiC; Region: KaiC; pfam06745 426355003605 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426355003606 Walker A motif; other site 426355003607 ATP binding site [chemical binding]; other site 426355003608 Walker B motif; other site 426355003609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355003610 HWE histidine kinase; Region: HWE_HK; pfam07536 426355003611 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 426355003612 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 426355003613 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426355003614 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355003615 substrate binding pocket [chemical binding]; other site 426355003616 membrane-bound complex binding site; other site 426355003617 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426355003618 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355003619 substrate binding pocket [chemical binding]; other site 426355003620 membrane-bound complex binding site; other site 426355003621 hinge residues; other site 426355003622 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426355003623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355003624 dimer interface [polypeptide binding]; other site 426355003625 conserved gate region; other site 426355003626 putative PBP binding loops; other site 426355003627 ABC-ATPase subunit interface; other site 426355003628 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 426355003629 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426355003630 Walker A/P-loop; other site 426355003631 ATP binding site [chemical binding]; other site 426355003632 Q-loop/lid; other site 426355003633 ABC transporter signature motif; other site 426355003634 Walker B; other site 426355003635 D-loop; other site 426355003636 H-loop/switch region; other site 426355003637 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 426355003638 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 426355003639 active site 426355003640 dimer interface [polypeptide binding]; other site 426355003641 non-prolyl cis peptide bond; other site 426355003642 insertion regions; other site 426355003643 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 426355003644 Sulfate transporter family; Region: Sulfate_transp; pfam00916 426355003645 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 426355003646 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355003647 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355003648 ligand binding site [chemical binding]; other site 426355003649 flexible hinge region; other site 426355003650 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 426355003651 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 426355003652 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 426355003653 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426355003654 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 426355003655 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 426355003656 MbtH-like protein; Region: MbtH; cl01279 426355003657 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 426355003658 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 426355003659 acyl-activating enzyme (AAE) consensus motif; other site 426355003660 AMP binding site [chemical binding]; other site 426355003661 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 426355003662 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 426355003663 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426355003664 Coenzyme A binding pocket [chemical binding]; other site 426355003665 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 426355003666 oxyanion hole [active] 426355003667 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 426355003668 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 426355003669 NAD binding site [chemical binding]; other site 426355003670 homodimer interface [polypeptide binding]; other site 426355003671 homotetramer interface [polypeptide binding]; other site 426355003672 active site 426355003673 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 426355003674 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426355003675 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426355003676 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355003677 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426355003678 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426355003679 active site 426355003680 catalytic tetrad [active] 426355003681 AIR carboxylase; Region: AIRC; cl00310 426355003682 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 426355003683 Protein of unknown function DUF111; Region: DUF111; cl03398 426355003684 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355003685 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355003686 ligand binding site [chemical binding]; other site 426355003687 flexible hinge region; other site 426355003688 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426355003689 putative switch regulator; other site 426355003690 non-specific DNA interactions [nucleotide binding]; other site 426355003691 DNA binding site [nucleotide binding] 426355003692 sequence specific DNA binding site [nucleotide binding]; other site 426355003693 putative cAMP binding site [chemical binding]; other site 426355003694 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 426355003695 short chain dehydrogenase; Provisional; Region: PRK07109 426355003696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355003697 NAD(P) binding site [chemical binding]; other site 426355003698 active site 426355003699 RNA polymerase sigma factor; Provisional; Region: PRK12547 426355003700 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355003701 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426355003702 DNA binding residues [nucleotide binding] 426355003703 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 426355003704 active site 426355003705 metal binding site [ion binding]; metal-binding site 426355003706 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 426355003707 helix-hairpin-helix signature motif; other site 426355003708 Predicted transcriptional regulators [Transcription]; Region: COG1733 426355003709 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 426355003710 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 426355003711 Hemerythrin-like domain; Region: Hr-like; cd12108 426355003712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426355003713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355003714 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 426355003715 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426355003716 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355003717 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355003718 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 426355003719 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 426355003720 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 426355003721 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426355003722 putative DNA binding site [nucleotide binding]; other site 426355003723 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 426355003724 ArsC family; Region: ArsC; pfam03960 426355003725 catalytic residues [active] 426355003726 arsenical pump membrane protein; Provisional; Region: PRK15445 426355003727 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 426355003728 transmembrane helices; other site 426355003729 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 426355003730 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426355003731 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 426355003732 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426355003733 cyclase homology domain; Region: CHD; cd07302 426355003734 nucleotidyl binding site; other site 426355003735 metal binding site [ion binding]; metal-binding site 426355003736 dimer interface [polypeptide binding]; other site 426355003737 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 426355003738 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 426355003739 putative active site [active] 426355003740 putative NTP binding site [chemical binding]; other site 426355003741 putative nucleic acid binding site [nucleotide binding]; other site 426355003742 WGR domain of bacterial DNA ligases; Region: WGR_DNA_ligase; cd07998 426355003743 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 426355003744 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 426355003745 metal ion-dependent adhesion site (MIDAS); other site 426355003746 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 426355003747 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 426355003748 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 426355003749 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 426355003750 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 426355003751 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 426355003752 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 426355003753 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355003754 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 426355003755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355003756 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 426355003757 short chain dehydrogenase; Provisional; Region: PRK07109 426355003758 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 426355003759 putative NAD(P) binding site [chemical binding]; other site 426355003760 active site 426355003761 RNA polymerase sigma factor; Provisional; Region: PRK11924 426355003762 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355003763 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426355003764 DNA binding residues [nucleotide binding] 426355003765 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 426355003766 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 426355003767 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 426355003768 putative NAD(P) binding site [chemical binding]; other site 426355003769 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 426355003770 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 426355003771 ligand binding site [chemical binding]; other site 426355003772 NAD binding site [chemical binding]; other site 426355003773 tetramer interface [polypeptide binding]; other site 426355003774 catalytic site [active] 426355003775 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 426355003776 L-serine binding site [chemical binding]; other site 426355003777 ACT domain interface; other site 426355003778 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 426355003779 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 426355003780 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426355003781 catalytic residue [active] 426355003782 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355003783 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355003784 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 426355003785 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 426355003786 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 426355003787 trimer interface [polypeptide binding]; other site 426355003788 active site 426355003789 substrate binding site [chemical binding]; other site 426355003790 CoA binding site [chemical binding]; other site 426355003791 Predicted periplasmic protein [Function unknown]; Region: COG3904 426355003792 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426355003793 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426355003794 Walker A/P-loop; other site 426355003795 ATP binding site [chemical binding]; other site 426355003796 Q-loop/lid; other site 426355003797 ABC transporter signature motif; other site 426355003798 Walker B; other site 426355003799 D-loop; other site 426355003800 H-loop/switch region; other site 426355003801 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 426355003802 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355003803 putative ligand binding site [chemical binding]; other site 426355003804 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426355003805 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426355003806 TM-ABC transporter signature motif; other site 426355003807 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426355003808 TM-ABC transporter signature motif; other site 426355003809 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426355003810 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426355003811 Walker A/P-loop; other site 426355003812 ATP binding site [chemical binding]; other site 426355003813 Q-loop/lid; other site 426355003814 ABC transporter signature motif; other site 426355003815 Walker B; other site 426355003816 D-loop; other site 426355003817 H-loop/switch region; other site 426355003818 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355003819 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355003820 ligand binding site [chemical binding]; other site 426355003821 flexible hinge region; other site 426355003822 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 426355003823 putative switch regulator; other site 426355003824 non-specific DNA interactions [nucleotide binding]; other site 426355003825 DNA binding site [nucleotide binding] 426355003826 sequence specific DNA binding site [nucleotide binding]; other site 426355003827 putative cAMP binding site [chemical binding]; other site 426355003828 hypothetical protein; Provisional; Region: PRK13559 426355003829 HWE histidine kinase; Region: HWE_HK; smart00911 426355003830 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355003831 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355003832 ligand binding site [chemical binding]; other site 426355003833 flexible hinge region; other site 426355003834 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426355003835 non-specific DNA interactions [nucleotide binding]; other site 426355003836 DNA binding site [nucleotide binding] 426355003837 sequence specific DNA binding site [nucleotide binding]; other site 426355003838 putative cAMP binding site [chemical binding]; other site 426355003839 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355003840 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 426355003841 putative ligand binding site [chemical binding]; other site 426355003842 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426355003843 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426355003844 TM-ABC transporter signature motif; other site 426355003845 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426355003846 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426355003847 TM-ABC transporter signature motif; other site 426355003848 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 426355003849 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426355003850 Walker A/P-loop; other site 426355003851 ATP binding site [chemical binding]; other site 426355003852 Q-loop/lid; other site 426355003853 ABC transporter signature motif; other site 426355003854 Walker B; other site 426355003855 D-loop; other site 426355003856 H-loop/switch region; other site 426355003857 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 426355003858 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426355003859 Walker A/P-loop; other site 426355003860 ATP binding site [chemical binding]; other site 426355003861 Q-loop/lid; other site 426355003862 ABC transporter signature motif; other site 426355003863 Walker B; other site 426355003864 D-loop; other site 426355003865 H-loop/switch region; other site 426355003866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355003867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355003868 dimer interface [polypeptide binding]; other site 426355003869 phosphorylation site [posttranslational modification] 426355003870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355003871 ATP binding site [chemical binding]; other site 426355003872 Mg2+ binding site [ion binding]; other site 426355003873 G-X-G motif; other site 426355003874 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355003875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355003876 active site 426355003877 phosphorylation site [posttranslational modification] 426355003878 intermolecular recognition site; other site 426355003879 dimerization interface [polypeptide binding]; other site 426355003880 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426355003881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355003882 active site 426355003883 phosphorylation site [posttranslational modification] 426355003884 intermolecular recognition site; other site 426355003885 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355003886 DNA binding residues [nucleotide binding] 426355003887 stage V sporulation protein K; Region: spore_V_K; TIGR02881 426355003888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355003889 Walker A motif; other site 426355003890 ATP binding site [chemical binding]; other site 426355003891 Walker B motif; other site 426355003892 arginine finger; other site 426355003893 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426355003894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355003895 Walker A motif; other site 426355003896 ATP binding site [chemical binding]; other site 426355003897 Walker B motif; other site 426355003898 arginine finger; other site 426355003899 stage V sporulation protein K; Region: spore_V_K; TIGR02881 426355003900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355003901 Walker A motif; other site 426355003902 ATP binding site [chemical binding]; other site 426355003903 Walker B motif; other site 426355003904 arginine finger; other site 426355003905 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 426355003906 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426355003907 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 426355003908 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 426355003909 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 426355003910 FAD binding domain; Region: FAD_binding_4; pfam01565 426355003911 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 426355003912 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 426355003913 homotrimer interface [polypeptide binding]; other site 426355003914 Walker A motif; other site 426355003915 GTP binding site [chemical binding]; other site 426355003916 Walker B motif; other site 426355003917 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 426355003918 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 426355003919 cobyric acid synthase; Provisional; Region: PRK00784 426355003920 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426355003921 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426355003922 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 426355003923 catalytic triad [active] 426355003924 D-galactonate transporter; Region: 2A0114; TIGR00893 426355003925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355003926 putative substrate translocation pore; other site 426355003927 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 426355003928 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 426355003929 NAD binding site [chemical binding]; other site 426355003930 CobD/Cbib protein; Region: CobD_Cbib; cl00561 426355003931 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 426355003932 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426355003933 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 426355003934 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426355003935 catalytic residue [active] 426355003936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355003937 putative substrate translocation pore; other site 426355003938 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 426355003939 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 426355003940 malonyl-CoA synthase; Validated; Region: PRK07514 426355003941 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426355003942 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 426355003943 acyl-activating enzyme (AAE) consensus motif; other site 426355003944 active site 426355003945 AMP binding site [chemical binding]; other site 426355003946 CoA binding site [chemical binding]; other site 426355003947 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 426355003948 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 426355003949 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 426355003950 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 426355003951 active site 426355003952 homotetramer interface [polypeptide binding]; other site 426355003953 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 426355003954 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 426355003955 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 426355003956 active site 426355003957 catalytic site [active] 426355003958 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 426355003959 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 426355003960 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426355003961 active site 426355003962 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 426355003963 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 426355003964 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355003965 dimerization interface [polypeptide binding]; other site 426355003966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 426355003967 putative active site [active] 426355003968 heme pocket [chemical binding]; other site 426355003969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355003970 dimer interface [polypeptide binding]; other site 426355003971 phosphorylation site [posttranslational modification] 426355003972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355003973 ATP binding site [chemical binding]; other site 426355003974 Mg2+ binding site [ion binding]; other site 426355003975 G-X-G motif; other site 426355003976 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 426355003977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355003978 active site 426355003979 phosphorylation site [posttranslational modification] 426355003980 intermolecular recognition site; other site 426355003981 dimerization interface [polypeptide binding]; other site 426355003982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355003983 Walker A motif; other site 426355003984 ATP binding site [chemical binding]; other site 426355003985 Walker B motif; other site 426355003986 arginine finger; other site 426355003987 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 426355003988 bacterial Hfq-like; Region: Hfq; cd01716 426355003989 hexamer interface [polypeptide binding]; other site 426355003990 Sm1 motif; other site 426355003991 RNA binding site [nucleotide binding]; other site 426355003992 Sm2 motif; other site 426355003993 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 426355003994 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 426355003995 HflX GTPase family; Region: HflX; cd01878 426355003996 G1 box; other site 426355003997 GTP/Mg2+ binding site [chemical binding]; other site 426355003998 Switch I region; other site 426355003999 G2 box; other site 426355004000 G3 box; other site 426355004001 Switch II region; other site 426355004002 G4 box; other site 426355004003 G5 box; other site 426355004004 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426355004005 cyclase homology domain; Region: CHD; cd07302 426355004006 nucleotidyl binding site; other site 426355004007 metal binding site [ion binding]; metal-binding site 426355004008 dimer interface [polypeptide binding]; other site 426355004009 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 426355004010 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 426355004011 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355004012 Walker A/P-loop; other site 426355004013 ATP binding site [chemical binding]; other site 426355004014 Q-loop/lid; other site 426355004015 ABC transporter signature motif; other site 426355004016 Walker B; other site 426355004017 D-loop; other site 426355004018 H-loop/switch region; other site 426355004019 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 426355004020 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 426355004021 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 426355004022 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426355004023 N-terminal plug; other site 426355004024 ligand-binding site [chemical binding]; other site 426355004025 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-2; cd12809 426355004026 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426355004027 catalytic site [active] 426355004028 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 426355004029 acyl-CoA synthetase; Validated; Region: PRK08162 426355004030 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 426355004031 acyl-activating enzyme (AAE) consensus motif; other site 426355004032 putative active site [active] 426355004033 AMP binding site [chemical binding]; other site 426355004034 putative CoA binding site [chemical binding]; other site 426355004035 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 426355004036 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426355004037 P-loop; other site 426355004038 Magnesium ion binding site [ion binding]; other site 426355004039 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 426355004040 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 426355004041 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 426355004042 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 426355004043 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 426355004044 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 426355004045 thymidylate kinase; Validated; Region: tmk; PRK00698 426355004046 TMP-binding site; other site 426355004047 ATP-binding site [chemical binding]; other site 426355004048 DNA polymerase III subunit delta'; Validated; Region: PRK07471 426355004049 DNA polymerase III subunit delta'; Validated; Region: PRK08485 426355004050 MarR family; Region: MarR_2; pfam12802 426355004051 hypothetical protein; Provisional; Region: PRK06184 426355004052 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426355004053 hypothetical protein; Provisional; Region: PRK07236 426355004054 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 426355004055 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 426355004056 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 426355004057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355004058 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 426355004059 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 426355004060 active site 426355004061 HIGH motif; other site 426355004062 KMSKS motif; other site 426355004063 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 426355004064 tRNA binding surface [nucleotide binding]; other site 426355004065 anticodon binding site; other site 426355004066 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 426355004067 active site 426355004068 putative hydrolase; Provisional; Region: PRK02113 426355004069 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 426355004070 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355004071 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 426355004072 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426355004073 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426355004074 protein binding site [polypeptide binding]; other site 426355004075 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426355004076 protein binding site [polypeptide binding]; other site 426355004077 recombination factor protein RarA; Reviewed; Region: PRK13342 426355004078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355004079 Walker A motif; other site 426355004080 ATP binding site [chemical binding]; other site 426355004081 Walker B motif; other site 426355004082 arginine finger; other site 426355004083 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 426355004084 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 426355004085 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426355004086 putative DNA binding site [nucleotide binding]; other site 426355004087 putative Zn2+ binding site [ion binding]; other site 426355004088 AsnC family; Region: AsnC_trans_reg; pfam01037 426355004089 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 426355004090 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 426355004091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355004092 catalytic residue [active] 426355004093 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 426355004094 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 426355004095 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 426355004096 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 426355004097 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 426355004098 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 426355004099 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 426355004100 Cupin; Region: Cupin_1; smart00835 426355004101 Cupin; Region: Cupin_1; smart00835 426355004102 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426355004103 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355004104 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 426355004105 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 426355004106 Trp docking motif [polypeptide binding]; other site 426355004107 putative active site [active] 426355004108 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 426355004109 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 426355004110 inhibitor site; inhibition site 426355004111 active site 426355004112 dimer interface [polypeptide binding]; other site 426355004113 catalytic residue [active] 426355004114 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426355004115 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426355004116 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355004117 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 426355004118 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 426355004119 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 426355004120 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426355004121 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 426355004122 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426355004123 GAF domain; Region: GAF; pfam01590 426355004124 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355004125 Histidine kinase; Region: HisKA_2; pfam07568 426355004126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355004127 ATP binding site [chemical binding]; other site 426355004128 Mg2+ binding site [ion binding]; other site 426355004129 G-X-G motif; other site 426355004130 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 426355004131 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426355004132 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 426355004133 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426355004134 ATP binding site [chemical binding]; other site 426355004135 putative Mg++ binding site [ion binding]; other site 426355004136 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426355004137 nucleotide binding region [chemical binding]; other site 426355004138 ATP-binding site [chemical binding]; other site 426355004139 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 426355004140 active site 426355004141 SAM binding site [chemical binding]; other site 426355004142 homodimer interface [polypeptide binding]; other site 426355004143 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 426355004144 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 426355004145 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 426355004146 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 426355004147 dimer interface [polypeptide binding]; other site 426355004148 active site 426355004149 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426355004150 substrate binding site [chemical binding]; other site 426355004151 catalytic residue [active] 426355004152 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 426355004153 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 426355004154 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426355004155 catalytic residue [active] 426355004156 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 426355004157 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426355004158 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426355004159 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426355004160 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 426355004161 putative C-terminal domain interface [polypeptide binding]; other site 426355004162 putative GSH binding site (G-site) [chemical binding]; other site 426355004163 putative dimer interface [polypeptide binding]; other site 426355004164 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 426355004165 dimer interface [polypeptide binding]; other site 426355004166 N-terminal domain interface [polypeptide binding]; other site 426355004167 putative substrate binding pocket (H-site) [chemical binding]; other site 426355004168 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355004169 acetylornithine deacetylase; Provisional; Region: PRK07522 426355004170 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 426355004171 metal binding site [ion binding]; metal-binding site 426355004172 putative dimer interface [polypeptide binding]; other site 426355004173 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 426355004174 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355004175 HWE histidine kinase; Region: HWE_HK; pfam07536 426355004176 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 426355004177 active site clefts [active] 426355004178 zinc binding site [ion binding]; other site 426355004179 dimer interface [polypeptide binding]; other site 426355004180 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 426355004181 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 426355004182 Sulfate transporter family; Region: Sulfate_transp; pfam00916 426355004183 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 426355004184 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 426355004185 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 426355004186 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 426355004187 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 426355004188 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 426355004189 benzoate transport; Region: 2A0115; TIGR00895 426355004190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355004191 putative substrate translocation pore; other site 426355004192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355004193 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426355004194 Nitrate and nitrite sensing; Region: NIT; pfam08376 426355004195 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355004196 dimer interface [polypeptide binding]; other site 426355004197 putative CheW interface [polypeptide binding]; other site 426355004198 Predicted transcriptional regulators [Transcription]; Region: COG1733 426355004199 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 426355004200 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 426355004201 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 426355004202 putative NAD(P) binding site [chemical binding]; other site 426355004203 dimer interface [polypeptide binding]; other site 426355004204 Cupin domain; Region: Cupin_2; cl17218 426355004205 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 426355004206 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 426355004207 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 426355004208 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 426355004209 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 426355004210 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 426355004211 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426355004212 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426355004213 protein binding site [polypeptide binding]; other site 426355004214 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 426355004215 Glucose inhibited division protein A; Region: GIDA; pfam01134 426355004216 allantoate amidohydrolase; Reviewed; Region: PRK12892 426355004217 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 426355004218 active site 426355004219 metal binding site [ion binding]; metal-binding site 426355004220 dimer interface [polypeptide binding]; other site 426355004221 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 426355004222 trimer interface [polypeptide binding]; other site 426355004223 active site 426355004224 substrate binding site [chemical binding]; other site 426355004225 CoA binding site [chemical binding]; other site 426355004226 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 426355004227 active site 426355004228 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355004229 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355004230 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426355004231 Predicted transcriptional regulators [Transcription]; Region: COG1695 426355004232 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 426355004233 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355004234 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 426355004235 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 426355004236 Probable Catalytic site; other site 426355004237 metal-binding site 426355004238 pyrimidine utilization protein D; Region: RutD; TIGR03611 426355004239 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426355004240 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 426355004241 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 426355004242 homotrimer interaction site [polypeptide binding]; other site 426355004243 putative active site [active] 426355004244 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 426355004245 catalytic triad [active] 426355004246 Isochorismatase family; Region: Isochorismatase; pfam00857 426355004247 conserved cis-peptide bond; other site 426355004248 pyrimidine utilization protein A; Region: RutA; TIGR03612 426355004249 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 426355004250 active site 426355004251 dimer interface [polypeptide binding]; other site 426355004252 non-prolyl cis peptide bond; other site 426355004253 insertion regions; other site 426355004254 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 426355004255 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 426355004256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355004257 catalytic residue [active] 426355004258 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 426355004259 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 426355004260 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 426355004261 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 426355004262 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355004263 PAS fold; Region: PAS_3; pfam08447 426355004264 putative active site [active] 426355004265 heme pocket [chemical binding]; other site 426355004266 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355004267 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355004268 metal binding site [ion binding]; metal-binding site 426355004269 active site 426355004270 I-site; other site 426355004271 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355004272 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 426355004273 FAD binding pocket [chemical binding]; other site 426355004274 conserved FAD binding motif [chemical binding]; other site 426355004275 phosphate binding motif [ion binding]; other site 426355004276 beta-alpha-beta structure motif; other site 426355004277 NAD binding pocket [chemical binding]; other site 426355004278 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 426355004279 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 426355004280 homodimer interface [polypeptide binding]; other site 426355004281 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 426355004282 active site pocket [active] 426355004283 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 426355004284 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 426355004285 active site 426355004286 catalytic site [active] 426355004287 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 426355004288 glycogen synthase; Provisional; Region: glgA; PRK00654 426355004289 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 426355004290 ADP-binding pocket [chemical binding]; other site 426355004291 homodimer interface [polypeptide binding]; other site 426355004292 glycogen branching enzyme; Provisional; Region: PRK05402 426355004293 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 426355004294 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 426355004295 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 426355004296 active site 426355004297 catalytic site [active] 426355004298 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 426355004299 trehalose synthase; Region: treS_nterm; TIGR02456 426355004300 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 426355004301 active site 426355004302 catalytic site [active] 426355004303 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 426355004304 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 426355004305 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 426355004306 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 426355004307 active site 426355004308 catalytic site [active] 426355004309 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 426355004310 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 426355004311 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 426355004312 active site 426355004313 homodimer interface [polypeptide binding]; other site 426355004314 catalytic site [active] 426355004315 acceptor binding site [chemical binding]; other site 426355004316 putative bifunctional 4-alpha-glucanotransferase/malto-oligosyltrehalose synthase; Provisional; Region: PRK14507 426355004317 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 426355004318 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 426355004319 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 426355004320 active site 426355004321 catalytic site [active] 426355004322 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 426355004323 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 426355004324 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 426355004325 catalytic site [active] 426355004326 active site 426355004327 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 426355004328 yiaA/B two helix domain; Region: YiaAB; cl01759 426355004329 WHG domain; Region: WHG; pfam13305 426355004330 NMT1-like family; Region: NMT1_2; pfam13379 426355004331 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426355004332 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 426355004333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355004334 putative substrate translocation pore; other site 426355004335 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 426355004336 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355004337 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355004338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426355004339 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355004340 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 426355004341 benzoate transport; Region: 2A0115; TIGR00895 426355004342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355004343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355004344 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 426355004345 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 426355004346 active site 426355004347 Zn binding site [ion binding]; other site 426355004348 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 426355004349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355004350 active site 426355004351 phosphorylation site [posttranslational modification] 426355004352 intermolecular recognition site; other site 426355004353 dimerization interface [polypeptide binding]; other site 426355004354 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426355004355 Zn2+ binding site [ion binding]; other site 426355004356 Mg2+ binding site [ion binding]; other site 426355004357 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355004358 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355004359 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 426355004360 putative dimerization interface [polypeptide binding]; other site 426355004361 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 426355004362 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 426355004363 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426355004364 PYR/PP interface [polypeptide binding]; other site 426355004365 dimer interface [polypeptide binding]; other site 426355004366 TPP binding site [chemical binding]; other site 426355004367 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426355004368 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 426355004369 TPP-binding site [chemical binding]; other site 426355004370 dimer interface [polypeptide binding]; other site 426355004371 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 426355004372 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 426355004373 manganese transport regulator MntR; Provisional; Region: PRK11050 426355004374 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 426355004375 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 426355004376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 426355004377 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 426355004378 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 426355004379 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 426355004380 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 426355004381 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 426355004382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 426355004383 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 426355004384 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 426355004385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 426355004386 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 426355004387 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 426355004388 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 426355004389 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 426355004390 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 426355004391 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 426355004392 active site 426355004393 nucleotide binding site [chemical binding]; other site 426355004394 HIGH motif; other site 426355004395 KMSKS motif; other site 426355004396 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426355004397 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355004398 substrate binding pocket [chemical binding]; other site 426355004399 membrane-bound complex binding site; other site 426355004400 hinge residues; other site 426355004401 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355004402 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 426355004403 active site 426355004404 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 426355004405 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 426355004406 homodimer interface [polypeptide binding]; other site 426355004407 metal binding site [ion binding]; metal-binding site 426355004408 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 426355004409 homodimer interface [polypeptide binding]; other site 426355004410 active site 426355004411 putative chemical substrate binding site [chemical binding]; other site 426355004412 metal binding site [ion binding]; metal-binding site 426355004413 PAS domain; Region: PAS_9; pfam13426 426355004414 PAS domain; Region: PAS_9; pfam13426 426355004415 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355004416 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355004417 metal binding site [ion binding]; metal-binding site 426355004418 active site 426355004419 I-site; other site 426355004420 Domain of unknown function (DUF892); Region: DUF892; pfam05974 426355004421 Predicted membrane protein [Function unknown]; Region: COG4270 426355004422 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 426355004423 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 426355004424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355004425 catalytic residue [active] 426355004426 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 426355004427 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 426355004428 glutamine binding [chemical binding]; other site 426355004429 catalytic triad [active] 426355004430 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 426355004431 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 426355004432 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 426355004433 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 426355004434 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 426355004435 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355004436 FeS/SAM binding site; other site 426355004437 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 426355004438 active site 426355004439 DNA polymerase IV; Validated; Region: PRK02406 426355004440 DNA binding site [nucleotide binding] 426355004441 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 426355004442 Isochorismatase family; Region: Isochorismatase; pfam00857 426355004443 metal binding site [ion binding]; metal-binding site 426355004444 catalytic triad [active] 426355004445 conserved cis-peptide bond; other site 426355004446 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 426355004447 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 426355004448 NADP binding site [chemical binding]; other site 426355004449 dimer interface [polypeptide binding]; other site 426355004450 Uncharacterized conserved protein [Function unknown]; Region: COG2938 426355004451 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 426355004452 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 426355004453 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426355004454 ATP binding site [chemical binding]; other site 426355004455 putative Mg++ binding site [ion binding]; other site 426355004456 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426355004457 nucleotide binding region [chemical binding]; other site 426355004458 ATP-binding site [chemical binding]; other site 426355004459 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 426355004460 muropeptide transporter; Reviewed; Region: ampG; PRK11902 426355004461 muropeptide transporter; Validated; Region: ampG; cl17669 426355004462 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 426355004463 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 426355004464 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 426355004465 putative active site [active] 426355004466 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 426355004467 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 426355004468 conserved cys residue [active] 426355004469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355004470 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 426355004471 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 426355004472 conserved cys residue [active] 426355004473 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 426355004474 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 426355004475 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 426355004476 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426355004477 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 426355004478 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 426355004479 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426355004480 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 426355004481 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 426355004482 generic binding surface II; other site 426355004483 ssDNA binding site; other site 426355004484 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426355004485 ATP binding site [chemical binding]; other site 426355004486 putative Mg++ binding site [ion binding]; other site 426355004487 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426355004488 nucleotide binding region [chemical binding]; other site 426355004489 ATP-binding site [chemical binding]; other site 426355004490 Uncharacterized conserved protein [Function unknown]; Region: COG2928 426355004491 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 426355004492 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 426355004493 substrate binding site [chemical binding]; other site 426355004494 ATP binding site [chemical binding]; other site 426355004495 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355004496 PAS fold; Region: PAS_3; pfam08447 426355004497 putative active site [active] 426355004498 heme pocket [chemical binding]; other site 426355004499 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426355004500 Helix-turn-helix; Region: HTH_3; pfam01381 426355004501 non-specific DNA binding site [nucleotide binding]; other site 426355004502 salt bridge; other site 426355004503 sequence-specific DNA binding site [nucleotide binding]; other site 426355004504 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355004505 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 426355004506 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 426355004507 Beta-lactamase; Region: Beta-lactamase; pfam00144 426355004508 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 426355004509 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 426355004510 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 426355004511 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426355004512 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426355004513 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 426355004514 chemotaxis protein; Reviewed; Region: PRK12798 426355004515 flagellar motor protein MotB; Validated; Region: motB; PRK05996 426355004516 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 426355004517 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 426355004518 ligand binding site [chemical binding]; other site 426355004519 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 426355004520 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 426355004521 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 426355004522 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 426355004523 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 426355004524 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 426355004525 FliP family; Region: FliP; cl00593 426355004526 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 426355004527 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 426355004528 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 426355004529 Uncharacterized conserved protein [Function unknown]; Region: COG3334 426355004530 flagellar basal body P-ring protein; Reviewed; Region: flgI; PRK12789 426355004531 Flagellar P-ring protein; Region: FlgI; pfam02119 426355004532 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 426355004533 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 426355004534 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12692 426355004535 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 426355004536 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 426355004537 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 426355004538 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 426355004539 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 426355004540 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 426355004541 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 426355004542 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355004543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 426355004544 active site 426355004545 phosphorylation site [posttranslational modification] 426355004546 intermolecular recognition site; other site 426355004547 dimerization interface [polypeptide binding]; other site 426355004548 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 426355004549 DNA binding site [nucleotide binding] 426355004550 Rod binding protein; Region: Rod-binding; pfam10135 426355004551 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK12780 426355004552 flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792 426355004553 FHIPEP family; Region: FHIPEP; pfam00771 426355004554 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK12781 426355004555 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 426355004556 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 426355004557 flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794 426355004558 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 426355004559 Flagellar protein FlaF; Region: FlaF; pfam07309 426355004560 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 426355004561 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 426355004562 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 426355004563 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 426355004564 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 426355004565 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 426355004566 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 426355004567 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 426355004568 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 426355004569 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 426355004570 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426355004571 Walker A motif; other site 426355004572 ATP binding site [chemical binding]; other site 426355004573 Walker B motif; other site 426355004574 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 426355004575 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 426355004576 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 426355004577 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 426355004578 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 426355004579 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 426355004580 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 426355004581 flagellar motor protein MotA; Validated; Region: PRK09110 426355004582 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 426355004583 Flagellar motor switch protein FliM; Region: FliM; pfam02154 426355004584 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 426355004585 flagellar motor switch protein FliN; Region: fliN; TIGR02480 426355004586 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 426355004587 FliG C-terminal domain; Region: FliG_C; pfam01706 426355004588 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK13109 426355004589 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 426355004590 malate synthase G; Provisional; Region: PRK02999 426355004591 active site 426355004592 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355004593 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355004594 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 426355004595 putative effector binding pocket; other site 426355004596 dimerization interface [polypeptide binding]; other site 426355004597 aldolase II superfamily protein; Provisional; Region: PRK07044 426355004598 intersubunit interface [polypeptide binding]; other site 426355004599 active site 426355004600 Zn2+ binding site [ion binding]; other site 426355004601 amidase; Provisional; Region: PRK07056 426355004602 amidase; Validated; Region: PRK05962 426355004603 short chain dehydrogenase; Provisional; Region: PRK08339 426355004604 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 426355004605 putative NAD(P) binding site [chemical binding]; other site 426355004606 putative active site [active] 426355004607 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 426355004608 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 426355004609 Probable Catalytic site; other site 426355004610 metal-binding site 426355004611 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 426355004612 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 426355004613 Probable Catalytic site; other site 426355004614 metal-binding site 426355004615 metabolite-proton symporter; Region: 2A0106; TIGR00883 426355004616 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 426355004617 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 426355004618 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 426355004619 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 426355004620 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 426355004621 D-pathway; other site 426355004622 Putative ubiquinol binding site [chemical binding]; other site 426355004623 Low-spin heme (heme b) binding site [chemical binding]; other site 426355004624 Putative water exit pathway; other site 426355004625 Binuclear center (heme o3/CuB) [ion binding]; other site 426355004626 K-pathway; other site 426355004627 Putative proton exit pathway; other site 426355004628 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 426355004629 Subunit I/III interface [polypeptide binding]; other site 426355004630 Subunit III/IV interface [polypeptide binding]; other site 426355004631 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 426355004632 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 426355004633 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 426355004634 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 426355004635 active site 426355004636 substrate binding site [chemical binding]; other site 426355004637 coenzyme B12 binding site [chemical binding]; other site 426355004638 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 426355004639 B12 binding site [chemical binding]; other site 426355004640 cobalt ligand [ion binding]; other site 426355004641 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426355004642 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 426355004643 phosphoglucomutase; Region: PLN02307 426355004644 active site 426355004645 substrate binding site [chemical binding]; other site 426355004646 metal binding site [ion binding]; metal-binding site 426355004647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426355004648 Coenzyme A binding pocket [chemical binding]; other site 426355004649 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 426355004650 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 426355004651 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426355004652 RNA binding surface [nucleotide binding]; other site 426355004653 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 426355004654 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 426355004655 UGMP family protein; Validated; Region: PRK09604 426355004656 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 426355004657 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 426355004658 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 426355004659 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 426355004660 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 426355004661 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 426355004662 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 426355004663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 426355004664 PAS domain; Region: PAS_9; pfam13426 426355004665 putative active site [active] 426355004666 heme pocket [chemical binding]; other site 426355004667 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355004668 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355004669 metal binding site [ion binding]; metal-binding site 426355004670 active site 426355004671 I-site; other site 426355004672 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355004673 EVE domain; Region: EVE; pfam01878 426355004674 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355004675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355004676 dimer interface [polypeptide binding]; other site 426355004677 phosphorylation site [posttranslational modification] 426355004678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355004679 ATP binding site [chemical binding]; other site 426355004680 Mg2+ binding site [ion binding]; other site 426355004681 G-X-G motif; other site 426355004682 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 426355004683 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355004684 catalytic loop [active] 426355004685 iron binding site [ion binding]; other site 426355004686 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426355004687 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426355004688 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426355004689 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355004690 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 426355004691 ligand binding site [chemical binding]; other site 426355004692 active site 426355004693 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 426355004694 active site 426355004695 dimer interface [polypeptide binding]; other site 426355004696 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 426355004697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426355004698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355004699 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426355004700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355004701 NAD(P) binding site [chemical binding]; other site 426355004702 active site 426355004703 Isochorismatase family; Region: Isochorismatase; pfam00857 426355004704 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 426355004705 catalytic triad [active] 426355004706 conserved cis-peptide bond; other site 426355004707 Domain of unknown function (DUF892); Region: DUF892; pfam05974 426355004708 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355004709 putative active site [active] 426355004710 PAS fold; Region: PAS_3; pfam08447 426355004711 heme pocket [chemical binding]; other site 426355004712 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426355004713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355004714 putative PBP binding loops; other site 426355004715 dimer interface [polypeptide binding]; other site 426355004716 ABC-ATPase subunit interface; other site 426355004717 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 426355004718 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426355004719 Walker A/P-loop; other site 426355004720 ATP binding site [chemical binding]; other site 426355004721 Q-loop/lid; other site 426355004722 ABC transporter signature motif; other site 426355004723 Walker B; other site 426355004724 D-loop; other site 426355004725 H-loop/switch region; other site 426355004726 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 426355004727 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355004728 substrate binding pocket [chemical binding]; other site 426355004729 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 426355004730 membrane-bound complex binding site; other site 426355004731 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 426355004732 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355004733 dimerization interface [polypeptide binding]; other site 426355004734 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355004735 dimer interface [polypeptide binding]; other site 426355004736 putative CheW interface [polypeptide binding]; other site 426355004737 PAS fold; Region: PAS_7; pfam12860 426355004738 PAS domain S-box; Region: sensory_box; TIGR00229 426355004739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355004740 putative active site [active] 426355004741 heme pocket [chemical binding]; other site 426355004742 PAS domain S-box; Region: sensory_box; TIGR00229 426355004743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355004744 putative active site [active] 426355004745 heme pocket [chemical binding]; other site 426355004746 PAS fold; Region: PAS_3; pfam08447 426355004747 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355004748 dimer interface [polypeptide binding]; other site 426355004749 phosphorylation site [posttranslational modification] 426355004750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355004751 ATP binding site [chemical binding]; other site 426355004752 Mg2+ binding site [ion binding]; other site 426355004753 G-X-G motif; other site 426355004754 Response regulator receiver domain; Region: Response_reg; pfam00072 426355004755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355004756 active site 426355004757 phosphorylation site [posttranslational modification] 426355004758 intermolecular recognition site; other site 426355004759 dimerization interface [polypeptide binding]; other site 426355004760 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 426355004761 putative binding surface; other site 426355004762 active site 426355004763 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 426355004764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355004765 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 426355004766 maltose O-acetyltransferase; Provisional; Region: PRK10092 426355004767 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 426355004768 active site 426355004769 substrate binding site [chemical binding]; other site 426355004770 trimer interface [polypeptide binding]; other site 426355004771 CoA binding site [chemical binding]; other site 426355004772 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 426355004773 Omptin family; Region: Omptin; cl01886 426355004774 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 426355004775 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 426355004776 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 426355004777 dimerization interface [polypeptide binding]; other site 426355004778 ligand binding site [chemical binding]; other site 426355004779 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355004780 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 426355004781 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 426355004782 putative dimerization interface [polypeptide binding]; other site 426355004783 putative substrate binding pocket [chemical binding]; other site 426355004784 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 426355004785 tartronate semialdehyde reductase; Provisional; Region: PRK15059 426355004786 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426355004787 galactarate dehydratase; Region: galactar-dH20; TIGR03248 426355004788 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 426355004789 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 426355004790 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 426355004791 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 426355004792 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 426355004793 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426355004794 N-terminal plug; other site 426355004795 ligand-binding site [chemical binding]; other site 426355004796 sulfite reductase subunit beta; Provisional; Region: PRK13504 426355004797 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 426355004798 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 426355004799 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 426355004800 Flavodoxin; Region: Flavodoxin_1; pfam00258 426355004801 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 426355004802 FAD binding pocket [chemical binding]; other site 426355004803 FAD binding motif [chemical binding]; other site 426355004804 catalytic residues [active] 426355004805 NAD binding pocket [chemical binding]; other site 426355004806 phosphate binding motif [ion binding]; other site 426355004807 beta-alpha-beta structure motif; other site 426355004808 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 426355004809 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426355004810 dimerization interface [polypeptide binding]; other site 426355004811 putative DNA binding site [nucleotide binding]; other site 426355004812 putative Zn2+ binding site [ion binding]; other site 426355004813 AsnC family; Region: AsnC_trans_reg; pfam01037 426355004814 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 426355004815 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 426355004816 Active Sites [active] 426355004817 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 426355004818 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 426355004819 Active Sites [active] 426355004820 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 426355004821 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 426355004822 CysD dimerization site [polypeptide binding]; other site 426355004823 G1 box; other site 426355004824 putative GEF interaction site [polypeptide binding]; other site 426355004825 GTP/Mg2+ binding site [chemical binding]; other site 426355004826 Switch I region; other site 426355004827 G2 box; other site 426355004828 G3 box; other site 426355004829 Switch II region; other site 426355004830 G4 box; other site 426355004831 G5 box; other site 426355004832 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 426355004833 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 426355004834 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 426355004835 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 426355004836 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 426355004837 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 426355004838 aspartate aminotransferase; Provisional; Region: PRK05764 426355004839 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426355004840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355004841 homodimer interface [polypeptide binding]; other site 426355004842 catalytic residue [active] 426355004843 PemK-like protein; Region: PemK; pfam02452 426355004844 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 426355004845 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 426355004846 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 426355004847 EamA-like transporter family; Region: EamA; pfam00892 426355004848 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 426355004849 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 426355004850 active site 426355004851 HIGH motif; other site 426355004852 nucleotide binding site [chemical binding]; other site 426355004853 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 426355004854 active site 426355004855 KMSKS motif; other site 426355004856 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 426355004857 tRNA binding surface [nucleotide binding]; other site 426355004858 anticodon binding site; other site 426355004859 lipoprotein signal peptidase; Provisional; Region: PRK14796 426355004860 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 426355004861 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 426355004862 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 426355004863 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 426355004864 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 426355004865 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 426355004866 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426355004867 Zn binding site [ion binding]; other site 426355004868 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 426355004869 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426355004870 Zn binding site [ion binding]; other site 426355004871 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 426355004872 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 426355004873 FAD binding pocket [chemical binding]; other site 426355004874 FAD binding motif [chemical binding]; other site 426355004875 phosphate binding motif [ion binding]; other site 426355004876 beta-alpha-beta structure motif; other site 426355004877 NAD binding pocket [chemical binding]; other site 426355004878 Helix-turn-helix; Region: HTH_3; pfam01381 426355004879 non-specific DNA binding site [nucleotide binding]; other site 426355004880 salt bridge; other site 426355004881 sequence-specific DNA binding site [nucleotide binding]; other site 426355004882 TROVE domain; Region: TROVE; pfam05731 426355004883 Protein of unknown function; Region: DUF3971; pfam13116 426355004884 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 426355004885 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 426355004886 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 426355004887 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 426355004888 catalytic triad [active] 426355004889 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 426355004890 Peptidase family M23; Region: Peptidase_M23; pfam01551 426355004891 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 426355004892 putative active site [active] 426355004893 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 426355004894 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 426355004895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355004896 NAD(P) binding site [chemical binding]; other site 426355004897 active site 426355004898 Putative cyclase; Region: Cyclase; cl00814 426355004899 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355004900 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_10; cd06345 426355004901 putative ligand binding site [chemical binding]; other site 426355004902 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426355004903 TM-ABC transporter signature motif; other site 426355004904 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426355004905 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426355004906 TM-ABC transporter signature motif; other site 426355004907 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426355004908 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426355004909 Walker A/P-loop; other site 426355004910 ATP binding site [chemical binding]; other site 426355004911 Q-loop/lid; other site 426355004912 ABC transporter signature motif; other site 426355004913 Walker B; other site 426355004914 D-loop; other site 426355004915 H-loop/switch region; other site 426355004916 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426355004917 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426355004918 Walker A/P-loop; other site 426355004919 ATP binding site [chemical binding]; other site 426355004920 Q-loop/lid; other site 426355004921 ABC transporter signature motif; other site 426355004922 Walker B; other site 426355004923 D-loop; other site 426355004924 H-loop/switch region; other site 426355004925 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426355004926 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426355004927 active site 426355004928 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 426355004929 Phosphotransferase enzyme family; Region: APH; pfam01636 426355004930 putative active site [active] 426355004931 putative substrate binding site [chemical binding]; other site 426355004932 ATP binding site [chemical binding]; other site 426355004933 classical (c) SDRs; Region: SDR_c; cd05233 426355004934 NAD(P) binding site [chemical binding]; other site 426355004935 active site 426355004936 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 426355004937 classical (c) SDRs; Region: SDR_c; cd05233 426355004938 NAD(P) binding site [chemical binding]; other site 426355004939 active site 426355004940 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 426355004941 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426355004942 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 426355004943 acyl-activating enzyme (AAE) consensus motif; other site 426355004944 putative AMP binding site [chemical binding]; other site 426355004945 putative active site [active] 426355004946 putative CoA binding site [chemical binding]; other site 426355004947 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 426355004948 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426355004949 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 426355004950 Cytochrome P450; Region: p450; cl12078 426355004951 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 426355004952 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355004953 dimerization interface [polypeptide binding]; other site 426355004954 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355004955 dimer interface [polypeptide binding]; other site 426355004956 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 426355004957 putative CheW interface [polypeptide binding]; other site 426355004958 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 426355004959 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 426355004960 Peptidase C26; Region: Peptidase_C26; pfam07722 426355004961 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 426355004962 catalytic triad [active] 426355004963 putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056 426355004964 magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406 426355004965 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 426355004966 metal ion-dependent adhesion site (MIDAS); other site 426355004967 magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407 426355004968 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 426355004969 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 426355004970 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 426355004971 substrate-cofactor binding pocket; other site 426355004972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355004973 catalytic residue [active] 426355004974 Protein of unknown function (DUF3623); Region: DUF3623; pfam12291 426355004975 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 426355004976 diiron binding motif [ion binding]; other site 426355004977 putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054 426355004978 Bacterial PH domain; Region: DUF304; cl01348 426355004979 photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150 426355004980 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581 426355004981 subunit C interaction residues; other site 426355004982 subunit M interaction residues [polypeptide binding]; other site 426355004983 subunit L interaction residues [polypeptide binding]; other site 426355004984 putative proton transfer pathway, P1; other site 426355004985 putative proton transfer pathway, P2; other site 426355004986 PUCC protein; Region: PUCC; pfam03209 426355004987 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 426355004988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355004989 S-adenosylmethionine binding site [chemical binding]; other site 426355004990 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 426355004991 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 426355004992 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 426355004993 P-loop; other site 426355004994 magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405 426355004995 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 426355004996 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 426355004997 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 426355004998 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 426355004999 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 426355005000 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 426355005001 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 426355005002 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 426355005003 B12 binding domain; Region: B12-binding; pfam02310 426355005004 B12 binding site [chemical binding]; other site 426355005005 transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040 426355005006 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355005007 putative active site [active] 426355005008 heme pocket [chemical binding]; other site 426355005009 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 426355005010 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 426355005011 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 426355005012 UbiA prenyltransferase family; Region: UbiA; pfam01040 426355005013 PUCC protein; Region: PUCC; pfam03209 426355005014 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 426355005015 TspO/MBR family; Region: TspO_MBR; pfam03073 426355005016 Cytochrome c; Region: Cytochrom_C; pfam00034 426355005017 Cytochrome c; Region: Cytochrom_C; pfam00034 426355005018 Cytochrome c; Region: Cytochrom_C; pfam00034 426355005019 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 426355005020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 426355005021 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 426355005022 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 426355005023 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 426355005024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 426355005025 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 426355005026 response regulator PleD; Reviewed; Region: pleD; PRK09581 426355005027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005028 active site 426355005029 phosphorylation site [posttranslational modification] 426355005030 intermolecular recognition site; other site 426355005031 dimerization interface [polypeptide binding]; other site 426355005032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005033 active site 426355005034 phosphorylation site [posttranslational modification] 426355005035 intermolecular recognition site; other site 426355005036 dimerization interface [polypeptide binding]; other site 426355005037 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355005038 metal binding site [ion binding]; metal-binding site 426355005039 active site 426355005040 I-site; other site 426355005041 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355005042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005043 active site 426355005044 phosphorylation site [posttranslational modification] 426355005045 intermolecular recognition site; other site 426355005046 dimerization interface [polypeptide binding]; other site 426355005047 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 426355005048 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 426355005049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355005050 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 426355005051 Walker A/P-loop; other site 426355005052 ATP binding site [chemical binding]; other site 426355005053 Q-loop/lid; other site 426355005054 ABC transporter signature motif; other site 426355005055 Walker B; other site 426355005056 D-loop; other site 426355005057 H-loop/switch region; other site 426355005058 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 426355005059 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 426355005060 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 426355005061 putative active site [active] 426355005062 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 426355005063 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 426355005064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355005065 catalytic residue [active] 426355005066 methionine sulfoxide reductase A; Provisional; Region: PRK13014 426355005067 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 426355005068 prephenate dehydrogenase; Validated; Region: PRK08507 426355005069 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 426355005070 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426355005071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355005072 homodimer interface [polypeptide binding]; other site 426355005073 catalytic residue [active] 426355005074 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 426355005075 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 426355005076 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426355005077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355005078 S-adenosylmethionine binding site [chemical binding]; other site 426355005079 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 426355005080 ligand-binding site [chemical binding]; other site 426355005081 sensor protein PhoQ; Provisional; Region: PRK10815 426355005082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355005083 ATP binding site [chemical binding]; other site 426355005084 Mg2+ binding site [ion binding]; other site 426355005085 G-X-G motif; other site 426355005086 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355005087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005088 active site 426355005089 phosphorylation site [posttranslational modification] 426355005090 intermolecular recognition site; other site 426355005091 dimerization interface [polypeptide binding]; other site 426355005092 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355005093 DNA binding site [nucleotide binding] 426355005094 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 426355005095 Staphylococcal nuclease homologues; Region: SNc; smart00318 426355005096 Catalytic site; other site 426355005097 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 426355005098 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 426355005099 putative heme binding pocket [chemical binding]; other site 426355005100 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 426355005101 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426355005102 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426355005103 catalytic residue [active] 426355005104 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 426355005105 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 426355005106 dimer interface [polypeptide binding]; other site 426355005107 active site 426355005108 catalytic residue [active] 426355005109 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 426355005110 SmpB-tmRNA interface; other site 426355005111 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 426355005112 catalytic triad [active] 426355005113 Uncharacterized conserved protein [Function unknown]; Region: COG1432 426355005114 LabA_like proteins; Region: LabA; cd10911 426355005115 putative metal binding site [ion binding]; other site 426355005116 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 426355005117 HD domain; Region: HD_4; pfam13328 426355005118 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 426355005119 synthetase active site [active] 426355005120 NTP binding site [chemical binding]; other site 426355005121 metal binding site [ion binding]; metal-binding site 426355005122 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 426355005123 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 426355005124 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 426355005125 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 426355005126 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 426355005127 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 426355005128 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 426355005129 NAD(P) binding site [chemical binding]; other site 426355005130 homotetramer interface [polypeptide binding]; other site 426355005131 homodimer interface [polypeptide binding]; other site 426355005132 active site 426355005133 acyl carrier protein; Provisional; Region: acpP; PRK00982 426355005134 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 426355005135 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 426355005136 dimer interface [polypeptide binding]; other site 426355005137 active site 426355005138 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 426355005139 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 426355005140 Phasin protein; Region: Phasin_2; cl11491 426355005141 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 426355005142 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355005143 PAS fold; Region: PAS_7; pfam12860 426355005144 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355005145 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355005146 metal binding site [ion binding]; metal-binding site 426355005147 active site 426355005148 I-site; other site 426355005149 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 426355005150 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 426355005151 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 426355005152 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 426355005153 active site 426355005154 dimer interface [polypeptide binding]; other site 426355005155 motif 1; other site 426355005156 motif 2; other site 426355005157 motif 3; other site 426355005158 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 426355005159 anticodon binding site; other site 426355005160 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 426355005161 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426355005162 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426355005163 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 426355005164 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 426355005165 Walker A/P-loop; other site 426355005166 ATP binding site [chemical binding]; other site 426355005167 Q-loop/lid; other site 426355005168 ABC transporter signature motif; other site 426355005169 Walker B; other site 426355005170 D-loop; other site 426355005171 H-loop/switch region; other site 426355005172 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 426355005173 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 426355005174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355005175 DNA-binding site [nucleotide binding]; DNA binding site 426355005176 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426355005177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355005178 homodimer interface [polypeptide binding]; other site 426355005179 catalytic residue [active] 426355005180 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 426355005181 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 426355005182 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 426355005183 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 426355005184 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 426355005185 Trp docking motif [polypeptide binding]; other site 426355005186 dimer interface [polypeptide binding]; other site 426355005187 active site 426355005188 small subunit binding site [polypeptide binding]; other site 426355005189 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 426355005190 active site 426355005191 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 426355005192 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 426355005193 Autotransporter beta-domain; Region: Autotransporter; smart00869 426355005194 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355005195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355005196 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 426355005197 putative effector binding pocket; other site 426355005198 putative dimerization interface [polypeptide binding]; other site 426355005199 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426355005200 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426355005201 active site 426355005202 catalytic tetrad [active] 426355005203 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355005204 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426355005205 putative ligand binding site [chemical binding]; other site 426355005206 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 426355005207 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 426355005208 classical (c) SDRs; Region: SDR_c; cd05233 426355005209 NAD(P) binding site [chemical binding]; other site 426355005210 active site 426355005211 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 426355005212 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 426355005213 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 426355005214 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426355005215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355005216 Walker A motif; other site 426355005217 ATP binding site [chemical binding]; other site 426355005218 Walker B motif; other site 426355005219 arginine finger; other site 426355005220 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 426355005221 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 426355005222 TrkA-N domain; Region: TrkA_N; pfam02254 426355005223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 426355005224 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 426355005225 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355005226 catalytic loop [active] 426355005227 iron binding site [ion binding]; other site 426355005228 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 426355005229 putative binding surface; other site 426355005230 active site 426355005231 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 426355005232 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 426355005233 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 426355005234 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 426355005235 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 426355005236 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 426355005237 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 426355005238 Permease; Region: Permease; pfam02405 426355005239 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 426355005240 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 426355005241 Walker A/P-loop; other site 426355005242 ATP binding site [chemical binding]; other site 426355005243 Q-loop/lid; other site 426355005244 ABC transporter signature motif; other site 426355005245 Walker B; other site 426355005246 D-loop; other site 426355005247 H-loop/switch region; other site 426355005248 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 426355005249 mce related protein; Region: MCE; pfam02470 426355005250 Protein of unknown function (DUF330); Region: DUF330; cl01135 426355005251 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 426355005252 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355005253 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426355005254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355005255 non-specific DNA binding site [nucleotide binding]; other site 426355005256 salt bridge; other site 426355005257 sequence-specific DNA binding site [nucleotide binding]; other site 426355005258 Cupin domain; Region: Cupin_2; pfam07883 426355005259 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 426355005260 dimer interface [polypeptide binding]; other site 426355005261 substrate binding site [chemical binding]; other site 426355005262 ATP binding site [chemical binding]; other site 426355005263 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 426355005264 active site 426355005265 thiamine phosphate binding site [chemical binding]; other site 426355005266 pyrophosphate binding site [ion binding]; other site 426355005267 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 426355005268 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 426355005269 Domain of unknown function (DUF333); Region: DUF333; pfam03891 426355005270 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 426355005271 active site 426355005272 oligomerization interface [polypeptide binding]; other site 426355005273 metal binding site [ion binding]; metal-binding site 426355005274 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 426355005275 active site residue [active] 426355005276 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 426355005277 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 426355005278 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426355005279 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355005280 division inhibitor protein; Provisional; Region: slmA; PRK09480 426355005281 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 426355005282 Ligand Binding Site [chemical binding]; other site 426355005283 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 426355005284 active site 426355005285 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 426355005286 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 426355005287 inhibitor site; inhibition site 426355005288 active site 426355005289 dimer interface [polypeptide binding]; other site 426355005290 catalytic residue [active] 426355005291 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426355005292 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355005293 DNA-binding site [nucleotide binding]; DNA binding site 426355005294 FCD domain; Region: FCD; pfam07729 426355005295 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426355005296 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 426355005297 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 426355005298 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 426355005299 putative dimer interface [polypeptide binding]; other site 426355005300 active site pocket [active] 426355005301 putative cataytic base [active] 426355005302 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 426355005303 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 426355005304 Predicted aspartyl protease [General function prediction only]; Region: COG3577 426355005305 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 426355005306 catalytic motif [active] 426355005307 Catalytic residue [active] 426355005308 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 426355005309 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 426355005310 FMN binding site [chemical binding]; other site 426355005311 active site 426355005312 catalytic residues [active] 426355005313 substrate binding site [chemical binding]; other site 426355005314 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 426355005315 flagellar motor stator protein MotA; Region: MotA1; TIGR03818 426355005316 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 426355005317 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 426355005318 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 426355005319 ligand binding site [chemical binding]; other site 426355005320 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 426355005321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355005322 dimerization interface [polypeptide binding]; other site 426355005323 AAA domain; Region: AAA_21; pfam13304 426355005324 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 426355005325 active site 426355005326 metal binding site [ion binding]; metal-binding site 426355005327 AAA domain; Region: AAA_25; pfam13481 426355005328 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426355005329 ATP binding site [chemical binding]; other site 426355005330 Walker B motif; other site 426355005331 Toprim domain; Region: Toprim_3; pfam13362 426355005332 Helix-turn-helix domain; Region: HTH_17; pfam12728 426355005333 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 426355005334 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 426355005335 active site 426355005336 Int/Topo IB signature motif; other site 426355005337 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355005338 short chain dehydrogenase; Provisional; Region: PRK06701 426355005339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355005340 NAD(P) binding site [chemical binding]; other site 426355005341 active site 426355005342 Uncharacterized conserved protein [Function unknown]; Region: COG3791 426355005343 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 426355005344 UreE urease accessory protein, C-terminal domain; Region: UreE_C; pfam05194 426355005345 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 426355005346 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 426355005347 putative metal binding site [ion binding]; other site 426355005348 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 426355005349 HSP70 interaction site [polypeptide binding]; other site 426355005350 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 426355005351 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 426355005352 amidase catalytic site [active] 426355005353 Zn binding residues [ion binding]; other site 426355005354 substrate binding site [chemical binding]; other site 426355005355 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426355005356 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 426355005357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355005358 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426355005359 putative substrate translocation pore; other site 426355005360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355005361 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 426355005362 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 426355005363 DNA Polymerase Y-family; Region: PolY_like; cd03468 426355005364 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 426355005365 active site 426355005366 DNA binding site [nucleotide binding] 426355005367 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 426355005368 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 426355005369 putative active site [active] 426355005370 putative PHP Thumb interface [polypeptide binding]; other site 426355005371 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 426355005372 generic binding surface II; other site 426355005373 generic binding surface I; other site 426355005374 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 426355005375 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 426355005376 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 426355005377 LexA repressor; Validated; Region: PRK00215 426355005378 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 426355005379 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 426355005380 Catalytic site [active] 426355005381 Competence protein; Region: Competence; pfam03772 426355005382 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 426355005383 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 426355005384 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 426355005385 active site 426355005386 HIGH motif; other site 426355005387 nucleotide binding site [chemical binding]; other site 426355005388 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 426355005389 active site 426355005390 KMSKS motif; other site 426355005391 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 426355005392 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 426355005393 dimer interface [polypeptide binding]; other site 426355005394 active site 426355005395 citrylCoA binding site [chemical binding]; other site 426355005396 NADH binding [chemical binding]; other site 426355005397 cationic pore residues; other site 426355005398 oxalacetate/citrate binding site [chemical binding]; other site 426355005399 coenzyme A binding site [chemical binding]; other site 426355005400 catalytic triad [active] 426355005401 AlkA N-terminal domain; Region: AlkA_N; pfam06029 426355005402 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 426355005403 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 426355005404 minor groove reading motif; other site 426355005405 helix-hairpin-helix signature motif; other site 426355005406 substrate binding pocket [chemical binding]; other site 426355005407 active site 426355005408 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 426355005409 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 426355005410 CAP-like domain; other site 426355005411 active site 426355005412 primary dimer interface [polypeptide binding]; other site 426355005413 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 426355005414 Recombination protein O N terminal; Region: RecO_N; pfam11967 426355005415 Recombination protein O C terminal; Region: RecO_C; pfam02565 426355005416 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 426355005417 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 426355005418 putative active site pocket [active] 426355005419 dimerization interface [polypeptide binding]; other site 426355005420 putative catalytic residue [active] 426355005421 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 426355005422 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 426355005423 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 426355005424 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 426355005425 putative active site [active] 426355005426 putative PHP Thumb interface [polypeptide binding]; other site 426355005427 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 426355005428 generic binding surface II; other site 426355005429 generic binding surface I; other site 426355005430 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 426355005431 active site 426355005432 TDP-binding site; other site 426355005433 acceptor substrate-binding pocket; other site 426355005434 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 426355005435 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 426355005436 Walker A/P-loop; other site 426355005437 ATP binding site [chemical binding]; other site 426355005438 Q-loop/lid; other site 426355005439 ABC transporter signature motif; other site 426355005440 Walker B; other site 426355005441 D-loop; other site 426355005442 H-loop/switch region; other site 426355005443 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 426355005444 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 426355005445 FtsX-like permease family; Region: FtsX; pfam02687 426355005446 prolyl-tRNA synthetase; Provisional; Region: PRK12325 426355005447 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 426355005448 dimer interface [polypeptide binding]; other site 426355005449 motif 1; other site 426355005450 active site 426355005451 motif 2; other site 426355005452 motif 3; other site 426355005453 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 426355005454 anticodon binding site; other site 426355005455 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 426355005456 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426355005457 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 426355005458 dimer interface [polypeptide binding]; other site 426355005459 substrate binding site [chemical binding]; other site 426355005460 metal binding site [ion binding]; metal-binding site 426355005461 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 426355005462 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426355005463 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 426355005464 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 426355005465 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 426355005466 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 426355005467 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 426355005468 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 426355005469 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 426355005470 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 426355005471 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 426355005472 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 426355005473 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 426355005474 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 426355005475 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 426355005476 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 426355005477 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 426355005478 4Fe-4S binding domain; Region: Fer4; pfam00037 426355005479 4Fe-4S binding domain; Region: Fer4; pfam00037 426355005480 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 426355005481 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 426355005482 NADH dehydrogenase subunit G; Validated; Region: PRK09130 426355005483 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355005484 catalytic loop [active] 426355005485 iron binding site [ion binding]; other site 426355005486 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 426355005487 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 426355005488 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 426355005489 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 426355005490 SLBB domain; Region: SLBB; pfam10531 426355005491 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 426355005492 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 426355005493 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 426355005494 putative dimer interface [polypeptide binding]; other site 426355005495 [2Fe-2S] cluster binding site [ion binding]; other site 426355005496 Uncharacterized conserved protein [Function unknown]; Region: COG3743 426355005497 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 426355005498 NADH dehydrogenase subunit D; Validated; Region: PRK06075 426355005499 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 426355005500 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 426355005501 NADH dehydrogenase subunit B; Validated; Region: PRK06411 426355005502 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 426355005503 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 426355005504 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 426355005505 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 426355005506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355005507 DNA-binding site [nucleotide binding]; DNA binding site 426355005508 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426355005509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355005510 homodimer interface [polypeptide binding]; other site 426355005511 catalytic residue [active] 426355005512 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355005513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355005514 ATP binding site [chemical binding]; other site 426355005515 Mg2+ binding site [ion binding]; other site 426355005516 G-X-G motif; other site 426355005517 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 426355005518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005519 active site 426355005520 phosphorylation site [posttranslational modification] 426355005521 intermolecular recognition site; other site 426355005522 dimerization interface [polypeptide binding]; other site 426355005523 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355005524 DNA binding site [nucleotide binding] 426355005525 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 426355005526 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 426355005527 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355005528 Walker A/P-loop; other site 426355005529 ATP binding site [chemical binding]; other site 426355005530 Q-loop/lid; other site 426355005531 ABC transporter signature motif; other site 426355005532 Walker B; other site 426355005533 D-loop; other site 426355005534 H-loop/switch region; other site 426355005535 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 426355005536 active site 426355005537 catalytic residues [active] 426355005538 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 426355005539 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 426355005540 active site 426355005541 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 426355005542 HemY protein N-terminus; Region: HemY_N; pfam07219 426355005543 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 426355005544 nudix motif; other site 426355005545 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 426355005546 dimanganese center [ion binding]; other site 426355005547 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 426355005548 putative homodimer interface [polypeptide binding]; other site 426355005549 putative homotetramer interface [polypeptide binding]; other site 426355005550 putative allosteric switch controlling residues; other site 426355005551 putative metal binding site [ion binding]; other site 426355005552 putative homodimer-homodimer interface [polypeptide binding]; other site 426355005553 RNA polymerase sigma factor; Provisional; Region: PRK12547 426355005554 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355005555 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426355005556 DNA binding residues [nucleotide binding] 426355005557 TonB C terminal; Region: TonB_2; pfam13103 426355005558 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 426355005559 TadE-like protein; Region: TadE; pfam07811 426355005560 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 426355005561 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 426355005562 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 426355005563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005564 active site 426355005565 phosphorylation site [posttranslational modification] 426355005566 intermolecular recognition site; other site 426355005567 dimerization interface [polypeptide binding]; other site 426355005568 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426355005569 Zn2+ binding site [ion binding]; other site 426355005570 Mg2+ binding site [ion binding]; other site 426355005571 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355005572 dimerization interface [polypeptide binding]; other site 426355005573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355005574 dimer interface [polypeptide binding]; other site 426355005575 phosphorylation site [posttranslational modification] 426355005576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355005577 ATP binding site [chemical binding]; other site 426355005578 Mg2+ binding site [ion binding]; other site 426355005579 G-X-G motif; other site 426355005580 Response regulator receiver domain; Region: Response_reg; pfam00072 426355005581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005582 active site 426355005583 phosphorylation site [posttranslational modification] 426355005584 intermolecular recognition site; other site 426355005585 dimerization interface [polypeptide binding]; other site 426355005586 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 426355005587 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 426355005588 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355005589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005590 active site 426355005591 phosphorylation site [posttranslational modification] 426355005592 intermolecular recognition site; other site 426355005593 PAS domain S-box; Region: sensory_box; TIGR00229 426355005594 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355005595 putative active site [active] 426355005596 heme pocket [chemical binding]; other site 426355005597 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355005598 HWE histidine kinase; Region: HWE_HK; pfam07536 426355005599 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 426355005600 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 426355005601 active site 426355005602 catalytic residues [active] 426355005603 metal binding site [ion binding]; metal-binding site 426355005604 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 426355005605 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355005606 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 426355005607 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 426355005608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355005609 NAD(P) binding site [chemical binding]; other site 426355005610 active site 426355005611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355005612 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 426355005613 Walker A/P-loop; other site 426355005614 ATP binding site [chemical binding]; other site 426355005615 Q-loop/lid; other site 426355005616 ABC transporter signature motif; other site 426355005617 Walker B; other site 426355005618 D-loop; other site 426355005619 H-loop/switch region; other site 426355005620 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426355005621 ABC transporter; Region: ABC_tran; pfam00005 426355005622 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 426355005623 cyclase homology domain; Region: CHD; cd07302 426355005624 nucleotidyl binding site; other site 426355005625 metal binding site [ion binding]; metal-binding site 426355005626 dimer interface [polypeptide binding]; other site 426355005627 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 426355005628 homodimer interface [polypeptide binding]; other site 426355005629 glycosyltransferase, MGT family; Region: MGT; TIGR01426 426355005630 active site 426355005631 TDP-binding site; other site 426355005632 acceptor substrate-binding pocket; other site 426355005633 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 426355005634 Cytochrome P450; Region: p450; cl12078 426355005635 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426355005636 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 426355005637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355005638 putative substrate translocation pore; other site 426355005639 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426355005640 two-component response regulator VirG; Provisional; Region: PRK13856 426355005641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005642 active site 426355005643 phosphorylation site [posttranslational modification] 426355005644 intermolecular recognition site; other site 426355005645 dimerization interface [polypeptide binding]; other site 426355005646 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355005647 DNA binding site [nucleotide binding] 426355005648 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 426355005649 two-component VirA-like sensor kinase; Provisional; Region: PRK13837 426355005650 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 426355005651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355005652 dimer interface [polypeptide binding]; other site 426355005653 phosphorylation site [posttranslational modification] 426355005654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355005655 ATP binding site [chemical binding]; other site 426355005656 Mg2+ binding site [ion binding]; other site 426355005657 G-X-G motif; other site 426355005658 GAF domain; Region: GAF; pfam01590 426355005659 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355005660 PAS domain; Region: PAS_9; pfam13426 426355005661 putative active site [active] 426355005662 heme pocket [chemical binding]; other site 426355005663 PAS fold; Region: PAS_4; pfam08448 426355005664 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355005665 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355005666 dimer interface [polypeptide binding]; other site 426355005667 phosphorylation site [posttranslational modification] 426355005668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355005669 ATP binding site [chemical binding]; other site 426355005670 Mg2+ binding site [ion binding]; other site 426355005671 G-X-G motif; other site 426355005672 Response regulator receiver domain; Region: Response_reg; pfam00072 426355005673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005674 active site 426355005675 phosphorylation site [posttranslational modification] 426355005676 intermolecular recognition site; other site 426355005677 dimerization interface [polypeptide binding]; other site 426355005678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355005679 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 426355005680 NAD(P) binding site [chemical binding]; other site 426355005681 active site 426355005682 Cupin; Region: Cupin_6; pfam12852 426355005683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355005684 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426355005685 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355005686 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 426355005687 putative cation:proton antiport protein; Provisional; Region: PRK10669 426355005688 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 426355005689 TrkA-N domain; Region: TrkA_N; pfam02254 426355005690 HD domain; Region: HD_4; pfam13328 426355005691 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 426355005692 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 426355005693 dimer interface [polypeptide binding]; other site 426355005694 NADP binding site [chemical binding]; other site 426355005695 catalytic residues [active] 426355005696 thiamine pyrophosphate protein; Validated; Region: PRK08199 426355005697 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426355005698 PYR/PP interface [polypeptide binding]; other site 426355005699 dimer interface [polypeptide binding]; other site 426355005700 TPP binding site [chemical binding]; other site 426355005701 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426355005702 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 426355005703 TPP-binding site [chemical binding]; other site 426355005704 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426355005705 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355005706 DNA-binding site [nucleotide binding]; DNA binding site 426355005707 FCD domain; Region: FCD; pfam07729 426355005708 hypothetical protein; Validated; Region: PRK08245 426355005709 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 426355005710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355005711 putative substrate translocation pore; other site 426355005712 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 426355005713 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 426355005714 Strictosidine synthase; Region: Str_synth; pfam03088 426355005715 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 426355005716 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 426355005717 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 426355005718 substrate binding pocket [chemical binding]; other site 426355005719 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 426355005720 B12 binding site [chemical binding]; other site 426355005721 cobalt ligand [ion binding]; other site 426355005722 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 426355005723 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 426355005724 FAD binding site [chemical binding]; other site 426355005725 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426355005726 dimerization interface [polypeptide binding]; other site 426355005727 putative DNA binding site [nucleotide binding]; other site 426355005728 putative Zn2+ binding site [ion binding]; other site 426355005729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355005730 Methyltransferase domain; Region: Methyltransf_31; pfam13847 426355005731 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426355005732 catalytic core [active] 426355005733 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 426355005734 fructokinase; Reviewed; Region: PRK09557 426355005735 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 426355005736 nucleotide binding site [chemical binding]; other site 426355005737 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 426355005738 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 426355005739 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 426355005740 putative metal binding residues [ion binding]; other site 426355005741 methionine sulfoxide reductase B; Provisional; Region: PRK00222 426355005742 SelR domain; Region: SelR; pfam01641 426355005743 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 426355005744 UV-endonuclease UvdE; Region: UvdE; cl10036 426355005745 Serine hydrolase; Region: Ser_hydrolase; pfam06821 426355005746 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426355005747 hypothetical protein; Provisional; Region: PRK05415 426355005748 Domain of unknown function (DUF697); Region: DUF697; cl12064 426355005749 YcjX-like family, DUF463; Region: DUF463; pfam04317 426355005750 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 426355005751 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 426355005752 active site 426355005753 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 426355005754 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 426355005755 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 426355005756 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 426355005757 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 426355005758 active site 426355005759 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 426355005760 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 426355005761 Domain of unknown function DUF59; Region: DUF59; pfam01883 426355005762 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 426355005763 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 426355005764 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 426355005765 GTP binding site; other site 426355005766 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 426355005767 active site 426355005768 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 426355005769 active site 426355005770 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 426355005771 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 426355005772 active site 426355005773 (T/H)XGH motif; other site 426355005774 DNA gyrase subunit A; Validated; Region: PRK05560 426355005775 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 426355005776 CAP-like domain; other site 426355005777 active site 426355005778 primary dimer interface [polypeptide binding]; other site 426355005779 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 426355005780 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 426355005781 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 426355005782 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 426355005783 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 426355005784 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 426355005785 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 426355005786 tandem repeat interface [polypeptide binding]; other site 426355005787 oligomer interface [polypeptide binding]; other site 426355005788 active site residues [active] 426355005789 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355005790 putative CheW interface [polypeptide binding]; other site 426355005791 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 426355005792 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426355005793 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 426355005794 putative active site pocket [active] 426355005795 cleavage site 426355005796 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 426355005797 NIPSNAP; Region: NIPSNAP; pfam07978 426355005798 NIPSNAP; Region: NIPSNAP; pfam07978 426355005799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355005800 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 426355005801 putative active site [active] 426355005802 heme pocket [chemical binding]; other site 426355005803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355005804 putative active site [active] 426355005805 heme pocket [chemical binding]; other site 426355005806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355005807 dimer interface [polypeptide binding]; other site 426355005808 phosphorylation site [posttranslational modification] 426355005809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355005810 ATP binding site [chemical binding]; other site 426355005811 Mg2+ binding site [ion binding]; other site 426355005812 G-X-G motif; other site 426355005813 Response regulator receiver domain; Region: Response_reg; pfam00072 426355005814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005815 active site 426355005816 phosphorylation site [posttranslational modification] 426355005817 intermolecular recognition site; other site 426355005818 dimerization interface [polypeptide binding]; other site 426355005819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005820 Response regulator receiver domain; Region: Response_reg; pfam00072 426355005821 active site 426355005822 phosphorylation site [posttranslational modification] 426355005823 intermolecular recognition site; other site 426355005824 Predicted permeases [General function prediction only]; Region: RarD; COG2962 426355005825 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 426355005826 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 426355005827 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 426355005828 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426355005829 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355005830 active site 426355005831 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 426355005832 cystathionine beta-lyase; Provisional; Region: PRK05967 426355005833 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426355005834 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426355005835 catalytic residue [active] 426355005836 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 426355005837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005838 active site 426355005839 phosphorylation site [posttranslational modification] 426355005840 intermolecular recognition site; other site 426355005841 dimerization interface [polypeptide binding]; other site 426355005842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355005843 Walker A motif; other site 426355005844 ATP binding site [chemical binding]; other site 426355005845 Walker B motif; other site 426355005846 arginine finger; other site 426355005847 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 426355005848 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 426355005849 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355005850 putative active site [active] 426355005851 heme pocket [chemical binding]; other site 426355005852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355005853 dimer interface [polypeptide binding]; other site 426355005854 phosphorylation site [posttranslational modification] 426355005855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355005856 ATP binding site [chemical binding]; other site 426355005857 Mg2+ binding site [ion binding]; other site 426355005858 G-X-G motif; other site 426355005859 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 426355005860 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 426355005861 FMN binding site [chemical binding]; other site 426355005862 active site 426355005863 catalytic residues [active] 426355005864 substrate binding site [chemical binding]; other site 426355005865 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 426355005866 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 426355005867 substrate binding site; other site 426355005868 dimer interface; other site 426355005869 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 426355005870 homotrimer interaction site [polypeptide binding]; other site 426355005871 zinc binding site [ion binding]; other site 426355005872 CDP-binding sites; other site 426355005873 MAPEG family; Region: MAPEG; cl09190 426355005874 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 426355005875 hypothetical protein; Provisional; Region: PRK06185 426355005876 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 426355005877 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 426355005878 putative coenzyme Q binding site [chemical binding]; other site 426355005879 lipoyl synthase; Provisional; Region: PRK05481 426355005880 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355005881 FeS/SAM binding site; other site 426355005882 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 426355005883 amphipathic channel; other site 426355005884 Asn-Pro-Ala signature motifs; other site 426355005885 glycerol kinase; Provisional; Region: glpK; PRK00047 426355005886 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 426355005887 N- and C-terminal domain interface [polypeptide binding]; other site 426355005888 active site 426355005889 MgATP binding site [chemical binding]; other site 426355005890 catalytic site [active] 426355005891 metal binding site [ion binding]; metal-binding site 426355005892 putative homotetramer interface [polypeptide binding]; other site 426355005893 glycerol binding site [chemical binding]; other site 426355005894 homodimer interface [polypeptide binding]; other site 426355005895 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 426355005896 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 426355005897 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 426355005898 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 426355005899 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 426355005900 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 426355005901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355005902 S-adenosylmethionine binding site [chemical binding]; other site 426355005903 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 426355005904 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355005905 dimerization interface [polypeptide binding]; other site 426355005906 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426355005907 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355005908 dimer interface [polypeptide binding]; other site 426355005909 putative CheW interface [polypeptide binding]; other site 426355005910 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 426355005911 putative binding surface; other site 426355005912 active site 426355005913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355005914 ATP binding site [chemical binding]; other site 426355005915 Mg2+ binding site [ion binding]; other site 426355005916 G-X-G motif; other site 426355005917 CheW-like domain; Region: CheW; pfam01584 426355005918 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355005919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005920 active site 426355005921 phosphorylation site [posttranslational modification] 426355005922 intermolecular recognition site; other site 426355005923 dimerization interface [polypeptide binding]; other site 426355005924 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 426355005925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005926 active site 426355005927 phosphorylation site [posttranslational modification] 426355005928 intermolecular recognition site; other site 426355005929 dimerization interface [polypeptide binding]; other site 426355005930 CheB methylesterase; Region: CheB_methylest; pfam01339 426355005931 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355005932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005933 active site 426355005934 phosphorylation site [posttranslational modification] 426355005935 intermolecular recognition site; other site 426355005936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355005937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355005938 dimer interface [polypeptide binding]; other site 426355005939 phosphorylation site [posttranslational modification] 426355005940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355005941 ATP binding site [chemical binding]; other site 426355005942 Mg2+ binding site [ion binding]; other site 426355005943 G-X-G motif; other site 426355005944 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355005945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005946 active site 426355005947 phosphorylation site [posttranslational modification] 426355005948 intermolecular recognition site; other site 426355005949 dimerization interface [polypeptide binding]; other site 426355005950 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 426355005951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355005952 dimer interface [polypeptide binding]; other site 426355005953 phosphorylation site [posttranslational modification] 426355005954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355005955 ATP binding site [chemical binding]; other site 426355005956 Mg2+ binding site [ion binding]; other site 426355005957 G-X-G motif; other site 426355005958 Response regulator receiver domain; Region: Response_reg; pfam00072 426355005959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355005960 active site 426355005961 phosphorylation site [posttranslational modification] 426355005962 intermolecular recognition site; other site 426355005963 dimerization interface [polypeptide binding]; other site 426355005964 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 426355005965 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 426355005966 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 426355005967 alphaNTD - beta interaction site [polypeptide binding]; other site 426355005968 alphaNTD homodimer interface [polypeptide binding]; other site 426355005969 alphaNTD - beta' interaction site [polypeptide binding]; other site 426355005970 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 426355005971 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 426355005972 30S ribosomal protein S11; Validated; Region: PRK05309 426355005973 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 426355005974 30S ribosomal protein S13; Region: bact_S13; TIGR03631 426355005975 adenylate kinase; Reviewed; Region: adk; PRK00279 426355005976 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 426355005977 AMP-binding site [chemical binding]; other site 426355005978 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 426355005979 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 426355005980 SecY translocase; Region: SecY; pfam00344 426355005981 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 426355005982 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 426355005983 23S rRNA binding site [nucleotide binding]; other site 426355005984 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 426355005985 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 426355005986 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 426355005987 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 426355005988 5S rRNA interface [nucleotide binding]; other site 426355005989 23S rRNA interface [nucleotide binding]; other site 426355005990 L5 interface [polypeptide binding]; other site 426355005991 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 426355005992 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 426355005993 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 426355005994 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 426355005995 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 426355005996 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 426355005997 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 426355005998 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 426355005999 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 426355006000 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 426355006001 RNA binding site [nucleotide binding]; other site 426355006002 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 426355006003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355006004 dimer interface [polypeptide binding]; other site 426355006005 conserved gate region; other site 426355006006 putative PBP binding loops; other site 426355006007 ABC-ATPase subunit interface; other site 426355006008 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 426355006009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355006010 dimer interface [polypeptide binding]; other site 426355006011 conserved gate region; other site 426355006012 putative PBP binding loops; other site 426355006013 ABC-ATPase subunit interface; other site 426355006014 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426355006015 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355006016 substrate binding pocket [chemical binding]; other site 426355006017 membrane-bound complex binding site; other site 426355006018 hinge residues; other site 426355006019 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 426355006020 S17 interaction site [polypeptide binding]; other site 426355006021 S8 interaction site; other site 426355006022 16S rRNA interaction site [nucleotide binding]; other site 426355006023 streptomycin interaction site [chemical binding]; other site 426355006024 23S rRNA interaction site [nucleotide binding]; other site 426355006025 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 426355006026 30S ribosomal protein S7; Validated; Region: PRK05302 426355006027 elongation factor G; Reviewed; Region: PRK00007 426355006028 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 426355006029 G1 box; other site 426355006030 putative GEF interaction site [polypeptide binding]; other site 426355006031 GTP/Mg2+ binding site [chemical binding]; other site 426355006032 Switch I region; other site 426355006033 G2 box; other site 426355006034 G3 box; other site 426355006035 Switch II region; other site 426355006036 G4 box; other site 426355006037 G5 box; other site 426355006038 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 426355006039 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 426355006040 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 426355006041 elongation factor Tu; Reviewed; Region: PRK00049 426355006042 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 426355006043 G1 box; other site 426355006044 GEF interaction site [polypeptide binding]; other site 426355006045 GTP/Mg2+ binding site [chemical binding]; other site 426355006046 Switch I region; other site 426355006047 G2 box; other site 426355006048 G3 box; other site 426355006049 Switch II region; other site 426355006050 G4 box; other site 426355006051 G5 box; other site 426355006052 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 426355006053 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 426355006054 Antibiotic Binding Site [chemical binding]; other site 426355006055 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 426355006056 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 426355006057 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 426355006058 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 426355006059 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 426355006060 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 426355006061 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 426355006062 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 426355006063 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 426355006064 putative translocon binding site; other site 426355006065 protein-rRNA interface [nucleotide binding]; other site 426355006066 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 426355006067 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 426355006068 G-X-X-G motif; other site 426355006069 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 426355006070 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 426355006071 23S rRNA interface [nucleotide binding]; other site 426355006072 5S rRNA interface [nucleotide binding]; other site 426355006073 putative antibiotic binding site [chemical binding]; other site 426355006074 L25 interface [polypeptide binding]; other site 426355006075 L27 interface [polypeptide binding]; other site 426355006076 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 426355006077 23S rRNA interface [nucleotide binding]; other site 426355006078 putative translocon interaction site; other site 426355006079 signal recognition particle (SRP54) interaction site; other site 426355006080 L23 interface [polypeptide binding]; other site 426355006081 trigger factor interaction site; other site 426355006082 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 426355006083 recombinase A; Provisional; Region: recA; PRK09354 426355006084 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 426355006085 hexamer interface [polypeptide binding]; other site 426355006086 Walker A motif; other site 426355006087 ATP binding site [chemical binding]; other site 426355006088 Walker B motif; other site 426355006089 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 426355006090 PAS domain; Region: PAS_8; pfam13188 426355006091 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 426355006092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355006093 dimer interface [polypeptide binding]; other site 426355006094 phosphorylation site [posttranslational modification] 426355006095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355006096 ATP binding site [chemical binding]; other site 426355006097 Mg2+ binding site [ion binding]; other site 426355006098 G-X-G motif; other site 426355006099 Response regulator receiver domain; Region: Response_reg; pfam00072 426355006100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355006101 active site 426355006102 phosphorylation site [posttranslational modification] 426355006103 intermolecular recognition site; other site 426355006104 dimerization interface [polypeptide binding]; other site 426355006105 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 426355006106 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 426355006107 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 426355006108 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 426355006109 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 426355006110 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 426355006111 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 426355006112 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 426355006113 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 426355006114 metabolite-proton symporter; Region: 2A0106; TIGR00883 426355006115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355006116 putative substrate translocation pore; other site 426355006117 DNA polymerase III subunit beta; Validated; Region: PRK05643 426355006118 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 426355006119 putative DNA binding surface [nucleotide binding]; other site 426355006120 dimer interface [polypeptide binding]; other site 426355006121 beta-clamp/clamp loader binding surface; other site 426355006122 beta-clamp/translesion DNA polymerase binding surface; other site 426355006123 recombination protein F; Reviewed; Region: recF; PRK00064 426355006124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355006125 Walker A/P-loop; other site 426355006126 ATP binding site [chemical binding]; other site 426355006127 Q-loop/lid; other site 426355006128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355006129 ABC transporter signature motif; other site 426355006130 Walker B; other site 426355006131 D-loop; other site 426355006132 H-loop/switch region; other site 426355006133 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355006134 dimer interface [polypeptide binding]; other site 426355006135 putative CheW interface [polypeptide binding]; other site 426355006136 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426355006137 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 426355006138 active site 426355006139 dimer interface [polypeptide binding]; other site 426355006140 metal binding site [ion binding]; metal-binding site 426355006141 glutathione binding site [chemical binding]; other site 426355006142 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426355006143 catalytic core [active] 426355006144 High-affinity nickel-transport protein; Region: NicO; cl00964 426355006145 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 426355006146 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 426355006147 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355006148 substrate binding pocket [chemical binding]; other site 426355006149 membrane-bound complex binding site; other site 426355006150 hinge residues; other site 426355006151 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 426355006152 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 426355006153 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426355006154 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426355006155 TM-ABC transporter signature motif; other site 426355006156 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 426355006157 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 426355006158 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426355006159 TM-ABC transporter signature motif; other site 426355006160 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426355006161 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426355006162 Walker A/P-loop; other site 426355006163 ATP binding site [chemical binding]; other site 426355006164 Q-loop/lid; other site 426355006165 ABC transporter signature motif; other site 426355006166 Walker B; other site 426355006167 D-loop; other site 426355006168 H-loop/switch region; other site 426355006169 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426355006170 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426355006171 Walker A/P-loop; other site 426355006172 ATP binding site [chemical binding]; other site 426355006173 Q-loop/lid; other site 426355006174 ABC transporter signature motif; other site 426355006175 Walker B; other site 426355006176 D-loop; other site 426355006177 H-loop/switch region; other site 426355006178 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 426355006179 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 426355006180 dimerization interface [polypeptide binding]; other site 426355006181 ligand binding site [chemical binding]; other site 426355006182 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 426355006183 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355006184 substrate binding pocket [chemical binding]; other site 426355006185 membrane-bound complex binding site; other site 426355006186 hinge residues; other site 426355006187 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 426355006188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355006189 dimer interface [polypeptide binding]; other site 426355006190 conserved gate region; other site 426355006191 putative PBP binding loops; other site 426355006192 ABC-ATPase subunit interface; other site 426355006193 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 426355006194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355006195 dimer interface [polypeptide binding]; other site 426355006196 conserved gate region; other site 426355006197 putative PBP binding loops; other site 426355006198 ABC-ATPase subunit interface; other site 426355006199 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 426355006200 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 426355006201 Walker A/P-loop; other site 426355006202 ATP binding site [chemical binding]; other site 426355006203 Q-loop/lid; other site 426355006204 ABC transporter signature motif; other site 426355006205 Walker B; other site 426355006206 D-loop; other site 426355006207 H-loop/switch region; other site 426355006208 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 426355006209 trimer interface [polypeptide binding]; other site 426355006210 putative metal binding site [ion binding]; other site 426355006211 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 426355006212 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 426355006213 trimer interface [polypeptide binding]; other site 426355006214 putative metal binding site [ion binding]; other site 426355006215 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 426355006216 MoaE homodimer interface [polypeptide binding]; other site 426355006217 MoaD interaction [polypeptide binding]; other site 426355006218 active site residues [active] 426355006219 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 426355006220 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 426355006221 Amidase; Region: Amidase; cl11426 426355006222 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 426355006223 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 426355006224 B1 nucleotide binding pocket [chemical binding]; other site 426355006225 B2 nucleotide binding pocket [chemical binding]; other site 426355006226 CAS motifs; other site 426355006227 active site 426355006228 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 426355006229 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 426355006230 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 426355006231 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 426355006232 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 426355006233 Peptidase family M23; Region: Peptidase_M23; pfam01551 426355006234 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 426355006235 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 426355006236 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426355006237 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 426355006238 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 426355006239 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 426355006240 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 426355006241 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 426355006242 Protein export membrane protein; Region: SecD_SecF; pfam02355 426355006243 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 426355006244 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 426355006245 substrate binding pocket [chemical binding]; other site 426355006246 substrate-Mg2+ binding site; other site 426355006247 aspartate-rich region 2; other site 426355006248 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 426355006249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426355006250 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 426355006251 seryl-tRNA synthetase; Provisional; Region: PRK05431 426355006252 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 426355006253 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 426355006254 dimer interface [polypeptide binding]; other site 426355006255 active site 426355006256 motif 1; other site 426355006257 motif 2; other site 426355006258 motif 3; other site 426355006259 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 426355006260 OsmC-like protein; Region: OsmC; pfam02566 426355006261 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 426355006262 Protein of unknown function (DUF815); Region: DUF815; pfam05673 426355006263 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 426355006264 trimer interface [polypeptide binding]; other site 426355006265 active site 426355006266 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 426355006267 Protein of unknown function (DUF429); Region: DUF429; cl12046 426355006268 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 426355006269 nudix motif; other site 426355006270 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 426355006271 active site clefts [active] 426355006272 zinc binding site [ion binding]; other site 426355006273 dimer interface [polypeptide binding]; other site 426355006274 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 426355006275 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 426355006276 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355006277 Ligand Binding Site [chemical binding]; other site 426355006278 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 426355006279 nucleotide binding site/active site [active] 426355006280 HIT family signature motif; other site 426355006281 catalytic residue [active] 426355006282 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 426355006283 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 426355006284 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 426355006285 putative NADH binding site [chemical binding]; other site 426355006286 putative active site [active] 426355006287 nudix motif; other site 426355006288 putative metal binding site [ion binding]; other site 426355006289 siroheme synthase; Provisional; Region: cysG; PRK10637 426355006290 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 426355006291 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 426355006292 active site 426355006293 SAM binding site [chemical binding]; other site 426355006294 homodimer interface [polypeptide binding]; other site 426355006295 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 426355006296 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 426355006297 [4Fe-4S] binding site [ion binding]; other site 426355006298 molybdopterin cofactor binding site; other site 426355006299 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 426355006300 molybdopterin cofactor binding site; other site 426355006301 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 426355006302 sulfite reductase; Provisional; Region: PRK06214 426355006303 Putative Fe-S cluster; Region: FeS; cl17515 426355006304 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 426355006305 FAD binding pocket [chemical binding]; other site 426355006306 FAD binding motif [chemical binding]; other site 426355006307 catalytic residues [active] 426355006308 NAD binding pocket [chemical binding]; other site 426355006309 phosphate binding motif [ion binding]; other site 426355006310 beta-alpha-beta structure motif; other site 426355006311 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 426355006312 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 426355006313 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 426355006314 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 426355006315 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426355006316 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 426355006317 NMT1-like family; Region: NMT1_2; pfam13379 426355006318 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 426355006319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 426355006320 active site 426355006321 phosphorylation site [posttranslational modification] 426355006322 intermolecular recognition site; other site 426355006323 ANTAR domain; Region: ANTAR; pfam03861 426355006324 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 426355006325 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 426355006326 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 426355006327 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 426355006328 TPP-binding site [chemical binding]; other site 426355006329 dimer interface [polypeptide binding]; other site 426355006330 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 426355006331 PYR/PP interface [polypeptide binding]; other site 426355006332 dimer interface [polypeptide binding]; other site 426355006333 TPP binding site [chemical binding]; other site 426355006334 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 426355006335 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 426355006336 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 426355006337 putative active site [active] 426355006338 catalytic residue [active] 426355006339 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 426355006340 active site 426355006341 dimer interface [polypeptide binding]; other site 426355006342 SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798 426355006343 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 426355006344 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426355006345 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 426355006346 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 426355006347 putative active site [active] 426355006348 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 426355006349 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 426355006350 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426355006351 putative DNA binding site [nucleotide binding]; other site 426355006352 putative Zn2+ binding site [ion binding]; other site 426355006353 AsnC family; Region: AsnC_trans_reg; pfam01037 426355006354 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 426355006355 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 426355006356 trimer interface [polypeptide binding]; other site 426355006357 active site 426355006358 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 426355006359 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 426355006360 acetylornithine deacetylase; Provisional; Region: PRK07522 426355006361 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 426355006362 metal binding site [ion binding]; metal-binding site 426355006363 putative dimer interface [polypeptide binding]; other site 426355006364 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 426355006365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426355006366 Coenzyme A binding pocket [chemical binding]; other site 426355006367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426355006368 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 426355006369 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 426355006370 dimerization interface [polypeptide binding]; other site 426355006371 domain crossover interface; other site 426355006372 redox-dependent activation switch; other site 426355006373 ornithine carbamoyltransferase; Provisional; Region: PRK00779 426355006374 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 426355006375 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 426355006376 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 426355006377 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426355006378 inhibitor-cofactor binding pocket; inhibition site 426355006379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355006380 catalytic residue [active] 426355006381 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 426355006382 homotrimer interaction site [polypeptide binding]; other site 426355006383 putative active site [active] 426355006384 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 426355006385 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 426355006386 active site 426355006387 catalytic site [active] 426355006388 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 426355006389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 426355006390 Protein of unknown function, DUF482; Region: DUF482; pfam04339 426355006391 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 426355006392 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 426355006393 metal binding site [ion binding]; metal-binding site 426355006394 putative dimer interface [polypeptide binding]; other site 426355006395 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 426355006396 putative active site [active] 426355006397 heme pocket [chemical binding]; other site 426355006398 PAS fold; Region: PAS_3; pfam08447 426355006399 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 426355006400 Predicted membrane protein [Function unknown]; Region: COG4655 426355006401 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 426355006402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355006403 Walker A/P-loop; other site 426355006404 ATP binding site [chemical binding]; other site 426355006405 Q-loop/lid; other site 426355006406 ABC transporter signature motif; other site 426355006407 Walker B; other site 426355006408 D-loop; other site 426355006409 H-loop/switch region; other site 426355006410 TOBE domain; Region: TOBE; cl01440 426355006411 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426355006412 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 426355006413 putative C-terminal domain interface [polypeptide binding]; other site 426355006414 putative GSH binding site (G-site) [chemical binding]; other site 426355006415 putative dimer interface [polypeptide binding]; other site 426355006416 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 426355006417 putative N-terminal domain interface [polypeptide binding]; other site 426355006418 putative dimer interface [polypeptide binding]; other site 426355006419 putative substrate binding pocket (H-site) [chemical binding]; other site 426355006420 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 426355006421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355006422 dimer interface [polypeptide binding]; other site 426355006423 conserved gate region; other site 426355006424 putative PBP binding loops; other site 426355006425 ABC-ATPase subunit interface; other site 426355006426 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 426355006427 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 426355006428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355006429 S-adenosylmethionine binding site [chemical binding]; other site 426355006430 Ribosome modulation factor; Region: RMF; cl01207 426355006431 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 426355006432 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 426355006433 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 426355006434 active site 426355006435 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 426355006436 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 426355006437 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 426355006438 DsbD alpha interface [polypeptide binding]; other site 426355006439 catalytic residues [active] 426355006440 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 426355006441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355006442 active site 426355006443 phosphorylation site [posttranslational modification] 426355006444 intermolecular recognition site; other site 426355006445 dimerization interface [polypeptide binding]; other site 426355006446 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355006447 DNA binding site [nucleotide binding] 426355006448 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 426355006449 PhoU domain; Region: PhoU; pfam01895 426355006450 PhoU domain; Region: PhoU; pfam01895 426355006451 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 426355006452 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 426355006453 Walker A/P-loop; other site 426355006454 ATP binding site [chemical binding]; other site 426355006455 Q-loop/lid; other site 426355006456 ABC transporter signature motif; other site 426355006457 Walker B; other site 426355006458 D-loop; other site 426355006459 H-loop/switch region; other site 426355006460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355006461 dimer interface [polypeptide binding]; other site 426355006462 conserved gate region; other site 426355006463 putative PBP binding loops; other site 426355006464 ABC-ATPase subunit interface; other site 426355006465 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 426355006466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355006467 dimer interface [polypeptide binding]; other site 426355006468 conserved gate region; other site 426355006469 putative PBP binding loops; other site 426355006470 ABC-ATPase subunit interface; other site 426355006471 PBP superfamily domain; Region: PBP_like_2; cl17296 426355006472 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 426355006473 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 426355006474 Walker A/P-loop; other site 426355006475 ATP binding site [chemical binding]; other site 426355006476 Q-loop/lid; other site 426355006477 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 426355006478 ABC transporter signature motif; other site 426355006479 Walker B; other site 426355006480 D-loop; other site 426355006481 H-loop/switch region; other site 426355006482 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 426355006483 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 426355006484 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 426355006485 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 426355006486 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 426355006487 nucleotide binding site [chemical binding]; other site 426355006488 SulA interaction site; other site 426355006489 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 426355006490 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 426355006491 Cell division protein FtsA; Region: FtsA; smart00842 426355006492 Cell division protein FtsA; Region: FtsA; pfam14450 426355006493 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 426355006494 Cell division protein FtsQ; Region: FtsQ; pfam03799 426355006495 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 426355006496 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 426355006497 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426355006498 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 426355006499 FAD binding domain; Region: FAD_binding_4; pfam01565 426355006500 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 426355006501 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 426355006502 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 426355006503 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 426355006504 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 426355006505 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 426355006506 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 426355006507 active site 426355006508 homodimer interface [polypeptide binding]; other site 426355006509 cell division protein FtsW; Region: ftsW; TIGR02614 426355006510 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355006511 PAS domain; Region: PAS_9; pfam13426 426355006512 putative active site [active] 426355006513 heme pocket [chemical binding]; other site 426355006514 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355006515 PAS domain; Region: PAS_9; pfam13426 426355006516 putative active site [active] 426355006517 heme pocket [chemical binding]; other site 426355006518 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355006519 dimer interface [polypeptide binding]; other site 426355006520 putative CheW interface [polypeptide binding]; other site 426355006521 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 426355006522 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 426355006523 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 426355006524 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 426355006525 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 426355006526 Mg++ binding site [ion binding]; other site 426355006527 putative catalytic motif [active] 426355006528 putative substrate binding site [chemical binding]; other site 426355006529 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 426355006530 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 426355006531 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 426355006532 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 426355006533 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 426355006534 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 426355006535 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 426355006536 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 426355006537 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 426355006538 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 426355006539 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 426355006540 MraW methylase family; Region: Methyltransf_5; cl17771 426355006541 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 426355006542 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 426355006543 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426355006544 dimer interface [polypeptide binding]; other site 426355006545 active site 426355006546 metal binding site [ion binding]; metal-binding site 426355006547 glutathione binding site [chemical binding]; other site 426355006548 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 426355006549 aminopeptidase N; Provisional; Region: pepN; PRK14015 426355006550 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 426355006551 Zn binding site [ion binding]; other site 426355006552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 426355006553 PAS fold; Region: PAS_3; pfam08447 426355006554 putative active site [active] 426355006555 heme pocket [chemical binding]; other site 426355006556 PAS fold; Region: PAS_7; pfam12860 426355006557 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355006558 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355006559 dimer interface [polypeptide binding]; other site 426355006560 phosphorylation site [posttranslational modification] 426355006561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355006562 ATP binding site [chemical binding]; other site 426355006563 Mg2+ binding site [ion binding]; other site 426355006564 G-X-G motif; other site 426355006565 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 426355006566 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 426355006567 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 426355006568 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 426355006569 oxyanion hole [active] 426355006570 OpgC protein; Region: OpgC_C; pfam10129 426355006571 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 426355006572 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 426355006573 substrate binding site; other site 426355006574 tetramer interface; other site 426355006575 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 426355006576 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 426355006577 NADP binding site [chemical binding]; other site 426355006578 active site 426355006579 putative substrate binding site [chemical binding]; other site 426355006580 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 426355006581 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 426355006582 NAD binding site [chemical binding]; other site 426355006583 substrate binding site [chemical binding]; other site 426355006584 homodimer interface [polypeptide binding]; other site 426355006585 active site 426355006586 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 426355006587 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 426355006588 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355006589 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 426355006590 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 426355006591 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 426355006592 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426355006593 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 426355006594 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 426355006595 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 426355006596 minor groove reading motif; other site 426355006597 helix-hairpin-helix signature motif; other site 426355006598 substrate binding pocket [chemical binding]; other site 426355006599 active site 426355006600 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 426355006601 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 426355006602 regulatory protein interface [polypeptide binding]; other site 426355006603 active site 426355006604 regulatory phosphorylation site [posttranslational modification]; other site 426355006605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 426355006606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 426355006607 Family of unknown function (DUF490); Region: DUF490; pfam04357 426355006608 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 426355006609 Surface antigen; Region: Bac_surface_Ag; pfam01103 426355006610 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 426355006611 Peptidase family M23; Region: Peptidase_M23; pfam01551 426355006612 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 426355006613 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 426355006614 active site 426355006615 HIGH motif; other site 426355006616 nucleotide binding site [chemical binding]; other site 426355006617 active site 426355006618 KMSKS motif; other site 426355006619 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 426355006620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355006621 putative active site [active] 426355006622 heme pocket [chemical binding]; other site 426355006623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355006624 dimer interface [polypeptide binding]; other site 426355006625 phosphorylation site [posttranslational modification] 426355006626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355006627 ATP binding site [chemical binding]; other site 426355006628 Mg2+ binding site [ion binding]; other site 426355006629 G-X-G motif; other site 426355006630 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355006631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355006632 active site 426355006633 phosphorylation site [posttranslational modification] 426355006634 intermolecular recognition site; other site 426355006635 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 426355006636 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426355006637 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 426355006638 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355006639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355006640 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 426355006641 putative substrate binding pocket [chemical binding]; other site 426355006642 putative dimerization interface [polypeptide binding]; other site 426355006643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 426355006644 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 426355006645 acetolactate synthase; Reviewed; Region: PRK08322 426355006646 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426355006647 PYR/PP interface [polypeptide binding]; other site 426355006648 dimer interface [polypeptide binding]; other site 426355006649 TPP binding site [chemical binding]; other site 426355006650 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426355006651 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 426355006652 TPP-binding site [chemical binding]; other site 426355006653 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 426355006654 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 426355006655 putative active site [active] 426355006656 metal binding site [ion binding]; metal-binding site 426355006657 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 426355006658 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 426355006659 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 426355006660 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 426355006661 Coenzyme A transferase; Region: CoA_trans; smart00882 426355006662 Coenzyme A transferase; Region: CoA_trans; cl17247 426355006663 succinic semialdehyde dehydrogenase; Region: PLN02278 426355006664 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 426355006665 tetramerization interface [polypeptide binding]; other site 426355006666 NAD(P) binding site [chemical binding]; other site 426355006667 catalytic residues [active] 426355006668 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 426355006669 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355006670 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355006671 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 426355006672 Fusaric acid resistance protein family; Region: FUSC; pfam04632 426355006673 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 426355006674 Fusaric acid resistance protein family; Region: FUSC; pfam04632 426355006675 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426355006676 MarR family; Region: MarR_2; pfam12802 426355006677 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426355006678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355006679 active site 426355006680 phosphorylation site [posttranslational modification] 426355006681 intermolecular recognition site; other site 426355006682 dimerization interface [polypeptide binding]; other site 426355006683 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355006684 DNA binding residues [nucleotide binding] 426355006685 dimerization interface [polypeptide binding]; other site 426355006686 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 426355006687 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 426355006688 dimer interface [polypeptide binding]; other site 426355006689 Trp docking motif [polypeptide binding]; other site 426355006690 active site 426355006691 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426355006692 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355006693 substrate binding pocket [chemical binding]; other site 426355006694 membrane-bound complex binding site; other site 426355006695 hinge residues; other site 426355006696 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 426355006697 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 426355006698 ligand binding site [chemical binding]; other site 426355006699 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426355006700 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 426355006701 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426355006702 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426355006703 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426355006704 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426355006705 FMN-binding domain; Region: FMN_bind; cl01081 426355006706 4Fe-4S binding domain; Region: Fer4_5; pfam12801 426355006707 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 426355006708 ApbE family; Region: ApbE; pfam02424 426355006709 Beta-lactamase; Region: Beta-lactamase; pfam00144 426355006710 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 426355006711 glutamate carboxypeptidase; Reviewed; Region: PRK06133 426355006712 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 426355006713 metal binding site [ion binding]; metal-binding site 426355006714 dimer interface [polypeptide binding]; other site 426355006715 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 426355006716 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 426355006717 glutaminase active site [active] 426355006718 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 426355006719 dimer interface [polypeptide binding]; other site 426355006720 active site 426355006721 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 426355006722 dimer interface [polypeptide binding]; other site 426355006723 active site 426355006724 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 426355006725 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 426355006726 Substrate binding site; other site 426355006727 Mg++ binding site; other site 426355006728 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 426355006729 active site 426355006730 substrate binding site [chemical binding]; other site 426355006731 CoA binding site [chemical binding]; other site 426355006732 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 426355006733 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 426355006734 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 426355006735 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 426355006736 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355006737 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 426355006738 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 426355006739 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 426355006740 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 426355006741 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 426355006742 Cu(I) binding site [ion binding]; other site 426355006743 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426355006744 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355006745 metal binding site [ion binding]; metal-binding site 426355006746 active site 426355006747 I-site; other site 426355006748 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355006749 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426355006750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355006751 non-specific DNA binding site [nucleotide binding]; other site 426355006752 salt bridge; other site 426355006753 sequence-specific DNA binding site [nucleotide binding]; other site 426355006754 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 426355006755 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 426355006756 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 426355006757 metal binding site [ion binding]; metal-binding site 426355006758 dimer interface [polypeptide binding]; other site 426355006759 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355006760 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355006761 ligand binding site [chemical binding]; other site 426355006762 flexible hinge region; other site 426355006763 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 426355006764 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 426355006765 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355006766 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 426355006767 active site residue [active] 426355006768 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426355006769 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426355006770 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355006771 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 426355006772 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 426355006773 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 426355006774 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 426355006775 putative acyl-acceptor binding pocket; other site 426355006776 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 426355006777 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 426355006778 active site 426355006779 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 426355006780 IHF dimer interface [polypeptide binding]; other site 426355006781 IHF - DNA interface [nucleotide binding]; other site 426355006782 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 426355006783 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 426355006784 tandem repeat interface [polypeptide binding]; other site 426355006785 oligomer interface [polypeptide binding]; other site 426355006786 active site residues [active] 426355006787 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 426355006788 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 426355006789 RNA binding site [nucleotide binding]; other site 426355006790 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 426355006791 RNA binding site [nucleotide binding]; other site 426355006792 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 426355006793 RNA binding site [nucleotide binding]; other site 426355006794 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 426355006795 RNA binding site [nucleotide binding]; other site 426355006796 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 426355006797 RNA binding site [nucleotide binding]; other site 426355006798 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 426355006799 RNA binding site [nucleotide binding]; other site 426355006800 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355006801 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355006802 ligand binding site [chemical binding]; other site 426355006803 flexible hinge region; other site 426355006804 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 426355006805 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 426355006806 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 426355006807 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 426355006808 ligand binding site [chemical binding]; other site 426355006809 NAD binding site [chemical binding]; other site 426355006810 tetramer interface [polypeptide binding]; other site 426355006811 catalytic site [active] 426355006812 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 426355006813 L-serine binding site [chemical binding]; other site 426355006814 ACT domain interface; other site 426355006815 Predicted flavoprotein [General function prediction only]; Region: COG0431 426355006816 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 426355006817 short chain dehydrogenase; Provisional; Region: PRK06701 426355006818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355006819 NAD(P) binding site [chemical binding]; other site 426355006820 active site 426355006821 BA14K-like protein; Region: BA14K; pfam07886 426355006822 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 426355006823 dimerization interface [polypeptide binding]; other site 426355006824 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355006825 dimer interface [polypeptide binding]; other site 426355006826 putative CheW interface [polypeptide binding]; other site 426355006827 UreD urease accessory protein; Region: UreD; cl00530 426355006828 agmatinase; Region: agmatinase; TIGR01230 426355006829 Arginase family; Region: Arginase; cd09989 426355006830 active site 426355006831 Mn binding site [ion binding]; other site 426355006832 oligomer interface [polypeptide binding]; other site 426355006833 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426355006834 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355006835 dimer interface [polypeptide binding]; other site 426355006836 putative CheW interface [polypeptide binding]; other site 426355006837 HAMP domain; Region: HAMP; pfam00672 426355006838 dimerization interface [polypeptide binding]; other site 426355006839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355006840 dimer interface [polypeptide binding]; other site 426355006841 phosphorylation site [posttranslational modification] 426355006842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355006843 ATP binding site [chemical binding]; other site 426355006844 Mg2+ binding site [ion binding]; other site 426355006845 G-X-G motif; other site 426355006846 osmolarity response regulator; Provisional; Region: ompR; PRK09468 426355006847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355006848 active site 426355006849 phosphorylation site [posttranslational modification] 426355006850 intermolecular recognition site; other site 426355006851 dimerization interface [polypeptide binding]; other site 426355006852 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355006853 DNA binding site [nucleotide binding] 426355006854 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426355006855 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426355006856 active site 426355006857 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 426355006858 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 426355006859 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 426355006860 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 426355006861 [2Fe-2S] cluster binding site [ion binding]; other site 426355006862 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 426355006863 putative alpha subunit interface [polypeptide binding]; other site 426355006864 putative active site [active] 426355006865 putative substrate binding site [chemical binding]; other site 426355006866 Fe binding site [ion binding]; other site 426355006867 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 426355006868 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 426355006869 FAD binding pocket [chemical binding]; other site 426355006870 FAD binding motif [chemical binding]; other site 426355006871 phosphate binding motif [ion binding]; other site 426355006872 beta-alpha-beta structure motif; other site 426355006873 NAD binding pocket [chemical binding]; other site 426355006874 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355006875 catalytic loop [active] 426355006876 iron binding site [ion binding]; other site 426355006877 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 426355006878 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 426355006879 putative active site [active] 426355006880 putative FMN binding site [chemical binding]; other site 426355006881 putative substrate binding site [chemical binding]; other site 426355006882 putative catalytic residue [active] 426355006883 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426355006884 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 426355006885 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 426355006886 4Fe-4S binding domain; Region: Fer4; cl02805 426355006887 Cysteine-rich domain; Region: CCG; pfam02754 426355006888 Cysteine-rich domain; Region: CCG; pfam02754 426355006889 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 426355006890 Electron transfer flavoprotein domain; Region: ETF; smart00893 426355006891 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 426355006892 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 426355006893 putative deacylase active site [active] 426355006894 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 426355006895 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 426355006896 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 426355006897 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 426355006898 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 426355006899 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 426355006900 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426355006901 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 426355006902 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 426355006903 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 426355006904 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 426355006905 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426355006906 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 426355006907 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 426355006908 conserved cys residue [active] 426355006909 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355006910 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 426355006911 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 426355006912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355006913 dimer interface [polypeptide binding]; other site 426355006914 conserved gate region; other site 426355006915 putative PBP binding loops; other site 426355006916 ABC-ATPase subunit interface; other site 426355006917 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 426355006918 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355006919 Walker A/P-loop; other site 426355006920 ATP binding site [chemical binding]; other site 426355006921 Q-loop/lid; other site 426355006922 ABC transporter signature motif; other site 426355006923 Walker B; other site 426355006924 D-loop; other site 426355006925 H-loop/switch region; other site 426355006926 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 426355006927 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 426355006928 putative active site [active] 426355006929 putative metal binding residues [ion binding]; other site 426355006930 signature motif; other site 426355006931 putative dimer interface [polypeptide binding]; other site 426355006932 putative phosphate binding site [ion binding]; other site 426355006933 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 426355006934 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 426355006935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355006936 Response regulator receiver domain; Region: Response_reg; pfam00072 426355006937 active site 426355006938 phosphorylation site [posttranslational modification] 426355006939 intermolecular recognition site; other site 426355006940 dimerization interface [polypeptide binding]; other site 426355006941 flagellin; Reviewed; Region: PRK12688 426355006942 flagellin; Reviewed; Region: PRK12688 426355006943 flagellin; Reviewed; Region: PRK12688 426355006944 flagellin; Reviewed; Region: PRK12688 426355006945 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426355006946 DNA binding site [nucleotide binding] 426355006947 Int/Topo IB signature motif; other site 426355006948 active site 426355006949 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 426355006950 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426355006951 putative active site [active] 426355006952 putative metal binding site [ion binding]; other site 426355006953 Fic family protein [Function unknown]; Region: COG3177 426355006954 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 426355006955 Fic/DOC family; Region: Fic; pfam02661 426355006956 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 426355006957 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 426355006958 putative metal binding site [ion binding]; other site 426355006959 putative homodimer interface [polypeptide binding]; other site 426355006960 putative homotetramer interface [polypeptide binding]; other site 426355006961 putative homodimer-homodimer interface [polypeptide binding]; other site 426355006962 putative allosteric switch controlling residues; other site 426355006963 High-affinity nickel-transport protein; Region: NicO; cl00964 426355006964 High-affinity nickel-transport protein; Region: NicO; cl00964 426355006965 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 426355006966 metal-binding site [ion binding] 426355006967 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 426355006968 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355006969 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 426355006970 Protein export membrane protein; Region: SecD_SecF; cl14618 426355006971 Domain of unknown function (DUF305); Region: DUF305; cl17794 426355006972 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 426355006973 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 426355006974 DNA binding residues [nucleotide binding] 426355006975 dimer interface [polypeptide binding]; other site 426355006976 copper binding site [ion binding]; other site 426355006977 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 426355006978 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 426355006979 PAS domain; Region: PAS_9; pfam13426 426355006980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355006981 putative active site [active] 426355006982 heme pocket [chemical binding]; other site 426355006983 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355006984 PAS domain; Region: PAS_9; pfam13426 426355006985 putative active site [active] 426355006986 heme pocket [chemical binding]; other site 426355006987 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355006988 PAS domain; Region: PAS_9; pfam13426 426355006989 putative active site [active] 426355006990 heme pocket [chemical binding]; other site 426355006991 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426355006992 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355006993 dimer interface [polypeptide binding]; other site 426355006994 putative CheW interface [polypeptide binding]; other site 426355006995 PilZ domain; Region: PilZ; pfam07238 426355006996 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 426355006997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355006998 DNA-binding site [nucleotide binding]; DNA binding site 426355006999 FCD domain; Region: FCD; pfam07729 426355007000 L-lactate permease; Region: Lactate_perm; cl00701 426355007001 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 426355007002 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 426355007003 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 426355007004 phosphate binding site [ion binding]; other site 426355007005 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355007006 dimerization interface [polypeptide binding]; other site 426355007007 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355007008 dimer interface [polypeptide binding]; other site 426355007009 putative CheW interface [polypeptide binding]; other site 426355007010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355007011 Radical SAM superfamily; Region: Radical_SAM; pfam04055 426355007012 FeS/SAM binding site; other site 426355007013 mercuric reductase; Validated; Region: PRK06370 426355007014 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426355007015 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426355007016 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 426355007017 Methyltransferase domain; Region: Methyltransf_31; pfam13847 426355007018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355007019 S-adenosylmethionine binding site [chemical binding]; other site 426355007020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355007021 NAD(P) binding site [chemical binding]; other site 426355007022 active site 426355007023 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 426355007024 Probable Catalytic site; other site 426355007025 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 426355007026 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 426355007027 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 426355007028 Domain of unknown function DUF302; Region: DUF302; pfam03625 426355007029 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 426355007030 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 426355007031 putative catalytic residues [active] 426355007032 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 426355007033 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 426355007034 catalytic residues [active] 426355007035 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 426355007036 active site 426355007037 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 426355007038 RNA polymerase sigma factor; Provisional; Region: PRK12539 426355007039 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355007040 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426355007041 DNA binding residues [nucleotide binding] 426355007042 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 426355007043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426355007044 motif II; other site 426355007045 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 426355007046 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 426355007047 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355007048 Ligand Binding Site [chemical binding]; other site 426355007049 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355007050 Ligand Binding Site [chemical binding]; other site 426355007051 Cytochrome c; Region: Cytochrom_C; pfam00034 426355007052 Sensors of blue-light using FAD; Region: BLUF; pfam04940 426355007053 putative transposase OrfB; Reviewed; Region: PHA02517 426355007054 HTH-like domain; Region: HTH_21; pfam13276 426355007055 Integrase core domain; Region: rve; pfam00665 426355007056 Integrase core domain; Region: rve_2; pfam13333 426355007057 Transposase; Region: HTH_Tnp_1; cl17663 426355007058 NnrS protein; Region: NnrS; pfam05940 426355007059 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 426355007060 NnrU protein; Region: NnrU; pfam07298 426355007061 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355007062 PAS fold; Region: PAS_3; pfam08447 426355007063 putative active site [active] 426355007064 heme pocket [chemical binding]; other site 426355007065 PAS domain S-box; Region: sensory_box; TIGR00229 426355007066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355007067 putative active site [active] 426355007068 heme pocket [chemical binding]; other site 426355007069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355007070 dimer interface [polypeptide binding]; other site 426355007071 phosphorylation site [posttranslational modification] 426355007072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355007073 ATP binding site [chemical binding]; other site 426355007074 Mg2+ binding site [ion binding]; other site 426355007075 G-X-G motif; other site 426355007076 response regulator FixJ; Provisional; Region: fixJ; PRK09390 426355007077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355007078 active site 426355007079 phosphorylation site [posttranslational modification] 426355007080 intermolecular recognition site; other site 426355007081 dimerization interface [polypeptide binding]; other site 426355007082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355007083 DNA binding residues [nucleotide binding] 426355007084 dimerization interface [polypeptide binding]; other site 426355007085 Response regulator receiver domain; Region: Response_reg; pfam00072 426355007086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355007087 active site 426355007088 phosphorylation site [posttranslational modification] 426355007089 intermolecular recognition site; other site 426355007090 dimerization interface [polypeptide binding]; other site 426355007091 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 426355007092 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355007093 ligand binding site [chemical binding]; other site 426355007094 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426355007095 putative switch regulator; other site 426355007096 non-specific DNA interactions [nucleotide binding]; other site 426355007097 DNA binding site [nucleotide binding] 426355007098 sequence specific DNA binding site [nucleotide binding]; other site 426355007099 putative cAMP binding site [chemical binding]; other site 426355007100 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 426355007101 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 426355007102 dimer interface [polypeptide binding]; other site 426355007103 putative functional site; other site 426355007104 putative MPT binding site; other site 426355007105 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 426355007106 MPT binding site; other site 426355007107 trimer interface [polypeptide binding]; other site 426355007108 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 426355007109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355007110 FeS/SAM binding site; other site 426355007111 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 426355007112 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 426355007113 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 426355007114 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 426355007115 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 426355007116 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 426355007117 4Fe-4S binding domain; Region: Fer4; cl02805 426355007118 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 426355007119 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 426355007120 [4Fe-4S] binding site [ion binding]; other site 426355007121 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426355007122 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426355007123 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426355007124 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 426355007125 molybdopterin cofactor binding site; other site 426355007126 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 426355007127 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 426355007128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355007129 putative substrate translocation pore; other site 426355007130 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355007131 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355007132 ligand binding site [chemical binding]; other site 426355007133 flexible hinge region; other site 426355007134 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426355007135 putative switch regulator; other site 426355007136 non-specific DNA interactions [nucleotide binding]; other site 426355007137 DNA binding site [nucleotide binding] 426355007138 sequence specific DNA binding site [nucleotide binding]; other site 426355007139 putative cAMP binding site [chemical binding]; other site 426355007140 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 426355007141 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 426355007142 heme-binding site [chemical binding]; other site 426355007143 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 426355007144 FAD binding pocket [chemical binding]; other site 426355007145 FAD binding motif [chemical binding]; other site 426355007146 phosphate binding motif [ion binding]; other site 426355007147 beta-alpha-beta structure motif; other site 426355007148 NAD binding pocket [chemical binding]; other site 426355007149 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355007150 putative active site [active] 426355007151 PAS fold; Region: PAS_3; pfam08447 426355007152 heme pocket [chemical binding]; other site 426355007153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355007154 non-specific DNA binding site [nucleotide binding]; other site 426355007155 salt bridge; other site 426355007156 sequence-specific DNA binding site [nucleotide binding]; other site 426355007157 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355007158 Ligand Binding Site [chemical binding]; other site 426355007159 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 426355007160 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 426355007161 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 426355007162 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 426355007163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426355007164 motif II; other site 426355007165 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 426355007166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 426355007167 Predicted kinase [General function prediction only]; Region: COG0645 426355007168 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 426355007169 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 426355007170 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 426355007171 Soluble P-type ATPase [General function prediction only]; Region: COG4087 426355007172 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 426355007173 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 426355007174 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 426355007175 BON domain; Region: BON; pfam04972 426355007176 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355007177 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355007178 ligand binding site [chemical binding]; other site 426355007179 flexible hinge region; other site 426355007180 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 426355007181 non-specific DNA interactions [nucleotide binding]; other site 426355007182 DNA binding site [nucleotide binding] 426355007183 sequence specific DNA binding site [nucleotide binding]; other site 426355007184 putative cAMP binding site [chemical binding]; other site 426355007185 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 426355007186 propionate/acetate kinase; Provisional; Region: PRK12379 426355007187 putative phosphoketolase; Provisional; Region: PRK05261 426355007188 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 426355007189 TPP-binding site; other site 426355007190 XFP C-terminal domain; Region: XFP_C; pfam09363 426355007191 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 426355007192 BON domain; Region: BON; cl02771 426355007193 BON domain; Region: BON; pfam04972 426355007194 BON domain; Region: BON; pfam04972 426355007195 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 426355007196 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 426355007197 putative NAD(P) binding site [chemical binding]; other site 426355007198 putative substrate binding site [chemical binding]; other site 426355007199 catalytic Zn binding site [ion binding]; other site 426355007200 structural Zn binding site [ion binding]; other site 426355007201 Transposase, Mutator family; Region: Transposase_mut; pfam00872 426355007202 MULE transposase domain; Region: MULE; pfam10551 426355007203 Universal stress protein family; Region: Usp; pfam00582 426355007204 Ligand Binding Site [chemical binding]; other site 426355007205 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355007206 Ligand Binding Site [chemical binding]; other site 426355007207 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 426355007208 Cytochrome c; Region: Cytochrom_C; pfam00034 426355007209 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355007210 Ligand Binding Site [chemical binding]; other site 426355007211 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355007212 Ligand Binding Site [chemical binding]; other site 426355007213 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 426355007214 BON domain; Region: BON; pfam04972 426355007215 BON domain; Region: BON; pfam04972 426355007216 BON domain; Region: BON; pfam04972 426355007217 response regulator; Provisional; Region: PRK13435 426355007218 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 426355007219 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 426355007220 Ion channel; Region: Ion_trans_2; pfam07885 426355007221 SPW repeat; Region: SPW; pfam03779 426355007222 Cytochrome c; Region: Cytochrom_C; cl11414 426355007223 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355007224 Ligand Binding Site [chemical binding]; other site 426355007225 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 426355007226 Ligand Binding Site [chemical binding]; other site 426355007227 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 426355007228 HTH-like domain; Region: HTH_21; pfam13276 426355007229 Integrase core domain; Region: rve; pfam00665 426355007230 Integrase core domain; Region: rve_3; pfam13683 426355007231 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 426355007232 DNA-binding interface [nucleotide binding]; DNA binding site 426355007233 Winged helix-turn helix; Region: HTH_29; pfam13551 426355007234 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 426355007235 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 426355007236 catalytic residue [active] 426355007237 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 426355007238 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 426355007239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 426355007240 Walker A motif; other site 426355007241 ATP binding site [chemical binding]; other site 426355007242 Walker B motif; other site 426355007243 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 426355007244 Abortive infection C-terminus; Region: Abi_C; pfam14355 426355007245 2-isopropylmalate synthase; Validated; Region: PRK00915 426355007246 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 426355007247 active site 426355007248 catalytic residues [active] 426355007249 metal binding site [ion binding]; metal-binding site 426355007250 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 426355007251 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 426355007252 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 426355007253 active site clefts [active] 426355007254 zinc binding site [ion binding]; other site 426355007255 dimer interface [polypeptide binding]; other site 426355007256 tartrate dehydrogenase; Region: TTC; TIGR02089 426355007257 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 426355007258 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 426355007259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355007260 S-adenosylmethionine binding site [chemical binding]; other site 426355007261 ABC1 family; Region: ABC1; cl17513 426355007262 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 426355007263 CHASE3 domain; Region: CHASE3; pfam05227 426355007264 PAS fold; Region: PAS_4; pfam08448 426355007265 PAS domain; Region: PAS_9; pfam13426 426355007266 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355007267 putative active site [active] 426355007268 heme pocket [chemical binding]; other site 426355007269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355007270 dimer interface [polypeptide binding]; other site 426355007271 phosphorylation site [posttranslational modification] 426355007272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355007273 ATP binding site [chemical binding]; other site 426355007274 Mg2+ binding site [ion binding]; other site 426355007275 G-X-G motif; other site 426355007276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355007277 active site 426355007278 phosphorylation site [posttranslational modification] 426355007279 intermolecular recognition site; other site 426355007280 dimerization interface [polypeptide binding]; other site 426355007281 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355007282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355007283 active site 426355007284 phosphorylation site [posttranslational modification] 426355007285 intermolecular recognition site; other site 426355007286 dimerization interface [polypeptide binding]; other site 426355007287 Predicted ATPase [General function prediction only]; Region: COG1485 426355007288 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 426355007289 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 426355007290 Coenzyme A binding pocket [chemical binding]; other site 426355007291 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 426355007292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355007293 Domain of unknown function (DUF427); Region: DUF427; pfam04248 426355007294 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 426355007295 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 426355007296 NAD binding site [chemical binding]; other site 426355007297 homotetramer interface [polypeptide binding]; other site 426355007298 homodimer interface [polypeptide binding]; other site 426355007299 substrate binding site [chemical binding]; other site 426355007300 active site 426355007301 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 426355007302 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 426355007303 dimer interface [polypeptide binding]; other site 426355007304 active site 426355007305 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 426355007306 active site 1 [active] 426355007307 dimer interface [polypeptide binding]; other site 426355007308 active site 2 [active] 426355007309 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 426355007310 metal binding site 2 [ion binding]; metal-binding site 426355007311 putative DNA binding helix; other site 426355007312 metal binding site 1 [ion binding]; metal-binding site 426355007313 dimer interface [polypeptide binding]; other site 426355007314 structural Zn2+ binding site [ion binding]; other site 426355007315 Bacterial SH3 domain; Region: SH3_4; pfam06347 426355007316 Bacterial SH3 domain; Region: SH3_4; pfam06347 426355007317 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 426355007318 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 426355007319 dimerization interface [polypeptide binding]; other site 426355007320 ligand binding site [chemical binding]; other site 426355007321 NADP binding site [chemical binding]; other site 426355007322 catalytic site [active] 426355007323 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355007324 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355007325 ligand binding site [chemical binding]; other site 426355007326 flexible hinge region; other site 426355007327 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 426355007328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426355007329 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426355007330 CysZ-like protein; Reviewed; Region: PRK12768 426355007331 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426355007332 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355007333 HAMP domain; Region: HAMP; pfam00672 426355007334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355007335 PAS fold; Region: PAS_7; pfam12860 426355007336 putative active site [active] 426355007337 heme pocket [chemical binding]; other site 426355007338 PAS domain; Region: PAS; smart00091 426355007339 PAS fold; Region: PAS_7; pfam12860 426355007340 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355007341 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355007342 metal binding site [ion binding]; metal-binding site 426355007343 active site 426355007344 I-site; other site 426355007345 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355007346 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 426355007347 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 426355007348 glutathione reductase; Validated; Region: PRK06116 426355007349 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426355007350 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 426355007351 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 426355007352 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 426355007353 tetramer (dimer of dimers) interface [polypeptide binding]; other site 426355007354 active site 426355007355 dimer interface [polypeptide binding]; other site 426355007356 phosphoglycolate phosphatase; Provisional; Region: PRK13222 426355007357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426355007358 motif II; other site 426355007359 hypothetical protein; Provisional; Region: PRK08960 426355007360 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426355007361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355007362 homodimer interface [polypeptide binding]; other site 426355007363 catalytic residue [active] 426355007364 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 426355007365 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 426355007366 catalytic residues [active] 426355007367 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 426355007368 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 426355007369 carboxyltransferase (CT) interaction site; other site 426355007370 biotinylation site [posttranslational modification]; other site 426355007371 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 426355007372 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 426355007373 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426355007374 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 426355007375 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 426355007376 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 426355007377 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 426355007378 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 426355007379 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 426355007380 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355007381 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 426355007382 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 426355007383 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 426355007384 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 426355007385 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 426355007386 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 426355007387 ABC-2 type transporter; Region: ABC2_membrane; cl17235 426355007388 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 426355007389 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 426355007390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355007391 Walker A/P-loop; other site 426355007392 ATP binding site [chemical binding]; other site 426355007393 Q-loop/lid; other site 426355007394 ABC transporter signature motif; other site 426355007395 Walker B; other site 426355007396 D-loop; other site 426355007397 H-loop/switch region; other site 426355007398 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 426355007399 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426355007400 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426355007401 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426355007402 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426355007403 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 426355007404 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355007405 ligand binding site [chemical binding]; other site 426355007406 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 426355007407 hypothetical protein; Provisional; Region: PRK02227 426355007408 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 426355007409 nucleotide binding site [chemical binding]; other site 426355007410 substrate binding site [chemical binding]; other site 426355007411 dihydropteroate synthase-related protein; Region: TIGR00284 426355007412 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 426355007413 substrate binding pocket [chemical binding]; other site 426355007414 dimer interface [polypeptide binding]; other site 426355007415 inhibitor binding site; inhibition site 426355007416 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 426355007417 Protein of unknown function (DUF447); Region: DUF447; pfam04289 426355007418 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 426355007419 putative hydrophobic ligand binding site [chemical binding]; other site 426355007420 protein interface [polypeptide binding]; other site 426355007421 gate; other site 426355007422 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 426355007423 NHL repeat; Region: NHL; pfam01436 426355007424 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426355007425 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426355007426 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426355007427 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 426355007428 Response regulator receiver domain; Region: Response_reg; pfam00072 426355007429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355007430 active site 426355007431 phosphorylation site [posttranslational modification] 426355007432 intermolecular recognition site; other site 426355007433 dimerization interface [polypeptide binding]; other site 426355007434 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 426355007435 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 426355007436 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 426355007437 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 426355007438 DNA-binding site [nucleotide binding]; DNA binding site 426355007439 RNA-binding motif; other site 426355007440 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 426355007441 DNA-binding site [nucleotide binding]; DNA binding site 426355007442 RNA-binding motif; other site 426355007443 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 426355007444 elongation factor P; Validated; Region: PRK00529 426355007445 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 426355007446 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 426355007447 RNA binding site [nucleotide binding]; other site 426355007448 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 426355007449 RNA binding site [nucleotide binding]; other site 426355007450 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 426355007451 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 426355007452 motif 1; other site 426355007453 dimer interface [polypeptide binding]; other site 426355007454 active site 426355007455 motif 2; other site 426355007456 motif 3; other site 426355007457 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 426355007458 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355007459 FeS/SAM binding site; other site 426355007460 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 426355007461 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 426355007462 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426355007463 putative C-terminal domain interface [polypeptide binding]; other site 426355007464 putative GSH binding site (G-site) [chemical binding]; other site 426355007465 putative dimer interface [polypeptide binding]; other site 426355007466 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 426355007467 putative N-terminal domain interface [polypeptide binding]; other site 426355007468 putative dimer interface [polypeptide binding]; other site 426355007469 putative substrate binding pocket (H-site) [chemical binding]; other site 426355007470 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 426355007471 Uncharacterized conserved protein [Function unknown]; Region: COG1434 426355007472 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 426355007473 putative active site [active] 426355007474 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 426355007475 Protein of unknown function, DUF599; Region: DUF599; pfam04654 426355007476 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 426355007477 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 426355007478 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 426355007479 putative active site pocket [active] 426355007480 dimerization interface [polypeptide binding]; other site 426355007481 putative catalytic residue [active] 426355007482 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 426355007483 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 426355007484 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 426355007485 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 426355007486 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 426355007487 carboxyltransferase (CT) interaction site; other site 426355007488 biotinylation site [posttranslational modification]; other site 426355007489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426355007490 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426355007491 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 426355007492 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 426355007493 putative active site [active] 426355007494 Zn binding site [ion binding]; other site 426355007495 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 426355007496 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 426355007497 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 426355007498 dimerization interface [polypeptide binding]; other site 426355007499 active site 426355007500 Fic/DOC family; Region: Fic; cl00960 426355007501 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 426355007502 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 426355007503 Tetramer interface [polypeptide binding]; other site 426355007504 active site 426355007505 FMN-binding site [chemical binding]; other site 426355007506 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 426355007507 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 426355007508 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 426355007509 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 426355007510 active site 426355007511 HIGH motif; other site 426355007512 dimer interface [polypeptide binding]; other site 426355007513 KMSKS motif; other site 426355007514 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426355007515 RNA binding surface [nucleotide binding]; other site 426355007516 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355007517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355007518 active site 426355007519 phosphorylation site [posttranslational modification] 426355007520 intermolecular recognition site; other site 426355007521 dimerization interface [polypeptide binding]; other site 426355007522 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355007523 DNA binding site [nucleotide binding] 426355007524 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 426355007525 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 426355007526 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 426355007527 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 426355007528 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 426355007529 Sporulation related domain; Region: SPOR; pfam05036 426355007530 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 426355007531 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 426355007532 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 426355007533 active site 426355007534 HIGH motif; other site 426355007535 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 426355007536 KMSK motif region; other site 426355007537 tRNA binding surface [nucleotide binding]; other site 426355007538 DALR anticodon binding domain; Region: DALR_1; smart00836 426355007539 anticodon binding site; other site 426355007540 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 426355007541 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 426355007542 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 426355007543 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 426355007544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355007545 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426355007546 putative substrate translocation pore; other site 426355007547 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 426355007548 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 426355007549 tetramer interface [polypeptide binding]; other site 426355007550 active site 426355007551 Mg2+/Mn2+ binding site [ion binding]; other site 426355007552 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 426355007553 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355007554 Walker A/P-loop; other site 426355007555 ATP binding site [chemical binding]; other site 426355007556 Q-loop/lid; other site 426355007557 ABC transporter signature motif; other site 426355007558 Walker B; other site 426355007559 D-loop; other site 426355007560 H-loop/switch region; other site 426355007561 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426355007562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355007563 dimer interface [polypeptide binding]; other site 426355007564 conserved gate region; other site 426355007565 putative PBP binding loops; other site 426355007566 ABC-ATPase subunit interface; other site 426355007567 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355007568 membrane-bound complex binding site; other site 426355007569 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 426355007570 aromatic arch; other site 426355007571 DCoH dimer interaction site [polypeptide binding]; other site 426355007572 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 426355007573 DCoH tetramer interaction site [polypeptide binding]; other site 426355007574 substrate binding site [chemical binding]; other site 426355007575 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 426355007576 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426355007577 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355007578 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426355007579 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355007580 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355007581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426355007582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355007583 Response regulator receiver domain; Region: Response_reg; pfam00072 426355007584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355007585 active site 426355007586 phosphorylation site [posttranslational modification] 426355007587 intermolecular recognition site; other site 426355007588 dimerization interface [polypeptide binding]; other site 426355007589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355007590 Histidine kinase; Region: HisKA_2; pfam07568 426355007591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355007592 ATP binding site [chemical binding]; other site 426355007593 Mg2+ binding site [ion binding]; other site 426355007594 G-X-G motif; other site 426355007595 Response regulator receiver domain; Region: Response_reg; pfam00072 426355007596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355007597 active site 426355007598 phosphorylation site [posttranslational modification] 426355007599 intermolecular recognition site; other site 426355007600 dimerization interface [polypeptide binding]; other site 426355007601 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 426355007602 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 426355007603 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 426355007604 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 426355007605 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355007606 putative active site [active] 426355007607 heme pocket [chemical binding]; other site 426355007608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355007609 dimer interface [polypeptide binding]; other site 426355007610 phosphorylation site [posttranslational modification] 426355007611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355007612 ATP binding site [chemical binding]; other site 426355007613 Mg2+ binding site [ion binding]; other site 426355007614 G-X-G motif; other site 426355007615 formyl-coenzyme A transferase; Provisional; Region: PRK05398 426355007616 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426355007617 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 426355007618 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 426355007619 active site 426355007620 substrate binding site [chemical binding]; other site 426355007621 cosubstrate binding site; other site 426355007622 catalytic site [active] 426355007623 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 426355007624 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 426355007625 intersubunit interface [polypeptide binding]; other site 426355007626 active site 426355007627 Zn2+ binding site [ion binding]; other site 426355007628 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 426355007629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355007630 putative substrate translocation pore; other site 426355007631 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426355007632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355007633 DNA-binding site [nucleotide binding]; DNA binding site 426355007634 FCD domain; Region: FCD; pfam07729 426355007635 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426355007636 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 426355007637 Zn2+ binding site [ion binding]; other site 426355007638 Mg2+ binding site [ion binding]; other site 426355007639 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 426355007640 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 426355007641 DHH family; Region: DHH; pfam01368 426355007642 DHHA1 domain; Region: DHHA1; pfam02272 426355007643 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 426355007644 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 426355007645 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 426355007646 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 426355007647 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 426355007648 ligand binding site [chemical binding]; other site 426355007649 homodimer interface [polypeptide binding]; other site 426355007650 NAD(P) binding site [chemical binding]; other site 426355007651 trimer interface B [polypeptide binding]; other site 426355007652 trimer interface A [polypeptide binding]; other site 426355007653 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 426355007654 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 426355007655 ABC1 family; Region: ABC1; cl17513 426355007656 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 426355007657 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 426355007658 active site 426355007659 Zn binding site [ion binding]; other site 426355007660 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 426355007661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355007662 active site 426355007663 phosphorylation site [posttranslational modification] 426355007664 intermolecular recognition site; other site 426355007665 dimerization interface [polypeptide binding]; other site 426355007666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355007667 Walker A motif; other site 426355007668 ATP binding site [chemical binding]; other site 426355007669 Walker B motif; other site 426355007670 arginine finger; other site 426355007671 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 426355007672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 426355007673 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426355007674 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426355007675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 426355007676 Peptidase M15; Region: Peptidase_M15_3; cl01194 426355007677 pyruvate phosphate dikinase; Provisional; Region: PRK09279 426355007678 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 426355007679 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 426355007680 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 426355007681 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cd09224 426355007682 subunit interface [polypeptide binding]; other site 426355007683 Heme binding sites [chemical binding]; other site 426355007684 Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291 426355007685 subunit H interface; other site 426355007686 subunit L interface; other site 426355007687 bacteriopheophytin binding site; other site 426355007688 carotenoid binding site; other site 426355007689 bacteriochlorophyll binding site; other site 426355007690 cytochrome C interface; other site 426355007691 quinone binding site; other site 426355007692 Fe binding site [ion binding]; other site 426355007693 Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290 426355007694 subunit M interface; other site 426355007695 subunit H interface; other site 426355007696 quinone binding site; other site 426355007697 bacteriopheophytin binding site; other site 426355007698 bacteriochlorophyll binding site; other site 426355007699 cytochrome C subunit interface; other site 426355007700 Fe binding site [ion binding]; other site 426355007701 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 426355007702 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 426355007703 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 426355007704 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 426355007705 Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY). Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980 426355007706 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426355007707 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 426355007708 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 426355007709 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 426355007710 putative NAD(P) binding site [chemical binding]; other site 426355007711 O-methyltransferase; Region: Methyltransf_2; pfam00891 426355007712 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 426355007713 substrate binding pocket [chemical binding]; other site 426355007714 chain length determination region; other site 426355007715 substrate-Mg2+ binding site; other site 426355007716 catalytic residues [active] 426355007717 aspartate-rich region 1; other site 426355007718 active site lid residues [active] 426355007719 aspartate-rich region 2; other site 426355007720 phytoene desaturase; Region: crtI_fam; TIGR02734 426355007721 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 426355007722 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 426355007723 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 426355007724 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 426355007725 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 426355007726 putative ADP-binding pocket [chemical binding]; other site 426355007727 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355007728 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 426355007729 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 426355007730 NodB motif; other site 426355007731 putative active site [active] 426355007732 putative catalytic site [active] 426355007733 putative Zn binding site [ion binding]; other site 426355007734 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 426355007735 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355007736 Walker A/P-loop; other site 426355007737 ATP binding site [chemical binding]; other site 426355007738 Q-loop/lid; other site 426355007739 ABC transporter signature motif; other site 426355007740 Walker B; other site 426355007741 D-loop; other site 426355007742 H-loop/switch region; other site 426355007743 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426355007744 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355007745 Walker A/P-loop; other site 426355007746 ATP binding site [chemical binding]; other site 426355007747 Q-loop/lid; other site 426355007748 ABC transporter signature motif; other site 426355007749 Walker B; other site 426355007750 D-loop; other site 426355007751 H-loop/switch region; other site 426355007752 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426355007753 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 426355007754 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426355007755 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426355007756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355007757 dimer interface [polypeptide binding]; other site 426355007758 conserved gate region; other site 426355007759 ABC-ATPase subunit interface; other site 426355007760 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 426355007761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355007762 putative PBP binding loops; other site 426355007763 ABC-ATPase subunit interface; other site 426355007764 PAS domain S-box; Region: sensory_box; TIGR00229 426355007765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355007766 putative active site [active] 426355007767 heme pocket [chemical binding]; other site 426355007768 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355007769 HWE histidine kinase; Region: HWE_HK; pfam07536 426355007770 Rdx family; Region: Rdx; cl01407 426355007771 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 426355007772 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 426355007773 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 426355007774 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 426355007775 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426355007776 putative active site [active] 426355007777 putative metal binding site [ion binding]; other site 426355007778 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 426355007779 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 426355007780 domain interfaces; other site 426355007781 active site 426355007782 hypothetical protein; Provisional; Region: PRK10281 426355007783 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 426355007784 active site lid residues [active] 426355007785 substrate binding pocket [chemical binding]; other site 426355007786 catalytic residues [active] 426355007787 substrate-Mg2+ binding site; other site 426355007788 aspartate-rich region 1; other site 426355007789 aspartate-rich region 2; other site 426355007790 phytoene desaturase; Region: crtI_fam; TIGR02734 426355007791 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426355007792 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 426355007793 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 426355007794 NADP binding site [chemical binding]; other site 426355007795 active site 426355007796 putative substrate binding site [chemical binding]; other site 426355007797 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 426355007798 active site 426355007799 catalytic triad [active] 426355007800 oxyanion hole [active] 426355007801 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 426355007802 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 426355007803 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426355007804 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 426355007805 active site 426355007806 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 426355007807 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 426355007808 Uncharacterized conserved protein [Function unknown]; Region: COG3777 426355007809 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 426355007810 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 426355007811 active site 2 [active] 426355007812 active site 1 [active] 426355007813 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426355007814 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426355007815 active site 426355007816 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 426355007817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355007818 NAD(P) binding site [chemical binding]; other site 426355007819 active site 426355007820 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 426355007821 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426355007822 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 426355007823 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426355007824 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355007825 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355007826 Isochorismatase family; Region: Isochorismatase; pfam00857 426355007827 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 426355007828 catalytic triad [active] 426355007829 conserved cis-peptide bond; other site 426355007830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426355007831 Coenzyme A binding pocket [chemical binding]; other site 426355007832 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355007833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355007834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426355007835 dimerization interface [polypeptide binding]; other site 426355007836 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 426355007837 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 426355007838 alpha-gamma subunit interface [polypeptide binding]; other site 426355007839 beta-gamma subunit interface [polypeptide binding]; other site 426355007840 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 426355007841 alpha-beta subunit interface [polypeptide binding]; other site 426355007842 urease subunit alpha; Reviewed; Region: ureC; PRK13207 426355007843 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 426355007844 subunit interactions [polypeptide binding]; other site 426355007845 active site 426355007846 flap region; other site 426355007847 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 426355007848 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 426355007849 dimer interface [polypeptide binding]; other site 426355007850 catalytic residues [active] 426355007851 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 426355007852 UreF; Region: UreF; pfam01730 426355007853 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426355007854 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 426355007855 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 426355007856 Na binding site [ion binding]; other site 426355007857 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 426355007858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 426355007859 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 426355007860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355007861 dimer interface [polypeptide binding]; other site 426355007862 conserved gate region; other site 426355007863 putative PBP binding loops; other site 426355007864 ABC-ATPase subunit interface; other site 426355007865 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 426355007866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355007867 Walker A/P-loop; other site 426355007868 ATP binding site [chemical binding]; other site 426355007869 Q-loop/lid; other site 426355007870 ABC transporter signature motif; other site 426355007871 Walker B; other site 426355007872 D-loop; other site 426355007873 H-loop/switch region; other site 426355007874 TOBE domain; Region: TOBE_2; pfam08402 426355007875 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355007876 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355007877 ligand binding site [chemical binding]; other site 426355007878 flexible hinge region; other site 426355007879 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 426355007880 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: PRK13187 426355007881 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 426355007882 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 426355007883 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426355007884 Zn2+ binding site [ion binding]; other site 426355007885 Mg2+ binding site [ion binding]; other site 426355007886 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 426355007887 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426355007888 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426355007889 ABC transporter; Region: ABC_tran_2; pfam12848 426355007890 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426355007891 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426355007892 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 426355007893 inhibitor-cofactor binding pocket; inhibition site 426355007894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355007895 catalytic residue [active] 426355007896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355007897 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 426355007898 putative dimerization interface [polypeptide binding]; other site 426355007899 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426355007900 RibD C-terminal domain; Region: RibD_C; cl17279 426355007901 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 426355007902 Domain of unknown function (DUF336); Region: DUF336; cl01249 426355007903 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 426355007904 peptide binding site [polypeptide binding]; other site 426355007905 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 426355007906 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 426355007907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 426355007908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355007909 dimer interface [polypeptide binding]; other site 426355007910 conserved gate region; other site 426355007911 putative PBP binding loops; other site 426355007912 ABC-ATPase subunit interface; other site 426355007913 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 426355007914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355007915 dimer interface [polypeptide binding]; other site 426355007916 conserved gate region; other site 426355007917 ABC-ATPase subunit interface; other site 426355007918 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 426355007919 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 426355007920 dimerization interface [polypeptide binding]; other site 426355007921 NAD binding site [chemical binding]; other site 426355007922 ligand binding site [chemical binding]; other site 426355007923 catalytic site [active] 426355007924 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 426355007925 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 426355007926 DAK2 domain; Region: Dak2; pfam02734 426355007927 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 426355007928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355007929 dimer interface [polypeptide binding]; other site 426355007930 conserved gate region; other site 426355007931 putative PBP binding loops; other site 426355007932 ABC-ATPase subunit interface; other site 426355007933 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 426355007934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355007935 dimer interface [polypeptide binding]; other site 426355007936 conserved gate region; other site 426355007937 putative PBP binding loops; other site 426355007938 ABC-ATPase subunit interface; other site 426355007939 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 426355007940 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 426355007941 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 426355007942 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 426355007943 Walker A/P-loop; other site 426355007944 ATP binding site [chemical binding]; other site 426355007945 Q-loop/lid; other site 426355007946 ABC transporter signature motif; other site 426355007947 Walker B; other site 426355007948 D-loop; other site 426355007949 H-loop/switch region; other site 426355007950 TOBE domain; Region: TOBE_2; pfam08402 426355007951 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 426355007952 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 426355007953 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 426355007954 FAD binding domain; Region: FAD_binding_4; pfam01565 426355007955 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 426355007956 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 426355007957 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 426355007958 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 426355007959 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426355007960 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426355007961 TM-ABC transporter signature motif; other site 426355007962 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426355007963 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426355007964 Walker A/P-loop; other site 426355007965 ATP binding site [chemical binding]; other site 426355007966 Q-loop/lid; other site 426355007967 ABC transporter signature motif; other site 426355007968 Walker B; other site 426355007969 D-loop; other site 426355007970 H-loop/switch region; other site 426355007971 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426355007972 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426355007973 Walker A/P-loop; other site 426355007974 ATP binding site [chemical binding]; other site 426355007975 Q-loop/lid; other site 426355007976 ABC transporter signature motif; other site 426355007977 Walker B; other site 426355007978 D-loop; other site 426355007979 H-loop/switch region; other site 426355007980 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426355007981 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426355007982 TM-ABC transporter signature motif; other site 426355007983 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355007984 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426355007985 putative ligand binding site [chemical binding]; other site 426355007986 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426355007987 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355007988 DNA-binding site [nucleotide binding]; DNA binding site 426355007989 short chain dehydrogenase; Provisional; Region: PRK12829 426355007990 classical (c) SDRs; Region: SDR_c; cd05233 426355007991 NAD(P) binding site [chemical binding]; other site 426355007992 active site 426355007993 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 426355007994 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 426355007995 FAD binding domain; Region: FAD_binding_4; pfam01565 426355007996 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 426355007997 Transcriptional regulators [Transcription]; Region: FadR; COG2186 426355007998 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355007999 DNA-binding site [nucleotide binding]; DNA binding site 426355008000 FCD domain; Region: FCD; pfam07729 426355008001 Methyltransferase domain; Region: Methyltransf_24; pfam13578 426355008002 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426355008003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355008004 DNA-binding site [nucleotide binding]; DNA binding site 426355008005 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 426355008006 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 426355008007 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 426355008008 DctM-like transporters; Region: DctM; pfam06808 426355008009 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 426355008010 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 426355008011 putative deacylase active site [active] 426355008012 enoyl-CoA hydratase; Provisional; Region: PRK06144 426355008013 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426355008014 substrate binding site [chemical binding]; other site 426355008015 oxyanion hole (OAH) forming residues; other site 426355008016 trimer interface [polypeptide binding]; other site 426355008017 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 426355008018 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426355008019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355008020 D-galactonate transporter; Region: 2A0114; TIGR00893 426355008021 putative substrate translocation pore; other site 426355008022 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 426355008023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355008024 putative substrate translocation pore; other site 426355008025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426355008026 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426355008027 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 426355008028 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 426355008029 putative active site [active] 426355008030 homoserine dehydrogenase; Provisional; Region: PRK06349 426355008031 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 426355008032 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 426355008033 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 426355008034 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 426355008035 putative catalytic site [active] 426355008036 putative phosphate binding site [ion binding]; other site 426355008037 active site 426355008038 metal binding site A [ion binding]; metal-binding site 426355008039 DNA binding site [nucleotide binding] 426355008040 putative AP binding site [nucleotide binding]; other site 426355008041 putative metal binding site B [ion binding]; other site 426355008042 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426355008043 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 426355008044 C-terminal domain interface [polypeptide binding]; other site 426355008045 GSH binding site (G-site) [chemical binding]; other site 426355008046 dimer interface [polypeptide binding]; other site 426355008047 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 426355008048 dimer interface [polypeptide binding]; other site 426355008049 N-terminal domain interface [polypeptide binding]; other site 426355008050 substrate binding pocket (H-site) [chemical binding]; other site 426355008051 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 426355008052 Sel1-like repeats; Region: SEL1; smart00671 426355008053 Sel1-like repeats; Region: SEL1; smart00671 426355008054 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 426355008055 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 426355008056 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 426355008057 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 426355008058 HTH-like domain; Region: HTH_21; pfam13276 426355008059 Integrase core domain; Region: rve; pfam00665 426355008060 Integrase core domain; Region: rve_3; pfam13683 426355008061 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 426355008062 DNA-binding interface [nucleotide binding]; DNA binding site 426355008063 Winged helix-turn helix; Region: HTH_29; pfam13551 426355008064 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 426355008065 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 426355008066 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 426355008067 4Fe-4S binding domain; Region: Fer4; pfam00037 426355008068 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 426355008069 Cysteine-rich domain; Region: CCG; pfam02754 426355008070 Cysteine-rich domain; Region: CCG; pfam02754 426355008071 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 426355008072 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 426355008073 active site 426355008074 Zn binding site [ion binding]; other site 426355008075 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 426355008076 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426355008077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426355008078 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426355008079 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355008080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355008081 active site 426355008082 phosphorylation site [posttranslational modification] 426355008083 intermolecular recognition site; other site 426355008084 dimerization interface [polypeptide binding]; other site 426355008085 hypothetical protein; Provisional; Region: PRK14679 426355008086 Predicted methyltransferases [General function prediction only]; Region: COG0313 426355008087 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 426355008088 putative SAM binding site [chemical binding]; other site 426355008089 putative homodimer interface [polypeptide binding]; other site 426355008090 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355008091 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 426355008092 putative ligand binding site [chemical binding]; other site 426355008093 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 426355008094 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355008095 FeS/SAM binding site; other site 426355008096 HemN C-terminal domain; Region: HemN_C; pfam06969 426355008097 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 426355008098 active site 426355008099 dimerization interface [polypeptide binding]; other site 426355008100 ribonuclease PH; Reviewed; Region: rph; PRK00173 426355008101 Ribonuclease PH; Region: RNase_PH_bact; cd11362 426355008102 hexamer interface [polypeptide binding]; other site 426355008103 active site 426355008104 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 426355008105 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 426355008106 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 426355008107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355008108 putative substrate translocation pore; other site 426355008109 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-2; cd12809 426355008110 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426355008111 catalytic site [active] 426355008112 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 426355008113 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 426355008114 ATP binding site [chemical binding]; other site 426355008115 active site 426355008116 substrate binding site [chemical binding]; other site 426355008117 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355008118 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355008119 ligand binding site [chemical binding]; other site 426355008120 flexible hinge region; other site 426355008121 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 426355008122 Domain of unknown function (DUF329); Region: DUF329; pfam03884 426355008123 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 426355008124 active site 426355008125 dimer interface [polypeptide binding]; other site 426355008126 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 426355008127 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 426355008128 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 426355008129 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 426355008130 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 426355008131 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 426355008132 Ligand binding site [chemical binding]; other site 426355008133 Electron transfer flavoprotein domain; Region: ETF; pfam01012 426355008134 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 426355008135 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 426355008136 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 426355008137 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 426355008138 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 426355008139 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 426355008140 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 426355008141 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 426355008142 NAD(P) binding site [chemical binding]; other site 426355008143 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355008144 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_10; cd06345 426355008145 putative ligand binding site [chemical binding]; other site 426355008146 Protein of unknown function (DUF938); Region: DUF938; pfam06080 426355008147 circadian clock protein KaiC; Reviewed; Region: PRK09302 426355008148 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426355008149 Walker A motif; other site 426355008150 ATP binding site [chemical binding]; other site 426355008151 Walker B motif; other site 426355008152 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426355008153 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426355008154 Walker A motif; other site 426355008155 Walker A motif; other site 426355008156 ATP binding site [chemical binding]; other site 426355008157 Walker B motif; other site 426355008158 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 426355008159 tetramer interface [polypeptide binding]; other site 426355008160 dimer interface [polypeptide binding]; other site 426355008161 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 426355008162 tetramer interface [polypeptide binding]; other site 426355008163 dimer interface [polypeptide binding]; other site 426355008164 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 426355008165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355008166 putative active site [active] 426355008167 heme pocket [chemical binding]; other site 426355008168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355008169 dimer interface [polypeptide binding]; other site 426355008170 phosphorylation site [posttranslational modification] 426355008171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355008172 ATP binding site [chemical binding]; other site 426355008173 Mg2+ binding site [ion binding]; other site 426355008174 G-X-G motif; other site 426355008175 Response regulator receiver domain; Region: Response_reg; pfam00072 426355008176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355008177 active site 426355008178 phosphorylation site [posttranslational modification] 426355008179 intermolecular recognition site; other site 426355008180 dimerization interface [polypeptide binding]; other site 426355008181 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426355008182 active site 426355008183 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426355008184 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 426355008185 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355008186 dimerization interface [polypeptide binding]; other site 426355008187 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355008188 dimer interface [polypeptide binding]; other site 426355008189 putative CheW interface [polypeptide binding]; other site 426355008190 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 426355008191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426355008192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355008193 WHG domain; Region: WHG; pfam13305 426355008194 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 426355008195 catalytic residues [active] 426355008196 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 426355008197 active site 426355008198 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355008199 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 426355008200 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 426355008201 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 426355008202 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 426355008203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355008204 Walker A/P-loop; other site 426355008205 ATP binding site [chemical binding]; other site 426355008206 Q-loop/lid; other site 426355008207 ABC transporter signature motif; other site 426355008208 Walker B; other site 426355008209 D-loop; other site 426355008210 H-loop/switch region; other site 426355008211 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 426355008212 Uncharacterized conserved protein [Function unknown]; Region: COG1434 426355008213 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 426355008214 putative active site [active] 426355008215 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 426355008216 active site 426355008217 phosphorylation site [posttranslational modification] 426355008218 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 426355008219 30S subunit binding site; other site 426355008220 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 426355008221 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 426355008222 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 426355008223 Ligand binding site; other site 426355008224 DXD motif; other site 426355008225 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 426355008226 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 426355008227 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 426355008228 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 426355008229 RNA binding site [nucleotide binding]; other site 426355008230 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355008231 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355008232 flagellin; Reviewed; Region: PRK12688 426355008233 flagellin; Reviewed; Region: PRK12688 426355008234 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 426355008235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355008236 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 426355008237 dimerization interface [polypeptide binding]; other site 426355008238 substrate binding pocket [chemical binding]; other site 426355008239 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426355008240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355008241 NAD(P) binding site [chemical binding]; other site 426355008242 active site 426355008243 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 426355008244 TPP-binding site [chemical binding]; other site 426355008245 dimer interface [polypeptide binding]; other site 426355008246 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 426355008247 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 426355008248 PYR/PP interface [polypeptide binding]; other site 426355008249 dimer interface [polypeptide binding]; other site 426355008250 TPP binding site [chemical binding]; other site 426355008251 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 426355008252 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 426355008253 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426355008254 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 426355008255 DctM-like transporters; Region: DctM; pfam06808 426355008256 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 426355008257 acyl-CoA synthetase; Validated; Region: PRK07470 426355008258 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426355008259 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 426355008260 acyl-activating enzyme (AAE) consensus motif; other site 426355008261 acyl-activating enzyme (AAE) consensus motif; other site 426355008262 putative AMP binding site [chemical binding]; other site 426355008263 putative active site [active] 426355008264 CoA binding site [chemical binding]; other site 426355008265 putative CoA binding site [chemical binding]; other site 426355008266 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 426355008267 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 426355008268 ureidoglycolate hydrolase; Provisional; Region: PRK03606 426355008269 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 426355008270 hypothetical protein; Provisional; Region: PRK11171 426355008271 Cupin domain; Region: Cupin_2; pfam07883 426355008272 Cupin domain; Region: Cupin_2; pfam07883 426355008273 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 426355008274 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 426355008275 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 426355008276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355008277 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426355008278 dimerization interface [polypeptide binding]; other site 426355008279 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 426355008280 active site 426355008281 PAS fold; Region: PAS_4; pfam08448 426355008282 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355008283 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355008284 metal binding site [ion binding]; metal-binding site 426355008285 active site 426355008286 I-site; other site 426355008287 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355008288 CHASE3 domain; Region: CHASE3; pfam05227 426355008289 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 426355008290 dimerization interface [polypeptide binding]; other site 426355008291 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426355008292 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355008293 dimer interface [polypeptide binding]; other site 426355008294 putative CheW interface [polypeptide binding]; other site 426355008295 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 426355008296 active site 426355008297 catalytic triad [active] 426355008298 oxyanion hole [active] 426355008299 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 426355008300 nucleophilic elbow; other site 426355008301 catalytic triad; other site 426355008302 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 426355008303 flagellin; Reviewed; Region: PRK12688 426355008304 flagellin; Reviewed; Region: PRK12688 426355008305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355008306 PAS domain; Region: PAS_9; pfam13426 426355008307 putative active site [active] 426355008308 heme pocket [chemical binding]; other site 426355008309 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 426355008310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355008311 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 426355008312 putative active site [active] 426355008313 heme pocket [chemical binding]; other site 426355008314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355008315 dimer interface [polypeptide binding]; other site 426355008316 phosphorylation site [posttranslational modification] 426355008317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355008318 ATP binding site [chemical binding]; other site 426355008319 Mg2+ binding site [ion binding]; other site 426355008320 G-X-G motif; other site 426355008321 Response regulator receiver domain; Region: Response_reg; pfam00072 426355008322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355008323 active site 426355008324 phosphorylation site [posttranslational modification] 426355008325 intermolecular recognition site; other site 426355008326 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 426355008327 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 426355008328 Caspase domain; Region: Peptidase_C14; pfam00656 426355008329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426355008330 binding surface 426355008331 TPR motif; other site 426355008332 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 426355008333 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426355008334 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 426355008335 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 426355008336 ligand binding site [chemical binding]; other site 426355008337 PAS fold; Region: PAS_3; pfam08447 426355008338 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355008339 putative active site [active] 426355008340 heme pocket [chemical binding]; other site 426355008341 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 426355008342 Histidine kinase; Region: HisKA_3; pfam07730 426355008343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355008344 ATP binding site [chemical binding]; other site 426355008345 Mg2+ binding site [ion binding]; other site 426355008346 G-X-G motif; other site 426355008347 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426355008348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355008349 active site 426355008350 phosphorylation site [posttranslational modification] 426355008351 intermolecular recognition site; other site 426355008352 dimerization interface [polypeptide binding]; other site 426355008353 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355008354 DNA binding residues [nucleotide binding] 426355008355 dimerization interface [polypeptide binding]; other site 426355008356 Protein of unknown function (DUF808); Region: DUF808; cl01002 426355008357 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 426355008358 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426355008359 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355008360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426355008361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355008362 PAS fold; Region: PAS_4; pfam08448 426355008363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 426355008364 putative active site [active] 426355008365 heme pocket [chemical binding]; other site 426355008366 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355008367 PAS fold; Region: PAS_3; pfam08447 426355008368 putative active site [active] 426355008369 heme pocket [chemical binding]; other site 426355008370 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355008371 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355008372 dimer interface [polypeptide binding]; other site 426355008373 phosphorylation site [posttranslational modification] 426355008374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355008375 ATP binding site [chemical binding]; other site 426355008376 Mg2+ binding site [ion binding]; other site 426355008377 G-X-G motif; other site 426355008378 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355008379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355008380 active site 426355008381 phosphorylation site [posttranslational modification] 426355008382 intermolecular recognition site; other site 426355008383 dimerization interface [polypeptide binding]; other site 426355008384 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426355008385 GAF domain; Region: GAF; pfam01590 426355008386 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355008387 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 426355008388 putative active site [active] 426355008389 heme pocket [chemical binding]; other site 426355008390 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355008391 putative active site [active] 426355008392 heme pocket [chemical binding]; other site 426355008393 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355008394 PAS fold; Region: PAS_3; pfam08447 426355008395 putative active site [active] 426355008396 heme pocket [chemical binding]; other site 426355008397 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355008398 PAS fold; Region: PAS_3; pfam08447 426355008399 putative active site [active] 426355008400 heme pocket [chemical binding]; other site 426355008401 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355008402 PAS fold; Region: PAS_3; pfam08447 426355008403 putative active site [active] 426355008404 heme pocket [chemical binding]; other site 426355008405 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355008406 HWE histidine kinase; Region: HWE_HK; pfam07536 426355008407 Predicted membrane protein [Function unknown]; Region: COG3918 426355008408 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 426355008409 putative ATP binding site [chemical binding]; other site 426355008410 putative substrate binding site [chemical binding]; other site 426355008411 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 426355008412 nudix motif; other site 426355008413 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 426355008414 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 426355008415 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 426355008416 FAD binding domain; Region: FAD_binding_4; pfam01565 426355008417 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 426355008418 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426355008419 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 426355008420 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 426355008421 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 426355008422 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 426355008423 NAD(P) binding site [chemical binding]; other site 426355008424 catalytic residues [active] 426355008425 Uncharacterized conserved protein [Function unknown]; Region: COG3268 426355008426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355008427 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 426355008428 galactarate dehydratase; Region: galactar-dH20; TIGR03248 426355008429 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 426355008430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355008431 D-galactonate transporter; Region: 2A0114; TIGR00893 426355008432 putative substrate translocation pore; other site 426355008433 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 426355008434 Uncharacterized conserved protein [Function unknown]; Region: COG5476 426355008435 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 426355008436 MlrC C-terminus; Region: MlrC_C; pfam07171 426355008437 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 426355008438 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 426355008439 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 426355008440 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 426355008441 putative acyl-acceptor binding pocket; other site 426355008442 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 426355008443 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 426355008444 putative NAD(P) binding site [chemical binding]; other site 426355008445 structural Zn binding site [ion binding]; other site 426355008446 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 426355008447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355008448 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426355008449 NAD(P) binding site [chemical binding]; other site 426355008450 active site 426355008451 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 426355008452 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 426355008453 dimer interface [polypeptide binding]; other site 426355008454 active site 426355008455 allantoate amidohydrolase; Reviewed; Region: PRK09290 426355008456 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 426355008457 active site 426355008458 metal binding site [ion binding]; metal-binding site 426355008459 dimer interface [polypeptide binding]; other site 426355008460 tellurite resistance protein terB; Region: terB; cd07176 426355008461 putative metal binding site [ion binding]; other site 426355008462 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 426355008463 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 426355008464 Uncharacterized conserved protein [Function unknown]; Region: COG3025 426355008465 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 426355008466 putative active site [active] 426355008467 putative metal binding residues [ion binding]; other site 426355008468 signature motif; other site 426355008469 putative triphosphate binding site [ion binding]; other site 426355008470 CHAD domain; Region: CHAD; pfam05235 426355008471 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 426355008472 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 426355008473 G1 box; other site 426355008474 GTP/Mg2+ binding site [chemical binding]; other site 426355008475 G2 box; other site 426355008476 Switch I region; other site 426355008477 G3 box; other site 426355008478 Switch II region; other site 426355008479 G4 box; other site 426355008480 G5 box; other site 426355008481 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 426355008482 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 426355008483 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 426355008484 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 426355008485 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 426355008486 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 426355008487 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 426355008488 active site 426355008489 catalytic triad [active] 426355008490 oxyanion hole [active] 426355008491 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 426355008492 active site 426355008493 HslU subunit interaction site [polypeptide binding]; other site 426355008494 CHASE3 domain; Region: CHASE3; pfam05227 426355008495 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355008496 dimer interface [polypeptide binding]; other site 426355008497 putative CheW interface [polypeptide binding]; other site 426355008498 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426355008499 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355008500 dimerization interface [polypeptide binding]; other site 426355008501 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355008502 dimer interface [polypeptide binding]; other site 426355008503 putative CheW interface [polypeptide binding]; other site 426355008504 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 426355008505 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 426355008506 Sulfate transporter family; Region: Sulfate_transp; pfam00916 426355008507 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 426355008508 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 426355008509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355008510 Walker A motif; other site 426355008511 ATP binding site [chemical binding]; other site 426355008512 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 426355008513 Walker B motif; other site 426355008514 arginine finger; other site 426355008515 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 426355008516 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 426355008517 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 426355008518 active pocket/dimerization site; other site 426355008519 active site 426355008520 phosphorylation site [posttranslational modification] 426355008521 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 426355008522 Hpr binding site; other site 426355008523 active site 426355008524 homohexamer subunit interaction site [polypeptide binding]; other site 426355008525 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 426355008526 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 426355008527 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355008528 HAMP domain; Region: HAMP; pfam00672 426355008529 dimerization interface [polypeptide binding]; other site 426355008530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355008531 dimer interface [polypeptide binding]; other site 426355008532 phosphorylation site [posttranslational modification] 426355008533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355008534 ATP binding site [chemical binding]; other site 426355008535 Mg2+ binding site [ion binding]; other site 426355008536 G-X-G motif; other site 426355008537 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355008538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355008539 active site 426355008540 phosphorylation site [posttranslational modification] 426355008541 intermolecular recognition site; other site 426355008542 dimerization interface [polypeptide binding]; other site 426355008543 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355008544 DNA binding site [nucleotide binding] 426355008545 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 426355008546 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 426355008547 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 426355008548 GTP-binding protein LepA; Provisional; Region: PRK05433 426355008549 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 426355008550 G1 box; other site 426355008551 putative GEF interaction site [polypeptide binding]; other site 426355008552 GTP/Mg2+ binding site [chemical binding]; other site 426355008553 Switch I region; other site 426355008554 G2 box; other site 426355008555 G3 box; other site 426355008556 Switch II region; other site 426355008557 G4 box; other site 426355008558 G5 box; other site 426355008559 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 426355008560 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 426355008561 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 426355008562 Cytochrome c553 [Energy production and conversion]; Region: COG2863 426355008563 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 426355008564 hypothetical protein; Provisional; Region: PRK07208 426355008565 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426355008566 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 426355008567 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 426355008568 dimer interface [polypeptide binding]; other site 426355008569 putative functional site; other site 426355008570 putative MPT binding site; other site 426355008571 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 426355008572 trimer interface [polypeptide binding]; other site 426355008573 dimer interface [polypeptide binding]; other site 426355008574 putative active site [active] 426355008575 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 426355008576 active site 426355008577 ribulose/triose binding site [chemical binding]; other site 426355008578 phosphate binding site [ion binding]; other site 426355008579 substrate (anthranilate) binding pocket [chemical binding]; other site 426355008580 product (indole) binding pocket [chemical binding]; other site 426355008581 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 426355008582 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 426355008583 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 426355008584 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 426355008585 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 426355008586 glutamine binding [chemical binding]; other site 426355008587 catalytic triad [active] 426355008588 anthranilate synthase component I; Provisional; Region: PRK13573 426355008589 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 426355008590 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 426355008591 SurA N-terminal domain; Region: SurA_N_3; cl07813 426355008592 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 426355008593 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 426355008594 triosephosphate isomerase; Provisional; Region: PRK14565 426355008595 substrate binding site [chemical binding]; other site 426355008596 dimer interface [polypeptide binding]; other site 426355008597 catalytic triad [active] 426355008598 SnoaL-like domain; Region: SnoaL_2; pfam12680 426355008599 CTP synthetase; Validated; Region: pyrG; PRK05380 426355008600 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 426355008601 Catalytic site [active] 426355008602 active site 426355008603 UTP binding site [chemical binding]; other site 426355008604 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 426355008605 active site 426355008606 putative oxyanion hole; other site 426355008607 catalytic triad [active] 426355008608 DNA polymerase III subunit chi; Validated; Region: PRK05728 426355008609 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 426355008610 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 426355008611 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 426355008612 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 426355008613 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 426355008614 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 426355008615 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 426355008616 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321 426355008617 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 426355008618 precorrin-3B synthase; Region: CobG; TIGR02435 426355008619 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 426355008620 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 426355008621 Precorrin-8X methylmutase; Region: CbiC; pfam02570 426355008622 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 426355008623 active site 426355008624 SAM binding site [chemical binding]; other site 426355008625 homodimer interface [polypeptide binding]; other site 426355008626 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 426355008627 active site 426355008628 SAM binding site [chemical binding]; other site 426355008629 homodimer interface [polypeptide binding]; other site 426355008630 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 426355008631 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 426355008632 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 426355008633 active site 426355008634 putative homodimer interface [polypeptide binding]; other site 426355008635 SAM binding site [chemical binding]; other site 426355008636 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 426355008637 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 426355008638 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 426355008639 active site 426355008640 SAM binding site [chemical binding]; other site 426355008641 homodimer interface [polypeptide binding]; other site 426355008642 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 426355008643 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 426355008644 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426355008645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355008646 non-specific DNA binding site [nucleotide binding]; other site 426355008647 salt bridge; other site 426355008648 sequence-specific DNA binding site [nucleotide binding]; other site 426355008649 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 426355008650 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 426355008651 Bacterial sugar transferase; Region: Bac_transf; pfam02397 426355008652 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 426355008653 metal binding site 2 [ion binding]; metal-binding site 426355008654 putative DNA binding helix; other site 426355008655 metal binding site 1 [ion binding]; metal-binding site 426355008656 dimer interface [polypeptide binding]; other site 426355008657 structural Zn2+ binding site [ion binding]; other site 426355008658 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 426355008659 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 426355008660 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 426355008661 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 426355008662 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 426355008663 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355008664 putative NAD(P) binding site [chemical binding]; other site 426355008665 epoxyqueuosine reductase; Region: TIGR00276 426355008666 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 426355008667 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426355008668 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 426355008669 C-terminal domain interface [polypeptide binding]; other site 426355008670 GSH binding site (G-site) [chemical binding]; other site 426355008671 dimer interface [polypeptide binding]; other site 426355008672 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 426355008673 N-terminal domain interface [polypeptide binding]; other site 426355008674 dimer interface [polypeptide binding]; other site 426355008675 substrate binding pocket (H-site) [chemical binding]; other site 426355008676 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 426355008677 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 426355008678 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 426355008679 heterodimer interface [polypeptide binding]; other site 426355008680 substrate interaction site [chemical binding]; other site 426355008681 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 426355008682 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 426355008683 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 426355008684 dimer interface [polypeptide binding]; other site 426355008685 N-terminal domain interface [polypeptide binding]; other site 426355008686 substrate binding pocket (H-site) [chemical binding]; other site 426355008687 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 426355008688 N-terminal domain interface [polypeptide binding]; other site 426355008689 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 426355008690 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 426355008691 Catalytic domain of Protein Kinases; Region: PKc; cd00180 426355008692 active site 426355008693 ATP binding site [chemical binding]; other site 426355008694 substrate binding site [chemical binding]; other site 426355008695 activation loop (A-loop); other site 426355008696 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 426355008697 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 426355008698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355008699 Walker A motif; other site 426355008700 ATP binding site [chemical binding]; other site 426355008701 Walker B motif; other site 426355008702 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 426355008703 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 426355008704 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 426355008705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355008706 Walker A motif; other site 426355008707 ATP binding site [chemical binding]; other site 426355008708 Walker B motif; other site 426355008709 arginine finger; other site 426355008710 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 426355008711 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 426355008712 hypothetical protein; Validated; Region: PRK00153 426355008713 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 426355008714 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 426355008715 active site 426355008716 substrate-binding site [chemical binding]; other site 426355008717 metal-binding site [ion binding] 426355008718 ATP binding site [chemical binding]; other site 426355008719 recombination protein RecR; Reviewed; Region: recR; PRK00076 426355008720 RecR protein; Region: RecR; pfam02132 426355008721 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 426355008722 putative active site [active] 426355008723 putative metal-binding site [ion binding]; other site 426355008724 tetramer interface [polypeptide binding]; other site 426355008725 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 426355008726 active site 426355008727 catalytic residues [active] 426355008728 metal binding site [ion binding]; metal-binding site 426355008729 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 426355008730 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 426355008731 putative active site [active] 426355008732 substrate binding site [chemical binding]; other site 426355008733 putative cosubstrate binding site; other site 426355008734 catalytic site [active] 426355008735 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 426355008736 substrate binding site [chemical binding]; other site 426355008737 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 426355008738 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 426355008739 dimerization interface 3.5A [polypeptide binding]; other site 426355008740 active site 426355008741 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 426355008742 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 426355008743 metal binding site [ion binding]; metal-binding site 426355008744 dimer interface [polypeptide binding]; other site 426355008745 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 426355008746 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 426355008747 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355008748 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 426355008749 putative ADP-binding pocket [chemical binding]; other site 426355008750 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 426355008751 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 426355008752 23S rRNA binding site [nucleotide binding]; other site 426355008753 L21 binding site [polypeptide binding]; other site 426355008754 L13 binding site [polypeptide binding]; other site 426355008755 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 426355008756 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 426355008757 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 426355008758 dimer interface [polypeptide binding]; other site 426355008759 motif 1; other site 426355008760 active site 426355008761 motif 2; other site 426355008762 motif 3; other site 426355008763 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 426355008764 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 426355008765 putative tRNA-binding site [nucleotide binding]; other site 426355008766 B3/4 domain; Region: B3_4; pfam03483 426355008767 tRNA synthetase B5 domain; Region: B5; smart00874 426355008768 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 426355008769 dimer interface [polypeptide binding]; other site 426355008770 motif 1; other site 426355008771 motif 3; other site 426355008772 motif 2; other site 426355008773 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 426355008774 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 426355008775 SEC-C motif; Region: SEC-C; pfam02810 426355008776 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 426355008777 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 426355008778 ATP binding site [chemical binding]; other site 426355008779 substrate interface [chemical binding]; other site 426355008780 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 426355008781 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 426355008782 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 426355008783 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 426355008784 putative ADP-binding pocket [chemical binding]; other site 426355008785 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355008786 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426355008787 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426355008788 Uncharacterized small protein [Function unknown]; Region: COG5568 426355008789 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 426355008790 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 426355008791 putative dimer interface [polypeptide binding]; other site 426355008792 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 426355008793 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 426355008794 TolR protein; Region: tolR; TIGR02801 426355008795 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 426355008796 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 426355008797 hypothetical protein; Validated; Region: PRK00124 426355008798 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426355008799 cyclase homology domain; Region: CHD; cd07302 426355008800 nucleotidyl binding site; other site 426355008801 metal binding site [ion binding]; metal-binding site 426355008802 dimer interface [polypeptide binding]; other site 426355008803 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426355008804 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426355008805 active site 426355008806 catalytic tetrad [active] 426355008807 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355008808 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355008809 metal binding site [ion binding]; metal-binding site 426355008810 active site 426355008811 I-site; other site 426355008812 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 426355008813 Transglycosylase; Region: Transgly; pfam00912 426355008814 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 426355008815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355008816 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426355008817 dimerization interface [polypeptide binding]; other site 426355008818 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 426355008819 Predicted membrane protein [Function unknown]; Region: COG4763 426355008820 Acyltransferase family; Region: Acyl_transf_3; pfam01757 426355008821 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 426355008822 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 426355008823 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 426355008824 ThiC-associated domain; Region: ThiC-associated; pfam13667 426355008825 ThiC family; Region: ThiC; pfam01964 426355008826 FlaG protein; Region: FlaG; cl00591 426355008827 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 426355008828 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 426355008829 putative active site [active] 426355008830 putative dimer interface [polypeptide binding]; other site 426355008831 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 426355008832 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 426355008833 active site 426355008834 dimer interface [polypeptide binding]; other site 426355008835 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 426355008836 Ligand Binding Site [chemical binding]; other site 426355008837 Molecular Tunnel; other site 426355008838 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 426355008839 active site 426355008840 PRC-barrel domain; Region: PRC; pfam05239 426355008841 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 426355008842 FOG: WD40 repeat [General function prediction only]; Region: COG2319 426355008843 structural tetrad; other site 426355008844 Cytochrome c; Region: Cytochrom_C; cl11414 426355008845 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 426355008846 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 426355008847 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 426355008848 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 426355008849 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 426355008850 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 426355008851 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 426355008852 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 426355008853 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 426355008854 [4Fe-4S] binding site [ion binding]; other site 426355008855 molybdopterin cofactor binding site; other site 426355008856 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426355008857 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 426355008858 molybdopterin cofactor binding site; other site 426355008859 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 426355008860 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 426355008861 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 426355008862 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 426355008863 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355008864 dimerization interface [polypeptide binding]; other site 426355008865 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355008866 dimerization interface [polypeptide binding]; other site 426355008867 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355008868 dimerization interface [polypeptide binding]; other site 426355008869 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 426355008870 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355008871 dimerization interface [polypeptide binding]; other site 426355008872 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355008873 dimerization interface [polypeptide binding]; other site 426355008874 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355008875 dimerization interface [polypeptide binding]; other site 426355008876 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355008877 dimerization interface [polypeptide binding]; other site 426355008878 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 426355008879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355008880 dimerization interface [polypeptide binding]; other site 426355008881 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355008882 dimerization interface [polypeptide binding]; other site 426355008883 GAF domain; Region: GAF_2; pfam13185 426355008884 GAF domain; Region: GAF_3; pfam13492 426355008885 pinin/SDK/memA/ protein conserved region; Region: Pinin_SDK_memA; pfam04696 426355008886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355008887 dimer interface [polypeptide binding]; other site 426355008888 phosphorylation site [posttranslational modification] 426355008889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355008890 ATP binding site [chemical binding]; other site 426355008891 Mg2+ binding site [ion binding]; other site 426355008892 G-X-G motif; other site 426355008893 Response regulator receiver domain; Region: Response_reg; pfam00072 426355008894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355008895 active site 426355008896 phosphorylation site [posttranslational modification] 426355008897 intermolecular recognition site; other site 426355008898 dimerization interface [polypeptide binding]; other site 426355008899 Response regulator receiver domain; Region: Response_reg; pfam00072 426355008900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355008901 active site 426355008902 phosphorylation site [posttranslational modification] 426355008903 intermolecular recognition site; other site 426355008904 dimerization interface [polypeptide binding]; other site 426355008905 Response regulator receiver domain; Region: Response_reg; pfam00072 426355008906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355008907 active site 426355008908 phosphorylation site [posttranslational modification] 426355008909 intermolecular recognition site; other site 426355008910 dimerization interface [polypeptide binding]; other site 426355008911 Response regulator receiver domain; Region: Response_reg; pfam00072 426355008912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355008913 active site 426355008914 phosphorylation site [posttranslational modification] 426355008915 intermolecular recognition site; other site 426355008916 dimerization interface [polypeptide binding]; other site 426355008917 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 426355008918 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355008919 putative active site [active] 426355008920 heme pocket [chemical binding]; other site 426355008921 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355008922 dimer interface [polypeptide binding]; other site 426355008923 phosphorylation site [posttranslational modification] 426355008924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355008925 ATP binding site [chemical binding]; other site 426355008926 Mg2+ binding site [ion binding]; other site 426355008927 G-X-G motif; other site 426355008928 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355008929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355008930 active site 426355008931 phosphorylation site [posttranslational modification] 426355008932 intermolecular recognition site; other site 426355008933 dimerization interface [polypeptide binding]; other site 426355008934 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 426355008935 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 426355008936 putative ligand binding site [chemical binding]; other site 426355008937 NAD binding site [chemical binding]; other site 426355008938 dimerization interface [polypeptide binding]; other site 426355008939 catalytic site [active] 426355008940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355008941 DNA-binding site [nucleotide binding]; DNA binding site 426355008942 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426355008943 FCD domain; Region: FCD; pfam07729 426355008944 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 426355008945 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426355008946 inhibitor-cofactor binding pocket; inhibition site 426355008947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355008948 catalytic residue [active] 426355008949 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 426355008950 active site 426355008951 substrate binding site [chemical binding]; other site 426355008952 ATP binding site [chemical binding]; other site 426355008953 putative amidase; Provisional; Region: PRK06169 426355008954 Amidase; Region: Amidase; pfam01425 426355008955 aminotransferase; Provisional; Region: PRK06105 426355008956 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426355008957 inhibitor-cofactor binding pocket; inhibition site 426355008958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355008959 catalytic residue [active] 426355008960 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 426355008961 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355008962 Walker A/P-loop; other site 426355008963 ATP binding site [chemical binding]; other site 426355008964 Q-loop/lid; other site 426355008965 ABC transporter signature motif; other site 426355008966 Walker B; other site 426355008967 D-loop; other site 426355008968 H-loop/switch region; other site 426355008969 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426355008970 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355008971 Walker A/P-loop; other site 426355008972 ATP binding site [chemical binding]; other site 426355008973 Q-loop/lid; other site 426355008974 ABC transporter signature motif; other site 426355008975 Walker B; other site 426355008976 D-loop; other site 426355008977 H-loop/switch region; other site 426355008978 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426355008979 dipeptide transporter; Provisional; Region: PRK10913 426355008980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355008981 dimer interface [polypeptide binding]; other site 426355008982 conserved gate region; other site 426355008983 putative PBP binding loops; other site 426355008984 ABC-ATPase subunit interface; other site 426355008985 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426355008986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355008987 dimer interface [polypeptide binding]; other site 426355008988 conserved gate region; other site 426355008989 putative PBP binding loops; other site 426355008990 ABC-ATPase subunit interface; other site 426355008991 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426355008992 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 426355008993 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426355008994 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 426355008995 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 426355008996 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 426355008997 putative ligand binding site [chemical binding]; other site 426355008998 NAD binding site [chemical binding]; other site 426355008999 dimerization interface [polypeptide binding]; other site 426355009000 catalytic site [active] 426355009001 Dehydroquinase class II; Region: DHquinase_II; pfam01220 426355009002 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 426355009003 trimer interface [polypeptide binding]; other site 426355009004 active site 426355009005 dimer interface [polypeptide binding]; other site 426355009006 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355009007 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355009008 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 426355009009 putative substrate binding pocket [chemical binding]; other site 426355009010 dimerization interface [polypeptide binding]; other site 426355009011 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 426355009012 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 426355009013 homotrimer interaction site [polypeptide binding]; other site 426355009014 putative active site [active] 426355009015 putative glutathione S-transferase; Provisional; Region: PRK10357 426355009016 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 426355009017 putative C-terminal domain interface [polypeptide binding]; other site 426355009018 putative GSH binding site (G-site) [chemical binding]; other site 426355009019 putative dimer interface [polypeptide binding]; other site 426355009020 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 426355009021 N-terminal domain interface [polypeptide binding]; other site 426355009022 dimer interface [polypeptide binding]; other site 426355009023 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 426355009024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355009025 Walker A/P-loop; other site 426355009026 ATP binding site [chemical binding]; other site 426355009027 Q-loop/lid; other site 426355009028 ABC transporter signature motif; other site 426355009029 Walker B; other site 426355009030 D-loop; other site 426355009031 H-loop/switch region; other site 426355009032 TOBE domain; Region: TOBE_2; pfam08402 426355009033 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 426355009034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355009035 dimer interface [polypeptide binding]; other site 426355009036 conserved gate region; other site 426355009037 putative PBP binding loops; other site 426355009038 ABC-ATPase subunit interface; other site 426355009039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355009040 dimer interface [polypeptide binding]; other site 426355009041 conserved gate region; other site 426355009042 putative PBP binding loops; other site 426355009043 ABC-ATPase subunit interface; other site 426355009044 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 426355009045 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 426355009046 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 426355009047 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426355009048 N-terminal plug; other site 426355009049 ligand-binding site [chemical binding]; other site 426355009050 response regulator; Provisional; Region: PRK13435 426355009051 methionine gamma-lyase; Validated; Region: PRK07049 426355009052 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426355009053 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426355009054 catalytic residue [active] 426355009055 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 426355009056 Peptidase family M48; Region: Peptidase_M48; cl12018 426355009057 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 426355009058 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 426355009059 putative [4Fe-4S] binding site [ion binding]; other site 426355009060 putative molybdopterin cofactor binding site [chemical binding]; other site 426355009061 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 426355009062 putative molybdopterin cofactor binding site; other site 426355009063 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 426355009064 SxDxEG motif; other site 426355009065 active site 426355009066 metal binding site [ion binding]; metal-binding site 426355009067 homopentamer interface [polypeptide binding]; other site 426355009068 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 426355009069 homodimer interface [polypeptide binding]; other site 426355009070 homotetramer interface [polypeptide binding]; other site 426355009071 active site pocket [active] 426355009072 cleavage site 426355009073 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 426355009074 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 426355009075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355009076 dimer interface [polypeptide binding]; other site 426355009077 conserved gate region; other site 426355009078 putative PBP binding loops; other site 426355009079 ABC-ATPase subunit interface; other site 426355009080 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 426355009081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355009082 dimer interface [polypeptide binding]; other site 426355009083 conserved gate region; other site 426355009084 putative PBP binding loops; other site 426355009085 ABC-ATPase subunit interface; other site 426355009086 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 426355009087 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 426355009088 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 426355009089 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355009090 Walker A/P-loop; other site 426355009091 ATP binding site [chemical binding]; other site 426355009092 Q-loop/lid; other site 426355009093 ABC transporter signature motif; other site 426355009094 Walker B; other site 426355009095 D-loop; other site 426355009096 H-loop/switch region; other site 426355009097 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355009098 Walker A/P-loop; other site 426355009099 ATP binding site [chemical binding]; other site 426355009100 Q-loop/lid; other site 426355009101 ABC transporter signature motif; other site 426355009102 Walker B; other site 426355009103 D-loop; other site 426355009104 H-loop/switch region; other site 426355009105 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 426355009106 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 426355009107 catalytic nucleophile [active] 426355009108 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 426355009109 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 426355009110 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 426355009111 putative active site [active] 426355009112 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426355009113 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355009114 DNA-binding site [nucleotide binding]; DNA binding site 426355009115 FCD domain; Region: FCD; pfam07729 426355009116 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 426355009117 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 426355009118 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 426355009119 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 426355009120 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426355009121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355009122 metabolite-proton symporter; Region: 2A0106; TIGR00883 426355009123 putative substrate translocation pore; other site 426355009124 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 426355009125 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 426355009126 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426355009127 NAD binding site [chemical binding]; other site 426355009128 catalytic residues [active] 426355009129 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 426355009130 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426355009131 NIPSNAP; Region: NIPSNAP; pfam07978 426355009132 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426355009133 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426355009134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355009135 putative substrate translocation pore; other site 426355009136 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 426355009137 Transcriptional regulator [Transcription]; Region: IclR; COG1414 426355009138 NMT1-like family; Region: NMT1_2; pfam13379 426355009139 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426355009140 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426355009141 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426355009142 active site 426355009143 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426355009144 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426355009145 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 426355009146 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426355009147 enoyl-CoA hydratase; Provisional; Region: PRK09245 426355009148 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426355009149 substrate binding site [chemical binding]; other site 426355009150 oxyanion hole (OAH) forming residues; other site 426355009151 trimer interface [polypeptide binding]; other site 426355009152 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 426355009153 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 426355009154 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 426355009155 DctM-like transporters; Region: DctM; pfam06808 426355009156 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 426355009157 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 426355009158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355009159 putative substrate translocation pore; other site 426355009160 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 426355009161 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426355009162 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 426355009163 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 426355009164 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 426355009165 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426355009166 GAF domain; Region: GAF; pfam01590 426355009167 PAS fold; Region: PAS_3; pfam08447 426355009168 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355009169 heme pocket [chemical binding]; other site 426355009170 putative active site [active] 426355009171 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355009172 PAS fold; Region: PAS_3; pfam08447 426355009173 putative active site [active] 426355009174 heme pocket [chemical binding]; other site 426355009175 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355009176 putative active site [active] 426355009177 heme pocket [chemical binding]; other site 426355009178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355009179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355009180 dimer interface [polypeptide binding]; other site 426355009181 phosphorylation site [posttranslational modification] 426355009182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355009183 ATP binding site [chemical binding]; other site 426355009184 Mg2+ binding site [ion binding]; other site 426355009185 G-X-G motif; other site 426355009186 Response regulator receiver domain; Region: Response_reg; pfam00072 426355009187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355009188 active site 426355009189 phosphorylation site [posttranslational modification] 426355009190 intermolecular recognition site; other site 426355009191 dimerization interface [polypeptide binding]; other site 426355009192 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 426355009193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355009194 FeS/SAM binding site; other site 426355009195 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355009196 putative active site [active] 426355009197 PAS fold; Region: PAS_3; pfam08447 426355009198 heme pocket [chemical binding]; other site 426355009199 PAS domain S-box; Region: sensory_box; TIGR00229 426355009200 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355009201 putative active site [active] 426355009202 heme pocket [chemical binding]; other site 426355009203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355009204 dimer interface [polypeptide binding]; other site 426355009205 phosphorylation site [posttranslational modification] 426355009206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355009207 ATP binding site [chemical binding]; other site 426355009208 Mg2+ binding site [ion binding]; other site 426355009209 G-X-G motif; other site 426355009210 response regulator FixJ; Provisional; Region: fixJ; PRK09390 426355009211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355009212 active site 426355009213 phosphorylation site [posttranslational modification] 426355009214 intermolecular recognition site; other site 426355009215 dimerization interface [polypeptide binding]; other site 426355009216 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355009217 dimerization interface [polypeptide binding]; other site 426355009218 DNA binding residues [nucleotide binding] 426355009219 Response regulator receiver domain; Region: Response_reg; pfam00072 426355009220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355009221 active site 426355009222 phosphorylation site [posttranslational modification] 426355009223 intermolecular recognition site; other site 426355009224 dimerization interface [polypeptide binding]; other site 426355009225 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355009226 ligand binding site [chemical binding]; other site 426355009227 flexible hinge region; other site 426355009228 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426355009229 putative switch regulator; other site 426355009230 non-specific DNA interactions [nucleotide binding]; other site 426355009231 DNA binding site [nucleotide binding] 426355009232 sequence specific DNA binding site [nucleotide binding]; other site 426355009233 putative cAMP binding site [chemical binding]; other site 426355009234 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 426355009235 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 426355009236 Imelysin; Region: Peptidase_M75; pfam09375 426355009237 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355009238 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 426355009239 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 426355009240 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426355009241 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 426355009242 peptide binding site [polypeptide binding]; other site 426355009243 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355009244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355009245 ATP binding site [chemical binding]; other site 426355009246 Mg2+ binding site [ion binding]; other site 426355009247 G-X-G motif; other site 426355009248 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355009249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355009250 active site 426355009251 phosphorylation site [posttranslational modification] 426355009252 intermolecular recognition site; other site 426355009253 dimerization interface [polypeptide binding]; other site 426355009254 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355009255 DNA binding site [nucleotide binding] 426355009256 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 426355009257 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355009258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355009259 dimer interface [polypeptide binding]; other site 426355009260 phosphorylation site [posttranslational modification] 426355009261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355009262 ATP binding site [chemical binding]; other site 426355009263 Mg2+ binding site [ion binding]; other site 426355009264 G-X-G motif; other site 426355009265 Cytochrome c; Region: Cytochrom_C; cl11414 426355009266 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 426355009267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355009268 DNA-binding site [nucleotide binding]; DNA binding site 426355009269 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426355009270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355009271 homodimer interface [polypeptide binding]; other site 426355009272 catalytic residue [active] 426355009273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 426355009274 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355009275 CHASE3 domain; Region: CHASE3; cl05000 426355009276 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 426355009277 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 426355009278 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355009279 dimer interface [polypeptide binding]; other site 426355009280 putative CheW interface [polypeptide binding]; other site 426355009281 PAS fold; Region: PAS_7; pfam12860 426355009282 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355009283 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355009284 metal binding site [ion binding]; metal-binding site 426355009285 active site 426355009286 I-site; other site 426355009287 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355009288 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 426355009289 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 426355009290 Transcriptional regulators [Transcription]; Region: FadR; COG2186 426355009291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355009292 DNA-binding site [nucleotide binding]; DNA binding site 426355009293 FCD domain; Region: FCD; pfam07729 426355009294 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 426355009295 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 426355009296 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 426355009297 putative ligand binding site [chemical binding]; other site 426355009298 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426355009299 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426355009300 TM-ABC transporter signature motif; other site 426355009301 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426355009302 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426355009303 TM-ABC transporter signature motif; other site 426355009304 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 426355009305 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426355009306 Walker A/P-loop; other site 426355009307 ATP binding site [chemical binding]; other site 426355009308 Q-loop/lid; other site 426355009309 ABC transporter signature motif; other site 426355009310 Walker B; other site 426355009311 D-loop; other site 426355009312 H-loop/switch region; other site 426355009313 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426355009314 Walker A/P-loop; other site 426355009315 ATP binding site [chemical binding]; other site 426355009316 Q-loop/lid; other site 426355009317 ABC transporter signature motif; other site 426355009318 Walker B; other site 426355009319 D-loop; other site 426355009320 H-loop/switch region; other site 426355009321 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 426355009322 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 426355009323 putative active site [active] 426355009324 putative catalytic site [active] 426355009325 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 426355009326 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 426355009327 Walker A/P-loop; other site 426355009328 ATP binding site [chemical binding]; other site 426355009329 Q-loop/lid; other site 426355009330 ABC transporter signature motif; other site 426355009331 Walker B; other site 426355009332 D-loop; other site 426355009333 H-loop/switch region; other site 426355009334 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 426355009335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355009336 dimer interface [polypeptide binding]; other site 426355009337 conserved gate region; other site 426355009338 putative PBP binding loops; other site 426355009339 ABC-ATPase subunit interface; other site 426355009340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355009341 dimer interface [polypeptide binding]; other site 426355009342 conserved gate region; other site 426355009343 putative PBP binding loops; other site 426355009344 ABC-ATPase subunit interface; other site 426355009345 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355009346 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426355009347 substrate binding pocket [chemical binding]; other site 426355009348 membrane-bound complex binding site; other site 426355009349 hinge residues; other site 426355009350 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 426355009351 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426355009352 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 426355009353 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 426355009354 conserved cys residue [active] 426355009355 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355009356 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 426355009357 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 426355009358 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 426355009359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426355009360 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426355009361 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426355009362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355009363 NAD(P) binding site [chemical binding]; other site 426355009364 active site 426355009365 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 426355009366 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426355009367 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426355009368 Walker A/P-loop; other site 426355009369 ATP binding site [chemical binding]; other site 426355009370 Q-loop/lid; other site 426355009371 ABC transporter signature motif; other site 426355009372 Walker B; other site 426355009373 D-loop; other site 426355009374 H-loop/switch region; other site 426355009375 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426355009376 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426355009377 Walker A/P-loop; other site 426355009378 ATP binding site [chemical binding]; other site 426355009379 Q-loop/lid; other site 426355009380 ABC transporter signature motif; other site 426355009381 Walker B; other site 426355009382 D-loop; other site 426355009383 H-loop/switch region; other site 426355009384 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426355009385 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426355009386 TM-ABC transporter signature motif; other site 426355009387 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426355009388 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426355009389 TM-ABC transporter signature motif; other site 426355009390 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355009391 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356 426355009392 putative ligand binding site [chemical binding]; other site 426355009393 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 426355009394 ANTAR domain; Region: ANTAR; pfam03861 426355009395 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426355009396 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355009397 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426355009398 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 426355009399 putative C-terminal domain interface [polypeptide binding]; other site 426355009400 putative GSH binding site (G-site) [chemical binding]; other site 426355009401 putative dimer interface [polypeptide binding]; other site 426355009402 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 426355009403 putative N-terminal domain interface [polypeptide binding]; other site 426355009404 putative dimer interface [polypeptide binding]; other site 426355009405 putative substrate binding pocket (H-site) [chemical binding]; other site 426355009406 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 426355009407 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 426355009408 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 426355009409 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 426355009410 FAD binding pocket [chemical binding]; other site 426355009411 FAD binding motif [chemical binding]; other site 426355009412 phosphate binding motif [ion binding]; other site 426355009413 beta-alpha-beta structure motif; other site 426355009414 NAD binding pocket [chemical binding]; other site 426355009415 Heme binding pocket [chemical binding]; other site 426355009416 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355009417 catalytic loop [active] 426355009418 iron binding site [ion binding]; other site 426355009419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 426355009420 SnoaL-like domain; Region: SnoaL_2; pfam12680 426355009421 transcriptional regulator; Provisional; Region: PRK10632 426355009422 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355009423 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 426355009424 putative effector binding pocket; other site 426355009425 putative dimerization interface [polypeptide binding]; other site 426355009426 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426355009427 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 426355009428 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426355009429 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 426355009430 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355009431 PAS domain; Region: PAS_9; pfam13426 426355009432 putative active site [active] 426355009433 heme pocket [chemical binding]; other site 426355009434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355009435 PAS fold; Region: PAS_3; pfam08447 426355009436 putative active site [active] 426355009437 heme pocket [chemical binding]; other site 426355009438 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355009439 HWE histidine kinase; Region: HWE_HK; pfam07536 426355009440 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 426355009441 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 426355009442 active site 426355009443 non-prolyl cis peptide bond; other site 426355009444 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 426355009445 V-type ATP synthase subunit E; Provisional; Region: PRK02292 426355009446 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 426355009447 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426355009448 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355009449 membrane-bound complex binding site; other site 426355009450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 426355009451 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426355009452 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426355009453 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426355009454 Walker A/P-loop; other site 426355009455 ATP binding site [chemical binding]; other site 426355009456 Q-loop/lid; other site 426355009457 ABC transporter signature motif; other site 426355009458 Walker B; other site 426355009459 D-loop; other site 426355009460 H-loop/switch region; other site 426355009461 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 426355009462 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 426355009463 O-Antigen ligase; Region: Wzy_C; pfam04932 426355009464 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 426355009465 Protein of unknown function, DUF393; Region: DUF393; pfam04134 426355009466 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 426355009467 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355009468 active site 426355009469 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 426355009470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355009471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355009472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 426355009473 dimerization interface [polypeptide binding]; other site 426355009474 hypothetical protein; Provisional; Region: PRK05463 426355009475 benzoate transport; Region: 2A0115; TIGR00895 426355009476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355009477 putative substrate translocation pore; other site 426355009478 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 426355009479 putative active site [active] 426355009480 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 426355009481 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 426355009482 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 426355009483 hypothetical protein; Provisional; Region: PRK06486 426355009484 intersubunit interface [polypeptide binding]; other site 426355009485 active site 426355009486 Zn2+ binding site [ion binding]; other site 426355009487 Transglycosylase SLT domain; Region: SLT_2; pfam13406 426355009488 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426355009489 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426355009490 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426355009491 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 426355009492 putative hydrophobic ligand binding site [chemical binding]; other site 426355009493 protein interface [polypeptide binding]; other site 426355009494 gate; other site 426355009495 pyruvate kinase; Provisional; Region: PRK06247 426355009496 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 426355009497 domain interfaces; other site 426355009498 active site 426355009499 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 426355009500 nucleophile elbow; other site 426355009501 GcrA cell cycle regulator; Region: GcrA; cl11564 426355009502 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 426355009503 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 426355009504 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 426355009505 dimer interface [polypeptide binding]; other site 426355009506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355009507 catalytic residue [active] 426355009508 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 426355009509 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 426355009510 G1 box; other site 426355009511 putative GEF interaction site [polypeptide binding]; other site 426355009512 GTP/Mg2+ binding site [chemical binding]; other site 426355009513 Switch I region; other site 426355009514 G2 box; other site 426355009515 G3 box; other site 426355009516 Switch II region; other site 426355009517 G4 box; other site 426355009518 G5 box; other site 426355009519 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 426355009520 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 426355009521 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 426355009522 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426355009523 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 426355009524 Q-loop/lid; other site 426355009525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355009526 ABC transporter signature motif; other site 426355009527 Walker B; other site 426355009528 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 426355009529 Cytochrome P450; Region: p450; cl12078 426355009530 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 426355009531 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 426355009532 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 426355009533 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 426355009534 Switch I; other site 426355009535 Switch II; other site 426355009536 septum formation inhibitor; Reviewed; Region: minC; PRK05177 426355009537 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 426355009538 septum formation inhibitor; Reviewed; Region: minC; PRK05177 426355009539 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 426355009540 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 426355009541 Family description; Region: UvrD_C_2; pfam13538 426355009542 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 426355009543 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 426355009544 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 426355009545 catalytic residues [active] 426355009546 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 426355009547 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 426355009548 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 426355009549 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 426355009550 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 426355009551 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 426355009552 substrate binding site [chemical binding]; other site 426355009553 active site 426355009554 catalytic residues [active] 426355009555 heterodimer interface [polypeptide binding]; other site 426355009556 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 426355009557 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 426355009558 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 426355009559 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 426355009560 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355009561 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426355009562 Predicted dehydrogenase [General function prediction only]; Region: COG0579 426355009563 LrgB-like family; Region: LrgB; pfam04172 426355009564 LrgA family; Region: LrgA; pfam03788 426355009565 Tellurite resistance protein TerB; Region: TerB; pfam05099 426355009566 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 426355009567 conserved cys residue [active] 426355009568 Putative transcription activator [Transcription]; Region: TenA; COG0819 426355009569 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426355009570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355009571 active site 426355009572 phosphorylation site [posttranslational modification] 426355009573 intermolecular recognition site; other site 426355009574 dimerization interface [polypeptide binding]; other site 426355009575 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355009576 DNA binding residues [nucleotide binding] 426355009577 dimerization interface [polypeptide binding]; other site 426355009578 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 426355009579 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355009580 dimerization interface [polypeptide binding]; other site 426355009581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355009582 ATP binding site [chemical binding]; other site 426355009583 Mg2+ binding site [ion binding]; other site 426355009584 G-X-G motif; other site 426355009585 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 426355009586 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 426355009587 ATP binding site [chemical binding]; other site 426355009588 putative Mg++ binding site [ion binding]; other site 426355009589 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426355009590 nucleotide binding region [chemical binding]; other site 426355009591 ATP-binding site [chemical binding]; other site 426355009592 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 426355009593 RNA binding site [nucleotide binding]; other site 426355009594 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 426355009595 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 426355009596 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 426355009597 FAD binding pocket [chemical binding]; other site 426355009598 conserved FAD binding motif [chemical binding]; other site 426355009599 phosphate binding motif [ion binding]; other site 426355009600 beta-alpha-beta structure motif; other site 426355009601 NAD binding pocket [chemical binding]; other site 426355009602 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 426355009603 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 426355009604 Moco binding site; other site 426355009605 metal coordination site [ion binding]; other site 426355009606 EamA-like transporter family; Region: EamA; pfam00892 426355009607 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 426355009608 EamA-like transporter family; Region: EamA; pfam00892 426355009609 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 426355009610 rRNA binding site [nucleotide binding]; other site 426355009611 predicted 30S ribosome binding site; other site 426355009612 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 426355009613 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426355009614 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 426355009615 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426355009616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355009617 homodimer interface [polypeptide binding]; other site 426355009618 catalytic residue [active] 426355009619 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 426355009620 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 426355009621 ligand binding site [chemical binding]; other site 426355009622 NAD binding site [chemical binding]; other site 426355009623 dimerization interface [polypeptide binding]; other site 426355009624 catalytic site [active] 426355009625 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 426355009626 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426355009627 N-terminal plug; other site 426355009628 ligand-binding site [chemical binding]; other site 426355009629 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 426355009630 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 426355009631 Transcriptional regulators [Transcription]; Region: PurR; COG1609 426355009632 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 426355009633 DNA binding site [nucleotide binding] 426355009634 domain linker motif; other site 426355009635 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426355009636 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 426355009637 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 426355009638 phosphate binding site [ion binding]; other site 426355009639 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 426355009640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355009641 D-galactonate transporter; Region: 2A0114; TIGR00893 426355009642 putative substrate translocation pore; other site 426355009643 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355009644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355009645 NAD(P) binding site [chemical binding]; other site 426355009646 active site 426355009647 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 426355009648 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 426355009649 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 426355009650 ABC1 family; Region: ABC1; cl17513 426355009651 PAS fold; Region: PAS_4; pfam08448 426355009652 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355009653 putative active site [active] 426355009654 heme pocket [chemical binding]; other site 426355009655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355009656 HWE histidine kinase; Region: HWE_HK; cl06527 426355009657 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 426355009658 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 426355009659 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 426355009660 Walker A/P-loop; other site 426355009661 ATP binding site [chemical binding]; other site 426355009662 Q-loop/lid; other site 426355009663 ABC transporter signature motif; other site 426355009664 Walker B; other site 426355009665 D-loop; other site 426355009666 H-loop/switch region; other site 426355009667 hypothetical protein; Provisional; Region: PRK10316 426355009668 YfdX protein; Region: YfdX; pfam10938 426355009669 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355009670 dimer interface [polypeptide binding]; other site 426355009671 phosphorylation site [posttranslational modification] 426355009672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355009673 ATP binding site [chemical binding]; other site 426355009674 Mg2+ binding site [ion binding]; other site 426355009675 G-X-G motif; other site 426355009676 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 426355009677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355009678 active site 426355009679 phosphorylation site [posttranslational modification] 426355009680 intermolecular recognition site; other site 426355009681 dimerization interface [polypeptide binding]; other site 426355009682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355009683 Walker A motif; other site 426355009684 ATP binding site [chemical binding]; other site 426355009685 Walker B motif; other site 426355009686 arginine finger; other site 426355009687 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 426355009688 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426355009689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355009690 putative substrate translocation pore; other site 426355009691 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 426355009692 active site 426355009693 homodimer interface [polypeptide binding]; other site 426355009694 homotetramer interface [polypeptide binding]; other site 426355009695 6-phosphogluconate dehydratase; Region: edd; TIGR01196 426355009696 phosphogluconate dehydratase; Validated; Region: PRK09054 426355009697 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 426355009698 active site 426355009699 intersubunit interface [polypeptide binding]; other site 426355009700 catalytic residue [active] 426355009701 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 426355009702 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 426355009703 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 426355009704 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 426355009705 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 426355009706 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 426355009707 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 426355009708 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 426355009709 active site 426355009710 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 426355009711 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 426355009712 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 426355009713 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 426355009714 trimer interface [polypeptide binding]; other site 426355009715 active site 426355009716 UDP-GlcNAc binding site [chemical binding]; other site 426355009717 lipid binding site [chemical binding]; lipid-binding site 426355009718 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 426355009719 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 426355009720 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 426355009721 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 426355009722 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 426355009723 Surface antigen; Region: Bac_surface_Ag; pfam01103 426355009724 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 426355009725 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 426355009726 active site 426355009727 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 426355009728 protein binding site [polypeptide binding]; other site 426355009729 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 426355009730 putative substrate binding region [chemical binding]; other site 426355009731 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 426355009732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355009733 putative substrate translocation pore; other site 426355009734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355009735 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 426355009736 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355009737 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355009738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426355009739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355009740 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 426355009741 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 426355009742 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 426355009743 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 426355009744 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 426355009745 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 426355009746 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 426355009747 ribosome recycling factor; Reviewed; Region: frr; PRK00083 426355009748 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 426355009749 hinge region; other site 426355009750 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 426355009751 putative nucleotide binding site [chemical binding]; other site 426355009752 uridine monophosphate binding site [chemical binding]; other site 426355009753 homohexameric interface [polypeptide binding]; other site 426355009754 elongation factor Ts; Provisional; Region: tsf; PRK09377 426355009755 UBA/TS-N domain; Region: UBA; pfam00627 426355009756 Elongation factor TS; Region: EF_TS; pfam00889 426355009757 Elongation factor TS; Region: EF_TS; pfam00889 426355009758 30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311 426355009759 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 426355009760 rRNA interaction site [nucleotide binding]; other site 426355009761 S8 interaction site; other site 426355009762 putative laminin-1 binding site; other site 426355009763 Uncharacterized conserved protein [Function unknown]; Region: COG3743 426355009764 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 426355009765 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426355009766 RNA binding surface [nucleotide binding]; other site 426355009767 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 426355009768 active site 426355009769 uracil binding [chemical binding]; other site 426355009770 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 426355009771 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355009772 S-adenosylmethionine binding site [chemical binding]; other site 426355009773 GTPase Era; Reviewed; Region: era; PRK00089 426355009774 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 426355009775 G1 box; other site 426355009776 GTP/Mg2+ binding site [chemical binding]; other site 426355009777 Switch I region; other site 426355009778 G2 box; other site 426355009779 Switch II region; other site 426355009780 G3 box; other site 426355009781 G4 box; other site 426355009782 G5 box; other site 426355009783 KH domain; Region: KH_2; pfam07650 426355009784 ribonuclease III; Reviewed; Region: rnc; PRK00102 426355009785 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 426355009786 dimerization interface [polypeptide binding]; other site 426355009787 active site 426355009788 metal binding site [ion binding]; metal-binding site 426355009789 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 426355009790 dsRNA binding site [nucleotide binding]; other site 426355009791 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 426355009792 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 426355009793 Catalytic site [active] 426355009794 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 426355009795 Catalytic site [active] 426355009796 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 426355009797 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 426355009798 active site 426355009799 hydrophilic channel; other site 426355009800 dimerization interface [polypeptide binding]; other site 426355009801 catalytic residues [active] 426355009802 active site lid [active] 426355009803 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 426355009804 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 426355009805 TPP-binding site; other site 426355009806 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 426355009807 PYR/PP interface [polypeptide binding]; other site 426355009808 dimer interface [polypeptide binding]; other site 426355009809 TPP binding site [chemical binding]; other site 426355009810 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 426355009811 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 426355009812 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 426355009813 active site 426355009814 substrate binding site [chemical binding]; other site 426355009815 Mg2+ binding site [ion binding]; other site 426355009816 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 426355009817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355009818 Walker A/P-loop; other site 426355009819 ATP binding site [chemical binding]; other site 426355009820 Q-loop/lid; other site 426355009821 ABC transporter signature motif; other site 426355009822 Walker B; other site 426355009823 D-loop; other site 426355009824 H-loop/switch region; other site 426355009825 ABC transporter; Region: ABC_tran_2; pfam12848 426355009826 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426355009827 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355009828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355009829 NAD(P) binding site [chemical binding]; other site 426355009830 active site 426355009831 OpgC protein; Region: OpgC_C; pfam10129 426355009832 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 426355009833 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 426355009834 Ligand binding site; other site 426355009835 metal-binding site 426355009836 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 426355009837 putative MPT binding site; other site 426355009838 XdhC Rossmann domain; Region: XdhC_C; pfam13478 426355009839 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 426355009840 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 426355009841 HAMP domain; Region: HAMP; pfam00672 426355009842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355009843 dimer interface [polypeptide binding]; other site 426355009844 phosphorylation site [posttranslational modification] 426355009845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355009846 ATP binding site [chemical binding]; other site 426355009847 Mg2+ binding site [ion binding]; other site 426355009848 G-X-G motif; other site 426355009849 aspartate aminotransferase; Provisional; Region: PRK05764 426355009850 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426355009851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355009852 homodimer interface [polypeptide binding]; other site 426355009853 catalytic residue [active] 426355009854 Novel bacterial esterase 713 that cleaves esters on halogenated cyclic compounds; Region: Esterase_713; cd12807 426355009855 catalytic site [active] 426355009856 Protein of unknown function (DUF533); Region: DUF533; pfam04391 426355009857 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 426355009858 putative metal binding site [ion binding]; other site 426355009859 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 426355009860 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 426355009861 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 426355009862 membrane ATPase/protein kinase; Provisional; Region: PRK09435 426355009863 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 426355009864 Walker A; other site 426355009865 CsbD-like; Region: CsbD; pfam05532 426355009866 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 426355009867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355009868 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 426355009869 NAD(P) binding site [chemical binding]; other site 426355009870 active site 426355009871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355009872 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355009873 dimerization interface [polypeptide binding]; other site 426355009874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355009875 dimer interface [polypeptide binding]; other site 426355009876 phosphorylation site [posttranslational modification] 426355009877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355009878 ATP binding site [chemical binding]; other site 426355009879 Mg2+ binding site [ion binding]; other site 426355009880 G-X-G motif; other site 426355009881 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355009882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355009883 active site 426355009884 phosphorylation site [posttranslational modification] 426355009885 intermolecular recognition site; other site 426355009886 dimerization interface [polypeptide binding]; other site 426355009887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355009888 DNA binding site [nucleotide binding] 426355009889 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 426355009890 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 426355009891 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 426355009892 minor groove reading motif; other site 426355009893 helix-hairpin-helix signature motif; other site 426355009894 substrate binding pocket [chemical binding]; other site 426355009895 active site 426355009896 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 426355009897 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 426355009898 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 426355009899 ATP binding site [chemical binding]; other site 426355009900 active site 426355009901 substrate binding site [chemical binding]; other site 426355009902 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 426355009903 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 426355009904 Probable Catalytic site; other site 426355009905 metal-binding site 426355009906 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 426355009907 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 426355009908 Probable Catalytic site; other site 426355009909 metal-binding site 426355009910 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 426355009911 Protein of unknown function DUF45; Region: DUF45; pfam01863 426355009912 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 426355009913 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 426355009914 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 426355009915 hypothetical protein; Validated; Region: PRK06201 426355009916 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 426355009917 cell density-dependent motility repressor; Provisional; Region: PRK10082 426355009918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355009919 LysR substrate binding domain; Region: LysR_substrate; pfam03466 426355009920 dimerization interface [polypeptide binding]; other site 426355009921 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 426355009922 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 426355009923 putative active site pocket [active] 426355009924 metal binding site [ion binding]; metal-binding site 426355009925 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 426355009926 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426355009927 active site 426355009928 metal binding site [ion binding]; metal-binding site 426355009929 Protein of unknown function (DUF423); Region: DUF423; cl01008 426355009930 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 426355009931 G1 box; other site 426355009932 GTP/Mg2+ binding site [chemical binding]; other site 426355009933 Switch I region; other site 426355009934 G2 box; other site 426355009935 G3 box; other site 426355009936 Switch II region; other site 426355009937 G4 box; other site 426355009938 G5 box; other site 426355009939 membrane protein insertase; Provisional; Region: PRK01318 426355009940 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 426355009941 Ribonuclease P; Region: Ribonuclease_P; pfam00825 426355009942 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 426355009943 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426355009944 active site 426355009945 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 426355009946 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 426355009947 active site 426355009948 dimerization interface [polypeptide binding]; other site 426355009949 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 426355009950 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 426355009951 substrate-cofactor binding pocket; other site 426355009952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355009953 catalytic residue [active] 426355009954 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 426355009955 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 426355009956 hinge; other site 426355009957 active site 426355009958 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 426355009959 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 426355009960 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 426355009961 NAD binding site [chemical binding]; other site 426355009962 dimerization interface [polypeptide binding]; other site 426355009963 product binding site; other site 426355009964 substrate binding site [chemical binding]; other site 426355009965 zinc binding site [ion binding]; other site 426355009966 catalytic residues [active] 426355009967 hypothetical protein; Provisional; Region: PRK02853 426355009968 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 426355009969 Low molecular weight phosphatase family; Region: LMWPc; cd00115 426355009970 active site 426355009971 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 426355009972 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 426355009973 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 426355009974 Uncharacterized conserved protein [Function unknown]; Region: COG3287 426355009975 FIST N domain; Region: FIST; pfam08495 426355009976 FIST C domain; Region: FIST_C; pfam10442 426355009977 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355009978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355009979 dimer interface [polypeptide binding]; other site 426355009980 phosphorylation site [posttranslational modification] 426355009981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355009982 ATP binding site [chemical binding]; other site 426355009983 Mg2+ binding site [ion binding]; other site 426355009984 G-X-G motif; other site 426355009985 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355009986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355009987 active site 426355009988 phosphorylation site [posttranslational modification] 426355009989 intermolecular recognition site; other site 426355009990 dimerization interface [polypeptide binding]; other site 426355009991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355009992 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426355009993 putative substrate translocation pore; other site 426355009994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355009995 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426355009996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355009997 NAD(P) binding site [chemical binding]; other site 426355009998 active site 426355009999 SWIB/MDM2 domain; Region: SWIB; pfam02201 426355010000 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 426355010001 PRC-barrel domain; Region: PRC; pfam05239 426355010002 PRC-barrel domain; Region: PRC; pfam05239 426355010003 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426355010004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355010005 putative substrate translocation pore; other site 426355010006 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 426355010007 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426355010008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355010009 Walker A/P-loop; other site 426355010010 ATP binding site [chemical binding]; other site 426355010011 Q-loop/lid; other site 426355010012 ABC transporter signature motif; other site 426355010013 Walker B; other site 426355010014 D-loop; other site 426355010015 H-loop/switch region; other site 426355010016 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 426355010017 glutaminase; Provisional; Region: PRK00971 426355010018 benzoate transport; Region: 2A0115; TIGR00895 426355010019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355010020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355010021 putative substrate translocation pore; other site 426355010022 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 426355010023 putative active site [active] 426355010024 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 426355010025 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 426355010026 substrate binding site [chemical binding]; other site 426355010027 ATP binding site [chemical binding]; other site 426355010028 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426355010029 HAMP domain; Region: HAMP; pfam00672 426355010030 dimerization interface [polypeptide binding]; other site 426355010031 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355010032 dimer interface [polypeptide binding]; other site 426355010033 putative CheW interface [polypeptide binding]; other site 426355010034 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 426355010035 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 426355010036 NAD(P) binding site [chemical binding]; other site 426355010037 PAS fold; Region: PAS_4; pfam08448 426355010038 PAS domain S-box; Region: sensory_box; TIGR00229 426355010039 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355010040 putative active site [active] 426355010041 heme pocket [chemical binding]; other site 426355010042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355010043 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355010044 dimer interface [polypeptide binding]; other site 426355010045 phosphorylation site [posttranslational modification] 426355010046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355010047 ATP binding site [chemical binding]; other site 426355010048 Mg2+ binding site [ion binding]; other site 426355010049 G-X-G motif; other site 426355010050 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355010051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355010052 active site 426355010053 phosphorylation site [posttranslational modification] 426355010054 intermolecular recognition site; other site 426355010055 dimerization interface [polypeptide binding]; other site 426355010056 5'-3' exonuclease; Region: 53EXOc; smart00475 426355010057 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 426355010058 active site 426355010059 metal binding site 1 [ion binding]; metal-binding site 426355010060 putative 5' ssDNA interaction site; other site 426355010061 metal binding site 3; metal-binding site 426355010062 metal binding site 2 [ion binding]; metal-binding site 426355010063 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 426355010064 putative DNA binding site [nucleotide binding]; other site 426355010065 putative metal binding site [ion binding]; other site 426355010066 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 426355010067 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 426355010068 active site 426355010069 catalytic site [active] 426355010070 substrate binding site [chemical binding]; other site 426355010071 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 426355010072 active site 426355010073 DNA binding site [nucleotide binding] 426355010074 catalytic site [active] 426355010075 Protein of unknown function DUF86; Region: DUF86; cl01031 426355010076 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 426355010077 active site 426355010078 NTP binding site [chemical binding]; other site 426355010079 metal binding triad [ion binding]; metal-binding site 426355010080 antibiotic binding site [chemical binding]; other site 426355010081 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 426355010082 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 426355010083 Fe-S cluster binding site [ion binding]; other site 426355010084 active site 426355010085 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 426355010086 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355010087 FeS/SAM binding site; other site 426355010088 RecX family; Region: RecX; cl00936 426355010089 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 426355010090 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 426355010091 PII uridylyl-transferase; Provisional; Region: PRK05092 426355010092 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 426355010093 metal binding triad; other site 426355010094 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 426355010095 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426355010096 Zn2+ binding site [ion binding]; other site 426355010097 Mg2+ binding site [ion binding]; other site 426355010098 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 426355010099 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 426355010100 GrpE; Region: GrpE; pfam01025 426355010101 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 426355010102 dimer interface [polypeptide binding]; other site 426355010103 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 426355010104 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 426355010105 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 426355010106 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 426355010107 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 426355010108 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 426355010109 DNA binding site [nucleotide binding] 426355010110 active site 426355010111 DHHW protein; Region: DHHW; pfam14286 426355010112 hypothetical protein; Validated; Region: PRK00110 426355010113 short chain dehydrogenase; Provisional; Region: PRK07109 426355010114 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 426355010115 putative NAD(P) binding site [chemical binding]; other site 426355010116 active site 426355010117 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 426355010118 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426355010119 motif II; other site 426355010120 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 426355010121 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 426355010122 substrate binding site [chemical binding]; other site 426355010123 hexamer interface [polypeptide binding]; other site 426355010124 metal binding site [ion binding]; metal-binding site 426355010125 phosphoribulokinase; Provisional; Region: PRK15453 426355010126 active site 426355010127 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 426355010128 metal binding site [ion binding]; metal-binding site 426355010129 active site 426355010130 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355010131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355010132 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 426355010133 putative dimerization interface [polypeptide binding]; other site 426355010134 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 426355010135 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426355010136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355010137 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426355010138 putative substrate translocation pore; other site 426355010139 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355010140 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426355010141 substrate binding pocket [chemical binding]; other site 426355010142 membrane-bound complex binding site; other site 426355010143 hinge residues; other site 426355010144 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 426355010145 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426355010146 putative C-terminal domain interface [polypeptide binding]; other site 426355010147 putative GSH binding site (G-site) [chemical binding]; other site 426355010148 putative dimer interface [polypeptide binding]; other site 426355010149 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 426355010150 dimer interface [polypeptide binding]; other site 426355010151 N-terminal domain interface [polypeptide binding]; other site 426355010152 putative substrate binding pocket (H-site) [chemical binding]; other site 426355010153 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355010154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355010155 active site 426355010156 phosphorylation site [posttranslational modification] 426355010157 intermolecular recognition site; other site 426355010158 dimerization interface [polypeptide binding]; other site 426355010159 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 426355010160 histidine kinase; Provisional; Region: PRK13557 426355010161 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355010162 putative active site [active] 426355010163 heme pocket [chemical binding]; other site 426355010164 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355010165 dimer interface [polypeptide binding]; other site 426355010166 phosphorylation site [posttranslational modification] 426355010167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355010168 ATP binding site [chemical binding]; other site 426355010169 Mg2+ binding site [ion binding]; other site 426355010170 G-X-G motif; other site 426355010171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355010172 active site 426355010173 phosphorylation site [posttranslational modification] 426355010174 intermolecular recognition site; other site 426355010175 dimerization interface [polypeptide binding]; other site 426355010176 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 426355010177 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 426355010178 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 426355010179 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 426355010180 FAD binding domain; Region: FAD_binding_4; pfam01565 426355010181 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 426355010182 ribonuclease R; Region: RNase_R; TIGR02063 426355010183 RNB domain; Region: RNB; pfam00773 426355010184 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 426355010185 RNA binding site [nucleotide binding]; other site 426355010186 Protein of unknown function (DUF983); Region: DUF983; cl02211 426355010187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355010188 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426355010189 putative substrate translocation pore; other site 426355010190 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 426355010191 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355010192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355010193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 426355010194 dimerization interface [polypeptide binding]; other site 426355010195 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 426355010196 aconitate hydratase; Validated; Region: PRK09277 426355010197 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 426355010198 substrate binding site [chemical binding]; other site 426355010199 ligand binding site [chemical binding]; other site 426355010200 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 426355010201 substrate binding site [chemical binding]; other site 426355010202 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 426355010203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426355010204 binding surface 426355010205 TPR motif; other site 426355010206 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 426355010207 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 426355010208 interface (dimer of trimers) [polypeptide binding]; other site 426355010209 Substrate-binding/catalytic site; other site 426355010210 Zn-binding sites [ion binding]; other site 426355010211 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 426355010212 Chromate transporter; Region: Chromate_transp; pfam02417 426355010213 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 426355010214 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 426355010215 metal binding site [ion binding]; metal-binding site 426355010216 putative dimer interface [polypeptide binding]; other site 426355010217 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 426355010218 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 426355010219 DNA binding residues [nucleotide binding] 426355010220 dimer interface [polypeptide binding]; other site 426355010221 copper binding site [ion binding]; other site 426355010222 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 426355010223 metal-binding site [ion binding] 426355010224 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 426355010225 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 426355010226 metal-binding site [ion binding] 426355010227 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 426355010228 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 426355010229 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426355010230 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 426355010231 putative C-terminal domain interface [polypeptide binding]; other site 426355010232 putative GSH binding site (G-site) [chemical binding]; other site 426355010233 putative dimer interface [polypeptide binding]; other site 426355010234 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 426355010235 N-terminal domain interface [polypeptide binding]; other site 426355010236 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 426355010237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355010238 dimer interface [polypeptide binding]; other site 426355010239 phosphorylation site [posttranslational modification] 426355010240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355010241 ATP binding site [chemical binding]; other site 426355010242 Mg2+ binding site [ion binding]; other site 426355010243 G-X-G motif; other site 426355010244 Predicted integral membrane protein [Function unknown]; Region: COG0392 426355010245 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 426355010246 ligand binding site [chemical binding]; other site 426355010247 active site 426355010248 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 426355010249 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355010250 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 426355010251 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 426355010252 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 426355010253 Metal-binding active site; metal-binding site 426355010254 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 426355010255 YcaO-like family; Region: YcaO; pfam02624 426355010256 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 426355010257 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 426355010258 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 426355010259 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426355010260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355010261 S-adenosylmethionine binding site [chemical binding]; other site 426355010262 HD domain; Region: HD_3; cl17350 426355010263 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 426355010264 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426355010265 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426355010266 catalytic residue [active] 426355010267 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 426355010268 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 426355010269 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 426355010270 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 426355010271 EF-hand domain pair; Region: EF_hand_5; pfam13499 426355010272 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 426355010273 Ca2+ binding site [ion binding]; other site 426355010274 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 426355010275 Ca2+ binding site [ion binding]; other site 426355010276 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 426355010277 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 426355010278 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 426355010279 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 426355010280 Transglycosylase; Region: Transgly; pfam00912 426355010281 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 426355010282 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 426355010283 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 426355010284 HlyD family secretion protein; Region: HlyD; pfam00529 426355010285 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355010286 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355010287 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 426355010288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355010289 putative substrate translocation pore; other site 426355010290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355010291 RimM N-terminal domain; Region: RimM; pfam01782 426355010292 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 426355010293 PRC-barrel domain; Region: PRC; pfam05239 426355010294 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 426355010295 chorismate mutase; Provisional; Region: PRK09239 426355010296 signal recognition particle protein; Provisional; Region: PRK10867 426355010297 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 426355010298 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 426355010299 P loop; other site 426355010300 GTP binding site [chemical binding]; other site 426355010301 Signal peptide binding domain; Region: SRP_SPB; pfam02978 426355010302 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 426355010303 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 426355010304 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 426355010305 [2Fe-2S] cluster binding site [ion binding]; other site 426355010306 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 426355010307 hydrophobic ligand binding site; other site 426355010308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355010309 S-adenosylmethionine binding site [chemical binding]; other site 426355010310 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 426355010311 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 426355010312 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426355010313 catalytic residue [active] 426355010314 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 426355010315 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 426355010316 Nitrogen regulatory protein P-II; Region: P-II; smart00938 426355010317 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 426355010318 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 426355010319 active site 426355010320 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 426355010321 catalytic triad [active] 426355010322 dimer interface [polypeptide binding]; other site 426355010323 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 426355010324 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 426355010325 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 426355010326 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 426355010327 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355010328 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 426355010329 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355010330 active site 426355010331 Rhamnan synthesis protein F; Region: RgpF; pfam05045 426355010332 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426355010333 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355010334 MoxR-like ATPases [General function prediction only]; Region: COG0714 426355010335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 426355010336 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 426355010337 Protein of unknown function DUF58; Region: DUF58; pfam01882 426355010338 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 426355010339 conserved cys residue [active] 426355010340 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 426355010341 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 426355010342 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 426355010343 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 426355010344 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 426355010345 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 426355010346 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 426355010347 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 426355010348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355010349 dimer interface [polypeptide binding]; other site 426355010350 conserved gate region; other site 426355010351 putative PBP binding loops; other site 426355010352 ABC-ATPase subunit interface; other site 426355010353 Transcriptional regulator; Region: Rrf2; cl17282 426355010354 Rrf2 family protein; Region: rrf2_super; TIGR00738 426355010355 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 426355010356 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 426355010357 heme-binding site [chemical binding]; other site 426355010358 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 426355010359 FAD binding pocket [chemical binding]; other site 426355010360 FAD binding motif [chemical binding]; other site 426355010361 phosphate binding motif [ion binding]; other site 426355010362 beta-alpha-beta structure motif; other site 426355010363 NAD binding pocket [chemical binding]; other site 426355010364 Heme binding pocket [chemical binding]; other site 426355010365 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 426355010366 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 426355010367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355010368 putative substrate translocation pore; other site 426355010369 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426355010370 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 426355010371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426355010372 Coenzyme A binding pocket [chemical binding]; other site 426355010373 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 426355010374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355010375 putative substrate translocation pore; other site 426355010376 Cytochrome c2 [Energy production and conversion]; Region: COG3474 426355010377 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 426355010378 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 426355010379 Ligand binding site; other site 426355010380 oligomer interface; other site 426355010381 prephenate dehydratase; Provisional; Region: PRK11899 426355010382 Prephenate dehydratase; Region: PDT; pfam00800 426355010383 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 426355010384 putative L-Phe binding site [chemical binding]; other site 426355010385 Putative phosphatase (DUF442); Region: DUF442; cl17385 426355010386 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 426355010387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426355010388 Coenzyme A binding pocket [chemical binding]; other site 426355010389 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 426355010390 dimer interface [polypeptide binding]; other site 426355010391 substrate binding site [chemical binding]; other site 426355010392 metal binding sites [ion binding]; metal-binding site 426355010393 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 426355010394 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 426355010395 trimer interface [polypeptide binding]; other site 426355010396 putative metal binding site [ion binding]; other site 426355010397 META domain; Region: META; pfam03724 426355010398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 426355010399 non-specific DNA binding site [nucleotide binding]; other site 426355010400 salt bridge; other site 426355010401 sequence-specific DNA binding site [nucleotide binding]; other site 426355010402 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 426355010403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426355010404 S-adenosylmethionine binding site [chemical binding]; other site 426355010405 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 426355010406 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355010407 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 426355010408 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 426355010409 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 426355010410 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 426355010411 CoA binding domain; Region: CoA_binding; pfam02629 426355010412 CoA-ligase; Region: Ligase_CoA; pfam00549 426355010413 malate--CoA ligase subunit beta; Provisional; Region: PRK14046 426355010414 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 426355010415 CoA-ligase; Region: Ligase_CoA; pfam00549 426355010416 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 426355010417 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 426355010418 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 426355010419 NADP binding site [chemical binding]; other site 426355010420 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 426355010421 glycerate dehydrogenase; Provisional; Region: PRK06487 426355010422 putative ligand binding site [chemical binding]; other site 426355010423 putative NAD binding site [chemical binding]; other site 426355010424 catalytic site [active] 426355010425 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 426355010426 homodimer interface [polypeptide binding]; other site 426355010427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355010428 catalytic residue [active] 426355010429 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426355010430 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 426355010431 putative active site [active] 426355010432 putative metal binding site [ion binding]; other site 426355010433 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 426355010434 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 426355010435 RNA/DNA hybrid binding site [nucleotide binding]; other site 426355010436 active site 426355010437 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355010438 dimerization interface [polypeptide binding]; other site 426355010439 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426355010440 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 426355010441 amino acid transporter; Region: 2A0306; TIGR00909 426355010442 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 426355010443 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 426355010444 MPT binding site; other site 426355010445 trimer interface [polypeptide binding]; other site 426355010446 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 426355010447 maleylacetoacetate isomerase; Region: maiA; TIGR01262 426355010448 C-terminal domain interface [polypeptide binding]; other site 426355010449 GSH binding site (G-site) [chemical binding]; other site 426355010450 putative dimer interface [polypeptide binding]; other site 426355010451 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 426355010452 dimer interface [polypeptide binding]; other site 426355010453 N-terminal domain interface [polypeptide binding]; other site 426355010454 substrate binding pocket (H-site) [chemical binding]; other site 426355010455 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 426355010456 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426355010457 EthD domain; Region: EthD; cl17553 426355010458 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426355010459 GAF domain; Region: GAF; pfam01590 426355010460 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355010461 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 426355010462 putative active site [active] 426355010463 heme pocket [chemical binding]; other site 426355010464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355010465 dimer interface [polypeptide binding]; other site 426355010466 phosphorylation site [posttranslational modification] 426355010467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355010468 ATP binding site [chemical binding]; other site 426355010469 Mg2+ binding site [ion binding]; other site 426355010470 G-X-G motif; other site 426355010471 Response regulator receiver domain; Region: Response_reg; pfam00072 426355010472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355010473 active site 426355010474 phosphorylation site [posttranslational modification] 426355010475 intermolecular recognition site; other site 426355010476 dimerization interface [polypeptide binding]; other site 426355010477 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 426355010478 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 426355010479 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 426355010480 P-loop, Walker A motif; other site 426355010481 Base recognition motif; other site 426355010482 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 426355010483 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426355010484 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 426355010485 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355010486 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 426355010487 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 426355010488 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 426355010489 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 426355010490 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 426355010491 DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120 426355010492 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 426355010493 active site 426355010494 DNA binding site [nucleotide binding] 426355010495 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 426355010496 DNA binding site [nucleotide binding] 426355010497 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 426355010498 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 426355010499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355010500 S-adenosylmethionine binding site [chemical binding]; other site 426355010501 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 426355010502 hypothetical protein; Provisional; Region: PRK09256 426355010503 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 426355010504 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 426355010505 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 426355010506 HSP70 interaction site [polypeptide binding]; other site 426355010507 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 426355010508 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 426355010509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 426355010510 Domain of unknown function DUF29; Region: DUF29; pfam01724 426355010511 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 426355010512 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 426355010513 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 426355010514 metal ion-dependent adhesion site (MIDAS); other site 426355010515 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 426355010516 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 426355010517 Uncharacterized conserved protein [Function unknown]; Region: COG5470 426355010518 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426355010519 nucleotide binding region [chemical binding]; other site 426355010520 ATP-binding site [chemical binding]; other site 426355010521 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426355010522 RNA binding surface [nucleotide binding]; other site 426355010523 Ferredoxin [Energy production and conversion]; Region: COG1146 426355010524 4Fe-4S binding domain; Region: Fer4; pfam00037 426355010525 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 426355010526 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 426355010527 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 426355010528 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355010529 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426355010530 DNA binding residues [nucleotide binding] 426355010531 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426355010532 preprotein translocase subunit SecB; Validated; Region: PRK05751 426355010533 SecA binding site; other site 426355010534 Preprotein binding site; other site 426355010535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 426355010536 MltA specific insert domain; Region: MltA; smart00925 426355010537 3D domain; Region: 3D; pfam06725 426355010538 Smr domain; Region: Smr; pfam01713 426355010539 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 426355010540 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 426355010541 DNA binding site [nucleotide binding] 426355010542 catalytic residue [active] 426355010543 H2TH interface [polypeptide binding]; other site 426355010544 putative catalytic residues [active] 426355010545 turnover-facilitating residue; other site 426355010546 intercalation triad [nucleotide binding]; other site 426355010547 8OG recognition residue [nucleotide binding]; other site 426355010548 putative reading head residues; other site 426355010549 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 426355010550 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 426355010551 YceG-like family; Region: YceG; pfam02618 426355010552 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 426355010553 dimerization interface [polypeptide binding]; other site 426355010554 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355010555 putative active site [active] 426355010556 PAS fold; Region: PAS_3; pfam08447 426355010557 heme pocket [chemical binding]; other site 426355010558 hypothetical protein; Provisional; Region: PRK11820 426355010559 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 426355010560 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 426355010561 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 426355010562 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 426355010563 catalytic site [active] 426355010564 G-X2-G-X-G-K; other site 426355010565 Protein of unknown function, DUF606; Region: DUF606; pfam04657 426355010566 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 426355010567 heme binding pocket [chemical binding]; other site 426355010568 photoactive yellow protein; Region: photo_yellow; TIGR02373 426355010569 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 426355010570 GAF domain; Region: GAF; pfam01590 426355010571 Phytochrome region; Region: PHY; pfam00360 426355010572 Histidine kinase; Region: HisKA_2; pfam07568 426355010573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355010574 ATP binding site [chemical binding]; other site 426355010575 Mg2+ binding site [ion binding]; other site 426355010576 G-X-G motif; other site 426355010577 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 426355010578 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426355010579 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 426355010580 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 426355010581 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 426355010582 RNA binding site [nucleotide binding]; other site 426355010583 active site 426355010584 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 426355010585 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 426355010586 translation initiation factor IF-2; Region: IF-2; TIGR00487 426355010587 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 426355010588 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 426355010589 G1 box; other site 426355010590 putative GEF interaction site [polypeptide binding]; other site 426355010591 GTP/Mg2+ binding site [chemical binding]; other site 426355010592 Switch I region; other site 426355010593 G2 box; other site 426355010594 G3 box; other site 426355010595 Switch II region; other site 426355010596 G4 box; other site 426355010597 G5 box; other site 426355010598 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 426355010599 Translation-initiation factor 2; Region: IF-2; pfam11987 426355010600 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 426355010601 hypothetical protein; Provisional; Region: PRK09190 426355010602 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 426355010603 putative RNA binding cleft [nucleotide binding]; other site 426355010604 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 426355010605 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 426355010606 NusA N-terminal domain; Region: NusA_N; pfam08529 426355010607 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 426355010608 RNA binding site [nucleotide binding]; other site 426355010609 homodimer interface [polypeptide binding]; other site 426355010610 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 426355010611 G-X-X-G motif; other site 426355010612 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 426355010613 G-X-X-G motif; other site 426355010614 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 426355010615 ribosome maturation protein RimP; Reviewed; Region: PRK00092 426355010616 Sm and related proteins; Region: Sm_like; cl00259 426355010617 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 426355010618 putative oligomer interface [polypeptide binding]; other site 426355010619 putative RNA binding site [nucleotide binding]; other site 426355010620 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426355010621 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426355010622 active site 426355010623 catalytic tetrad [active] 426355010624 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 426355010625 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 426355010626 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 426355010627 Prostaglandin dehydrogenases; Region: PGDH; cd05288 426355010628 NAD(P) binding site [chemical binding]; other site 426355010629 substrate binding site [chemical binding]; other site 426355010630 dimer interface [polypeptide binding]; other site 426355010631 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 426355010632 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 426355010633 dimer interface [polypeptide binding]; other site 426355010634 ssDNA binding site [nucleotide binding]; other site 426355010635 tetramer (dimer of dimers) interface [polypeptide binding]; other site 426355010636 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426355010637 classical (c) SDRs; Region: SDR_c; cd05233 426355010638 NAD(P) binding site [chemical binding]; other site 426355010639 active site 426355010640 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 426355010641 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 426355010642 putative molybdopterin cofactor binding site [chemical binding]; other site 426355010643 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 426355010644 putative molybdopterin cofactor binding site; other site 426355010645 short chain dehydrogenase; Provisional; Region: PRK06701 426355010646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355010647 NAD(P) binding site [chemical binding]; other site 426355010648 active site 426355010649 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 426355010650 putative catalytic site [active] 426355010651 putative phosphate binding site [ion binding]; other site 426355010652 active site 426355010653 metal binding site A [ion binding]; metal-binding site 426355010654 DNA binding site [nucleotide binding] 426355010655 putative AP binding site [nucleotide binding]; other site 426355010656 putative metal binding site B [ion binding]; other site 426355010657 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 426355010658 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 426355010659 putative acyl-acceptor binding pocket; other site 426355010660 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 426355010661 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 426355010662 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 426355010663 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 426355010664 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 426355010665 NAD synthetase; Reviewed; Region: nadE; PRK02628 426355010666 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 426355010667 multimer interface [polypeptide binding]; other site 426355010668 active site 426355010669 catalytic triad [active] 426355010670 protein interface 1 [polypeptide binding]; other site 426355010671 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 426355010672 homodimer interface [polypeptide binding]; other site 426355010673 NAD binding pocket [chemical binding]; other site 426355010674 ATP binding pocket [chemical binding]; other site 426355010675 Mg binding site [ion binding]; other site 426355010676 active-site loop [active] 426355010677 PilZ domain; Region: PilZ; pfam07238 426355010678 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 426355010679 HIT family signature motif; other site 426355010680 catalytic residue [active] 426355010681 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 426355010682 Cation efflux family; Region: Cation_efflux; pfam01545 426355010683 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355010684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355010685 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 426355010686 putative effector binding pocket; other site 426355010687 dimerization interface [polypeptide binding]; other site 426355010688 classical (c) SDRs; Region: SDR_c; cd05233 426355010689 NAD(P) binding site [chemical binding]; other site 426355010690 active site 426355010691 short chain dehydrogenase; Provisional; Region: PRK06197 426355010692 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 426355010693 putative NAD(P) binding site [chemical binding]; other site 426355010694 active site 426355010695 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 426355010696 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 426355010697 putative ion selectivity filter; other site 426355010698 putative pore gating glutamate residue; other site 426355010699 putative H+/Cl- coupling transport residue; other site 426355010700 photolyase PhrII; Region: phr2; TIGR00591 426355010701 DNA photolyase; Region: DNA_photolyase; pfam00875 426355010702 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 426355010703 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 426355010704 active site 426355010705 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 426355010706 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 426355010707 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 426355010708 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 426355010709 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426355010710 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 426355010711 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 426355010712 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 426355010713 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 426355010714 AAA domain; Region: AAA_33; pfam13671 426355010715 ATP-binding site [chemical binding]; other site 426355010716 Gluconate-6-phosphate binding site [chemical binding]; other site 426355010717 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 426355010718 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 426355010719 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426355010720 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426355010721 catalytic residue [active] 426355010722 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 426355010723 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355010724 non-specific DNA binding site [nucleotide binding]; other site 426355010725 salt bridge; other site 426355010726 sequence-specific DNA binding site [nucleotide binding]; other site 426355010727 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 426355010728 ADP binding site [chemical binding]; other site 426355010729 magnesium binding site [ion binding]; other site 426355010730 putative shikimate binding site; other site 426355010731 serine acetyltransferase; Provisional; Region: cysE; PRK11132 426355010732 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 426355010733 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 426355010734 trimer interface [polypeptide binding]; other site 426355010735 active site 426355010736 substrate binding site [chemical binding]; other site 426355010737 CoA binding site [chemical binding]; other site 426355010738 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 426355010739 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 426355010740 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 426355010741 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 426355010742 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426355010743 acyl-activating enzyme (AAE) consensus motif; other site 426355010744 AMP binding site [chemical binding]; other site 426355010745 active site 426355010746 CoA binding site [chemical binding]; other site 426355010747 enoyl-CoA hydratase; Provisional; Region: PRK05862 426355010748 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426355010749 substrate binding site [chemical binding]; other site 426355010750 oxyanion hole (OAH) forming residues; other site 426355010751 trimer interface [polypeptide binding]; other site 426355010752 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426355010753 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 426355010754 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 426355010755 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426355010756 substrate binding site [chemical binding]; other site 426355010757 oxyanion hole (OAH) forming residues; other site 426355010758 trimer interface [polypeptide binding]; other site 426355010759 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 426355010760 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426355010761 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 426355010762 substrate binding pocket [chemical binding]; other site 426355010763 FAD binding site [chemical binding]; other site 426355010764 catalytic base [active] 426355010765 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 426355010766 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 426355010767 tetrameric interface [polypeptide binding]; other site 426355010768 NAD binding site [chemical binding]; other site 426355010769 catalytic residues [active] 426355010770 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355010771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355010772 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426355010773 dimerization interface [polypeptide binding]; other site 426355010774 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 426355010775 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 426355010776 active site 426355010777 NAD binding site [chemical binding]; other site 426355010778 metal binding site [ion binding]; metal-binding site 426355010779 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355010780 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426355010781 putative ligand binding site [chemical binding]; other site 426355010782 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 426355010783 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 426355010784 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 426355010785 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 426355010786 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 426355010787 Type IV pili component [Cell motility and secretion]; Region: COG5461 426355010788 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 426355010789 AAA domain; Region: AAA_31; pfam13614 426355010790 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 426355010791 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 426355010792 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 426355010793 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 426355010794 ATP binding site [chemical binding]; other site 426355010795 Walker A motif; other site 426355010796 hexamer interface [polypeptide binding]; other site 426355010797 Walker B motif; other site 426355010798 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 426355010799 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 426355010800 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 426355010801 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 426355010802 GcrA cell cycle regulator; Region: GcrA; cl11564 426355010803 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 426355010804 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 426355010805 active site residue [active] 426355010806 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 426355010807 active site residue [active] 426355010808 Iron permease FTR1 family; Region: FTR1; cl00475 426355010809 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 426355010810 4Fe-4S binding domain; Region: Fer4_5; pfam12801 426355010811 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 426355010812 Fe2+ transport protein; Region: Iron_transport; pfam10634 426355010813 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 426355010814 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 426355010815 lipoate-protein ligase B; Provisional; Region: PRK14341 426355010816 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 426355010817 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426355010818 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355010819 Predicted membrane protein [Function unknown]; Region: COG1297 426355010820 putative oligopeptide transporter, OPT family; Region: TIGR00733 426355010821 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 426355010822 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 426355010823 ATP binding site [chemical binding]; other site 426355010824 Mg++ binding site [ion binding]; other site 426355010825 motif III; other site 426355010826 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426355010827 nucleotide binding region [chemical binding]; other site 426355010828 ATP-binding site [chemical binding]; other site 426355010829 YtkA-like; Region: YtkA; pfam13115 426355010830 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 426355010831 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355010832 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 426355010833 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 426355010834 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 426355010835 putative [4Fe-4S] binding site [ion binding]; other site 426355010836 putative molybdopterin cofactor binding site [chemical binding]; other site 426355010837 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 426355010838 putative molybdopterin cofactor binding site; other site 426355010839 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 426355010840 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 426355010841 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 426355010842 E-class dimer interface [polypeptide binding]; other site 426355010843 P-class dimer interface [polypeptide binding]; other site 426355010844 active site 426355010845 Cu2+ binding site [ion binding]; other site 426355010846 Zn2+ binding site [ion binding]; other site 426355010847 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 426355010848 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426355010849 RNA binding surface [nucleotide binding]; other site 426355010850 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 426355010851 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 426355010852 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 426355010853 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 426355010854 Cl binding site [ion binding]; other site 426355010855 oligomer interface [polypeptide binding]; other site 426355010856 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426355010857 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355010858 dimerization interface [polypeptide binding]; other site 426355010859 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355010860 dimer interface [polypeptide binding]; other site 426355010861 putative CheW interface [polypeptide binding]; other site 426355010862 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 426355010863 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 426355010864 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 426355010865 B12 binding site [chemical binding]; other site 426355010866 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 426355010867 FeS/SAM binding site; other site 426355010868 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 426355010869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355010870 NAD(P) binding site [chemical binding]; other site 426355010871 active site 426355010872 enoyl-CoA hydratase; Provisional; Region: PRK06688 426355010873 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426355010874 substrate binding site [chemical binding]; other site 426355010875 oxyanion hole (OAH) forming residues; other site 426355010876 trimer interface [polypeptide binding]; other site 426355010877 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426355010878 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426355010879 active site 426355010880 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 426355010881 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 426355010882 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 426355010883 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 426355010884 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 426355010885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355010886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355010887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426355010888 dimerization interface [polypeptide binding]; other site 426355010889 transcription elongation factor regulatory protein; Validated; Region: PRK06342 426355010890 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 426355010891 Methyltransferase domain; Region: Methyltransf_31; pfam13847 426355010892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355010893 S-adenosylmethionine binding site [chemical binding]; other site 426355010894 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 426355010895 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 426355010896 NADP binding site [chemical binding]; other site 426355010897 dimer interface [polypeptide binding]; other site 426355010898 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 426355010899 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 426355010900 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 426355010901 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 426355010902 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 426355010903 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 426355010904 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 426355010905 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 426355010906 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 426355010907 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 426355010908 DNA binding site [nucleotide binding] 426355010909 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 426355010910 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 426355010911 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 426355010912 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 426355010913 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 426355010914 RPB11 interaction site [polypeptide binding]; other site 426355010915 RPB12 interaction site [polypeptide binding]; other site 426355010916 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 426355010917 RPB3 interaction site [polypeptide binding]; other site 426355010918 RPB1 interaction site [polypeptide binding]; other site 426355010919 RPB11 interaction site [polypeptide binding]; other site 426355010920 RPB10 interaction site [polypeptide binding]; other site 426355010921 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 426355010922 core dimer interface [polypeptide binding]; other site 426355010923 peripheral dimer interface [polypeptide binding]; other site 426355010924 L10 interface [polypeptide binding]; other site 426355010925 L11 interface [polypeptide binding]; other site 426355010926 putative EF-Tu interaction site [polypeptide binding]; other site 426355010927 putative EF-G interaction site [polypeptide binding]; other site 426355010928 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 426355010929 23S rRNA interface [nucleotide binding]; other site 426355010930 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 426355010931 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 426355010932 B12 binding domain; Region: B12-binding; pfam02310 426355010933 B12 binding site [chemical binding]; other site 426355010934 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 426355010935 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 426355010936 mRNA/rRNA interface [nucleotide binding]; other site 426355010937 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 426355010938 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 426355010939 23S rRNA interface [nucleotide binding]; other site 426355010940 L7/L12 interface [polypeptide binding]; other site 426355010941 putative thiostrepton binding site; other site 426355010942 L25 interface [polypeptide binding]; other site 426355010943 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 426355010944 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 426355010945 putative homodimer interface [polypeptide binding]; other site 426355010946 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 426355010947 heterodimer interface [polypeptide binding]; other site 426355010948 homodimer interface [polypeptide binding]; other site 426355010949 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 426355010950 elongation factor Tu; Reviewed; Region: PRK00049 426355010951 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 426355010952 G1 box; other site 426355010953 GEF interaction site [polypeptide binding]; other site 426355010954 GTP/Mg2+ binding site [chemical binding]; other site 426355010955 Switch I region; other site 426355010956 G2 box; other site 426355010957 G3 box; other site 426355010958 Switch II region; other site 426355010959 G4 box; other site 426355010960 G5 box; other site 426355010961 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 426355010962 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 426355010963 Antibiotic Binding Site [chemical binding]; other site 426355010964 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 426355010965 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 426355010966 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 426355010967 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426355010968 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 426355010969 active site 426355010970 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 426355010971 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355010972 Walker A/P-loop; other site 426355010973 ATP binding site [chemical binding]; other site 426355010974 Q-loop/lid; other site 426355010975 ABC transporter signature motif; other site 426355010976 Walker B; other site 426355010977 D-loop; other site 426355010978 H-loop/switch region; other site 426355010979 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 426355010980 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355010981 Walker A/P-loop; other site 426355010982 ATP binding site [chemical binding]; other site 426355010983 Q-loop/lid; other site 426355010984 ABC transporter signature motif; other site 426355010985 Walker B; other site 426355010986 D-loop; other site 426355010987 H-loop/switch region; other site 426355010988 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426355010989 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426355010990 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 426355010991 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 426355010992 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 426355010993 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 426355010994 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 426355010995 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 426355010996 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 426355010997 DNA-binding site [nucleotide binding]; DNA binding site 426355010998 UTRA domain; Region: UTRA; pfam07702 426355010999 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 426355011000 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 426355011001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355011002 dimer interface [polypeptide binding]; other site 426355011003 conserved gate region; other site 426355011004 ABC-ATPase subunit interface; other site 426355011005 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 426355011006 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355011007 membrane-bound complex binding site; other site 426355011008 hinge residues; other site 426355011009 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 426355011010 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 426355011011 Walker A/P-loop; other site 426355011012 ATP binding site [chemical binding]; other site 426355011013 Q-loop/lid; other site 426355011014 ABC transporter signature motif; other site 426355011015 Walker B; other site 426355011016 D-loop; other site 426355011017 H-loop/switch region; other site 426355011018 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 426355011019 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 426355011020 ligand binding site; other site 426355011021 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 426355011022 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 426355011023 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 426355011024 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355011025 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 426355011026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355011027 putative substrate translocation pore; other site 426355011028 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 426355011029 active site 426355011030 catalytic residues [active] 426355011031 metal binding site [ion binding]; metal-binding site 426355011032 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 426355011033 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426355011034 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355011035 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355011036 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 426355011037 putative dimerization interface [polypeptide binding]; other site 426355011038 LemA family; Region: LemA; pfam04011 426355011039 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 426355011040 Repair protein; Region: Repair_PSII; pfam04536 426355011041 Repair protein; Region: Repair_PSII; cl01535 426355011042 Repair protein; Region: Repair_PSII; cl01535 426355011043 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426355011044 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426355011045 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 426355011046 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 426355011047 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426355011048 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 426355011049 Cytochrome P450; Region: p450; cl12078 426355011050 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 426355011051 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 426355011052 NAD binding site [chemical binding]; other site 426355011053 catalytic Zn binding site [ion binding]; other site 426355011054 structural Zn binding site [ion binding]; other site 426355011055 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 426355011056 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 426355011057 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426355011058 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426355011059 catalytic residue [active] 426355011060 NnrU protein; Region: NnrU; pfam07298 426355011061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 426355011062 GTP-binding protein Der; Reviewed; Region: PRK00093 426355011063 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 426355011064 G1 box; other site 426355011065 GTP/Mg2+ binding site [chemical binding]; other site 426355011066 Switch I region; other site 426355011067 G2 box; other site 426355011068 Switch II region; other site 426355011069 G3 box; other site 426355011070 G4 box; other site 426355011071 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 426355011072 G1 box; other site 426355011073 GTP/Mg2+ binding site [chemical binding]; other site 426355011074 Switch I region; other site 426355011075 G2 box; other site 426355011076 G3 box; other site 426355011077 Switch II region; other site 426355011078 G4 box; other site 426355011079 G5 box; other site 426355011080 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 426355011081 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 426355011082 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 426355011083 folate binding site [chemical binding]; other site 426355011084 NADP+ binding site [chemical binding]; other site 426355011085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355011086 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 426355011087 NAD(P) binding site [chemical binding]; other site 426355011088 active site 426355011089 amidophosphoribosyltransferase; Provisional; Region: PRK09123 426355011090 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 426355011091 active site 426355011092 tetramer interface [polypeptide binding]; other site 426355011093 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426355011094 active site 426355011095 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 426355011096 Colicin V production protein; Region: Colicin_V; pfam02674 426355011097 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 426355011098 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 426355011099 active site 426355011100 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426355011101 dimer interface [polypeptide binding]; other site 426355011102 substrate binding site [chemical binding]; other site 426355011103 catalytic residues [active] 426355011104 DNA repair protein RadA; Provisional; Region: PRK11823 426355011105 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 426355011106 Walker A motif/ATP binding site; other site 426355011107 ATP binding site [chemical binding]; other site 426355011108 Walker B motif; other site 426355011109 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 426355011110 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 426355011111 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355011112 FeS/SAM binding site; other site 426355011113 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 426355011114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 426355011115 Cupin domain; Region: Cupin_2; pfam07883 426355011116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426355011117 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426355011118 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 426355011119 Ligand binding site; other site 426355011120 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 426355011121 DXD motif; other site 426355011122 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 426355011123 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 426355011124 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 426355011125 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 426355011126 classical (c) SDRs; Region: SDR_c; cd05233 426355011127 NAD(P) binding site [chemical binding]; other site 426355011128 active site 426355011129 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 426355011130 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 426355011131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 426355011132 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426355011133 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426355011134 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 426355011135 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 426355011136 dimerization interface [polypeptide binding]; other site 426355011137 DPS ferroxidase diiron center [ion binding]; other site 426355011138 ion pore; other site 426355011139 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 426355011140 CoA binding domain; Region: CoA_binding_2; pfam13380 426355011141 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 426355011142 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 426355011143 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 426355011144 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426355011145 Coenzyme A binding pocket [chemical binding]; other site 426355011146 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355011147 Restriction endonuclease; Region: Mrr_cat; pfam04471 426355011148 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 426355011149 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 426355011150 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 426355011151 catalytic triad [active] 426355011152 dimer interface [polypeptide binding]; other site 426355011153 hypothetical protein; Validated; Region: PRK00228 426355011154 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 426355011155 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 426355011156 nucleotide binding site [chemical binding]; other site 426355011157 NEF interaction site [polypeptide binding]; other site 426355011158 SBD interface [polypeptide binding]; other site 426355011159 chaperone protein DnaJ; Provisional; Region: PRK10767 426355011160 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 426355011161 HSP70 interaction site [polypeptide binding]; other site 426355011162 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 426355011163 substrate binding site [polypeptide binding]; other site 426355011164 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 426355011165 Zn binding sites [ion binding]; other site 426355011166 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 426355011167 dimer interface [polypeptide binding]; other site 426355011168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355011169 S-adenosylmethionine binding site [chemical binding]; other site 426355011170 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 426355011171 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 426355011172 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 426355011173 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 426355011174 intersubunit interface [polypeptide binding]; other site 426355011175 active site 426355011176 catalytic residue [active] 426355011177 purine nucleoside phosphorylase; Provisional; Region: PRK08202 426355011178 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 426355011179 active site 426355011180 catalytic motif [active] 426355011181 Zn binding site [ion binding]; other site 426355011182 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 426355011183 RNA polymerase sigma factor; Provisional; Region: PRK12511 426355011184 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355011185 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426355011186 DNA binding residues [nucleotide binding] 426355011187 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 426355011188 catalytic residues [active] 426355011189 dimer interface [polypeptide binding]; other site 426355011190 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 426355011191 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 426355011192 nucleophile elbow; other site 426355011193 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 426355011194 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 426355011195 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 426355011196 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 426355011197 potassium uptake protein; Region: kup; TIGR00794 426355011198 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 426355011199 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355011200 catalytic loop [active] 426355011201 iron binding site [ion binding]; other site 426355011202 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426355011203 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426355011204 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355011205 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426355011206 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355011207 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355011208 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 426355011209 NAD-dependent deacetylase; Provisional; Region: PRK00481 426355011210 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 426355011211 NAD+ binding site [chemical binding]; other site 426355011212 substrate binding site [chemical binding]; other site 426355011213 Zn binding site [ion binding]; other site 426355011214 Isochorismatase family; Region: Isochorismatase; pfam00857 426355011215 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 426355011216 catalytic triad [active] 426355011217 conserved cis-peptide bond; other site 426355011218 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 426355011219 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 426355011220 conserved cys residue [active] 426355011221 dihydropyrimidinase; Provisional; Region: PRK13404 426355011222 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 426355011223 tetramer interface [polypeptide binding]; other site 426355011224 active site 426355011225 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 426355011226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355011227 Walker A/P-loop; other site 426355011228 ATP binding site [chemical binding]; other site 426355011229 Q-loop/lid; other site 426355011230 ABC transporter signature motif; other site 426355011231 Walker B; other site 426355011232 D-loop; other site 426355011233 H-loop/switch region; other site 426355011234 TOBE domain; Region: TOBE_2; pfam08402 426355011235 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 426355011236 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 426355011237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355011238 dimer interface [polypeptide binding]; other site 426355011239 conserved gate region; other site 426355011240 putative PBP binding loops; other site 426355011241 ABC-ATPase subunit interface; other site 426355011242 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 426355011243 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 426355011244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355011245 dimer interface [polypeptide binding]; other site 426355011246 ABC-ATPase subunit interface; other site 426355011247 putative PBP binding loops; other site 426355011248 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 426355011249 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 426355011250 5S rRNA interface [nucleotide binding]; other site 426355011251 CTC domain interface [polypeptide binding]; other site 426355011252 L16 interface [polypeptide binding]; other site 426355011253 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 426355011254 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 426355011255 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 426355011256 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 426355011257 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 426355011258 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 426355011259 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 426355011260 TrkA-N domain; Region: TrkA_N; pfam02254 426355011261 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 426355011262 putative efflux protein, MATE family; Region: matE; TIGR00797 426355011263 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 426355011264 Cupin domain; Region: Cupin_2; pfam07883 426355011265 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 426355011266 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 426355011267 dimer interface [polypeptide binding]; other site 426355011268 active site 426355011269 glycine-pyridoxal phosphate binding site [chemical binding]; other site 426355011270 folate binding site [chemical binding]; other site 426355011271 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 426355011272 ATP cone domain; Region: ATP-cone; pfam03477 426355011273 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 426355011274 catalytic motif [active] 426355011275 Zn binding site [ion binding]; other site 426355011276 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 426355011277 RibD C-terminal domain; Region: RibD_C; cl17279 426355011278 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 426355011279 Lumazine binding domain; Region: Lum_binding; pfam00677 426355011280 Lumazine binding domain; Region: Lum_binding; pfam00677 426355011281 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 426355011282 CoenzymeA binding site [chemical binding]; other site 426355011283 subunit interaction site [polypeptide binding]; other site 426355011284 PHB binding site; other site 426355011285 SpoVR family protein; Provisional; Region: PRK11767 426355011286 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 426355011287 hypothetical protein; Provisional; Region: PRK05325 426355011288 PrkA family serine protein kinase; Provisional; Region: PRK15455 426355011289 AAA ATPase domain; Region: AAA_16; pfam13191 426355011290 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 426355011291 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 426355011292 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 426355011293 DNA binding residues [nucleotide binding] 426355011294 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 426355011295 IHF dimer interface [polypeptide binding]; other site 426355011296 IHF - DNA interface [nucleotide binding]; other site 426355011297 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 426355011298 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 426355011299 dimer interface [polypeptide binding]; other site 426355011300 active site 426355011301 CoA binding pocket [chemical binding]; other site 426355011302 putative phosphate acyltransferase; Provisional; Region: PRK05331 426355011303 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 426355011304 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 426355011305 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 426355011306 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 426355011307 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 426355011308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426355011309 motif II; other site 426355011310 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426355011311 GAF domain; Region: GAF; pfam01590 426355011312 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355011313 PAS fold; Region: PAS_3; pfam08447 426355011314 putative active site [active] 426355011315 heme pocket [chemical binding]; other site 426355011316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355011317 PAS domain; Region: PAS_9; pfam13426 426355011318 putative active site [active] 426355011319 heme pocket [chemical binding]; other site 426355011320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355011321 HWE histidine kinase; Region: HWE_HK; smart00911 426355011322 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 426355011323 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 426355011324 FMN binding site [chemical binding]; other site 426355011325 active site 426355011326 substrate binding site [chemical binding]; other site 426355011327 catalytic residue [active] 426355011328 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 426355011329 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 426355011330 thiamine monophosphate kinase; Provisional; Region: PRK05731 426355011331 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 426355011332 ATP binding site [chemical binding]; other site 426355011333 dimerization interface [polypeptide binding]; other site 426355011334 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 426355011335 putative RNA binding site [nucleotide binding]; other site 426355011336 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 426355011337 homopentamer interface [polypeptide binding]; other site 426355011338 active site 426355011339 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 426355011340 classical (c) SDRs; Region: SDR_c; cd05233 426355011341 NAD(P) binding site [chemical binding]; other site 426355011342 active site 426355011343 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 426355011344 nudix motif; other site 426355011345 Protein of unknown function (DUF2385); Region: DUF2385; pfam09539 426355011346 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 426355011347 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 426355011348 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 426355011349 HD domain; Region: HD_3; cl17350 426355011350 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 426355011351 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 426355011352 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 426355011353 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 426355011354 TPP-binding site; other site 426355011355 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 426355011356 PYR/PP interface [polypeptide binding]; other site 426355011357 dimer interface [polypeptide binding]; other site 426355011358 TPP binding site [chemical binding]; other site 426355011359 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 426355011360 tartrate dehydrogenase; Region: TTC; TIGR02089 426355011361 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 426355011362 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 426355011363 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 426355011364 Cl- selectivity filter; other site 426355011365 Cl- binding residues [ion binding]; other site 426355011366 pore gating glutamate residue; other site 426355011367 dimer interface [polypeptide binding]; other site 426355011368 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 426355011369 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 426355011370 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426355011371 active site 426355011372 Response regulator receiver domain; Region: Response_reg; pfam00072 426355011373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355011374 active site 426355011375 phosphorylation site [posttranslational modification] 426355011376 intermolecular recognition site; other site 426355011377 dimerization interface [polypeptide binding]; other site 426355011378 PilZ domain; Region: PilZ; pfam07238 426355011379 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 426355011380 EamA-like transporter family; Region: EamA; pfam00892 426355011381 EamA-like transporter family; Region: EamA; pfam00892 426355011382 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426355011383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355011384 Anti-sigma-K factor rskA; Region: RskA; pfam10099 426355011385 RNA polymerase sigma factor; Provisional; Region: PRK12514 426355011386 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355011387 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426355011388 DNA binding residues [nucleotide binding] 426355011389 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 426355011390 Uncharacterized conserved protein [Function unknown]; Region: COG2128 426355011391 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 426355011392 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 426355011393 dimer interface [polypeptide binding]; other site 426355011394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355011395 catalytic residue [active] 426355011396 NlpC/P60 family; Region: NLPC_P60; cl17555 426355011397 Autoinducer synthetase; Region: Autoind_synth; cl17404 426355011398 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355011399 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426355011400 putative ligand binding site [chemical binding]; other site 426355011401 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 426355011402 classical (c) SDRs; Region: SDR_c; cd05233 426355011403 NAD(P) binding site [chemical binding]; other site 426355011404 active site 426355011405 RNA polymerase sigma factor; Provisional; Region: PRK12540 426355011406 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355011407 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426355011408 DNA binding residues [nucleotide binding] 426355011409 Isochorismatase family; Region: Isochorismatase; pfam00857 426355011410 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 426355011411 catalytic triad [active] 426355011412 conserved cis-peptide bond; other site 426355011413 Sel1-like repeats; Region: SEL1; smart00671 426355011414 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 426355011415 Sel1-like repeats; Region: SEL1; smart00671 426355011416 Sel1-like repeats; Region: SEL1; smart00671 426355011417 Sel1-like repeats; Region: SEL1; smart00671 426355011418 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 426355011419 active site 426355011420 homotetramer interface [polypeptide binding]; other site 426355011421 homodimer interface [polypeptide binding]; other site 426355011422 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 426355011423 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 426355011424 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 426355011425 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 426355011426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355011427 active site 426355011428 phosphorylation site [posttranslational modification] 426355011429 intermolecular recognition site; other site 426355011430 dimerization interface [polypeptide binding]; other site 426355011431 CheB methylesterase; Region: CheB_methylest; pfam01339 426355011432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355011433 Response regulator receiver domain; Region: Response_reg; pfam00072 426355011434 active site 426355011435 phosphorylation site [posttranslational modification] 426355011436 intermolecular recognition site; other site 426355011437 dimerization interface [polypeptide binding]; other site 426355011438 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 426355011439 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 426355011440 putative binding surface; other site 426355011441 active site 426355011442 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 426355011443 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 426355011444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355011445 ATP binding site [chemical binding]; other site 426355011446 Mg2+ binding site [ion binding]; other site 426355011447 G-X-G motif; other site 426355011448 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 426355011449 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355011450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355011451 active site 426355011452 phosphorylation site [posttranslational modification] 426355011453 intermolecular recognition site; other site 426355011454 dimerization interface [polypeptide binding]; other site 426355011455 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 426355011456 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 426355011457 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 426355011458 metal binding triad; other site 426355011459 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 426355011460 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 426355011461 metal binding triad; other site 426355011462 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 426355011463 active site 426355011464 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 426355011465 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 426355011466 diaminopimelate decarboxylase; Region: lysA; TIGR01048 426355011467 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 426355011468 active site 426355011469 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426355011470 substrate binding site [chemical binding]; other site 426355011471 catalytic residues [active] 426355011472 dimer interface [polypeptide binding]; other site 426355011473 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 426355011474 putative metal binding site; other site 426355011475 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 426355011476 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 426355011477 Citrate transporter; Region: CitMHS; pfam03600 426355011478 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355011479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355011480 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 426355011481 putative dimerization interface [polypeptide binding]; other site 426355011482 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 426355011483 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 426355011484 active site 426355011485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355011486 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 426355011487 Walker A/P-loop; other site 426355011488 ATP binding site [chemical binding]; other site 426355011489 Q-loop/lid; other site 426355011490 ABC transporter signature motif; other site 426355011491 Walker B; other site 426355011492 D-loop; other site 426355011493 H-loop/switch region; other site 426355011494 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426355011495 MarR family; Region: MarR_2; pfam12802 426355011496 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 426355011497 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426355011498 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355011499 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426355011500 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 426355011501 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 426355011502 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 426355011503 GIY-YIG motif/motif A; other site 426355011504 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 426355011505 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426355011506 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 426355011507 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355011508 dimer interface [polypeptide binding]; other site 426355011509 putative CheW interface [polypeptide binding]; other site 426355011510 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426355011511 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355011512 substrate binding pocket [chemical binding]; other site 426355011513 membrane-bound complex binding site; other site 426355011514 hinge residues; other site 426355011515 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 426355011516 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 426355011517 nickel responsive regulator; Provisional; Region: PRK02967 426355011518 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 426355011519 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 426355011520 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 426355011521 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 426355011522 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 426355011523 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 426355011524 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426355011525 N-terminal plug; other site 426355011526 ligand-binding site [chemical binding]; other site 426355011527 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 426355011528 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355011529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355011530 active site 426355011531 phosphorylation site [posttranslational modification] 426355011532 intermolecular recognition site; other site 426355011533 dimerization interface [polypeptide binding]; other site 426355011534 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355011535 DNA binding site [nucleotide binding] 426355011536 MarR family; Region: MarR_2; pfam12802 426355011537 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 426355011538 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 426355011539 active site 426355011540 putative substrate binding pocket [chemical binding]; other site 426355011541 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 426355011542 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 426355011543 Potassium binding sites [ion binding]; other site 426355011544 Cesium cation binding sites [ion binding]; other site 426355011545 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 426355011546 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 426355011547 ligand binding site [chemical binding]; other site 426355011548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426355011549 binding surface 426355011550 TPR motif; other site 426355011551 Tetratricopeptide repeat; Region: TPR_12; pfam13424 426355011552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426355011553 binding surface 426355011554 TPR motif; other site 426355011555 TPR repeat; Region: TPR_11; pfam13414 426355011556 TPR repeat; Region: TPR_11; pfam13414 426355011557 TPR repeat; Region: TPR_11; pfam13414 426355011558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426355011559 binding surface 426355011560 TPR motif; other site 426355011561 TPR repeat; Region: TPR_11; pfam13414 426355011562 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 426355011563 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 426355011564 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 426355011565 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 426355011566 Fe-S cluster binding site [ion binding]; other site 426355011567 active site 426355011568 Predicted metalloprotease [General function prediction only]; Region: COG2321 426355011569 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 426355011570 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 426355011571 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426355011572 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426355011573 ABC transporter; Region: ABC_tran_2; pfam12848 426355011574 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 426355011575 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 426355011576 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 426355011577 trmE is a tRNA modification GTPase; Region: trmE; cd04164 426355011578 G1 box; other site 426355011579 GTP/Mg2+ binding site [chemical binding]; other site 426355011580 Switch I region; other site 426355011581 G2 box; other site 426355011582 Switch II region; other site 426355011583 G3 box; other site 426355011584 G4 box; other site 426355011585 G5 box; other site 426355011586 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 426355011587 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 426355011588 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 426355011589 putative deacylase active site [active] 426355011590 pantoate--beta-alanine ligase; Region: panC; TIGR00018 426355011591 Pantoate-beta-alanine ligase; Region: PanC; cd00560 426355011592 active site 426355011593 ATP-binding site [chemical binding]; other site 426355011594 pantoate-binding site; other site 426355011595 HXXH motif; other site 426355011596 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 426355011597 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 426355011598 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355011599 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 426355011600 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 426355011601 metal-binding site [ion binding] 426355011602 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 426355011603 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 426355011604 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 426355011605 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 426355011606 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 426355011607 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 426355011608 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426355011609 P-loop; other site 426355011610 Magnesium ion binding site [ion binding]; other site 426355011611 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426355011612 Magnesium ion binding site [ion binding]; other site 426355011613 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 426355011614 ParB-like nuclease domain; Region: ParB; smart00470 426355011615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355011616 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 426355011617 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 426355011618 Lipopolysaccharide-assembly; Region: LptE; cl01125 426355011619 Predicted permeases [General function prediction only]; Region: COG0679 426355011620 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 426355011621 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426355011622 N-terminal plug; other site 426355011623 ligand-binding site [chemical binding]; other site 426355011624 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 426355011625 active site 426355011626 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 426355011627 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 426355011628 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 426355011629 trimer interface [polypeptide binding]; other site 426355011630 active site 426355011631 substrate binding site [chemical binding]; other site 426355011632 CoA binding site [chemical binding]; other site 426355011633 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355011634 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355011635 ligand binding site [chemical binding]; other site 426355011636 flexible hinge region; other site 426355011637 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355011638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355011639 active site 426355011640 phosphorylation site [posttranslational modification] 426355011641 intermolecular recognition site; other site 426355011642 dimerization interface [polypeptide binding]; other site 426355011643 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355011644 DNA binding site [nucleotide binding] 426355011645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 426355011646 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 426355011647 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426355011648 catalytic residue [active] 426355011649 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 426355011650 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 426355011651 HIGH motif; other site 426355011652 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 426355011653 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 426355011654 active site 426355011655 KMSKS motif; other site 426355011656 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 426355011657 tRNA binding surface [nucleotide binding]; other site 426355011658 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 426355011659 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 426355011660 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355011661 substrate binding pocket [chemical binding]; other site 426355011662 membrane-bound complex binding site; other site 426355011663 hinge residues; other site 426355011664 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 426355011665 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 426355011666 putative lipid kinase; Reviewed; Region: PRK13057 426355011667 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 426355011668 active site 426355011669 catalytic residues [active] 426355011670 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 426355011671 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 426355011672 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 426355011673 putative dimer interface [polypeptide binding]; other site 426355011674 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 426355011675 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 426355011676 putative dimer interface [polypeptide binding]; other site 426355011677 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 426355011678 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 426355011679 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 426355011680 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 426355011681 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 426355011682 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 426355011683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355011684 S-adenosylmethionine binding site [chemical binding]; other site 426355011685 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 426355011686 putative active site [active] 426355011687 putative catalytic site [active] 426355011688 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 426355011689 putative active site [active] 426355011690 putative catalytic site [active] 426355011691 GTP-binding protein YchF; Reviewed; Region: PRK09601 426355011692 YchF GTPase; Region: YchF; cd01900 426355011693 G1 box; other site 426355011694 GTP/Mg2+ binding site [chemical binding]; other site 426355011695 Switch I region; other site 426355011696 G2 box; other site 426355011697 Switch II region; other site 426355011698 G3 box; other site 426355011699 G4 box; other site 426355011700 G5 box; other site 426355011701 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 426355011702 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 426355011703 putative active site [active] 426355011704 catalytic residue [active] 426355011705 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 426355011706 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355011707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355011708 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 426355011709 putative dimerization interface [polypeptide binding]; other site 426355011710 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 426355011711 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 426355011712 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 426355011713 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426355011714 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 426355011715 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426355011716 active site 426355011717 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 426355011718 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 426355011719 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426355011720 active site 426355011721 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 426355011722 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426355011723 active site 426355011724 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 426355011725 Strictosidine synthase; Region: Str_synth; pfam03088 426355011726 benzoate transport; Region: 2A0115; TIGR00895 426355011727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355011728 putative substrate translocation pore; other site 426355011729 hypothetical protein; Validated; Region: PRK06201 426355011730 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 426355011731 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 426355011732 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 426355011733 NAD binding site [chemical binding]; other site 426355011734 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 426355011735 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 426355011736 FAD binding domain; Region: FAD_binding_4; pfam01565 426355011737 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 426355011738 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 426355011739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355011740 putative substrate translocation pore; other site 426355011741 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 426355011742 Transcriptional regulator [Transcription]; Region: IclR; COG1414 426355011743 Bacterial transcriptional regulator; Region: IclR; pfam01614 426355011744 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 426355011745 synthetase active site [active] 426355011746 NTP binding site [chemical binding]; other site 426355011747 metal binding site [ion binding]; metal-binding site 426355011748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355011749 sequence-specific DNA binding site [nucleotide binding]; other site 426355011750 salt bridge; other site 426355011751 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 426355011752 AAA domain; Region: AAA_25; pfam13481 426355011753 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426355011754 Walker A motif; other site 426355011755 ATP binding site [chemical binding]; other site 426355011756 Walker B motif; other site 426355011757 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426355011758 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 426355011759 catalytic residues [active] 426355011760 catalytic nucleophile [active] 426355011761 Recombinase; Region: Recombinase; pfam07508 426355011762 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 426355011763 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 426355011764 catalytic residue [active] 426355011765 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 426355011766 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 426355011767 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 426355011768 active site 426355011769 catalytic residues [active] 426355011770 DNA binding site [nucleotide binding] 426355011771 Int/Topo IB signature motif; other site 426355011772 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 426355011773 tellurite resistance protein terB; Region: terB; cd07176 426355011774 putative metal binding site [ion binding]; other site 426355011775 PAS domain; Region: PAS_9; pfam13426 426355011776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355011777 putative active site [active] 426355011778 heme pocket [chemical binding]; other site 426355011779 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939 426355011780 Patatin phospholipase; Region: DUF3734; pfam12536 426355011781 Predicted transcriptional regulator [Transcription]; Region: COG2378 426355011782 HTH domain; Region: HTH_11; pfam08279 426355011783 WYL domain; Region: WYL; pfam13280 426355011784 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426355011785 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 426355011786 putative C-terminal domain interface [polypeptide binding]; other site 426355011787 putative GSH binding site (G-site) [chemical binding]; other site 426355011788 putative dimer interface [polypeptide binding]; other site 426355011789 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 426355011790 N-terminal domain interface [polypeptide binding]; other site 426355011791 dimer interface [polypeptide binding]; other site 426355011792 substrate binding pocket (H-site) [chemical binding]; other site 426355011793 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 426355011794 PAS fold; Region: PAS_7; pfam12860 426355011795 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355011796 putative active site [active] 426355011797 PAS fold; Region: PAS_3; pfam08447 426355011798 heme pocket [chemical binding]; other site 426355011799 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355011800 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355011801 metal binding site [ion binding]; metal-binding site 426355011802 active site 426355011803 I-site; other site 426355011804 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355011805 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 426355011806 dimer interface [polypeptide binding]; other site 426355011807 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426355011808 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426355011809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355011810 active site 426355011811 phosphorylation site [posttranslational modification] 426355011812 intermolecular recognition site; other site 426355011813 dimerization interface [polypeptide binding]; other site 426355011814 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355011815 DNA binding residues [nucleotide binding] 426355011816 dimerization interface [polypeptide binding]; other site 426355011817 Uncharacterized conserved protein [Function unknown]; Region: COG3391 426355011818 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426355011819 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426355011820 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426355011821 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426355011822 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 426355011823 putative hydrophobic ligand binding site [chemical binding]; other site 426355011824 protein interface [polypeptide binding]; other site 426355011825 gate; other site 426355011826 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 426355011827 metal ion-dependent adhesion site (MIDAS); other site 426355011828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 426355011829 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 426355011830 metal ion-dependent adhesion site (MIDAS); other site 426355011831 Protein of unknown function DUF58; Region: DUF58; pfam01882 426355011832 MoxR-like ATPases [General function prediction only]; Region: COG0714 426355011833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355011834 Walker A motif; other site 426355011835 ATP binding site [chemical binding]; other site 426355011836 Walker B motif; other site 426355011837 arginine finger; other site 426355011838 Methanol dehydrogenase beta subunit; Region: MDH; pfam02315 426355011839 cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872 426355011840 methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870 426355011841 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355011842 substrate binding pocket [chemical binding]; other site 426355011843 membrane-bound complex binding site; other site 426355011844 hinge residues; other site 426355011845 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 426355011846 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 426355011847 Trp docking motif [polypeptide binding]; other site 426355011848 dimer interface [polypeptide binding]; other site 426355011849 active site 426355011850 small subunit binding site [polypeptide binding]; other site 426355011851 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426355011852 Cytochrome P450; Region: p450; cl12078 426355011853 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 426355011854 PAS domain; Region: PAS_9; pfam13426 426355011855 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 426355011856 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355011857 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355011858 metal binding site [ion binding]; metal-binding site 426355011859 active site 426355011860 I-site; other site 426355011861 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355011862 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 426355011863 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 426355011864 ligand binding site [chemical binding]; other site 426355011865 NAD binding site [chemical binding]; other site 426355011866 dimerization interface [polypeptide binding]; other site 426355011867 catalytic site [active] 426355011868 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 426355011869 sulfite oxidase; Provisional; Region: PLN00177 426355011870 Moco binding site; other site 426355011871 metal coordination site [ion binding]; other site 426355011872 Cytochrome c; Region: Cytochrom_C; cl11414 426355011873 CHASE3 domain; Region: CHASE3; pfam05227 426355011874 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426355011875 cyclase homology domain; Region: CHD; cd07302 426355011876 nucleotidyl binding site; other site 426355011877 metal binding site [ion binding]; metal-binding site 426355011878 dimer interface [polypeptide binding]; other site 426355011879 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 426355011880 Protein of unknown function, DUF606; Region: DUF606; pfam04657 426355011881 Protein of unknown function, DUF606; Region: DUF606; pfam04657 426355011882 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 426355011883 transmembrane helices; other site 426355011884 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 426355011885 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 426355011886 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 426355011887 active site 426355011888 metal binding site [ion binding]; metal-binding site 426355011889 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 426355011890 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 426355011891 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 426355011892 Walker A/P-loop; other site 426355011893 ATP binding site [chemical binding]; other site 426355011894 Q-loop/lid; other site 426355011895 ABC transporter signature motif; other site 426355011896 Walker B; other site 426355011897 D-loop; other site 426355011898 H-loop/switch region; other site 426355011899 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 426355011900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355011901 dimer interface [polypeptide binding]; other site 426355011902 conserved gate region; other site 426355011903 ABC-ATPase subunit interface; other site 426355011904 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 426355011905 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426355011906 active site 426355011907 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 426355011908 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426355011909 active site 426355011910 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 426355011911 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 426355011912 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426355011913 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355011914 substrate binding pocket [chemical binding]; other site 426355011915 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355011916 membrane-bound complex binding site; other site 426355011917 hinge residues; other site 426355011918 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 426355011919 DNA-binding interface [nucleotide binding]; DNA binding site 426355011920 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426355011921 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355011922 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 426355011923 catalytic triad [active] 426355011924 putative active site [active] 426355011925 Autotransporter beta-domain; Region: Autotransporter; pfam03797 426355011926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355011927 active site 426355011928 phosphorylation site [posttranslational modification] 426355011929 intermolecular recognition site; other site 426355011930 dimerization interface [polypeptide binding]; other site 426355011931 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 426355011932 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355011933 putative active site [active] 426355011934 heme pocket [chemical binding]; other site 426355011935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355011936 HWE histidine kinase; Region: HWE_HK; smart00911 426355011937 Domain of unknown function (DUF892); Region: DUF892; pfam05974 426355011938 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 426355011939 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355011940 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 426355011941 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 426355011942 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426355011943 putative metal binding site [ion binding]; other site 426355011944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355011945 D-galactonate transporter; Region: 2A0114; TIGR00893 426355011946 putative substrate translocation pore; other site 426355011947 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 426355011948 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 426355011949 PAS domain; Region: PAS_9; pfam13426 426355011950 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 426355011951 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 426355011952 putative active site [active] 426355011953 putative metal binding residues [ion binding]; other site 426355011954 signature motif; other site 426355011955 putative dimer interface [polypeptide binding]; other site 426355011956 putative phosphate binding site [ion binding]; other site 426355011957 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 426355011958 nudix motif; other site 426355011959 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 426355011960 PAS domain; Region: PAS; smart00091 426355011961 PAS fold; Region: PAS_7; pfam12860 426355011962 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355011963 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355011964 metal binding site [ion binding]; metal-binding site 426355011965 active site 426355011966 I-site; other site 426355011967 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355011968 cytidine deaminase; Provisional; Region: PRK09027 426355011969 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 426355011970 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355011971 catalytic loop [active] 426355011972 iron binding site [ion binding]; other site 426355011973 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426355011974 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 426355011975 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 426355011976 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426355011977 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426355011978 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355011979 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 426355011980 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 426355011981 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 426355011982 SOUL heme-binding protein; Region: SOUL; pfam04832 426355011983 PAS fold; Region: PAS_4; pfam08448 426355011984 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355011985 PAS fold; Region: PAS_3; pfam08447 426355011986 putative active site [active] 426355011987 heme pocket [chemical binding]; other site 426355011988 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355011989 PAS fold; Region: PAS_3; pfam08447 426355011990 putative active site [active] 426355011991 heme pocket [chemical binding]; other site 426355011992 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355011993 putative active site [active] 426355011994 PAS fold; Region: PAS_3; pfam08447 426355011995 heme pocket [chemical binding]; other site 426355011996 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355011997 PAS domain; Region: PAS_9; pfam13426 426355011998 putative active site [active] 426355011999 heme pocket [chemical binding]; other site 426355012000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355012001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355012002 dimer interface [polypeptide binding]; other site 426355012003 phosphorylation site [posttranslational modification] 426355012004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355012005 ATP binding site [chemical binding]; other site 426355012006 Mg2+ binding site [ion binding]; other site 426355012007 G-X-G motif; other site 426355012008 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355012009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355012010 active site 426355012011 phosphorylation site [posttranslational modification] 426355012012 intermolecular recognition site; other site 426355012013 dimerization interface [polypeptide binding]; other site 426355012014 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355012015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355012016 active site 426355012017 phosphorylation site [posttranslational modification] 426355012018 intermolecular recognition site; other site 426355012019 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 426355012020 dimer interface [polypeptide binding]; other site 426355012021 phosphorylation site [posttranslational modification] 426355012022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355012023 ATP binding site [chemical binding]; other site 426355012024 Mg2+ binding site [ion binding]; other site 426355012025 G-X-G motif; other site 426355012026 Response regulator receiver domain; Region: Response_reg; pfam00072 426355012027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355012028 active site 426355012029 phosphorylation site [posttranslational modification] 426355012030 intermolecular recognition site; other site 426355012031 dimerization interface [polypeptide binding]; other site 426355012032 Response regulator receiver domain; Region: Response_reg; pfam00072 426355012033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355012034 active site 426355012035 phosphorylation site [posttranslational modification] 426355012036 intermolecular recognition site; other site 426355012037 dimerization interface [polypeptide binding]; other site 426355012038 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 426355012039 GAF domain; Region: GAF; pfam01590 426355012040 Phytochrome region; Region: PHY; pfam00360 426355012041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355012042 dimer interface [polypeptide binding]; other site 426355012043 phosphorylation site [posttranslational modification] 426355012044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355012045 ATP binding site [chemical binding]; other site 426355012046 Mg2+ binding site [ion binding]; other site 426355012047 G-X-G motif; other site 426355012048 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 426355012049 PA26 p53-induced protein (sestrin); Region: PA26; pfam04636 426355012050 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 426355012051 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 426355012052 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 426355012053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 426355012054 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 426355012055 Protein of unknown function (DUF1190); Region: DUF1190; pfam06693 426355012056 Predicted membrane protein [Function unknown]; Region: COG3766 426355012057 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 426355012058 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 426355012059 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 426355012060 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 426355012061 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 426355012062 active site 426355012063 catalytic site [active] 426355012064 substrate binding site [chemical binding]; other site 426355012065 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 426355012066 dephospho-CoA kinase; Region: TIGR00152 426355012067 CoA-binding site [chemical binding]; other site 426355012068 ATP-binding [chemical binding]; other site 426355012069 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 426355012070 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 426355012071 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 426355012072 NAD(P) binding site [chemical binding]; other site 426355012073 shikimate binding site; other site 426355012074 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 426355012075 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 426355012076 putative active site [active] 426355012077 transcription termination factor Rho; Provisional; Region: rho; PRK09376 426355012078 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 426355012079 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 426355012080 RNA binding site [nucleotide binding]; other site 426355012081 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 426355012082 multimer interface [polypeptide binding]; other site 426355012083 Walker A motif; other site 426355012084 ATP binding site [chemical binding]; other site 426355012085 Walker B motif; other site 426355012086 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 426355012087 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 426355012088 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 426355012089 dimer interface [polypeptide binding]; other site 426355012090 motif 1; other site 426355012091 motif 2; other site 426355012092 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 426355012093 active site 426355012094 motif 3; other site 426355012095 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 426355012096 anticodon binding site; other site 426355012097 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 426355012098 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 426355012099 motif 1; other site 426355012100 dimer interface [polypeptide binding]; other site 426355012101 active site 426355012102 motif 2; other site 426355012103 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 426355012104 active site 426355012105 motif 3; other site 426355012106 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 426355012107 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 426355012108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355012109 LysR substrate binding domain; Region: LysR_substrate; pfam03466 426355012110 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 426355012111 aspartate racemase; Region: asp_race; TIGR00035 426355012112 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 426355012113 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 426355012114 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 426355012115 substrate binding site [chemical binding]; other site 426355012116 active site 426355012117 PEP synthetase regulatory protein; Provisional; Region: PRK05339 426355012118 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 426355012119 EF-hand domain pair; Region: EF_hand_5; pfam13499 426355012120 Ca2+ binding site [ion binding]; other site 426355012121 Oxygen tolerance; Region: BatD; pfam13584 426355012122 von Willebrand factor type A domain; Region: VWA_2; pfam13519 426355012123 metal ion-dependent adhesion site (MIDAS); other site 426355012124 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 426355012125 metal ion-dependent adhesion site (MIDAS); other site 426355012126 Protein of unknown function DUF58; Region: DUF58; pfam01882 426355012127 MoxR-like ATPases [General function prediction only]; Region: COG0714 426355012128 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 426355012129 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 426355012130 MgtC family; Region: MgtC; pfam02308 426355012131 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 426355012132 NlpC/P60 family; Region: NLPC_P60; cl17555 426355012133 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 426355012134 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 426355012135 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 426355012136 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 426355012137 putative active site [active] 426355012138 putative substrate binding site [chemical binding]; other site 426355012139 ATP binding site [chemical binding]; other site 426355012140 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 426355012141 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 426355012142 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 426355012143 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 426355012144 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 426355012145 Protein export membrane protein; Region: SecD_SecF; cl14618 426355012146 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 426355012147 Protein export membrane protein; Region: SecD_SecF; cl14618 426355012148 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426355012149 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426355012150 E3 interaction surface; other site 426355012151 lipoyl attachment site [posttranslational modification]; other site 426355012152 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355012153 hypothetical protein; Provisional; Region: PRK08912 426355012154 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426355012155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355012156 homodimer interface [polypeptide binding]; other site 426355012157 catalytic residue [active] 426355012158 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 426355012159 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 426355012160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355012161 dimer interface [polypeptide binding]; other site 426355012162 conserved gate region; other site 426355012163 ABC-ATPase subunit interface; other site 426355012164 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355012165 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 426355012166 FAD binding domain; Region: FAD_binding_4; pfam01565 426355012167 KpsF/GutQ family protein; Region: kpsF; TIGR00393 426355012168 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 426355012169 putative active site [active] 426355012170 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 426355012171 Short C-terminal domain; Region: SHOCT; pfam09851 426355012172 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 426355012173 putative FMN binding site [chemical binding]; other site 426355012174 GSCFA family; Region: GSCFA; pfam08885 426355012175 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355012176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355012177 active site 426355012178 phosphorylation site [posttranslational modification] 426355012179 intermolecular recognition site; other site 426355012180 dimerization interface [polypeptide binding]; other site 426355012181 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 426355012182 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 426355012183 ligand binding site [chemical binding]; other site 426355012184 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 426355012185 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 426355012186 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 426355012187 Ligand Binding Site [chemical binding]; other site 426355012188 FtsH Extracellular; Region: FtsH_ext; pfam06480 426355012189 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 426355012190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355012191 Walker A motif; other site 426355012192 ATP binding site [chemical binding]; other site 426355012193 Walker B motif; other site 426355012194 arginine finger; other site 426355012195 Peptidase family M41; Region: Peptidase_M41; pfam01434 426355012196 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 426355012197 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 426355012198 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 426355012199 active site 426355012200 substrate binding site [chemical binding]; other site 426355012201 metal binding site [ion binding]; metal-binding site 426355012202 Protein of unknown function (DUF419); Region: DUF419; pfam04237 426355012203 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 426355012204 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 426355012205 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 426355012206 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 426355012207 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 426355012208 active site 426355012209 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 426355012210 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 426355012211 Mechanosensitive ion channel; Region: MS_channel; pfam00924 426355012212 PAS domain; Region: PAS_9; pfam13426 426355012213 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355012214 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355012215 metal binding site [ion binding]; metal-binding site 426355012216 active site 426355012217 I-site; other site 426355012218 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 426355012219 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 426355012220 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426355012221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355012222 Walker A/P-loop; other site 426355012223 ATP binding site [chemical binding]; other site 426355012224 Q-loop/lid; other site 426355012225 ABC transporter signature motif; other site 426355012226 Walker B; other site 426355012227 D-loop; other site 426355012228 H-loop/switch region; other site 426355012229 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 426355012230 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 426355012231 iron-sulfur cluster [ion binding]; other site 426355012232 [2Fe-2S] cluster binding site [ion binding]; other site 426355012233 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 426355012234 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426355012235 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426355012236 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426355012237 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426355012238 active site 426355012239 PAS domain S-box; Region: sensory_box; TIGR00229 426355012240 PAS domain; Region: PAS; smart00091 426355012241 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355012242 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355012243 metal binding site [ion binding]; metal-binding site 426355012244 active site 426355012245 I-site; other site 426355012246 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355012247 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 426355012248 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355012249 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426355012250 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426355012251 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355012252 Phasin protein; Region: Phasin_2; cl11491 426355012253 Phasin protein; Region: Phasin_2; cl11491 426355012254 AMIN domain; Region: AMIN; pfam11741 426355012255 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 426355012256 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 426355012257 active site 426355012258 metal binding site [ion binding]; metal-binding site 426355012259 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 426355012260 Transglycosylase; Region: Transgly; pfam00912 426355012261 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 426355012262 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 426355012263 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 426355012264 putative active site [active] 426355012265 catalytic triad [active] 426355012266 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 426355012267 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 426355012268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355012269 active site 426355012270 phosphorylation site [posttranslational modification] 426355012271 intermolecular recognition site; other site 426355012272 dimerization interface [polypeptide binding]; other site 426355012273 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 426355012274 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355012275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355012276 dimer interface [polypeptide binding]; other site 426355012277 phosphorylation site [posttranslational modification] 426355012278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355012279 ATP binding site [chemical binding]; other site 426355012280 Mg2+ binding site [ion binding]; other site 426355012281 G-X-G motif; other site 426355012282 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 426355012283 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 426355012284 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 426355012285 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 426355012286 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426355012287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355012288 dimer interface [polypeptide binding]; other site 426355012289 conserved gate region; other site 426355012290 ABC-ATPase subunit interface; other site 426355012291 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 426355012292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355012293 dimer interface [polypeptide binding]; other site 426355012294 conserved gate region; other site 426355012295 putative PBP binding loops; other site 426355012296 ABC-ATPase subunit interface; other site 426355012297 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 426355012298 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355012299 Walker A/P-loop; other site 426355012300 ATP binding site [chemical binding]; other site 426355012301 Q-loop/lid; other site 426355012302 ABC transporter signature motif; other site 426355012303 Walker B; other site 426355012304 D-loop; other site 426355012305 H-loop/switch region; other site 426355012306 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426355012307 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 426355012308 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355012309 Walker A/P-loop; other site 426355012310 ATP binding site [chemical binding]; other site 426355012311 Q-loop/lid; other site 426355012312 ABC transporter signature motif; other site 426355012313 Walker B; other site 426355012314 D-loop; other site 426355012315 H-loop/switch region; other site 426355012316 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 426355012317 dihydroorotase; Provisional; Region: PRK09237 426355012318 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426355012319 active site 426355012320 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426355012321 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426355012322 Walker A/P-loop; other site 426355012323 ATP binding site [chemical binding]; other site 426355012324 Q-loop/lid; other site 426355012325 ABC transporter signature motif; other site 426355012326 Walker B; other site 426355012327 D-loop; other site 426355012328 H-loop/switch region; other site 426355012329 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426355012330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355012331 putative PBP binding loops; other site 426355012332 ABC-ATPase subunit interface; other site 426355012333 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 426355012334 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355012335 Domain of unknown function (DUF4202); Region: DUF4202; pfam13875 426355012336 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 426355012337 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355012338 Walker A/P-loop; other site 426355012339 ATP binding site [chemical binding]; other site 426355012340 Q-loop/lid; other site 426355012341 ABC transporter signature motif; other site 426355012342 Walker B; other site 426355012343 D-loop; other site 426355012344 H-loop/switch region; other site 426355012345 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426355012346 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355012347 Walker A/P-loop; other site 426355012348 ATP binding site [chemical binding]; other site 426355012349 Q-loop/lid; other site 426355012350 ABC transporter signature motif; other site 426355012351 Walker B; other site 426355012352 D-loop; other site 426355012353 H-loop/switch region; other site 426355012354 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426355012355 hypothetical protein; Provisional; Region: PRK07079 426355012356 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 426355012357 metal binding site [ion binding]; metal-binding site 426355012358 putative dimer interface [polypeptide binding]; other site 426355012359 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 426355012360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355012361 ABC-ATPase subunit interface; other site 426355012362 putative PBP binding loops; other site 426355012363 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426355012364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355012365 dimer interface [polypeptide binding]; other site 426355012366 conserved gate region; other site 426355012367 putative PBP binding loops; other site 426355012368 ABC-ATPase subunit interface; other site 426355012369 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426355012370 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 426355012371 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355012372 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355012373 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426355012374 dimerization interface [polypeptide binding]; other site 426355012375 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426355012376 AAA domain; Region: AAA_17; pfam13207 426355012377 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 426355012378 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 426355012379 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426355012380 GAF domain; Region: GAF; pfam01590 426355012381 PAS domain S-box; Region: sensory_box; TIGR00229 426355012382 PAS fold; Region: PAS_4; pfam08448 426355012383 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355012384 putative active site [active] 426355012385 heme pocket [chemical binding]; other site 426355012386 PAS domain; Region: PAS_9; pfam13426 426355012387 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355012388 putative active site [active] 426355012389 heme pocket [chemical binding]; other site 426355012390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355012391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355012392 dimer interface [polypeptide binding]; other site 426355012393 phosphorylation site [posttranslational modification] 426355012394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355012395 ATP binding site [chemical binding]; other site 426355012396 Mg2+ binding site [ion binding]; other site 426355012397 G-X-G motif; other site 426355012398 Response regulator receiver domain; Region: Response_reg; pfam00072 426355012399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355012400 active site 426355012401 phosphorylation site [posttranslational modification] 426355012402 intermolecular recognition site; other site 426355012403 dimerization interface [polypeptide binding]; other site 426355012404 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 426355012405 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 426355012406 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426355012407 ATP binding site [chemical binding]; other site 426355012408 putative Mg++ binding site [ion binding]; other site 426355012409 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426355012410 nucleotide binding region [chemical binding]; other site 426355012411 ATP-binding site [chemical binding]; other site 426355012412 TRCF domain; Region: TRCF; pfam03461 426355012413 Domain of unknown function (DUF336); Region: DUF336; pfam03928 426355012414 PAS fold; Region: PAS_3; pfam08447 426355012415 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 426355012416 putative active site [active] 426355012417 heme pocket [chemical binding]; other site 426355012418 allantoate amidohydrolase; Reviewed; Region: PRK12893 426355012419 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 426355012420 active site 426355012421 metal binding site [ion binding]; metal-binding site 426355012422 dimer interface [polypeptide binding]; other site 426355012423 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 426355012424 putative hydrophobic ligand binding site [chemical binding]; other site 426355012425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426355012426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355012427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355012428 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 426355012429 putative effector binding pocket; other site 426355012430 dimerization interface [polypeptide binding]; other site 426355012431 Uncharacterized conserved protein [Function unknown]; Region: COG2353 426355012432 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 426355012433 Uncharacterized conserved protein [Function unknown]; Region: COG2353 426355012434 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 426355012435 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426355012436 Coenzyme A binding pocket [chemical binding]; other site 426355012437 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 426355012438 ornithine decarboxylase; Provisional; Region: PRK13578 426355012439 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426355012440 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426355012441 catalytic residue [active] 426355012442 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 426355012443 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 426355012444 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 426355012445 ligand binding site [chemical binding]; other site 426355012446 NAD binding site [chemical binding]; other site 426355012447 dimerization interface [polypeptide binding]; other site 426355012448 catalytic site [active] 426355012449 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 426355012450 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426355012451 N-terminal plug; other site 426355012452 ligand-binding site [chemical binding]; other site 426355012453 O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080 426355012454 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 426355012455 homodimer interface [polypeptide binding]; other site 426355012456 substrate-cofactor binding pocket; other site 426355012457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355012458 catalytic residue [active] 426355012459 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 426355012460 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 426355012461 putative heme binding pocket [chemical binding]; other site 426355012462 Sensors of blue-light using FAD; Region: BLUF; pfam04940 426355012463 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355012464 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355012465 metal binding site [ion binding]; metal-binding site 426355012466 active site 426355012467 I-site; other site 426355012468 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355012469 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 426355012470 DEAD/DEAH box helicase; Region: DEAD; pfam00270 426355012471 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 426355012472 ATP binding site [chemical binding]; other site 426355012473 putative Mg++ binding site [ion binding]; other site 426355012474 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426355012475 nucleotide binding region [chemical binding]; other site 426355012476 ATP-binding site [chemical binding]; other site 426355012477 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 426355012478 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 426355012479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355012480 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 426355012481 dimerization interface [polypeptide binding]; other site 426355012482 substrate binding pocket [chemical binding]; other site 426355012483 Major Facilitator Superfamily; Region: MFS_1; pfam07690 426355012484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355012485 putative substrate translocation pore; other site 426355012486 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 426355012487 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355012488 catalytic loop [active] 426355012489 iron binding site [ion binding]; other site 426355012490 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 426355012491 cyclase homology domain; Region: CHD; cd07302 426355012492 nucleotidyl binding site; other site 426355012493 metal binding site [ion binding]; metal-binding site 426355012494 dimer interface [polypeptide binding]; other site 426355012495 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 426355012496 active site 426355012497 DNA binding site [nucleotide binding] 426355012498 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355012499 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 426355012500 ligand binding site [chemical binding]; other site 426355012501 regulator interaction site; other site 426355012502 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 426355012503 ANTAR domain; Region: ANTAR; pfam03861 426355012504 Predicted amidohydrolase [General function prediction only]; Region: COG0388 426355012505 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 426355012506 putative active site [active] 426355012507 catalytic triad [active] 426355012508 putative dimer interface [polypeptide binding]; other site 426355012509 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355012510 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 426355012511 putative ligand binding site [chemical binding]; other site 426355012512 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426355012513 TM-ABC transporter signature motif; other site 426355012514 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426355012515 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426355012516 TM-ABC transporter signature motif; other site 426355012517 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 426355012518 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426355012519 Walker A/P-loop; other site 426355012520 ATP binding site [chemical binding]; other site 426355012521 Q-loop/lid; other site 426355012522 ABC transporter signature motif; other site 426355012523 Walker B; other site 426355012524 D-loop; other site 426355012525 H-loop/switch region; other site 426355012526 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426355012527 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426355012528 Walker A/P-loop; other site 426355012529 ATP binding site [chemical binding]; other site 426355012530 Q-loop/lid; other site 426355012531 ABC transporter signature motif; other site 426355012532 Walker B; other site 426355012533 D-loop; other site 426355012534 H-loop/switch region; other site 426355012535 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 426355012536 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 426355012537 Amidase; Region: Amidase; cl11426 426355012538 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 426355012539 CheB methylesterase; Region: CheB_methylest; pfam01339 426355012540 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 426355012541 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 426355012542 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 426355012543 PAS domain; Region: PAS_10; pfam13596 426355012544 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355012545 putative active site [active] 426355012546 heme pocket [chemical binding]; other site 426355012547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355012548 HWE histidine kinase; Region: HWE_HK; smart00911 426355012549 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 426355012550 putative active site [active] 426355012551 heme pocket [chemical binding]; other site 426355012552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355012553 PAS fold; Region: PAS_3; pfam08447 426355012554 putative active site [active] 426355012555 heme pocket [chemical binding]; other site 426355012556 PAS domain S-box; Region: sensory_box; TIGR00229 426355012557 PAS fold; Region: PAS_3; pfam08447 426355012558 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355012559 dimer interface [polypeptide binding]; other site 426355012560 phosphorylation site [posttranslational modification] 426355012561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355012562 ATP binding site [chemical binding]; other site 426355012563 Mg2+ binding site [ion binding]; other site 426355012564 G-X-G motif; other site 426355012565 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355012566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355012567 active site 426355012568 phosphorylation site [posttranslational modification] 426355012569 intermolecular recognition site; other site 426355012570 dimerization interface [polypeptide binding]; other site 426355012571 Major royal jelly protein; Region: MRJP; pfam03022 426355012572 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 426355012573 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 426355012574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355012575 Walker A motif; other site 426355012576 ATP binding site [chemical binding]; other site 426355012577 Walker B motif; other site 426355012578 arginine finger; other site 426355012579 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 426355012580 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 426355012581 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 426355012582 C-terminal domain interface [polypeptide binding]; other site 426355012583 GSH binding site (G-site) [chemical binding]; other site 426355012584 dimer interface [polypeptide binding]; other site 426355012585 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 426355012586 N-terminal domain interface [polypeptide binding]; other site 426355012587 dimer interface [polypeptide binding]; other site 426355012588 substrate binding pocket (H-site) [chemical binding]; other site 426355012589 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 426355012590 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 426355012591 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 426355012592 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355012593 metal binding site [ion binding]; metal-binding site 426355012594 active site 426355012595 I-site; other site 426355012596 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355012597 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 426355012598 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 426355012599 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 426355012600 conserved cys residue [active] 426355012601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355012602 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 426355012603 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355012604 catalytic loop [active] 426355012605 iron binding site [ion binding]; other site 426355012606 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426355012607 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426355012608 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355012609 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426355012610 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355012611 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355012612 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 426355012613 classical (c) SDRs; Region: SDR_c; cd05233 426355012614 NAD(P) binding site [chemical binding]; other site 426355012615 active site 426355012616 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 426355012617 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426355012618 motif II; other site 426355012619 Predicted membrane protein [Function unknown]; Region: COG3059 426355012620 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 426355012621 Cupin; Region: Cupin_6; pfam12852 426355012622 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426355012623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355012624 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355012625 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426355012626 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426355012627 active site 426355012628 beta-ketothiolase; Provisional; Region: PRK09051 426355012629 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 426355012630 dimer interface [polypeptide binding]; other site 426355012631 active site 426355012632 Phosphotransferase enzyme family; Region: APH; pfam01636 426355012633 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 426355012634 putative active site [active] 426355012635 putative substrate binding site [chemical binding]; other site 426355012636 ATP binding site [chemical binding]; other site 426355012637 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 426355012638 CsbD-like; Region: CsbD; pfam05532 426355012639 CsbD-like; Region: CsbD; pfam05532 426355012640 PAS domain; Region: PAS_9; pfam13426 426355012641 PAS domain S-box; Region: sensory_box; TIGR00229 426355012642 PAS domain S-box; Region: sensory_box; TIGR00229 426355012643 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355012644 putative active site [active] 426355012645 heme pocket [chemical binding]; other site 426355012646 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426355012647 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355012648 DNA binding residues [nucleotide binding] 426355012649 dimerization interface [polypeptide binding]; other site 426355012650 RNA polymerase sigma factor; Provisional; Region: PRK12546 426355012651 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 426355012652 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 426355012653 active site 426355012654 catalytic site [active] 426355012655 YGGT family; Region: YGGT; pfam02325 426355012656 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 426355012657 putative active site [active] 426355012658 putative catalytic site [active] 426355012659 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 426355012660 putative active site [active] 426355012661 putative catalytic site [active] 426355012662 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 426355012663 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 426355012664 Predicted transcriptional regulators [Transcription]; Region: COG1733 426355012665 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 426355012666 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 426355012667 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 426355012668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426355012669 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426355012670 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 426355012671 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355012672 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355012673 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 426355012674 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 426355012675 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426355012676 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426355012677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355012678 dimer interface [polypeptide binding]; other site 426355012679 conserved gate region; other site 426355012680 putative PBP binding loops; other site 426355012681 ABC-ATPase subunit interface; other site 426355012682 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 426355012683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355012684 dimer interface [polypeptide binding]; other site 426355012685 conserved gate region; other site 426355012686 putative PBP binding loops; other site 426355012687 ABC-ATPase subunit interface; other site 426355012688 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 426355012689 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355012690 Walker A/P-loop; other site 426355012691 ATP binding site [chemical binding]; other site 426355012692 Q-loop/lid; other site 426355012693 ABC transporter signature motif; other site 426355012694 Walker B; other site 426355012695 D-loop; other site 426355012696 H-loop/switch region; other site 426355012697 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426355012698 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 426355012699 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355012700 Walker A/P-loop; other site 426355012701 ATP binding site [chemical binding]; other site 426355012702 Q-loop/lid; other site 426355012703 ABC transporter signature motif; other site 426355012704 Walker B; other site 426355012705 D-loop; other site 426355012706 H-loop/switch region; other site 426355012707 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 426355012708 CrcB-like protein; Region: CRCB; cl09114 426355012709 MEKHLA domain; Region: MEKHLA; pfam08670 426355012710 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355012711 putative active site [active] 426355012712 heme pocket [chemical binding]; other site 426355012713 Major royal jelly protein; Region: MRJP; pfam03022 426355012714 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 426355012715 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426355012716 hypothetical protein; Validated; Region: PRK09104 426355012717 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 426355012718 metal binding site [ion binding]; metal-binding site 426355012719 putative dimer interface [polypeptide binding]; other site 426355012720 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 426355012721 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 426355012722 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426355012723 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 426355012724 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 426355012725 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426355012726 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426355012727 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355012728 Predicted membrane protein [Function unknown]; Region: COG2510 426355012729 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426355012730 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 426355012731 C-terminal domain interface [polypeptide binding]; other site 426355012732 GSH binding site (G-site) [chemical binding]; other site 426355012733 dimer interface [polypeptide binding]; other site 426355012734 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 426355012735 N-terminal domain interface [polypeptide binding]; other site 426355012736 dimer interface [polypeptide binding]; other site 426355012737 substrate binding pocket (H-site) [chemical binding]; other site 426355012738 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 426355012739 Peptidase family M48; Region: Peptidase_M48; pfam01435 426355012740 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426355012741 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355012742 non-specific DNA binding site [nucleotide binding]; other site 426355012743 salt bridge; other site 426355012744 sequence-specific DNA binding site [nucleotide binding]; other site 426355012745 S-adenosylmethionine synthetase; Validated; Region: PRK05250 426355012746 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 426355012747 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 426355012748 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 426355012749 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 426355012750 PAS fold; Region: PAS_3; pfam08447 426355012751 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355012752 putative active site [active] 426355012753 heme pocket [chemical binding]; other site 426355012754 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355012755 HWE histidine kinase; Region: HWE_HK; pfam07536 426355012756 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 426355012757 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 426355012758 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 426355012759 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 426355012760 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 426355012761 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 426355012762 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426355012763 motif II; other site 426355012764 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 426355012765 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 426355012766 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 426355012767 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 426355012768 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 426355012769 catalytic residues [active] 426355012770 argininosuccinate lyase; Provisional; Region: PRK00855 426355012771 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 426355012772 active sites [active] 426355012773 tetramer interface [polypeptide binding]; other site 426355012774 AAA domain; Region: AAA_33; pfam13671 426355012775 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 426355012776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426355012777 active site 426355012778 motif I; other site 426355012779 motif II; other site 426355012780 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355012781 PAS domain; Region: PAS_9; pfam13426 426355012782 putative active site [active] 426355012783 heme pocket [chemical binding]; other site 426355012784 methionine sulfoxide reductase A; Provisional; Region: PRK00058 426355012785 hypothetical protein; Provisional; Region: PRK06834 426355012786 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 426355012787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355012788 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 426355012789 PRC-barrel domain; Region: PRC; pfam05239 426355012790 Putative ParB-like nuclease; Region: ParBc_2; cl17538 426355012791 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 426355012792 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 426355012793 fumarate hydratase; Reviewed; Region: fumC; PRK00485 426355012794 Class II fumarases; Region: Fumarase_classII; cd01362 426355012795 active site 426355012796 tetramer interface [polypeptide binding]; other site 426355012797 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 426355012798 Cytochrome P450; Region: p450; cl12078 426355012799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 426355012800 thymidylate synthase; Reviewed; Region: thyA; PRK01827 426355012801 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 426355012802 dimerization interface [polypeptide binding]; other site 426355012803 active site 426355012804 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 426355012805 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 426355012806 NADP+ binding site [chemical binding]; other site 426355012807 folate binding site [chemical binding]; other site 426355012808 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 426355012809 HflK protein; Region: hflK; TIGR01933 426355012810 HflC protein; Region: hflC; TIGR01932 426355012811 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 426355012812 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 426355012813 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426355012814 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426355012815 protein binding site [polypeptide binding]; other site 426355012816 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426355012817 protein binding site [polypeptide binding]; other site 426355012818 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 426355012819 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 426355012820 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426355012821 motif II; other site 426355012822 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 426355012823 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 426355012824 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 426355012825 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426355012826 carbon starvation protein A; Provisional; Region: PRK15015 426355012827 Carbon starvation protein CstA; Region: CstA; pfam02554 426355012828 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 426355012829 Protein of unknown function (DUF466); Region: DUF466; pfam04328 426355012830 tellurite resistance protein terB; Region: terB; cd07176 426355012831 putative metal binding site [ion binding]; other site 426355012832 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 426355012833 cyanate hydratase; Validated; Region: PRK02866 426355012834 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 426355012835 oligomer interface [polypeptide binding]; other site 426355012836 active site 426355012837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 426355012838 PAS domain; Region: PAS_9; pfam13426 426355012839 putative active site [active] 426355012840 heme pocket [chemical binding]; other site 426355012841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355012842 PAS domain; Region: PAS_9; pfam13426 426355012843 putative active site [active] 426355012844 heme pocket [chemical binding]; other site 426355012845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355012846 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426355012847 Walker A motif; other site 426355012848 ATP binding site [chemical binding]; other site 426355012849 Walker B motif; other site 426355012850 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355012851 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355012852 ligand binding site [chemical binding]; other site 426355012853 flexible hinge region; other site 426355012854 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355012855 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 426355012856 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 426355012857 Phosphotransferase enzyme family; Region: APH; pfam01636 426355012858 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 426355012859 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 426355012860 Substrate binding site; other site 426355012861 metal-binding site 426355012862 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426355012863 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 426355012864 active site 426355012865 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 426355012866 active site 426355012867 catalytic residues [active] 426355012868 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 426355012869 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426355012870 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 426355012871 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355012872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355012873 NAD(P) binding site [chemical binding]; other site 426355012874 active site 426355012875 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426355012876 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355012877 Chain length determinant protein; Region: Wzz; pfam02706 426355012878 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 426355012879 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355012880 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 426355012881 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355012882 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 426355012883 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 426355012884 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426355012885 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355012886 active site 426355012887 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355012888 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 426355012889 colanic acid exporter; Provisional; Region: PRK10459 426355012890 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 426355012891 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 426355012892 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 426355012893 SLBB domain; Region: SLBB; pfam10531 426355012894 hypothetical protein; Provisional; Region: PRK07208 426355012895 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426355012896 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355012897 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 426355012898 putative ADP-binding pocket [chemical binding]; other site 426355012899 Bacterial sugar transferase; Region: Bac_transf; pfam02397 426355012900 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 426355012901 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 426355012902 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426355012903 allophanate hydrolase; Provisional; Region: PRK08186 426355012904 Amidase; Region: Amidase; cl11426 426355012905 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 426355012906 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 426355012907 putative active site [active] 426355012908 putative catalytic site [active] 426355012909 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426355012910 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426355012911 Walker A/P-loop; other site 426355012912 ATP binding site [chemical binding]; other site 426355012913 Q-loop/lid; other site 426355012914 ABC transporter signature motif; other site 426355012915 Walker B; other site 426355012916 D-loop; other site 426355012917 H-loop/switch region; other site 426355012918 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426355012919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355012920 dimer interface [polypeptide binding]; other site 426355012921 conserved gate region; other site 426355012922 putative PBP binding loops; other site 426355012923 ABC-ATPase subunit interface; other site 426355012924 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426355012925 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355012926 membrane-bound complex binding site; other site 426355012927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355012928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355012929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426355012930 dimerization interface [polypeptide binding]; other site 426355012931 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355012932 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355012933 DNA binding site [nucleotide binding] 426355012934 Predicted integral membrane protein [Function unknown]; Region: COG5616 426355012935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426355012936 TPR motif; other site 426355012937 binding surface 426355012938 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426355012939 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 426355012940 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355012941 substrate binding pocket [chemical binding]; other site 426355012942 membrane-bound complex binding site; other site 426355012943 hinge residues; other site 426355012944 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 426355012945 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 426355012946 Walker A/P-loop; other site 426355012947 ATP binding site [chemical binding]; other site 426355012948 Q-loop/lid; other site 426355012949 ABC transporter signature motif; other site 426355012950 Walker B; other site 426355012951 D-loop; other site 426355012952 H-loop/switch region; other site 426355012953 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 426355012954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355012955 dimer interface [polypeptide binding]; other site 426355012956 conserved gate region; other site 426355012957 ABC-ATPase subunit interface; other site 426355012958 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 426355012959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 426355012960 dimer interface [polypeptide binding]; other site 426355012961 conserved gate region; other site 426355012962 ABC-ATPase subunit interface; other site 426355012963 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 426355012964 amidohydrolase; Region: amidohydrolases; TIGR01891 426355012965 putative metal binding site [ion binding]; other site 426355012966 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426355012967 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 426355012968 peptide binding site [polypeptide binding]; other site 426355012969 dimer interface [polypeptide binding]; other site 426355012970 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426355012971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355012972 dimer interface [polypeptide binding]; other site 426355012973 conserved gate region; other site 426355012974 putative PBP binding loops; other site 426355012975 ABC-ATPase subunit interface; other site 426355012976 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 426355012977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355012978 dimer interface [polypeptide binding]; other site 426355012979 conserved gate region; other site 426355012980 putative PBP binding loops; other site 426355012981 ABC-ATPase subunit interface; other site 426355012982 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 426355012983 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355012984 Walker A/P-loop; other site 426355012985 ATP binding site [chemical binding]; other site 426355012986 Q-loop/lid; other site 426355012987 ABC transporter signature motif; other site 426355012988 Walker B; other site 426355012989 D-loop; other site 426355012990 H-loop/switch region; other site 426355012991 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426355012992 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355012993 Walker A/P-loop; other site 426355012994 ATP binding site [chemical binding]; other site 426355012995 Q-loop/lid; other site 426355012996 ABC transporter signature motif; other site 426355012997 Walker B; other site 426355012998 D-loop; other site 426355012999 H-loop/switch region; other site 426355013000 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 426355013001 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 426355013002 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355013003 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355013004 metal binding site [ion binding]; metal-binding site 426355013005 active site 426355013006 I-site; other site 426355013007 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 426355013008 Hemin uptake protein hemP; Region: hemP; pfam10636 426355013009 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 426355013010 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 426355013011 intersubunit interface [polypeptide binding]; other site 426355013012 FecCD transport family; Region: FecCD; pfam01032 426355013013 putative PBP binding regions; other site 426355013014 ABC-ATPase subunit interface; other site 426355013015 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 426355013016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355013017 Walker A/P-loop; other site 426355013018 ATP binding site [chemical binding]; other site 426355013019 Q-loop/lid; other site 426355013020 ABC transporter signature motif; other site 426355013021 Walker B; other site 426355013022 D-loop; other site 426355013023 H-loop/switch region; other site 426355013024 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 426355013025 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426355013026 N-terminal plug; other site 426355013027 ligand-binding site [chemical binding]; other site 426355013028 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 426355013029 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 426355013030 active site 426355013031 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 426355013032 active site 426355013033 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 426355013034 Bacterial sugar transferase; Region: Bac_transf; pfam02397 426355013035 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 426355013036 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 426355013037 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 426355013038 active site 426355013039 active site 426355013040 catalytic residues [active] 426355013041 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 426355013042 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 426355013043 active site 426355013044 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 426355013045 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 426355013046 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 426355013047 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 426355013048 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426355013049 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355013050 DNA binding residues [nucleotide binding] 426355013051 dimerization interface [polypeptide binding]; other site 426355013052 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 426355013053 Chain length determinant protein; Region: Wzz; cl15801 426355013054 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 426355013055 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426355013056 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 426355013057 SLBB domain; Region: SLBB; pfam10531 426355013058 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 426355013059 putative trimer interface [polypeptide binding]; other site 426355013060 putative active site [active] 426355013061 putative substrate binding site [chemical binding]; other site 426355013062 putative CoA binding site [chemical binding]; other site 426355013063 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 426355013064 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 426355013065 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 426355013066 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 426355013067 inhibitor-cofactor binding pocket; inhibition site 426355013068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355013069 catalytic residue [active] 426355013070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355013071 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355013072 NAD(P) binding site [chemical binding]; other site 426355013073 active site 426355013074 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 426355013075 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 426355013076 inhibitor-cofactor binding pocket; inhibition site 426355013077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355013078 catalytic residue [active] 426355013079 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 426355013080 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 426355013081 putative active site [active] 426355013082 putative metal binding site [ion binding]; other site 426355013083 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 426355013084 active site 426355013085 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426355013086 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 426355013087 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 426355013088 Walker A/P-loop; other site 426355013089 ATP binding site [chemical binding]; other site 426355013090 Q-loop/lid; other site 426355013091 ABC transporter signature motif; other site 426355013092 Walker B; other site 426355013093 D-loop; other site 426355013094 H-loop/switch region; other site 426355013095 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 426355013096 putative carbohydrate binding site [chemical binding]; other site 426355013097 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 426355013098 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 426355013099 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 426355013100 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 426355013101 Ligand binding site; other site 426355013102 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 426355013103 phosphoglyceromutase; Provisional; Region: PRK05434 426355013104 Uncharacterized conserved protein [Function unknown]; Region: COG0397 426355013105 hypothetical protein; Validated; Region: PRK00029 426355013106 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 426355013107 PRC-barrel domain; Region: PRC; pfam05239 426355013108 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 426355013109 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 426355013110 Cu(I) binding site [ion binding]; other site 426355013111 PilZ domain; Region: PilZ; pfam07238 426355013112 PilZ domain; Region: PilZ; pfam07238 426355013113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 426355013114 PAS domain; Region: PAS_5; pfam07310 426355013115 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 426355013116 FOG: CBS domain [General function prediction only]; Region: COG0517 426355013117 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 426355013118 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 426355013119 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 426355013120 putative active site [active] 426355013121 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 426355013122 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 426355013123 nucleophile elbow; other site 426355013124 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 426355013125 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 426355013126 GTP cyclohydrolase I; Provisional; Region: PLN03044 426355013127 active site 426355013128 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 426355013129 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 426355013130 trimerization site [polypeptide binding]; other site 426355013131 active site 426355013132 hypothetical protein; Validated; Region: PRK00041 426355013133 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 426355013134 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 426355013135 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 426355013136 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 426355013137 Transcriptional regulators [Transcription]; Region: FadR; COG2186 426355013138 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355013139 DNA-binding site [nucleotide binding]; DNA binding site 426355013140 FCD domain; Region: FCD; cl11656 426355013141 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 426355013142 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 426355013143 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 426355013144 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355013145 dimer interface [polypeptide binding]; other site 426355013146 putative CheW interface [polypeptide binding]; other site 426355013147 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 426355013148 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 426355013149 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 426355013150 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 426355013151 Cysteine-rich domain; Region: CCG; pfam02754 426355013152 Cysteine-rich domain; Region: CCG; pfam02754 426355013153 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 426355013154 FAD binding domain; Region: FAD_binding_4; pfam01565 426355013155 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 426355013156 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355013157 putative CheW interface [polypeptide binding]; other site 426355013158 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 426355013159 speF leader as predicted by Rfam (RF00518), score 95.98 426355013160 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 426355013161 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 426355013162 dimer interface [polypeptide binding]; other site 426355013163 active site 426355013164 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426355013165 catalytic residues [active] 426355013166 substrate binding site [chemical binding]; other site 426355013167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426355013168 Coenzyme A binding pocket [chemical binding]; other site 426355013169 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 426355013170 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 426355013171 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 426355013172 active site 426355013173 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 426355013174 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 426355013175 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426355013176 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 426355013177 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355013178 putative active site [active] 426355013179 heme pocket [chemical binding]; other site 426355013180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355013181 dimer interface [polypeptide binding]; other site 426355013182 phosphorylation site [posttranslational modification] 426355013183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355013184 ATP binding site [chemical binding]; other site 426355013185 Mg2+ binding site [ion binding]; other site 426355013186 G-X-G motif; other site 426355013187 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 426355013188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426355013189 Coenzyme A binding pocket [chemical binding]; other site 426355013190 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355013191 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 426355013192 CoenzymeA binding site [chemical binding]; other site 426355013193 subunit interaction site [polypeptide binding]; other site 426355013194 PHB binding site; other site 426355013195 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 426355013196 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 426355013197 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 426355013198 AAA domain; Region: AAA_30; pfam13604 426355013199 Family description; Region: UvrD_C_2; pfam13538 426355013200 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 426355013201 Part of AAA domain; Region: AAA_19; pfam13245 426355013202 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 426355013203 AAA domain; Region: AAA_30; pfam13604 426355013204 AAA domain; Region: AAA_12; pfam13087 426355013205 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 426355013206 putative active site [active] 426355013207 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 426355013208 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 426355013209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355013210 Walker A motif; other site 426355013211 ATP binding site [chemical binding]; other site 426355013212 Walker B motif; other site 426355013213 arginine finger; other site 426355013214 Peptidase family M41; Region: Peptidase_M41; pfam01434 426355013215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 426355013216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 426355013217 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 426355013218 potassium-tellurite ethidium and proflavin transporter; Provisional; Region: PRK10764 426355013219 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 426355013220 gating phenylalanine in ion channel; other site 426355013221 short chain dehydrogenase; Provisional; Region: PRK06180 426355013222 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 426355013223 NADP binding site [chemical binding]; other site 426355013224 active site 426355013225 steroid binding site; other site 426355013226 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426355013227 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426355013228 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355013229 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355013230 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 426355013231 putative effector binding pocket; other site 426355013232 putative dimerization interface [polypeptide binding]; other site 426355013233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 426355013234 SnoaL-like domain; Region: SnoaL_2; pfam12680 426355013235 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 426355013236 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 426355013237 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 426355013238 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 426355013239 FAD binding pocket [chemical binding]; other site 426355013240 FAD binding motif [chemical binding]; other site 426355013241 phosphate binding motif [ion binding]; other site 426355013242 beta-alpha-beta structure motif; other site 426355013243 NAD binding pocket [chemical binding]; other site 426355013244 Heme binding pocket [chemical binding]; other site 426355013245 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426355013246 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 426355013247 putative C-terminal domain interface [polypeptide binding]; other site 426355013248 putative GSH binding site (G-site) [chemical binding]; other site 426355013249 putative dimer interface [polypeptide binding]; other site 426355013250 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 426355013251 putative N-terminal domain interface [polypeptide binding]; other site 426355013252 putative dimer interface [polypeptide binding]; other site 426355013253 putative substrate binding pocket (H-site) [chemical binding]; other site 426355013254 Isochorismatase family; Region: Isochorismatase; pfam00857 426355013255 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 426355013256 catalytic triad [active] 426355013257 conserved cis-peptide bond; other site 426355013258 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355013259 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355013260 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 426355013261 putative effector binding pocket; other site 426355013262 dimerization interface [polypeptide binding]; other site 426355013263 Pirin-related protein [General function prediction only]; Region: COG1741 426355013264 Pirin; Region: Pirin; pfam02678 426355013265 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 426355013266 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 426355013267 DPS ferroxidase diiron center [ion binding]; other site 426355013268 dimerization interface [polypeptide binding]; other site 426355013269 ion pore; other site 426355013270 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 426355013271 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 426355013272 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426355013273 cyclase homology domain; Region: CHD; cd07302 426355013274 nucleotidyl binding site; other site 426355013275 metal binding site [ion binding]; metal-binding site 426355013276 dimer interface [polypeptide binding]; other site 426355013277 Predicted integral membrane protein [Function unknown]; Region: COG5616 426355013278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426355013279 TPR motif; other site 426355013280 binding surface 426355013281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426355013282 TPR repeat; Region: TPR_11; pfam13414 426355013283 binding surface 426355013284 TPR motif; other site 426355013285 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 426355013286 Domain of unknown function DUF302; Region: DUF302; pfam03625 426355013287 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426355013288 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 426355013289 Cupin; Region: Cupin_6; pfam12852 426355013290 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426355013291 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355013292 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 426355013293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426355013294 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 426355013295 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 426355013296 malonyl-CoA binding site [chemical binding]; other site 426355013297 dimer interface [polypeptide binding]; other site 426355013298 active site 426355013299 product binding site; other site 426355013300 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 426355013301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355013302 putative substrate translocation pore; other site 426355013303 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426355013304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355013305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355013306 dimer interface [polypeptide binding]; other site 426355013307 phosphorylation site [posttranslational modification] 426355013308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355013309 ATP binding site [chemical binding]; other site 426355013310 Mg2+ binding site [ion binding]; other site 426355013311 G-X-G motif; other site 426355013312 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426355013313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355013314 active site 426355013315 phosphorylation site [posttranslational modification] 426355013316 intermolecular recognition site; other site 426355013317 dimerization interface [polypeptide binding]; other site 426355013318 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355013319 DNA binding residues [nucleotide binding] 426355013320 dimerization interface [polypeptide binding]; other site 426355013321 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426355013322 Serine hydrolase; Region: Ser_hydrolase; cl17834 426355013323 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 426355013324 classical (c) SDRs; Region: SDR_c; cd05233 426355013325 NAD(P) binding site [chemical binding]; other site 426355013326 active site 426355013327 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 426355013328 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 426355013329 conserved cys residue [active] 426355013330 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355013331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355013332 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 426355013333 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426355013334 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 426355013335 Na binding site [ion binding]; other site 426355013336 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 426355013337 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426355013338 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426355013339 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355013340 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 426355013341 putative hydrophobic ligand binding site [chemical binding]; other site 426355013342 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 426355013343 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 426355013344 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 426355013345 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 426355013346 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426355013347 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 426355013348 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426355013349 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426355013350 acyl-activating enzyme (AAE) consensus motif; other site 426355013351 acyl-activating enzyme (AAE) consensus motif; other site 426355013352 AMP binding site [chemical binding]; other site 426355013353 active site 426355013354 CoA binding site [chemical binding]; other site 426355013355 enoyl-CoA hydratase; Provisional; Region: PRK06688 426355013356 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426355013357 substrate binding site [chemical binding]; other site 426355013358 oxyanion hole (OAH) forming residues; other site 426355013359 trimer interface [polypeptide binding]; other site 426355013360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355013361 putative substrate translocation pore; other site 426355013362 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 426355013363 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 426355013364 Flavoprotein; Region: Flavoprotein; pfam02441 426355013365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355013366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355013367 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 426355013368 putative dimerization interface [polypeptide binding]; other site 426355013369 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 426355013370 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 426355013371 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 426355013372 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426355013373 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 426355013374 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 426355013375 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 426355013376 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 426355013377 putative active site [active] 426355013378 hypothetical protein; Provisional; Region: PRK07483 426355013379 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 426355013380 inhibitor-cofactor binding pocket; inhibition site 426355013381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355013382 catalytic residue [active] 426355013383 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 426355013384 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355013385 substrate binding pocket [chemical binding]; other site 426355013386 membrane-bound complex binding site; other site 426355013387 hinge residues; other site 426355013388 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 426355013389 HTH-like domain; Region: HTH_21; pfam13276 426355013390 Integrase core domain; Region: rve; pfam00665 426355013391 Integrase core domain; Region: rve_3; pfam13683 426355013392 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 426355013393 DNA-binding interface [nucleotide binding]; DNA binding site 426355013394 Winged helix-turn helix; Region: HTH_29; pfam13551 426355013395 Domain of unknown function DUF302; Region: DUF302; pfam03625 426355013396 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355013397 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355013398 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 426355013399 putative substrate binding pocket [chemical binding]; other site 426355013400 putative dimerization interface [polypeptide binding]; other site 426355013401 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426355013402 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 426355013403 PilZ domain; Region: PilZ; pfam07238 426355013404 Porin subfamily; Region: Porin_2; pfam02530 426355013405 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426355013406 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 426355013407 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 426355013408 N-terminal domain interface [polypeptide binding]; other site 426355013409 dimer interface [polypeptide binding]; other site 426355013410 substrate binding pocket (H-site) [chemical binding]; other site 426355013411 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355013412 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355013413 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 426355013414 putative effector binding pocket; other site 426355013415 dimerization interface [polypeptide binding]; other site 426355013416 Integrase core domain; Region: rve; pfam00665 426355013417 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 426355013418 AAA domain; Region: AAA_22; pfam13401 426355013419 TniQ; Region: TniQ; pfam06527 426355013420 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 426355013421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355013422 DNA-binding site [nucleotide binding]; DNA binding site 426355013423 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426355013424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355013425 homodimer interface [polypeptide binding]; other site 426355013426 catalytic residue [active] 426355013427 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 426355013428 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426355013429 NAD(P) binding site [chemical binding]; other site 426355013430 catalytic residues [active] 426355013431 SnoaL-like domain; Region: SnoaL_2; pfam12680 426355013432 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 426355013433 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 426355013434 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 426355013435 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355013436 Walker A/P-loop; other site 426355013437 ATP binding site [chemical binding]; other site 426355013438 Q-loop/lid; other site 426355013439 ABC transporter signature motif; other site 426355013440 Walker B; other site 426355013441 D-loop; other site 426355013442 H-loop/switch region; other site 426355013443 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426355013444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 426355013445 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355013446 Walker A/P-loop; other site 426355013447 ATP binding site [chemical binding]; other site 426355013448 Q-loop/lid; other site 426355013449 ABC transporter signature motif; other site 426355013450 Walker B; other site 426355013451 D-loop; other site 426355013452 H-loop/switch region; other site 426355013453 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 426355013454 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 426355013455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355013456 dimer interface [polypeptide binding]; other site 426355013457 conserved gate region; other site 426355013458 putative PBP binding loops; other site 426355013459 ABC-ATPase subunit interface; other site 426355013460 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426355013461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355013462 dimer interface [polypeptide binding]; other site 426355013463 conserved gate region; other site 426355013464 putative PBP binding loops; other site 426355013465 ABC-ATPase subunit interface; other site 426355013466 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426355013467 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 426355013468 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 426355013469 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 426355013470 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 426355013471 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 426355013472 active site 426355013473 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355013474 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355013475 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 426355013476 dimerization interface [polypeptide binding]; other site 426355013477 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 426355013478 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426355013479 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426355013480 Epoxide hydrolase N terminus; Region: EHN; pfam06441 426355013481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426355013482 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 426355013483 active site 426355013484 metal binding site [ion binding]; metal-binding site 426355013485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426355013486 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426355013487 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 426355013488 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426355013489 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 426355013490 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 426355013491 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 426355013492 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355013493 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355013494 ligand binding site [chemical binding]; other site 426355013495 flexible hinge region; other site 426355013496 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426355013497 putative switch regulator; other site 426355013498 non-specific DNA interactions [nucleotide binding]; other site 426355013499 DNA binding site [nucleotide binding] 426355013500 sequence specific DNA binding site [nucleotide binding]; other site 426355013501 putative cAMP binding site [chemical binding]; other site 426355013502 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 426355013503 Predicted transcriptional regulators [Transcription]; Region: COG1510 426355013504 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426355013505 putative DNA binding site [nucleotide binding]; other site 426355013506 putative Zn2+ binding site [ion binding]; other site 426355013507 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 426355013508 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 426355013509 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426355013510 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426355013511 active site 426355013512 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 426355013513 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 426355013514 PAS fold; Region: PAS_7; pfam12860 426355013515 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355013516 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355013517 metal binding site [ion binding]; metal-binding site 426355013518 active site 426355013519 I-site; other site 426355013520 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355013521 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355013522 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355013523 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 426355013524 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 426355013525 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426355013526 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355013527 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 426355013528 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 426355013529 FAD binding domain; Region: FAD_binding_4; pfam01565 426355013530 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 426355013531 nucleoside/Zn binding site; other site 426355013532 dimer interface [polypeptide binding]; other site 426355013533 catalytic motif [active] 426355013534 Response regulator receiver domain; Region: Response_reg; pfam00072 426355013535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355013536 active site 426355013537 phosphorylation site [posttranslational modification] 426355013538 intermolecular recognition site; other site 426355013539 dimerization interface [polypeptide binding]; other site 426355013540 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 426355013541 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 426355013542 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 426355013543 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 426355013544 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 426355013545 DXD motif; other site 426355013546 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426355013547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355013548 active site 426355013549 phosphorylation site [posttranslational modification] 426355013550 intermolecular recognition site; other site 426355013551 dimerization interface [polypeptide binding]; other site 426355013552 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355013553 DNA binding residues [nucleotide binding] 426355013554 PAS domain; Region: PAS; smart00091 426355013555 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 426355013556 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 426355013557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355013558 dimer interface [polypeptide binding]; other site 426355013559 phosphorylation site [posttranslational modification] 426355013560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355013561 ATP binding site [chemical binding]; other site 426355013562 Mg2+ binding site [ion binding]; other site 426355013563 G-X-G motif; other site 426355013564 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355013565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355013566 active site 426355013567 phosphorylation site [posttranslational modification] 426355013568 intermolecular recognition site; other site 426355013569 dimerization interface [polypeptide binding]; other site 426355013570 PilZ domain; Region: PilZ; pfam07238 426355013571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 426355013572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 426355013573 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 426355013574 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 426355013575 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 426355013576 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 426355013577 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 426355013578 active site 426355013579 FMN binding site [chemical binding]; other site 426355013580 substrate binding site [chemical binding]; other site 426355013581 3Fe-4S cluster binding site [ion binding]; other site 426355013582 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 426355013583 domain_subunit interface; other site 426355013584 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 426355013585 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 426355013586 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 426355013587 active site 426355013588 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426355013589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355013590 non-specific DNA binding site [nucleotide binding]; other site 426355013591 salt bridge; other site 426355013592 sequence-specific DNA binding site [nucleotide binding]; other site 426355013593 Cupin domain; Region: Cupin_2; pfam07883 426355013594 Response regulator receiver domain; Region: Response_reg; pfam00072 426355013595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355013596 active site 426355013597 phosphorylation site [posttranslational modification] 426355013598 intermolecular recognition site; other site 426355013599 dimerization interface [polypeptide binding]; other site 426355013600 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355013601 dimer interface [polypeptide binding]; other site 426355013602 putative CheW interface [polypeptide binding]; other site 426355013603 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 426355013604 putative binding surface; other site 426355013605 active site 426355013606 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 426355013607 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 426355013608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355013609 ATP binding site [chemical binding]; other site 426355013610 Mg2+ binding site [ion binding]; other site 426355013611 G-X-G motif; other site 426355013612 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 426355013613 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 426355013614 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426355013615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355013616 dimerization interface [polypeptide binding]; other site 426355013617 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426355013618 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355013619 dimer interface [polypeptide binding]; other site 426355013620 putative CheW interface [polypeptide binding]; other site 426355013621 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 426355013622 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 426355013623 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 426355013624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355013625 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 426355013626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355013627 active site 426355013628 phosphorylation site [posttranslational modification] 426355013629 intermolecular recognition site; other site 426355013630 dimerization interface [polypeptide binding]; other site 426355013631 CheB methylesterase; Region: CheB_methylest; pfam01339 426355013632 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 426355013633 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426355013634 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 426355013635 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 426355013636 active site 426355013637 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426355013638 dimer interface [polypeptide binding]; other site 426355013639 substrate binding site [chemical binding]; other site 426355013640 catalytic residues [active] 426355013641 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 426355013642 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426355013643 putative DNA binding site [nucleotide binding]; other site 426355013644 putative Zn2+ binding site [ion binding]; other site 426355013645 AsnC family; Region: AsnC_trans_reg; pfam01037 426355013646 cytosine deaminase; Provisional; Region: PRK05985 426355013647 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 426355013648 active site 426355013649 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355013650 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355013651 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426355013652 dimerization interface [polypeptide binding]; other site 426355013653 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 426355013654 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 426355013655 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426355013656 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 426355013657 NAD(P) binding site [chemical binding]; other site 426355013658 catalytic residues [active] 426355013659 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 426355013660 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 426355013661 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 426355013662 metal binding site [ion binding]; metal-binding site 426355013663 putative dimer interface [polypeptide binding]; other site 426355013664 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 426355013665 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 426355013666 heme binding site [chemical binding]; other site 426355013667 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 426355013668 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 426355013669 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355013670 DNA-binding site [nucleotide binding]; DNA binding site 426355013671 UTRA domain; Region: UTRA; pfam07702 426355013672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355013673 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 426355013674 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426355013675 active site 426355013676 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 426355013677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355013678 putative substrate translocation pore; other site 426355013679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355013680 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426355013681 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426355013682 Walker A/P-loop; other site 426355013683 ATP binding site [chemical binding]; other site 426355013684 Q-loop/lid; other site 426355013685 ABC transporter signature motif; other site 426355013686 Walker B; other site 426355013687 D-loop; other site 426355013688 H-loop/switch region; other site 426355013689 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426355013690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355013691 dimer interface [polypeptide binding]; other site 426355013692 conserved gate region; other site 426355013693 putative PBP binding loops; other site 426355013694 ABC-ATPase subunit interface; other site 426355013695 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 426355013696 NMT1/THI5 like; Region: NMT1; pfam09084 426355013697 substrate binding pocket [chemical binding]; other site 426355013698 membrane-bound complex binding site; other site 426355013699 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426355013700 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 426355013701 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 426355013702 active site 426355013703 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 426355013704 dimer interface [polypeptide binding]; other site 426355013705 non-prolyl cis peptide bond; other site 426355013706 insertion regions; other site 426355013707 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426355013708 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355013709 membrane-bound complex binding site; other site 426355013710 hinge residues; other site 426355013711 Cupin domain; Region: Cupin_2; cl17218 426355013712 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 426355013713 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 426355013714 active site 426355013715 non-prolyl cis peptide bond; other site 426355013716 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355013717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355013718 active site 426355013719 phosphorylation site [posttranslational modification] 426355013720 intermolecular recognition site; other site 426355013721 dimerization interface [polypeptide binding]; other site 426355013722 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 426355013723 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426355013724 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355013725 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355013726 Pirin-related protein [General function prediction only]; Region: COG1741 426355013727 Pirin; Region: Pirin; pfam02678 426355013728 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 426355013729 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426355013730 active site 426355013731 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426355013732 catalytic tetrad [active] 426355013733 HlyD family secretion protein; Region: HlyD; pfam00529 426355013734 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355013735 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355013736 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 426355013737 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 426355013738 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 426355013739 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 426355013740 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 426355013741 malate:quinone oxidoreductase; Validated; Region: PRK05257 426355013742 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 426355013743 Cupin domain; Region: Cupin_2; cl17218 426355013744 pyruvate dehydrogenase; Provisional; Region: PRK09124 426355013745 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 426355013746 PYR/PP interface [polypeptide binding]; other site 426355013747 dimer interface [polypeptide binding]; other site 426355013748 tetramer interface [polypeptide binding]; other site 426355013749 TPP binding site [chemical binding]; other site 426355013750 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426355013751 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 426355013752 TPP-binding site [chemical binding]; other site 426355013753 fumarate hydratase; Reviewed; Region: fumC; PRK00485 426355013754 Class II fumarases; Region: Fumarase_classII; cd01362 426355013755 active site 426355013756 tetramer interface [polypeptide binding]; other site 426355013757 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 426355013758 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426355013759 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 426355013760 Citrate synthase; Region: Citrate_synt; pfam00285 426355013761 dimer interface [polypeptide binding]; other site 426355013762 active site 426355013763 oxalacetate/citrate binding site [chemical binding]; other site 426355013764 citrylCoA binding site [chemical binding]; other site 426355013765 coenzyme A binding site [chemical binding]; other site 426355013766 catalytic triad [active] 426355013767 hypothetical protein; Provisional; Region: PRK06208 426355013768 intersubunit interface [polypeptide binding]; other site 426355013769 active site 426355013770 Zn2+ binding site [ion binding]; other site 426355013771 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 426355013772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355013773 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 426355013774 dimerization interface [polypeptide binding]; other site 426355013775 substrate binding pocket [chemical binding]; other site 426355013776 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 426355013777 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 426355013778 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 426355013779 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355013780 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426355013781 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355013782 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 426355013783 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 426355013784 putative active site [active] 426355013785 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426355013786 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 426355013787 Walker A/P-loop; other site 426355013788 ATP binding site [chemical binding]; other site 426355013789 Q-loop/lid; other site 426355013790 ABC transporter signature motif; other site 426355013791 Walker B; other site 426355013792 D-loop; other site 426355013793 H-loop/switch region; other site 426355013794 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426355013795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355013796 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 426355013797 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426355013798 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426355013799 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355013800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355013801 dimer interface [polypeptide binding]; other site 426355013802 conserved gate region; other site 426355013803 putative PBP binding loops; other site 426355013804 ABC-ATPase subunit interface; other site 426355013805 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 426355013806 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355013807 Walker A/P-loop; other site 426355013808 ATP binding site [chemical binding]; other site 426355013809 Q-loop/lid; other site 426355013810 ABC transporter signature motif; other site 426355013811 Walker B; other site 426355013812 D-loop; other site 426355013813 H-loop/switch region; other site 426355013814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355013815 ABC-ATPase subunit interface; other site 426355013816 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 426355013817 Uncharacterized conserved protein [Function unknown]; Region: COG0397 426355013818 hypothetical protein; Validated; Region: PRK00029 426355013819 short chain dehydrogenase; Provisional; Region: PRK06197 426355013820 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 426355013821 putative NAD(P) binding site [chemical binding]; other site 426355013822 active site 426355013823 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 426355013824 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355013825 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 426355013826 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 426355013827 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 426355013828 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 426355013829 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 426355013830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355013831 S-adenosylmethionine binding site [chemical binding]; other site 426355013832 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 426355013833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426355013834 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 426355013835 Domain of unknown function (DUF305); Region: DUF305; pfam03713 426355013836 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426355013837 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 426355013838 NAD binding site [chemical binding]; other site 426355013839 homotetramer interface [polypeptide binding]; other site 426355013840 homodimer interface [polypeptide binding]; other site 426355013841 active site 426355013842 Protein of unknown function, DUF606; Region: DUF606; pfam04657 426355013843 Protein of unknown function, DUF606; Region: DUF606; pfam04657 426355013844 Predicted membrane protein [Function unknown]; Region: COG1297 426355013845 putative oligopeptide transporter, OPT family; Region: TIGR00733 426355013846 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 426355013847 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 426355013848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355013849 Walker A/P-loop; other site 426355013850 ATP binding site [chemical binding]; other site 426355013851 Q-loop/lid; other site 426355013852 ABC transporter signature motif; other site 426355013853 Walker B; other site 426355013854 D-loop; other site 426355013855 H-loop/switch region; other site 426355013856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355013857 dimer interface [polypeptide binding]; other site 426355013858 conserved gate region; other site 426355013859 putative PBP binding loops; other site 426355013860 ABC-ATPase subunit interface; other site 426355013861 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426355013862 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355013863 substrate binding pocket [chemical binding]; other site 426355013864 membrane-bound complex binding site; other site 426355013865 hinge residues; other site 426355013866 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 426355013867 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 426355013868 inhibitor site; inhibition site 426355013869 active site 426355013870 dimer interface [polypeptide binding]; other site 426355013871 catalytic residue [active] 426355013872 aspartate aminotransferase; Provisional; Region: PRK06108 426355013873 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426355013874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355013875 homodimer interface [polypeptide binding]; other site 426355013876 catalytic residue [active] 426355013877 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 426355013878 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 426355013879 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 426355013880 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 426355013881 Predicted transcriptional regulators [Transcription]; Region: COG1510 426355013882 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426355013883 dimerization interface [polypeptide binding]; other site 426355013884 putative DNA binding site [nucleotide binding]; other site 426355013885 putative Zn2+ binding site [ion binding]; other site 426355013886 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426355013887 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355013888 DNA-binding site [nucleotide binding]; DNA binding site 426355013889 FCD domain; Region: FCD; pfam07729 426355013890 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355013891 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355013892 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 426355013893 putative effector binding pocket; other site 426355013894 dimerization interface [polypeptide binding]; other site 426355013895 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 426355013896 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426355013897 Zn binding site [ion binding]; other site 426355013898 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 426355013899 Zn binding site [ion binding]; other site 426355013900 Predicted esterase [General function prediction only]; Region: COG0400 426355013901 putative hydrolase; Provisional; Region: PRK11460 426355013902 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426355013903 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426355013904 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426355013905 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 426355013906 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 426355013907 active site 426355013908 8-oxo-dGMP binding site [chemical binding]; other site 426355013909 nudix motif; other site 426355013910 metal binding site [ion binding]; metal-binding site 426355013911 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 426355013912 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 426355013913 heterotetramer interface [polypeptide binding]; other site 426355013914 active site pocket [active] 426355013915 cleavage site 426355013916 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 426355013917 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355013918 dimerization interface [polypeptide binding]; other site 426355013919 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355013920 putative CheW interface [polypeptide binding]; other site 426355013921 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 426355013922 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 426355013923 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 426355013924 Membrane fusogenic activity; Region: BMFP; pfam04380 426355013925 PhoH-like protein; Region: PhoH; pfam02562 426355013926 AAA domain; Region: AAA_22; pfam13401 426355013927 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 426355013928 Part of AAA domain; Region: AAA_19; pfam13245 426355013929 Family description; Region: UvrD_C_2; pfam13538 426355013930 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 426355013931 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426355013932 Porin subfamily; Region: Porin_2; pfam02530 426355013933 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 426355013934 PAS domain S-box; Region: sensory_box; TIGR00229 426355013935 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355013936 putative active site [active] 426355013937 heme pocket [chemical binding]; other site 426355013938 Histidine kinase; Region: HisKA_2; pfam07568 426355013939 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 426355013940 Uncharacterized conserved protein [Function unknown]; Region: COG5323 426355013941 Terminase-like family; Region: Terminase_6; pfam03237 426355013942 Phage-related protein [Function unknown]; Region: COG4695 426355013943 Phage portal protein; Region: Phage_portal; pfam04860 426355013944 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 426355013945 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 426355013946 Phage capsid family; Region: Phage_capsid; pfam05065 426355013947 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 426355013948 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 426355013949 dimerization interface [polypeptide binding]; other site 426355013950 DPS ferroxidase diiron center [ion binding]; other site 426355013951 ion pore; other site 426355013952 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 426355013953 cleavage site 426355013954 active site 426355013955 substrate binding sites [chemical binding]; other site 426355013956 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 426355013957 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 426355013958 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 426355013959 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 426355013960 Phage major tail protein 2; Region: Phage_tail_2; cl11463 426355013961 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 426355013962 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 426355013963 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 426355013964 active site 426355013965 iron coordination sites [ion binding]; other site 426355013966 substrate binding pocket [chemical binding]; other site 426355013967 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 426355013968 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 426355013969 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 426355013970 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 426355013971 NlpC/P60 family; Region: NLPC_P60; cl17555 426355013972 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 426355013973 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 426355013974 Putative phage tail protein; Region: Phage-tail_3; pfam13550 426355013975 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 426355013976 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 426355013977 active site 426355013978 catalytic triad [active] 426355013979 oxyanion hole [active] 426355013980 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 426355013981 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355013982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355013983 active site 426355013984 phosphorylation site [posttranslational modification] 426355013985 intermolecular recognition site; other site 426355013986 dimerization interface [polypeptide binding]; other site 426355013987 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355013988 DNA binding site [nucleotide binding] 426355013989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 426355013990 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355013991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 426355013992 dimer interface [polypeptide binding]; other site 426355013993 phosphorylation site [posttranslational modification] 426355013994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355013995 ATP binding site [chemical binding]; other site 426355013996 Mg2+ binding site [ion binding]; other site 426355013997 G-X-G motif; other site 426355013998 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 426355013999 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 426355014000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 426355014001 TPR motif; other site 426355014002 binding surface 426355014003 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 426355014004 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 426355014005 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 426355014006 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 426355014007 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426355014008 putative C-terminal domain interface [polypeptide binding]; other site 426355014009 putative GSH binding site (G-site) [chemical binding]; other site 426355014010 putative dimer interface [polypeptide binding]; other site 426355014011 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 426355014012 putative N-terminal domain interface [polypeptide binding]; other site 426355014013 putative dimer interface [polypeptide binding]; other site 426355014014 putative substrate binding pocket (H-site) [chemical binding]; other site 426355014015 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 426355014016 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 426355014017 putative dimer interface [polypeptide binding]; other site 426355014018 [2Fe-2S] cluster binding site [ion binding]; other site 426355014019 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 426355014020 putative dimer interface [polypeptide binding]; other site 426355014021 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 426355014022 SLBB domain; Region: SLBB; pfam10531 426355014023 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 426355014024 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 426355014025 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355014026 catalytic loop [active] 426355014027 iron binding site [ion binding]; other site 426355014028 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 426355014029 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 426355014030 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 426355014031 [4Fe-4S] binding site [ion binding]; other site 426355014032 molybdopterin cofactor binding site; other site 426355014033 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 426355014034 molybdopterin cofactor binding site; other site 426355014035 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 426355014036 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 426355014037 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 426355014038 AsmA family; Region: AsmA; pfam05170 426355014039 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 426355014040 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 426355014041 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426355014042 two-component response regulator; Provisional; Region: PRK09191 426355014043 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 426355014044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355014045 active site 426355014046 phosphorylation site [posttranslational modification] 426355014047 intermolecular recognition site; other site 426355014048 dimerization interface [polypeptide binding]; other site 426355014049 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 426355014050 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355014051 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355014052 ligand binding site [chemical binding]; other site 426355014053 flexible hinge region; other site 426355014054 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 426355014055 dimer interface [polypeptide binding]; other site 426355014056 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426355014057 metal binding site [ion binding]; metal-binding site 426355014058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426355014059 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426355014060 Staphylococcal nuclease homologues; Region: SNc; smart00318 426355014061 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 426355014062 Catalytic site; other site 426355014063 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 426355014064 acyl carrier protein; Provisional; Region: PRK06508 426355014065 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 426355014066 active site 2 [active] 426355014067 active site 1 [active] 426355014068 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 426355014069 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 426355014070 active site 426355014071 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 426355014072 DNA-binding site [nucleotide binding]; DNA binding site 426355014073 RNA-binding motif; other site 426355014074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426355014075 ATP-NAD kinase; Region: NAD_kinase; pfam01513 426355014076 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 426355014077 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 426355014078 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 426355014079 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 426355014080 DXD motif; other site 426355014081 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 426355014082 putative acyl-acceptor binding pocket; other site 426355014083 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 426355014084 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426355014085 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 426355014086 conserved cys residue [active] 426355014087 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 426355014088 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 426355014089 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 426355014090 ABC-2 type transporter; Region: ABC2_membrane; cl17235 426355014091 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 426355014092 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 426355014093 Walker A/P-loop; other site 426355014094 ATP binding site [chemical binding]; other site 426355014095 Q-loop/lid; other site 426355014096 ABC transporter signature motif; other site 426355014097 Walker B; other site 426355014098 D-loop; other site 426355014099 H-loop/switch region; other site 426355014100 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 426355014101 phytoene desaturase; Region: crtI_fam; TIGR02734 426355014102 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 426355014103 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426355014104 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355014105 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 426355014106 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 426355014107 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 426355014108 dimer interaction site [polypeptide binding]; other site 426355014109 substrate-binding tunnel; other site 426355014110 active site 426355014111 catalytic site [active] 426355014112 substrate binding site [chemical binding]; other site 426355014113 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 426355014114 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 426355014115 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426355014116 active site 426355014117 metal binding site [ion binding]; metal-binding site 426355014118 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 426355014119 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 426355014120 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 426355014121 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 426355014122 AAA domain; Region: AAA_33; pfam13671 426355014123 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 426355014124 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 426355014125 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 426355014126 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 426355014127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355014128 Walker A motif; other site 426355014129 ATP binding site [chemical binding]; other site 426355014130 Walker B motif; other site 426355014131 arginine finger; other site 426355014132 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 426355014133 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 426355014134 flagellar assembly protein H; Validated; Region: fliH; PRK06032 426355014135 Flagellar assembly protein FliH; Region: FliH; pfam02108 426355014136 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 426355014137 MgtE intracellular N domain; Region: MgtE_N; cl15244 426355014138 FliG C-terminal domain; Region: FliG_C; pfam01706 426355014139 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 426355014140 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 426355014141 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 426355014142 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 426355014143 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 426355014144 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 426355014145 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 426355014146 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 426355014147 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 426355014148 Ligand Binding Site [chemical binding]; other site 426355014149 Methyltransferase domain; Region: Methyltransf_31; pfam13847 426355014150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355014151 S-adenosylmethionine binding site [chemical binding]; other site 426355014152 Uncharacterized conserved protein [Function unknown]; Region: COG0398 426355014153 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 426355014154 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355014155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355014156 ATP binding site [chemical binding]; other site 426355014157 Mg2+ binding site [ion binding]; other site 426355014158 G-X-G motif; other site 426355014159 biotin synthase; Region: bioB; TIGR00433 426355014160 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355014161 FeS/SAM binding site; other site 426355014162 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 426355014163 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 426355014164 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355014165 putative CheW interface [polypeptide binding]; other site 426355014166 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 426355014167 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 426355014168 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 426355014169 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 426355014170 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 426355014171 aminotransferase; Validated; Region: PRK09148 426355014172 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 426355014173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355014174 homodimer interface [polypeptide binding]; other site 426355014175 catalytic residue [active] 426355014176 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 426355014177 peptide chain release factor 2; Provisional; Region: PRK07342 426355014178 This domain is found in peptide chain release factors; Region: PCRF; smart00937 426355014179 RF-1 domain; Region: RF-1; pfam00472 426355014180 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 426355014181 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 426355014182 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 426355014183 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355014184 Walker A/P-loop; other site 426355014185 ATP binding site [chemical binding]; other site 426355014186 Q-loop/lid; other site 426355014187 ABC transporter signature motif; other site 426355014188 Walker B; other site 426355014189 D-loop; other site 426355014190 H-loop/switch region; other site 426355014191 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 426355014192 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 426355014193 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355014194 Walker A/P-loop; other site 426355014195 ATP binding site [chemical binding]; other site 426355014196 Q-loop/lid; other site 426355014197 ABC transporter signature motif; other site 426355014198 Walker B; other site 426355014199 D-loop; other site 426355014200 H-loop/switch region; other site 426355014201 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 426355014202 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 426355014203 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 426355014204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 426355014205 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 426355014206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355014207 dimer interface [polypeptide binding]; other site 426355014208 conserved gate region; other site 426355014209 putative PBP binding loops; other site 426355014210 ABC-ATPase subunit interface; other site 426355014211 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426355014212 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 426355014213 PilZ domain; Region: PilZ; pfam07238 426355014214 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 426355014215 Porin subfamily; Region: Porin_2; pfam02530 426355014216 Porin subfamily; Region: Porin_2; pfam02530 426355014217 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 426355014218 citrate-proton symporter; Provisional; Region: PRK15075 426355014219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355014220 putative substrate translocation pore; other site 426355014221 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426355014222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355014223 DNA-binding site [nucleotide binding]; DNA binding site 426355014224 FCD domain; Region: FCD; pfam07729 426355014225 tricarballylate dehydrogenase; Validated; Region: PRK08274 426355014226 hydroxyglutarate oxidase; Provisional; Region: PRK11728 426355014227 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 426355014228 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 426355014229 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 426355014230 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 426355014231 FAD binding site [chemical binding]; other site 426355014232 substrate binding pocket [chemical binding]; other site 426355014233 catalytic base [active] 426355014234 Predicted permeases [General function prediction only]; Region: COG0679 426355014235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355014236 S-adenosylmethionine binding site [chemical binding]; other site 426355014237 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 426355014238 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426355014239 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426355014240 catalytic residue [active] 426355014241 TspO/MBR family; Region: TspO_MBR; pfam03073 426355014242 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 426355014243 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 426355014244 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426355014245 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355014246 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355014247 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 426355014248 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355014249 active site 426355014250 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355014251 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 426355014252 putative ADP-binding pocket [chemical binding]; other site 426355014253 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 426355014254 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 426355014255 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 426355014256 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 426355014257 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 426355014258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 426355014259 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 426355014260 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 426355014261 putative acyltransferase; Provisional; Region: PRK05790 426355014262 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 426355014263 dimer interface [polypeptide binding]; other site 426355014264 active site 426355014265 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 426355014266 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 426355014267 NAD(P) binding site [chemical binding]; other site 426355014268 homotetramer interface [polypeptide binding]; other site 426355014269 homodimer interface [polypeptide binding]; other site 426355014270 active site 426355014271 Microsomal signal peptidase 12 kDa subunit (SPC12); Region: SPC12; pfam06645 426355014272 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 426355014273 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 426355014274 putative active site [active] 426355014275 catalytic site [active] 426355014276 putative metal binding site [ion binding]; other site 426355014277 EamA-like transporter family; Region: EamA; pfam00892 426355014278 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 426355014279 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 426355014280 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 426355014281 catalytic site [active] 426355014282 putative active site [active] 426355014283 putative substrate binding site [chemical binding]; other site 426355014284 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 426355014285 glutamine synthetase; Provisional; Region: glnA; PRK09469 426355014286 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 426355014287 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 426355014288 glutamine synthetase; Region: PLN02284 426355014289 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 426355014290 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 426355014291 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 426355014292 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 426355014293 Nitrogen regulatory protein P-II; Region: P-II; smart00938 426355014294 Uncharacterized conserved protein [Function unknown]; Region: COG0062 426355014295 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 426355014296 putative substrate binding site [chemical binding]; other site 426355014297 putative ATP binding site [chemical binding]; other site 426355014298 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 426355014299 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 426355014300 Multicopper oxidase; Region: Cu-oxidase; pfam00394 426355014301 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 426355014302 trigger factor; Provisional; Region: tig; PRK01490 426355014303 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 426355014304 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 426355014305 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 426355014306 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 426355014307 oligomer interface [polypeptide binding]; other site 426355014308 active site residues [active] 426355014309 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 426355014310 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 426355014311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355014312 Walker A motif; other site 426355014313 ATP binding site [chemical binding]; other site 426355014314 Walker B motif; other site 426355014315 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 426355014316 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 426355014317 Found in ATP-dependent protease La (LON); Region: LON; smart00464 426355014318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355014319 Walker A motif; other site 426355014320 ATP binding site [chemical binding]; other site 426355014321 Walker B motif; other site 426355014322 arginine finger; other site 426355014323 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 426355014324 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 426355014325 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 426355014326 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426355014327 S-formylglutathione hydrolase; Region: PLN02442 426355014328 short chain dehydrogenase; Provisional; Region: PRK07109 426355014329 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 426355014330 putative NAD(P) binding site [chemical binding]; other site 426355014331 active site 426355014332 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 426355014333 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 426355014334 Substrate binding site; other site 426355014335 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 426355014336 selenocysteine synthase; Provisional; Region: PRK04311 426355014337 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 426355014338 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426355014339 catalytic residue [active] 426355014340 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426355014341 MarR family; Region: MarR; pfam01047 426355014342 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 426355014343 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 426355014344 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 426355014345 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 426355014346 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 426355014347 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 426355014348 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 426355014349 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 426355014350 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 426355014351 putative molybdopterin cofactor binding site [chemical binding]; other site 426355014352 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 426355014353 putative molybdopterin cofactor binding site; other site 426355014354 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 426355014355 Domain of unknown function DUF77; Region: DUF77; pfam01910 426355014356 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 426355014357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355014358 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 426355014359 putative dimerization interface [polypeptide binding]; other site 426355014360 putative substrate binding pocket [chemical binding]; other site 426355014361 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 426355014362 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 426355014363 putative active site [active] 426355014364 catalytic residue [active] 426355014365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355014366 D-galactonate transporter; Region: 2A0114; TIGR00893 426355014367 putative substrate translocation pore; other site 426355014368 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 426355014369 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 426355014370 active site 426355014371 tetramer interface [polypeptide binding]; other site 426355014372 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 426355014373 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426355014374 active site 426355014375 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426355014376 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426355014377 Walker A/P-loop; other site 426355014378 ATP binding site [chemical binding]; other site 426355014379 Q-loop/lid; other site 426355014380 ABC transporter signature motif; other site 426355014381 Walker B; other site 426355014382 D-loop; other site 426355014383 H-loop/switch region; other site 426355014384 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426355014385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355014386 dimer interface [polypeptide binding]; other site 426355014387 conserved gate region; other site 426355014388 putative PBP binding loops; other site 426355014389 ABC-ATPase subunit interface; other site 426355014390 NMT1-like family; Region: NMT1_2; pfam13379 426355014391 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426355014392 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 426355014393 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 426355014394 SPFH domain / Band 7 family; Region: Band_7; pfam01145 426355014395 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 426355014396 nudix motif; other site 426355014397 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 426355014398 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 426355014399 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 426355014400 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 426355014401 metal ion-dependent adhesion site (MIDAS); other site 426355014402 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 426355014403 active site 426355014404 catalytic site [active] 426355014405 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355014406 non-specific DNA binding site [nucleotide binding]; other site 426355014407 salt bridge; other site 426355014408 sequence-specific DNA binding site [nucleotide binding]; other site 426355014409 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 426355014410 polymerase nucleotide-binding site; other site 426355014411 DNA-binding residues [nucleotide binding]; DNA binding site 426355014412 nucleotide binding site [chemical binding]; other site 426355014413 primase nucleotide-binding site [nucleotide binding]; other site 426355014414 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 426355014415 hypothetical protein; Provisional; Region: PRK14709 426355014416 D5 N terminal like; Region: D5_N; smart00885 426355014417 Helix-turn-helix domain; Region: HTH_17; cl17695 426355014418 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 426355014419 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355014420 DDE superfamily endonuclease; Region: DDE_3; pfam13358 426355014421 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 426355014422 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 426355014423 DNA binding site [nucleotide binding] 426355014424 Int/Topo IB signature motif; other site 426355014425 active site 426355014426 catalytic residues [active] 426355014427 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 426355014428 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426355014429 DNA binding site [nucleotide binding] 426355014430 Int/Topo IB signature motif; other site 426355014431 active site 426355014432 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 426355014433 putative active site [active] 426355014434 putative metal binding site [ion binding]; other site 426355014435 plasmid partitioning protein; Provisional; Region: PRK13832 426355014436 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 426355014437 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 426355014438 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 426355014439 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 426355014440 DPS ferroxidase diiron center [ion binding]; other site 426355014441 dimerization interface [polypeptide binding]; other site 426355014442 ion pore; other site 426355014443 GAF domain; Region: GAF; pfam01590 426355014444 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426355014445 PAS fold; Region: PAS_4; pfam08448 426355014446 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355014447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355014448 dimer interface [polypeptide binding]; other site 426355014449 phosphorylation site [posttranslational modification] 426355014450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355014451 ATP binding site [chemical binding]; other site 426355014452 Mg2+ binding site [ion binding]; other site 426355014453 G-X-G motif; other site 426355014454 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355014455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355014456 active site 426355014457 phosphorylation site [posttranslational modification] 426355014458 intermolecular recognition site; other site 426355014459 dimerization interface [polypeptide binding]; other site 426355014460 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 426355014461 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355014462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355014463 dimer interface [polypeptide binding]; other site 426355014464 phosphorylation site [posttranslational modification] 426355014465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355014466 ATP binding site [chemical binding]; other site 426355014467 Mg2+ binding site [ion binding]; other site 426355014468 G-X-G motif; other site 426355014469 Response regulator receiver domain; Region: Response_reg; pfam00072 426355014470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355014471 active site 426355014472 phosphorylation site [posttranslational modification] 426355014473 intermolecular recognition site; other site 426355014474 dimerization interface [polypeptide binding]; other site 426355014475 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355014476 PAS domain; Region: PAS_9; pfam13426 426355014477 putative active site [active] 426355014478 heme pocket [chemical binding]; other site 426355014479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 426355014480 dimer interface [polypeptide binding]; other site 426355014481 phosphorylation site [posttranslational modification] 426355014482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355014483 ATP binding site [chemical binding]; other site 426355014484 Mg2+ binding site [ion binding]; other site 426355014485 G-X-G motif; other site 426355014486 Response regulator receiver domain; Region: Response_reg; pfam00072 426355014487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355014488 active site 426355014489 phosphorylation site [posttranslational modification] 426355014490 intermolecular recognition site; other site 426355014491 dimerization interface [polypeptide binding]; other site 426355014492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355014493 Response regulator receiver domain; Region: Response_reg; pfam00072 426355014494 active site 426355014495 phosphorylation site [posttranslational modification] 426355014496 intermolecular recognition site; other site 426355014497 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355014498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355014499 dimer interface [polypeptide binding]; other site 426355014500 phosphorylation site [posttranslational modification] 426355014501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355014502 ATP binding site [chemical binding]; other site 426355014503 Mg2+ binding site [ion binding]; other site 426355014504 G-X-G motif; other site 426355014505 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 426355014506 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426355014507 GAF domain; Region: GAF; pfam01590 426355014508 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355014509 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 426355014510 putative active site [active] 426355014511 heme pocket [chemical binding]; other site 426355014512 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355014513 putative active site [active] 426355014514 heme pocket [chemical binding]; other site 426355014515 PAS fold; Region: PAS_4; pfam08448 426355014516 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355014517 PAS fold; Region: PAS_3; pfam08447 426355014518 putative active site [active] 426355014519 heme pocket [chemical binding]; other site 426355014520 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 426355014521 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355014522 putative active site [active] 426355014523 heme pocket [chemical binding]; other site 426355014524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355014525 dimer interface [polypeptide binding]; other site 426355014526 phosphorylation site [posttranslational modification] 426355014527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355014528 ATP binding site [chemical binding]; other site 426355014529 Mg2+ binding site [ion binding]; other site 426355014530 G-X-G motif; other site 426355014531 Response regulator receiver domain; Region: Response_reg; pfam00072 426355014532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355014533 active site 426355014534 phosphorylation site [posttranslational modification] 426355014535 intermolecular recognition site; other site 426355014536 dimerization interface [polypeptide binding]; other site 426355014537 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 426355014538 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 426355014539 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 426355014540 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 426355014541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355014542 ATP binding site [chemical binding]; other site 426355014543 Mg2+ binding site [ion binding]; other site 426355014544 G-X-G motif; other site 426355014545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355014546 ATP binding site [chemical binding]; other site 426355014547 Mg2+ binding site [ion binding]; other site 426355014548 G-X-G motif; other site 426355014549 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 426355014550 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 426355014551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 426355014552 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355014553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355014554 dimer interface [polypeptide binding]; other site 426355014555 phosphorylation site [posttranslational modification] 426355014556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355014557 ATP binding site [chemical binding]; other site 426355014558 G-X-G motif; other site 426355014559 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355014560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355014561 active site 426355014562 phosphorylation site [posttranslational modification] 426355014563 intermolecular recognition site; other site 426355014564 dimerization interface [polypeptide binding]; other site 426355014565 PAS domain; Region: PAS_9; pfam13426 426355014566 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426355014567 GAF domain; Region: GAF; pfam01590 426355014568 PAS fold; Region: PAS_4; pfam08448 426355014569 PAS domain S-box; Region: sensory_box; TIGR00229 426355014570 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355014571 putative active site [active] 426355014572 heme pocket [chemical binding]; other site 426355014573 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355014574 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355014575 dimer interface [polypeptide binding]; other site 426355014576 phosphorylation site [posttranslational modification] 426355014577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355014578 ATP binding site [chemical binding]; other site 426355014579 Mg2+ binding site [ion binding]; other site 426355014580 G-X-G motif; other site 426355014581 Response regulator receiver domain; Region: Response_reg; pfam00072 426355014582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355014583 active site 426355014584 phosphorylation site [posttranslational modification] 426355014585 intermolecular recognition site; other site 426355014586 dimerization interface [polypeptide binding]; other site 426355014587 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355014588 dimerization interface [polypeptide binding]; other site 426355014589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355014590 HWE histidine kinase; Region: HWE_HK; pfam07536 426355014591 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426355014592 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355014593 Domain of unknown function (DUF892); Region: DUF892; pfam05974 426355014594 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 426355014595 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 426355014596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355014597 putative substrate translocation pore; other site 426355014598 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 426355014599 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355014600 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355014601 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355014602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426355014603 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 426355014604 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 426355014605 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426355014606 substrate binding site [chemical binding]; other site 426355014607 oxyanion hole (OAH) forming residues; other site 426355014608 trimer interface [polypeptide binding]; other site 426355014609 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 426355014610 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 426355014611 putative metal binding site [ion binding]; other site 426355014612 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 426355014613 active site 426355014614 Uncharacterized conserved protein [Function unknown]; Region: COG2353 426355014615 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 426355014616 Uncharacterized conserved protein [Function unknown]; Region: COG2353 426355014617 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355014618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355014619 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 426355014620 putative effector binding pocket; other site 426355014621 dimerization interface [polypeptide binding]; other site 426355014622 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 426355014623 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 426355014624 NADP binding site [chemical binding]; other site 426355014625 Predicted transcriptional regulators [Transcription]; Region: COG1733 426355014626 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 426355014627 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 426355014628 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426355014629 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 426355014630 Domain of unknown function (DUF305); Region: DUF305; cl17794 426355014631 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 426355014632 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 426355014633 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 426355014634 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355014635 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426355014636 DNA binding residues [nucleotide binding] 426355014637 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 426355014638 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 426355014639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355014640 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 426355014641 putative dimerization interface [polypeptide binding]; other site 426355014642 sulfite oxidase; Provisional; Region: PLN00177 426355014643 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 426355014644 Moco binding site; other site 426355014645 metal coordination site [ion binding]; other site 426355014646 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 426355014647 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 426355014648 structural tetrad; other site 426355014649 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 426355014650 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 426355014651 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 426355014652 Moco binding site; other site 426355014653 metal coordination site [ion binding]; other site 426355014654 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426355014655 cyclase homology domain; Region: CHD; cd07302 426355014656 nucleotidyl binding site; other site 426355014657 metal binding site [ion binding]; metal-binding site 426355014658 dimer interface [polypeptide binding]; other site 426355014659 Predicted membrane protein [Function unknown]; Region: COG2855 426355014660 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426355014661 catalytic core [active] 426355014662 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 426355014663 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 426355014664 cobalamin binding residues [chemical binding]; other site 426355014665 putative BtuC binding residues; other site 426355014666 dimer interface [polypeptide binding]; other site 426355014667 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 426355014668 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426355014669 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 426355014670 Protein of unknown function; Region: DUF3658; pfam12395 426355014671 sulfite oxidase; Provisional; Region: PLN00177 426355014672 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 426355014673 Moco binding site; other site 426355014674 metal coordination site [ion binding]; other site 426355014675 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 426355014676 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 426355014677 putative NAD(P) binding site [chemical binding]; other site 426355014678 dimer interface [polypeptide binding]; other site 426355014679 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 426355014680 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355014681 NAD(P) binding site [chemical binding]; other site 426355014682 active site 426355014683 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426355014684 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426355014685 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 426355014686 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 426355014687 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 426355014688 FMN binding site [chemical binding]; other site 426355014689 active site 426355014690 substrate binding site [chemical binding]; other site 426355014691 catalytic residue [active] 426355014692 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 426355014693 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 426355014694 intracellular protease, PfpI family; Region: PfpI; TIGR01382 426355014695 proposed catalytic triad [active] 426355014696 conserved cys residue [active] 426355014697 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426355014698 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426355014699 active site 426355014700 catalytic tetrad [active] 426355014701 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 426355014702 active site 426355014703 catalytic residues [active] 426355014704 DNA binding site [nucleotide binding] 426355014705 Int/Topo IB signature motif; other site 426355014706 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 426355014707 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 426355014708 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 426355014709 ATP-dependent protease La; Region: lon; TIGR00763 426355014710 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 426355014711 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 426355014712 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 426355014713 Dehydroquinase class II; Region: DHquinase_II; pfam01220 426355014714 active site 426355014715 trimer interface [polypeptide binding]; other site 426355014716 dimer interface [polypeptide binding]; other site 426355014717 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 426355014718 active site 426355014719 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 426355014720 active site 426355014721 substrate binding pocket [chemical binding]; other site 426355014722 dimer interface [polypeptide binding]; other site 426355014723 amidase; Provisional; Region: PRK07486 426355014724 Amidase; Region: Amidase; cl11426 426355014725 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 426355014726 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426355014727 PYR/PP interface [polypeptide binding]; other site 426355014728 dimer interface [polypeptide binding]; other site 426355014729 TPP binding site [chemical binding]; other site 426355014730 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 426355014731 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 426355014732 TPP-binding site [chemical binding]; other site 426355014733 dimer interface [polypeptide binding]; other site 426355014734 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 426355014735 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 426355014736 putative valine binding site [chemical binding]; other site 426355014737 dimer interface [polypeptide binding]; other site 426355014738 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 426355014739 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 426355014740 glutathionine S-transferase; Provisional; Region: PRK10542 426355014741 C-terminal domain interface [polypeptide binding]; other site 426355014742 GSH binding site (G-site) [chemical binding]; other site 426355014743 dimer interface [polypeptide binding]; other site 426355014744 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 426355014745 dimer interface [polypeptide binding]; other site 426355014746 N-terminal domain interface [polypeptide binding]; other site 426355014747 substrate binding pocket (H-site) [chemical binding]; other site 426355014748 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426355014749 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 426355014750 ketol-acid reductoisomerase; Provisional; Region: PRK05479 426355014751 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 426355014752 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 426355014753 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 426355014754 Cache domain; Region: Cache_1; pfam02743 426355014755 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355014756 dimerization interface [polypeptide binding]; other site 426355014757 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355014758 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426355014759 dimer interface [polypeptide binding]; other site 426355014760 putative CheW interface [polypeptide binding]; other site 426355014761 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 426355014762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355014763 S-adenosylmethionine binding site [chemical binding]; other site 426355014764 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 426355014765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426355014766 motif II; other site 426355014767 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 426355014768 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 426355014769 active site 426355014770 HIGH motif; other site 426355014771 dimer interface [polypeptide binding]; other site 426355014772 KMSKS motif; other site 426355014773 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 426355014774 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 426355014775 minor groove reading motif; other site 426355014776 helix-hairpin-helix signature motif; other site 426355014777 substrate binding pocket [chemical binding]; other site 426355014778 active site 426355014779 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 426355014780 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 426355014781 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 426355014782 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 426355014783 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 426355014784 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 426355014785 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 426355014786 FeS/SAM binding site; other site 426355014787 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 426355014788 active site 426355014789 pseudouridine synthase; Region: TIGR00093 426355014790 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 426355014791 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 426355014792 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 426355014793 P loop; other site 426355014794 GTP binding site [chemical binding]; other site 426355014795 Intracellular septation protein A; Region: IspA; pfam04279 426355014796 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 426355014797 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 426355014798 catalytic residues [active] 426355014799 central insert; other site 426355014800 Heme exporter protein D (CcmD); Region: CcmD; cl11475 426355014801 heme exporter protein CcmC; Region: ccmC; TIGR01191 426355014802 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 426355014803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355014804 S-adenosylmethionine binding site [chemical binding]; other site 426355014805 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 426355014806 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 426355014807 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 426355014808 substrate binding pocket [chemical binding]; other site 426355014809 chain length determination region; other site 426355014810 substrate-Mg2+ binding site; other site 426355014811 catalytic residues [active] 426355014812 aspartate-rich region 1; other site 426355014813 active site lid residues [active] 426355014814 aspartate-rich region 2; other site 426355014815 MarR family; Region: MarR_2; pfam12802 426355014816 Transcriptional regulators [Transcription]; Region: MarR; COG1846 426355014817 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 426355014818 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 426355014819 Cl- selectivity filter; other site 426355014820 Cl- binding residues [ion binding]; other site 426355014821 pore gating glutamate residue; other site 426355014822 dimer interface [polypeptide binding]; other site 426355014823 FOG: CBS domain [General function prediction only]; Region: COG0517 426355014824 CBS domain; Region: CBS; pfam00571 426355014825 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 426355014826 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 426355014827 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 426355014828 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 426355014829 dimer interface [polypeptide binding]; other site 426355014830 putative functional site; other site 426355014831 putative MPT binding site; other site 426355014832 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 426355014833 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 426355014834 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 426355014835 catalytic residue [active] 426355014836 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 426355014837 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 426355014838 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355014839 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355014840 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426355014841 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 426355014842 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 426355014843 Chain length determinant protein; Region: Wzz; pfam02706 426355014844 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 426355014845 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 426355014846 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 426355014847 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426355014848 putative active site [active] 426355014849 metal binding site [ion binding]; metal-binding site 426355014850 homodimer binding site [polypeptide binding]; other site 426355014851 hypothetical protein; Validated; Region: PRK09039 426355014852 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 426355014853 ligand binding site [chemical binding]; other site 426355014854 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426355014855 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 426355014856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355014857 Walker A/P-loop; other site 426355014858 ATP binding site [chemical binding]; other site 426355014859 Q-loop/lid; other site 426355014860 ABC transporter signature motif; other site 426355014861 Walker B; other site 426355014862 D-loop; other site 426355014863 H-loop/switch region; other site 426355014864 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 426355014865 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 426355014866 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 426355014867 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 426355014868 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 426355014869 Protein of unknown function (DUF461); Region: DUF461; pfam04314 426355014870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 426355014871 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426355014872 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426355014873 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 426355014874 active site 426355014875 metal binding site [ion binding]; metal-binding site 426355014876 intracellular protease, PfpI family; Region: PfpI; TIGR01382 426355014877 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 426355014878 proposed catalytic triad [active] 426355014879 conserved cys residue [active] 426355014880 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 426355014881 DNA-binding site [nucleotide binding]; DNA binding site 426355014882 RNA-binding motif; other site 426355014883 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 426355014884 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 426355014885 active site 426355014886 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 426355014887 UbiA prenyltransferase family; Region: UbiA; pfam01040 426355014888 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 426355014889 glutamate--cysteine ligase; Region: PLN02611 426355014890 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 426355014891 CPxP motif; other site 426355014892 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 426355014893 dimer interface [polypeptide binding]; other site 426355014894 ADP-ribose binding site [chemical binding]; other site 426355014895 active site 426355014896 nudix motif; other site 426355014897 metal binding site [ion binding]; metal-binding site 426355014898 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 426355014899 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 426355014900 Chain length determinant protein; Region: Wzz; pfam02706 426355014901 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426355014902 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355014903 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 426355014904 selenophosphate synthetase; Provisional; Region: PRK00943 426355014905 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 426355014906 dimerization interface [polypeptide binding]; other site 426355014907 putative ATP binding site [chemical binding]; other site 426355014908 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 426355014909 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 426355014910 putative active site [active] 426355014911 putative metal binding site [ion binding]; other site 426355014912 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 426355014913 Flagellar protein FlaF; Region: FlaF; cl11454 426355014914 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 426355014915 Flagellar protein FlbT; Region: FlbT; cl11455 426355014916 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426355014917 classical (c) SDRs; Region: SDR_c; cd05233 426355014918 NAD(P) binding site [chemical binding]; other site 426355014919 active site 426355014920 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 426355014921 MoaE interaction surface [polypeptide binding]; other site 426355014922 MoeB interaction surface [polypeptide binding]; other site 426355014923 thiocarboxylated glycine; other site 426355014924 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 426355014925 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 426355014926 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 426355014927 GIY-YIG motif/motif A; other site 426355014928 active site 426355014929 catalytic site [active] 426355014930 putative DNA binding site [nucleotide binding]; other site 426355014931 metal binding site [ion binding]; metal-binding site 426355014932 UvrB/uvrC motif; Region: UVR; pfam02151 426355014933 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 426355014934 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 426355014935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426355014936 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426355014937 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 426355014938 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 426355014939 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 426355014940 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 426355014941 Uncharacterized conserved protein [Function unknown]; Region: COG1565 426355014942 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 426355014943 Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346 426355014944 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426355014945 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 426355014946 active site 426355014947 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 426355014948 Strictosidine synthase; Region: Str_synth; pfam03088 426355014949 Cupin domain; Region: Cupin_2; cl17218 426355014950 replicative DNA helicase; Provisional; Region: PRK09165 426355014951 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 426355014952 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 426355014953 Walker A motif; other site 426355014954 ATP binding site [chemical binding]; other site 426355014955 Walker B motif; other site 426355014956 DNA binding loops [nucleotide binding] 426355014957 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 426355014958 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 426355014959 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 426355014960 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 426355014961 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 426355014962 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 426355014963 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 426355014964 putative NADP binding site [chemical binding]; other site 426355014965 putative substrate binding site [chemical binding]; other site 426355014966 active site 426355014967 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 426355014968 active site lid residues [active] 426355014969 substrate binding pocket [chemical binding]; other site 426355014970 catalytic residues [active] 426355014971 substrate-Mg2+ binding site; other site 426355014972 aspartate-rich region 1; other site 426355014973 aspartate-rich region 2; other site 426355014974 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 426355014975 active site lid residues [active] 426355014976 catalytic residues [active] 426355014977 substrate binding pocket [chemical binding]; other site 426355014978 substrate-Mg2+ binding site; other site 426355014979 aspartate-rich region 1; other site 426355014980 aspartate-rich region 2; other site 426355014981 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 426355014982 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 426355014983 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 426355014984 Active site cavity [active] 426355014985 catalytic acid [active] 426355014986 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 426355014987 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 426355014988 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 426355014989 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426355014990 protein binding site [polypeptide binding]; other site 426355014991 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 426355014992 protein binding site [polypeptide binding]; other site 426355014993 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 426355014994 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 426355014995 HIGH motif; other site 426355014996 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 426355014997 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 426355014998 active site 426355014999 KMSKS motif; other site 426355015000 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 426355015001 tRNA binding surface [nucleotide binding]; other site 426355015002 anticodon binding site; other site 426355015003 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 426355015004 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 426355015005 Outer membrane efflux protein; Region: OEP; pfam02321 426355015006 Outer membrane efflux protein; Region: OEP; pfam02321 426355015007 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 426355015008 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355015009 metal binding site [ion binding]; metal-binding site 426355015010 active site 426355015011 I-site; other site 426355015012 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355015013 spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886 426355015014 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 426355015015 nucleoside/Zn binding site; other site 426355015016 dimer interface [polypeptide binding]; other site 426355015017 catalytic motif [active] 426355015018 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 426355015019 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 426355015020 Strictosidine synthase; Region: Str_synth; pfam03088 426355015021 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 426355015022 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 426355015023 C-terminal domain interface [polypeptide binding]; other site 426355015024 GSH binding site (G-site) [chemical binding]; other site 426355015025 dimer interface [polypeptide binding]; other site 426355015026 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 426355015027 N-terminal domain interface [polypeptide binding]; other site 426355015028 putative dimer interface [polypeptide binding]; other site 426355015029 active site 426355015030 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 426355015031 dimer interface [polypeptide binding]; other site 426355015032 ADP-ribose binding site [chemical binding]; other site 426355015033 active site 426355015034 nudix motif; other site 426355015035 metal binding site [ion binding]; metal-binding site 426355015036 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 426355015037 active site 426355015038 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 426355015039 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 426355015040 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 426355015041 Clp amino terminal domain; Region: Clp_N; pfam02861 426355015042 Clp amino terminal domain; Region: Clp_N; pfam02861 426355015043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355015044 Walker A motif; other site 426355015045 ATP binding site [chemical binding]; other site 426355015046 Walker B motif; other site 426355015047 arginine finger; other site 426355015048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355015049 Walker A motif; other site 426355015050 ATP binding site [chemical binding]; other site 426355015051 Walker B motif; other site 426355015052 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 426355015053 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 426355015054 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 426355015055 MOSC domain; Region: MOSC; pfam03473 426355015056 Cytochrome c; Region: Cytochrom_C; cl11414 426355015057 Cytochrome c; Region: Cytochrom_C; cl11414 426355015058 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 426355015059 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 426355015060 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 426355015061 Methyltransferase domain; Region: Methyltransf_18; pfam12847 426355015062 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 426355015063 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 426355015064 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 426355015065 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 426355015066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355015067 NAD(P) binding site [chemical binding]; other site 426355015068 active site 426355015069 Bacterial transcriptional repressor; Region: TetR; pfam13972 426355015070 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 426355015071 Nucleoside recognition; Region: Gate; pfam07670 426355015072 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 426355015073 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426355015074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355015075 S-adenosylmethionine binding site [chemical binding]; other site 426355015076 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 426355015077 MgtE intracellular N domain; Region: MgtE_N; pfam03448 426355015078 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 426355015079 Divalent cation transporter; Region: MgtE; pfam01769 426355015080 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 426355015081 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426355015082 acyl-activating enzyme (AAE) consensus motif; other site 426355015083 AMP binding site [chemical binding]; other site 426355015084 active site 426355015085 CoA binding site [chemical binding]; other site 426355015086 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426355015087 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426355015088 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355015089 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 426355015090 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 426355015091 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 426355015092 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426355015093 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426355015094 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426355015095 active site 426355015096 catalytic tetrad [active] 426355015097 quinolinate synthetase; Provisional; Region: PRK09375 426355015098 L-aspartate oxidase; Provisional; Region: PRK07512 426355015099 L-aspartate oxidase; Provisional; Region: PRK06175 426355015100 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 426355015101 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 426355015102 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 426355015103 dimerization interface [polypeptide binding]; other site 426355015104 active site 426355015105 K+ potassium transporter; Region: K_trans; cl15781 426355015106 potassium uptake protein; Region: kup; TIGR00794 426355015107 heat shock protein 90; Provisional; Region: PRK05218 426355015108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355015109 ATP binding site [chemical binding]; other site 426355015110 Mg2+ binding site [ion binding]; other site 426355015111 G-X-G motif; other site 426355015112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 426355015113 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 426355015114 OstA-like protein; Region: OstA; pfam03968 426355015115 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 426355015116 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 426355015117 Walker A/P-loop; other site 426355015118 ATP binding site [chemical binding]; other site 426355015119 Q-loop/lid; other site 426355015120 ABC transporter signature motif; other site 426355015121 Walker B; other site 426355015122 D-loop; other site 426355015123 H-loop/switch region; other site 426355015124 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 426355015125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355015126 D-galactonate transporter; Region: 2A0114; TIGR00893 426355015127 putative substrate translocation pore; other site 426355015128 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 426355015129 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355015130 Right handed beta helix region; Region: Beta_helix; pfam13229 426355015131 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 426355015132 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 426355015133 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 426355015134 active site 426355015135 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 426355015136 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 426355015137 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 426355015138 putative trimer interface [polypeptide binding]; other site 426355015139 putative CoA binding site [chemical binding]; other site 426355015140 serine O-acetyltransferase; Region: cysE; TIGR01172 426355015141 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 426355015142 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 426355015143 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426355015144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355015145 S-adenosylmethionine binding site [chemical binding]; other site 426355015146 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 426355015147 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 426355015148 Probable Catalytic site; other site 426355015149 metal-binding site 426355015150 O-Antigen ligase; Region: Wzy_C; pfam04932 426355015151 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 426355015152 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 426355015153 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 426355015154 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 426355015155 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 426355015156 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 426355015157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 426355015158 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 426355015159 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 426355015160 Beta-lactamase; Region: Beta-lactamase; pfam00144 426355015161 Domain of unknown function (DUF427); Region: DUF427; pfam04248 426355015162 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 426355015163 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 426355015164 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 426355015165 Glucokinase; Region: Glucokinase; cl17310 426355015166 glucokinase, proteobacterial type; Region: glk; TIGR00749 426355015167 benzoate transport; Region: 2A0115; TIGR00895 426355015168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355015169 putative substrate translocation pore; other site 426355015170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355015171 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 426355015172 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 426355015173 putative ligand binding site [chemical binding]; other site 426355015174 NAD binding site [chemical binding]; other site 426355015175 dimerization interface [polypeptide binding]; other site 426355015176 catalytic site [active] 426355015177 LysR family transcriptional regulator; Provisional; Region: PRK14997 426355015178 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355015179 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 426355015180 dimerization interface [polypeptide binding]; other site 426355015181 short chain dehydrogenase; Provisional; Region: PRK06500 426355015182 classical (c) SDRs; Region: SDR_c; cd05233 426355015183 NAD(P) binding site [chemical binding]; other site 426355015184 active site 426355015185 short chain dehydrogenase; Provisional; Region: PRK06180 426355015186 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 426355015187 NADP binding site [chemical binding]; other site 426355015188 active site 426355015189 steroid binding site; other site 426355015190 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 426355015191 active site 426355015192 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 426355015193 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 426355015194 multimer interface [polypeptide binding]; other site 426355015195 active site 426355015196 catalytic triad [active] 426355015197 dimer interface [polypeptide binding]; other site 426355015198 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 426355015199 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 426355015200 hypothetical protein; Validated; Region: PRK07581 426355015201 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 426355015202 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 426355015203 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426355015204 Walker A/P-loop; other site 426355015205 ATP binding site [chemical binding]; other site 426355015206 Q-loop/lid; other site 426355015207 ABC transporter signature motif; other site 426355015208 Walker B; other site 426355015209 D-loop; other site 426355015210 H-loop/switch region; other site 426355015211 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 426355015212 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426355015213 Walker A/P-loop; other site 426355015214 ATP binding site [chemical binding]; other site 426355015215 Q-loop/lid; other site 426355015216 ABC transporter signature motif; other site 426355015217 Walker B; other site 426355015218 D-loop; other site 426355015219 H-loop/switch region; other site 426355015220 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426355015221 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426355015222 TM-ABC transporter signature motif; other site 426355015223 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426355015224 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426355015225 TM-ABC transporter signature motif; other site 426355015226 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355015227 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 426355015228 putative ligand binding site [chemical binding]; other site 426355015229 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 426355015230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355015231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355015232 dimer interface [polypeptide binding]; other site 426355015233 phosphorylation site [posttranslational modification] 426355015234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355015235 ATP binding site [chemical binding]; other site 426355015236 Mg2+ binding site [ion binding]; other site 426355015237 G-X-G motif; other site 426355015238 Response regulator receiver domain; Region: Response_reg; pfam00072 426355015239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355015240 active site 426355015241 phosphorylation site [posttranslational modification] 426355015242 intermolecular recognition site; other site 426355015243 dimerization interface [polypeptide binding]; other site 426355015244 Response regulator receiver domain; Region: Response_reg; pfam00072 426355015245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355015246 active site 426355015247 phosphorylation site [posttranslational modification] 426355015248 intermolecular recognition site; other site 426355015249 dimerization interface [polypeptide binding]; other site 426355015250 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426355015251 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355015252 DNA binding residues [nucleotide binding] 426355015253 dimerization interface [polypeptide binding]; other site 426355015254 Protein of unknown function, DUF488; Region: DUF488; pfam04343 426355015255 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 426355015256 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 426355015257 active site 426355015258 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355015259 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426355015260 putative switch regulator; other site 426355015261 non-specific DNA interactions [nucleotide binding]; other site 426355015262 DNA binding site [nucleotide binding] 426355015263 sequence specific DNA binding site [nucleotide binding]; other site 426355015264 putative cAMP binding site [chemical binding]; other site 426355015265 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 426355015266 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 426355015267 Walker A/P-loop; other site 426355015268 ATP binding site [chemical binding]; other site 426355015269 Q-loop/lid; other site 426355015270 ABC transporter signature motif; other site 426355015271 Walker B; other site 426355015272 D-loop; other site 426355015273 H-loop/switch region; other site 426355015274 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 426355015275 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 426355015276 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 426355015277 dimer interface [polypeptide binding]; other site 426355015278 putative PBP binding regions; other site 426355015279 ABC-ATPase subunit interface; other site 426355015280 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 426355015281 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 426355015282 putative metal binding site [ion binding]; other site 426355015283 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426355015284 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 426355015285 active site 426355015286 metal binding site [ion binding]; metal-binding site 426355015287 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 426355015288 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 426355015289 HSP70 interaction site [polypeptide binding]; other site 426355015290 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 426355015291 substrate binding site [polypeptide binding]; other site 426355015292 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 426355015293 dimer interface [polypeptide binding]; other site 426355015294 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 426355015295 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 426355015296 NAD binding site [chemical binding]; other site 426355015297 homotetramer interface [polypeptide binding]; other site 426355015298 homodimer interface [polypeptide binding]; other site 426355015299 substrate binding site [chemical binding]; other site 426355015300 active site 426355015301 Predicted ATPase [General function prediction only]; Region: COG4637 426355015302 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 426355015303 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 426355015304 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426355015305 catalytic core [active] 426355015306 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 426355015307 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 426355015308 acyl-activating enzyme (AAE) consensus motif; other site 426355015309 AMP binding site [chemical binding]; other site 426355015310 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 426355015311 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 426355015312 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 426355015313 putative trimer interface [polypeptide binding]; other site 426355015314 putative CoA binding site [chemical binding]; other site 426355015315 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 426355015316 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355015317 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355015318 active site 426355015319 I-site; other site 426355015320 metal binding site [ion binding]; metal-binding site 426355015321 PAS domain; Region: PAS_9; pfam13426 426355015322 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355015323 putative active site [active] 426355015324 heme pocket [chemical binding]; other site 426355015325 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355015326 PAS domain; Region: PAS_9; pfam13426 426355015327 putative active site [active] 426355015328 heme pocket [chemical binding]; other site 426355015329 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355015330 dimer interface [polypeptide binding]; other site 426355015331 putative CheW interface [polypeptide binding]; other site 426355015332 SlyX; Region: SlyX; pfam04102 426355015333 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426355015334 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 426355015335 tetramerization interface [polypeptide binding]; other site 426355015336 NAD(P) binding site [chemical binding]; other site 426355015337 catalytic residues [active] 426355015338 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 426355015339 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 426355015340 putative active site [active] 426355015341 putative dimer interface [polypeptide binding]; other site 426355015342 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355015343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355015344 active site 426355015345 phosphorylation site [posttranslational modification] 426355015346 intermolecular recognition site; other site 426355015347 dimerization interface [polypeptide binding]; other site 426355015348 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 426355015349 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 426355015350 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 426355015351 tetramer interface [polypeptide binding]; other site 426355015352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355015353 catalytic residue [active] 426355015354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 426355015355 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 426355015356 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 426355015357 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 426355015358 G1 box; other site 426355015359 putative GEF interaction site [polypeptide binding]; other site 426355015360 GTP/Mg2+ binding site [chemical binding]; other site 426355015361 Switch I region; other site 426355015362 G2 box; other site 426355015363 G3 box; other site 426355015364 Switch II region; other site 426355015365 G4 box; other site 426355015366 G5 box; other site 426355015367 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 426355015368 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 426355015369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355015370 active site 426355015371 phosphorylation site [posttranslational modification] 426355015372 intermolecular recognition site; other site 426355015373 dimerization interface [polypeptide binding]; other site 426355015374 Sensors of blue-light using FAD; Region: BLUF; pfam04940 426355015375 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 426355015376 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 426355015377 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 426355015378 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 426355015379 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 426355015380 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913 426355015381 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 426355015382 Rod binding protein; Region: Rod-binding; cl01626 426355015383 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 426355015384 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 426355015385 Class II flagellar assembly regulator; Region: FliX; cl11677 426355015386 HerA helicase [Replication, recombination, and repair]; Region: COG0433 426355015387 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 426355015388 putative chaperone; Provisional; Region: PRK11678 426355015389 nucleotide binding site [chemical binding]; other site 426355015390 putative NEF/HSP70 interaction site [polypeptide binding]; other site 426355015391 SBD interface [polypeptide binding]; other site 426355015392 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 426355015393 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 426355015394 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 426355015395 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 426355015396 TadE-like protein; Region: TadE; pfam07811 426355015397 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 426355015398 TadE-like protein; Region: TadE; pfam07811 426355015399 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 426355015400 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 426355015401 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 426355015402 active site 426355015403 HIGH motif; other site 426355015404 nucleotide binding site [chemical binding]; other site 426355015405 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 426355015406 active site 426355015407 KMSKS motif; other site 426355015408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355015409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355015410 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 426355015411 putative substrate translocation pore; other site 426355015412 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 426355015413 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 426355015414 ligand binding site [chemical binding]; other site 426355015415 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 426355015416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 426355015417 CreA protein; Region: CreA; pfam05981 426355015418 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 426355015419 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 426355015420 active site 426355015421 HIGH motif; other site 426355015422 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 426355015423 KMSKS motif; other site 426355015424 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 426355015425 tRNA binding surface [nucleotide binding]; other site 426355015426 anticodon binding site; other site 426355015427 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 426355015428 active site 426355015429 substrate binding sites [chemical binding]; other site 426355015430 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355015431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355015432 active site 426355015433 phosphorylation site [posttranslational modification] 426355015434 intermolecular recognition site; other site 426355015435 dimerization interface [polypeptide binding]; other site 426355015436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355015437 DNA binding site [nucleotide binding] 426355015438 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 426355015439 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 426355015440 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 426355015441 Walker A motif/ATP binding site; other site 426355015442 Walker B motif; other site 426355015443 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 426355015444 Predicted integral membrane protein [Function unknown]; Region: COG0392 426355015445 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 426355015446 FHIPEP family; Region: FHIPEP; pfam00771 426355015447 Chain length determinant protein; Region: Wzz; cl15801 426355015448 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 426355015449 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 426355015450 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 426355015451 Walker A/P-loop; other site 426355015452 ATP binding site [chemical binding]; other site 426355015453 Q-loop/lid; other site 426355015454 ABC transporter signature motif; other site 426355015455 Walker B; other site 426355015456 D-loop; other site 426355015457 H-loop/switch region; other site 426355015458 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355015459 PAS domain; Region: PAS_9; pfam13426 426355015460 putative active site [active] 426355015461 heme pocket [chemical binding]; other site 426355015462 formyl-coenzyme A transferase; Provisional; Region: PRK05398 426355015463 CoA-transferase family III; Region: CoA_transf_3; pfam02515 426355015464 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 426355015465 HPP family; Region: HPP; pfam04982 426355015466 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 426355015467 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 426355015468 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 426355015469 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 426355015470 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426355015471 PYR/PP interface [polypeptide binding]; other site 426355015472 dimer interface [polypeptide binding]; other site 426355015473 TPP binding site [chemical binding]; other site 426355015474 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426355015475 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 426355015476 TPP-binding site; other site 426355015477 dimer interface [polypeptide binding]; other site 426355015478 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 426355015479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355015480 putative substrate translocation pore; other site 426355015481 Zeta toxin; Region: Zeta_toxin; pfam06414 426355015482 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 426355015483 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 426355015484 homodimer interface [polypeptide binding]; other site 426355015485 substrate-cofactor binding pocket; other site 426355015486 catalytic residue [active] 426355015487 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 426355015488 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426355015489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355015490 Walker A/P-loop; other site 426355015491 ATP binding site [chemical binding]; other site 426355015492 Q-loop/lid; other site 426355015493 ABC transporter signature motif; other site 426355015494 Walker B; other site 426355015495 D-loop; other site 426355015496 H-loop/switch region; other site 426355015497 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 426355015498 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 426355015499 intersubunit interface [polypeptide binding]; other site 426355015500 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 426355015501 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 426355015502 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 426355015503 purine monophosphate binding site [chemical binding]; other site 426355015504 dimer interface [polypeptide binding]; other site 426355015505 putative catalytic residues [active] 426355015506 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 426355015507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355015508 putative substrate translocation pore; other site 426355015509 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 426355015510 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 426355015511 Na binding site [ion binding]; other site 426355015512 Protein of unknown function, DUF485; Region: DUF485; pfam04341 426355015513 acetyl-CoA synthetase; Provisional; Region: PRK00174 426355015514 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 426355015515 active site 426355015516 CoA binding site [chemical binding]; other site 426355015517 acyl-activating enzyme (AAE) consensus motif; other site 426355015518 AMP binding site [chemical binding]; other site 426355015519 acetate binding site [chemical binding]; other site 426355015520 PAS fold; Region: PAS; pfam00989 426355015521 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355015522 putative active site [active] 426355015523 heme pocket [chemical binding]; other site 426355015524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355015525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355015526 dimer interface [polypeptide binding]; other site 426355015527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355015528 ATP binding site [chemical binding]; other site 426355015529 Mg2+ binding site [ion binding]; other site 426355015530 G-X-G motif; other site 426355015531 Phasin protein; Region: Phasin_2; cl11491 426355015532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 426355015533 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 426355015534 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 426355015535 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 426355015536 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 426355015537 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 426355015538 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 426355015539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355015540 Response regulator receiver domain; Region: Response_reg; pfam00072 426355015541 active site 426355015542 phosphorylation site [posttranslational modification] 426355015543 intermolecular recognition site; other site 426355015544 dimerization interface [polypeptide binding]; other site 426355015545 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426355015546 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426355015547 catalytic residue [active] 426355015548 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 426355015549 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 426355015550 motif 1; other site 426355015551 active site 426355015552 motif 2; other site 426355015553 motif 3; other site 426355015554 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 426355015555 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 426355015556 UTRA domain; Region: UTRA; cl17743 426355015557 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426355015558 E3 interaction surface; other site 426355015559 lipoyl attachment site [posttranslational modification]; other site 426355015560 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 426355015561 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 426355015562 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 426355015563 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 426355015564 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 426355015565 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 426355015566 E3 interaction surface; other site 426355015567 lipoyl attachment site [posttranslational modification]; other site 426355015568 e3 binding domain; Region: E3_binding; pfam02817 426355015569 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 426355015570 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 426355015571 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 426355015572 dimer interface [polypeptide binding]; other site 426355015573 TPP-binding site [chemical binding]; other site 426355015574 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 426355015575 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 426355015576 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426355015577 putative DNA binding site [nucleotide binding]; other site 426355015578 putative Zn2+ binding site [ion binding]; other site 426355015579 AsnC family; Region: AsnC_trans_reg; pfam01037 426355015580 TIGR02300 family protein; Region: FYDLN_acid 426355015581 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 426355015582 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 426355015583 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 426355015584 hinge; other site 426355015585 active site 426355015586 cytidylate kinase; Provisional; Region: cmk; PRK00023 426355015587 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 426355015588 CMP-binding site; other site 426355015589 The sites determining sugar specificity; other site 426355015590 PilZ domain; Region: PilZ; cl01260 426355015591 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 426355015592 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 426355015593 active site 426355015594 cosubstrate binding site; other site 426355015595 substrate binding site [chemical binding]; other site 426355015596 catalytic site [active] 426355015597 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 426355015598 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 426355015599 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 426355015600 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 426355015601 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426355015602 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 426355015603 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 426355015604 dimer interface [polypeptide binding]; other site 426355015605 allosteric magnesium binding site [ion binding]; other site 426355015606 active site 426355015607 aspartate-rich active site metal binding site; other site 426355015608 Schiff base residues; other site 426355015609 RDD family; Region: RDD; pfam06271 426355015610 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 426355015611 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 426355015612 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 426355015613 adenylosuccinate lyase; Provisional; Region: PRK07492 426355015614 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 426355015615 tetramer interface [polypeptide binding]; other site 426355015616 active site 426355015617 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 426355015618 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 426355015619 homodimer interface [polypeptide binding]; other site 426355015620 substrate-cofactor binding pocket; other site 426355015621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355015622 catalytic residue [active] 426355015623 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 426355015624 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 426355015625 GDP-binding site [chemical binding]; other site 426355015626 ACT binding site; other site 426355015627 IMP binding site; other site 426355015628 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 426355015629 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 426355015630 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355015631 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426355015632 DNA binding residues [nucleotide binding] 426355015633 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 426355015634 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 426355015635 RNA binding surface [nucleotide binding]; other site 426355015636 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 426355015637 active site 426355015638 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 426355015639 Methyltransferase domain; Region: Methyltransf_23; pfam13489 426355015640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355015641 S-adenosylmethionine binding site [chemical binding]; other site 426355015642 RNA polymerase sigma factor; Provisional; Region: PRK12547 426355015643 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355015644 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426355015645 DNA binding residues [nucleotide binding] 426355015646 PAS domain; Region: PAS_9; pfam13426 426355015647 PAS domain S-box; Region: sensory_box; TIGR00229 426355015648 PAS domain S-box; Region: sensory_box; TIGR00229 426355015649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355015650 putative active site [active] 426355015651 heme pocket [chemical binding]; other site 426355015652 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426355015653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355015654 DNA binding residues [nucleotide binding] 426355015655 dimerization interface [polypeptide binding]; other site 426355015656 CsbD-like; Region: CsbD; pfam05532 426355015657 CsbD-like; Region: CsbD; pfam05532 426355015658 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 426355015659 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 426355015660 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426355015661 Response regulator receiver domain; Region: Response_reg; pfam00072 426355015662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355015663 active site 426355015664 phosphorylation site [posttranslational modification] 426355015665 intermolecular recognition site; other site 426355015666 dimerization interface [polypeptide binding]; other site 426355015667 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 426355015668 cyclase homology domain; Region: CHD; cd07302 426355015669 nucleotidyl binding site; other site 426355015670 metal binding site [ion binding]; metal-binding site 426355015671 dimer interface [polypeptide binding]; other site 426355015672 Response regulator receiver domain; Region: Response_reg; pfam00072 426355015673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355015674 active site 426355015675 phosphorylation site [posttranslational modification] 426355015676 intermolecular recognition site; other site 426355015677 dimerization interface [polypeptide binding]; other site 426355015678 Cache domain; Region: Cache_1; pfam02743 426355015679 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355015680 dimerization interface [polypeptide binding]; other site 426355015681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355015682 dimer interface [polypeptide binding]; other site 426355015683 phosphorylation site [posttranslational modification] 426355015684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355015685 ATP binding site [chemical binding]; other site 426355015686 Mg2+ binding site [ion binding]; other site 426355015687 G-X-G motif; other site 426355015688 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 426355015689 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426355015690 N-terminal plug; other site 426355015691 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 426355015692 ligand-binding site [chemical binding]; other site 426355015693 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 426355015694 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 426355015695 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 426355015696 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 426355015697 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 426355015698 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 426355015699 Phage Tail Collar Domain; Region: Collar; pfam07484 426355015700 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426355015701 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426355015702 catalytic residue [active] 426355015703 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 426355015704 Protein of unknown function (DUF4043); Region: DUF4043; pfam13252 426355015705 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426355015706 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 426355015707 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355015708 dimer interface [polypeptide binding]; other site 426355015709 putative CheW interface [polypeptide binding]; other site 426355015710 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 426355015711 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 426355015712 Zn2+ binding site [ion binding]; other site 426355015713 Mg2+ binding site [ion binding]; other site 426355015714 Phage terminase large subunit; Region: Terminase_3; cl12054 426355015715 Terminase-like family; Region: Terminase_6; pfam03237 426355015716 Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353 426355015717 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426355015718 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 426355015719 catalytic residues [active] 426355015720 catalytic nucleophile [active] 426355015721 Recombinase; Region: Recombinase; pfam07508 426355015722 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 426355015723 CheB methylesterase; Region: CheB_methylest; pfam01339 426355015724 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 426355015725 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 426355015726 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 426355015727 PAS domain; Region: PAS_10; pfam13596 426355015728 YcfA-like protein; Region: YcfA; pfam07927 426355015729 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 426355015730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 426355015731 S-adenosylmethionine binding site [chemical binding]; other site 426355015732 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 426355015733 Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; pfam13876 426355015734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355015735 non-specific DNA binding site [nucleotide binding]; other site 426355015736 salt bridge; other site 426355015737 sequence-specific DNA binding site [nucleotide binding]; other site 426355015738 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355015739 non-specific DNA binding site [nucleotide binding]; other site 426355015740 salt bridge; other site 426355015741 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 426355015742 sequence-specific DNA binding site [nucleotide binding]; other site 426355015743 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 426355015744 Catalytic site [active] 426355015745 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426355015746 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355015747 sequence-specific DNA binding site [nucleotide binding]; other site 426355015748 salt bridge; other site 426355015749 ERF superfamily; Region: ERF; pfam04404 426355015750 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 426355015751 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 426355015752 Active Sites [active] 426355015753 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 426355015754 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 426355015755 Helix-turn-helix domain; Region: HTH_17; pfam12728 426355015756 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 426355015757 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 426355015758 active site 426355015759 Int/Topo IB signature motif; other site 426355015760 Hint domain; Region: Hint_2; pfam13403 426355015761 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355015762 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355015763 metal binding site [ion binding]; metal-binding site 426355015764 active site 426355015765 I-site; other site 426355015766 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355015767 Domain of unknown function DUF87; Region: DUF87; pfam01935 426355015768 AAA-like domain; Region: AAA_10; pfam12846 426355015769 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 426355015770 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 426355015771 homodimer interface [polypeptide binding]; other site 426355015772 substrate-cofactor binding pocket; other site 426355015773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355015774 catalytic residue [active] 426355015775 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 426355015776 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 426355015777 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 426355015778 FAD binding site [chemical binding]; other site 426355015779 substrate binding site [chemical binding]; other site 426355015780 catalytic residues [active] 426355015781 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 426355015782 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 426355015783 Sel1-like repeats; Region: SEL1; smart00671 426355015784 Sel1-like repeats; Region: SEL1; smart00671 426355015785 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 426355015786 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 426355015787 Autoinducer binding domain; Region: Autoind_bind; pfam03472 426355015788 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355015789 dimerization interface [polypeptide binding]; other site 426355015790 DNA binding residues [nucleotide binding] 426355015791 Autoinducer synthetase; Region: Autoind_synth; cl17404 426355015792 isocitrate dehydrogenase; Validated; Region: PRK08299 426355015793 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 426355015794 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 426355015795 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 426355015796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355015797 Walker A/P-loop; other site 426355015798 ATP binding site [chemical binding]; other site 426355015799 Q-loop/lid; other site 426355015800 ABC transporter signature motif; other site 426355015801 Walker B; other site 426355015802 D-loop; other site 426355015803 H-loop/switch region; other site 426355015804 heme exporter protein CcmB; Region: ccmB; TIGR01190 426355015805 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 426355015806 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426355015807 ATP binding site [chemical binding]; other site 426355015808 putative Mg++ binding site [ion binding]; other site 426355015809 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 426355015810 nucleotide binding region [chemical binding]; other site 426355015811 ATP-binding site [chemical binding]; other site 426355015812 Helix-turn-helix domain; Region: HTH_17; pfam12728 426355015813 AAA domain; Region: AAA_25; pfam13481 426355015814 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 426355015815 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 426355015816 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 426355015817 tandem repeat interface [polypeptide binding]; other site 426355015818 oligomer interface [polypeptide binding]; other site 426355015819 active site residues [active] 426355015820 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426355015821 Magnesium ion binding site [ion binding]; other site 426355015822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355015823 non-specific DNA binding site [nucleotide binding]; other site 426355015824 salt bridge; other site 426355015825 sequence-specific DNA binding site [nucleotide binding]; other site 426355015826 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 426355015827 Fic/DOC family; Region: Fic; pfam02661 426355015828 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 426355015829 FIC domain binding interface [polypeptide binding]; other site 426355015830 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426355015831 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 426355015832 catalytic residues [active] 426355015833 catalytic nucleophile [active] 426355015834 Presynaptic Site I dimer interface [polypeptide binding]; other site 426355015835 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 426355015836 Synaptic Flat tetramer interface [polypeptide binding]; other site 426355015837 Synaptic Site I dimer interface [polypeptide binding]; other site 426355015838 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 426355015839 N-acetyl-D-glucosamine binding site [chemical binding]; other site 426355015840 catalytic residue [active] 426355015841 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 426355015842 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 426355015843 active site 426355015844 interdomain interaction site; other site 426355015845 putative metal-binding site [ion binding]; other site 426355015846 nucleotide binding site [chemical binding]; other site 426355015847 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 426355015848 domain I; other site 426355015849 DNA binding groove [nucleotide binding] 426355015850 phosphate binding site [ion binding]; other site 426355015851 domain II; other site 426355015852 domain III; other site 426355015853 nucleotide binding site [chemical binding]; other site 426355015854 catalytic site [active] 426355015855 domain IV; other site 426355015856 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 426355015857 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 426355015858 TrbC/VIRB2 family; Region: TrbC; cl01583 426355015859 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 426355015860 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 426355015861 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 426355015862 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 426355015863 Type IV secretion system proteins; Region: T4SS; pfam07996 426355015864 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 426355015865 VirB8 protein; Region: VirB8; pfam04335 426355015866 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 426355015867 VirB7 interaction site; other site 426355015868 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 426355015869 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 426355015870 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 426355015871 Walker A motif; other site 426355015872 hexamer interface [polypeptide binding]; other site 426355015873 ATP binding site [chemical binding]; other site 426355015874 Walker B motif; other site 426355015875 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426355015876 Walker A motif; other site 426355015877 ATP binding site [chemical binding]; other site 426355015878 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 426355015879 L11 interface [polypeptide binding]; other site 426355015880 putative EF-Tu interaction site [polypeptide binding]; other site 426355015881 putative EF-G interaction site [polypeptide binding]; other site 426355015882 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426355015883 Walker B motif; other site 426355015884 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 426355015885 ligand binding site [chemical binding]; other site 426355015886 conjugal transfer protein TrbM; Provisional; Region: PRK13893 426355015887 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 426355015888 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 426355015889 ParB-like nuclease domain; Region: ParBc; pfam02195 426355015890 KorB domain; Region: KorB; pfam08535 426355015891 KorB C-terminal beta-barrel domain; Region: KorB_C; pfam06613 426355015892 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 426355015893 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426355015894 P-loop; other site 426355015895 Magnesium ion binding site [ion binding]; other site 426355015896 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426355015897 Magnesium ion binding site [ion binding]; other site 426355015898 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 426355015899 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 426355015900 dimer interface [polypeptide binding]; other site 426355015901 ssDNA binding site [nucleotide binding]; other site 426355015902 tetramer (dimer of dimers) interface [polypeptide binding]; other site 426355015903 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 426355015904 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426355015905 dimerization interface [polypeptide binding]; other site 426355015906 putative DNA binding site [nucleotide binding]; other site 426355015907 putative Zn2+ binding site [ion binding]; other site 426355015908 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 426355015909 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 426355015910 NADP binding site [chemical binding]; other site 426355015911 homodimer interface [polypeptide binding]; other site 426355015912 active site 426355015913 substrate binding site [chemical binding]; other site 426355015914 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 426355015915 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 426355015916 putative metal binding site [ion binding]; other site 426355015917 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 426355015918 active site 426355015919 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 426355015920 putative binding surface; other site 426355015921 active site 426355015922 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 426355015923 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 426355015924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355015925 ATP binding site [chemical binding]; other site 426355015926 Mg2+ binding site [ion binding]; other site 426355015927 G-X-G motif; other site 426355015928 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 426355015929 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 426355015930 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426355015931 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426355015932 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355015933 dimer interface [polypeptide binding]; other site 426355015934 putative CheW interface [polypeptide binding]; other site 426355015935 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 426355015936 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 426355015937 C factor cell-cell signaling protein; Provisional; Region: PRK09009 426355015938 NADP binding site [chemical binding]; other site 426355015939 homodimer interface [polypeptide binding]; other site 426355015940 active site 426355015941 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 426355015942 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 426355015943 NAD binding site [chemical binding]; other site 426355015944 putative substrate binding site 2 [chemical binding]; other site 426355015945 putative substrate binding site 1 [chemical binding]; other site 426355015946 active site 426355015947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355015948 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 426355015949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355015950 dimer interface [polypeptide binding]; other site 426355015951 phosphorylation site [posttranslational modification] 426355015952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355015953 ATP binding site [chemical binding]; other site 426355015954 Mg2+ binding site [ion binding]; other site 426355015955 G-X-G motif; other site 426355015956 Response regulator receiver domain; Region: Response_reg; pfam00072 426355015957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355015958 active site 426355015959 phosphorylation site [posttranslational modification] 426355015960 intermolecular recognition site; other site 426355015961 dimerization interface [polypeptide binding]; other site 426355015962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355015963 Response regulator receiver domain; Region: Response_reg; pfam00072 426355015964 active site 426355015965 phosphorylation site [posttranslational modification] 426355015966 intermolecular recognition site; other site 426355015967 dimerization interface [polypeptide binding]; other site 426355015968 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 426355015969 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355015970 heme pocket [chemical binding]; other site 426355015971 putative active site [active] 426355015972 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355015973 putative active site [active] 426355015974 PAS fold; Region: PAS_3; pfam08447 426355015975 heme pocket [chemical binding]; other site 426355015976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355015977 HWE histidine kinase; Region: HWE_HK; smart00911 426355015978 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426355015979 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 426355015980 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 426355015981 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355015982 dimer interface [polypeptide binding]; other site 426355015983 putative CheW interface [polypeptide binding]; other site 426355015984 PAS fold; Region: PAS_7; pfam12860 426355015985 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355015986 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355015987 metal binding site [ion binding]; metal-binding site 426355015988 active site 426355015989 I-site; other site 426355015990 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355015991 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 426355015992 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 426355015993 Cell division protein 48 (CDC48) domain 2; Region: CDC48_2; smart01072 426355015994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355015995 Walker A motif; other site 426355015996 ATP binding site [chemical binding]; other site 426355015997 Walker B motif; other site 426355015998 arginine finger; other site 426355015999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 426355016000 Walker A motif; other site 426355016001 ATP binding site [chemical binding]; other site 426355016002 Walker B motif; other site 426355016003 arginine finger; other site 426355016004 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 426355016005 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 426355016006 active site 426355016007 catalytic tetrad [active] 426355016008 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 426355016009 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355016010 Walker A/P-loop; other site 426355016011 ATP binding site [chemical binding]; other site 426355016012 Q-loop/lid; other site 426355016013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355016014 ABC transporter signature motif; other site 426355016015 Walker B; other site 426355016016 D-loop; other site 426355016017 H-loop/switch region; other site 426355016018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355016019 Walker A/P-loop; other site 426355016020 ATP binding site [chemical binding]; other site 426355016021 Q-loop/lid; other site 426355016022 ABC transporter signature motif; other site 426355016023 Walker B; other site 426355016024 D-loop; other site 426355016025 H-loop/switch region; other site 426355016026 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 426355016027 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 426355016028 potential catalytic triad [active] 426355016029 conserved cys residue [active] 426355016030 allantoate amidohydrolase; Reviewed; Region: PRK09290 426355016031 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 426355016032 active site 426355016033 metal binding site [ion binding]; metal-binding site 426355016034 dimer interface [polypeptide binding]; other site 426355016035 dihydroorotase; Validated; Region: PRK09060 426355016036 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426355016037 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 426355016038 active site 426355016039 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 426355016040 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 426355016041 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426355016042 active site 426355016043 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 426355016044 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 426355016045 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 426355016046 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 426355016047 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 426355016048 active site 426355016049 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426355016050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355016051 DNA-binding site [nucleotide binding]; DNA binding site 426355016052 FCD domain; Region: FCD; pfam07729 426355016053 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355016054 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 426355016055 substrate binding pocket [chemical binding]; other site 426355016056 membrane-bound complex binding site; other site 426355016057 hinge residues; other site 426355016058 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 426355016059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355016060 dimer interface [polypeptide binding]; other site 426355016061 conserved gate region; other site 426355016062 putative PBP binding loops; other site 426355016063 ABC-ATPase subunit interface; other site 426355016064 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 426355016065 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 426355016066 Walker A/P-loop; other site 426355016067 ATP binding site [chemical binding]; other site 426355016068 Q-loop/lid; other site 426355016069 ABC transporter signature motif; other site 426355016070 Walker B; other site 426355016071 D-loop; other site 426355016072 H-loop/switch region; other site 426355016073 allantoate amidohydrolase; Reviewed; Region: PRK12891 426355016074 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 426355016075 active site 426355016076 metal binding site [ion binding]; metal-binding site 426355016077 dimer interface [polypeptide binding]; other site 426355016078 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 426355016079 putative active site [active] 426355016080 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 426355016081 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 426355016082 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 426355016083 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 426355016084 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426355016085 putative metal binding site [ion binding]; other site 426355016086 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 426355016087 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 426355016088 AMP-binding enzyme; Region: AMP-binding; pfam00501 426355016089 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426355016090 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 426355016091 acyl-activating enzyme (AAE) consensus motif; other site 426355016092 acyl-activating enzyme (AAE) consensus motif; other site 426355016093 AMP binding site [chemical binding]; other site 426355016094 active site 426355016095 CoA binding site [chemical binding]; other site 426355016096 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 426355016097 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 426355016098 CoenzymeA binding site [chemical binding]; other site 426355016099 subunit interaction site [polypeptide binding]; other site 426355016100 PHB binding site; other site 426355016101 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 426355016102 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 426355016103 NAD(P) binding site [chemical binding]; other site 426355016104 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426355016105 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426355016106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355016107 dimer interface [polypeptide binding]; other site 426355016108 conserved gate region; other site 426355016109 putative PBP binding loops; other site 426355016110 ABC-ATPase subunit interface; other site 426355016111 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426355016112 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426355016113 Walker A/P-loop; other site 426355016114 ATP binding site [chemical binding]; other site 426355016115 Q-loop/lid; other site 426355016116 ABC transporter signature motif; other site 426355016117 Walker B; other site 426355016118 D-loop; other site 426355016119 H-loop/switch region; other site 426355016120 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426355016121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355016122 DNA-binding site [nucleotide binding]; DNA binding site 426355016123 FCD domain; Region: FCD; pfam07729 426355016124 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 426355016125 MarR family; Region: MarR; pfam01047 426355016126 dihydroorotase; Provisional; Region: PRK09237 426355016127 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426355016128 active site 426355016129 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 426355016130 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426355016131 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426355016132 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355016133 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 426355016134 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355016135 catalytic loop [active] 426355016136 iron binding site [ion binding]; other site 426355016137 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426355016138 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 426355016139 putative hydrophobic ligand binding site [chemical binding]; other site 426355016140 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 426355016141 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 426355016142 ligand binding site [chemical binding]; other site 426355016143 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426355016144 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426355016145 TM-ABC transporter signature motif; other site 426355016146 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426355016147 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426355016148 TM-ABC transporter signature motif; other site 426355016149 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426355016150 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426355016151 Walker A/P-loop; other site 426355016152 ATP binding site [chemical binding]; other site 426355016153 Q-loop/lid; other site 426355016154 ABC transporter signature motif; other site 426355016155 Walker B; other site 426355016156 D-loop; other site 426355016157 H-loop/switch region; other site 426355016158 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426355016159 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426355016160 Walker A/P-loop; other site 426355016161 ATP binding site [chemical binding]; other site 426355016162 Q-loop/lid; other site 426355016163 ABC transporter signature motif; other site 426355016164 Walker B; other site 426355016165 D-loop; other site 426355016166 H-loop/switch region; other site 426355016167 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 426355016168 iron-sulfur cluster [ion binding]; other site 426355016169 [2Fe-2S] cluster binding site [ion binding]; other site 426355016170 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426355016171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355016172 active site 426355016173 phosphorylation site [posttranslational modification] 426355016174 intermolecular recognition site; other site 426355016175 dimerization interface [polypeptide binding]; other site 426355016176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355016177 DNA binding residues [nucleotide binding] 426355016178 dimerization interface [polypeptide binding]; other site 426355016179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355016180 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355016181 dimer interface [polypeptide binding]; other site 426355016182 phosphorylation site [posttranslational modification] 426355016183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355016184 G-X-G motif; other site 426355016185 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355016186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355016187 active site 426355016188 phosphorylation site [posttranslational modification] 426355016189 intermolecular recognition site; other site 426355016190 dimerization interface [polypeptide binding]; other site 426355016191 Predicted membrane protein [Function unknown]; Region: COG4125 426355016192 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 426355016193 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 426355016194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355016195 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355016196 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 426355016197 dimerization interface [polypeptide binding]; other site 426355016198 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 426355016199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355016200 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 426355016201 putative dimerization interface [polypeptide binding]; other site 426355016202 putative substrate binding pocket [chemical binding]; other site 426355016203 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 426355016204 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 426355016205 active site 426355016206 catalytic site [active] 426355016207 tetramer interface [polypeptide binding]; other site 426355016208 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 426355016209 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 426355016210 Na binding site [ion binding]; other site 426355016211 putative substrate binding site [chemical binding]; other site 426355016212 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 426355016213 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 426355016214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355016215 putative substrate translocation pore; other site 426355016216 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 426355016217 active site 426355016218 homotetramer interface [polypeptide binding]; other site 426355016219 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 426355016220 active site 426355016221 homotetramer interface [polypeptide binding]; other site 426355016222 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 426355016223 hypothetical protein; Provisional; Region: PRK07236 426355016224 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 426355016225 Cupin domain; Region: Cupin_2; cl17218 426355016226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426355016227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355016228 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 426355016229 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355016230 catalytic loop [active] 426355016231 iron binding site [ion binding]; other site 426355016232 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426355016233 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426355016234 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 426355016235 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355016236 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355016237 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 426355016238 putative ligand binding site [chemical binding]; other site 426355016239 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426355016240 TM-ABC transporter signature motif; other site 426355016241 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 426355016242 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426355016243 TM-ABC transporter signature motif; other site 426355016244 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426355016245 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426355016246 Walker A/P-loop; other site 426355016247 ATP binding site [chemical binding]; other site 426355016248 Q-loop/lid; other site 426355016249 ABC transporter signature motif; other site 426355016250 Walker B; other site 426355016251 D-loop; other site 426355016252 H-loop/switch region; other site 426355016253 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426355016254 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426355016255 Walker A/P-loop; other site 426355016256 ATP binding site [chemical binding]; other site 426355016257 Q-loop/lid; other site 426355016258 ABC transporter signature motif; other site 426355016259 Walker B; other site 426355016260 D-loop; other site 426355016261 H-loop/switch region; other site 426355016262 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 426355016263 putative hydrophobic ligand binding site [chemical binding]; other site 426355016264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355016265 metabolite-proton symporter; Region: 2A0106; TIGR00883 426355016266 putative substrate translocation pore; other site 426355016267 Predicted transcriptional regulators [Transcription]; Region: COG1733 426355016268 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 426355016269 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 426355016270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355016271 NAD(P) binding site [chemical binding]; other site 426355016272 active site 426355016273 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 426355016274 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 426355016275 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 426355016276 active site 426355016277 non-prolyl cis peptide bond; other site 426355016278 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 426355016279 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 426355016280 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 426355016281 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 426355016282 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355016283 membrane-bound complex binding site; other site 426355016284 hinge residues; other site 426355016285 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 426355016286 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 426355016287 active site 426355016288 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 426355016289 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 426355016290 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 426355016291 Moco binding site; other site 426355016292 metal coordination site [ion binding]; other site 426355016293 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 426355016294 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 426355016295 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426355016296 N-terminal plug; other site 426355016297 ligand-binding site [chemical binding]; other site 426355016298 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 426355016299 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 426355016300 dimerization interface [polypeptide binding]; other site 426355016301 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355016302 dimer interface [polypeptide binding]; other site 426355016303 putative CheW interface [polypeptide binding]; other site 426355016304 Predicted acetyltransferase [General function prediction only]; Region: COG2388 426355016305 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 426355016306 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355016307 heme pocket [chemical binding]; other site 426355016308 putative active site [active] 426355016309 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 426355016310 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 426355016311 oligomeric interface; other site 426355016312 putative active site [active] 426355016313 homodimer interface [polypeptide binding]; other site 426355016314 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 426355016315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355016316 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 426355016317 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 426355016318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355016319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355016320 Epoxide hydrolase N terminus; Region: EHN; pfam06441 426355016321 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426355016322 Major royal jelly protein; Region: MRJP; pfam03022 426355016323 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 426355016324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355016325 Mg2+ binding site [ion binding]; other site 426355016326 G-X-G motif; other site 426355016327 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 426355016328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355016329 active site 426355016330 phosphorylation site [posttranslational modification] 426355016331 intermolecular recognition site; other site 426355016332 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355016333 DNA binding residues [nucleotide binding] 426355016334 dimerization interface [polypeptide binding]; other site 426355016335 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 426355016336 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 426355016337 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 426355016338 hypothetical protein; Provisional; Region: PRK07236 426355016339 hypothetical protein; Provisional; Region: PRK07588 426355016340 Protein of unknown function DUF72; Region: DUF72; pfam01904 426355016341 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 426355016342 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 426355016343 active site 426355016344 metal binding site [ion binding]; metal-binding site 426355016345 DNA topoisomerase; Region: Topoisom_bac; pfam01131 426355016346 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 426355016347 domain I; other site 426355016348 DNA binding groove [nucleotide binding] 426355016349 phosphate binding site [ion binding]; other site 426355016350 domain II; other site 426355016351 domain III; other site 426355016352 nucleotide binding site [chemical binding]; other site 426355016353 catalytic site [active] 426355016354 domain IV; other site 426355016355 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 426355016356 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 426355016357 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 426355016358 TrkA-N domain; Region: TrkA_N; pfam02254 426355016359 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355016360 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 426355016361 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 426355016362 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355016363 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355016364 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 426355016365 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 426355016366 Walker A/P-loop; other site 426355016367 ATP binding site [chemical binding]; other site 426355016368 Q-loop/lid; other site 426355016369 ABC transporter signature motif; other site 426355016370 Walker B; other site 426355016371 D-loop; other site 426355016372 H-loop/switch region; other site 426355016373 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355016374 sequence-specific DNA binding site [nucleotide binding]; other site 426355016375 salt bridge; other site 426355016376 RNA polymerase sigma factor; Provisional; Region: PRK12547 426355016377 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355016378 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426355016379 DNA binding residues [nucleotide binding] 426355016380 Replication protein C N-terminal domain; Region: RP-C; pfam03428 426355016381 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 426355016382 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 426355016383 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 426355016384 DNA binding residues [nucleotide binding] 426355016385 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426355016386 P-loop; other site 426355016387 Magnesium ion binding site [ion binding]; other site 426355016388 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426355016389 Magnesium ion binding site [ion binding]; other site 426355016390 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 426355016391 ParB-like nuclease domain; Region: ParBc; pfam02195 426355016392 Amidohydrolase; Region: Amidohydro_2; pfam04909 426355016393 Uncharacterized conserved protein [Function unknown]; Region: COG3391 426355016394 NHL repeat; Region: NHL; pfam01436 426355016395 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 426355016396 Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372 426355016397 TPP-binding site; other site 426355016398 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426355016399 PYR/PP interface [polypeptide binding]; other site 426355016400 dimer interface [polypeptide binding]; other site 426355016401 TPP binding site [chemical binding]; other site 426355016402 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355016403 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355016404 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 426355016405 putative dimerization interface [polypeptide binding]; other site 426355016406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355016407 D-galactonate transporter; Region: 2A0114; TIGR00893 426355016408 putative substrate translocation pore; other site 426355016409 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 426355016410 NMT1/THI5 like; Region: NMT1; pfam09084 426355016411 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426355016412 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 426355016413 Predicted thioesterase [General function prediction only]; Region: COG5496 426355016414 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 426355016415 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 426355016416 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 426355016417 FMN-binding pocket [chemical binding]; other site 426355016418 flavin binding motif; other site 426355016419 phosphate binding motif [ion binding]; other site 426355016420 beta-alpha-beta structure motif; other site 426355016421 NAD binding pocket [chemical binding]; other site 426355016422 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355016423 catalytic loop [active] 426355016424 iron binding site [ion binding]; other site 426355016425 MOSC domain; Region: MOSC; pfam03473 426355016426 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 426355016427 homotrimer interaction site [polypeptide binding]; other site 426355016428 putative active site [active] 426355016429 shikimate transporter; Provisional; Region: PRK09952 426355016430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355016431 putative substrate translocation pore; other site 426355016432 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426355016433 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355016434 non-specific DNA binding site [nucleotide binding]; other site 426355016435 salt bridge; other site 426355016436 sequence-specific DNA binding site [nucleotide binding]; other site 426355016437 Cupin domain; Region: Cupin_2; pfam07883 426355016438 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 426355016439 AsnC family; Region: AsnC_trans_reg; pfam01037 426355016440 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 426355016441 TAP-like protein; Region: Abhydrolase_4; pfam08386 426355016442 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426355016443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 426355016444 DNA-binding site [nucleotide binding]; DNA binding site 426355016445 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 426355016446 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 426355016447 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 426355016448 NAD(P) binding site [chemical binding]; other site 426355016449 catalytic residues [active] 426355016450 benzoate transport; Region: 2A0115; TIGR00895 426355016451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355016452 putative substrate translocation pore; other site 426355016453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355016454 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 426355016455 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 426355016456 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 426355016457 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 426355016458 Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546 426355016459 dinuclear metal binding motif [ion binding]; other site 426355016460 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426355016461 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 426355016462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355016463 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 426355016464 putative substrate translocation pore; other site 426355016465 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 426355016466 FAD binding domain; Region: FAD_binding_4; pfam01565 426355016467 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 426355016468 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 426355016469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 426355016470 putative substrate translocation pore; other site 426355016471 Transcriptional regulators [Transcription]; Region: GntR; COG1802 426355016472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355016473 DNA-binding site [nucleotide binding]; DNA binding site 426355016474 FCD domain; Region: FCD; pfam07729 426355016475 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 426355016476 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355016477 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426355016478 DNA binding residues [nucleotide binding] 426355016479 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 426355016480 FecR protein; Region: FecR; pfam04773 426355016481 Secretin and TonB N terminus short domain; Region: STN; smart00965 426355016482 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 426355016483 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426355016484 N-terminal plug; other site 426355016485 ligand-binding site [chemical binding]; other site 426355016486 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 426355016487 Lysozyme family protein [General function prediction only]; Region: COG5526 426355016488 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426355016489 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 426355016490 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 426355016491 Cytochrome P450; Region: p450; cl12078 426355016492 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 426355016493 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 426355016494 active site 426355016495 nucleophile elbow; other site 426355016496 Predicted transporter component [General function prediction only]; Region: COG2391 426355016497 Sulphur transport; Region: Sulf_transp; pfam04143 426355016498 Predicted transporter component [General function prediction only]; Region: COG2391 426355016499 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 426355016500 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 426355016501 putative active site [active] 426355016502 putative metal binding site [ion binding]; other site 426355016503 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 426355016504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426355016505 motif II; other site 426355016506 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 426355016507 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 426355016508 dimer interface [polypeptide binding]; other site 426355016509 active site 426355016510 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426355016511 substrate binding site [chemical binding]; other site 426355016512 catalytic residue [active] 426355016513 Transcriptional regulator [Transcription]; Region: LysR; COG0583 426355016514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355016515 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 426355016516 putative effector binding pocket; other site 426355016517 putative dimerization interface [polypeptide binding]; other site 426355016518 enoyl-CoA hydratase; Validated; Region: PRK08788 426355016519 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 426355016520 substrate binding site [chemical binding]; other site 426355016521 oxyanion hole (OAH) forming residues; other site 426355016522 trimer interface [polypeptide binding]; other site 426355016523 PAS fold; Region: PAS_7; pfam12860 426355016524 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355016525 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355016526 metal binding site [ion binding]; metal-binding site 426355016527 active site 426355016528 I-site; other site 426355016529 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355016530 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 426355016531 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 426355016532 DNA-binding site [nucleotide binding]; DNA binding site 426355016533 UTRA domain; Region: UTRA; pfam07702 426355016534 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 426355016535 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 426355016536 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 426355016537 ligand binding site [chemical binding]; other site 426355016538 NAD binding site [chemical binding]; other site 426355016539 dimerization interface [polypeptide binding]; other site 426355016540 catalytic site [active] 426355016541 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 426355016542 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 426355016543 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 426355016544 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 426355016545 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 426355016546 NMT1-like family; Region: NMT1_2; pfam13379 426355016547 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426355016548 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 426355016549 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 426355016550 PYR/PP interface [polypeptide binding]; other site 426355016551 dimer interface [polypeptide binding]; other site 426355016552 TPP binding site [chemical binding]; other site 426355016553 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 426355016554 TPP-binding site; other site 426355016555 dimer interface [polypeptide binding]; other site 426355016556 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 426355016557 L-aspartate oxidase; Provisional; Region: PRK06175 426355016558 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 426355016559 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 426355016560 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 426355016561 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 426355016562 Iron-sulfur protein interface; other site 426355016563 proximal heme binding site [chemical binding]; other site 426355016564 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 426355016565 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 426355016566 NMT1-like family; Region: NMT1_2; pfam13379 426355016567 NMT1/THI5 like; Region: NMT1; pfam09084 426355016568 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 426355016569 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426355016570 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355016571 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355016572 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 426355016573 Protein export membrane protein; Region: SecD_SecF; cl14618 426355016574 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 426355016575 dihydroxy-acid dehydratase; Validated; Region: PRK06131 426355016576 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148 426355016577 putative efflux protein, MATE family; Region: matE; TIGR00797 426355016578 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 426355016579 CoenzymeA binding site [chemical binding]; other site 426355016580 subunit interaction site [polypeptide binding]; other site 426355016581 PHB binding site; other site 426355016582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 426355016583 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 426355016584 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 426355016585 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355016586 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 426355016587 heme-binding site [chemical binding]; other site 426355016588 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 426355016589 RNA/DNA hybrid binding site [nucleotide binding]; other site 426355016590 active site 426355016591 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 426355016592 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 426355016593 phosphate binding site [ion binding]; other site 426355016594 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 426355016595 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 426355016596 ligand binding site [chemical binding]; other site 426355016597 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426355016598 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 426355016599 TM-ABC transporter signature motif; other site 426355016600 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 426355016601 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 426355016602 TM-ABC transporter signature motif; other site 426355016603 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426355016604 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426355016605 Walker A/P-loop; other site 426355016606 ATP binding site [chemical binding]; other site 426355016607 Q-loop/lid; other site 426355016608 ABC transporter signature motif; other site 426355016609 Walker B; other site 426355016610 D-loop; other site 426355016611 H-loop/switch region; other site 426355016612 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 426355016613 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 426355016614 Walker A/P-loop; other site 426355016615 ATP binding site [chemical binding]; other site 426355016616 Q-loop/lid; other site 426355016617 ABC transporter signature motif; other site 426355016618 Walker B; other site 426355016619 D-loop; other site 426355016620 H-loop/switch region; other site 426355016621 methionine sulfoxide reductase A; Provisional; Region: PRK14054 426355016622 B12 binding domain; Region: B12-binding; pfam02310 426355016623 B12 binding site [chemical binding]; other site 426355016624 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 426355016625 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 426355016626 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 426355016627 DNA-binding site [nucleotide binding]; DNA binding site 426355016628 RNA-binding motif; other site 426355016629 Methyltransferase domain; Region: Methyltransf_11; pfam08241 426355016630 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 426355016631 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 426355016632 short chain dehydrogenase; Provisional; Region: PRK06500 426355016633 classical (c) SDRs; Region: SDR_c; cd05233 426355016634 NAD(P) binding site [chemical binding]; other site 426355016635 active site 426355016636 Predicted transcriptional regulators [Transcription]; Region: COG1733 426355016637 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 426355016638 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 426355016639 Predicted membrane protein [Function unknown]; Region: COG4325 426355016640 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 426355016641 Ion channel; Region: Ion_trans_2; pfam07885 426355016642 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 426355016643 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426355016644 GAF domain; Region: GAF; pfam01590 426355016645 PAS domain S-box; Region: sensory_box; TIGR00229 426355016646 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355016647 putative active site [active] 426355016648 heme pocket [chemical binding]; other site 426355016649 response regulator FixJ; Provisional; Region: fixJ; PRK09390 426355016650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355016651 intermolecular recognition site; other site 426355016652 active site 426355016653 dimerization interface [polypeptide binding]; other site 426355016654 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355016655 DNA binding residues [nucleotide binding] 426355016656 dimerization interface [polypeptide binding]; other site 426355016657 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 426355016658 FAD binding domain; Region: FAD_binding_4; pfam01565 426355016659 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 426355016660 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 426355016661 putative transposase OrfB; Reviewed; Region: PHA02517 426355016662 HTH-like domain; Region: HTH_21; pfam13276 426355016663 Integrase core domain; Region: rve; pfam00665 426355016664 Integrase core domain; Region: rve_2; pfam13333 426355016665 Transposase; Region: HTH_Tnp_1; cl17663 426355016666 ParB-like nuclease domain; Region: ParBc; pfam02195 426355016667 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355016668 Domain of unknown function (DUF4202); Region: DUF4202; pfam13875 426355016669 Uncharacterized conserved protein [Function unknown]; Region: COG5489 426355016670 Toprim domain; Region: Toprim_3; pfam13362 426355016671 active site 426355016672 metal binding site [ion binding]; metal-binding site 426355016673 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 426355016674 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 426355016675 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 426355016676 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355016677 non-specific DNA binding site [nucleotide binding]; other site 426355016678 salt bridge; other site 426355016679 sequence-specific DNA binding site [nucleotide binding]; other site 426355016680 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 426355016681 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 426355016682 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 426355016683 putative C-terminal domain interface [polypeptide binding]; other site 426355016684 putative GSH binding site (G-site) [chemical binding]; other site 426355016685 putative dimer interface [polypeptide binding]; other site 426355016686 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 426355016687 N-terminal domain interface [polypeptide binding]; other site 426355016688 dimer interface [polypeptide binding]; other site 426355016689 substrate binding pocket (H-site) [chemical binding]; other site 426355016690 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 426355016691 Protein of unknown function (DUF461); Region: DUF461; pfam04314 426355016692 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 426355016693 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426355016694 N-terminal plug; other site 426355016695 ligand-binding site [chemical binding]; other site 426355016696 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 426355016697 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426355016698 N-terminal plug; other site 426355016699 ligand-binding site [chemical binding]; other site 426355016700 nickel responsive regulator; Provisional; Region: PRK02967 426355016701 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 426355016702 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 426355016703 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355016704 Walker A/P-loop; other site 426355016705 ATP binding site [chemical binding]; other site 426355016706 Q-loop/lid; other site 426355016707 ABC transporter signature motif; other site 426355016708 Walker B; other site 426355016709 D-loop; other site 426355016710 H-loop/switch region; other site 426355016711 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 426355016712 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 426355016713 Walker A/P-loop; other site 426355016714 ATP binding site [chemical binding]; other site 426355016715 Q-loop/lid; other site 426355016716 ABC transporter signature motif; other site 426355016717 Walker B; other site 426355016718 D-loop; other site 426355016719 H-loop/switch region; other site 426355016720 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 426355016721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355016722 dimer interface [polypeptide binding]; other site 426355016723 conserved gate region; other site 426355016724 putative PBP binding loops; other site 426355016725 ABC-ATPase subunit interface; other site 426355016726 nickel transporter permease NikB; Provisional; Region: PRK10352 426355016727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355016728 dimer interface [polypeptide binding]; other site 426355016729 conserved gate region; other site 426355016730 putative PBP binding loops; other site 426355016731 ABC-ATPase subunit interface; other site 426355016732 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 426355016733 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 426355016734 substrate binding site [chemical binding]; other site 426355016735 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 426355016736 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426355016737 N-terminal plug; other site 426355016738 ligand-binding site [chemical binding]; other site 426355016739 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 426355016740 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 426355016741 intersubunit interface [polypeptide binding]; other site 426355016742 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 426355016743 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 426355016744 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 426355016745 ABC-ATPase subunit interface; other site 426355016746 dimer interface [polypeptide binding]; other site 426355016747 putative PBP binding regions; other site 426355016748 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 426355016749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355016750 Walker A/P-loop; other site 426355016751 ATP binding site [chemical binding]; other site 426355016752 Q-loop/lid; other site 426355016753 ABC transporter signature motif; other site 426355016754 Walker B; other site 426355016755 D-loop; other site 426355016756 H-loop/switch region; other site 426355016757 AAA domain; Region: AAA_33; pfam13671 426355016758 AAA domain; Region: AAA_17; pfam13207 426355016759 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 426355016760 active site 426355016761 catalytic residues [active] 426355016762 DNA binding site [nucleotide binding] 426355016763 Int/Topo IB signature motif; other site 426355016764 aromatic amino acid exporter; Provisional; Region: PRK11689 426355016765 EamA-like transporter family; Region: EamA; pfam00892 426355016766 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 426355016767 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355016768 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 426355016769 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 426355016770 N-terminal plug; other site 426355016771 ligand-binding site [chemical binding]; other site 426355016772 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 426355016773 FecR protein; Region: FecR; pfam04773 426355016774 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 426355016775 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 426355016776 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 426355016777 DNA binding residues [nucleotide binding] 426355016778 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 426355016779 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 426355016780 active site 426355016781 catalytic residues [active] 426355016782 DNA binding site [nucleotide binding] 426355016783 Int/Topo IB signature motif; other site 426355016784 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 426355016785 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 426355016786 proposed catalytic triad [active] 426355016787 conserved cys residue [active] 426355016788 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 426355016789 putative heme binding pocket [chemical binding]; other site 426355016790 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 426355016791 putative heme binding pocket [chemical binding]; other site 426355016792 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 426355016793 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 426355016794 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355016795 dimerization interface [polypeptide binding]; other site 426355016796 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355016797 dimer interface [polypeptide binding]; other site 426355016798 putative CheW interface [polypeptide binding]; other site 426355016799 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 426355016800 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426355016801 Walker A motif; other site 426355016802 ATP binding site [chemical binding]; other site 426355016803 Walker B motif; other site 426355016804 Conjugal transfer protein TraD; Region: TraD; pfam06412 426355016805 TraC-like protein; Region: TraC; cl06725 426355016806 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 426355016807 DNA-binding interface [nucleotide binding]; DNA binding site 426355016808 Winged helix-turn helix; Region: HTH_29; pfam13551 426355016809 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 426355016810 HTH-like domain; Region: HTH_21; pfam13276 426355016811 Integrase core domain; Region: rve; pfam00665 426355016812 Integrase core domain; Region: rve_3; pfam13683 426355016813 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 426355016814 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 426355016815 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 426355016816 Walker A/P-loop; other site 426355016817 ATP binding site [chemical binding]; other site 426355016818 Q-loop/lid; other site 426355016819 ABC transporter signature motif; other site 426355016820 Walker B; other site 426355016821 D-loop; other site 426355016822 H-loop/switch region; other site 426355016823 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 426355016824 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 426355016825 active site 426355016826 non-prolyl cis peptide bond; other site 426355016827 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 426355016828 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 426355016829 active site 426355016830 NTP binding site [chemical binding]; other site 426355016831 metal binding triad [ion binding]; metal-binding site 426355016832 antibiotic binding site [chemical binding]; other site 426355016833 Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748 426355016834 Transposase; Region: HTH_Tnp_1; cl17663 426355016835 putative transposase OrfB; Reviewed; Region: PHA02517 426355016836 HTH-like domain; Region: HTH_21; pfam13276 426355016837 Integrase core domain; Region: rve; pfam00665 426355016838 Integrase core domain; Region: rve_2; pfam13333 426355016839 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 426355016840 active site clefts [active] 426355016841 zinc binding site [ion binding]; other site 426355016842 dimer interface [polypeptide binding]; other site 426355016843 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 426355016844 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355016845 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 426355016846 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 426355016847 putative active site [active] 426355016848 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 426355016849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355016850 Walker A/P-loop; other site 426355016851 ATP binding site [chemical binding]; other site 426355016852 Q-loop/lid; other site 426355016853 ABC transporter signature motif; other site 426355016854 Walker B; other site 426355016855 D-loop; other site 426355016856 H-loop/switch region; other site 426355016857 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 426355016858 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355016859 Walker A/P-loop; other site 426355016860 ATP binding site [chemical binding]; other site 426355016861 Q-loop/lid; other site 426355016862 ABC transporter signature motif; other site 426355016863 Walker B; other site 426355016864 D-loop; other site 426355016865 H-loop/switch region; other site 426355016866 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 426355016867 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 426355016868 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 426355016869 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 426355016870 catalytic triad [active] 426355016871 putative active site [active] 426355016872 Autotransporter beta-domain; Region: Autotransporter; pfam03797 426355016873 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 426355016874 Omptin family; Region: Omptin; cl01886 426355016875 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 426355016876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355016877 active site 426355016878 phosphorylation site [posttranslational modification] 426355016879 intermolecular recognition site; other site 426355016880 dimerization interface [polypeptide binding]; other site 426355016881 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 426355016882 DNA binding site [nucleotide binding] 426355016883 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 426355016884 DNA binding site [nucleotide binding] 426355016885 dimer interface [polypeptide binding]; other site 426355016886 active site 426355016887 Int/Topo IB signature motif; other site 426355016888 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 426355016889 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 426355016890 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 426355016891 active site 426355016892 DNA binding site [nucleotide binding] 426355016893 Int/Topo IB signature motif; other site 426355016894 ATP-grasp domain; Region: ATP-grasp_4; cl17255 426355016895 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 426355016896 active site 426355016897 Winged helix-turn helix; Region: HTH_29; pfam13551 426355016898 DDE superfamily endonuclease; Region: DDE_3; pfam13358 426355016899 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 426355016900 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 426355016901 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355016902 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355016903 ligand binding site [chemical binding]; other site 426355016904 flexible hinge region; other site 426355016905 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 426355016906 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 426355016907 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 426355016908 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 426355016909 Ligand Binding Site [chemical binding]; other site 426355016910 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 426355016911 active site 426355016912 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 426355016913 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 426355016914 DNA binding site [nucleotide binding] 426355016915 dimer interface [polypeptide binding]; other site 426355016916 active site 426355016917 Int/Topo IB signature motif; other site 426355016918 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 426355016919 dimer interface [polypeptide binding]; other site 426355016920 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426355016921 ligand binding site [chemical binding]; other site 426355016922 Protein of unknown function (DUF971); Region: DUF971; pfam06155 426355016923 putative oxidoreductase; Provisional; Region: PRK08275 426355016924 L-aspartate oxidase; Provisional; Region: PRK06175 426355016925 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 426355016926 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 426355016927 HEAT repeats; Region: HEAT_2; pfam13646 426355016928 HEAT repeats; Region: HEAT_2; pfam13646 426355016929 HEAT repeats; Region: HEAT_2; pfam13646 426355016930 HEAT repeats; Region: HEAT_2; pfam13646 426355016931 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355016932 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355016933 ligand binding site [chemical binding]; other site 426355016934 flexible hinge region; other site 426355016935 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 426355016936 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 426355016937 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355016938 substrate binding pocket [chemical binding]; other site 426355016939 membrane-bound complex binding site; other site 426355016940 hinge residues; other site 426355016941 NosL; Region: NosL; cl01769 426355016942 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426355016943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355016944 dimer interface [polypeptide binding]; other site 426355016945 conserved gate region; other site 426355016946 putative PBP binding loops; other site 426355016947 ABC-ATPase subunit interface; other site 426355016948 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426355016949 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426355016950 Walker A/P-loop; other site 426355016951 ATP binding site [chemical binding]; other site 426355016952 Q-loop/lid; other site 426355016953 ABC transporter signature motif; other site 426355016954 Walker B; other site 426355016955 D-loop; other site 426355016956 H-loop/switch region; other site 426355016957 Ferredoxin [Energy production and conversion]; Region: COG1146 426355016958 4Fe-4S binding domain; Region: Fer4; pfam00037 426355016959 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 426355016960 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 426355016961 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 426355016962 FAD binding pocket [chemical binding]; other site 426355016963 FAD binding motif [chemical binding]; other site 426355016964 phosphate binding motif [ion binding]; other site 426355016965 beta-alpha-beta structure motif; other site 426355016966 NAD binding pocket [chemical binding]; other site 426355016967 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355016968 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355016969 ligand binding site [chemical binding]; other site 426355016970 flexible hinge region; other site 426355016971 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 426355016972 putative switch regulator; other site 426355016973 non-specific DNA interactions [nucleotide binding]; other site 426355016974 DNA binding site [nucleotide binding] 426355016975 sequence specific DNA binding site [nucleotide binding]; other site 426355016976 putative cAMP binding site [chemical binding]; other site 426355016977 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 426355016978 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 426355016979 metal binding site [ion binding]; metal-binding site 426355016980 dimer interface [polypeptide binding]; other site 426355016981 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 426355016982 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 426355016983 membrane-bound complex binding site; other site 426355016984 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 426355016985 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 426355016986 Walker A/P-loop; other site 426355016987 ATP binding site [chemical binding]; other site 426355016988 Q-loop/lid; other site 426355016989 ABC transporter signature motif; other site 426355016990 Walker B; other site 426355016991 D-loop; other site 426355016992 H-loop/switch region; other site 426355016993 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 426355016994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355016995 putative PBP binding loops; other site 426355016996 dimer interface [polypeptide binding]; other site 426355016997 ABC-ATPase subunit interface; other site 426355016998 amidase; Provisional; Region: PRK07056 426355016999 Amidase; Region: Amidase; cl11426 426355017000 PBP superfamily domain; Region: PBP_like_2; pfam12849 426355017001 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 426355017002 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 426355017003 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 426355017004 Walker A/P-loop; other site 426355017005 ATP binding site [chemical binding]; other site 426355017006 Q-loop/lid; other site 426355017007 ABC transporter signature motif; other site 426355017008 Walker B; other site 426355017009 D-loop; other site 426355017010 H-loop/switch region; other site 426355017011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 426355017012 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 426355017013 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 426355017014 MPT binding site; other site 426355017015 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 426355017016 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 426355017017 dimer interface [polypeptide binding]; other site 426355017018 putative functional site; other site 426355017019 putative MPT binding site; other site 426355017020 PBP superfamily domain; Region: PBP_like; pfam12727 426355017021 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 426355017022 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355017023 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 426355017024 catalytic loop [active] 426355017025 iron binding site [ion binding]; other site 426355017026 4Fe-4S binding domain; Region: Fer4; pfam00037 426355017027 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 426355017028 [4Fe-4S] binding site [ion binding]; other site 426355017029 molybdopterin cofactor binding site; other site 426355017030 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 426355017031 molybdopterin cofactor binding site; other site 426355017032 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 426355017033 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 426355017034 putative dimer interface [polypeptide binding]; other site 426355017035 [2Fe-2S] cluster binding site [ion binding]; other site 426355017036 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 426355017037 SLBB domain; Region: SLBB; pfam10531 426355017038 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 426355017039 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 426355017040 Walker A motif; other site 426355017041 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 426355017042 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 426355017043 dimer interface [polypeptide binding]; other site 426355017044 putative functional site; other site 426355017045 putative MPT binding site; other site 426355017046 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355017047 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355017048 putative active site [active] 426355017049 heme pocket [chemical binding]; other site 426355017050 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 426355017051 dimer interface [polypeptide binding]; other site 426355017052 phosphorylation site [posttranslational modification] 426355017053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355017054 ATP binding site [chemical binding]; other site 426355017055 Mg2+ binding site [ion binding]; other site 426355017056 G-X-G motif; other site 426355017057 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355017058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355017059 active site 426355017060 phosphorylation site [posttranslational modification] 426355017061 intermolecular recognition site; other site 426355017062 dimerization interface [polypeptide binding]; other site 426355017063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355017064 Response regulator receiver domain; Region: Response_reg; pfam00072 426355017065 active site 426355017066 phosphorylation site [posttranslational modification] 426355017067 intermolecular recognition site; other site 426355017068 dimerization interface [polypeptide binding]; other site 426355017069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355017070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355017071 dimer interface [polypeptide binding]; other site 426355017072 phosphorylation site [posttranslational modification] 426355017073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355017074 ATP binding site [chemical binding]; other site 426355017075 Mg2+ binding site [ion binding]; other site 426355017076 G-X-G motif; other site 426355017077 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355017078 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 426355017079 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 426355017080 non-specific DNA interactions [nucleotide binding]; other site 426355017081 DNA binding site [nucleotide binding] 426355017082 sequence specific DNA binding site [nucleotide binding]; other site 426355017083 putative cAMP binding site [chemical binding]; other site 426355017084 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 426355017085 GAF domain; Region: GAF; pfam01590 426355017086 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 426355017087 GAF domain; Region: GAF_2; pfam13185 426355017088 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355017089 PAS domain; Region: PAS_9; pfam13426 426355017090 putative active site [active] 426355017091 heme pocket [chemical binding]; other site 426355017092 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355017093 PAS fold; Region: PAS_3; pfam08447 426355017094 putative active site [active] 426355017095 heme pocket [chemical binding]; other site 426355017096 PAS domain; Region: PAS_9; pfam13426 426355017097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355017098 PAS domain; Region: PAS_9; pfam13426 426355017099 putative active site [active] 426355017100 heme pocket [chemical binding]; other site 426355017101 PAS domain S-box; Region: sensory_box; TIGR00229 426355017102 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355017103 HWE histidine kinase; Region: HWE_HK; smart00911 426355017104 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 426355017105 PAS fold; Region: PAS_4; pfam08448 426355017106 PAS domain; Region: PAS_8; pfam13188 426355017107 PAS fold; Region: PAS_4; pfam08448 426355017108 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355017109 putative active site [active] 426355017110 heme pocket [chemical binding]; other site 426355017111 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355017112 PAS domain; Region: PAS_9; pfam13426 426355017113 putative active site [active] 426355017114 heme pocket [chemical binding]; other site 426355017115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 426355017116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 426355017117 dimer interface [polypeptide binding]; other site 426355017118 phosphorylation site [posttranslational modification] 426355017119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355017120 ATP binding site [chemical binding]; other site 426355017121 Mg2+ binding site [ion binding]; other site 426355017122 G-X-G motif; other site 426355017123 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355017124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355017125 active site 426355017126 phosphorylation site [posttranslational modification] 426355017127 intermolecular recognition site; other site 426355017128 dimerization interface [polypeptide binding]; other site 426355017129 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 426355017130 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 426355017131 homotrimer interaction site [polypeptide binding]; other site 426355017132 putative active site [active] 426355017133 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 426355017134 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 426355017135 putative ligand binding site [chemical binding]; other site 426355017136 UreD urease accessory protein; Region: UreD; pfam01774 426355017137 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 426355017138 urease subunit alpha; Reviewed; Region: ureC; PRK13308 426355017139 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 426355017140 subunit interactions [polypeptide binding]; other site 426355017141 active site 426355017142 flap region; other site 426355017143 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 426355017144 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 426355017145 alpha-gamma subunit interface [polypeptide binding]; other site 426355017146 beta-gamma subunit interface [polypeptide binding]; other site 426355017147 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 426355017148 alpha-beta subunit interface [polypeptide binding]; other site 426355017149 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 426355017150 UreF; Region: UreF; pfam01730 426355017151 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 426355017152 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 426355017153 dimer interface [polypeptide binding]; other site 426355017154 catalytic residues [active] 426355017155 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 426355017156 ABC-2 type transporter; Region: ABC2_membrane; cl17235 426355017157 Cupin; Region: Cupin_6; pfam12852 426355017158 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355017159 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 426355017160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355017161 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 426355017162 active site 426355017163 homotetramer interface [polypeptide binding]; other site 426355017164 Protein of unknown function (DUF989); Region: DUF989; pfam06181 426355017165 Predicted membrane protein [Function unknown]; Region: COG3748 426355017166 Cytochrome c; Region: Cytochrom_C; pfam00034 426355017167 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 426355017168 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 426355017169 active site 426355017170 catalytic site [active] 426355017171 tetramer interface [polypeptide binding]; other site 426355017172 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 426355017173 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 426355017174 transcriptional activator TtdR; Provisional; Region: PRK09801 426355017175 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 426355017176 putative effector binding pocket; other site 426355017177 dimerization interface [polypeptide binding]; other site 426355017178 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 426355017179 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 426355017180 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 426355017181 catalytic loop [active] 426355017182 iron binding site [ion binding]; other site 426355017183 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 426355017184 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426355017185 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355017186 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 426355017187 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 426355017188 xanthine permease; Region: pbuX; TIGR03173 426355017189 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 426355017190 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 426355017191 active site 426355017192 putative substrate binding pocket [chemical binding]; other site 426355017193 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 426355017194 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 426355017195 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 426355017196 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 426355017197 dimer interface [polypeptide binding]; other site 426355017198 active site 426355017199 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 426355017200 substrate binding site [chemical binding]; other site 426355017201 catalytic residue [active] 426355017202 serine racemase; Region: PLN02970 426355017203 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 426355017204 tetramer interface [polypeptide binding]; other site 426355017205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355017206 catalytic residue [active] 426355017207 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 426355017208 homodimer interface [polypeptide binding]; other site 426355017209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 426355017210 catalytic residue [active] 426355017211 Transcriptional regulator [Transcription]; Region: IclR; COG1414 426355017212 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 426355017213 Bacterial transcriptional regulator; Region: IclR; pfam01614 426355017214 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 426355017215 primary metal binding site; other site 426355017216 catalytic residues [active] 426355017217 CHASE domain; Region: CHASE; pfam03924 426355017218 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 426355017219 dimer interface [polypeptide binding]; other site 426355017220 phosphorylation site [posttranslational modification] 426355017221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 426355017222 ATP binding site [chemical binding]; other site 426355017223 Mg2+ binding site [ion binding]; other site 426355017224 G-X-G motif; other site 426355017225 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355017226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355017227 active site 426355017228 phosphorylation site [posttranslational modification] 426355017229 intermolecular recognition site; other site 426355017230 dimerization interface [polypeptide binding]; other site 426355017231 hypothetical protein; Provisional; Region: PRK01254 426355017232 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 426355017233 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 426355017234 Predicted transcriptional regulators [Transcription]; Region: COG1733 426355017235 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 426355017236 dimerization interface [polypeptide binding]; other site 426355017237 putative DNA binding site [nucleotide binding]; other site 426355017238 putative Zn2+ binding site [ion binding]; other site 426355017239 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 426355017240 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 426355017241 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 426355017242 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 426355017243 dimer interface [polypeptide binding]; other site 426355017244 RibD C-terminal domain; Region: RibD_C; cl17279 426355017245 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 426355017246 thiamine pyrophosphate protein; Provisional; Region: PRK08273 426355017247 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 426355017248 PYR/PP interface [polypeptide binding]; other site 426355017249 dimer interface [polypeptide binding]; other site 426355017250 tetramer interface [polypeptide binding]; other site 426355017251 TPP binding site [chemical binding]; other site 426355017252 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 426355017253 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 426355017254 TPP-binding site [chemical binding]; other site 426355017255 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 426355017256 Strictosidine synthase; Region: Str_synth; pfam03088 426355017257 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 426355017258 heme-binding residues [chemical binding]; other site 426355017259 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 426355017260 molybdopterin cofactor binding site; other site 426355017261 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 426355017262 4Fe-4S binding domain; Region: Fer4; cl02805 426355017263 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 426355017264 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 426355017265 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 426355017266 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 426355017267 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 426355017268 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 426355017269 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 426355017270 Cytochrome c; Region: Cytochrom_C; pfam00034 426355017271 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 426355017272 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 426355017273 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 426355017274 Subunit I/III interface [polypeptide binding]; other site 426355017275 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 426355017276 Predicted membrane protein [Function unknown]; Region: COG2323 426355017277 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 426355017278 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 426355017279 Domain of unknown function DUF20; Region: UPF0118; pfam01594 426355017280 Low affinity iron permease; Region: Iron_permease; pfam04120 426355017281 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 426355017282 GAF domain; Region: GAF; pfam01590 426355017283 Phytochrome region; Region: PHY; pfam00360 426355017284 HWE histidine kinase; Region: HWE_HK; pfam07536 426355017285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355017286 Response regulator receiver domain; Region: Response_reg; pfam00072 426355017287 active site 426355017288 phosphorylation site [posttranslational modification] 426355017289 intermolecular recognition site; other site 426355017290 dimerization interface [polypeptide binding]; other site 426355017291 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 426355017292 structural tetrad; other site 426355017293 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 426355017294 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 426355017295 NAD binding site [chemical binding]; other site 426355017296 catalytic Zn binding site [ion binding]; other site 426355017297 structural Zn binding site [ion binding]; other site 426355017298 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 426355017299 putative hydrophobic ligand binding site [chemical binding]; other site 426355017300 PAS fold; Region: PAS; pfam00989 426355017301 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355017302 putative active site [active] 426355017303 heme pocket [chemical binding]; other site 426355017304 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355017305 PAS fold; Region: PAS_3; pfam08447 426355017306 putative active site [active] 426355017307 heme pocket [chemical binding]; other site 426355017308 response regulator FixJ; Provisional; Region: fixJ; PRK09390 426355017309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 426355017310 active site 426355017311 phosphorylation site [posttranslational modification] 426355017312 intermolecular recognition site; other site 426355017313 dimerization interface [polypeptide binding]; other site 426355017314 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355017315 DNA binding residues [nucleotide binding] 426355017316 dimerization interface [polypeptide binding]; other site 426355017317 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 426355017318 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 426355017319 ligand binding site [chemical binding]; other site 426355017320 flexible hinge region; other site 426355017321 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 426355017322 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426355017323 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426355017324 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 426355017325 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 426355017326 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 426355017327 NAD binding site [chemical binding]; other site 426355017328 catalytic Zn binding site [ion binding]; other site 426355017329 structural Zn binding site [ion binding]; other site 426355017330 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 426355017331 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 426355017332 active site 426355017333 DNA binding site [nucleotide binding] 426355017334 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 426355017335 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 426355017336 Catalytic site [active] 426355017337 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 426355017338 Transposase; Region: HTH_Tnp_1; pfam01527 426355017339 putative transposase OrfB; Reviewed; Region: PHA02517 426355017340 HTH-like domain; Region: HTH_21; pfam13276 426355017341 Integrase core domain; Region: rve; pfam00665 426355017342 Integrase core domain; Region: rve_3; pfam13683 426355017343 hypothetical protein; Provisional; Region: PRK13559 426355017344 HWE histidine kinase; Region: HWE_HK; smart00911 426355017345 CheB methylesterase; Region: CheB_methylest; pfam01339 426355017346 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 426355017347 CheB methylesterase; Region: CheB_methylest; pfam01339 426355017348 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 426355017349 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 426355017350 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 426355017351 Protein of unknown function (DUF904); Region: DUF904; pfam06005 426355017352 PAS domain; Region: PAS_10; pfam13596 426355017353 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355017354 PAS fold; Region: PAS_3; pfam08447 426355017355 putative active site [active] 426355017356 heme pocket [chemical binding]; other site 426355017357 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 426355017358 HWE histidine kinase; Region: HWE_HK; smart00911 426355017359 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 426355017360 cheY-homologous receiver domain; Region: REC; smart00448 426355017361 active site 426355017362 phosphorylation site [posttranslational modification] 426355017363 intermolecular recognition site; other site 426355017364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355017365 ABC transporter signature motif; other site 426355017366 Walker B; other site 426355017367 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 426355017368 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 426355017369 DNA-binding site [nucleotide binding]; DNA binding site 426355017370 RNA-binding motif; other site 426355017371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 426355017372 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 426355017373 TIGR02300 family protein; Region: FYDLN_acid 426355017374 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 426355017375 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 426355017376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 426355017377 Walker A/P-loop; other site 426355017378 ATP binding site [chemical binding]; other site 426355017379 Q-loop/lid; other site 426355017380 ABC transporter signature motif; other site 426355017381 Walker B; other site 426355017382 D-loop; other site 426355017383 H-loop/switch region; other site 426355017384 TOBE domain; Region: TOBE_2; pfam08402 426355017385 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 426355017386 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 426355017387 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 426355017388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 426355017389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 426355017390 putative PBP binding loops; other site 426355017391 dimer interface [polypeptide binding]; other site 426355017392 ABC-ATPase subunit interface; other site 426355017393 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 426355017394 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 426355017395 HlyD family secretion protein; Region: HlyD_3; pfam13437 426355017396 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 426355017397 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 426355017398 Walker A/P-loop; other site 426355017399 ATP binding site [chemical binding]; other site 426355017400 Q-loop/lid; other site 426355017401 ABC transporter signature motif; other site 426355017402 Walker B; other site 426355017403 D-loop; other site 426355017404 H-loop/switch region; other site 426355017405 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 426355017406 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 426355017407 active site 426355017408 catalytic residues [active] 426355017409 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 426355017410 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 426355017411 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 426355017412 AAA domain; Region: AAA_30; pfam13604 426355017413 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 426355017414 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355017415 PAS domain; Region: PAS_9; pfam13426 426355017416 putative active site [active] 426355017417 heme pocket [chemical binding]; other site 426355017418 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 426355017419 PAS domain; Region: PAS_9; pfam13426 426355017420 putative active site [active] 426355017421 heme pocket [chemical binding]; other site 426355017422 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 426355017423 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355017424 dimer interface [polypeptide binding]; other site 426355017425 putative CheW interface [polypeptide binding]; other site 426355017426 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 426355017427 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 426355017428 Walker A motif; other site 426355017429 ATP binding site [chemical binding]; other site 426355017430 Walker B motif; other site 426355017431 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 426355017432 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 426355017433 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426355017434 P-loop; other site 426355017435 Magnesium ion binding site [ion binding]; other site 426355017436 DDE superfamily endonuclease; Region: DDE_5; cl17874 426355017437 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 426355017438 catalytic core [active] 426355017439 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426355017440 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 426355017441 catalytic residues [active] 426355017442 catalytic nucleophile [active] 426355017443 Presynaptic Site I dimer interface [polypeptide binding]; other site 426355017444 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 426355017445 Synaptic Flat tetramer interface [polypeptide binding]; other site 426355017446 Synaptic Site I dimer interface [polypeptide binding]; other site 426355017447 DNA binding site [nucleotide binding] 426355017448 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 426355017449 DNA-binding interface [nucleotide binding]; DNA binding site 426355017450 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 426355017451 IHF dimer interface [polypeptide binding]; other site 426355017452 IHF - DNA interface [nucleotide binding]; other site 426355017453 Autoinducer synthetase; Region: Autoind_synth; cl17404 426355017454 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 426355017455 Autoinducer binding domain; Region: Autoind_bind; pfam03472 426355017456 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355017457 DNA binding residues [nucleotide binding] 426355017458 dimerization interface [polypeptide binding]; other site 426355017459 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355017460 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355017461 Predicted transcriptional regulator [Transcription]; Region: COG3888 426355017462 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426355017463 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 426355017464 catalytic residues [active] 426355017465 catalytic nucleophile [active] 426355017466 Presynaptic Site I dimer interface [polypeptide binding]; other site 426355017467 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 426355017468 Synaptic Flat tetramer interface [polypeptide binding]; other site 426355017469 Synaptic Site I dimer interface [polypeptide binding]; other site 426355017470 DNA binding site [nucleotide binding] 426355017471 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 426355017472 DNA-binding interface [nucleotide binding]; DNA binding site 426355017473 Homeodomain-like domain; Region: HTH_23; pfam13384 426355017474 Winged helix-turn helix; Region: HTH_29; pfam13551 426355017475 Homeodomain-like domain; Region: HTH_32; pfam13565 426355017476 DDE superfamily endonuclease; Region: DDE_3; pfam13358 426355017477 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 426355017478 ATP binding site [chemical binding]; other site 426355017479 putative Mg++ binding site [ion binding]; other site 426355017480 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 426355017481 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355017482 non-specific DNA binding site [nucleotide binding]; other site 426355017483 salt bridge; other site 426355017484 sequence-specific DNA binding site [nucleotide binding]; other site 426355017485 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 426355017486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 426355017487 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 426355017488 NAD(P) binding site [chemical binding]; other site 426355017489 active site 426355017490 Acyltransferase family; Region: Acyl_transf_3; pfam01757 426355017491 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 426355017492 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 426355017493 active site 426355017494 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 426355017495 dimer interface [polypeptide binding]; other site 426355017496 catalytic triad [active] 426355017497 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 426355017498 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 426355017499 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 426355017500 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 426355017501 Coenzyme A binding pocket [chemical binding]; other site 426355017502 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426355017503 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 426355017504 catalytic residues [active] 426355017505 catalytic nucleophile [active] 426355017506 Presynaptic Site I dimer interface [polypeptide binding]; other site 426355017507 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 426355017508 Synaptic Flat tetramer interface [polypeptide binding]; other site 426355017509 Synaptic Site I dimer interface [polypeptide binding]; other site 426355017510 DNA binding site [nucleotide binding] 426355017511 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 426355017512 DNA-binding interface [nucleotide binding]; DNA binding site 426355017513 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 426355017514 IHF dimer interface [polypeptide binding]; other site 426355017515 IHF - DNA interface [nucleotide binding]; other site 426355017516 Autoinducer synthetase; Region: Autoind_synth; cl17404 426355017517 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 426355017518 Autoinducer binding domain; Region: Autoind_bind; pfam03472 426355017519 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 426355017520 DNA binding residues [nucleotide binding] 426355017521 dimerization interface [polypeptide binding]; other site 426355017522 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355017523 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355017524 flagellin; Reviewed; Region: PRK12688 426355017525 flagellin; Reviewed; Region: PRK12688 426355017526 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426355017527 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 426355017528 catalytic residues [active] 426355017529 catalytic nucleophile [active] 426355017530 Presynaptic Site I dimer interface [polypeptide binding]; other site 426355017531 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 426355017532 Synaptic Flat tetramer interface [polypeptide binding]; other site 426355017533 Synaptic Site I dimer interface [polypeptide binding]; other site 426355017534 DNA binding site [nucleotide binding] 426355017535 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 426355017536 DNA-binding interface [nucleotide binding]; DNA binding site 426355017537 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 426355017538 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426355017539 P-loop; other site 426355017540 Magnesium ion binding site [ion binding]; other site 426355017541 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 426355017542 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 426355017543 sequence-specific DNA binding site [nucleotide binding]; other site 426355017544 salt bridge; other site 426355017545 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 426355017546 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355017547 Transposase, Mutator family; Region: Transposase_mut; pfam00872 426355017548 MULE transposase domain; Region: MULE; pfam10551 426355017549 putative transposase OrfB; Reviewed; Region: PHA02517 426355017550 HTH-like domain; Region: HTH_21; pfam13276 426355017551 Integrase core domain; Region: rve; pfam00665 426355017552 Integrase core domain; Region: rve_3; pfam13683 426355017553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 426355017554 Transposase; Region: HTH_Tnp_1; cl17663 426355017555 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 426355017556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355017557 aromatic amino acid exporter; Provisional; Region: PRK11689 426355017558 EamA-like transporter family; Region: EamA; pfam00892 426355017559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 426355017560 Coenzyme A binding pocket [chemical binding]; other site 426355017561 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 426355017562 active site residue [active] 426355017563 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 426355017564 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 426355017565 conserved cys residue [active] 426355017566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 426355017567 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 426355017568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 426355017569 dimerization interface [polypeptide binding]; other site 426355017570 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 426355017571 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 426355017572 dimer interface [polypeptide binding]; other site 426355017573 putative CheW interface [polypeptide binding]; other site 426355017574 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 426355017575 EamA-like transporter family; Region: EamA; cl17759 426355017576 EamA-like transporter family; Region: EamA; pfam00892 426355017577 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 426355017578 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 426355017579 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 426355017580 motif II; other site 426355017581 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 426355017582 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355017583 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 426355017584 putative active site [active] 426355017585 putative metal binding residues [ion binding]; other site 426355017586 signature motif; other site 426355017587 putative dimer interface [polypeptide binding]; other site 426355017588 putative phosphate binding site [ion binding]; other site 426355017589 Protein of unknown function (DUF1625); Region: DUF1625; pfam07787 426355017590 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 426355017591 Sel1-like repeats; Region: SEL1; smart00671 426355017592 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 426355017593 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 426355017594 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 426355017595 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 426355017596 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 426355017597 catalytic residues [active] 426355017598 catalytic nucleophile [active] 426355017599 Presynaptic Site I dimer interface [polypeptide binding]; other site 426355017600 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 426355017601 Synaptic Flat tetramer interface [polypeptide binding]; other site 426355017602 Synaptic Site I dimer interface [polypeptide binding]; other site 426355017603 DNA binding site [nucleotide binding] 426355017604 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 426355017605 DNA-binding interface [nucleotide binding]; DNA binding site 426355017606 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 426355017607 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 426355017608 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 426355017609 ParA-like protein; Provisional; Region: PHA02518 426355017610 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 426355017611 P-loop; other site 426355017612 Magnesium ion binding site [ion binding]; other site 426355017613 Replication initiator protein A; Region: RPA; pfam10134 426355017614 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 426355017615 putative transposase OrfB; Reviewed; Region: PHA02517 426355017616 HTH-like domain; Region: HTH_21; pfam13276 426355017617 Integrase core domain; Region: rve; pfam00665 426355017618 Integrase core domain; Region: rve_3; pfam13683 426355017619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 426355017620 Transposase; Region: HTH_Tnp_1; cl17663 426355017621 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 426355017622 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 426355017623 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 426355017624 cytidine deaminase; Provisional; Region: PRK09027 426355017625 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 426355017626 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 426355017627 active site 426355017628 catalytic site [active] 426355017629 substrate binding site [chemical binding]; other site 426355017630 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 426355017631 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355017632 PAS fold; Region: PAS_7; pfam12860 426355017633 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 426355017634 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 426355017635 metal binding site [ion binding]; metal-binding site 426355017636 active site 426355017637 I-site; other site 426355017638 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 426355017639 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 426355017640 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 426355017641 oligomer interface [polypeptide binding]; other site