-- dump date   	20140619_144840
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
395965000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
395965000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
395965000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965000004	Walker A motif; other site
395965000005	ATP binding site [chemical binding]; other site
395965000006	Walker B motif; other site
395965000007	arginine finger; other site
395965000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
395965000009	DnaA box-binding interface [nucleotide binding]; other site
395965000010	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
395965000011	active site
395965000012	putative DNA-binding cleft [nucleotide binding]; other site
395965000013	dimer interface [polypeptide binding]; other site
395965000014	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
395965000015	RuvA N terminal domain; Region: RuvA_N; pfam01330
395965000016	UGMP family protein; Validated; Region: PRK09604
395965000017	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
395965000018	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
395965000019	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
395965000020	active site
395965000021	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
395965000022	ligand binding site [chemical binding]; other site
395965000023	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
395965000024	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
395965000025	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
395965000026	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
395965000027	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
395965000028	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
395965000029	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395965000030	Walker A/P-loop; other site
395965000031	ATP binding site [chemical binding]; other site
395965000032	Q-loop/lid; other site
395965000033	ABC transporter signature motif; other site
395965000034	Walker B; other site
395965000035	D-loop; other site
395965000036	H-loop/switch region; other site
395965000037	alcohol ABC transporter, permease protein; Region: phenyl_ABC_PedC; TIGR03861
395965000038	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
395965000039	Cytochrome c; Region: Cytochrom_C; cl11414
395965000040	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
395965000041	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
395965000042	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395965000043	Walker A/P-loop; other site
395965000044	ATP binding site [chemical binding]; other site
395965000045	Q-loop/lid; other site
395965000046	ABC transporter signature motif; other site
395965000047	Walker B; other site
395965000048	D-loop; other site
395965000049	H-loop/switch region; other site
395965000050	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
395965000051	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395965000052	ATP binding site [chemical binding]; other site
395965000053	putative Mg++ binding site [ion binding]; other site
395965000054	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395965000055	nucleotide binding region [chemical binding]; other site
395965000056	ATP-binding site [chemical binding]; other site
395965000057	RQC domain; Region: RQC; pfam09382
395965000058	HRDC domain; Region: HRDC; pfam00570
395965000059	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
395965000060	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
395965000061	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
395965000062	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
395965000063	flagellar motor protein MotA; Validated; Region: PRK09110
395965000064	Flagellar motor switch protein FliM; Region: FliM; pfam02154
395965000065	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
395965000066	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
395965000067	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
395965000068	FliG C-terminal domain; Region: FliG_C; pfam01706
395965000069	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK13109
395965000070	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
395965000071	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
395965000072	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
395965000073	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
395965000074	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
395965000075	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
395965000076	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
395965000077	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
395965000078	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
395965000079	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
395965000080	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
395965000081	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
395965000082	flagellar basal body P-ring protein; Reviewed; Region: flgI; PRK12789
395965000083	Uncharacterized conserved protein [Function unknown]; Region: COG3334
395965000084	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788
395965000085	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
395965000086	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
395965000087	FliP family; Region: FliP; cl00593
395965000088	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
395965000089	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
395965000090	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
395965000091	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
395965000092	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
395965000093	flagellar motor protein MotB; Validated; Region: motB; PRK05996
395965000094	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
395965000095	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395965000096	ligand binding site [chemical binding]; other site
395965000097	chemotaxis protein; Reviewed; Region: PRK12798
395965000098	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
395965000099	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
395965000100	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395965000101	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395965000102	DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836
395965000103	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
395965000104	active site
395965000105	dimerization interface [polypeptide binding]; other site
395965000106	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395965000107	DNA binding site [nucleotide binding]
395965000108	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
395965000109	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
395965000110	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
395965000111	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
395965000112	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
395965000113	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
395965000114	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
395965000115	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
395965000116	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
395965000117	Flagellar protein FlaF; Region: FlaF; cl11454
395965000118	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
395965000119	flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794
395965000120	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
395965000121	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
395965000122	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
395965000123	flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792
395965000124	FHIPEP family; Region: FHIPEP; pfam00771
395965000125	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
395965000126	Rod binding protein; Region: Rod-binding; pfam10135
395965000127	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965
395965000128	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
395965000129	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395965000130	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
395965000131	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965000132	dimer interface [polypeptide binding]; other site
395965000133	conserved gate region; other site
395965000134	putative PBP binding loops; other site
395965000135	ABC-ATPase subunit interface; other site
395965000136	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
395965000137	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395965000138	Walker A/P-loop; other site
395965000139	ATP binding site [chemical binding]; other site
395965000140	Q-loop/lid; other site
395965000141	ABC transporter signature motif; other site
395965000142	Walker B; other site
395965000143	D-loop; other site
395965000144	H-loop/switch region; other site
395965000145	TOBE domain; Region: TOBE; cl01440
395965000146	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
395965000147	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395965000148	NAD(P) binding site [chemical binding]; other site
395965000149	active site
395965000150	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395965000151	dimerization interface [polypeptide binding]; other site
395965000152	putative DNA binding site [nucleotide binding]; other site
395965000153	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
395965000154	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
395965000155	Walker A/P-loop; other site
395965000156	ATP binding site [chemical binding]; other site
395965000157	Q-loop/lid; other site
395965000158	ABC transporter signature motif; other site
395965000159	Walker B; other site
395965000160	D-loop; other site
395965000161	H-loop/switch region; other site
395965000162	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
395965000163	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
395965000164	Walker A/P-loop; other site
395965000165	ATP binding site [chemical binding]; other site
395965000166	Q-loop/lid; other site
395965000167	ABC transporter signature motif; other site
395965000168	Walker B; other site
395965000169	D-loop; other site
395965000170	H-loop/switch region; other site
395965000171	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
395965000172	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
395965000173	TM-ABC transporter signature motif; other site
395965000174	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
395965000175	TM-ABC transporter signature motif; other site
395965000176	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
395965000177	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
395965000178	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395965000179	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
395965000180	active site
395965000181	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
395965000182	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
395965000183	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
395965000184	Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; cl11535
395965000185	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395965000186	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395965000187	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
395965000188	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
395965000189	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
395965000190	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
395965000191	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
395965000192	trimer interface [polypeptide binding]; other site
395965000193	putative metal binding site [ion binding]; other site
395965000194	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
395965000195	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
395965000196	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
395965000197	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
395965000198	NADP binding site [chemical binding]; other site
395965000199	active site
395965000200	putative substrate binding site [chemical binding]; other site
395965000201	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
395965000202	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
395965000203	NADP-binding site; other site
395965000204	homotetramer interface [polypeptide binding]; other site
395965000205	substrate binding site [chemical binding]; other site
395965000206	homodimer interface [polypeptide binding]; other site
395965000207	active site
395965000208	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
395965000209	Malic enzyme, N-terminal domain; Region: malic; pfam00390
395965000210	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
395965000211	putative NAD(P) binding site [chemical binding]; other site
395965000212	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
395965000213	pantoate--beta-alanine ligase; Region: panC; TIGR00018
395965000214	Pantoate-beta-alanine ligase; Region: PanC; cd00560
395965000215	active site
395965000216	ATP-binding site [chemical binding]; other site
395965000217	pantoate-binding site; other site
395965000218	HXXH motif; other site
395965000219	Acylphosphatase; Region: Acylphosphatase; pfam00708
395965000220	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
395965000221	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
395965000222	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395965000223	RNA binding surface [nucleotide binding]; other site
395965000224	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
395965000225	active site
395965000226	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965000227	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965000228	Domain of unknown function (DUF305); Region: DUF305; pfam03713
395965000229	Vi polysaccharide export protein VexA; Provisional; Region: PRK15175
395965000230	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
395965000231	putative glycosyl transferase; Provisional; Region: PRK10307
395965000232	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
395965000233	Uncharacterized conserved protein [Function unknown]; Region: COG2135
395965000234	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965000235	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965000236	Autoinducer binding domain; Region: Autoind_bind; pfam03472
395965000237	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395965000238	DNA binding residues [nucleotide binding]
395965000239	dimerization interface [polypeptide binding]; other site
395965000240	Autoinducer synthetase; Region: Autoind_synth; cl17404
395965000241	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
395965000242	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
395965000243	NAD(P) binding site [chemical binding]; other site
395965000244	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395965000245	dimerization interface [polypeptide binding]; other site
395965000246	putative DNA binding site [nucleotide binding]; other site
395965000247	putative Zn2+ binding site [ion binding]; other site
395965000248	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
395965000249	ArsC family; Region: ArsC; pfam03960
395965000250	catalytic residues [active]
395965000251	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
395965000252	Sodium Bile acid symporter family; Region: SBF; cl17470
395965000253	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
395965000254	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395965000255	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
395965000256	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
395965000257	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395965000258	RNA binding surface [nucleotide binding]; other site
395965000259	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
395965000260	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
395965000261	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
395965000262	acyl-activating enzyme (AAE) consensus motif; other site
395965000263	acyl-activating enzyme (AAE) consensus motif; other site
395965000264	putative AMP binding site [chemical binding]; other site
395965000265	putative active site [active]
395965000266	putative CoA binding site [chemical binding]; other site
395965000267	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
395965000268	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
395965000269	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
395965000270	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
395965000271	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965000272	putative substrate translocation pore; other site
395965000273	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395965000274	putative DNA binding site [nucleotide binding]; other site
395965000275	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395965000276	putative Zn2+ binding site [ion binding]; other site
395965000277	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395965000278	dimerization interface [polypeptide binding]; other site
395965000279	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
395965000280	Cupin; Region: Cupin_1; smart00835
395965000281	Cupin; Region: Cupin_1; smart00835
395965000282	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965000283	putative substrate translocation pore; other site
395965000284	cyanate hydratase; Validated; Region: PRK02866
395965000285	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
395965000286	oligomer interface [polypeptide binding]; other site
395965000287	active site
395965000288	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
395965000289	hypothetical protein; Provisional; Region: PRK08317
395965000290	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965000291	S-adenosylmethionine binding site [chemical binding]; other site
395965000292	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
395965000293	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395965000294	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395965000295	ABC transporter; Region: ABC_tran_2; pfam12848
395965000296	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395965000297	phosphoglycolate phosphatase; Provisional; Region: PRK13222
395965000298	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395965000299	motif II; other site
395965000300	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
395965000301	tetramer (dimer of dimers) interface [polypeptide binding]; other site
395965000302	active site
395965000303	dimer interface [polypeptide binding]; other site
395965000304	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
395965000305	glutathione reductase; Validated; Region: PRK06116
395965000306	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395965000307	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395965000308	maltose O-acetyltransferase; Provisional; Region: PRK10092
395965000309	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
395965000310	active site
395965000311	substrate binding site [chemical binding]; other site
395965000312	trimer interface [polypeptide binding]; other site
395965000313	CoA binding site [chemical binding]; other site
395965000314	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
395965000315	NAD synthetase; Provisional; Region: PRK13981
395965000316	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
395965000317	multimer interface [polypeptide binding]; other site
395965000318	active site
395965000319	catalytic triad [active]
395965000320	protein interface 1 [polypeptide binding]; other site
395965000321	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
395965000322	homodimer interface [polypeptide binding]; other site
395965000323	NAD binding pocket [chemical binding]; other site
395965000324	ATP binding pocket [chemical binding]; other site
395965000325	Mg binding site [ion binding]; other site
395965000326	active-site loop [active]
395965000327	Beta-lactamase; Region: Beta-lactamase; pfam00144
395965000328	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
395965000329	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
395965000330	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
395965000331	catalytic triad [active]
395965000332	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
395965000333	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
395965000334	conserved cys residue [active]
395965000335	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395965000336	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
395965000337	classical (c) SDRs; Region: SDR_c; cd05233
395965000338	NAD(P) binding site [chemical binding]; other site
395965000339	active site
395965000340	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
395965000341	ligand binding site; other site
395965000342	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
395965000343	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
395965000344	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
395965000345	active site
395965000346	HIGH motif; other site
395965000347	nucleotide binding site [chemical binding]; other site
395965000348	active site
395965000349	KMSKS motif; other site
395965000350	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
395965000351	CreA protein; Region: CreA; pfam05981
395965000352	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
395965000353	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
395965000354	active site
395965000355	HIGH motif; other site
395965000356	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
395965000357	KMSKS motif; other site
395965000358	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
395965000359	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
395965000360	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395965000361	Coenzyme A binding pocket [chemical binding]; other site
395965000362	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
395965000363	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
395965000364	active site
395965000365	catalytic residues [active]
395965000366	metal binding site [ion binding]; metal-binding site
395965000367	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
395965000368	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
395965000369	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
395965000370	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395965000371	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
395965000372	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
395965000373	Walker A/P-loop; other site
395965000374	ATP binding site [chemical binding]; other site
395965000375	Q-loop/lid; other site
395965000376	ABC transporter signature motif; other site
395965000377	Walker B; other site
395965000378	D-loop; other site
395965000379	H-loop/switch region; other site
395965000380	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
395965000381	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
395965000382	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
395965000383	tandem repeat interface [polypeptide binding]; other site
395965000384	oligomer interface [polypeptide binding]; other site
395965000385	active site residues [active]
395965000386	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
395965000387	IHF dimer interface [polypeptide binding]; other site
395965000388	IHF - DNA interface [nucleotide binding]; other site
395965000389	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
395965000390	active site
395965000391	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
395965000392	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
395965000393	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965000394	catalytic residue [active]
395965000395	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
395965000396	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
395965000397	biotin synthase; Region: bioB; TIGR00433
395965000398	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395965000399	FeS/SAM binding site; other site
395965000400	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
395965000401	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
395965000402	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
395965000403	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
395965000404	putative NAD(P) binding site [chemical binding]; other site
395965000405	active site
395965000406	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
395965000407	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
395965000408	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
395965000409	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
395965000410	catalytic site [active]
395965000411	putative active site [active]
395965000412	putative substrate binding site [chemical binding]; other site
395965000413	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
395965000414	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
395965000415	OstA-like protein; Region: OstA; pfam03968
395965000416	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
395965000417	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
395965000418	Walker A/P-loop; other site
395965000419	ATP binding site [chemical binding]; other site
395965000420	Q-loop/lid; other site
395965000421	ABC transporter signature motif; other site
395965000422	Walker B; other site
395965000423	D-loop; other site
395965000424	H-loop/switch region; other site
395965000425	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
395965000426	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
395965000427	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
395965000428	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
395965000429	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
395965000430	active site
395965000431	phosphorylation site [posttranslational modification]
395965000432	glucokinase, proteobacterial type; Region: glk; TIGR00749
395965000433	Glucokinase; Region: Glucokinase; pfam02685
395965000434	fumarate hydratase; Provisional; Region: PRK15389
395965000435	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
395965000436	Fumarase C-terminus; Region: Fumerase_C; pfam05683
395965000437	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
395965000438	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
395965000439	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
395965000440	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
395965000441	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
395965000442	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
395965000443	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
395965000444	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
395965000445	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
395965000446	Protein export membrane protein; Region: SecD_SecF; cl14618
395965000447	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
395965000448	Protein export membrane protein; Region: SecD_SecF; cl14618
395965000449	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395965000450	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965000451	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965000452	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
395965000453	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
395965000454	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
395965000455	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
395965000456	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395965000457	active site
395965000458	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
395965000459	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
395965000460	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
395965000461	dimer interface [polypeptide binding]; other site
395965000462	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965000463	catalytic residue [active]
395965000464	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
395965000465	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
395965000466	homodimer interface [polypeptide binding]; other site
395965000467	substrate-cofactor binding pocket; other site
395965000468	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965000469	catalytic residue [active]
395965000470	Domain of unknown function (DUF955); Region: DUF955; pfam06114
395965000471	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
395965000472	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
395965000473	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
395965000474	Transcriptional regulator; Region: Transcrip_reg; cl00361
395965000475	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
395965000476	active site
395965000477	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
395965000478	TSCPD domain; Region: TSCPD; pfam12637
395965000479	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395965000480	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395965000481	NADH dehydrogenase; Validated; Region: PRK08183
395965000482	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765
395965000483	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
395965000484	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395965000485	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395965000486	protein binding site [polypeptide binding]; other site
395965000487	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395965000488	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395965000489	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965000490	active site
395965000491	phosphorylation site [posttranslational modification]
395965000492	intermolecular recognition site; other site
395965000493	dimerization interface [polypeptide binding]; other site
395965000494	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395965000495	DNA binding site [nucleotide binding]
395965000496	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395965000497	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395965000498	dimerization interface [polypeptide binding]; other site
395965000499	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965000500	dimer interface [polypeptide binding]; other site
395965000501	phosphorylation site [posttranslational modification]
395965000502	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965000503	ATP binding site [chemical binding]; other site
395965000504	Mg2+ binding site [ion binding]; other site
395965000505	G-X-G motif; other site
395965000506	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
395965000507	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
395965000508	metal binding triad; other site
395965000509	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
395965000510	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
395965000511	metal binding triad; other site
395965000512	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395965000513	PAS fold; Region: PAS_3; pfam08447
395965000514	putative active site [active]
395965000515	heme pocket [chemical binding]; other site
395965000516	PAS fold; Region: PAS_7; pfam12860
395965000517	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965000518	dimer interface [polypeptide binding]; other site
395965000519	phosphorylation site [posttranslational modification]
395965000520	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
395965000521	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965000522	ATP binding site [chemical binding]; other site
395965000523	Mg2+ binding site [ion binding]; other site
395965000524	G-X-G motif; other site
395965000525	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
395965000526	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965000527	S-adenosylmethionine binding site [chemical binding]; other site
395965000528	aminopeptidase N; Provisional; Region: pepN; PRK14015
395965000529	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
395965000530	active site
395965000531	Zn binding site [ion binding]; other site
395965000532	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
395965000533	putative hydrophobic ligand binding site [chemical binding]; other site
395965000534	protein interface [polypeptide binding]; other site
395965000535	gate; other site
395965000536	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
395965000537	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
395965000538	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
395965000539	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
395965000540	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
395965000541	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
395965000542	Cation efflux family; Region: Cation_efflux; pfam01545
395965000543	Cation efflux family; Region: Cation_efflux; cl00316
395965000544	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
395965000545	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395965000546	dimer interface [polypeptide binding]; other site
395965000547	active site
395965000548	metal binding site [ion binding]; metal-binding site
395965000549	glutathione binding site [chemical binding]; other site
395965000550	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
395965000551	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
395965000552	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
395965000553	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
395965000554	putative NAD(P) binding site [chemical binding]; other site
395965000555	putative substrate binding site [chemical binding]; other site
395965000556	catalytic Zn binding site [ion binding]; other site
395965000557	structural Zn binding site [ion binding]; other site
395965000558	dimer interface [polypeptide binding]; other site
395965000559	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
395965000560	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395965000561	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
395965000562	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395965000563	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395965000564	catalytic tetrad [active]
395965000565	polyphosphate kinase; Provisional; Region: PRK05443
395965000566	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
395965000567	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
395965000568	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
395965000569	putative domain interface [polypeptide binding]; other site
395965000570	putative active site [active]
395965000571	catalytic site [active]
395965000572	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
395965000573	putative active site [active]
395965000574	putative domain interface [polypeptide binding]; other site
395965000575	catalytic site [active]
395965000576	exopolyphosphatase; Region: exo_poly_only; TIGR03706
395965000577	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
395965000578	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
395965000579	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
395965000580	catalytic site [active]
395965000581	putative active site [active]
395965000582	putative substrate binding site [chemical binding]; other site
395965000583	HRDC domain; Region: HRDC; pfam00570
395965000584	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
395965000585	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
395965000586	dimer interface [polypeptide binding]; other site
395965000587	anticodon binding site; other site
395965000588	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
395965000589	homodimer interface [polypeptide binding]; other site
395965000590	motif 1; other site
395965000591	active site
395965000592	motif 2; other site
395965000593	GAD domain; Region: GAD; pfam02938
395965000594	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395965000595	active site
395965000596	motif 3; other site
395965000597	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395965000598	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
395965000599	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395965000600	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
395965000601	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
395965000602	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
395965000603	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
395965000604	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
395965000605	active site
395965000606	catalytic site [active]
395965000607	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
395965000608	phosphoglucomutase; Region: PLN02307
395965000609	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
395965000610	substrate binding site [chemical binding]; other site
395965000611	dimer interface [polypeptide binding]; other site
395965000612	active site
395965000613	metal binding site [ion binding]; metal-binding site
395965000614	glycogen synthase; Provisional; Region: PRK14099
395965000615	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
395965000616	ADP-binding pocket [chemical binding]; other site
395965000617	homodimer interface [polypeptide binding]; other site
395965000618	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
395965000619	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
395965000620	ligand binding site; other site
395965000621	oligomer interface; other site
395965000622	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
395965000623	dimer interface [polypeptide binding]; other site
395965000624	N-terminal domain interface [polypeptide binding]; other site
395965000625	sulfate 1 binding site; other site
395965000626	glycogen branching enzyme; Provisional; Region: PRK05402
395965000627	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
395965000628	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
395965000629	active site
395965000630	catalytic site [active]
395965000631	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
395965000632	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
395965000633	homodimer interface [polypeptide binding]; other site
395965000634	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
395965000635	active site pocket [active]
395965000636	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395965000637	PAS domain S-box; Region: sensory_box; TIGR00229
395965000638	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395965000639	putative active site [active]
395965000640	heme pocket [chemical binding]; other site
395965000641	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395965000642	HWE histidine kinase; Region: HWE_HK; pfam07536
395965000643	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
395965000644	active site
395965000645	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
395965000646	nudix motif; other site
395965000647	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
395965000648	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
395965000649	DEAD-like helicases superfamily; Region: DEXDc; smart00487
395965000650	ATP binding site [chemical binding]; other site
395965000651	putative Mg++ binding site [ion binding]; other site
395965000652	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395965000653	nucleotide binding region [chemical binding]; other site
395965000654	ATP-binding site [chemical binding]; other site
395965000655	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
395965000656	ornithine decarboxylase; Provisional; Region: PRK13578
395965000657	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395965000658	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395965000659	catalytic residue [active]
395965000660	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
395965000661	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
395965000662	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395965000663	Coenzyme A binding pocket [chemical binding]; other site
395965000664	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
395965000665	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
395965000666	active site
395965000667	catalytic site [active]
395965000668	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
395965000669	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395965000670	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
395965000671	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
395965000672	dimerization interface [polypeptide binding]; other site
395965000673	NAD binding site [chemical binding]; other site
395965000674	ligand binding site [chemical binding]; other site
395965000675	catalytic site [active]
395965000676	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
395965000677	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395965000678	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
395965000679	multidrug resistance protein MdtN; Provisional; Region: PRK10476
395965000680	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965000681	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
395965000682	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
395965000683	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
395965000684	XdhC Rossmann domain; Region: XdhC_C; pfam13478
395965000685	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
395965000686	MG2 domain; Region: A2M_N; pfam01835
395965000687	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
395965000688	Alpha-2-macroglobulin family; Region: A2M; pfam00207
395965000689	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
395965000690	Transglycosylase; Region: Transgly; pfam00912
395965000691	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
395965000692	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
395965000693	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
395965000694	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395965000695	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
395965000696	Novel bacterial esterase 713 that cleaves esters on halogenated cyclic compounds; Region: Esterase_713; cd12807
395965000697	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395965000698	catalytic site [active]
395965000699	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395965000700	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
395965000701	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
395965000702	ATP binding site [chemical binding]; other site
395965000703	substrate interface [chemical binding]; other site
395965000704	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
395965000705	dimerization domain swap beta strand [polypeptide binding]; other site
395965000706	regulatory protein interface [polypeptide binding]; other site
395965000707	active site
395965000708	regulatory phosphorylation site [posttranslational modification]; other site
395965000709	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
395965000710	active pocket/dimerization site; other site
395965000711	active site
395965000712	phosphorylation site [posttranslational modification]
395965000713	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
395965000714	Hpr binding site; other site
395965000715	active site
395965000716	homohexamer subunit interaction site [polypeptide binding]; other site
395965000717	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
395965000718	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
395965000719	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395965000720	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395965000721	dimerization interface [polypeptide binding]; other site
395965000722	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965000723	dimer interface [polypeptide binding]; other site
395965000724	phosphorylation site [posttranslational modification]
395965000725	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965000726	ATP binding site [chemical binding]; other site
395965000727	Mg2+ binding site [ion binding]; other site
395965000728	G-X-G motif; other site
395965000729	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395965000730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965000731	active site
395965000732	phosphorylation site [posttranslational modification]
395965000733	intermolecular recognition site; other site
395965000734	dimerization interface [polypeptide binding]; other site
395965000735	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395965000736	DNA binding site [nucleotide binding]
395965000737	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
395965000738	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
395965000739	molybdenum-pterin binding domain; Region: Mop; TIGR00638
395965000740	TOBE domain; Region: TOBE; cl01440
395965000741	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395965000742	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965000743	S-adenosylmethionine binding site [chemical binding]; other site
395965000744	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
395965000745	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395965000746	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
395965000747	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395965000748	ATP binding site [chemical binding]; other site
395965000749	putative Mg++ binding site [ion binding]; other site
395965000750	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395965000751	nucleotide binding region [chemical binding]; other site
395965000752	ATP-binding site [chemical binding]; other site
395965000753	DEAD/H associated; Region: DEAD_assoc; pfam08494
395965000754	metallophosphoesterase, DNA ligase-associated; Region: P_estr_lig_assc; TIGR04123
395965000755	active site
395965000756	metal binding site [ion binding]; metal-binding site
395965000757	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395965000758	Sel1-like repeats; Region: SEL1; smart00671
395965000759	Sel1-like repeats; Region: SEL1; smart00671
395965000760	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
395965000761	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
395965000762	DNA binding residues [nucleotide binding]
395965000763	putative dimer interface [polypeptide binding]; other site
395965000764	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
395965000765	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
395965000766	RNase E interface [polypeptide binding]; other site
395965000767	trimer interface [polypeptide binding]; other site
395965000768	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
395965000769	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
395965000770	RNase E interface [polypeptide binding]; other site
395965000771	trimer interface [polypeptide binding]; other site
395965000772	active site
395965000773	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
395965000774	putative nucleic acid binding region [nucleotide binding]; other site
395965000775	G-X-X-G motif; other site
395965000776	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
395965000777	RNA binding site [nucleotide binding]; other site
395965000778	domain interface; other site
395965000779	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
395965000780	16S/18S rRNA binding site [nucleotide binding]; other site
395965000781	S13e-L30e interaction site [polypeptide binding]; other site
395965000782	25S rRNA binding site [nucleotide binding]; other site
395965000783	EF-hand domain pair; Region: EF_hand_5; pfam13499
395965000784	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
395965000785	Ca2+ binding site [ion binding]; other site
395965000786	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
395965000787	Ligand Binding Site [chemical binding]; other site
395965000788	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
395965000789	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
395965000790	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
395965000791	putative NADH binding site [chemical binding]; other site
395965000792	putative active site [active]
395965000793	nudix motif; other site
395965000794	putative metal binding site [ion binding]; other site
395965000795	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
395965000796	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965000797	Walker A motif; other site
395965000798	ATP binding site [chemical binding]; other site
395965000799	Walker B motif; other site
395965000800	arginine finger; other site
395965000801	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
395965000802	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
395965000803	hypothetical protein; Validated; Region: PRK00153
395965000804	recombination protein RecR; Reviewed; Region: recR; PRK00076
395965000805	RecR protein; Region: RecR; pfam02132
395965000806	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
395965000807	putative active site [active]
395965000808	putative metal-binding site [ion binding]; other site
395965000809	tetramer interface [polypeptide binding]; other site
395965000810	EamA-like transporter family; Region: EamA; pfam00892
395965000811	EamA-like transporter family; Region: EamA; pfam00892
395965000812	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
395965000813	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395965000814	RmuC family; Region: RmuC; pfam02646
395965000815	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
395965000816	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
395965000817	Bacitracin resistance protein BacA; Region: BacA; pfam02673
395965000818	fumarate hydratase; Reviewed; Region: fumC; PRK00485
395965000819	Class II fumarases; Region: Fumarase_classII; cd01362
395965000820	active site
395965000821	tetramer interface [polypeptide binding]; other site
395965000822	RNA polymerase sigma factor; Provisional; Region: PRK12540
395965000823	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395965000824	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395965000825	DNA binding residues [nucleotide binding]
395965000826	Raspberry bushy dwarf virus coat protein; Region: RBDV_coat; pfam06593
395965000827	two-component response regulator; Provisional; Region: PRK09191
395965000828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965000829	active site
395965000830	phosphorylation site [posttranslational modification]
395965000831	intermolecular recognition site; other site
395965000832	dimerization interface [polypeptide binding]; other site
395965000833	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
395965000834	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
395965000835	dimerization interface [polypeptide binding]; other site
395965000836	metal binding site [ion binding]; metal-binding site
395965000837	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
395965000838	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
395965000839	putative ligand binding site [chemical binding]; other site
395965000840	Predicted methyltransferases [General function prediction only]; Region: COG0313
395965000841	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
395965000842	putative SAM binding site [chemical binding]; other site
395965000843	putative homodimer interface [polypeptide binding]; other site
395965000844	hypothetical protein; Provisional; Region: PRK14679
395965000845	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
395965000846	quinolinate synthetase; Provisional; Region: PRK09375
395965000847	L-aspartate oxidase; Provisional; Region: PRK07512
395965000848	L-aspartate oxidase; Provisional; Region: PRK06175
395965000849	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
395965000850	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
395965000851	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
395965000852	dimerization interface [polypeptide binding]; other site
395965000853	active site
395965000854	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
395965000855	active site residue [active]
395965000856	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
395965000857	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
395965000858	Chromate transporter; Region: Chromate_transp; pfam02417
395965000859	Predicted membrane protein [Function unknown]; Region: COG2259
395965000860	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
395965000861	hypothetical protein; Provisional; Region: PRK05409
395965000862	Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366
395965000863	RNA polymerase sigma factor; Provisional; Region: PRK12512
395965000864	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395965000865	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
395965000866	DNA binding residues [nucleotide binding]
395965000867	Protein of unknown function (DUF1109); Region: DUF1109; cl02071
395965000868	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
395965000869	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
395965000870	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
395965000871	acyl-activating enzyme (AAE) consensus motif; other site
395965000872	putative AMP binding site [chemical binding]; other site
395965000873	putative active site [active]
395965000874	putative CoA binding site [chemical binding]; other site
395965000875	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
395965000876	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
395965000877	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
395965000878	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
395965000879	Cl binding site [ion binding]; other site
395965000880	oligomer interface [polypeptide binding]; other site
395965000881	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
395965000882	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
395965000883	active site
395965000884	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395965000885	Sel1-like repeats; Region: SEL1; smart00671
395965000886	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
395965000887	thiamine phosphate binding site [chemical binding]; other site
395965000888	active site
395965000889	pyrophosphate binding site [ion binding]; other site
395965000890	preprotein translocase subunit SecB; Validated; Region: PRK05751
395965000891	SecA binding site; other site
395965000892	Preprotein binding site; other site
395965000893	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
395965000894	active site
395965000895	NTP binding site [chemical binding]; other site
395965000896	metal binding triad [ion binding]; metal-binding site
395965000897	antibiotic binding site [chemical binding]; other site
395965000898	Protein of unknown function DUF86; Region: DUF86; cl01031
395965000899	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
395965000900	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
395965000901	metal ion-dependent adhesion site (MIDAS); other site
395965000902	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
395965000903	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
395965000904	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
395965000905	DnaJ domain; Region: DnaJ; pfam00226
395965000906	HSP70 interaction site [polypeptide binding]; other site
395965000907	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
395965000908	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
395965000909	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965000910	active site
395965000911	phosphorylation site [posttranslational modification]
395965000912	intermolecular recognition site; other site
395965000913	dimerization interface [polypeptide binding]; other site
395965000914	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
395965000915	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395965000916	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965000917	dimer interface [polypeptide binding]; other site
395965000918	phosphorylation site [posttranslational modification]
395965000919	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965000920	ATP binding site [chemical binding]; other site
395965000921	Mg2+ binding site [ion binding]; other site
395965000922	G-X-G motif; other site
395965000923	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
395965000924	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
395965000925	Protein of unknown function DUF45; Region: DUF45; pfam01863
395965000926	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
395965000927	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
395965000928	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
395965000929	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
395965000930	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
395965000931	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
395965000932	O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080
395965000933	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
395965000934	homodimer interface [polypeptide binding]; other site
395965000935	substrate-cofactor binding pocket; other site
395965000936	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965000937	catalytic residue [active]
395965000938	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
395965000939	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
395965000940	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
395965000941	putative catalytic site [active]
395965000942	putative phosphate binding site [ion binding]; other site
395965000943	active site
395965000944	metal binding site A [ion binding]; metal-binding site
395965000945	DNA binding site [nucleotide binding]
395965000946	putative AP binding site [nucleotide binding]; other site
395965000947	putative metal binding site B [ion binding]; other site
395965000948	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395965000949	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395965000950	ligand binding site [chemical binding]; other site
395965000951	flexible hinge region; other site
395965000952	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395965000953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965000954	active site
395965000955	phosphorylation site [posttranslational modification]
395965000956	intermolecular recognition site; other site
395965000957	dimerization interface [polypeptide binding]; other site
395965000958	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395965000959	DNA binding site [nucleotide binding]
395965000960	Helix-turn-helix domain; Region: HTH_17; pfam12728
395965000961	PBP superfamily domain; Region: PBP_like; pfam12727
395965000962	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
395965000963	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
395965000964	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395965000965	catalytic residue [active]
395965000966	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
395965000967	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
395965000968	HIGH motif; other site
395965000969	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
395965000970	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
395965000971	active site
395965000972	KMSKS motif; other site
395965000973	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
395965000974	tRNA binding surface [nucleotide binding]; other site
395965000975	Lipopolysaccharide-assembly; Region: LptE; cl01125
395965000976	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
395965000977	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
395965000978	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
395965000979	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
395965000980	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
395965000981	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
395965000982	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
395965000983	beta subunit interaction interface [polypeptide binding]; other site
395965000984	Walker A motif; other site
395965000985	ATP binding site [chemical binding]; other site
395965000986	Walker B motif; other site
395965000987	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
395965000988	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
395965000989	core domain interface [polypeptide binding]; other site
395965000990	delta subunit interface [polypeptide binding]; other site
395965000991	epsilon subunit interface [polypeptide binding]; other site
395965000992	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
395965000993	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
395965000994	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
395965000995	alpha subunit interaction interface [polypeptide binding]; other site
395965000996	Walker A motif; other site
395965000997	ATP binding site [chemical binding]; other site
395965000998	Walker B motif; other site
395965000999	inhibitor binding site; inhibition site
395965001000	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
395965001001	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
395965001002	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
395965001003	gamma subunit interface [polypeptide binding]; other site
395965001004	epsilon subunit interface [polypeptide binding]; other site
395965001005	LBP interface [polypeptide binding]; other site
395965001006	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
395965001007	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
395965001008	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395965001009	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395965001010	catalytic loop [active]
395965001011	iron binding site [ion binding]; other site
395965001012	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395965001013	cyclase homology domain; Region: CHD; cd07302
395965001014	nucleotidyl binding site; other site
395965001015	metal binding site [ion binding]; metal-binding site
395965001016	dimer interface [polypeptide binding]; other site
395965001017	ABC transporter ATPase component; Reviewed; Region: PRK11147
395965001018	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395965001019	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395965001020	Cation efflux family; Region: Cation_efflux; cl00316
395965001021	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
395965001022	active site clefts [active]
395965001023	zinc binding site [ion binding]; other site
395965001024	dimer interface [polypeptide binding]; other site
395965001025	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
395965001026	FOG: CBS domain [General function prediction only]; Region: COG0517
395965001027	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
395965001028	nucleophile elbow; other site
395965001029	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
395965001030	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
395965001031	GTP cyclohydrolase I; Provisional; Region: PLN03044
395965001032	active site
395965001033	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
395965001034	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
395965001035	trimerization site [polypeptide binding]; other site
395965001036	active site
395965001037	MltA-interacting protein MipA; Region: MipA; cl01504
395965001038	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
395965001039	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
395965001040	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
395965001041	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
395965001042	Chain length determinant protein; Region: Wzz; cl15801
395965001043	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395965001044	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
395965001045	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
395965001046	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
395965001047	hypothetical protein; Validated; Region: PRK09104
395965001048	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
395965001049	metal binding site [ion binding]; metal-binding site
395965001050	putative dimer interface [polypeptide binding]; other site
395965001051	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965001052	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965001053	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
395965001054	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
395965001055	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
395965001056	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
395965001057	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
395965001058	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
395965001059	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
395965001060	Ligand binding site; other site
395965001061	Putative Catalytic site; other site
395965001062	DXD motif; other site
395965001063	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
395965001064	putative active site [active]
395965001065	YdjC motif; other site
395965001066	Mg binding site [ion binding]; other site
395965001067	putative homodimer interface [polypeptide binding]; other site
395965001068	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395965001069	NAD(P) binding site [chemical binding]; other site
395965001070	active site
395965001071	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
395965001072	Ferritin-like domain; Region: Ferritin; pfam00210
395965001073	dimanganese center [ion binding]; other site
395965001074	DNA photolyase; Region: DNA_photolyase; pfam00875
395965001075	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
395965001076	GMP synthase; Reviewed; Region: guaA; PRK00074
395965001077	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
395965001078	AMP/PPi binding site [chemical binding]; other site
395965001079	candidate oxyanion hole; other site
395965001080	catalytic triad [active]
395965001081	potential glutamine specificity residues [chemical binding]; other site
395965001082	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
395965001083	ATP Binding subdomain [chemical binding]; other site
395965001084	Ligand Binding sites [chemical binding]; other site
395965001085	Dimerization subdomain; other site
395965001086	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
395965001087	classical (c) SDRs; Region: SDR_c; cd05233
395965001088	NAD(P) binding site [chemical binding]; other site
395965001089	active site
395965001090	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
395965001091	Prostaglandin dehydrogenases; Region: PGDH; cd05288
395965001092	NAD(P) binding site [chemical binding]; other site
395965001093	substrate binding site [chemical binding]; other site
395965001094	dimer interface [polypeptide binding]; other site
395965001095	Predicted transcriptional regulators [Transcription]; Region: COG1733
395965001096	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395965001097	short chain dehydrogenase; Provisional; Region: PRK06500
395965001098	classical (c) SDRs; Region: SDR_c; cd05233
395965001099	NAD(P) binding site [chemical binding]; other site
395965001100	active site
395965001101	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395965001102	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965001103	LysR substrate binding domain; Region: LysR_substrate; pfam03466
395965001104	dimerization interface [polypeptide binding]; other site
395965001105	hypothetical protein; Provisional; Region: PRK07588
395965001106	hypothetical protein; Provisional; Region: PRK07236
395965001107	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965001108	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965001109	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
395965001110	RNA polymerase sigma factor; Provisional; Region: PRK11924
395965001111	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395965001112	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395965001113	DNA binding residues [nucleotide binding]
395965001114	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
395965001115	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
395965001116	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
395965001117	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395965001118	active site
395965001119	metal binding site [ion binding]; metal-binding site
395965001120	pyridoxamine kinase; Validated; Region: PRK05756
395965001121	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
395965001122	dimer interface [polypeptide binding]; other site
395965001123	pyridoxal binding site [chemical binding]; other site
395965001124	ATP binding site [chemical binding]; other site
395965001125	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
395965001126	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
395965001127	benzoate transport; Region: 2A0115; TIGR00895
395965001128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965001129	putative substrate translocation pore; other site
395965001130	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965001131	glutamate racemase; Provisional; Region: PRK00865
395965001132	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
395965001133	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395965001134	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
395965001135	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
395965001136	generic binding surface II; other site
395965001137	generic binding surface I; other site
395965001138	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
395965001139	Anti-sigma-K factor rskA; Region: RskA; pfam10099
395965001140	RNA polymerase sigma factor; Provisional; Region: PRK12514
395965001141	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395965001142	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395965001143	DNA binding residues [nucleotide binding]
395965001144	putative cation:proton antiport protein; Provisional; Region: PRK10669
395965001145	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
395965001146	TrkA-N domain; Region: TrkA_N; pfam02254
395965001147	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
395965001148	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395965001149	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965001150	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
395965001151	dimerization interface [polypeptide binding]; other site
395965001152	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
395965001153	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
395965001154	Putative glucoamylase; Region: Glycoamylase; pfam10091
395965001155	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
395965001156	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
395965001157	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
395965001158	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
395965001159	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
395965001160	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
395965001161	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395965001162	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
395965001163	C-terminal domain interface [polypeptide binding]; other site
395965001164	GSH binding site (G-site) [chemical binding]; other site
395965001165	dimer interface [polypeptide binding]; other site
395965001166	dimer interface [polypeptide binding]; other site
395965001167	substrate binding pocket (H-site) [chemical binding]; other site
395965001168	Glutathione S-transferase, C-terminal domain; Region: GST_C_2; pfam13410
395965001169	N-terminal domain interface [polypeptide binding]; other site
395965001170	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395965001171	Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269
395965001172	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
395965001173	classical (c) SDRs; Region: SDR_c; cd05233
395965001174	NAD(P) binding site [chemical binding]; other site
395965001175	active site
395965001176	amidophosphoribosyltransferase; Provisional; Region: PRK09123
395965001177	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
395965001178	active site
395965001179	tetramer interface [polypeptide binding]; other site
395965001180	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395965001181	active site
395965001182	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
395965001183	Colicin V production protein; Region: Colicin_V; pfam02674
395965001184	DNA repair protein RadA; Provisional; Region: PRK11823
395965001185	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395965001186	Walker A motif; other site
395965001187	ATP binding site [chemical binding]; other site
395965001188	Walker B motif; other site
395965001189	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
395965001190	replicative DNA helicase; Provisional; Region: PRK09165
395965001191	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
395965001192	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
395965001193	Walker A motif; other site
395965001194	ATP binding site [chemical binding]; other site
395965001195	Walker B motif; other site
395965001196	DNA binding loops [nucleotide binding]
395965001197	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
395965001198	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395965001199	Protein of unknown function, DUF606; Region: DUF606; pfam04657
395965001200	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
395965001201	dimer interface [polypeptide binding]; other site
395965001202	allosteric magnesium binding site [ion binding]; other site
395965001203	active site
395965001204	aspartate-rich active site metal binding site; other site
395965001205	Schiff base residues; other site
395965001206	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
395965001207	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
395965001208	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
395965001209	putative dimer interface [polypeptide binding]; other site
395965001210	N-terminal domain interface [polypeptide binding]; other site
395965001211	putative substrate binding pocket (H-site) [chemical binding]; other site
395965001212	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
395965001213	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395965001214	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965001215	active site
395965001216	phosphorylation site [posttranslational modification]
395965001217	intermolecular recognition site; other site
395965001218	dimerization interface [polypeptide binding]; other site
395965001219	response regulator PleD; Reviewed; Region: pleD; PRK09581
395965001220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965001221	active site
395965001222	phosphorylation site [posttranslational modification]
395965001223	intermolecular recognition site; other site
395965001224	dimerization interface [polypeptide binding]; other site
395965001225	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965001226	active site
395965001227	phosphorylation site [posttranslational modification]
395965001228	intermolecular recognition site; other site
395965001229	dimerization interface [polypeptide binding]; other site
395965001230	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395965001231	metal binding site [ion binding]; metal-binding site
395965001232	active site
395965001233	I-site; other site
395965001234	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
395965001235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965001236	Mg2+ binding site [ion binding]; other site
395965001237	G-X-G motif; other site
395965001238	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
395965001239	ATP binding site [chemical binding]; other site
395965001240	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
395965001241	active site
395965001242	metal binding site [ion binding]; metal-binding site
395965001243	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
395965001244	glutamine synthetase; Region: PLN02284
395965001245	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
395965001246	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
395965001247	glutamine synthetase; Provisional; Region: glnA; PRK09469
395965001248	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
395965001249	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
395965001250	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
395965001251	Nitrogen regulatory protein P-II; Region: P-II; smart00938
395965001252	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
395965001253	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
395965001254	active site residue [active]
395965001255	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
395965001256	active site residue [active]
395965001257	Trypsin; Region: Trypsin; pfam00089
395965001258	active site
395965001259	substrate binding sites [chemical binding]; other site
395965001260	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
395965001261	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395965001262	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965001263	active site
395965001264	phosphorylation site [posttranslational modification]
395965001265	intermolecular recognition site; other site
395965001266	dimerization interface [polypeptide binding]; other site
395965001267	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395965001268	DNA binding site [nucleotide binding]
395965001269	sensor protein PhoQ; Provisional; Region: PRK10815
395965001270	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965001271	ATP binding site [chemical binding]; other site
395965001272	Mg2+ binding site [ion binding]; other site
395965001273	G-X-G motif; other site
395965001274	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
395965001275	TPR repeat; Region: TPR_11; pfam13414
395965001276	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965001277	binding surface
395965001278	TPR motif; other site
395965001279	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
395965001280	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
395965001281	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
395965001282	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
395965001283	Predicted metalloprotease [General function prediction only]; Region: COG2321
395965001284	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
395965001285	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
395965001286	Fe-S cluster binding site [ion binding]; other site
395965001287	active site
395965001288	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
395965001289	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
395965001290	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
395965001291	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
395965001292	Predicted transcriptional regulators [Transcription]; Region: COG1733
395965001293	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395965001294	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
395965001295	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
395965001296	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
395965001297	putative FMN binding site [chemical binding]; other site
395965001298	Transcriptional activator [Transcription]; Region: ChrR; COG3806
395965001299	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
395965001300	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
395965001301	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
395965001302	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
395965001303	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395965001304	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
395965001305	lysine-2,3-aminomutase-related protein; Region: AblA_like_2; TIGR03822
395965001306	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395965001307	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
395965001308	motif 1; other site
395965001309	dimer interface [polypeptide binding]; other site
395965001310	active site
395965001311	motif 2; other site
395965001312	motif 3; other site
395965001313	elongation factor P; Validated; Region: PRK00529
395965001314	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
395965001315	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
395965001316	RNA binding site [nucleotide binding]; other site
395965001317	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
395965001318	RNA binding site [nucleotide binding]; other site
395965001319	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
395965001320	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395965001321	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395965001322	O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296
395965001323	Glycoside hydrolase family 71; Region: GH71; cd11577
395965001324	putative ligand binding site [chemical binding]; other site
395965001325	Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529
395965001326	putative catalytic site [active]
395965001327	Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100
395965001328	putative binding site; other site
395965001329	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
395965001330	Aspartase; Region: Aspartase; cd01357
395965001331	active sites [active]
395965001332	tetramer interface [polypeptide binding]; other site
395965001333	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
395965001334	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
395965001335	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
395965001336	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
395965001337	RNA binding site [nucleotide binding]; other site
395965001338	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395965001339	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
395965001340	Copper resistance protein D; Region: CopD; cl00563
395965001341	CopC domain; Region: CopC; pfam04234
395965001342	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
395965001343	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
395965001344	Trp docking motif [polypeptide binding]; other site
395965001345	dimer interface [polypeptide binding]; other site
395965001346	active site
395965001347	small subunit binding site [polypeptide binding]; other site
395965001348	methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870
395965001349	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395965001350	substrate binding pocket [chemical binding]; other site
395965001351	membrane-bound complex binding site; other site
395965001352	hinge residues; other site
395965001353	cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872
395965001354	Methanol dehydrogenase beta subunit; Region: MDH; pfam02315
395965001355	MoxR-like ATPases [General function prediction only]; Region: COG0714
395965001356	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965001357	Walker A motif; other site
395965001358	ATP binding site [chemical binding]; other site
395965001359	Walker B motif; other site
395965001360	arginine finger; other site
395965001361	Protein of unknown function DUF58; Region: DUF58; pfam01882
395965001362	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
395965001363	metal ion-dependent adhesion site (MIDAS); other site
395965001364	lipoprotein NlpI; Provisional; Region: PRK11189
395965001365	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
395965001366	metal ion-dependent adhesion site (MIDAS); other site
395965001367	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
395965001368	putative hydrophobic ligand binding site [chemical binding]; other site
395965001369	protein interface [polypeptide binding]; other site
395965001370	gate; other site
395965001371	Uncharacterized conserved protein [Function unknown]; Region: COG3391
395965001372	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
395965001373	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
395965001374	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
395965001375	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395965001376	dimerization interface [polypeptide binding]; other site
395965001377	Histidine kinase; Region: HisKA_3; pfam07730
395965001378	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965001379	ATP binding site [chemical binding]; other site
395965001380	Mg2+ binding site [ion binding]; other site
395965001381	G-X-G motif; other site
395965001382	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395965001383	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965001384	active site
395965001385	phosphorylation site [posttranslational modification]
395965001386	intermolecular recognition site; other site
395965001387	dimerization interface [polypeptide binding]; other site
395965001388	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395965001389	DNA binding residues [nucleotide binding]
395965001390	dimerization interface [polypeptide binding]; other site
395965001391	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
395965001392	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395965001393	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395965001394	metal binding site [ion binding]; metal-binding site
395965001395	active site
395965001396	I-site; other site
395965001397	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
395965001398	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
395965001399	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395965001400	catalytic residue [active]
395965001401	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
395965001402	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
395965001403	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
395965001404	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
395965001405	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395965001406	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
395965001407	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
395965001408	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
395965001409	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
395965001410	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
395965001411	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
395965001412	active site
395965001413	HIGH motif; other site
395965001414	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
395965001415	KMSK motif region; other site
395965001416	tRNA binding surface [nucleotide binding]; other site
395965001417	DALR anticodon binding domain; Region: DALR_1; smart00836
395965001418	anticodon binding site; other site
395965001419	Sporulation related domain; Region: SPOR; pfam05036
395965001420	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
395965001421	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
395965001422	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
395965001423	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
395965001424	dimer interface [polypeptide binding]; other site
395965001425	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965001426	catalytic residue [active]
395965001427	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
395965001428	amphipathic channel; other site
395965001429	Asn-Pro-Ala signature motifs; other site
395965001430	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
395965001431	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
395965001432	dimer interface [polypeptide binding]; other site
395965001433	putative functional site; other site
395965001434	putative MPT binding site; other site
395965001435	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
395965001436	trimer interface [polypeptide binding]; other site
395965001437	dimer interface [polypeptide binding]; other site
395965001438	putative active site [active]
395965001439	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
395965001440	active site
395965001441	ribulose/triose binding site [chemical binding]; other site
395965001442	phosphate binding site [ion binding]; other site
395965001443	substrate (anthranilate) binding pocket [chemical binding]; other site
395965001444	product (indole) binding pocket [chemical binding]; other site
395965001445	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
395965001446	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
395965001447	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
395965001448	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
395965001449	Glutamine amidotransferase class-I; Region: GATase; pfam00117
395965001450	glutamine binding [chemical binding]; other site
395965001451	catalytic triad [active]
395965001452	anthranilate synthase component I; Provisional; Region: PRK13573
395965001453	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
395965001454	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
395965001455	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
395965001456	SurA N-terminal domain; Region: SurA_N_3; cl07813
395965001457	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
395965001458	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
395965001459	triosephosphate isomerase; Provisional; Region: PRK14565
395965001460	substrate binding site [chemical binding]; other site
395965001461	dimer interface [polypeptide binding]; other site
395965001462	catalytic triad [active]
395965001463	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
395965001464	CTP synthetase; Validated; Region: pyrG; PRK05380
395965001465	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
395965001466	Catalytic site [active]
395965001467	active site
395965001468	UTP binding site [chemical binding]; other site
395965001469	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
395965001470	active site
395965001471	putative oxyanion hole; other site
395965001472	catalytic triad [active]
395965001473	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395965001474	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395965001475	active site
395965001476	catalytic tetrad [active]
395965001477	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
395965001478	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965001479	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965001480	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
395965001481	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395965001482	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395965001483	catalytic residue [active]
395965001484	enolase; Provisional; Region: eno; PRK00077
395965001485	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
395965001486	dimer interface [polypeptide binding]; other site
395965001487	metal binding site [ion binding]; metal-binding site
395965001488	substrate binding pocket [chemical binding]; other site
395965001489	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395965001490	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965001491	putative substrate translocation pore; other site
395965001492	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
395965001493	transmembrane helices; other site
395965001494	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
395965001495	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
395965001496	Septum formation initiator; Region: DivIC; cl17659
395965001497	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
395965001498	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
395965001499	tetramer interface [polypeptide binding]; other site
395965001500	TPP-binding site [chemical binding]; other site
395965001501	heterodimer interface [polypeptide binding]; other site
395965001502	phosphorylation loop region [posttranslational modification]
395965001503	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
395965001504	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395965001505	E3 interaction surface; other site
395965001506	lipoyl attachment site [posttranslational modification]; other site
395965001507	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
395965001508	alpha subunit interface [polypeptide binding]; other site
395965001509	TPP binding site [chemical binding]; other site
395965001510	heterodimer interface [polypeptide binding]; other site
395965001511	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395965001512	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395965001513	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
395965001514	E3 interaction surface; other site
395965001515	lipoyl attachment site [posttranslational modification]; other site
395965001516	e3 binding domain; Region: E3_binding; pfam02817
395965001517	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
395965001518	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
395965001519	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
395965001520	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395965001521	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395965001522	lipoyl synthase; Provisional; Region: PRK05481
395965001523	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395965001524	FeS/SAM binding site; other site
395965001525	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
395965001526	putative coenzyme Q binding site [chemical binding]; other site
395965001527	Competence-damaged protein; Region: CinA; pfam02464
395965001528	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
395965001529	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
395965001530	substrate binding site; other site
395965001531	dimer interface; other site
395965001532	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
395965001533	homotrimer interaction site [polypeptide binding]; other site
395965001534	zinc binding site [ion binding]; other site
395965001535	CDP-binding sites; other site
395965001536	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
395965001537	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
395965001538	FMN binding site [chemical binding]; other site
395965001539	active site
395965001540	catalytic residues [active]
395965001541	substrate binding site [chemical binding]; other site
395965001542	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
395965001543	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395965001544	putative active site [active]
395965001545	heme pocket [chemical binding]; other site
395965001546	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965001547	dimer interface [polypeptide binding]; other site
395965001548	phosphorylation site [posttranslational modification]
395965001549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965001550	ATP binding site [chemical binding]; other site
395965001551	Mg2+ binding site [ion binding]; other site
395965001552	G-X-G motif; other site
395965001553	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
395965001554	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965001555	active site
395965001556	phosphorylation site [posttranslational modification]
395965001557	intermolecular recognition site; other site
395965001558	dimerization interface [polypeptide binding]; other site
395965001559	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965001560	Walker A motif; other site
395965001561	ATP binding site [chemical binding]; other site
395965001562	Walker B motif; other site
395965001563	arginine finger; other site
395965001564	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
395965001565	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
395965001566	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395965001567	dimerization interface [polypeptide binding]; other site
395965001568	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965001569	dimer interface [polypeptide binding]; other site
395965001570	phosphorylation site [posttranslational modification]
395965001571	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965001572	ATP binding site [chemical binding]; other site
395965001573	Mg2+ binding site [ion binding]; other site
395965001574	G-X-G motif; other site
395965001575	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
395965001576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965001577	active site
395965001578	phosphorylation site [posttranslational modification]
395965001579	intermolecular recognition site; other site
395965001580	dimerization interface [polypeptide binding]; other site
395965001581	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965001582	Walker A motif; other site
395965001583	ATP binding site [chemical binding]; other site
395965001584	Walker B motif; other site
395965001585	arginine finger; other site
395965001586	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395965001587	Chromate transporter; Region: Chromate_transp; pfam02417
395965001588	Chromate transporter; Region: Chromate_transp; pfam02417
395965001589	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
395965001590	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
395965001591	homodimer interface [polypeptide binding]; other site
395965001592	substrate-cofactor binding pocket; other site
395965001593	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965001594	catalytic residue [active]
395965001595	bacterial Hfq-like; Region: Hfq; cd01716
395965001596	hexamer interface [polypeptide binding]; other site
395965001597	Sm1 motif; other site
395965001598	RNA binding site [nucleotide binding]; other site
395965001599	Sm2 motif; other site
395965001600	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
395965001601	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
395965001602	HflX GTPase family; Region: HflX; cd01878
395965001603	G1 box; other site
395965001604	GTP/Mg2+ binding site [chemical binding]; other site
395965001605	Switch I region; other site
395965001606	G2 box; other site
395965001607	G3 box; other site
395965001608	Switch II region; other site
395965001609	G4 box; other site
395965001610	G5 box; other site
395965001611	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
395965001612	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
395965001613	homodimer interface [polypeptide binding]; other site
395965001614	metal binding site [ion binding]; metal-binding site
395965001615	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
395965001616	homodimer interface [polypeptide binding]; other site
395965001617	active site
395965001618	putative chemical substrate binding site [chemical binding]; other site
395965001619	metal binding site [ion binding]; metal-binding site
395965001620	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395965001621	DNA-binding site [nucleotide binding]; DNA binding site
395965001622	RNA-binding motif; other site
395965001623	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395965001624	DNA-binding site [nucleotide binding]; DNA binding site
395965001625	RNA-binding motif; other site
395965001626	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
395965001627	putative hydrolase; Provisional; Region: PRK02113
395965001628	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
395965001629	active site
395965001630	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
395965001631	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
395965001632	active site
395965001633	HIGH motif; other site
395965001634	KMSKS motif; other site
395965001635	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
395965001636	tRNA binding surface [nucleotide binding]; other site
395965001637	anticodon binding site; other site
395965001638	DNA polymerase III subunit delta'; Validated; Region: PRK07471
395965001639	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
395965001640	active site
395965001641	DNA polymerase III subunit delta'; Validated; Region: PRK08485
395965001642	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
395965001643	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
395965001644	TMP-binding site; other site
395965001645	ATP-binding site [chemical binding]; other site
395965001646	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
395965001647	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
395965001648	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
395965001649	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
395965001650	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
395965001651	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
395965001652	additional DNA contacts [nucleotide binding]; other site
395965001653	mismatch recognition site; other site
395965001654	active site
395965001655	zinc binding site [ion binding]; other site
395965001656	DNA intercalation site [nucleotide binding]; other site
395965001657	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
395965001658	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
395965001659	cofactor binding site; other site
395965001660	DNA binding site [nucleotide binding]
395965001661	substrate interaction site [chemical binding]; other site
395965001662	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
395965001663	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
395965001664	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
395965001665	Moco binding site; other site
395965001666	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
395965001667	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395965001668	DNA-binding site [nucleotide binding]; DNA binding site
395965001669	RNA-binding motif; other site
395965001670	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395965001671	DNA-binding site [nucleotide binding]; DNA binding site
395965001672	RNA-binding motif; other site
395965001673	NAD-dependent deacetylase; Provisional; Region: PRK00481
395965001674	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
395965001675	NAD+ binding site [chemical binding]; other site
395965001676	substrate binding site [chemical binding]; other site
395965001677	Zn binding site [ion binding]; other site
395965001678	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
395965001679	oxyanion hole [active]
395965001680	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
395965001681	oxyanion hole [active]
395965001682	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
395965001683	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
395965001684	Predicted transcriptional regulator [Transcription]; Region: COG1959
395965001685	Transcriptional regulator; Region: Rrf2; pfam02082
395965001686	adenylate kinase; Reviewed; Region: adk; PRK00279
395965001687	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
395965001688	AMP-binding site [chemical binding]; other site
395965001689	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
395965001690	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
395965001691	SecY translocase; Region: SecY; pfam00344
395965001692	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
395965001693	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
395965001694	23S rRNA binding site [nucleotide binding]; other site
395965001695	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
395965001696	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
395965001697	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
395965001698	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
395965001699	5S rRNA interface [nucleotide binding]; other site
395965001700	23S rRNA interface [nucleotide binding]; other site
395965001701	L5 interface [polypeptide binding]; other site
395965001702	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
395965001703	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
395965001704	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
395965001705	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
395965001706	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
395965001707	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
395965001708	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
395965001709	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
395965001710	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
395965001711	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
395965001712	RNA binding site [nucleotide binding]; other site
395965001713	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
395965001714	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
395965001715	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
395965001716	23S rRNA interface [nucleotide binding]; other site
395965001717	putative translocon interaction site; other site
395965001718	signal recognition particle (SRP54) interaction site; other site
395965001719	L23 interface [polypeptide binding]; other site
395965001720	trigger factor interaction site; other site
395965001721	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
395965001722	23S rRNA interface [nucleotide binding]; other site
395965001723	5S rRNA interface [nucleotide binding]; other site
395965001724	putative antibiotic binding site [chemical binding]; other site
395965001725	L25 interface [polypeptide binding]; other site
395965001726	L27 interface [polypeptide binding]; other site
395965001727	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
395965001728	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
395965001729	G-X-X-G motif; other site
395965001730	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
395965001731	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
395965001732	putative translocon binding site; other site
395965001733	protein-rRNA interface [nucleotide binding]; other site
395965001734	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
395965001735	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
395965001736	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
395965001737	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
395965001738	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
395965001739	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
395965001740	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
395965001741	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
395965001742	elongation factor Tu; Reviewed; Region: PRK00049
395965001743	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
395965001744	G1 box; other site
395965001745	GEF interaction site [polypeptide binding]; other site
395965001746	GTP/Mg2+ binding site [chemical binding]; other site
395965001747	Switch I region; other site
395965001748	G2 box; other site
395965001749	G3 box; other site
395965001750	Switch II region; other site
395965001751	G4 box; other site
395965001752	G5 box; other site
395965001753	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
395965001754	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
395965001755	Antibiotic Binding Site [chemical binding]; other site
395965001756	elongation factor G; Reviewed; Region: PRK00007
395965001757	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
395965001758	G1 box; other site
395965001759	putative GEF interaction site [polypeptide binding]; other site
395965001760	GTP/Mg2+ binding site [chemical binding]; other site
395965001761	Switch I region; other site
395965001762	G2 box; other site
395965001763	G3 box; other site
395965001764	Switch II region; other site
395965001765	G4 box; other site
395965001766	G5 box; other site
395965001767	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
395965001768	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
395965001769	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
395965001770	30S ribosomal protein S7; Validated; Region: PRK05302
395965001771	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
395965001772	S17 interaction site [polypeptide binding]; other site
395965001773	S8 interaction site; other site
395965001774	16S rRNA interaction site [nucleotide binding]; other site
395965001775	streptomycin interaction site [chemical binding]; other site
395965001776	23S rRNA interaction site [nucleotide binding]; other site
395965001777	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
395965001778	seryl-tRNA synthetase; Provisional; Region: PRK05431
395965001779	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
395965001780	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
395965001781	dimer interface [polypeptide binding]; other site
395965001782	active site
395965001783	motif 1; other site
395965001784	motif 2; other site
395965001785	motif 3; other site
395965001786	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
395965001787	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
395965001788	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
395965001789	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
395965001790	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395965001791	PAS domain; Region: PAS_9; pfam13426
395965001792	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395965001793	Histidine kinase; Region: HisKA_2; pfam07568
395965001794	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965001795	ATP binding site [chemical binding]; other site
395965001796	Mg2+ binding site [ion binding]; other site
395965001797	G-X-G motif; other site
395965001798	HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3
395965001799	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395965001800	active site
395965001801	motif I; other site
395965001802	motif II; other site
395965001803	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395965001804	Novel bacterial esterase 713 that cleaves esters on halogenated cyclic compounds; Region: Esterase_713; cd12807
395965001805	catalytic site [active]
395965001806	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395965001807	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
395965001808	Part of AAA domain; Region: AAA_19; pfam13245
395965001809	Family description; Region: UvrD_C_2; pfam13538
395965001810	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
395965001811	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
395965001812	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
395965001813	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
395965001814	thymidylate synthase; Reviewed; Region: thyA; PRK01827
395965001815	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
395965001816	dimerization interface [polypeptide binding]; other site
395965001817	active site
395965001818	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395965001819	Coenzyme A binding pocket [chemical binding]; other site
395965001820	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
395965001821	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
395965001822	folate binding site [chemical binding]; other site
395965001823	NADP+ binding site [chemical binding]; other site
395965001824	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
395965001825	HflK protein; Region: hflK; TIGR01933
395965001826	HflC protein; Region: hflC; TIGR01932
395965001827	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
395965001828	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395965001829	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395965001830	protein binding site [polypeptide binding]; other site
395965001831	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395965001832	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
395965001833	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
395965001834	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
395965001835	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395965001836	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
395965001837	Soluble P-type ATPase [General function prediction only]; Region: COG4087
395965001838	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
395965001839	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
395965001840	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
395965001841	NADP binding site [chemical binding]; other site
395965001842	dimer interface [polypeptide binding]; other site
395965001843	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
395965001844	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
395965001845	cytidylate kinase; Provisional; Region: cmk; PRK00023
395965001846	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
395965001847	CMP-binding site; other site
395965001848	The sites determining sugar specificity; other site
395965001849	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
395965001850	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
395965001851	hinge; other site
395965001852	active site
395965001853	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
395965001854	TIGR02300 family protein; Region: FYDLN_acid
395965001855	Flagellin N-methylase; Region: FliB; cl00497
395965001856	fructokinase; Reviewed; Region: PRK09557
395965001857	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
395965001858	nucleotide binding site [chemical binding]; other site
395965001859	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
395965001860	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
395965001861	dimerization interface [polypeptide binding]; other site
395965001862	DPS ferroxidase diiron center [ion binding]; other site
395965001863	ion pore; other site
395965001864	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
395965001865	putative metal binding site [ion binding]; other site
395965001866	Predicted integral membrane protein [Function unknown]; Region: COG5473
395965001867	Short C-terminal domain; Region: SHOCT; pfam09851
395965001868	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
395965001869	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
395965001870	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395965001871	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
395965001872	putative C-terminal domain interface [polypeptide binding]; other site
395965001873	putative GSH binding site (G-site) [chemical binding]; other site
395965001874	putative dimer interface [polypeptide binding]; other site
395965001875	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
395965001876	putative N-terminal domain interface [polypeptide binding]; other site
395965001877	putative dimer interface [polypeptide binding]; other site
395965001878	putative substrate binding pocket (H-site) [chemical binding]; other site
395965001879	Cupin domain; Region: Cupin_2; cl17218
395965001880	succinylarginine dihydrolase; Provisional; Region: PRK13281
395965001881	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
395965001882	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
395965001883	Protein export membrane protein; Region: SecD_SecF; cl14618
395965001884	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395965001885	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965001886	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965001887	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
395965001888	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
395965001889	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
395965001890	nucleophile elbow; other site
395965001891	Patatin phospholipase; Region: DUF3734; pfam12536
395965001892	septum formation inhibitor; Reviewed; Region: minC; PRK05177
395965001893	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
395965001894	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
395965001895	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
395965001896	Switch I; other site
395965001897	Switch II; other site
395965001898	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
395965001899	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
395965001900	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
395965001901	substrate binding site [chemical binding]; other site
395965001902	ligand binding site [chemical binding]; other site
395965001903	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
395965001904	putative dimer interface [polypeptide binding]; other site
395965001905	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395965001906	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
395965001907	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395965001908	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395965001909	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
395965001910	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
395965001911	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
395965001912	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
395965001913	putative active site [active]
395965001914	Ap4A binding site [chemical binding]; other site
395965001915	nudix motif; other site
395965001916	putative metal binding site [ion binding]; other site
395965001917	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
395965001918	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
395965001919	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
395965001920	protein binding site [polypeptide binding]; other site
395965001921	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
395965001922	Catalytic dyad [active]
395965001923	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
395965001924	Peptidase family M23; Region: Peptidase_M23; pfam01551
395965001925	methionine sulfoxide reductase B; Provisional; Region: PRK00222
395965001926	SelR domain; Region: SelR; pfam01641
395965001927	methionine sulfoxide reductase A; Provisional; Region: PRK13014
395965001928	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
395965001929	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
395965001930	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
395965001931	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
395965001932	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
395965001933	DNA binding residues [nucleotide binding]
395965001934	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
395965001935	IHF dimer interface [polypeptide binding]; other site
395965001936	IHF - DNA interface [nucleotide binding]; other site
395965001937	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
395965001938	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
395965001939	dimer interface [polypeptide binding]; other site
395965001940	active site
395965001941	CoA binding pocket [chemical binding]; other site
395965001942	putative phosphate acyltransferase; Provisional; Region: PRK05331
395965001943	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
395965001944	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045
395965001945	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
395965001946	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
395965001947	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808
395965001948	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
395965001949	thiamine-monophosphate kinase; Region: thiL; TIGR01379
395965001950	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
395965001951	dimerization interface [polypeptide binding]; other site
395965001952	ATP binding site [chemical binding]; other site
395965001953	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
395965001954	putative RNA binding site [nucleotide binding]; other site
395965001955	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
395965001956	homopentamer interface [polypeptide binding]; other site
395965001957	active site
395965001958	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
395965001959	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
395965001960	Predicted kinase [General function prediction only]; Region: COG0645
395965001961	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
395965001962	active site
395965001963	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
395965001964	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
395965001965	putative ribose interaction site [chemical binding]; other site
395965001966	putative ADP binding site [chemical binding]; other site
395965001967	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
395965001968	active site
395965001969	nucleotide binding site [chemical binding]; other site
395965001970	HIGH motif; other site
395965001971	KMSKS motif; other site
395965001972	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
395965001973	dimerization interface [polypeptide binding]; other site
395965001974	putative active cleft [active]
395965001975	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
395965001976	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
395965001977	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965001978	Walker A motif; other site
395965001979	ATP binding site [chemical binding]; other site
395965001980	Walker B motif; other site
395965001981	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
395965001982	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
395965001983	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
395965001984	Substrate binding site; other site
395965001985	metal-binding site
395965001986	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
395965001987	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
395965001988	Phosphotransferase enzyme family; Region: APH; pfam01636
395965001989	PAS fold; Region: PAS_7; pfam12860
395965001990	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395965001991	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965001992	dimer interface [polypeptide binding]; other site
395965001993	phosphorylation site [posttranslational modification]
395965001994	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965001995	ATP binding site [chemical binding]; other site
395965001996	Mg2+ binding site [ion binding]; other site
395965001997	G-X-G motif; other site
395965001998	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395965001999	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395965002000	active site
395965002001	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395965002002	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395965002003	active site
395965002004	catalytic tetrad [active]
395965002005	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
395965002006	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
395965002007	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
395965002008	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395965002009	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395965002010	putative DNA binding site [nucleotide binding]; other site
395965002011	putative Zn2+ binding site [ion binding]; other site
395965002012	AsnC family; Region: AsnC_trans_reg; pfam01037
395965002013	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
395965002014	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395965002015	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
395965002016	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
395965002017	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395965002018	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395965002019	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
395965002020	IMP binding site; other site
395965002021	dimer interface [polypeptide binding]; other site
395965002022	interdomain contacts; other site
395965002023	partial ornithine binding site; other site
395965002024	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
395965002025	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
395965002026	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
395965002027	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
395965002028	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
395965002029	nucleotide binding site [chemical binding]; other site
395965002030	putative NEF/HSP70 interaction site [polypeptide binding]; other site
395965002031	SBD interface [polypeptide binding]; other site
395965002032	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
395965002033	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
395965002034	RNA binding site [nucleotide binding]; other site
395965002035	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
395965002036	RNA binding site [nucleotide binding]; other site
395965002037	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
395965002038	RNA binding site [nucleotide binding]; other site
395965002039	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
395965002040	RNA binding site [nucleotide binding]; other site
395965002041	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
395965002042	RNA binding site [nucleotide binding]; other site
395965002043	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
395965002044	RNA binding site [nucleotide binding]; other site
395965002045	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
395965002046	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
395965002047	active site residue [active]
395965002048	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
395965002049	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
395965002050	GTP binding site; other site
395965002051	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
395965002052	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
395965002053	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
395965002054	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
395965002055	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
395965002056	active site
395965002057	Riboflavin kinase; Region: Flavokinase; smart00904
395965002058	2-isopropylmalate synthase; Validated; Region: PRK00915
395965002059	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
395965002060	active site
395965002061	catalytic residues [active]
395965002062	metal binding site [ion binding]; metal-binding site
395965002063	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
395965002064	Carboxylesterase family; Region: COesterase; pfam00135
395965002065	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
395965002066	substrate binding pocket [chemical binding]; other site
395965002067	catalytic triad [active]
395965002068	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
395965002069	catalytic site [active]
395965002070	Novel bacterial esterase 713 that cleaves esters on halogenated cyclic compounds; Region: Esterase_713; cd12807
395965002071	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
395965002072	catalytic site [active]
395965002073	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395965002074	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395965002075	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395965002076	active site
395965002077	catalytic tetrad [active]
395965002078	putative acyl transferase; Provisional; Region: PRK10502
395965002079	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
395965002080	putative trimer interface [polypeptide binding]; other site
395965002081	putative active site [active]
395965002082	putative substrate binding site [chemical binding]; other site
395965002083	putative CoA binding site [chemical binding]; other site
395965002084	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395965002085	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
395965002086	putative ADP-binding pocket [chemical binding]; other site
395965002087	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
395965002088	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
395965002089	active site
395965002090	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
395965002091	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965002092	dimer interface [polypeptide binding]; other site
395965002093	conserved gate region; other site
395965002094	putative PBP binding loops; other site
395965002095	ABC-ATPase subunit interface; other site
395965002096	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965002097	dimer interface [polypeptide binding]; other site
395965002098	conserved gate region; other site
395965002099	putative PBP binding loops; other site
395965002100	ABC-ATPase subunit interface; other site
395965002101	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395965002102	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395965002103	Walker A/P-loop; other site
395965002104	ATP binding site [chemical binding]; other site
395965002105	Q-loop/lid; other site
395965002106	ABC transporter signature motif; other site
395965002107	Walker B; other site
395965002108	D-loop; other site
395965002109	H-loop/switch region; other site
395965002110	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
395965002111	Autoinducer binding domain; Region: Autoind_bind; pfam03472
395965002112	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
395965002113	DNA binding residues [nucleotide binding]
395965002114	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
395965002115	MgtE intracellular N domain; Region: MgtE_N; smart00924
395965002116	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
395965002117	Divalent cation transporter; Region: MgtE; cl00786
395965002118	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
395965002119	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
395965002120	NodB motif; other site
395965002121	active site
395965002122	catalytic site [active]
395965002123	metal binding site [ion binding]; metal-binding site
395965002124	lipoate-protein ligase B; Provisional; Region: PRK14341
395965002125	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395965002126	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395965002127	Walker A/P-loop; other site
395965002128	ATP binding site [chemical binding]; other site
395965002129	Q-loop/lid; other site
395965002130	ABC transporter signature motif; other site
395965002131	Walker B; other site
395965002132	D-loop; other site
395965002133	H-loop/switch region; other site
395965002134	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
395965002135	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
395965002136	FtsX-like permease family; Region: FtsX; pfam02687
395965002137	prolyl-tRNA synthetase; Provisional; Region: PRK12325
395965002138	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
395965002139	dimer interface [polypeptide binding]; other site
395965002140	motif 1; other site
395965002141	active site
395965002142	motif 2; other site
395965002143	motif 3; other site
395965002144	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
395965002145	anticodon binding site; other site
395965002146	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
395965002147	putative active site [active]
395965002148	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
395965002149	MAPEG family; Region: MAPEG; cl09190
395965002150	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
395965002151	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395965002152	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395965002153	Coenzyme A binding pocket [chemical binding]; other site
395965002154	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
395965002155	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
395965002156	glutaminase active site [active]
395965002157	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
395965002158	dimer interface [polypeptide binding]; other site
395965002159	active site
395965002160	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
395965002161	dimer interface [polypeptide binding]; other site
395965002162	active site
395965002163	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
395965002164	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
395965002165	Substrate binding site; other site
395965002166	Mg++ binding site; other site
395965002167	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
395965002168	active site
395965002169	substrate binding site [chemical binding]; other site
395965002170	CoA binding site [chemical binding]; other site
395965002171	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
395965002172	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
395965002173	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395965002174	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
395965002175	Ligand binding site; other site
395965002176	DXD motif; other site
395965002177	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395965002178	active site
395965002179	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395965002180	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395965002181	active site
395965002182	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635
395965002183	pyruvate phosphate dikinase; Provisional; Region: PRK09279
395965002184	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
395965002185	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
395965002186	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
395965002187	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
395965002188	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
395965002189	TPP-binding site; other site
395965002190	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
395965002191	PYR/PP interface [polypeptide binding]; other site
395965002192	dimer interface [polypeptide binding]; other site
395965002193	TPP binding site [chemical binding]; other site
395965002194	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395965002195	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395965002196	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
395965002197	RNA binding surface [nucleotide binding]; other site
395965002198	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
395965002199	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
395965002200	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965002201	S-adenosylmethionine binding site [chemical binding]; other site
395965002202	Rhomboid family; Region: Rhomboid; pfam01694
395965002203	peptide chain release factor 2; Validated; Region: prfB; PRK00578
395965002204	This domain is found in peptide chain release factors; Region: PCRF; smart00937
395965002205	RF-1 domain; Region: RF-1; pfam00472
395965002206	Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140
395965002207	Cupin; Region: Cupin_1; smart00835
395965002208	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
395965002209	Transglycosylase; Region: Transgly; pfam00912
395965002210	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
395965002211	AMIN domain; Region: AMIN; pfam11741
395965002212	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
395965002213	active site
395965002214	metal binding site [ion binding]; metal-binding site
395965002215	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
395965002216	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
395965002217	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
395965002218	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
395965002219	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
395965002220	catalytic residues [active]
395965002221	Cytochrome P450; Region: p450; cl12078
395965002222	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
395965002223	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
395965002224	FAD binding domain; Region: FAD_binding_4; pfam01565
395965002225	Porin subfamily; Region: Porin_2; pfam02530
395965002226	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
395965002227	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
395965002228	GatB domain; Region: GatB_Yqey; smart00845
395965002229	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
395965002230	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
395965002231	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
395965002232	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395965002233	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395965002234	Serine hydrolase; Region: Ser_hydrolase; cl17834
395965002235	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
395965002236	metal-dependent hydrolase; Provisional; Region: PRK00685
395965002237	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
395965002238	amino acid transporter; Region: 2A0306; TIGR00909
395965002239	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
395965002240	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395965002241	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
395965002242	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
395965002243	Protein of unknown function, DUF482; Region: DUF482; pfam04339
395965002244	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
395965002245	HIT family signature motif; other site
395965002246	catalytic residue [active]
395965002247	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
395965002248	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965002249	Walker A motif; other site
395965002250	ATP binding site [chemical binding]; other site
395965002251	Walker B motif; other site
395965002252	arginine finger; other site
395965002253	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965002254	Walker A motif; other site
395965002255	ATP binding site [chemical binding]; other site
395965002256	Walker B motif; other site
395965002257	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
395965002258	Uncharacterized conserved protein [Function unknown]; Region: COG2127
395965002259	Phasin protein; Region: Phasin_2; pfam09361
395965002260	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
395965002261	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
395965002262	Sporulation related domain; Region: SPOR; pfam05036
395965002263	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395965002264	HSP70 interaction site [polypeptide binding]; other site
395965002265	von Willebrand factor type A domain; Region: VWA_2; pfam13519
395965002266	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
395965002267	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395965002268	putative C-terminal domain interface [polypeptide binding]; other site
395965002269	putative GSH binding site (G-site) [chemical binding]; other site
395965002270	putative dimer interface [polypeptide binding]; other site
395965002271	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
395965002272	putative N-terminal domain interface [polypeptide binding]; other site
395965002273	putative dimer interface [polypeptide binding]; other site
395965002274	putative substrate binding pocket (H-site) [chemical binding]; other site
395965002275	Protein of unknown function, DUF599; Region: DUF599; cl01575
395965002276	Uncharacterized conserved protein [Function unknown]; Region: COG1434
395965002277	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
395965002278	putative active site [active]
395965002279	Domain of unknown function (DUF329); Region: DUF329; cl01144
395965002280	Maf-like protein; Region: Maf; pfam02545
395965002281	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
395965002282	active site
395965002283	dimer interface [polypeptide binding]; other site
395965002284	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
395965002285	rRNA binding site [nucleotide binding]; other site
395965002286	predicted 30S ribosome binding site; other site
395965002287	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
395965002288	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
395965002289	Phosphotransferase enzyme family; Region: APH; pfam01636
395965002290	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
395965002291	active site
395965002292	substrate binding site [chemical binding]; other site
395965002293	ATP binding site [chemical binding]; other site
395965002294	GTP-binding protein Der; Reviewed; Region: PRK00093
395965002295	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
395965002296	G1 box; other site
395965002297	GTP/Mg2+ binding site [chemical binding]; other site
395965002298	Switch I region; other site
395965002299	G2 box; other site
395965002300	Switch II region; other site
395965002301	G3 box; other site
395965002302	G4 box; other site
395965002303	G5 box; other site
395965002304	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
395965002305	G1 box; other site
395965002306	GTP/Mg2+ binding site [chemical binding]; other site
395965002307	Switch I region; other site
395965002308	G2 box; other site
395965002309	G3 box; other site
395965002310	Switch II region; other site
395965002311	G4 box; other site
395965002312	G5 box; other site
395965002313	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
395965002314	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395965002315	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395965002316	active site
395965002317	catalytic tetrad [active]
395965002318	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
395965002319	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395965002320	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395965002321	substrate binding pocket [chemical binding]; other site
395965002322	membrane-bound complex binding site; other site
395965002323	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395965002324	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965002325	dimer interface [polypeptide binding]; other site
395965002326	conserved gate region; other site
395965002327	putative PBP binding loops; other site
395965002328	ABC-ATPase subunit interface; other site
395965002329	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395965002330	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395965002331	Walker A/P-loop; other site
395965002332	ATP binding site [chemical binding]; other site
395965002333	Q-loop/lid; other site
395965002334	ABC transporter signature motif; other site
395965002335	Walker B; other site
395965002336	D-loop; other site
395965002337	H-loop/switch region; other site
395965002338	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
395965002339	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
395965002340	active site
395965002341	dimer interface [polypeptide binding]; other site
395965002342	non-prolyl cis peptide bond; other site
395965002343	insertion regions; other site
395965002344	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
395965002345	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
395965002346	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395965002347	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965002348	dimer interface [polypeptide binding]; other site
395965002349	conserved gate region; other site
395965002350	putative PBP binding loops; other site
395965002351	ABC-ATPase subunit interface; other site
395965002352	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395965002353	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395965002354	Walker A/P-loop; other site
395965002355	ATP binding site [chemical binding]; other site
395965002356	Q-loop/lid; other site
395965002357	ABC transporter signature motif; other site
395965002358	Walker B; other site
395965002359	D-loop; other site
395965002360	H-loop/switch region; other site
395965002361	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395965002362	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395965002363	substrate binding pocket [chemical binding]; other site
395965002364	membrane-bound complex binding site; other site
395965002365	hinge residues; other site
395965002366	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
395965002367	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
395965002368	active site
395965002369	substrate binding site [chemical binding]; other site
395965002370	metal binding site [ion binding]; metal-binding site
395965002371	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
395965002372	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965002373	TPR motif; other site
395965002374	binding surface
395965002375	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
395965002376	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
395965002377	Ligand Binding Site [chemical binding]; other site
395965002378	FtsH Extracellular; Region: FtsH_ext; pfam06480
395965002379	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
395965002380	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965002381	Walker A motif; other site
395965002382	ATP binding site [chemical binding]; other site
395965002383	Walker B motif; other site
395965002384	arginine finger; other site
395965002385	Peptidase family M41; Region: Peptidase_M41; pfam01434
395965002386	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
395965002387	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
395965002388	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
395965002389	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395965002390	ligand binding site [chemical binding]; other site
395965002391	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
395965002392	Protein of unknown function DUF58; Region: DUF58; pfam01882
395965002393	MoxR-like ATPases [General function prediction only]; Region: COG0714
395965002394	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
395965002395	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
395965002396	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
395965002397	putative active site [active]
395965002398	putative CoA binding site [chemical binding]; other site
395965002399	nudix motif; other site
395965002400	metal binding site [ion binding]; metal-binding site
395965002401	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
395965002402	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
395965002403	active site
395965002404	NTP binding site [chemical binding]; other site
395965002405	metal binding triad [ion binding]; metal-binding site
395965002406	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395965002407	short chain dehydrogenase; Provisional; Region: PRK09134
395965002408	NAD(P) binding site [chemical binding]; other site
395965002409	active site
395965002410	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
395965002411	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
395965002412	oligomerisation interface [polypeptide binding]; other site
395965002413	mobile loop; other site
395965002414	roof hairpin; other site
395965002415	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
395965002416	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
395965002417	ring oligomerisation interface [polypeptide binding]; other site
395965002418	ATP/Mg binding site [chemical binding]; other site
395965002419	stacking interactions; other site
395965002420	hinge regions; other site
395965002421	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
395965002422	IHF - DNA interface [nucleotide binding]; other site
395965002423	IHF dimer interface [polypeptide binding]; other site
395965002424	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
395965002425	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
395965002426	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
395965002427	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395965002428	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395965002429	ligand binding site [chemical binding]; other site
395965002430	flexible hinge region; other site
395965002431	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
395965002432	putative switch regulator; other site
395965002433	non-specific DNA interactions [nucleotide binding]; other site
395965002434	DNA binding site [nucleotide binding]
395965002435	sequence specific DNA binding site [nucleotide binding]; other site
395965002436	putative cAMP binding site [chemical binding]; other site
395965002437	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
395965002438	ATP phosphoribosyltransferase; Region: HisG; cl15266
395965002439	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
395965002440	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395965002441	motif 1; other site
395965002442	dimer interface [polypeptide binding]; other site
395965002443	active site
395965002444	motif 2; other site
395965002445	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395965002446	active site
395965002447	motif 3; other site
395965002448	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
395965002449	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
395965002450	dimer interface [polypeptide binding]; other site
395965002451	motif 1; other site
395965002452	motif 2; other site
395965002453	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
395965002454	active site
395965002455	motif 3; other site
395965002456	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
395965002457	anticodon binding site; other site
395965002458	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
395965002459	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395965002460	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
395965002461	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
395965002462	ATP binding site [chemical binding]; other site
395965002463	Mg++ binding site [ion binding]; other site
395965002464	motif III; other site
395965002465	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395965002466	nucleotide binding region [chemical binding]; other site
395965002467	ATP-binding site [chemical binding]; other site
395965002468	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
395965002469	DinB superfamily; Region: DinB_2; pfam12867
395965002470	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
395965002471	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
395965002472	active site
395965002473	nucleophile elbow; other site
395965002474	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395965002475	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
395965002476	NAD(P) binding site [chemical binding]; other site
395965002477	active site
395965002478	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
395965002479	metal binding site 2 [ion binding]; metal-binding site
395965002480	putative DNA binding helix; other site
395965002481	metal binding site 1 [ion binding]; metal-binding site
395965002482	dimer interface [polypeptide binding]; other site
395965002483	structural Zn2+ binding site [ion binding]; other site
395965002484	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
395965002485	putative active site [active]
395965002486	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
395965002487	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
395965002488	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
395965002489	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
395965002490	HSP70 interaction site [polypeptide binding]; other site
395965002491	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
395965002492	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
395965002493	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
395965002494	substrate binding pocket [chemical binding]; other site
395965002495	chain length determination region; other site
395965002496	substrate-Mg2+ binding site; other site
395965002497	catalytic residues [active]
395965002498	aspartate-rich region 1; other site
395965002499	active site lid residues [active]
395965002500	aspartate-rich region 2; other site
395965002501	Transglycosylase; Region: Transgly; cl17702
395965002502	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
395965002503	transaldolase-like protein; Provisional; Region: PTZ00411
395965002504	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
395965002505	active site
395965002506	dimer interface [polypeptide binding]; other site
395965002507	catalytic residue [active]
395965002508	EF-hand domain pair; Region: EF_hand_5; pfam13499
395965002509	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
395965002510	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
395965002511	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
395965002512	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
395965002513	tonB-system energizer ExbB; Region: exbB; TIGR02797
395965002514	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
395965002515	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
395965002516	active site
395965002517	FMN binding site [chemical binding]; other site
395965002518	substrate binding site [chemical binding]; other site
395965002519	3Fe-4S cluster binding site [ion binding]; other site
395965002520	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395965002521	Ligand Binding Site [chemical binding]; other site
395965002522	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
395965002523	Part of AAA domain; Region: AAA_19; pfam13245
395965002524	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
395965002525	AAA domain; Region: AAA_12; pfam13087
395965002526	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
395965002527	putative active site [active]
395965002528	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
395965002529	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
395965002530	dimerization interface [polypeptide binding]; other site
395965002531	domain crossover interface; other site
395965002532	redox-dependent activation switch; other site
395965002533	ornithine carbamoyltransferase; Provisional; Region: PRK00779
395965002534	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
395965002535	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
395965002536	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
395965002537	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395965002538	inhibitor-cofactor binding pocket; inhibition site
395965002539	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965002540	catalytic residue [active]
395965002541	GcrA cell cycle regulator; Region: GcrA; cl11564
395965002542	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
395965002543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965002544	active site
395965002545	phosphorylation site [posttranslational modification]
395965002546	intermolecular recognition site; other site
395965002547	dimerization interface [polypeptide binding]; other site
395965002548	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395965002549	DNA binding site [nucleotide binding]
395965002550	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
395965002551	PhoU domain; Region: PhoU; pfam01895
395965002552	PhoU domain; Region: PhoU; pfam01895
395965002553	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
395965002554	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
395965002555	Walker A/P-loop; other site
395965002556	ATP binding site [chemical binding]; other site
395965002557	Q-loop/lid; other site
395965002558	ABC transporter signature motif; other site
395965002559	Walker B; other site
395965002560	D-loop; other site
395965002561	H-loop/switch region; other site
395965002562	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
395965002563	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965002564	dimer interface [polypeptide binding]; other site
395965002565	conserved gate region; other site
395965002566	putative PBP binding loops; other site
395965002567	ABC-ATPase subunit interface; other site
395965002568	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
395965002569	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965002570	dimer interface [polypeptide binding]; other site
395965002571	conserved gate region; other site
395965002572	putative PBP binding loops; other site
395965002573	ABC-ATPase subunit interface; other site
395965002574	PBP superfamily domain; Region: PBP_like_2; cl17296
395965002575	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
395965002576	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965002577	dimer interface [polypeptide binding]; other site
395965002578	phosphorylation site [posttranslational modification]
395965002579	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965002580	ATP binding site [chemical binding]; other site
395965002581	Mg2+ binding site [ion binding]; other site
395965002582	G-X-G motif; other site
395965002583	Predicted integral membrane protein [Function unknown]; Region: COG0392
395965002584	phosphodiesterase YaeI; Provisional; Region: PRK11340
395965002585	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
395965002586	putative active site [active]
395965002587	putative metal binding site [ion binding]; other site
395965002588	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
395965002589	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
395965002590	putative active site [active]
395965002591	Zn binding site [ion binding]; other site
395965002592	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395965002593	non-specific DNA binding site [nucleotide binding]; other site
395965002594	salt bridge; other site
395965002595	sequence-specific DNA binding site [nucleotide binding]; other site
395965002596	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
395965002597	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
395965002598	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
395965002599	dimerization interface [polypeptide binding]; other site
395965002600	active site
395965002601	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
395965002602	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
395965002603	Tetramer interface [polypeptide binding]; other site
395965002604	active site
395965002605	FMN-binding site [chemical binding]; other site
395965002606	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
395965002607	SmpB-tmRNA interface; other site
395965002608	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
395965002609	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
395965002610	dimer interface [polypeptide binding]; other site
395965002611	active site
395965002612	catalytic residue [active]
395965002613	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
395965002614	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395965002615	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395965002616	catalytic residue [active]
395965002617	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965002618	Response regulator receiver domain; Region: Response_reg; pfam00072
395965002619	active site
395965002620	phosphorylation site [posttranslational modification]
395965002621	intermolecular recognition site; other site
395965002622	dimerization interface [polypeptide binding]; other site
395965002623	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395965002624	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
395965002625	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
395965002626	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
395965002627	RNA polymerase sigma factor; Provisional; Region: PRK11924
395965002628	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395965002629	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395965002630	DNA binding residues [nucleotide binding]
395965002631	Condensation domain; Region: Condensation; pfam00668
395965002632	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
395965002633	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
395965002634	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
395965002635	acyl-activating enzyme (AAE) consensus motif; other site
395965002636	AMP binding site [chemical binding]; other site
395965002637	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
395965002638	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
395965002639	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
395965002640	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965002641	putative substrate translocation pore; other site
395965002642	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
395965002643	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
395965002644	active site
395965002645	nucleophile elbow; other site
395965002646	Patatin phospholipase; Region: DUF3734; pfam12536
395965002647	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
395965002648	putative catalytic residues [active]
395965002649	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395965002650	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965002651	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
395965002652	dimerization interface [polypeptide binding]; other site
395965002653	Cupin domain; Region: Cupin_2; cl17218
395965002654	bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108
395965002655	Moco binding site; other site
395965002656	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
395965002657	metal coordination site [ion binding]; other site
395965002658	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
395965002659	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
395965002660	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
395965002661	pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953
395965002662	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
395965002663	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
395965002664	active site
395965002665	FMN binding site [chemical binding]; other site
395965002666	substrate binding site [chemical binding]; other site
395965002667	3Fe-4S cluster binding site [ion binding]; other site
395965002668	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
395965002669	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
395965002670	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
395965002671	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395965002672	catalytic residues [active]
395965002673	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
395965002674	methionine sulfoxide reductase A; Provisional; Region: PRK14054
395965002675	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965002676	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395965002677	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
395965002678	putative NAD(P) binding site [chemical binding]; other site
395965002679	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965002680	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395965002681	putative substrate translocation pore; other site
395965002682	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
395965002683	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
395965002684	Uncharacterized conserved protein [Function unknown]; Region: COG3791
395965002685	Putative ParB-like nuclease; Region: ParBc_2; cl17538
395965002686	Acylphosphatase; Region: Acylphosphatase; pfam00708
395965002687	Helix-turn-helix domain; Region: HTH_18; pfam12833
395965002688	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395965002689	Methyltransferase domain; Region: Methyltransf_24; pfam13578
395965002690	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
395965002691	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
395965002692	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
395965002693	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
395965002694	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
395965002695	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395965002696	FeS/SAM binding site; other site
395965002697	YceG-like family; Region: YceG; pfam02618
395965002698	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
395965002699	dimerization interface [polypeptide binding]; other site
395965002700	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
395965002701	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
395965002702	dimer interface [polypeptide binding]; other site
395965002703	active site
395965002704	acyl carrier protein; Provisional; Region: acpP; PRK00982
395965002705	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395965002706	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
395965002707	NAD(P) binding site [chemical binding]; other site
395965002708	active site
395965002709	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
395965002710	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
395965002711	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
395965002712	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
395965002713	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
395965002714	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
395965002715	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
395965002716	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
395965002717	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395965002718	substrate binding site [chemical binding]; other site
395965002719	oxyanion hole (OAH) forming residues; other site
395965002720	trimer interface [polypeptide binding]; other site
395965002721	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
395965002722	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
395965002723	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395965002724	Sel1-like repeats; Region: SEL1; smart00671
395965002725	Sel1-like repeats; Region: SEL1; smart00671
395965002726	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
395965002727	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
395965002728	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
395965002729	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
395965002730	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
395965002731	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
395965002732	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
395965002733	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395965002734	Walker A motif; other site
395965002735	ATP binding site [chemical binding]; other site
395965002736	Walker B motif; other site
395965002737	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
395965002738	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
395965002739	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
395965002740	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
395965002741	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
395965002742	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
395965002743	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
395965002744	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
395965002745	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
395965002746	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
395965002747	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
395965002748	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
395965002749	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
395965002750	TolR protein; Region: tolR; TIGR02801
395965002751	TolQ protein; Region: tolQ; TIGR02796
395965002752	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
395965002753	active site
395965002754	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
395965002755	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
395965002756	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
395965002757	EVE domain; Region: EVE; pfam01878
395965002758	Novel bacterial esterase 713 that cleaves esters on halogenated cyclic compounds; Region: Esterase_713; cd12807
395965002759	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395965002760	catalytic site [active]
395965002761	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
395965002762	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
395965002763	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
395965002764	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
395965002765	iron-sulfur cluster [ion binding]; other site
395965002766	[2Fe-2S] cluster binding site [ion binding]; other site
395965002767	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
395965002768	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
395965002769	homotetramer interface [polypeptide binding]; other site
395965002770	ligand binding site [chemical binding]; other site
395965002771	catalytic site [active]
395965002772	NAD binding site [chemical binding]; other site
395965002773	Cupin domain; Region: Cupin_2; pfam07883
395965002774	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
395965002775	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395965002776	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
395965002777	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
395965002778	sulfotransferase; Region: PLN02164
395965002779	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
395965002780	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
395965002781	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
395965002782	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
395965002783	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
395965002784	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
395965002785	Walker A/P-loop; other site
395965002786	ATP binding site [chemical binding]; other site
395965002787	Q-loop/lid; other site
395965002788	ABC transporter signature motif; other site
395965002789	Walker B; other site
395965002790	D-loop; other site
395965002791	H-loop/switch region; other site
395965002792	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
395965002793	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395965002794	Domain of unknown function (DUF336); Region: DUF336; cl01249
395965002795	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
395965002796	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395965002797	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395965002798	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965002799	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965002800	multidrug efflux protein; Reviewed; Region: PRK09579
395965002801	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
395965002802	catalytic residues [active]
395965002803	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
395965002804	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
395965002805	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
395965002806	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395965002807	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395965002808	non-specific DNA binding site [nucleotide binding]; other site
395965002809	salt bridge; other site
395965002810	sequence-specific DNA binding site [nucleotide binding]; other site
395965002811	Cupin domain; Region: Cupin_2; pfam07883
395965002812	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395965002813	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
395965002814	putative active site [active]
395965002815	putative metal binding site [ion binding]; other site
395965002816	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395965002817	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
395965002818	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395965002819	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395965002820	protein binding site [polypeptide binding]; other site
395965002821	helicase 45; Provisional; Region: PTZ00424
395965002822	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
395965002823	ATP binding site [chemical binding]; other site
395965002824	Mg++ binding site [ion binding]; other site
395965002825	motif III; other site
395965002826	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395965002827	nucleotide binding region [chemical binding]; other site
395965002828	ATP-binding site [chemical binding]; other site
395965002829	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395965002830	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
395965002831	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_17; cd08356
395965002832	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395965002833	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
395965002834	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
395965002835	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
395965002836	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395965002837	Domain of unknown function DUF20; Region: UPF0118; pfam01594
395965002838	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
395965002839	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
395965002840	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
395965002841	dimerization interface [polypeptide binding]; other site
395965002842	putative ATP binding site [chemical binding]; other site
395965002843	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
395965002844	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
395965002845	active site
395965002846	substrate binding site [chemical binding]; other site
395965002847	cosubstrate binding site; other site
395965002848	catalytic site [active]
395965002849	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
395965002850	conserved cys residue [active]
395965002851	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395965002852	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395965002853	substrate binding pocket [chemical binding]; other site
395965002854	membrane-bound complex binding site; other site
395965002855	hinge residues; other site
395965002856	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
395965002857	active site
395965002858	multimer interface [polypeptide binding]; other site
395965002859	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
395965002860	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965002861	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
395965002862	dimerization interface [polypeptide binding]; other site
395965002863	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
395965002864	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
395965002865	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
395965002866	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
395965002867	dimer interface [polypeptide binding]; other site
395965002868	decamer (pentamer of dimers) interface [polypeptide binding]; other site
395965002869	catalytic triad [active]
395965002870	peroxidatic and resolving cysteines [active]
395965002871	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
395965002872	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395965002873	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395965002874	ABC transporter; Region: ABC_tran_2; pfam12848
395965002875	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395965002876	camphor resistance protein CrcB; Provisional; Region: PRK14206
395965002877	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
395965002878	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
395965002879	dimer interface [polypeptide binding]; other site
395965002880	putative functional site; other site
395965002881	putative MPT binding site; other site
395965002882	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
395965002883	Walker A motif; other site
395965002884	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
395965002885	CPxP  motif; other site
395965002886	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
395965002887	NUDIX domain; Region: NUDIX; pfam00293
395965002888	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395965002889	salicylate hydroxylase; Provisional; Region: PRK08163
395965002890	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
395965002891	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395965002892	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395965002893	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
395965002894	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
395965002895	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395965002896	active site
395965002897	motif I; other site
395965002898	motif II; other site
395965002899	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
395965002900	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
395965002901	putative active site [active]
395965002902	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
395965002903	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
395965002904	catalytic site [active]
395965002905	G-X2-G-X-G-K; other site
395965002906	hypothetical protein; Provisional; Region: PRK11820
395965002907	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
395965002908	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
395965002909	GTPase Era; Reviewed; Region: era; PRK00089
395965002910	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
395965002911	G1 box; other site
395965002912	GTP/Mg2+ binding site [chemical binding]; other site
395965002913	Switch I region; other site
395965002914	G2 box; other site
395965002915	Switch II region; other site
395965002916	G3 box; other site
395965002917	G4 box; other site
395965002918	G5 box; other site
395965002919	KH domain; Region: KH_2; pfam07650
395965002920	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
395965002921	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
395965002922	dimerization interface [polypeptide binding]; other site
395965002923	active site
395965002924	metal binding site [ion binding]; metal-binding site
395965002925	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
395965002926	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
395965002927	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
395965002928	Catalytic site [active]
395965002929	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
395965002930	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
395965002931	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
395965002932	active site
395965002933	hydrophilic channel; other site
395965002934	dimerization interface [polypeptide binding]; other site
395965002935	catalytic residues [active]
395965002936	active site lid [active]
395965002937	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
395965002938	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395965002939	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395965002940	Sel1-like repeats; Region: SEL1; smart00671
395965002941	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
395965002942	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395965002943	Zn2+ binding site [ion binding]; other site
395965002944	Mg2+ binding site [ion binding]; other site
395965002945	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
395965002946	synthetase active site [active]
395965002947	NTP binding site [chemical binding]; other site
395965002948	metal binding site [ion binding]; metal-binding site
395965002949	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
395965002950	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
395965002951	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
395965002952	Uncharacterized conserved protein [Function unknown]; Region: COG1432
395965002953	LabA_like proteins; Region: LabA; cd10911
395965002954	putative metal binding site [ion binding]; other site
395965002955	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
395965002956	Fe-S cluster binding site [ion binding]; other site
395965002957	DNA binding site [nucleotide binding]
395965002958	active site
395965002959	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
395965002960	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
395965002961	acyl-activating enzyme (AAE) consensus motif; other site
395965002962	AMP binding site [chemical binding]; other site
395965002963	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
395965002964	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
395965002965	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
395965002966	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
395965002967	putative trimer interface [polypeptide binding]; other site
395965002968	putative CoA binding site [chemical binding]; other site
395965002969	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
395965002970	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
395965002971	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
395965002972	NAD binding site [chemical binding]; other site
395965002973	homotetramer interface [polypeptide binding]; other site
395965002974	homodimer interface [polypeptide binding]; other site
395965002975	substrate binding site [chemical binding]; other site
395965002976	active site
395965002977	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
395965002978	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
395965002979	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
395965002980	GDP-binding site [chemical binding]; other site
395965002981	ACT binding site; other site
395965002982	IMP binding site; other site
395965002983	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
395965002984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965002985	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
395965002986	putative substrate translocation pore; other site
395965002987	Protein of unknown function (DUF1465); Region: DUF1465; pfam07323
395965002988	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
395965002989	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
395965002990	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
395965002991	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
395965002992	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
395965002993	active site
395965002994	acetylornithine deacetylase; Provisional; Region: PRK07522
395965002995	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
395965002996	metal binding site [ion binding]; metal-binding site
395965002997	putative dimer interface [polypeptide binding]; other site
395965002998	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
395965002999	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
395965003000	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395965003001	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395965003002	catalytic residue [active]
395965003003	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
395965003004	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
395965003005	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
395965003006	trimer interface [polypeptide binding]; other site
395965003007	active site
395965003008	Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717
395965003009	trimer interface [polypeptide binding]; other site
395965003010	active site
395965003011	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
395965003012	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
395965003013	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
395965003014	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
395965003015	metal binding site [ion binding]; metal-binding site
395965003016	dimer interface [polypeptide binding]; other site
395965003017	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
395965003018	tetramerization interface [polypeptide binding]; other site
395965003019	active site
395965003020	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
395965003021	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
395965003022	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395965003023	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965003024	S-adenosylmethionine binding site [chemical binding]; other site
395965003025	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
395965003026	dimer interface [polypeptide binding]; other site
395965003027	substrate binding site [chemical binding]; other site
395965003028	metal binding sites [ion binding]; metal-binding site
395965003029	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
395965003030	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395965003031	Coenzyme A binding pocket [chemical binding]; other site
395965003032	FOG: CBS domain [General function prediction only]; Region: COG0517
395965003033	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
395965003034	BON domain; Region: BON; pfam04972
395965003035	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
395965003036	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
395965003037	hypothetical protein; Provisional; Region: PRK08378
395965003038	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
395965003039	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
395965003040	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395965003041	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395965003042	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
395965003043	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395965003044	non-specific DNA binding site [nucleotide binding]; other site
395965003045	salt bridge; other site
395965003046	sequence-specific DNA binding site [nucleotide binding]; other site
395965003047	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
395965003048	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
395965003049	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
395965003050	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395965003051	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
395965003052	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
395965003053	active site
395965003054	nucleophile elbow; other site
395965003055	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395965003056	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395965003057	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965003058	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395965003059	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
395965003060	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
395965003061	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
395965003062	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
395965003063	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395965003064	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395965003065	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
395965003066	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
395965003067	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395965003068	FeS/SAM binding site; other site
395965003069	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
395965003070	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395965003071	DNA-binding site [nucleotide binding]; DNA binding site
395965003072	RNA-binding motif; other site
395965003073	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
395965003074	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
395965003075	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
395965003076	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395965003077	Domain of unknown function (DUF377); Region: DUF377; pfam04041
395965003078	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
395965003079	active site
395965003080	PAS domain; Region: PAS; smart00091
395965003081	PAS domain; Region: PAS_9; pfam13426
395965003082	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395965003083	Histidine kinase; Region: HisKA_2; pfam07568
395965003084	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965003085	ATP binding site [chemical binding]; other site
395965003086	Mg2+ binding site [ion binding]; other site
395965003087	G-X-G motif; other site
395965003088	Domain of unknown function DUF59; Region: DUF59; pfam01883
395965003089	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
395965003090	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
395965003091	Walker A motif; other site
395965003092	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
395965003093	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395965003094	substrate binding pocket [chemical binding]; other site
395965003095	membrane-bound complex binding site; other site
395965003096	hinge residues; other site
395965003097	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
395965003098	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
395965003099	Predicted membrane protein [Function unknown]; Region: COG2261
395965003100	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
395965003101	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
395965003102	putative active site [active]
395965003103	putative PHP Thumb interface [polypeptide binding]; other site
395965003104	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
395965003105	generic binding surface II; other site
395965003106	generic binding surface I; other site
395965003107	DNA Polymerase Y-family; Region: PolY_like; cd03468
395965003108	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
395965003109	DNA binding site [nucleotide binding]
395965003110	Uncharacterized conserved protein [Function unknown]; Region: COG4544
395965003111	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
395965003112	putative substrate binding pocket [chemical binding]; other site
395965003113	AC domain interface; other site
395965003114	catalytic triad [active]
395965003115	AB domain interface; other site
395965003116	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
395965003117	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
395965003118	nucleophilic elbow; other site
395965003119	catalytic triad; other site
395965003120	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
395965003121	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
395965003122	Active Sites [active]
395965003123	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
395965003124	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965003125	dimer interface [polypeptide binding]; other site
395965003126	conserved gate region; other site
395965003127	putative PBP binding loops; other site
395965003128	ABC-ATPase subunit interface; other site
395965003129	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
395965003130	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965003131	dimer interface [polypeptide binding]; other site
395965003132	conserved gate region; other site
395965003133	putative PBP binding loops; other site
395965003134	ABC-ATPase subunit interface; other site
395965003135	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
395965003136	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
395965003137	Walker A/P-loop; other site
395965003138	ATP binding site [chemical binding]; other site
395965003139	Q-loop/lid; other site
395965003140	ABC transporter signature motif; other site
395965003141	Walker B; other site
395965003142	D-loop; other site
395965003143	H-loop/switch region; other site
395965003144	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
395965003145	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
395965003146	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
395965003147	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
395965003148	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395965003149	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
395965003150	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395965003151	HSP70 interaction site [polypeptide binding]; other site
395965003152	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
395965003153	dimer interface [polypeptide binding]; other site
395965003154	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
395965003155	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
395965003156	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
395965003157	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
395965003158	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
395965003159	nudix motif; other site
395965003160	Protein of unknown function (DUF2385); Region: DUF2385; cl11490
395965003161	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
395965003162	putative active site pocket [active]
395965003163	cleavage site
395965003164	Cytochrome c [Energy production and conversion]; Region: COG3258
395965003165	Cytochrome c; Region: Cytochrom_C; pfam00034
395965003166	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395965003167	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
395965003168	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
395965003169	active site
395965003170	substrate binding site [chemical binding]; other site
395965003171	Mg2+ binding site [ion binding]; other site
395965003172	Domain of unknown function (DUF4409); Region: DUF4409; pfam14365
395965003173	Domain of unknown function (DUF239); Region: DUF239; pfam03080
395965003174	adenylosuccinate lyase; Provisional; Region: PRK07492
395965003175	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
395965003176	tetramer interface [polypeptide binding]; other site
395965003177	active site
395965003178	Serine hydrolase; Region: Ser_hydrolase; pfam06821
395965003179	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395965003180	dihydroorotase; Validated; Region: PRK09060
395965003181	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395965003182	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
395965003183	active site
395965003184	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
395965003185	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
395965003186	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
395965003187	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
395965003188	HD domain; Region: HD_3; cl17350
395965003189	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
395965003190	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
395965003191	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
395965003192	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
395965003193	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
395965003194	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
395965003195	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
395965003196	active site
395965003197	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
395965003198	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
395965003199	dimer interface [polypeptide binding]; other site
395965003200	motif 1; other site
395965003201	active site
395965003202	motif 2; other site
395965003203	motif 3; other site
395965003204	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
395965003205	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965003206	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
395965003207	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
395965003208	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
395965003209	substrate binding pocket [chemical binding]; other site
395965003210	chain length determination region; other site
395965003211	substrate-Mg2+ binding site; other site
395965003212	catalytic residues [active]
395965003213	aspartate-rich region 1; other site
395965003214	active site lid residues [active]
395965003215	aspartate-rich region 2; other site
395965003216	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
395965003217	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
395965003218	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965003219	TPR motif; other site
395965003220	binding surface
395965003221	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
395965003222	binding surface
395965003223	TPR motif; other site
395965003224	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965003225	TPR motif; other site
395965003226	binding surface
395965003227	TPR repeat; Region: TPR_11; pfam13414
395965003228	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965003229	binding surface
395965003230	TPR repeat; Region: TPR_11; pfam13414
395965003231	TPR motif; other site
395965003232	TPR repeat; Region: TPR_11; pfam13414
395965003233	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
395965003234	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
395965003235	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898
395965003236	putative hydrophobic ligand binding site [chemical binding]; other site
395965003237	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395965003238	dimerization interface [polypeptide binding]; other site
395965003239	putative DNA binding site [nucleotide binding]; other site
395965003240	putative Zn2+ binding site [ion binding]; other site
395965003241	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
395965003242	intersubunit interface [polypeptide binding]; other site
395965003243	active site
395965003244	Zn2+ binding site [ion binding]; other site
395965003245	Entner-Doudoroff aldolase; Region: eda; TIGR01182
395965003246	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
395965003247	active site
395965003248	intersubunit interface [polypeptide binding]; other site
395965003249	catalytic residue [active]
395965003250	phosphogluconate dehydratase; Validated; Region: PRK09054
395965003251	6-phosphogluconate dehydratase; Region: edd; TIGR01196
395965003252	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
395965003253	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
395965003254	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
395965003255	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
395965003256	interface (dimer of trimers) [polypeptide binding]; other site
395965003257	Substrate-binding/catalytic site; other site
395965003258	Zn-binding sites [ion binding]; other site
395965003259	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
395965003260	NlpC/P60 family; Region: NLPC_P60; cl17555
395965003261	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
395965003262	active site
395965003263	catalytic residues [active]
395965003264	metal binding site [ion binding]; metal-binding site
395965003265	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
395965003266	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
395965003267	putative active site [active]
395965003268	substrate binding site [chemical binding]; other site
395965003269	putative cosubstrate binding site; other site
395965003270	catalytic site [active]
395965003271	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
395965003272	substrate binding site [chemical binding]; other site
395965003273	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
395965003274	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
395965003275	dimerization interface 3.5A [polypeptide binding]; other site
395965003276	active site
395965003277	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
395965003278	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395965003279	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395965003280	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
395965003281	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
395965003282	Uncharacterized conserved protein [Function unknown]; Region: COG1565
395965003283	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
395965003284	Membrane fusogenic activity; Region: BMFP; pfam04380
395965003285	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
395965003286	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
395965003287	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
395965003288	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965003289	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965003290	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
395965003291	Tim44-like domain; Region: Tim44; pfam04280
395965003292	MltA specific insert domain; Region: MltA; smart00925
395965003293	3D domain; Region: 3D; pfam06725
395965003294	Smr domain; Region: Smr; pfam01713
395965003295	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
395965003296	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
395965003297	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
395965003298	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
395965003299	substrate binding site [chemical binding]; other site
395965003300	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
395965003301	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
395965003302	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
395965003303	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
395965003304	coenzyme PQQ biosynthesis enzyme PqqE; Region: PQQ_syn_pqqE; TIGR02109
395965003305	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395965003306	FeS/SAM binding site; other site
395965003307	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
395965003308	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
395965003309	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
395965003310	dimer interface [polypeptide binding]; other site
395965003311	PYR/PP interface [polypeptide binding]; other site
395965003312	TPP binding site [chemical binding]; other site
395965003313	substrate binding site [chemical binding]; other site
395965003314	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
395965003315	TPP-binding site [chemical binding]; other site
395965003316	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
395965003317	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
395965003318	active site
395965003319	ribulose/triose binding site [chemical binding]; other site
395965003320	phosphate binding site [ion binding]; other site
395965003321	substrate (anthranilate) binding pocket [chemical binding]; other site
395965003322	product (indole) binding pocket [chemical binding]; other site
395965003323	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
395965003324	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
395965003325	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395965003326	Coenzyme A binding pocket [chemical binding]; other site
395965003327	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
395965003328	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
395965003329	active site
395965003330	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395965003331	dimer interface [polypeptide binding]; other site
395965003332	catalytic residues [active]
395965003333	substrate binding site [chemical binding]; other site
395965003334	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
395965003335	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
395965003336	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
395965003337	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395965003338	Coenzyme A binding pocket [chemical binding]; other site
395965003339	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395965003340	Creatinine amidohydrolase; Region: Creatininase; pfam02633
395965003341	NMT1/THI5 like; Region: NMT1; pfam09084
395965003342	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395965003343	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395965003344	Walker A/P-loop; other site
395965003345	ATP binding site [chemical binding]; other site
395965003346	Q-loop/lid; other site
395965003347	ABC transporter signature motif; other site
395965003348	Walker B; other site
395965003349	D-loop; other site
395965003350	H-loop/switch region; other site
395965003351	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395965003352	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
395965003353	adenosine kinase; Provisional; Region: PTZ00247
395965003354	substrate binding site [chemical binding]; other site
395965003355	ATP binding site [chemical binding]; other site
395965003356	Fic family protein [Function unknown]; Region: COG3177
395965003357	Fic/DOC family; Region: Fic; pfam02661
395965003358	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
395965003359	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
395965003360	substrate-cofactor binding pocket; other site
395965003361	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965003362	catalytic residue [active]
395965003363	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395965003364	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
395965003365	putative NAD(P) binding site [chemical binding]; other site
395965003366	active site
395965003367	putative substrate binding site [chemical binding]; other site
395965003368	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
395965003369	Predicted membrane protein [Function unknown]; Region: COG3174
395965003370	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
395965003371	GTP-binding protein LepA; Provisional; Region: PRK05433
395965003372	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
395965003373	G1 box; other site
395965003374	putative GEF interaction site [polypeptide binding]; other site
395965003375	GTP/Mg2+ binding site [chemical binding]; other site
395965003376	Switch I region; other site
395965003377	G2 box; other site
395965003378	G3 box; other site
395965003379	Switch II region; other site
395965003380	G4 box; other site
395965003381	G5 box; other site
395965003382	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
395965003383	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
395965003384	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
395965003385	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395965003386	Sel1-like repeats; Region: SEL1; smart00671
395965003387	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
395965003388	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395965003389	active site
395965003390	DNA binding site [nucleotide binding]
395965003391	Int/Topo IB signature motif; other site
395965003392	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
395965003393	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
395965003394	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
395965003395	ATP binding site [chemical binding]; other site
395965003396	active site
395965003397	substrate binding site [chemical binding]; other site
395965003398	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
395965003399	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
395965003400	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
395965003401	putative active site [active]
395965003402	catalytic triad [active]
395965003403	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
395965003404	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
395965003405	dimerization interface [polypeptide binding]; other site
395965003406	ATP binding site [chemical binding]; other site
395965003407	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
395965003408	dimerization interface [polypeptide binding]; other site
395965003409	ATP binding site [chemical binding]; other site
395965003410	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
395965003411	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
395965003412	putative GSH binding site [chemical binding]; other site
395965003413	catalytic residues [active]
395965003414	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
395965003415	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395965003416	catalytic residues [active]
395965003417	argininosuccinate lyase; Provisional; Region: PRK00855
395965003418	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
395965003419	active sites [active]
395965003420	tetramer interface [polypeptide binding]; other site
395965003421	putative hydrolase; Provisional; Region: PRK11460
395965003422	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395965003423	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965003424	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
395965003425	putative dimerization interface [polypeptide binding]; other site
395965003426	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
395965003427	metal binding site [ion binding]; metal-binding site
395965003428	active site
395965003429	phosphoribulokinase; Provisional; Region: PRK15453
395965003430	active site
395965003431	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
395965003432	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
395965003433	TPP-binding site [chemical binding]; other site
395965003434	dimer interface [polypeptide binding]; other site
395965003435	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
395965003436	PYR/PP interface [polypeptide binding]; other site
395965003437	dimer interface [polypeptide binding]; other site
395965003438	TPP binding site [chemical binding]; other site
395965003439	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395965003440	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
395965003441	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
395965003442	intersubunit interface [polypeptide binding]; other site
395965003443	active site
395965003444	zinc binding site [ion binding]; other site
395965003445	Na+ binding site [ion binding]; other site
395965003446	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
395965003447	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
395965003448	homodimer interface [polypeptide binding]; other site
395965003449	active site
395965003450	heterodimer interface [polypeptide binding]; other site
395965003451	catalytic residue [active]
395965003452	metal binding site [ion binding]; metal-binding site
395965003453	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
395965003454	multimerization interface [polypeptide binding]; other site
395965003455	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
395965003456	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965003457	Walker A motif; other site
395965003458	ATP binding site [chemical binding]; other site
395965003459	Walker B motif; other site
395965003460	arginine finger; other site
395965003461	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
395965003462	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
395965003463	substrate binding site [chemical binding]; other site
395965003464	hexamer interface [polypeptide binding]; other site
395965003465	metal binding site [ion binding]; metal-binding site
395965003466	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
395965003467	Ribonuclease P; Region: Ribonuclease_P; cl00457
395965003468	membrane protein insertase; Provisional; Region: PRK01318
395965003469	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
395965003470	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
395965003471	G1 box; other site
395965003472	GTP/Mg2+ binding site [chemical binding]; other site
395965003473	Switch I region; other site
395965003474	G2 box; other site
395965003475	G3 box; other site
395965003476	Switch II region; other site
395965003477	G4 box; other site
395965003478	G5 box; other site
395965003479	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
395965003480	feedback inhibition sensing region; other site
395965003481	homohexameric interface [polypeptide binding]; other site
395965003482	nucleotide binding site [chemical binding]; other site
395965003483	N-acetyl-L-glutamate binding site [chemical binding]; other site
395965003484	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
395965003485	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
395965003486	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
395965003487	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
395965003488	trimer interface [polypeptide binding]; other site
395965003489	active site
395965003490	substrate binding site [chemical binding]; other site
395965003491	CoA binding site [chemical binding]; other site
395965003492	hypothetical protein; Provisional; Region: PRK06034
395965003493	Chorismate mutase type II; Region: CM_2; pfam01817
395965003494	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
395965003495	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395965003496	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965003497	homodimer interface [polypeptide binding]; other site
395965003498	catalytic residue [active]
395965003499	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
395965003500	prephenate dehydrogenase; Validated; Region: PRK08507
395965003501	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
395965003502	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
395965003503	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395965003504	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
395965003505	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
395965003506	tetramer interface [polypeptide binding]; other site
395965003507	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965003508	catalytic residue [active]
395965003509	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
395965003510	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
395965003511	tetramer interface [polypeptide binding]; other site
395965003512	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965003513	catalytic residue [active]
395965003514	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
395965003515	lipoyl attachment site [posttranslational modification]; other site
395965003516	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
395965003517	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
395965003518	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395965003519	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395965003520	active site
395965003521	short chain dehydrogenase; Provisional; Region: PRK07024
395965003522	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395965003523	NAD(P) binding site [chemical binding]; other site
395965003524	active site
395965003525	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
395965003526	active site
395965003527	catalytic site [active]
395965003528	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
395965003529	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
395965003530	dimer interface [polypeptide binding]; other site
395965003531	active site
395965003532	Phosphopantetheine attachment site; Region: PP-binding; cl09936
395965003533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395965003534	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395965003535	acetyl-CoA synthetase; Provisional; Region: PRK00174
395965003536	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
395965003537	active site
395965003538	CoA binding site [chemical binding]; other site
395965003539	acyl-activating enzyme (AAE) consensus motif; other site
395965003540	AMP binding site [chemical binding]; other site
395965003541	acetate binding site [chemical binding]; other site
395965003542	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
395965003543	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
395965003544	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
395965003545	Repair protein; Region: Repair_PSII; pfam04536
395965003546	Repair protein; Region: Repair_PSII; cl01535
395965003547	Repair protein; Region: Repair_PSII; cl01535
395965003548	Transglycosylase SLT domain; Region: SLT_2; pfam13406
395965003549	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395965003550	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395965003551	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
395965003552	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395965003553	Response regulator receiver domain; Region: Response_reg; pfam00072
395965003554	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965003555	active site
395965003556	phosphorylation site [posttranslational modification]
395965003557	intermolecular recognition site; other site
395965003558	dimerization interface [polypeptide binding]; other site
395965003559	N-formylglutamate amidohydrolase; Region: FGase; cl01522
395965003560	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
395965003561	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
395965003562	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
395965003563	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
395965003564	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
395965003565	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
395965003566	Subunit I/III interface [polypeptide binding]; other site
395965003567	D-pathway; other site
395965003568	Subunit I/VIIc interface [polypeptide binding]; other site
395965003569	Subunit I/IV interface [polypeptide binding]; other site
395965003570	Subunit I/II interface [polypeptide binding]; other site
395965003571	Low-spin heme (heme a) binding site [chemical binding]; other site
395965003572	Subunit I/VIIa interface [polypeptide binding]; other site
395965003573	Subunit I/VIa interface [polypeptide binding]; other site
395965003574	Dimer interface; other site
395965003575	Putative water exit pathway; other site
395965003576	Binuclear center (heme a3/CuB) [ion binding]; other site
395965003577	K-pathway; other site
395965003578	Subunit I/Vb interface [polypeptide binding]; other site
395965003579	Putative proton exit pathway; other site
395965003580	Subunit I/VIb interface; other site
395965003581	Subunit I/VIc interface [polypeptide binding]; other site
395965003582	Electron transfer pathway; other site
395965003583	Subunit I/VIIIb interface [polypeptide binding]; other site
395965003584	Subunit I/VIIb interface [polypeptide binding]; other site
395965003585	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
395965003586	UbiA prenyltransferase family; Region: UbiA; pfam01040
395965003587	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
395965003588	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
395965003589	Subunit III/VIIa interface [polypeptide binding]; other site
395965003590	Phospholipid binding site [chemical binding]; other site
395965003591	Subunit I/III interface [polypeptide binding]; other site
395965003592	Subunit III/VIb interface [polypeptide binding]; other site
395965003593	Subunit III/VIa interface; other site
395965003594	Subunit III/Vb interface [polypeptide binding]; other site
395965003595	Cupin domain; Region: Cupin_2; pfam07883
395965003596	Ribulose bisphosphate carboxylase like proteins (RLPs) similar to R.rubrum RLP; Region: RLP_RrRLP; cd08210
395965003597	dimer interface [polypeptide binding]; other site
395965003598	active site
395965003599	catalytic residue [active]
395965003600	metal binding site [ion binding]; metal-binding site
395965003601	Condensation domain; Region: Condensation; pfam00668
395965003602	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
395965003603	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
395965003604	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
395965003605	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
395965003606	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
395965003607	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
395965003608	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
395965003609	active site
395965003610	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
395965003611	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
395965003612	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
395965003613	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
395965003614	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395965003615	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395965003616	catalytic residue [active]
395965003617	Condensation domain; Region: Condensation; pfam00668
395965003618	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
395965003619	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
395965003620	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
395965003621	acyl-activating enzyme (AAE) consensus motif; other site
395965003622	AMP binding site [chemical binding]; other site
395965003623	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
395965003624	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
395965003625	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
395965003626	acyl-activating enzyme (AAE) consensus motif; other site
395965003627	AMP binding site [chemical binding]; other site
395965003628	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
395965003629	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
395965003630	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
395965003631	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
395965003632	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
395965003633	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965003634	catalytic residue [active]
395965003635	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
395965003636	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
395965003637	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
395965003638	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
395965003639	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
395965003640	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
395965003641	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
395965003642	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395965003643	PAS fold; Region: PAS_3; pfam08447
395965003644	putative active site [active]
395965003645	heme pocket [chemical binding]; other site
395965003646	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395965003647	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395965003648	metal binding site [ion binding]; metal-binding site
395965003649	active site
395965003650	I-site; other site
395965003651	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395965003652	hypothetical protein; Validated; Region: PRK00228
395965003653	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
395965003654	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
395965003655	catalytic triad [active]
395965003656	dimer interface [polypeptide binding]; other site
395965003657	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
395965003658	RNA/DNA hybrid binding site [nucleotide binding]; other site
395965003659	active site
395965003660	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
395965003661	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
395965003662	putative active site [active]
395965003663	putative substrate binding site [chemical binding]; other site
395965003664	ATP binding site [chemical binding]; other site
395965003665	Uncharacterized conserved protein [Function unknown]; Region: COG2928
395965003666	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395965003667	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
395965003668	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395965003669	Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
395965003670	dimerization interface [polypeptide binding]; other site
395965003671	putative path to active site cavity [active]
395965003672	diiron center [ion binding]; other site
395965003673	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
395965003674	dimerization interface [polypeptide binding]; other site
395965003675	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
395965003676	Methane monooxygenase, hydrolase gamma chain; Region: MeMO_Hyd_G; pfam02964
395965003677	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
395965003678	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395965003679	catalytic loop [active]
395965003680	iron binding site [ion binding]; other site
395965003681	Methane monooxygenase (MMO) reductase of methanotrophs catalyzes the NADH-dependent hydroxylation of methane to methanol. This multicomponent enzyme mediates electron transfer via a hydroxylase (MMOH), a coupling protein, and a reductase which is...; Region: MMO_FAD_NAD_binding; cd06210
395965003682	FAD binding pocket [chemical binding]; other site
395965003683	FAD binding motif [chemical binding]; other site
395965003684	phosphate binding motif [ion binding]; other site
395965003685	beta-alpha-beta structure motif; other site
395965003686	NAD binding pocket [chemical binding]; other site
395965003687	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
395965003688	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965003689	Walker A motif; other site
395965003690	ATP binding site [chemical binding]; other site
395965003691	Walker B motif; other site
395965003692	arginine finger; other site
395965003693	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395965003694	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
395965003695	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
395965003696	ring oligomerisation interface [polypeptide binding]; other site
395965003697	ATP/Mg binding site [chemical binding]; other site
395965003698	stacking interactions; other site
395965003699	hinge regions; other site
395965003700	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
395965003701	metal binding site 2 [ion binding]; metal-binding site
395965003702	putative DNA binding helix; other site
395965003703	metal binding site 1 [ion binding]; metal-binding site
395965003704	dimer interface [polypeptide binding]; other site
395965003705	Cytochrome c; Region: Cytochrom_C; cl11414
395965003706	Cytochrome c; Region: Cytochrom_C; pfam00034
395965003707	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
395965003708	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
395965003709	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
395965003710	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395965003711	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395965003712	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
395965003713	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
395965003714	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
395965003715	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
395965003716	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
395965003717	active site
395965003718	catalytic residues [active]
395965003719	DNA binding site [nucleotide binding]
395965003720	Int/Topo IB signature motif; other site
395965003721	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
395965003722	HTH-like domain; Region: HTH_21; pfam13276
395965003723	Integrase core domain; Region: rve; pfam00665
395965003724	Integrase core domain; Region: rve_3; pfam13683
395965003725	Transposase; Region: HTH_Tnp_1; cl17663
395965003726	TIGR03118 family protein; Region: PEPCTERM_chp_1
395965003727	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395965003728	Carboxylesterase family; Region: COesterase; pfam00135
395965003729	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
395965003730	substrate binding pocket [chemical binding]; other site
395965003731	catalytic triad [active]
395965003732	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-2; cd12809
395965003733	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395965003734	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395965003735	catalytic site [active]
395965003736	PRC-barrel domain; Region: PRC; pfam05239
395965003737	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965003738	putative substrate translocation pore; other site
395965003739	patatin-related protein; Region: TIGR03607
395965003740	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
395965003741	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
395965003742	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395965003743	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
395965003744	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
395965003745	DNA binding site [nucleotide binding]
395965003746	active site
395965003747	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
395965003748	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
395965003749	putative active site [active]
395965003750	Zn binding site [ion binding]; other site
395965003751	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
395965003752	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
395965003753	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
395965003754	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
395965003755	putative PBP binding regions; other site
395965003756	ABC-ATPase subunit  interface; other site
395965003757	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
395965003758	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
395965003759	intersubunit interface [polypeptide binding]; other site
395965003760	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
395965003761	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
395965003762	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
395965003763	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395965003764	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
395965003765	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395965003766	motif II; other site
395965003767	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
395965003768	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
395965003769	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395965003770	active site
395965003771	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
395965003772	FMN binding site [chemical binding]; other site
395965003773	substrate binding site [chemical binding]; other site
395965003774	putative catalytic residue [active]
395965003775	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
395965003776	PLD-like domain; Region: PLDc_2; pfam13091
395965003777	putative active site [active]
395965003778	catalytic site [active]
395965003779	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
395965003780	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
395965003781	Ion channel; Region: Ion_trans_2; pfam07885
395965003782	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
395965003783	TrkA-N domain; Region: TrkA_N; pfam02254
395965003784	Protein of unknown function (DUF779); Region: DUF779; pfam05610
395965003785	malate synthase G; Provisional; Region: PRK02999
395965003786	active site
395965003787	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
395965003788	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
395965003789	MAPEG family; Region: MAPEG; cl09190
395965003790	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
395965003791	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
395965003792	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
395965003793	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
395965003794	active site
395965003795	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965003796	putative transporter; Provisional; Region: PRK10504
395965003797	putative substrate translocation pore; other site
395965003798	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
395965003799	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965003800	S-adenosylmethionine binding site [chemical binding]; other site
395965003801	exopolyphosphatase; Region: exo_poly_only; TIGR03706
395965003802	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
395965003803	Caspase domain; Region: Peptidase_C14; pfam00656
395965003804	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
395965003805	putative uracil binding site [chemical binding]; other site
395965003806	putative active site [active]
395965003807	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
395965003808	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
395965003809	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395965003810	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965003811	dimer interface [polypeptide binding]; other site
395965003812	phosphorylation site [posttranslational modification]
395965003813	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965003814	ATP binding site [chemical binding]; other site
395965003815	Mg2+ binding site [ion binding]; other site
395965003816	G-X-G motif; other site
395965003817	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
395965003818	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
395965003819	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
395965003820	cofactor binding site; other site
395965003821	DNA binding site [nucleotide binding]
395965003822	substrate interaction site [chemical binding]; other site
395965003823	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
395965003824	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
395965003825	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
395965003826	putative dimer interface [polypeptide binding]; other site
395965003827	active site pocket [active]
395965003828	putative cataytic base [active]
395965003829	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
395965003830	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
395965003831	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
395965003832	Peptidase family M23; Region: Peptidase_M23; pfam01551
395965003833	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
395965003834	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395965003835	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
395965003836	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965003837	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965003838	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
395965003839	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
395965003840	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
395965003841	homotrimer interaction site [polypeptide binding]; other site
395965003842	putative active site [active]
395965003843	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
395965003844	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
395965003845	active site
395965003846	catalytic site [active]
395965003847	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
395965003848	active site
395965003849	substrate binding sites [chemical binding]; other site
395965003850	sphingolipid delta-4 desaturase; Region: PLN02579
395965003851	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
395965003852	putative di-iron ligands [ion binding]; other site
395965003853	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
395965003854	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
395965003855	substrate-cofactor binding pocket; other site
395965003856	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965003857	catalytic residue [active]
395965003858	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
395965003859	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
395965003860	pyruvate carboxylase; Reviewed; Region: PRK12999
395965003861	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395965003862	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
395965003863	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
395965003864	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
395965003865	active site
395965003866	catalytic residues [active]
395965003867	metal binding site [ion binding]; metal-binding site
395965003868	homodimer binding site [polypeptide binding]; other site
395965003869	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
395965003870	carboxyltransferase (CT) interaction site; other site
395965003871	biotinylation site [posttranslational modification]; other site
395965003872	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
395965003873	Peptidase family M48; Region: Peptidase_M48; cl12018
395965003874	carbon starvation protein A; Provisional; Region: PRK15015
395965003875	Carbon starvation protein CstA; Region: CstA; pfam02554
395965003876	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
395965003877	Protein of unknown function (DUF466); Region: DUF466; pfam04328
395965003878	hypothetical protein; Provisional; Region: PRK06185
395965003879	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395965003880	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
395965003881	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
395965003882	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
395965003883	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395965003884	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
395965003885	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395965003886	RNA binding surface [nucleotide binding]; other site
395965003887	Ferredoxin [Energy production and conversion]; Region: COG1146
395965003888	4Fe-4S binding domain; Region: Fer4; cl02805
395965003889	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
395965003890	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
395965003891	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
395965003892	alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175
395965003893	Uncharacterized small protein [Function unknown]; Region: COG5568
395965003894	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
395965003895	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
395965003896	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
395965003897	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
395965003898	active site
395965003899	substrate-binding site [chemical binding]; other site
395965003900	metal-binding site [ion binding]
395965003901	ATP binding site [chemical binding]; other site
395965003902	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
395965003903	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
395965003904	ligand binding site [chemical binding]; other site
395965003905	NAD binding site [chemical binding]; other site
395965003906	dimerization interface [polypeptide binding]; other site
395965003907	catalytic site [active]
395965003908	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
395965003909	putative L-serine binding site [chemical binding]; other site
395965003910	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
395965003911	Cupin; Region: Cupin_6; pfam12852
395965003912	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395965003913	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395965003914	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395965003915	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395965003916	MarR family; Region: MarR_2; pfam12802
395965003917	hypothetical protein; Provisional; Region: PRK07236
395965003918	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
395965003919	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
395965003920	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395965003921	catalytic residue [active]
395965003922	argininosuccinate synthase; Provisional; Region: PRK13820
395965003923	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
395965003924	ANP binding site [chemical binding]; other site
395965003925	Substrate Binding Site II [chemical binding]; other site
395965003926	Substrate Binding Site I [chemical binding]; other site
395965003927	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
395965003928	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
395965003929	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
395965003930	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
395965003931	putative active site [active]
395965003932	PAS fold; Region: PAS_4; pfam08448
395965003933	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395965003934	putative active site [active]
395965003935	heme pocket [chemical binding]; other site
395965003936	PAS fold; Region: PAS_4; pfam08448
395965003937	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395965003938	HWE histidine kinase; Region: HWE_HK; pfam07536
395965003939	5'-3' exonuclease; Region: 53EXOc; smart00475
395965003940	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
395965003941	active site
395965003942	metal binding site 1 [ion binding]; metal-binding site
395965003943	putative 5' ssDNA interaction site; other site
395965003944	metal binding site 3; metal-binding site
395965003945	metal binding site 2 [ion binding]; metal-binding site
395965003946	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
395965003947	putative DNA binding site [nucleotide binding]; other site
395965003948	putative metal binding site [ion binding]; other site
395965003949	DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749
395965003950	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
395965003951	active site
395965003952	catalytic site [active]
395965003953	substrate binding site [chemical binding]; other site
395965003954	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
395965003955	active site
395965003956	DNA binding site [nucleotide binding]
395965003957	catalytic site [active]
395965003958	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
395965003959	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
395965003960	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
395965003961	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395965003962	substrate binding site [chemical binding]; other site
395965003963	oxyanion hole (OAH) forming residues; other site
395965003964	trimer interface [polypeptide binding]; other site
395965003965	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
395965003966	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
395965003967	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
395965003968	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
395965003969	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395965003970	Walker A/P-loop; other site
395965003971	ATP binding site [chemical binding]; other site
395965003972	Q-loop/lid; other site
395965003973	ABC transporter signature motif; other site
395965003974	Walker B; other site
395965003975	D-loop; other site
395965003976	H-loop/switch region; other site
395965003977	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395965003978	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395965003979	Walker A/P-loop; other site
395965003980	ATP binding site [chemical binding]; other site
395965003981	Q-loop/lid; other site
395965003982	ABC transporter signature motif; other site
395965003983	Walker B; other site
395965003984	D-loop; other site
395965003985	H-loop/switch region; other site
395965003986	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395965003987	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965003988	dimer interface [polypeptide binding]; other site
395965003989	conserved gate region; other site
395965003990	putative PBP binding loops; other site
395965003991	ABC-ATPase subunit interface; other site
395965003992	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
395965003993	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965003994	dimer interface [polypeptide binding]; other site
395965003995	conserved gate region; other site
395965003996	putative PBP binding loops; other site
395965003997	ABC-ATPase subunit interface; other site
395965003998	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
395965003999	oligomeric interface; other site
395965004000	putative active site [active]
395965004001	homodimer interface [polypeptide binding]; other site
395965004002	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
395965004003	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
395965004004	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
395965004005	substrate binding site [chemical binding]; other site
395965004006	active site
395965004007	catalytic residues [active]
395965004008	heterodimer interface [polypeptide binding]; other site
395965004009	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
395965004010	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
395965004011	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
395965004012	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395965004013	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
395965004014	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
395965004015	Cytochrome c; Region: Cytochrom_C; pfam00034
395965004016	glutaminase; Reviewed; Region: PRK12356
395965004017	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
395965004018	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395965004019	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
395965004020	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395965004021	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
395965004022	active site
395965004023	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
395965004024	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395965004025	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
395965004026	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395965004027	catalytic residues [active]
395965004028	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
395965004029	Family description; Region: UvrD_C_2; pfam13538
395965004030	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
395965004031	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
395965004032	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
395965004033	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395965004034	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
395965004035	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
395965004036	thiS-thiF/thiG interaction site; other site
395965004037	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
395965004038	ThiS interaction site; other site
395965004039	putative active site [active]
395965004040	tetramer interface [polypeptide binding]; other site
395965004041	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
395965004042	active site
395965004043	thiamine phosphate binding site [chemical binding]; other site
395965004044	pyrophosphate binding site [ion binding]; other site
395965004045	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395965004046	DNA binding site [nucleotide binding]
395965004047	Predicted integral membrane protein [Function unknown]; Region: COG5616
395965004048	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965004049	TPR motif; other site
395965004050	binding surface
395965004051	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965004052	TPR motif; other site
395965004053	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
395965004054	active site 1 [active]
395965004055	dimer interface [polypeptide binding]; other site
395965004056	hexamer interface [polypeptide binding]; other site
395965004057	active site 2 [active]
395965004058	muropeptide transporter; Reviewed; Region: ampG; PRK11902
395965004059	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965004060	putative substrate translocation pore; other site
395965004061	Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600
395965004062	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
395965004063	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
395965004064	putative RNA binding site [nucleotide binding]; other site
395965004065	16S rRNA methyltransferase B; Provisional; Region: PRK10901
395965004066	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
395965004067	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
395965004068	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
395965004069	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
395965004070	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
395965004071	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
395965004072	dimer interface [polypeptide binding]; other site
395965004073	motif 1; other site
395965004074	active site
395965004075	motif 2; other site
395965004076	motif 3; other site
395965004077	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
395965004078	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
395965004079	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
395965004080	active site
395965004081	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
395965004082	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
395965004083	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
395965004084	hinge; other site
395965004085	active site
395965004086	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
395965004087	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395965004088	FeS/SAM binding site; other site
395965004089	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
395965004090	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
395965004091	GIY-YIG motif/motif A; other site
395965004092	active site
395965004093	catalytic site [active]
395965004094	putative DNA binding site [nucleotide binding]; other site
395965004095	metal binding site [ion binding]; metal-binding site
395965004096	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
395965004097	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
395965004098	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
395965004099	MoaE interaction surface [polypeptide binding]; other site
395965004100	MoeB interaction surface [polypeptide binding]; other site
395965004101	thiocarboxylated glycine; other site
395965004102	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
395965004103	MoaE homodimer interface [polypeptide binding]; other site
395965004104	MoaD interaction [polypeptide binding]; other site
395965004105	active site residues [active]
395965004106	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
395965004107	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965004108	putative substrate translocation pore; other site
395965004109	CheD chemotactic sensory transduction; Region: CheD; cl00810
395965004110	Response regulator receiver domain; Region: Response_reg; pfam00072
395965004111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965004112	active site
395965004113	phosphorylation site [posttranslational modification]
395965004114	intermolecular recognition site; other site
395965004115	dimerization interface [polypeptide binding]; other site
395965004116	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
395965004117	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965004118	active site
395965004119	phosphorylation site [posttranslational modification]
395965004120	intermolecular recognition site; other site
395965004121	dimerization interface [polypeptide binding]; other site
395965004122	CheB methylesterase; Region: CheB_methylest; pfam01339
395965004123	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
395965004124	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
395965004125	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
395965004126	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
395965004127	putative CheA interaction surface; other site
395965004128	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
395965004129	putative binding surface; other site
395965004130	active site
395965004131	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
395965004132	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
395965004133	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965004134	ATP binding site [chemical binding]; other site
395965004135	Mg2+ binding site [ion binding]; other site
395965004136	G-X-G motif; other site
395965004137	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
395965004138	Response regulator receiver domain; Region: Response_reg; pfam00072
395965004139	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965004140	active site
395965004141	phosphorylation site [posttranslational modification]
395965004142	intermolecular recognition site; other site
395965004143	dimerization interface [polypeptide binding]; other site
395965004144	STAS domain; Region: STAS_2; pfam13466
395965004145	HAMP domain; Region: HAMP; pfam00672
395965004146	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
395965004147	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
395965004148	dimer interface [polypeptide binding]; other site
395965004149	putative CheW interface [polypeptide binding]; other site
395965004150	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395965004151	Ligand Binding Site [chemical binding]; other site
395965004152	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
395965004153	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
395965004154	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
395965004155	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965004156	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965004157	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965004158	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965004159	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
395965004160	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
395965004161	Transcriptional regulator [Transcription]; Region: IclR; COG1414
395965004162	Bacterial transcriptional regulator; Region: IclR; pfam01614
395965004163	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
395965004164	FAD binding domain; Region: FAD_binding_3; pfam01494
395965004165	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
395965004166	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
395965004167	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
395965004168	metal binding site [ion binding]; metal-binding site
395965004169	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
395965004170	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
395965004171	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
395965004172	active site
395965004173	Fe binding site [ion binding]; other site
395965004174	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
395965004175	[2Fe-2S] cluster binding site [ion binding]; other site
395965004176	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
395965004177	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
395965004178	iron-sulfur cluster [ion binding]; other site
395965004179	[2Fe-2S] cluster binding site [ion binding]; other site
395965004180	C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880
395965004181	putative alpha subunit interface [polypeptide binding]; other site
395965004182	putative active site [active]
395965004183	putative substrate binding site [chemical binding]; other site
395965004184	Fe binding site [ion binding]; other site
395965004185	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
395965004186	inter-subunit interface; other site
395965004187	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
395965004188	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395965004189	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395965004190	Helix-turn-helix domain; Region: HTH_18; pfam12833
395965004191	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
395965004192	catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
395965004193	N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265
395965004194	tetramer interface [polypeptide binding]; other site
395965004195	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
395965004196	active site
395965004197	metal binding site [ion binding]; metal-binding site
395965004198	Domain of unknown function (DUF336); Region: DUF336; pfam03928
395965004199	2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216
395965004200	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
395965004201	NAD binding site [chemical binding]; other site
395965004202	catalytic residues [active]
395965004203	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
395965004204	acetaldehyde dehydrogenase; Validated; Region: PRK08300
395965004205	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
395965004206	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
395965004207	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
395965004208	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
395965004209	active site
395965004210	catalytic residues [active]
395965004211	metal binding site [ion binding]; metal-binding site
395965004212	DmpG-like communication domain; Region: DmpG_comm; pfam07836
395965004213	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
395965004214	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
395965004215	active site 1 [active]
395965004216	dimer interface [polypeptide binding]; other site
395965004217	hexamer interface [polypeptide binding]; other site
395965004218	active site 2 [active]
395965004219	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
395965004220	conjugal transfer protein TrbF; Provisional; Region: PRK13872
395965004221	conjugal transfer protein TrbL; Provisional; Region: PRK13875
395965004222	transposase/IS protein; Provisional; Region: PRK09183
395965004223	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
395965004224	CHAT domain; Region: CHAT; pfam12770
395965004225	HTH-like domain; Region: HTH_21; pfam13276
395965004226	Integrase core domain; Region: rve; pfam00665
395965004227	Transposase; Region: HTH_Tnp_1; pfam01527
395965004228	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
395965004229	Isochorismatase family; Region: Isochorismatase; pfam00857
395965004230	catalytic triad [active]
395965004231	dimer interface [polypeptide binding]; other site
395965004232	conserved cis-peptide bond; other site
395965004233	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
395965004234	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395965004235	active site
395965004236	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
395965004237	Predicted acetyltransferase [General function prediction only]; Region: COG2388
395965004238	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
395965004239	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
395965004240	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
395965004241	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
395965004242	4Fe-4S binding domain; Region: Fer4; cl02805
395965004243	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
395965004244	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
395965004245	[4Fe-4S] binding site [ion binding]; other site
395965004246	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
395965004247	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
395965004248	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
395965004249	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
395965004250	molybdopterin cofactor binding site; other site
395965004251	transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392
395965004252	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395965004253	ligand binding site [chemical binding]; other site
395965004254	flexible hinge region; other site
395965004255	putative switch regulator; other site
395965004256	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
395965004257	non-specific DNA interactions [nucleotide binding]; other site
395965004258	DNA binding site [nucleotide binding]
395965004259	sequence specific DNA binding site [nucleotide binding]; other site
395965004260	putative cAMP binding site [chemical binding]; other site
395965004261	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
395965004262	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965004263	putative substrate translocation pore; other site
395965004264	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
395965004265	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
395965004266	Subunit I/III interface [polypeptide binding]; other site
395965004267	Cytochrome c; Region: Cytochrom_C; pfam00034
395965004268	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
395965004269	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
395965004270	D-pathway; other site
395965004271	Low-spin heme binding site [chemical binding]; other site
395965004272	K-pathway; other site
395965004273	Binuclear center (active site) [active]
395965004274	Putative proton exit pathway; other site
395965004275	Putative water exit pathway; other site
395965004276	MoxR-like ATPases [General function prediction only]; Region: COG0714
395965004277	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965004278	Walker A motif; other site
395965004279	ATP binding site [chemical binding]; other site
395965004280	Walker B motif; other site
395965004281	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
395965004282	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
395965004283	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
395965004284	metal ion-dependent adhesion site (MIDAS); other site
395965004285	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
395965004286	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
395965004287	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
395965004288	Cytochrome c; Region: Cytochrom_C; pfam00034
395965004289	Uncharacterized conserved protein [Function unknown]; Region: COG1262
395965004290	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
395965004291	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
395965004292	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
395965004293	Cu(I) binding site [ion binding]; other site
395965004294	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
395965004295	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395965004296	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395965004297	ligand binding site [chemical binding]; other site
395965004298	flexible hinge region; other site
395965004299	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
395965004300	putative switch regulator; other site
395965004301	non-specific DNA interactions [nucleotide binding]; other site
395965004302	DNA binding site [nucleotide binding]
395965004303	sequence specific DNA binding site [nucleotide binding]; other site
395965004304	putative cAMP binding site [chemical binding]; other site
395965004305	NnrS protein; Region: NnrS; pfam05940
395965004306	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395965004307	HAMP domain; Region: HAMP; pfam00672
395965004308	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965004309	dimer interface [polypeptide binding]; other site
395965004310	phosphorylation site [posttranslational modification]
395965004311	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965004312	ATP binding site [chemical binding]; other site
395965004313	Mg2+ binding site [ion binding]; other site
395965004314	G-X-G motif; other site
395965004315	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395965004316	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395965004317	DNA binding site [nucleotide binding]
395965004318	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
395965004319	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
395965004320	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395965004321	non-specific DNA binding site [nucleotide binding]; other site
395965004322	salt bridge; other site
395965004323	sequence-specific DNA binding site [nucleotide binding]; other site
395965004324	Helix-turn-helix domain; Region: HTH_17; pfam12728
395965004325	CHC2 zinc finger; Region: zf-CHC2; cl17510
395965004326	hypothetical protein; Validated; Region: PRK07078
395965004327	PrkA AAA domain; Region: AAA_PrkA; smart00763
395965004328	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
395965004329	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
395965004330	MarR family; Region: MarR_2; pfam12802
395965004331	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
395965004332	tandem repeat interface [polypeptide binding]; other site
395965004333	oligomer interface [polypeptide binding]; other site
395965004334	active site residues [active]
395965004335	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
395965004336	HsdM N-terminal domain; Region: HsdM_N; pfam12161
395965004337	Methyltransferase domain; Region: Methyltransf_26; pfam13659
395965004338	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
395965004339	Uncharacterized conserved protein [Function unknown]; Region: COG4127
395965004340	Restriction endonuclease; Region: Mrr_cat; pfam04471
395965004341	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
395965004342	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
395965004343	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395965004344	ATP binding site [chemical binding]; other site
395965004345	putative Mg++ binding site [ion binding]; other site
395965004346	integrase; Provisional; Region: PRK09692
395965004347	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
395965004348	active site
395965004349	Int/Topo IB signature motif; other site
395965004350	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
395965004351	HemY protein N-terminus; Region: HemY_N; pfam07219
395965004352	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
395965004353	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
395965004354	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
395965004355	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965004356	S-adenosylmethionine binding site [chemical binding]; other site
395965004357	aspartate kinase; Reviewed; Region: PRK06635
395965004358	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
395965004359	putative nucleotide binding site [chemical binding]; other site
395965004360	putative catalytic residues [active]
395965004361	putative Mg ion binding site [ion binding]; other site
395965004362	putative aspartate binding site [chemical binding]; other site
395965004363	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
395965004364	putative allosteric regulatory site; other site
395965004365	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
395965004366	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
395965004367	GAF domain; Region: GAF; pfam01590
395965004368	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
395965004369	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
395965004370	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
395965004371	peptide chain release factor 1; Validated; Region: prfA; PRK00591
395965004372	This domain is found in peptide chain release factors; Region: PCRF; smart00937
395965004373	RF-1 domain; Region: RF-1; pfam00472
395965004374	Predicted membrane protein [Function unknown]; Region: COG2510
395965004375	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
395965004376	substrate binding site [chemical binding]; other site
395965004377	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395965004378	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395965004379	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
395965004380	Putative serine esterase (DUF676); Region: DUF676; pfam05057
395965004381	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
395965004382	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
395965004383	purine monophosphate binding site [chemical binding]; other site
395965004384	dimer interface [polypeptide binding]; other site
395965004385	putative catalytic residues [active]
395965004386	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
395965004387	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
395965004388	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
395965004389	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
395965004390	metal-binding site [ion binding]
395965004391	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
395965004392	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
395965004393	metal-binding site [ion binding]
395965004394	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395965004395	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
395965004396	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
395965004397	AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255
395965004398	putative nucleotide binding site [chemical binding]; other site
395965004399	putative substrate binding site [chemical binding]; other site
395965004400	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
395965004401	nucleotide binding site [chemical binding]; other site
395965004402	substrate binding site [chemical binding]; other site
395965004403	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
395965004404	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
395965004405	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
395965004406	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395965004407	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
395965004408	catalytic center binding site [active]
395965004409	ATP binding site [chemical binding]; other site
395965004410	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
395965004411	dihydropteroate synthase; Region: DHPS; TIGR01496
395965004412	substrate binding pocket [chemical binding]; other site
395965004413	dimer interface [polypeptide binding]; other site
395965004414	inhibitor binding site; inhibition site
395965004415	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
395965004416	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395965004417	substrate binding pocket [chemical binding]; other site
395965004418	membrane-bound complex binding site; other site
395965004419	hinge residues; other site
395965004420	c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874
395965004421	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
395965004422	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
395965004423	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
395965004424	Trp docking motif [polypeptide binding]; other site
395965004425	dimer interface [polypeptide binding]; other site
395965004426	active site
395965004427	small subunit binding site [polypeptide binding]; other site
395965004428	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395965004429	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
395965004430	dimer interface [polypeptide binding]; other site
395965004431	N-terminal domain interface [polypeptide binding]; other site
395965004432	putative substrate binding pocket (H-site) [chemical binding]; other site
395965004433	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
395965004434	Methyltransferase domain; Region: Methyltransf_26; pfam13659
395965004435	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
395965004436	B1 nucleotide binding pocket [chemical binding]; other site
395965004437	B2 nucleotide binding pocket [chemical binding]; other site
395965004438	CAS motifs; other site
395965004439	active site
395965004440	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
395965004441	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
395965004442	Substrate binding site; other site
395965004443	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
395965004444	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
395965004445	RNA/DNA hybrid binding site [nucleotide binding]; other site
395965004446	active site
395965004447	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
395965004448	DNA methylase; Region: N6_N4_Mtase; pfam01555
395965004449	SnoaL-like domain; Region: SnoaL_2; pfam12680
395965004450	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
395965004451	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
395965004452	minor groove reading motif; other site
395965004453	helix-hairpin-helix signature motif; other site
395965004454	substrate binding pocket [chemical binding]; other site
395965004455	active site
395965004456	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
395965004457	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
395965004458	DNA binding and oxoG recognition site [nucleotide binding]
395965004459	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
395965004460	putative dimer interface [polypeptide binding]; other site
395965004461	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395965004462	Protein of unknown function (DUF721); Region: DUF721; cl02324
395965004463	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
395965004464	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
395965004465	catalytic residues [active]
395965004466	Domain of unknown function DUF59; Region: DUF59; cl00941
395965004467	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
395965004468	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
395965004469	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
395965004470	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
395965004471	Walker A/P-loop; other site
395965004472	ATP binding site [chemical binding]; other site
395965004473	Q-loop/lid; other site
395965004474	ABC transporter signature motif; other site
395965004475	Walker B; other site
395965004476	D-loop; other site
395965004477	H-loop/switch region; other site
395965004478	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
395965004479	putative ABC transporter; Region: ycf24; CHL00085
395965004480	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395965004481	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
395965004482	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395965004483	catalytic residue [active]
395965004484	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
395965004485	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395965004486	Uncharacterized conserved protein [Function unknown]; Region: COG2128
395965004487	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
395965004488	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
395965004489	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
395965004490	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
395965004491	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
395965004492	active site
395965004493	HIGH motif; other site
395965004494	dimer interface [polypeptide binding]; other site
395965004495	KMSKS motif; other site
395965004496	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395965004497	RNA binding surface [nucleotide binding]; other site
395965004498	Novel bacterial esterase 713 that cleaves esters on halogenated cyclic compounds; Region: Esterase_713; cd12807
395965004499	catalytic site [active]
395965004500	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
395965004501	Protein of unknown function; Region: DUF3971; pfam13116
395965004502	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
395965004503	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
395965004504	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
395965004505	catalytic triad [active]
395965004506	Protein of unknown function (DUF1134); Region: DUF1134; pfam06577
395965004507	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
395965004508	active site
395965004509	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
395965004510	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
395965004511	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
395965004512	catalytic site [active]
395965004513	subunit interface [polypeptide binding]; other site
395965004514	Yqey-like protein; Region: YqeY; pfam09424
395965004515	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
395965004516	Beta-lactamase; Region: Beta-lactamase; pfam00144
395965004517	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
395965004518	oligomerization interface [polypeptide binding]; other site
395965004519	active site
395965004520	metal binding site [ion binding]; metal-binding site
395965004521	DNA primase; Validated; Region: dnaG; PRK05667
395965004522	CHC2 zinc finger; Region: zf-CHC2; cl17510
395965004523	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
395965004524	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
395965004525	active site
395965004526	metal binding site [ion binding]; metal-binding site
395965004527	interdomain interaction site; other site
395965004528	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
395965004529	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
395965004530	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
395965004531	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
395965004532	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395965004533	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
395965004534	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395965004535	DNA binding residues [nucleotide binding]
395965004536	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
395965004537	putative FMN binding site [chemical binding]; other site
395965004538	GTP-binding protein YchF; Reviewed; Region: PRK09601
395965004539	YchF GTPase; Region: YchF; cd01900
395965004540	G1 box; other site
395965004541	GTP/Mg2+ binding site [chemical binding]; other site
395965004542	Switch I region; other site
395965004543	G2 box; other site
395965004544	Switch II region; other site
395965004545	G3 box; other site
395965004546	G4 box; other site
395965004547	G5 box; other site
395965004548	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
395965004549	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
395965004550	putative active site [active]
395965004551	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
395965004552	putative active site [active]
395965004553	catalytic residue [active]
395965004554	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
395965004555	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
395965004556	5S rRNA interface [nucleotide binding]; other site
395965004557	CTC domain interface [polypeptide binding]; other site
395965004558	L16 interface [polypeptide binding]; other site
395965004559	Protein of unknown function (DUF419); Region: DUF419; cl15265
395965004560	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
395965004561	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
395965004562	Cl- selectivity filter; other site
395965004563	Cl- binding residues [ion binding]; other site
395965004564	pore gating glutamate residue; other site
395965004565	dimer interface [polypeptide binding]; other site
395965004566	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395965004567	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
395965004568	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
395965004569	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395965004570	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395965004571	NAD(P) binding site [chemical binding]; other site
395965004572	active site
395965004573	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395965004574	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965004575	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395965004576	dimerization interface [polypeptide binding]; other site
395965004577	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
395965004578	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965004579	Walker A motif; other site
395965004580	ATP binding site [chemical binding]; other site
395965004581	Walker B motif; other site
395965004582	arginine finger; other site
395965004583	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
395965004584	Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Region: AceE; COG2609
395965004585	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
395965004586	TPP-binding site [chemical binding]; other site
395965004587	PYR/PP interface [polypeptide binding]; other site
395965004588	dimer interface [polypeptide binding]; other site
395965004589	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
395965004590	TPP binding site [chemical binding]; other site
395965004591	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395965004592	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
395965004593	putative DNA binding site [nucleotide binding]; other site
395965004594	putative Zn2+ binding site [ion binding]; other site
395965004595	AsnC family; Region: AsnC_trans_reg; pfam01037
395965004596	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
395965004597	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
395965004598	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
395965004599	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
395965004600	dimer interface [polypeptide binding]; other site
395965004601	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395965004602	active site
395965004603	metal binding site [ion binding]; metal-binding site
395965004604	glutathione binding site [chemical binding]; other site
395965004605	Cytochrome c; Region: Cytochrom_C; cl11414
395965004606	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
395965004607	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
395965004608	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965004609	Walker A motif; other site
395965004610	ATP binding site [chemical binding]; other site
395965004611	Walker B motif; other site
395965004612	arginine finger; other site
395965004613	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395965004614	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
395965004615	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
395965004616	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
395965004617	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
395965004618	dimerization interface [polypeptide binding]; other site
395965004619	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
395965004620	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395965004621	catalytic loop [active]
395965004622	iron binding site [ion binding]; other site
395965004623	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212
395965004624	FAD binding pocket [chemical binding]; other site
395965004625	FAD binding motif [chemical binding]; other site
395965004626	phosphate binding motif [ion binding]; other site
395965004627	beta-alpha-beta structure motif; other site
395965004628	NAD binding pocket [chemical binding]; other site
395965004629	Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
395965004630	dimerization interface [polypeptide binding]; other site
395965004631	putative path to active site cavity [active]
395965004632	diiron center [ion binding]; other site
395965004633	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
395965004634	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
395965004635	putative acyl-acceptor binding pocket; other site
395965004636	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
395965004637	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395965004638	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
395965004639	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
395965004640	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
395965004641	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
395965004642	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
395965004643	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395965004644	Walker A motif; other site
395965004645	ATP binding site [chemical binding]; other site
395965004646	Walker B motif; other site
395965004647	hypothetical protein; Provisional; Region: PRK02237
395965004648	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
395965004649	Proline dehydrogenase; Region: Pro_dh; pfam01619
395965004650	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
395965004651	Glutamate binding site [chemical binding]; other site
395965004652	NAD binding site [chemical binding]; other site
395965004653	catalytic residues [active]
395965004654	ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885
395965004655	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395965004656	inhibitor-cofactor binding pocket; inhibition site
395965004657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965004658	catalytic residue [active]
395965004659	hypothetical protein; Provisional; Region: PRK05170
395965004660	Transglycosylase; Region: Transgly; pfam00912
395965004661	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
395965004662	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
395965004663	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
395965004664	Predicted integral membrane protein [Function unknown]; Region: COG5436
395965004665	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
395965004666	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
395965004667	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395965004668	PAS domain; Region: PAS; smart00091
395965004669	putative active site [active]
395965004670	heme pocket [chemical binding]; other site
395965004671	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395965004672	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965004673	dimer interface [polypeptide binding]; other site
395965004674	phosphorylation site [posttranslational modification]
395965004675	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965004676	ATP binding site [chemical binding]; other site
395965004677	Mg2+ binding site [ion binding]; other site
395965004678	G-X-G motif; other site
395965004679	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
395965004680	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
395965004681	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
395965004682	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395965004683	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
395965004684	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
395965004685	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
395965004686	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
395965004687	30S subunit binding site; other site
395965004688	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
395965004689	RNA binding site [nucleotide binding]; other site
395965004690	LexA repressor; Validated; Region: PRK00215
395965004691	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
395965004692	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
395965004693	Catalytic site [active]
395965004694	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
395965004695	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
395965004696	Competence protein; Region: Competence; pfam03772
395965004697	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
395965004698	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
395965004699	active site
395965004700	HIGH motif; other site
395965004701	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
395965004702	active site
395965004703	KMSKS motif; other site
395965004704	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
395965004705	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
395965004706	dimer interface [polypeptide binding]; other site
395965004707	active site
395965004708	citrylCoA binding site [chemical binding]; other site
395965004709	NADH binding [chemical binding]; other site
395965004710	cationic pore residues; other site
395965004711	oxalacetate/citrate binding site [chemical binding]; other site
395965004712	coenzyme A binding site [chemical binding]; other site
395965004713	catalytic triad [active]
395965004714	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
395965004715	putative catalytic site [active]
395965004716	putative phosphate binding site [ion binding]; other site
395965004717	active site
395965004718	metal binding site A [ion binding]; metal-binding site
395965004719	DNA binding site [nucleotide binding]
395965004720	putative AP binding site [nucleotide binding]; other site
395965004721	putative metal binding site B [ion binding]; other site
395965004722	Protein of unknown function DUF72; Region: DUF72; pfam01904
395965004723	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395965004724	Sel1 repeat; Region: Sel1; cl02723
395965004725	Sel1-like repeats; Region: SEL1; smart00671
395965004726	manganese transport regulator MntR; Provisional; Region: PRK11050
395965004727	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
395965004728	manganese transport protein MntH; Reviewed; Region: PRK00701
395965004729	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
395965004730	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
395965004731	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
395965004732	HIGH motif; other site
395965004733	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
395965004734	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
395965004735	active site
395965004736	KMSKS motif; other site
395965004737	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
395965004738	tRNA binding surface [nucleotide binding]; other site
395965004739	anticodon binding site; other site
395965004740	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
395965004741	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
395965004742	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
395965004743	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
395965004744	elongation factor Ts; Provisional; Region: tsf; PRK09377
395965004745	UBA/TS-N domain; Region: UBA; pfam00627
395965004746	Elongation factor TS; Region: EF_TS; pfam00889
395965004747	Elongation factor TS; Region: EF_TS; pfam00889
395965004748	30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311
395965004749	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
395965004750	rRNA interaction site [nucleotide binding]; other site
395965004751	S8 interaction site; other site
395965004752	putative laminin-1 binding site; other site
395965004753	Uncharacterized conserved protein [Function unknown]; Region: COG3743
395965004754	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
395965004755	FAD binding domain; Region: FAD_binding_4; pfam01565
395965004756	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
395965004757	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
395965004758	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
395965004759	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
395965004760	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
395965004761	putative active site [active]
395965004762	putative PHP Thumb interface [polypeptide binding]; other site
395965004763	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
395965004764	generic binding surface II; other site
395965004765	generic binding surface I; other site
395965004766	Cupin-like domain; Region: Cupin_8; pfam13621
395965004767	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
395965004768	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
395965004769	Walker A/P-loop; other site
395965004770	ATP binding site [chemical binding]; other site
395965004771	Q-loop/lid; other site
395965004772	ABC transporter signature motif; other site
395965004773	Walker B; other site
395965004774	D-loop; other site
395965004775	H-loop/switch region; other site
395965004776	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
395965004777	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965004778	dimer interface [polypeptide binding]; other site
395965004779	conserved gate region; other site
395965004780	putative PBP binding loops; other site
395965004781	ABC-ATPase subunit interface; other site
395965004782	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
395965004783	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
395965004784	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965004785	putative PBP binding loops; other site
395965004786	dimer interface [polypeptide binding]; other site
395965004787	ABC-ATPase subunit interface; other site
395965004788	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
395965004789	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395965004790	substrate binding pocket [chemical binding]; other site
395965004791	membrane-bound complex binding site; other site
395965004792	hinge residues; other site
395965004793	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395965004794	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
395965004795	NAD(P) binding site [chemical binding]; other site
395965004796	catalytic residues [active]
395965004797	cystathionine beta-lyase; Provisional; Region: PRK05967
395965004798	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395965004799	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395965004800	catalytic residue [active]
395965004801	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
395965004802	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
395965004803	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
395965004804	Potassium binding sites [ion binding]; other site
395965004805	Cesium cation binding sites [ion binding]; other site
395965004806	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
395965004807	glycerate dehydrogenase; Provisional; Region: PRK06487
395965004808	putative ligand binding site [chemical binding]; other site
395965004809	putative NAD binding site [chemical binding]; other site
395965004810	catalytic site [active]
395965004811	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
395965004812	homodimer interface [polypeptide binding]; other site
395965004813	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965004814	catalytic residue [active]
395965004815	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
395965004816	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
395965004817	MOFRL family; Region: MOFRL; pfam05161
395965004818	malate--CoA ligase subunit beta; Provisional; Region: PRK14046
395965004819	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
395965004820	CoA-ligase; Region: Ligase_CoA; pfam00549
395965004821	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
395965004822	CoA binding domain; Region: CoA_binding; smart00881
395965004823	CoA-ligase; Region: Ligase_CoA; pfam00549
395965004824	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
395965004825	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
395965004826	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
395965004827	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
395965004828	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395965004829	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
395965004830	Iron-sulfur protein interface; other site
395965004831	proximal quinone binding site [chemical binding]; other site
395965004832	C-subunit interface; other site
395965004833	distal quinone binding site; other site
395965004834	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
395965004835	Iron-sulfur protein interface; other site
395965004836	proximal heme binding site [chemical binding]; other site
395965004837	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
395965004838	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
395965004839	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
395965004840	L-aspartate oxidase; Provisional; Region: PRK06175
395965004841	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
395965004842	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
395965004843	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
395965004844	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
395965004845	Moco binding site; other site
395965004846	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
395965004847	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
395965004848	active site
395965004849	DNA binding site [nucleotide binding]
395965004850	Int/Topo IB signature motif; other site
395965004851	catalytic residues [active]
395965004852	Protein of unknown function (DUF763); Region: DUF763; pfam05559
395965004853	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
395965004854	Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666
395965004855	DNA binding site [nucleotide binding]
395965004856	heterodimer interface [polypeptide binding]; other site
395965004857	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
395965004858	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
395965004859	putative DNA binding site [nucleotide binding]; other site
395965004860	putative homodimer interface [polypeptide binding]; other site
395965004861	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
395965004862	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
395965004863	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
395965004864	active site
395965004865	DNA binding site [nucleotide binding]
395965004866	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
395965004867	DNA binding site [nucleotide binding]
395965004868	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
395965004869	nucleotide binding site [chemical binding]; other site
395965004870	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395965004871	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
395965004872	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
395965004873	[2Fe-2S] cluster binding site [ion binding]; other site
395965004874	dimer interface [polypeptide binding]; other site
395965004875	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
395965004876	glutathionine S-transferase; Provisional; Region: PRK10542
395965004877	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
395965004878	C-terminal domain interface [polypeptide binding]; other site
395965004879	GSH binding site (G-site) [chemical binding]; other site
395965004880	dimer interface [polypeptide binding]; other site
395965004881	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
395965004882	dimer interface [polypeptide binding]; other site
395965004883	substrate binding pocket (H-site) [chemical binding]; other site
395965004884	N-terminal domain interface [polypeptide binding]; other site
395965004885	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
395965004886	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
395965004887	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395965004888	active site
395965004889	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
395965004890	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
395965004891	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
395965004892	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
395965004893	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
395965004894	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
395965004895	substrate binding site [chemical binding]; other site
395965004896	oxyanion hole (OAH) forming residues; other site
395965004897	trimer interface [polypeptide binding]; other site
395965004898	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
395965004899	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
395965004900	dimer interface [polypeptide binding]; other site
395965004901	active site
395965004902	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
395965004903	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
395965004904	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
395965004905	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
395965004906	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
395965004907	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395965004908	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
395965004909	DNA binding residues [nucleotide binding]
395965004910	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
395965004911	putative dimer interface [polypeptide binding]; other site
395965004912	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395965004913	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395965004914	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395965004915	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395965004916	Predicted periplasmic protein [Function unknown]; Region: COG3904
395965004917	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
395965004918	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395965004919	motif II; other site
395965004920	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
395965004921	G8 domain; Region: G8; pfam10162
395965004922	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
395965004923	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395965004924	catalytic residue [active]
395965004925	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
395965004926	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
395965004927	ligand binding site [chemical binding]; other site
395965004928	NAD binding site [chemical binding]; other site
395965004929	dimerization interface [polypeptide binding]; other site
395965004930	catalytic site [active]
395965004931	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
395965004932	putative L-serine binding site [chemical binding]; other site
395965004933	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
395965004934	active site
395965004935	catalytic residues [active]
395965004936	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395965004937	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965004938	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
395965004939	putative substrate binding pocket [chemical binding]; other site
395965004940	putative dimerization interface [polypeptide binding]; other site
395965004941	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
395965004942	ArsC family; Region: ArsC; pfam03960
395965004943	putative catalytic residues [active]
395965004944	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
395965004945	apolar tunnel; other site
395965004946	heme binding site [chemical binding]; other site
395965004947	dimerization interface [polypeptide binding]; other site
395965004948	Putative ammonia monooxygenase; Region: AmoA; pfam05145
395965004949	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
395965004950	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
395965004951	Isochorismatase family; Region: Isochorismatase; pfam00857
395965004952	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
395965004953	catalytic triad [active]
395965004954	conserved cis-peptide bond; other site
395965004955	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965004956	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965004957	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
395965004958	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965004959	Walker A motif; other site
395965004960	ATP binding site [chemical binding]; other site
395965004961	Walker B motif; other site
395965004962	arginine finger; other site
395965004963	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
395965004964	FMN binding site [chemical binding]; other site
395965004965	dimer interface [polypeptide binding]; other site
395965004966	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
395965004967	putative FMN binding site [chemical binding]; other site
395965004968	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
395965004969	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395965004970	Domain of unknown function (DUF336); Region: DUF336; pfam03928
395965004971	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
395965004972	homotrimer interface [polypeptide binding]; other site
395965004973	Walker A motif; other site
395965004974	GTP binding site [chemical binding]; other site
395965004975	Walker B motif; other site
395965004976	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
395965004977	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
395965004978	Active Sites [active]
395965004979	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
395965004980	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
395965004981	CysD dimerization site [polypeptide binding]; other site
395965004982	G1 box; other site
395965004983	putative GEF interaction site [polypeptide binding]; other site
395965004984	GTP/Mg2+ binding site [chemical binding]; other site
395965004985	Switch I region; other site
395965004986	G2 box; other site
395965004987	G3 box; other site
395965004988	Switch II region; other site
395965004989	G4 box; other site
395965004990	G5 box; other site
395965004991	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
395965004992	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
395965004993	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
395965004994	ligand-binding site [chemical binding]; other site
395965004995	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
395965004996	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
395965004997	sulfite reductase; Provisional; Region: PRK06214
395965004998	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
395965004999	FAD binding pocket [chemical binding]; other site
395965005000	FAD binding motif [chemical binding]; other site
395965005001	catalytic residues [active]
395965005002	NAD binding pocket [chemical binding]; other site
395965005003	phosphate binding motif [ion binding]; other site
395965005004	beta-alpha-beta structure motif; other site
395965005005	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567
395965005006	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395965005007	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395965005008	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
395965005009	TPR repeat; Region: TPR_11; pfam13414
395965005010	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965005011	TPR motif; other site
395965005012	TPR repeat; Region: TPR_11; pfam13414
395965005013	binding surface
395965005014	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395965005015	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395965005016	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
395965005017	catalytic site [active]
395965005018	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
395965005019	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
395965005020	MarC family integral membrane protein; Region: MarC; pfam01914
395965005021	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
395965005022	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
395965005023	PhoU domain; Region: PhoU; pfam01895
395965005024	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
395965005025	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
395965005026	putative active site [active]
395965005027	Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685
395965005028	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
395965005029	active site
395965005030	catalytic motif [active]
395965005031	Zn binding site [ion binding]; other site
395965005032	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
395965005033	DNA-binding site [nucleotide binding]; DNA binding site
395965005034	RNA-binding motif; other site
395965005035	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
395965005036	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
395965005037	putative FMN binding site [chemical binding]; other site
395965005038	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
395965005039	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
395965005040	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
395965005041	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
395965005042	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
395965005043	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
395965005044	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
395965005045	catalytic triad [active]
395965005046	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
395965005047	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
395965005048	Imelysin; Region: Peptidase_M75; pfam09375
395965005049	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
395965005050	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
395965005051	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
395965005052	Imelysin; Region: Peptidase_M75; pfam09375
395965005053	Iron permease FTR1 family; Region: FTR1; cl00475
395965005054	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395965005055	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
395965005056	Biofilm formation and stress response factor; Region: BsmA; pfam10014
395965005057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965005058	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
395965005059	putative substrate translocation pore; other site
395965005060	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
395965005061	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965005062	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965005063	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
395965005064	Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment  includes type II...; Region: PIPKc; cl02572
395965005065	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
395965005066	elongation factor G; Reviewed; Region: PRK12740
395965005067	G1 box; other site
395965005068	GTP/Mg2+ binding site [chemical binding]; other site
395965005069	G2 box; other site
395965005070	Switch I region; other site
395965005071	G3 box; other site
395965005072	Switch II region; other site
395965005073	G4 box; other site
395965005074	G5 box; other site
395965005075	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
395965005076	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
395965005077	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
395965005078	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
395965005079	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
395965005080	threonine dehydratase; Reviewed; Region: PRK09224
395965005081	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
395965005082	tetramer interface [polypeptide binding]; other site
395965005083	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965005084	catalytic residue [active]
395965005085	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
395965005086	putative Ile/Val binding site [chemical binding]; other site
395965005087	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
395965005088	putative Ile/Val binding site [chemical binding]; other site
395965005089	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
395965005090	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
395965005091	NAD binding site [chemical binding]; other site
395965005092	substrate binding site [chemical binding]; other site
395965005093	catalytic Zn binding site [ion binding]; other site
395965005094	tetramer interface [polypeptide binding]; other site
395965005095	structural Zn binding site [ion binding]; other site
395965005096	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
395965005097	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
395965005098	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
395965005099	transcriptional regulator FixK; Provisional; Region: fixK; PRK09391
395965005100	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395965005101	ligand binding site [chemical binding]; other site
395965005102	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
395965005103	putative switch regulator; other site
395965005104	non-specific DNA interactions [nucleotide binding]; other site
395965005105	DNA binding site [nucleotide binding]
395965005106	sequence specific DNA binding site [nucleotide binding]; other site
395965005107	putative cAMP binding site [chemical binding]; other site
395965005108	Response regulator receiver domain; Region: Response_reg; pfam00072
395965005109	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965005110	active site
395965005111	phosphorylation site [posttranslational modification]
395965005112	intermolecular recognition site; other site
395965005113	dimerization interface [polypeptide binding]; other site
395965005114	response regulator FixJ; Provisional; Region: fixJ; PRK09390
395965005115	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965005116	active site
395965005117	phosphorylation site [posttranslational modification]
395965005118	intermolecular recognition site; other site
395965005119	dimerization interface [polypeptide binding]; other site
395965005120	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395965005121	DNA binding residues [nucleotide binding]
395965005122	dimerization interface [polypeptide binding]; other site
395965005123	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395965005124	putative active site [active]
395965005125	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
395965005126	heme pocket [chemical binding]; other site
395965005127	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395965005128	putative active site [active]
395965005129	heme pocket [chemical binding]; other site
395965005130	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965005131	dimer interface [polypeptide binding]; other site
395965005132	phosphorylation site [posttranslational modification]
395965005133	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965005134	ATP binding site [chemical binding]; other site
395965005135	Mg2+ binding site [ion binding]; other site
395965005136	G-X-G motif; other site
395965005137	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
395965005138	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
395965005139	catalytic Zn binding site [ion binding]; other site
395965005140	structural Zn binding site [ion binding]; other site
395965005141	NAD(P) binding site [chemical binding]; other site
395965005142	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
395965005143	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
395965005144	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
395965005145	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
395965005146	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
395965005147	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
395965005148	glutamate--cysteine ligase; Region: PLN02611
395965005149	SWI complex, BAF60b domains; Region: SWIB; smart00151
395965005150	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
395965005151	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
395965005152	23S rRNA binding site [nucleotide binding]; other site
395965005153	L21 binding site [polypeptide binding]; other site
395965005154	L13 binding site [polypeptide binding]; other site
395965005155	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
395965005156	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
395965005157	putative tRNA-binding site [nucleotide binding]; other site
395965005158	B3/4 domain; Region: B3_4; pfam03483
395965005159	tRNA synthetase B5 domain; Region: B5; smart00874
395965005160	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
395965005161	dimer interface [polypeptide binding]; other site
395965005162	motif 1; other site
395965005163	motif 3; other site
395965005164	motif 2; other site
395965005165	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
395965005166	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
395965005167	putative metal binding site [ion binding]; other site
395965005168	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
395965005169	classical (c) SDRs; Region: SDR_c; cd05233
395965005170	NAD(P) binding site [chemical binding]; other site
395965005171	active site
395965005172	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
395965005173	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
395965005174	catalytic triad [active]
395965005175	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
395965005176	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
395965005177	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
395965005178	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
395965005179	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395965005180	DNA-binding site [nucleotide binding]; DNA binding site
395965005181	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395965005182	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965005183	homodimer interface [polypeptide binding]; other site
395965005184	catalytic residue [active]
395965005185	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
395965005186	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
395965005187	active site
395965005188	DNA binding site [nucleotide binding]
395965005189	Int/Topo IB signature motif; other site
395965005190	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
395965005191	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
395965005192	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395965005193	FeS/SAM binding site; other site
395965005194	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
395965005195	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
395965005196	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
395965005197	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
395965005198	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
395965005199	catalytic site [active]
395965005200	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
395965005201	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395965005202	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395965005203	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
395965005204	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
395965005205	substrate binding site [chemical binding]; other site
395965005206	Coenzyme A transferase; Region: CoA_trans; cl17247
395965005207	Coenzyme A transferase; Region: CoA_trans; cl17247
395965005208	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
395965005209	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
395965005210	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
395965005211	active site
395965005212	dimer interface [polypeptide binding]; other site
395965005213	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
395965005214	dimer interface [polypeptide binding]; other site
395965005215	active site
395965005216	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
395965005217	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
395965005218	Nitrogen regulatory protein P-II; Region: P-II; smart00938
395965005219	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
395965005220	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
395965005221	active site
395965005222	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
395965005223	catalytic triad [active]
395965005224	dimer interface [polypeptide binding]; other site
395965005225	Uncharacterized conserved protein [Function unknown]; Region: COG2835
395965005226	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
395965005227	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
395965005228	catalytic residues [active]
395965005229	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
395965005230	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395965005231	putative active site [active]
395965005232	putative metal binding site [ion binding]; other site
395965005233	Putative integral membrane protein DUF46; Region: DUF46; cl17511
395965005234	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
395965005235	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
395965005236	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965005237	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
395965005238	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
395965005239	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
395965005240	23S rRNA interface [nucleotide binding]; other site
395965005241	L3 interface [polypeptide binding]; other site
395965005242	Cupin domain; Region: Cupin_2; cl17218
395965005243	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
395965005244	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
395965005245	oligomeric interface; other site
395965005246	putative active site [active]
395965005247	homodimer interface [polypeptide binding]; other site
395965005248	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
395965005249	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
395965005250	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
395965005251	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
395965005252	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
395965005253	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
395965005254	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
395965005255	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
395965005256	homodimer interface [polypeptide binding]; other site
395965005257	NADP binding site [chemical binding]; other site
395965005258	substrate binding site [chemical binding]; other site
395965005259	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
395965005260	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395965005261	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395965005262	catalytic residue [active]
395965005263	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
395965005264	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
395965005265	active site
395965005266	catalytic residues [active]
395965005267	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
395965005268	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395965005269	dimerization interface [polypeptide binding]; other site
395965005270	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395965005271	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395965005272	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395965005273	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965005274	dimer interface [polypeptide binding]; other site
395965005275	phosphorylation site [posttranslational modification]
395965005276	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965005277	ATP binding site [chemical binding]; other site
395965005278	Mg2+ binding site [ion binding]; other site
395965005279	G-X-G motif; other site
395965005280	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
395965005281	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
395965005282	Response regulator receiver domain; Region: Response_reg; pfam00072
395965005283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965005284	active site
395965005285	phosphorylation site [posttranslational modification]
395965005286	intermolecular recognition site; other site
395965005287	dimerization interface [polypeptide binding]; other site
395965005288	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
395965005289	cyclase homology domain; Region: CHD; cd07302
395965005290	nucleotidyl binding site; other site
395965005291	metal binding site [ion binding]; metal-binding site
395965005292	dimer interface [polypeptide binding]; other site
395965005293	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
395965005294	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395965005295	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
395965005296	lipoyl-biotinyl attachment site [posttranslational modification]; other site
395965005297	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965005298	Caspase domain; Region: Peptidase_C14; pfam00656
395965005299	Uncharacterized conserved protein [Function unknown]; Region: COG1262
395965005300	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
395965005301	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
395965005302	B12 binding site [chemical binding]; other site
395965005303	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
395965005304	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395965005305	FeS/SAM binding site; other site
395965005306	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
395965005307	Autotransporter beta-domain; Region: Autotransporter; pfam03797
395965005308	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
395965005309	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
395965005310	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395965005311	Methyltransferase domain; Region: Methyltransf_11; pfam08241
395965005312	Predicted esterase [General function prediction only]; Region: COG0400
395965005313	putative hydrolase; Provisional; Region: PRK11460
395965005314	methionine sulfoxide reductase B; Provisional; Region: PRK00222
395965005315	SelR domain; Region: SelR; pfam01641
395965005316	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
395965005317	Predicted membrane protein [Function unknown]; Region: COG4325
395965005318	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
395965005319	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965005320	Mg2+ binding site [ion binding]; other site
395965005321	G-X-G motif; other site
395965005322	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
395965005323	anchoring element; other site
395965005324	dimer interface [polypeptide binding]; other site
395965005325	ATP binding site [chemical binding]; other site
395965005326	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
395965005327	active site
395965005328	putative metal-binding site [ion binding]; other site
395965005329	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
395965005330	Predicted membrane protein (DUF2335); Region: DUF2335; cl02210
395965005331	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
395965005332	Clp amino terminal domain; Region: Clp_N; pfam02861
395965005333	Clp amino terminal domain; Region: Clp_N; pfam02861
395965005334	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965005335	Walker A motif; other site
395965005336	ATP binding site [chemical binding]; other site
395965005337	Walker B motif; other site
395965005338	arginine finger; other site
395965005339	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965005340	Walker A motif; other site
395965005341	ATP binding site [chemical binding]; other site
395965005342	Walker B motif; other site
395965005343	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
395965005344	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
395965005345	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
395965005346	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965005347	heat shock protein 90; Provisional; Region: PRK05218
395965005348	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965005349	ATP binding site [chemical binding]; other site
395965005350	Mg2+ binding site [ion binding]; other site
395965005351	G-X-G motif; other site
395965005352	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
395965005353	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
395965005354	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
395965005355	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
395965005356	nif11 domain/cupin domain protein; Region: nif11_cupin; TIGR03890
395965005357	Predicted transporter component [General function prediction only]; Region: COG2391
395965005358	Sulphur transport; Region: Sulf_transp; pfam04143
395965005359	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
395965005360	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
395965005361	Isochorismatase family; Region: Isochorismatase; pfam00857
395965005362	catalytic triad [active]
395965005363	conserved cis-peptide bond; other site
395965005364	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
395965005365	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
395965005366	conserved cys residue [active]
395965005367	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395965005368	Domain of unknown function DUF302; Region: DUF302; pfam03625
395965005369	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
395965005370	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395965005371	Walker A/P-loop; other site
395965005372	ATP binding site [chemical binding]; other site
395965005373	Q-loop/lid; other site
395965005374	ABC transporter signature motif; other site
395965005375	Walker B; other site
395965005376	D-loop; other site
395965005377	H-loop/switch region; other site
395965005378	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
395965005379	active site
395965005380	catalytic triad [active]
395965005381	oxyanion hole [active]
395965005382	switch loop; other site
395965005383	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
395965005384	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
395965005385	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
395965005386	Phasin protein; Region: Phasin_2; pfam09361
395965005387	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395965005388	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965005389	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
395965005390	putative effector binding pocket; other site
395965005391	putative dimerization interface [polypeptide binding]; other site
395965005392	short chain dehydrogenase; Provisional; Region: PRK06180
395965005393	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395965005394	NADP binding site [chemical binding]; other site
395965005395	active site
395965005396	steroid binding site; other site
395965005397	Cytochrome P450; Region: p450; cl12078
395965005398	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
395965005399	Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269
395965005400	Hemin uptake protein hemP; Region: hemP; pfam10636
395965005401	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
395965005402	intersubunit interface [polypeptide binding]; other site
395965005403	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
395965005404	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395965005405	dimer interface [polypeptide binding]; other site
395965005406	putative PBP binding regions; other site
395965005407	ABC-ATPase subunit  interface; other site
395965005408	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
395965005409	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
395965005410	Walker A/P-loop; other site
395965005411	ATP binding site [chemical binding]; other site
395965005412	Q-loop/lid; other site
395965005413	ABC transporter signature motif; other site
395965005414	Walker B; other site
395965005415	D-loop; other site
395965005416	H-loop/switch region; other site
395965005417	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
395965005418	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
395965005419	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395965005420	N-terminal plug; other site
395965005421	ligand-binding site [chemical binding]; other site
395965005422	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
395965005423	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
395965005424	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
395965005425	Ligand Binding Site [chemical binding]; other site
395965005426	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395965005427	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965005428	S-adenosylmethionine binding site [chemical binding]; other site
395965005429	Protein of unknown function (DUF465); Region: DUF465; cl01070
395965005430	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
395965005431	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
395965005432	catalytic residues [active]
395965005433	catalytic nucleophile [active]
395965005434	Recombinase; Region: Recombinase; pfam07508
395965005435	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
395965005436	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
395965005437	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395965005438	ATP binding site [chemical binding]; other site
395965005439	putative Mg++ binding site [ion binding]; other site
395965005440	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395965005441	nucleotide binding region [chemical binding]; other site
395965005442	ATP-binding site [chemical binding]; other site
395965005443	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
395965005444	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
395965005445	DNA methylase; Region: N6_N4_Mtase; pfam01555
395965005446	DNA methylase; Region: N6_N4_Mtase; pfam01555
395965005447	Restriction endonuclease [Defense mechanisms]; Region: COG3587
395965005448	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
395965005449	ATP binding site [chemical binding]; other site
395965005450	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
395965005451	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
395965005452	ThiF family; Region: ThiF; pfam00899
395965005453	ATP binding site [chemical binding]; other site
395965005454	Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462
395965005455	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
395965005456	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395965005457	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395965005458	non-specific DNA binding site [nucleotide binding]; other site
395965005459	salt bridge; other site
395965005460	sequence-specific DNA binding site [nucleotide binding]; other site
395965005461	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
395965005462	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
395965005463	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
395965005464	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
395965005465	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
395965005466	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
395965005467	HSP70 interaction site [polypeptide binding]; other site
395965005468	AAA-like domain; Region: AAA_10; pfam12846
395965005469	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395965005470	Walker A motif; other site
395965005471	ATP binding site [chemical binding]; other site
395965005472	Walker B motif; other site
395965005473	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
395965005474	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
395965005475	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
395965005476	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
395965005477	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
395965005478	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
395965005479	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
395965005480	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395965005481	putative NAD(P) binding site [chemical binding]; other site
395965005482	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395965005483	salt bridge; other site
395965005484	non-specific DNA binding site [nucleotide binding]; other site
395965005485	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395965005486	sequence-specific DNA binding site [nucleotide binding]; other site
395965005487	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965005488	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965005489	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
395965005490	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395965005491	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965005492	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965005493	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
395965005494	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
395965005495	putative NAD(P) binding site [chemical binding]; other site
395965005496	dimer interface [polypeptide binding]; other site
395965005497	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
395965005498	catalytic site [active]
395965005499	Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566
395965005500	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
395965005501	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395965005502	DNA-binding site [nucleotide binding]; DNA binding site
395965005503	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395965005504	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965005505	homodimer interface [polypeptide binding]; other site
395965005506	catalytic residue [active]
395965005507	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
395965005508	Predicted amidohydrolase [General function prediction only]; Region: COG0388
395965005509	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
395965005510	putative active site [active]
395965005511	catalytic triad [active]
395965005512	putative dimer interface [polypeptide binding]; other site
395965005513	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
395965005514	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395965005515	FeS/SAM binding site; other site
395965005516	putative N-acetyltransferase, MSMEG_0567 N-terminal domain family; Region: MSMEG_0567_GNAT; TIGR04045
395965005517	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
395965005518	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
395965005519	dimerization interface [polypeptide binding]; other site
395965005520	putative ATP binding site [chemical binding]; other site
395965005521	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
395965005522	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395965005523	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
395965005524	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
395965005525	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395965005526	probable biosynthetic protein, Pnap_2097 family; Region: biosn_Pnap_2097; TIGR04099
395965005527	Na binding site [ion binding]; other site
395965005528	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
395965005529	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395965005530	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965005531	dimer interface [polypeptide binding]; other site
395965005532	phosphorylation site [posttranslational modification]
395965005533	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965005534	ATP binding site [chemical binding]; other site
395965005535	Mg2+ binding site [ion binding]; other site
395965005536	G-X-G motif; other site
395965005537	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395965005538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965005539	active site
395965005540	phosphorylation site [posttranslational modification]
395965005541	intermolecular recognition site; other site
395965005542	dimerization interface [polypeptide binding]; other site
395965005543	Response regulator receiver domain; Region: Response_reg; pfam00072
395965005544	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965005545	active site
395965005546	phosphorylation site [posttranslational modification]
395965005547	intermolecular recognition site; other site
395965005548	dimerization interface [polypeptide binding]; other site
395965005549	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395965005550	DNA binding residues [nucleotide binding]
395965005551	dimerization interface [polypeptide binding]; other site
395965005552	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
395965005553	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
395965005554	Walker A/P-loop; other site
395965005555	ATP binding site [chemical binding]; other site
395965005556	Q-loop/lid; other site
395965005557	ABC transporter signature motif; other site
395965005558	Walker B; other site
395965005559	D-loop; other site
395965005560	H-loop/switch region; other site
395965005561	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
395965005562	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
395965005563	Walker A/P-loop; other site
395965005564	ATP binding site [chemical binding]; other site
395965005565	Q-loop/lid; other site
395965005566	ABC transporter signature motif; other site
395965005567	Walker B; other site
395965005568	D-loop; other site
395965005569	H-loop/switch region; other site
395965005570	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
395965005571	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
395965005572	TM-ABC transporter signature motif; other site
395965005573	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
395965005574	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395965005575	TM-ABC transporter signature motif; other site
395965005576	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
395965005577	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
395965005578	putative ligand binding site [chemical binding]; other site
395965005579	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395965005580	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
395965005581	UreF; Region: UreF; pfam01730
395965005582	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
395965005583	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
395965005584	dimer interface [polypeptide binding]; other site
395965005585	catalytic residues [active]
395965005586	urease subunit alpha; Reviewed; Region: ureC; PRK13207
395965005587	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
395965005588	subunit interactions [polypeptide binding]; other site
395965005589	active site
395965005590	flap region; other site
395965005591	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
395965005592	gamma-beta subunit interface [polypeptide binding]; other site
395965005593	alpha-beta subunit interface [polypeptide binding]; other site
395965005594	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
395965005595	alpha-gamma subunit interface [polypeptide binding]; other site
395965005596	beta-gamma subunit interface [polypeptide binding]; other site
395965005597	UreD urease accessory protein; Region: UreD; pfam01774
395965005598	Transposase; Region: HTH_Tnp_1; cl17663
395965005599	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395965005600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965005601	active site
395965005602	phosphorylation site [posttranslational modification]
395965005603	intermolecular recognition site; other site
395965005604	dimerization interface [polypeptide binding]; other site
395965005605	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395965005606	DNA binding residues [nucleotide binding]
395965005607	dimerization interface [polypeptide binding]; other site
395965005608	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
395965005609	GAF domain; Region: GAF; pfam01590
395965005610	Phytochrome region; Region: PHY; pfam00360
395965005611	Histidine kinase; Region: HisKA_3; pfam07730
395965005612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965005613	ATP binding site [chemical binding]; other site
395965005614	Mg2+ binding site [ion binding]; other site
395965005615	G-X-G motif; other site
395965005616	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
395965005617	heme binding pocket [chemical binding]; other site
395965005618	heme ligand [chemical binding]; other site
395965005619	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
395965005620	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965005621	S-adenosylmethionine binding site [chemical binding]; other site
395965005622	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
395965005623	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
395965005624	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395965005625	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
395965005626	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
395965005627	substrate binding pocket [chemical binding]; other site
395965005628	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
395965005629	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
395965005630	phytoene desaturase; Region: crtI_fam; TIGR02734
395965005631	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
395965005632	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
395965005633	substrate-cofactor binding pocket; other site
395965005634	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965005635	catalytic residue [active]
395965005636	Protein of unknown function (DUF3623); Region: DUF3623; pfam12291
395965005637	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
395965005638	diiron binding motif [ion binding]; other site
395965005639	putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054
395965005640	Bacterial PH domain; Region: DUF304; pfam03703
395965005641	photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150
395965005642	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581
395965005643	subunit C interaction residues; other site
395965005644	subunit M interaction residues [polypeptide binding]; other site
395965005645	subunit L interaction residues [polypeptide binding]; other site
395965005646	putative proton transfer pathway, P1; other site
395965005647	putative proton transfer pathway, P2; other site
395965005648	PUCC protein; Region: PUCC; pfam03209
395965005649	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
395965005650	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965005651	S-adenosylmethionine binding site [chemical binding]; other site
395965005652	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
395965005653	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
395965005654	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
395965005655	P-loop; other site
395965005656	magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405
395965005657	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
395965005658	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
395965005659	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
395965005660	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
395965005661	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
395965005662	light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842
395965005663	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
395965005664	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
395965005665	B12 binding domain; Region: B12-binding_2; pfam02607
395965005666	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
395965005667	B12 binding domain; Region: B12-binding; pfam02310
395965005668	B12 binding site [chemical binding]; other site
395965005669	transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040
395965005670	PAS domain; Region: PAS; smart00091
395965005671	putative active site [active]
395965005672	heme pocket [chemical binding]; other site
395965005673	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395965005674	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
395965005675	phytoene desaturase; Region: crtI_fam; TIGR02734
395965005676	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395965005677	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
395965005678	substrate binding pocket [chemical binding]; other site
395965005679	chain length determination region; other site
395965005680	substrate-Mg2+ binding site; other site
395965005681	catalytic residues [active]
395965005682	aspartate-rich region 1; other site
395965005683	active site lid residues [active]
395965005684	aspartate-rich region 2; other site
395965005685	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
395965005686	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965005687	S-adenosylmethionine binding site [chemical binding]; other site
395965005688	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
395965005689	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
395965005690	putative NAD(P) binding site [chemical binding]; other site
395965005691	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395965005692	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
395965005693	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
395965005694	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
395965005695	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
395965005696	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
395965005697	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
395965005698	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
395965005699	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
395965005700	Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290
395965005701	subunit M interface; other site
395965005702	subunit H interface; other site
395965005703	quinone binding site; other site
395965005704	bacteriopheophytin binding site; other site
395965005705	bacteriochlorophyll binding site; other site
395965005706	cytochrome C subunit interface; other site
395965005707	Fe binding site [ion binding]; other site
395965005708	Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291
395965005709	subunit H interface; other site
395965005710	subunit L interface; other site
395965005711	bacteriopheophytin binding site; other site
395965005712	carotenoid binding site; other site
395965005713	bacteriochlorophyll binding site; other site
395965005714	cytochrome C interface; other site
395965005715	quinone binding site; other site
395965005716	Fe binding site [ion binding]; other site
395965005717	Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cd09224
395965005718	subunit interface [polypeptide binding]; other site
395965005719	Heme binding sites [chemical binding]; other site
395965005720	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
395965005721	UbiA prenyltransferase family; Region: UbiA; pfam01040
395965005722	PUCC protein; Region: PUCC; pfam03209
395965005723	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
395965005724	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395965005725	TspO/MBR family; Region: TspO_MBR; pfam03073
395965005726	putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056
395965005727	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395965005728	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
395965005729	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
395965005730	magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406
395965005731	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
395965005732	metal ion-dependent adhesion site (MIDAS); other site
395965005733	magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407
395965005734	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965005735	Walker A motif; other site
395965005736	ATP binding site [chemical binding]; other site
395965005737	Walker B motif; other site
395965005738	arginine finger; other site
395965005739	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
395965005740	active site lid residues [active]
395965005741	substrate binding pocket [chemical binding]; other site
395965005742	catalytic residues [active]
395965005743	substrate-Mg2+ binding site; other site
395965005744	aspartate-rich region 1; other site
395965005745	aspartate-rich region 2; other site
395965005746	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
395965005747	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
395965005748	homoserine dehydrogenase; Provisional; Region: PRK06349
395965005749	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
395965005750	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
395965005751	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
395965005752	active site
395965005753	hypothetical protein; Reviewed; Region: PRK00024
395965005754	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
395965005755	MPN+ (JAMM) motif; other site
395965005756	Zinc-binding site [ion binding]; other site
395965005757	Usg-like family; Region: Usg; pfam06233
395965005758	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
395965005759	Flavin Reductases; Region: FlaRed; cl00801
395965005760	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
395965005761	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
395965005762	TM-ABC transporter signature motif; other site
395965005763	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
395965005764	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
395965005765	TM-ABC transporter signature motif; other site
395965005766	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
395965005767	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
395965005768	Walker A/P-loop; other site
395965005769	ATP binding site [chemical binding]; other site
395965005770	Q-loop/lid; other site
395965005771	ABC transporter signature motif; other site
395965005772	Walker B; other site
395965005773	D-loop; other site
395965005774	H-loop/switch region; other site
395965005775	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
395965005776	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
395965005777	Walker A/P-loop; other site
395965005778	ATP binding site [chemical binding]; other site
395965005779	Q-loop/lid; other site
395965005780	ABC transporter signature motif; other site
395965005781	Walker B; other site
395965005782	D-loop; other site
395965005783	H-loop/switch region; other site
395965005784	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
395965005785	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
395965005786	dimerization interface [polypeptide binding]; other site
395965005787	ligand binding site [chemical binding]; other site
395965005788	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
395965005789	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
395965005790	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
395965005791	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
395965005792	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
395965005793	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965005794	S-adenosylmethionine binding site [chemical binding]; other site
395965005795	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
395965005796	putative heme binding pocket [chemical binding]; other site
395965005797	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
395965005798	integrase; Provisional; Region: PRK09692
395965005799	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
395965005800	active site
395965005801	Int/Topo IB signature motif; other site
395965005802	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
395965005803	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
395965005804	catalytic residues [active]
395965005805	catalytic nucleophile [active]
395965005806	Presynaptic Site I dimer interface [polypeptide binding]; other site
395965005807	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
395965005808	Synaptic Flat tetramer interface [polypeptide binding]; other site
395965005809	Synaptic Site I dimer interface [polypeptide binding]; other site
395965005810	DNA binding site [nucleotide binding]
395965005811	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
395965005812	DNA-binding interface [nucleotide binding]; DNA binding site
395965005813	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
395965005814	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
395965005815	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395965005816	motif II; other site
395965005817	ATP12 chaperone protein; Region: ATP12; cl02228
395965005818	Protein of unknown function (DUF461); Region: DUF461; pfam04314
395965005819	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
395965005820	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
395965005821	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395965005822	non-specific DNA binding site [nucleotide binding]; other site
395965005823	salt bridge; other site
395965005824	sequence-specific DNA binding site [nucleotide binding]; other site
395965005825	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
395965005826	Lumazine binding domain; Region: Lum_binding; pfam00677
395965005827	Lumazine binding domain; Region: Lum_binding; pfam00677
395965005828	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
395965005829	catalytic motif [active]
395965005830	Zn binding site [ion binding]; other site
395965005831	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
395965005832	RibD C-terminal domain; Region: RibD_C; cl17279
395965005833	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
395965005834	ATP cone domain; Region: ATP-cone; pfam03477
395965005835	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
395965005836	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
395965005837	dimer interface [polypeptide binding]; other site
395965005838	active site
395965005839	glycine-pyridoxal phosphate binding site [chemical binding]; other site
395965005840	folate binding site [chemical binding]; other site
395965005841	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
395965005842	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
395965005843	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395965005844	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395965005845	Transcriptional regulators [Transcription]; Region: MarR; COG1846
395965005846	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
395965005847	acetoacetate decarboxylase; Provisional; Region: PRK02265
395965005848	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
395965005849	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
395965005850	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
395965005851	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
395965005852	putative MPT binding site; other site
395965005853	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
395965005854	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
395965005855	RDD family; Region: RDD; pfam06271
395965005856	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
395965005857	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
395965005858	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
395965005859	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
395965005860	Protein kinase domain; Region: Pkinase; pfam00069
395965005861	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395965005862	active site
395965005863	ATP binding site [chemical binding]; other site
395965005864	substrate binding site [chemical binding]; other site
395965005865	activation loop (A-loop); other site
395965005866	Uncharacterized conserved protein [Function unknown]; Region: COG1262
395965005867	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
395965005868	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
395965005869	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
395965005870	CAP-like domain; other site
395965005871	active site
395965005872	primary dimer interface [polypeptide binding]; other site
395965005873	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395965005874	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395965005875	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
395965005876	NAD(P) binding site [chemical binding]; other site
395965005877	active site
395965005878	Predicted transcriptional regulators [Transcription]; Region: COG1733
395965005879	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395965005880	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
395965005881	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395965005882	inhibitor-cofactor binding pocket; inhibition site
395965005883	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965005884	catalytic residue [active]
395965005885	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395965005886	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
395965005887	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395965005888	catalytic residue [active]
395965005889	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
395965005890	AAA domain; Region: AAA_26; pfam13500
395965005891	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965005892	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965005893	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
395965005894	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
395965005895	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
395965005896	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
395965005897	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
395965005898	Walker A/P-loop; other site
395965005899	ATP binding site [chemical binding]; other site
395965005900	Q-loop/lid; other site
395965005901	ABC transporter signature motif; other site
395965005902	Walker B; other site
395965005903	D-loop; other site
395965005904	H-loop/switch region; other site
395965005905	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
395965005906	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965005907	dimer interface [polypeptide binding]; other site
395965005908	conserved gate region; other site
395965005909	ABC-ATPase subunit interface; other site
395965005910	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
395965005911	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
395965005912	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965005913	Walker A motif; other site
395965005914	ATP binding site [chemical binding]; other site
395965005915	Family description; Region: UvrD_C_2; pfam13538
395965005916	Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
395965005917	TMAO/DMSO reductase; Reviewed; Region: PRK05363
395965005918	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
395965005919	Moco binding site; other site
395965005920	metal coordination site [ion binding]; other site
395965005921	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
395965005922	hydrophobic ligand binding site; other site
395965005923	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
395965005924	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
395965005925	active site
395965005926	NTP binding site [chemical binding]; other site
395965005927	nucleic acid binding site [nucleotide binding]; other site
395965005928	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
395965005929	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395965005930	active site
395965005931	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
395965005932	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
395965005933	ribonuclease PH; Reviewed; Region: rph; PRK00173
395965005934	Ribonuclease PH; Region: RNase_PH_bact; cd11362
395965005935	hexamer interface [polypeptide binding]; other site
395965005936	active site
395965005937	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
395965005938	active site
395965005939	dimerization interface [polypeptide binding]; other site
395965005940	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
395965005941	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395965005942	FeS/SAM binding site; other site
395965005943	HemN C-terminal domain; Region: HemN_C; pfam06969
395965005944	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
395965005945	Peptidase M15; Region: Peptidase_M15_3; cl01194
395965005946	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
395965005947	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
395965005948	Domain of unknown function DUF20; Region: UPF0118; pfam01594
395965005949	hypothetical protein; Validated; Region: PRK09039
395965005950	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395965005951	ligand binding site [chemical binding]; other site
395965005952	hypothetical protein; Validated; Region: PRK08238
395965005953	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
395965005954	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
395965005955	GtrA-like protein; Region: GtrA; pfam04138
395965005956	FAD binding domain; Region: FAD_binding_4; pfam01565
395965005957	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
395965005958	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
395965005959	classical (c) SDRs; Region: SDR_c; cd05233
395965005960	NAD(P) binding site [chemical binding]; other site
395965005961	active site
395965005962	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
395965005963	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
395965005964	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395965005965	active site
395965005966	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
395965005967	ParB-like nuclease domain; Region: ParB; smart00470
395965005968	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
395965005969	HTH domain; Region: HTH_11; cl17392
395965005970	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
395965005971	Phage capsid family; Region: Phage_capsid; pfam05065
395965005972	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
395965005973	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
395965005974	Cupin; Region: Cupin_1; smart00835
395965005975	Cupin; Region: Cupin_1; smart00835
395965005976	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395965005977	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395965005978	DNA binding site [nucleotide binding]
395965005979	Predicted ATPase [General function prediction only]; Region: COG3903
395965005980	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
395965005981	pyruvate dehydrogenase; Provisional; Region: PRK09124
395965005982	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
395965005983	PYR/PP interface [polypeptide binding]; other site
395965005984	dimer interface [polypeptide binding]; other site
395965005985	TPP binding site [chemical binding]; other site
395965005986	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
395965005987	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
395965005988	TPP-binding site [chemical binding]; other site
395965005989	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
395965005990	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
395965005991	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
395965005992	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395965005993	Outer membrane efflux protein; Region: OEP; pfam02321
395965005994	Outer membrane efflux protein; Region: OEP; pfam02321
395965005995	multidrug efflux system protein MdtO; Provisional; Region: PRK11427
395965005996	multidrug resistance protein MdtN; Provisional; Region: PRK10476
395965005997	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965005998	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965005999	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
395965006000	putative metal binding site [ion binding]; other site
395965006001	hypothetical protein; Provisional; Region: PRK14709
395965006002	D5 N terminal like; Region: D5_N; smart00885
395965006003	CHC2 zinc finger; Region: zf-CHC2; cl17510
395965006004	Helix-turn-helix domain; Region: HTH_17; cl17695
395965006005	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
395965006006	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
395965006007	DNA binding residues [nucleotide binding]
395965006008	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
395965006009	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
395965006010	active site
395965006011	Int/Topo IB signature motif; other site
395965006012	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
395965006013	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
395965006014	NAD binding site [chemical binding]; other site
395965006015	homotetramer interface [polypeptide binding]; other site
395965006016	homodimer interface [polypeptide binding]; other site
395965006017	substrate binding site [chemical binding]; other site
395965006018	active site
395965006019	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
395965006020	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
395965006021	dimer interface [polypeptide binding]; other site
395965006022	active site
395965006023	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
395965006024	active site 1 [active]
395965006025	dimer interface [polypeptide binding]; other site
395965006026	active site 2 [active]
395965006027	Tim44-like domain; Region: Tim44; pfam04280
395965006028	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
395965006029	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395965006030	motif II; other site
395965006031	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
395965006032	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
395965006033	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
395965006034	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395965006035	ATP binding site [chemical binding]; other site
395965006036	putative Mg++ binding site [ion binding]; other site
395965006037	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395965006038	nucleotide binding region [chemical binding]; other site
395965006039	ATP-binding site [chemical binding]; other site
395965006040	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
395965006041	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
395965006042	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395965006043	dimerization interface [polypeptide binding]; other site
395965006044	putative DNA binding site [nucleotide binding]; other site
395965006045	putative Zn2+ binding site [ion binding]; other site
395965006046	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
395965006047	putative hydrophobic ligand binding site [chemical binding]; other site
395965006048	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900
395965006049	putative hydrophobic ligand binding site [chemical binding]; other site
395965006050	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
395965006051	dimer interface [polypeptide binding]; other site
395965006052	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
395965006053	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395965006054	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395965006055	Walker A/P-loop; other site
395965006056	ATP binding site [chemical binding]; other site
395965006057	Q-loop/lid; other site
395965006058	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395965006059	ABC transporter signature motif; other site
395965006060	Walker B; other site
395965006061	D-loop; other site
395965006062	ABC transporter; Region: ABC_tran_2; pfam12848
395965006063	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
395965006064	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
395965006065	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
395965006066	ssDNA binding site; other site
395965006067	generic binding surface II; other site
395965006068	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395965006069	ATP binding site [chemical binding]; other site
395965006070	putative Mg++ binding site [ion binding]; other site
395965006071	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395965006072	nucleotide binding region [chemical binding]; other site
395965006073	ATP-binding site [chemical binding]; other site
395965006074	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395965006075	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965006076	putative substrate translocation pore; other site
395965006077	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965006078	S-adenosylmethionine binding site [chemical binding]; other site
395965006079	DNA polymerase III subunit chi; Validated; Region: PRK05728
395965006080	multifunctional aminopeptidase A; Provisional; Region: PRK00913
395965006081	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
395965006082	interface (dimer of trimers) [polypeptide binding]; other site
395965006083	Substrate-binding/catalytic site; other site
395965006084	Zn-binding sites [ion binding]; other site
395965006085	Predicted permeases [General function prediction only]; Region: COG0795
395965006086	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
395965006087	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
395965006088	Organic solvent tolerance protein; Region: OstA_C; pfam04453
395965006089	SurA N-terminal domain; Region: SurA_N_3; cl07813
395965006090	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
395965006091	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
395965006092	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
395965006093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965006094	S-adenosylmethionine binding site [chemical binding]; other site
395965006095	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
395965006096	active site
395965006097	oxyanion hole [active]
395965006098	catalytic triad [active]
395965006099	OpgC protein; Region: OpgC_C; pfam10129
395965006100	Uncharacterized conserved protein [Function unknown]; Region: COG0062
395965006101	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
395965006102	putative substrate binding site [chemical binding]; other site
395965006103	putative ATP binding site [chemical binding]; other site
395965006104	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
395965006105	Ion channel; Region: Ion_trans_2; pfam07885
395965006106	DNA gyrase, A subunit; Region: gyrA; TIGR01063
395965006107	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
395965006108	CAP-like domain; other site
395965006109	active site
395965006110	primary dimer interface [polypeptide binding]; other site
395965006111	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395965006112	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395965006113	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395965006114	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395965006115	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
395965006116	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
395965006117	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
395965006118	dimer interface [polypeptide binding]; other site
395965006119	ssDNA binding site [nucleotide binding]; other site
395965006120	tetramer (dimer of dimers) interface [polypeptide binding]; other site
395965006121	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
395965006122	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
395965006123	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
395965006124	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
395965006125	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
395965006126	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
395965006127	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
395965006128	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965006129	S-adenosylmethionine binding site [chemical binding]; other site
395965006130	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
395965006131	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
395965006132	RNA binding surface [nucleotide binding]; other site
395965006133	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
395965006134	active site
395965006135	uracil binding [chemical binding]; other site
395965006136	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
395965006137	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965006138	S-adenosylmethionine binding site [chemical binding]; other site
395965006139	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
395965006140	ABC1 family; Region: ABC1; cl17513
395965006141	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
395965006142	Flavoprotein; Region: Flavoprotein; pfam02441
395965006143	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
395965006144	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
395965006145	trimer interface [polypeptide binding]; other site
395965006146	active site
395965006147	Transcriptional regulator; Region: Rrf2; pfam02082
395965006148	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
395965006149	putative FMN binding site [chemical binding]; other site
395965006150	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
395965006151	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
395965006152	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
395965006153	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
395965006154	TOBE domain; Region: TOBE; cl01440
395965006155	TOBE domain; Region: TOBE; cl01440
395965006156	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
395965006157	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
395965006158	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
395965006159	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
395965006160	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
395965006161	motif II; other site
395965006162	ATP-NAD kinase; Region: NAD_kinase; pfam01513
395965006163	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
395965006164	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
395965006165	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
395965006166	dimer interface [polypeptide binding]; other site
395965006167	ADP-ribose binding site [chemical binding]; other site
395965006168	active site
395965006169	nudix motif; other site
395965006170	metal binding site [ion binding]; metal-binding site
395965006171	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
395965006172	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965006173	putative substrate translocation pore; other site
395965006174	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
395965006175	Protein of unknown function (DUF1192); Region: DUF1192; pfam06698
395965006176	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
395965006177	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
395965006178	Trp docking motif [polypeptide binding]; other site
395965006179	active site
395965006180	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
395965006181	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395965006182	active site
395965006183	metal binding site [ion binding]; metal-binding site
395965006184	DNA binding site [nucleotide binding]
395965006185	AAA domain; Region: AAA_27; pfam13514
395965006186	AAA domain; Region: AAA_27; pfam13514
395965006187	putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325
395965006188	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
395965006189	active site
395965006190	metal binding site [ion binding]; metal-binding site
395965006191	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395965006192	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
395965006193	diiron binding motif [ion binding]; other site
395965006194	Uncharacterized conserved protein [Function unknown]; Region: COG1633
395965006195	CCC1-related family of proteins; Region: CCC1_like; cl00278
395965006196	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
395965006197	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395965006198	Coenzyme A binding pocket [chemical binding]; other site
395965006199	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
395965006200	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395965006201	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965006202	active site
395965006203	phosphorylation site [posttranslational modification]
395965006204	intermolecular recognition site; other site
395965006205	dimerization interface [polypeptide binding]; other site
395965006206	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395965006207	DNA binding residues [nucleotide binding]
395965006208	dimerization interface [polypeptide binding]; other site
395965006209	HAMP domain; Region: HAMP; pfam00672
395965006210	dimerization interface [polypeptide binding]; other site
395965006211	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
395965006212	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965006213	ATP binding site [chemical binding]; other site
395965006214	Mg2+ binding site [ion binding]; other site
395965006215	G-X-G motif; other site
395965006216	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
395965006217	active site
395965006218	DNA binding site [nucleotide binding]
395965006219	SnoaL-like domain; Region: SnoaL_2; pfam12680
395965006220	multicopper oxidase; Provisional; Region: PRK10965
395965006221	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
395965006222	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
395965006223	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
395965006224	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395965006225	putative active site [active]
395965006226	metal binding site [ion binding]; metal-binding site
395965006227	homodimer binding site [polypeptide binding]; other site
395965006228	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
395965006229	Cell division protein ZapA; Region: ZapA; pfam05164
395965006230	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
395965006231	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
395965006232	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
395965006233	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
395965006234	Phosphoglycerate kinase; Region: PGK; pfam00162
395965006235	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
395965006236	substrate binding site [chemical binding]; other site
395965006237	hinge regions; other site
395965006238	ADP binding site [chemical binding]; other site
395965006239	catalytic site [active]
395965006240	Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613
395965006241	TPR repeat; Region: TPR_11; pfam13414
395965006242	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965006243	binding surface
395965006244	TPR motif; other site
395965006245	TPR repeat; Region: TPR_11; pfam13414
395965006246	TPR repeat; Region: TPR_11; pfam13414
395965006247	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965006248	binding surface
395965006249	TPR motif; other site
395965006250	TPR repeat; Region: TPR_11; pfam13414
395965006251	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
395965006252	phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161
395965006253	ATP-grasp domain; Region: ATP-grasp; pfam02222
395965006254	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
395965006255	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395965006256	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395965006257	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395965006258	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395965006259	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
395965006260	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
395965006261	RNA binding site [nucleotide binding]; other site
395965006262	active site
395965006263	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
395965006264	translation initiation factor IF-2; Region: IF-2; TIGR00487
395965006265	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
395965006266	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
395965006267	G1 box; other site
395965006268	putative GEF interaction site [polypeptide binding]; other site
395965006269	GTP/Mg2+ binding site [chemical binding]; other site
395965006270	Switch I region; other site
395965006271	G2 box; other site
395965006272	G3 box; other site
395965006273	Switch II region; other site
395965006274	G4 box; other site
395965006275	G5 box; other site
395965006276	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
395965006277	Translation-initiation factor 2; Region: IF-2; pfam11987
395965006278	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
395965006279	hypothetical protein; Provisional; Region: PRK09190
395965006280	Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740
395965006281	putative RNA binding cleft [nucleotide binding]; other site
395965006282	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
395965006283	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
395965006284	NusA N-terminal domain; Region: NusA_N; pfam08529
395965006285	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
395965006286	RNA binding site [nucleotide binding]; other site
395965006287	homodimer interface [polypeptide binding]; other site
395965006288	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
395965006289	G-X-X-G motif; other site
395965006290	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
395965006291	G-X-X-G motif; other site
395965006292	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
395965006293	ribosome maturation protein RimP; Reviewed; Region: PRK00092
395965006294	Sm and related proteins; Region: Sm_like; cl00259
395965006295	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
395965006296	putative oligomer interface [polypeptide binding]; other site
395965006297	putative RNA binding site [nucleotide binding]; other site
395965006298	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
395965006299	dimer interface [polypeptide binding]; other site
395965006300	Alkaline phosphatase homologues; Region: alkPPc; smart00098
395965006301	active site
395965006302	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
395965006303	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
395965006304	Uncharacterized conserved protein [Function unknown]; Region: COG2308
395965006305	Fasciclin domain; Region: Fasciclin; pfam02469
395965006306	hypothetical protein; Validated; Region: PRK00110
395965006307	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
395965006308	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
395965006309	C-terminal domain interface [polypeptide binding]; other site
395965006310	GSH binding site (G-site) [chemical binding]; other site
395965006311	dimer interface [polypeptide binding]; other site
395965006312	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
395965006313	N-terminal domain interface [polypeptide binding]; other site
395965006314	putative dimer interface [polypeptide binding]; other site
395965006315	active site
395965006316	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
395965006317	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
395965006318	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395965006319	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395965006320	DNA binding residues [nucleotide binding]
395965006321	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
395965006322	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395965006323	RNA binding surface [nucleotide binding]; other site
395965006324	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
395965006325	active site
395965006326	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
395965006327	Fructosamine kinase; Region: Fructosamin_kin; cl17579
395965006328	Low molecular weight phosphatase family; Region: LMWPc; cd00115
395965006329	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
395965006330	active site
395965006331	Putative catalytic NodB homology domain of uncharacterized protein RC0012 from Rickettsia conorii and its bacterial homologs; Region: CE4_RC0012_like; cd10963
395965006332	NodB motif; other site
395965006333	putative active site [active]
395965006334	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395965006335	Coenzyme A binding pocket [chemical binding]; other site
395965006336	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
395965006337	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
395965006338	Domain of unknown function DUF21; Region: DUF21; pfam01595
395965006339	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
395965006340	Transporter associated domain; Region: CorC_HlyC; smart01091
395965006341	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
395965006342	Shikimate kinase; Region: SKI; pfam01202
395965006343	ADP binding site [chemical binding]; other site
395965006344	magnesium binding site [ion binding]; other site
395965006345	putative shikimate binding site; other site
395965006346	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
395965006347	active site
395965006348	dimer interface [polypeptide binding]; other site
395965006349	metal binding site [ion binding]; metal-binding site
395965006350	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
395965006351	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
395965006352	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
395965006353	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
395965006354	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395965006355	putative ADP-binding pocket [chemical binding]; other site
395965006356	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965006357	TPR motif; other site
395965006358	binding surface
395965006359	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
395965006360	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965006361	binding surface
395965006362	TPR motif; other site
395965006363	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965006364	binding surface
395965006365	TPR motif; other site
395965006366	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965006367	binding surface
395965006368	TPR motif; other site
395965006369	TPR repeat; Region: TPR_11; pfam13414
395965006370	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965006371	binding surface
395965006372	TPR motif; other site
395965006373	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395965006374	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395965006375	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965006376	active site
395965006377	phosphorylation site [posttranslational modification]
395965006378	intermolecular recognition site; other site
395965006379	dimerization interface [polypeptide binding]; other site
395965006380	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
395965006381	Transcriptional regulators [Transcription]; Region: MarR; COG1846
395965006382	MarR family; Region: MarR; pfam01047
395965006383	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
395965006384	MutS domain I; Region: MutS_I; pfam01624
395965006385	MutS domain II; Region: MutS_II; pfam05188
395965006386	MutS domain III; Region: MutS_III; pfam05192
395965006387	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
395965006388	Walker A/P-loop; other site
395965006389	ATP binding site [chemical binding]; other site
395965006390	Q-loop/lid; other site
395965006391	ABC transporter signature motif; other site
395965006392	Walker B; other site
395965006393	D-loop; other site
395965006394	H-loop/switch region; other site
395965006395	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
395965006396	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
395965006397	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
395965006398	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
395965006399	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
395965006400	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395965006401	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965006402	ATP binding site [chemical binding]; other site
395965006403	Mg2+ binding site [ion binding]; other site
395965006404	G-X-G motif; other site
395965006405	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395965006406	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395965006407	ligand binding site [chemical binding]; other site
395965006408	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
395965006409	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395965006410	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395965006411	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
395965006412	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
395965006413	TrkA-N domain; Region: TrkA_N; pfam02254
395965006414	Predicted membrane protein [Function unknown]; Region: COG4270
395965006415	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
395965006416	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
395965006417	active site
395965006418	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
395965006419	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395965006420	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
395965006421	putative active site [active]
395965006422	putative metal binding site [ion binding]; other site
395965006423	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
395965006424	Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022
395965006425	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
395965006426	Uncharacterized conserved protein [Function unknown]; Region: COG3287
395965006427	FIST N domain; Region: FIST; pfam08495
395965006428	FIST C domain; Region: FIST_C; pfam10442
395965006429	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395965006430	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965006431	dimer interface [polypeptide binding]; other site
395965006432	phosphorylation site [posttranslational modification]
395965006433	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965006434	ATP binding site [chemical binding]; other site
395965006435	Mg2+ binding site [ion binding]; other site
395965006436	G-X-G motif; other site
395965006437	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395965006438	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965006439	active site
395965006440	phosphorylation site [posttranslational modification]
395965006441	intermolecular recognition site; other site
395965006442	dimerization interface [polypeptide binding]; other site
395965006443	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395965006444	DNA binding residues [nucleotide binding]
395965006445	dimerization interface [polypeptide binding]; other site
395965006446	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
395965006447	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395965006448	NAD(P) binding site [chemical binding]; other site
395965006449	catalytic residues [active]
395965006450	PRC-barrel domain; Region: PRC; pfam05239
395965006451	PRC-barrel domain; Region: PRC; pfam05239
395965006452	Phasin protein; Region: Phasin_2; cl11491
395965006453	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
395965006454	metal binding site 2 [ion binding]; metal-binding site
395965006455	putative DNA binding helix; other site
395965006456	metal binding site 1 [ion binding]; metal-binding site
395965006457	dimer interface [polypeptide binding]; other site
395965006458	structural Zn2+ binding site [ion binding]; other site
395965006459	Peptidase family M48; Region: Peptidase_M48; pfam01435
395965006460	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
395965006461	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
395965006462	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395965006463	active site
395965006464	ATP binding site [chemical binding]; other site
395965006465	substrate binding site [chemical binding]; other site
395965006466	activation loop (A-loop); other site
395965006467	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
395965006468	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
395965006469	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
395965006470	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
395965006471	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
395965006472	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
395965006473	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
395965006474	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395965006475	ligand binding site [chemical binding]; other site
395965006476	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
395965006477	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
395965006478	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395965006479	phosphopeptide binding site; other site
395965006480	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
395965006481	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
395965006482	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
395965006483	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
395965006484	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
395965006485	putative active site [active]
395965006486	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
395965006487	Protein of unknown function (DUF770); Region: DUF770; pfam05591
395965006488	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
395965006489	Protein of unknown function (DUF877); Region: DUF877; pfam05943
395965006490	Protein of unknown function (DUF796); Region: DUF796; pfam05638
395965006491	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
395965006492	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
395965006493	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
395965006494	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
395965006495	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
395965006496	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965006497	Walker A motif; other site
395965006498	ATP binding site [chemical binding]; other site
395965006499	Walker B motif; other site
395965006500	arginine finger; other site
395965006501	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965006502	Walker A motif; other site
395965006503	ATP binding site [chemical binding]; other site
395965006504	Walker B motif; other site
395965006505	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
395965006506	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395965006507	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965006508	S-adenosylmethionine binding site [chemical binding]; other site
395965006509	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
395965006510	Caspase domain; Region: Peptidase_C14; pfam00656
395965006511	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
395965006512	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
395965006513	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395965006514	ligand binding site [chemical binding]; other site
395965006515	PAAR motif; Region: PAAR_motif; pfam05488
395965006516	Domain of unknown function (DUF4424); Region: DUF4424; pfam14415
395965006517	Carboxylesterase family; Region: COesterase; pfam00135
395965006518	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
395965006519	substrate binding pocket [chemical binding]; other site
395965006520	catalytic triad [active]
395965006521	TraB family; Region: TraB; pfam01963
395965006522	Autotransporter beta-domain; Region: Autotransporter; cl17461
395965006523	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965006524	TPR repeat; Region: TPR_11; pfam13414
395965006525	binding surface
395965006526	TPR motif; other site
395965006527	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965006528	binding surface
395965006529	TPR motif; other site
395965006530	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
395965006531	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965006532	binding surface
395965006533	TPR motif; other site
395965006534	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965006535	binding surface
395965006536	TPR motif; other site
395965006537	Caspase domain; Region: Peptidase_C14; pfam00656
395965006538	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
395965006539	glutathione s-transferase; Provisional; Region: PTZ00057
395965006540	GSH binding site (G-site) [chemical binding]; other site
395965006541	C-terminal domain interface [polypeptide binding]; other site
395965006542	dimer interface [polypeptide binding]; other site
395965006543	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
395965006544	dimer interface [polypeptide binding]; other site
395965006545	N-terminal domain interface [polypeptide binding]; other site
395965006546	substrate binding pocket (H-site) [chemical binding]; other site
395965006547	Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907
395965006548	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
395965006549	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
395965006550	NAD(P) binding pocket [chemical binding]; other site
395965006551	Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232
395965006552	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395965006553	N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264
395965006554	Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria.  It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545
395965006555	trimer interface I [polypeptide binding]; other site
395965006556	putative substrate binding pocket [chemical binding]; other site
395965006557	trimer interface II [polypeptide binding]; other site
395965006558	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395965006559	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874
395965006560	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
395965006561	hisA/hisF family protein; Region: hisAF_rel; TIGR00734
395965006562	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
395965006563	active site
395965006564	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
395965006565	nucleotide binding site [chemical binding]; other site
395965006566	Protein of unknown function (DUF447); Region: DUF447; pfam04289
395965006567	dihydropteroate synthase-related protein; Region: TIGR00284
395965006568	Protein of unknown function (DUF512); Region: DUF512; pfam04459
395965006569	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
395965006570	substrate binding pocket [chemical binding]; other site
395965006571	dimer interface [polypeptide binding]; other site
395965006572	inhibitor binding site; inhibition site
395965006573	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
395965006574	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
395965006575	substrate binding site [chemical binding]; other site
395965006576	nucleotide binding site [chemical binding]; other site
395965006577	hypothetical protein; Provisional; Region: PRK02227
395965006578	Dihydroneopterin aldolase; Region: FolB; pfam02152
395965006579	active site
395965006580	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
395965006581	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
395965006582	glutamine binding [chemical binding]; other site
395965006583	catalytic triad [active]
395965006584	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
395965006585	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
395965006586	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
395965006587	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
395965006588	molybdopterin cofactor binding site; other site
395965006589	formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121
395965006590	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
395965006591	active site
395965006592	formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114
395965006593	Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913
395965006594	FTR, proximal lobe; Region: FTR_C; pfam02741
395965006595	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
395965006596	domain_subunit interface; other site
395965006597	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
395965006598	aromatic arch; other site
395965006599	DCoH dimer interaction site [polypeptide binding]; other site
395965006600	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
395965006601	DCoH tetramer interaction site [polypeptide binding]; other site
395965006602	substrate binding site [chemical binding]; other site
395965006603	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
395965006604	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
395965006605	Walker A/P-loop; other site
395965006606	ATP binding site [chemical binding]; other site
395965006607	Q-loop/lid; other site
395965006608	ABC transporter signature motif; other site
395965006609	Walker B; other site
395965006610	D-loop; other site
395965006611	H-loop/switch region; other site
395965006612	ABC-2 type transporter; Region: ABC2_membrane; cl17235
395965006613	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
395965006614	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
395965006615	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
395965006616	Cl- selectivity filter; other site
395965006617	Cl- binding residues [ion binding]; other site
395965006618	pore gating glutamate residue; other site
395965006619	dimer interface [polypeptide binding]; other site
395965006620	H+/Cl- coupling transport residue; other site
395965006621	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
395965006622	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
395965006623	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
395965006624	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
395965006625	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
395965006626	ethanolamine permease; Region: 2A0305; TIGR00908
395965006627	Protein required for attachment to host cells; Region: Host_attach; pfam10116
395965006628	putative oxidoreductase; Provisional; Region: PRK09939
395965006629	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
395965006630	putative molybdopterin cofactor binding site [chemical binding]; other site
395965006631	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
395965006632	putative molybdopterin cofactor binding site; other site
395965006633	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965006634	enterobactin exporter EntS; Provisional; Region: PRK10489
395965006635	putative substrate translocation pore; other site
395965006636	serine O-acetyltransferase; Region: cysE; TIGR01172
395965006637	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
395965006638	trimer interface [polypeptide binding]; other site
395965006639	active site
395965006640	substrate binding site [chemical binding]; other site
395965006641	CoA binding site [chemical binding]; other site
395965006642	Predicted permeases [General function prediction only]; Region: COG0679
395965006643	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
395965006644	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
395965006645	oligomer interface [polypeptide binding]; other site
395965006646	metal binding site [ion binding]; metal-binding site
395965006647	metal binding site [ion binding]; metal-binding site
395965006648	putative Cl binding site [ion binding]; other site
395965006649	basic sphincter; other site
395965006650	hydrophobic gate; other site
395965006651	periplasmic entrance; other site
395965006652	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
395965006653	putative active site [active]
395965006654	sulfite reductase subunit beta; Provisional; Region: PRK13504
395965006655	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395965006656	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395965006657	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
395965006658	Flavodoxin; Region: Flavodoxin_1; pfam00258
395965006659	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
395965006660	FAD binding pocket [chemical binding]; other site
395965006661	FAD binding motif [chemical binding]; other site
395965006662	catalytic residues [active]
395965006663	NAD binding pocket [chemical binding]; other site
395965006664	phosphate binding motif [ion binding]; other site
395965006665	beta-alpha-beta structure motif; other site
395965006666	L-lactate permease; Region: Lactate_perm; cl00701
395965006667	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
395965006668	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
395965006669	Cysteine-rich domain; Region: CCG; pfam02754
395965006670	Cysteine-rich domain; Region: CCG; pfam02754
395965006671	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
395965006672	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
395965006673	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
395965006674	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
395965006675	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
395965006676	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965006677	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965006678	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
395965006679	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
395965006680	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965006681	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965006682	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
395965006683	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965006684	putative substrate translocation pore; other site
395965006685	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965006686	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
395965006687	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
395965006688	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
395965006689	catalytic core [active]
395965006690	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
395965006691	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
395965006692	putative NAD(P) binding site [chemical binding]; other site
395965006693	putative substrate binding site [chemical binding]; other site
395965006694	catalytic Zn binding site [ion binding]; other site
395965006695	structural Zn binding site [ion binding]; other site
395965006696	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
395965006697	Mechanosensitive ion channel; Region: MS_channel; pfam00924
395965006698	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395965006699	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395965006700	ligand binding site [chemical binding]; other site
395965006701	flexible hinge region; other site
395965006702	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
395965006703	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965006704	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965006705	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
395965006706	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395965006707	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395965006708	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965006709	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395965006710	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395965006711	active site
395965006712	catalytic tetrad [active]
395965006713	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
395965006714	NMT1-like family; Region: NMT1_2; pfam13379
395965006715	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395965006716	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
395965006717	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395965006718	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395965006719	Walker A/P-loop; other site
395965006720	ATP binding site [chemical binding]; other site
395965006721	Q-loop/lid; other site
395965006722	ABC transporter signature motif; other site
395965006723	Walker B; other site
395965006724	D-loop; other site
395965006725	H-loop/switch region; other site
395965006726	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
395965006727	formate dehydrogenase; Provisional; Region: PRK07574
395965006728	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
395965006729	dimerization interface [polypeptide binding]; other site
395965006730	ligand binding site [chemical binding]; other site
395965006731	NAD binding site [chemical binding]; other site
395965006732	catalytic site [active]
395965006733	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395965006734	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965006735	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
395965006736	dimerization interface [polypeptide binding]; other site
395965006737	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
395965006738	catalytic residues [active]
395965006739	dimer interface [polypeptide binding]; other site
395965006740	Dodecin; Region: Dodecin; pfam07311
395965006741	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395965006742	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395965006743	ligand binding site [chemical binding]; other site
395965006744	flexible hinge region; other site
395965006745	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
395965006746	nucleophile elbow; other site
395965006747	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
395965006748	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
395965006749	Predicted transcriptional regulators [Transcription]; Region: COG1733
395965006750	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395965006751	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
395965006752	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395965006753	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
395965006754	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395965006755	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
395965006756	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395965006757	catalytic loop [active]
395965006758	iron binding site [ion binding]; other site
395965006759	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
395965006760	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395965006761	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395965006762	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965006763	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
395965006764	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
395965006765	tetramer interface [polypeptide binding]; other site
395965006766	heme binding pocket [chemical binding]; other site
395965006767	NADPH binding site [chemical binding]; other site
395965006768	Oxygen tolerance; Region: BatD; pfam13584
395965006769	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965006770	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395965006771	TPR motif; other site
395965006772	binding surface
395965006773	von Willebrand factor type A domain; Region: VWA_2; pfam13519
395965006774	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
395965006775	metal ion-dependent adhesion site (MIDAS); other site
395965006776	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
395965006777	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
395965006778	Protein of unknown function DUF58; Region: DUF58; pfam01882
395965006779	MoxR-like ATPases [General function prediction only]; Region: COG0714
395965006780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965006781	Walker A motif; other site
395965006782	ATP binding site [chemical binding]; other site
395965006783	Walker B motif; other site
395965006784	arginine finger; other site
395965006785	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
395965006786	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395965006787	dimerization interface [polypeptide binding]; other site
395965006788	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395965006789	dimerization interface [polypeptide binding]; other site
395965006790	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395965006791	dimerization interface [polypeptide binding]; other site
395965006792	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
395965006793	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395965006794	dimerization interface [polypeptide binding]; other site
395965006795	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395965006796	dimerization interface [polypeptide binding]; other site
395965006797	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395965006798	dimerization interface [polypeptide binding]; other site
395965006799	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395965006800	dimerization interface [polypeptide binding]; other site
395965006801	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
395965006802	dimerization interface [polypeptide binding]; other site
395965006803	GAF domain; Region: GAF_2; pfam13185
395965006804	GAF domain; Region: GAF; pfam01590
395965006805	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395965006806	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965006807	dimer interface [polypeptide binding]; other site
395965006808	phosphorylation site [posttranslational modification]
395965006809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965006810	ATP binding site [chemical binding]; other site
395965006811	Mg2+ binding site [ion binding]; other site
395965006812	G-X-G motif; other site
395965006813	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395965006814	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965006815	active site
395965006816	phosphorylation site [posttranslational modification]
395965006817	intermolecular recognition site; other site
395965006818	dimerization interface [polypeptide binding]; other site
395965006819	Response regulator receiver domain; Region: Response_reg; pfam00072
395965006820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965006821	active site
395965006822	phosphorylation site [posttranslational modification]
395965006823	intermolecular recognition site; other site
395965006824	dimerization interface [polypeptide binding]; other site
395965006825	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965006826	dimer interface [polypeptide binding]; other site
395965006827	phosphorylation site [posttranslational modification]
395965006828	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965006829	ATP binding site [chemical binding]; other site
395965006830	Mg2+ binding site [ion binding]; other site
395965006831	G-X-G motif; other site
395965006832	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965006833	active site
395965006834	phosphorylation site [posttranslational modification]
395965006835	intermolecular recognition site; other site
395965006836	dimerization interface [polypeptide binding]; other site
395965006837	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
395965006838	Domain of unknown function DUF21; Region: DUF21; pfam01595
395965006839	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
395965006840	Transporter associated domain; Region: CorC_HlyC; smart01091
395965006841	hypothetical protein; Validated; Region: PRK07581
395965006842	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
395965006843	Protein of unknown function (DUF938); Region: DUF938; pfam06080
395965006844	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395965006845	NAD(P) binding site [chemical binding]; other site
395965006846	active site
395965006847	Putative mono-oxygenase ydhR; Region: ydhR; cl07420
395965006848	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
395965006849	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395965006850	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395965006851	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
395965006852	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
395965006853	dimerization interface [polypeptide binding]; other site
395965006854	ligand binding site [chemical binding]; other site
395965006855	NADP binding site [chemical binding]; other site
395965006856	catalytic site [active]
395965006857	Bacterial SH3 domain; Region: SH3_4; pfam06347
395965006858	Bacterial SH3 domain; Region: SH3_4; pfam06347
395965006859	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
395965006860	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
395965006861	dimer interface [polypeptide binding]; other site
395965006862	active site
395965006863	CoA binding pocket [chemical binding]; other site
395965006864	hypothetical protein; Provisional; Region: PRK10621
395965006865	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
395965006866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395965006867	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395965006868	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
395965006869	iron-sulfur cluster [ion binding]; other site
395965006870	[2Fe-2S] cluster binding site [ion binding]; other site
395965006871	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395965006872	MarR family; Region: MarR_2; pfam12802
395965006873	Predicted ATPase [General function prediction only]; Region: COG1485
395965006874	malate dehydrogenase; Reviewed; Region: PRK06223
395965006875	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
395965006876	NAD(P) binding site [chemical binding]; other site
395965006877	dimer interface [polypeptide binding]; other site
395965006878	tetramer (dimer of dimers) interface [polypeptide binding]; other site
395965006879	substrate binding site [chemical binding]; other site
395965006880	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
395965006881	CoA binding domain; Region: CoA_binding; pfam02629
395965006882	CoA-ligase; Region: Ligase_CoA; pfam00549
395965006883	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
395965006884	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
395965006885	TPP-binding site [chemical binding]; other site
395965006886	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
395965006887	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
395965006888	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395965006889	E3 interaction surface; other site
395965006890	lipoyl attachment site [posttranslational modification]; other site
395965006891	e3 binding domain; Region: E3_binding; pfam02817
395965006892	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
395965006893	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
395965006894	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
395965006895	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395965006896	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395965006897	branched-chain amino acid aminotransferase; Validated; Region: PRK07544
395965006898	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
395965006899	homodimer interface [polypeptide binding]; other site
395965006900	substrate-cofactor binding pocket; other site
395965006901	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965006902	catalytic residue [active]
395965006903	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
395965006904	MarR family; Region: MarR_2; pfam12802
395965006905	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395965006906	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965006907	active site
395965006908	phosphorylation site [posttranslational modification]
395965006909	intermolecular recognition site; other site
395965006910	dimerization interface [polypeptide binding]; other site
395965006911	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395965006912	DNA binding site [nucleotide binding]
395965006913	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395965006914	HAMP domain; Region: HAMP; pfam00672
395965006915	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965006916	dimer interface [polypeptide binding]; other site
395965006917	phosphorylation site [posttranslational modification]
395965006918	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965006919	ATP binding site [chemical binding]; other site
395965006920	Mg2+ binding site [ion binding]; other site
395965006921	G-X-G motif; other site
395965006922	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
395965006923	heme-binding site [chemical binding]; other site
395965006924	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
395965006925	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395965006926	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395965006927	metal binding site [ion binding]; metal-binding site
395965006928	active site
395965006929	I-site; other site
395965006930	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395965006931	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395965006932	metal binding site [ion binding]; metal-binding site
395965006933	active site
395965006934	I-site; other site
395965006935	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
395965006936	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
395965006937	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395965006938	Walker A/P-loop; other site
395965006939	ATP binding site [chemical binding]; other site
395965006940	Q-loop/lid; other site
395965006941	ABC transporter signature motif; other site
395965006942	Walker B; other site
395965006943	D-loop; other site
395965006944	H-loop/switch region; other site
395965006945	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
395965006946	active site
395965006947	8-oxo-dGMP binding site [chemical binding]; other site
395965006948	nudix motif; other site
395965006949	metal binding site [ion binding]; metal-binding site
395965006950	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
395965006951	heterotetramer interface [polypeptide binding]; other site
395965006952	active site pocket [active]
395965006953	cleavage site
395965006954	Novel bacterial esterase 713 that cleaves esters on halogenated cyclic compounds; Region: Esterase_713; cd12807
395965006955	catalytic site [active]
395965006956	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
395965006957	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
395965006958	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
395965006959	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
395965006960	SEC-C motif; Region: SEC-C; pfam02810
395965006961	Predicted integral membrane protein [Function unknown]; Region: COG0392
395965006962	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395965006963	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965006964	active site
395965006965	phosphorylation site [posttranslational modification]
395965006966	intermolecular recognition site; other site
395965006967	dimerization interface [polypeptide binding]; other site
395965006968	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395965006969	DNA binding site [nucleotide binding]
395965006970	Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090
395965006971	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395965006972	sequence-specific DNA binding site [nucleotide binding]; other site
395965006973	salt bridge; other site
395965006974	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
395965006975	Domain of unknown function (DUF955); Region: DUF955; pfam06114
395965006976	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
395965006977	transcription termination factor Rho; Provisional; Region: rho; PRK09376
395965006978	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
395965006979	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
395965006980	RNA binding site [nucleotide binding]; other site
395965006981	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
395965006982	multimer interface [polypeptide binding]; other site
395965006983	Walker A motif; other site
395965006984	ATP binding site [chemical binding]; other site
395965006985	Walker B motif; other site
395965006986	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
395965006987	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
395965006988	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
395965006989	substrate binding site [chemical binding]; other site
395965006990	active site
395965006991	PEP synthetase regulatory protein; Provisional; Region: PRK05339
395965006992	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
395965006993	putative active site [active]
395965006994	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
395965006995	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
395965006996	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
395965006997	NAD(P) binding site [chemical binding]; other site
395965006998	shikimate binding site; other site
395965006999	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
395965007000	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
395965007001	CoA-binding site [chemical binding]; other site
395965007002	ATP-binding [chemical binding]; other site
395965007003	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
395965007004	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
395965007005	active site
395965007006	catalytic site [active]
395965007007	substrate binding site [chemical binding]; other site
395965007008	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
395965007009	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
395965007010	Cysteine-rich domain; Region: CCG; pfam02754
395965007011	Cysteine-rich domain; Region: CCG; pfam02754
395965007012	FAD binding domain; Region: FAD_binding_4; pfam01565
395965007013	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
395965007014	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
395965007015	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
395965007016	putative hydrophobic ligand binding site [chemical binding]; other site
395965007017	protein interface [polypeptide binding]; other site
395965007018	gate; other site
395965007019	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
395965007020	putative hydrophobic ligand binding site [chemical binding]; other site
395965007021	protein interface [polypeptide binding]; other site
395965007022	gate; other site
395965007023	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
395965007024	Predicted transcriptional regulator [Transcription]; Region: COG2944
395965007025	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395965007026	non-specific DNA binding site [nucleotide binding]; other site
395965007027	salt bridge; other site
395965007028	sequence-specific DNA binding site [nucleotide binding]; other site
395965007029	pantothenate kinase; Provisional; Region: PRK05439
395965007030	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
395965007031	ATP-binding site [chemical binding]; other site
395965007032	CoA-binding site [chemical binding]; other site
395965007033	Mg2+-binding site [ion binding]; other site
395965007034	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
395965007035	metal binding site [ion binding]; metal-binding site
395965007036	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
395965007037	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
395965007038	substrate binding site [chemical binding]; other site
395965007039	glutamase interaction surface [polypeptide binding]; other site
395965007040	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
395965007041	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
395965007042	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
395965007043	catalytic residues [active]
395965007044	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
395965007045	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
395965007046	putative active site [active]
395965007047	oxyanion strand; other site
395965007048	catalytic triad [active]
395965007049	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
395965007050	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
395965007051	putative active site pocket [active]
395965007052	4-fold oligomerization interface [polypeptide binding]; other site
395965007053	metal binding residues [ion binding]; metal-binding site
395965007054	3-fold/trimer interface [polypeptide binding]; other site
395965007055	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
395965007056	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395965007057	FeS/SAM binding site; other site
395965007058	HemN C-terminal domain; Region: HemN_C; pfam06969
395965007059	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
395965007060	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395965007061	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395965007062	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395965007063	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
395965007064	SnoaL-like domain; Region: SnoaL_3; pfam13474
395965007065	ATP-dependent protease subunit HslV; Provisional; Region: PRK05456
395965007066	active site
395965007067	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
395965007068	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965007069	Walker A motif; other site
395965007070	ATP binding site [chemical binding]; other site
395965007071	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965007072	Walker B motif; other site
395965007073	arginine finger; other site
395965007074	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
395965007075	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
395965007076	CGNR zinc finger; Region: zf-CGNR; pfam11706
395965007077	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395965007078	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395965007079	Pirin-related protein [General function prediction only]; Region: COG1741
395965007080	Pirin; Region: Pirin; pfam02678
395965007081	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
395965007082	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
395965007083	MgtC family; Region: MgtC; pfam02308
395965007084	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
395965007085	Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576
395965007086	Uncharacterized conserved protein [Function unknown]; Region: COG2128
395965007087	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
395965007088	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
395965007089	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
395965007090	active site
395965007091	HIGH motif; other site
395965007092	dimer interface [polypeptide binding]; other site
395965007093	KMSKS motif; other site
395965007094	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
395965007095	fructuronate transporter; Provisional; Region: PRK10034; cl15264
395965007096	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
395965007097	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395965007098	dimerization interface [polypeptide binding]; other site
395965007099	putative DNA binding site [nucleotide binding]; other site
395965007100	putative Zn2+ binding site [ion binding]; other site
395965007101	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
395965007102	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
395965007103	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
395965007104	EamA-like transporter family; Region: EamA; pfam00892
395965007105	TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920
395965007106	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
395965007107	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
395965007108	active site
395965007109	Zn binding site [ion binding]; other site
395965007110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
395965007111	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
395965007112	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965007113	active site
395965007114	phosphorylation site [posttranslational modification]
395965007115	intermolecular recognition site; other site
395965007116	dimerization interface [polypeptide binding]; other site
395965007117	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965007118	Walker A motif; other site
395965007119	ATP binding site [chemical binding]; other site
395965007120	Walker B motif; other site
395965007121	arginine finger; other site
395965007122	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395965007123	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
395965007124	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395965007125	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395965007126	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395965007127	short chain dehydrogenase; Validated; Region: PRK06182
395965007128	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
395965007129	NADP binding site [chemical binding]; other site
395965007130	active site
395965007131	steroid binding site; other site
395965007132	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
395965007133	primosome assembly protein PriA; Validated; Region: PRK05580
395965007134	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395965007135	ATP binding site [chemical binding]; other site
395965007136	putative Mg++ binding site [ion binding]; other site
395965007137	helicase superfamily c-terminal domain; Region: HELICc; smart00490
395965007138	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
395965007139	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
395965007140	catalytic residues [active]
395965007141	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
395965007142	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
395965007143	trmE is a tRNA modification GTPase; Region: trmE; cd04164
395965007144	G1 box; other site
395965007145	GTP/Mg2+ binding site [chemical binding]; other site
395965007146	Switch I region; other site
395965007147	G2 box; other site
395965007148	Switch II region; other site
395965007149	G3 box; other site
395965007150	G4 box; other site
395965007151	G5 box; other site
395965007152	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
395965007153	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
395965007154	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
395965007155	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
395965007156	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
395965007157	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
395965007158	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
395965007159	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395965007160	P-loop; other site
395965007161	Magnesium ion binding site [ion binding]; other site
395965007162	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
395965007163	Magnesium ion binding site [ion binding]; other site
395965007164	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
395965007165	ParB-like nuclease domain; Region: ParB; smart00470
395965007166	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
395965007167	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
395965007168	heme binding site [chemical binding]; other site
395965007169	ferroxidase pore; other site
395965007170	ferroxidase diiron center [ion binding]; other site
395965007171	PAS domain S-box; Region: sensory_box; TIGR00229
395965007172	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395965007173	putative active site [active]
395965007174	heme pocket [chemical binding]; other site
395965007175	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395965007176	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395965007177	metal binding site [ion binding]; metal-binding site
395965007178	active site
395965007179	I-site; other site
395965007180	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395965007181	radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261
395965007182	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395965007183	FeS/SAM binding site; other site
395965007184	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
395965007185	Protein of unknown function (DUF1428); Region: DUF1428; cl02319
395965007186	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
395965007187	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
395965007188	Protein of unknown function (DUF805); Region: DUF805; pfam05656
395965007189	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
395965007190	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
395965007191	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
395965007192	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
395965007193	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395965007194	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395965007195	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965007196	dimer interface [polypeptide binding]; other site
395965007197	conserved gate region; other site
395965007198	putative PBP binding loops; other site
395965007199	ABC-ATPase subunit interface; other site
395965007200	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395965007201	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395965007202	Walker A/P-loop; other site
395965007203	ATP binding site [chemical binding]; other site
395965007204	Q-loop/lid; other site
395965007205	ABC transporter signature motif; other site
395965007206	Walker B; other site
395965007207	D-loop; other site
395965007208	H-loop/switch region; other site
395965007209	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
395965007210	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
395965007211	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
395965007212	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
395965007213	urea carboxylase; Region: urea_carbox; TIGR02712
395965007214	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395965007215	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395965007216	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
395965007217	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
395965007218	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
395965007219	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
395965007220	carboxyltransferase (CT) interaction site; other site
395965007221	biotinylation site [posttranslational modification]; other site
395965007222	allophanate hydrolase; Provisional; Region: PRK08186
395965007223	Amidase; Region: Amidase; cl11426
395965007224	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
395965007225	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
395965007226	active site
395965007227	FMN binding site [chemical binding]; other site
395965007228	substrate binding site [chemical binding]; other site
395965007229	homotetramer interface [polypeptide binding]; other site
395965007230	catalytic residue [active]
395965007231	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
395965007232	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
395965007233	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
395965007234	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395965007235	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395965007236	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
395965007237	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
395965007238	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395965007239	Surface antigen; Region: Bac_surface_Ag; pfam01103
395965007240	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
395965007241	Family of unknown function (DUF490); Region: DUF490; pfam04357
395965007242	Family of unknown function (DUF490); Region: DUF490; pfam04357
395965007243	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395965007244	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395965007245	C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202
395965007246	putative N-terminal domain interface [polypeptide binding]; other site
395965007247	putative dimer interface [polypeptide binding]; other site
395965007248	putative substrate binding pocket (H-site) [chemical binding]; other site
395965007249	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
395965007250	active site
395965007251	Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560
395965007252	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
395965007253	putative active site [active]
395965007254	catalytic site [active]
395965007255	putative metal binding site [ion binding]; other site
395965007256	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
395965007257	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
395965007258	active site
395965007259	catalytic site [active]
395965007260	substrate binding site [chemical binding]; other site
395965007261	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
395965007262	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395965007263	ligand binding site [chemical binding]; other site
395965007264	flexible hinge region; other site
395965007265	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain.  Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589
395965007266	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
395965007267	metal binding triad; other site
395965007268	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
395965007269	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
395965007270	Na binding site [ion binding]; other site
395965007271	Protein of unknown function, DUF485; Region: DUF485; pfam04341
395965007272	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395965007273	non-specific DNA binding site [nucleotide binding]; other site
395965007274	salt bridge; other site
395965007275	sequence-specific DNA binding site [nucleotide binding]; other site
395965007276	Cupin domain; Region: Cupin_2; pfam07883
395965007277	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
395965007278	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
395965007279	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
395965007280	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
395965007281	putative active site [active]
395965007282	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
395965007283	domain_subunit interface; other site
395965007284	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
395965007285	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
395965007286	active site
395965007287	FMN binding site [chemical binding]; other site
395965007288	substrate binding site [chemical binding]; other site
395965007289	3Fe-4S cluster binding site [ion binding]; other site
395965007290	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
395965007291	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
395965007292	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
395965007293	hydroxyglutarate oxidase; Provisional; Region: PRK11728
395965007294	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
395965007295	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
395965007296	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
395965007297	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
395965007298	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
395965007299	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
395965007300	folate binding site [chemical binding]; other site
395965007301	NADP+ binding site [chemical binding]; other site
395965007302	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
395965007303	C factor cell-cell signaling protein; Provisional; Region: PRK09009
395965007304	NADP binding site [chemical binding]; other site
395965007305	homodimer interface [polypeptide binding]; other site
395965007306	active site
395965007307	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
395965007308	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
395965007309	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
395965007310	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
395965007311	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
395965007312	active site residue [active]
395965007313	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
395965007314	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
395965007315	dimer interface [polypeptide binding]; other site
395965007316	decamer (pentamer of dimers) interface [polypeptide binding]; other site
395965007317	catalytic triad [active]
395965007318	PBP superfamily domain; Region: PBP_like_2; cl17296
395965007319	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14263
395965007320	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
395965007321	Walker A/P-loop; other site
395965007322	ATP binding site [chemical binding]; other site
395965007323	Q-loop/lid; other site
395965007324	ABC transporter signature motif; other site
395965007325	Walker B; other site
395965007326	D-loop; other site
395965007327	H-loop/switch region; other site
395965007328	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
395965007329	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965007330	dimer interface [polypeptide binding]; other site
395965007331	conserved gate region; other site
395965007332	putative PBP binding loops; other site
395965007333	ABC-ATPase subunit interface; other site
395965007334	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
395965007335	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965007336	dimer interface [polypeptide binding]; other site
395965007337	conserved gate region; other site
395965007338	putative PBP binding loops; other site
395965007339	ABC-ATPase subunit interface; other site
395965007340	PBP superfamily domain; Region: PBP_like_2; cl17296
395965007341	polyphosphate kinase; Provisional; Region: PRK05443
395965007342	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
395965007343	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
395965007344	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
395965007345	putative domain interface [polypeptide binding]; other site
395965007346	putative active site [active]
395965007347	catalytic site [active]
395965007348	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
395965007349	putative domain interface [polypeptide binding]; other site
395965007350	putative active site [active]
395965007351	catalytic site [active]
395965007352	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
395965007353	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
395965007354	dimer interface [polypeptide binding]; other site
395965007355	active site
395965007356	heme binding site [chemical binding]; other site
395965007357	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
395965007358	flavodoxin FldA; Validated; Region: PRK09267
395965007359	Protein of unknown function (DUF2023); Region: DUF2023; pfam09633
395965007360	Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486
395965007361	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
395965007362	Protein of unknown function (DUF1326); Region: DUF1326; pfam07040
395965007363	Helix-turn-helix domain; Region: HTH_18; pfam12833
395965007364	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395965007365	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
395965007366	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395965007367	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
395965007368	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395965007369	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
395965007370	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
395965007371	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
395965007372	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
395965007373	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
395965007374	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
395965007375	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
395965007376	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
395965007377	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
395965007378	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
395965007379	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
395965007380	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
395965007381	active site
395965007382	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395965007383	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395965007384	substrate binding pocket [chemical binding]; other site
395965007385	membrane-bound complex binding site; other site
395965007386	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395965007387	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965007388	dimer interface [polypeptide binding]; other site
395965007389	conserved gate region; other site
395965007390	putative PBP binding loops; other site
395965007391	ABC-ATPase subunit interface; other site
395965007392	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395965007393	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395965007394	Walker A/P-loop; other site
395965007395	ATP binding site [chemical binding]; other site
395965007396	Q-loop/lid; other site
395965007397	ABC transporter signature motif; other site
395965007398	Walker B; other site
395965007399	D-loop; other site
395965007400	H-loop/switch region; other site
395965007401	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
395965007402	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
395965007403	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395965007404	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965007405	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395965007406	putative effector binding pocket; other site
395965007407	dimerization interface [polypeptide binding]; other site
395965007408	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395965007409	NmrA-like family; Region: NmrA; pfam05368
395965007410	NAD(P) binding site [chemical binding]; other site
395965007411	active site
395965007412	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
395965007413	Cupin; Region: Cupin_1; smart00835
395965007414	Cupin; Region: Cupin_1; smart00835
395965007415	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395965007416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965007417	active site
395965007418	phosphorylation site [posttranslational modification]
395965007419	intermolecular recognition site; other site
395965007420	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
395965007421	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965007422	active site
395965007423	phosphorylation site [posttranslational modification]
395965007424	intermolecular recognition site; other site
395965007425	dimerization interface [polypeptide binding]; other site
395965007426	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395965007427	DNA binding residues [nucleotide binding]
395965007428	dimerization interface [polypeptide binding]; other site
395965007429	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395965007430	PAS domain; Region: PAS_9; pfam13426
395965007431	putative active site [active]
395965007432	heme pocket [chemical binding]; other site
395965007433	PAS domain; Region: PAS_9; pfam13426
395965007434	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965007435	dimer interface [polypeptide binding]; other site
395965007436	phosphorylation site [posttranslational modification]
395965007437	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965007438	ATP binding site [chemical binding]; other site
395965007439	Mg2+ binding site [ion binding]; other site
395965007440	G-X-G motif; other site
395965007441	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
395965007442	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
395965007443	TadE-like protein; Region: TadE; pfam07811
395965007444	Flp/Fap pilin component; Region: Flp_Fap; cl01585
395965007445	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
395965007446	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
395965007447	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
395965007448	AAA domain; Region: AAA_31; pfam13614
395965007449	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
395965007450	Type II/IV secretion system protein; Region: T2SE; pfam00437
395965007451	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
395965007452	ATP binding site [chemical binding]; other site
395965007453	Walker A motif; other site
395965007454	hexamer interface [polypeptide binding]; other site
395965007455	Walker B motif; other site
395965007456	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
395965007457	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
395965007458	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
395965007459	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
395965007460	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
395965007461	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
395965007462	BON domain; Region: BON; pfam04972
395965007463	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
395965007464	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965007465	binding surface
395965007466	Tetratricopeptide repeat; Region: TPR_16; pfam13432
395965007467	TPR motif; other site
395965007468	TPR repeat; Region: TPR_11; pfam13414
395965007469	CHASE domain; Region: CHASE; pfam03924
395965007470	PAS domain S-box; Region: sensory_box; TIGR00229
395965007471	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395965007472	putative active site [active]
395965007473	heme pocket [chemical binding]; other site
395965007474	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395965007475	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395965007476	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395965007477	PAS fold; Region: PAS_3; pfam08447
395965007478	putative active site [active]
395965007479	heme pocket [chemical binding]; other site
395965007480	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395965007481	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395965007482	metal binding site [ion binding]; metal-binding site
395965007483	active site
395965007484	I-site; other site
395965007485	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395965007486	GAF domain; Region: GAF; cl17456
395965007487	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395965007488	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395965007489	metal binding site [ion binding]; metal-binding site
395965007490	active site
395965007491	I-site; other site
395965007492	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
395965007493	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965007494	multidrug resistance protein MdtN; Provisional; Region: PRK10476
395965007495	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965007496	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
395965007497	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
395965007498	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
395965007499	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965007500	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965007501	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
395965007502	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965007503	The C-terminal substrate binding domain of LysR-type transcriptional regulator PnbR, which is involved in regulating the pnb genes encoding enzymes for 4-nitrobenzoate catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_PnbR; cd08469
395965007504	putative substrate binding pocket [chemical binding]; other site
395965007505	putative dimerization interface [polypeptide binding]; other site
395965007506	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
395965007507	phosphate acetyltransferase; Provisional; Region: PRK11890
395965007508	propionate/acetate kinase; Provisional; Region: PRK12379
395965007509	Acetokinase family; Region: Acetate_kinase; cl17229
395965007510	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
395965007511	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
395965007512	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
395965007513	NAD binding site [chemical binding]; other site
395965007514	homotetramer interface [polypeptide binding]; other site
395965007515	homodimer interface [polypeptide binding]; other site
395965007516	substrate binding site [chemical binding]; other site
395965007517	active site
395965007518	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
395965007519	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
395965007520	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
395965007521	NAD binding site [chemical binding]; other site
395965007522	substrate binding site [chemical binding]; other site
395965007523	homodimer interface [polypeptide binding]; other site
395965007524	active site
395965007525	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
395965007526	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
395965007527	NADP binding site [chemical binding]; other site
395965007528	active site
395965007529	putative substrate binding site [chemical binding]; other site
395965007530	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
395965007531	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
395965007532	substrate binding site; other site
395965007533	tetramer interface; other site
395965007534	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
395965007535	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
395965007536	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
395965007537	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
395965007538	active site
395965007539	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395965007540	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395965007541	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
395965007542	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965007543	S-adenosylmethionine binding site [chemical binding]; other site
395965007544	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395965007545	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395965007546	NAD(P) binding site [chemical binding]; other site
395965007547	active site
395965007548	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395965007549	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395965007550	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395965007551	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395965007552	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
395965007553	Probable Catalytic site; other site
395965007554	metal-binding site
395965007555	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524
395965007556	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
395965007557	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
395965007558	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
395965007559	active site
395965007560	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
395965007561	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
395965007562	Methyltransferase domain; Region: Methyltransf_12; pfam08242
395965007563	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395965007564	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
395965007565	Enoylreductase; Region: PKS_ER; smart00829
395965007566	NAD(P) binding site [chemical binding]; other site
395965007567	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
395965007568	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
395965007569	putative NADP binding site [chemical binding]; other site
395965007570	active site
395965007571	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
395965007572	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
395965007573	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395965007574	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
395965007575	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395965007576	active site
395965007577	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
395965007578	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
395965007579	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
395965007580	substrate-cofactor binding pocket; other site
395965007581	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965007582	catalytic residue [active]
395965007583	Methyltransferase domain; Region: Methyltransf_31; pfam13847
395965007584	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965007585	S-adenosylmethionine binding site [chemical binding]; other site
395965007586	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
395965007587	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
395965007588	Walker A/P-loop; other site
395965007589	ATP binding site [chemical binding]; other site
395965007590	Q-loop/lid; other site
395965007591	ABC transporter signature motif; other site
395965007592	Walker B; other site
395965007593	D-loop; other site
395965007594	H-loop/switch region; other site
395965007595	Chain length determinant protein; Region: Wzz; cl15801
395965007596	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524
395965007597	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
395965007598	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
395965007599	sugar binding site [chemical binding]; other site
395965007600	Methyltransferase domain; Region: Methyltransf_22; pfam13383
395965007601	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
395965007602	sugar binding site [chemical binding]; other site
395965007603	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
395965007604	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395965007605	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
395965007606	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395965007607	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
395965007608	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
395965007609	ABC-2 type transporter; Region: ABC2_membrane; cl17235
395965007610	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
395965007611	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
395965007612	dimerization interface [polypeptide binding]; other site
395965007613	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
395965007614	ATP binding site [chemical binding]; other site
395965007615	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
395965007616	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
395965007617	HupF/HypC family; Region: HupF_HypC; pfam01455
395965007618	Acylphosphatase; Region: Acylphosphatase; pfam00708
395965007619	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
395965007620	HypF finger; Region: zf-HYPF; pfam07503
395965007621	HypF finger; Region: zf-HYPF; pfam07503
395965007622	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
395965007623	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
395965007624	G1 box; other site
395965007625	GTP/Mg2+ binding site [chemical binding]; other site
395965007626	G2 box; other site
395965007627	Switch I region; other site
395965007628	G3 box; other site
395965007629	Switch II region; other site
395965007630	G4 box; other site
395965007631	G5 box; other site
395965007632	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
395965007633	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
395965007634	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395965007635	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965007636	active site
395965007637	phosphorylation site [posttranslational modification]
395965007638	intermolecular recognition site; other site
395965007639	dimerization interface [polypeptide binding]; other site
395965007640	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
395965007641	nickel binding site [ion binding]; other site
395965007642	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
395965007643	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
395965007644	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
395965007645	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395965007646	catalytic loop [active]
395965007647	iron binding site [ion binding]; other site
395965007648	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
395965007649	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
395965007650	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
395965007651	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395965007652	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
395965007653	SLBB domain; Region: SLBB; pfam10531
395965007654	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
395965007655	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
395965007656	active site clefts [active]
395965007657	zinc binding site [ion binding]; other site
395965007658	dimer interface [polypeptide binding]; other site
395965007659	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
395965007660	nucleophile elbow; other site
395965007661	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
395965007662	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
395965007663	Sulfate transporter family; Region: Sulfate_transp; pfam00916
395965007664	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
395965007665	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
395965007666	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
395965007667	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
395965007668	active site
395965007669	metal binding site [ion binding]; metal-binding site
395965007670	interdomain interaction site; other site
395965007671	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395965007672	AAA domain; Region: AAA_25; pfam13481
395965007673	Walker A motif; other site
395965007674	ATP binding site [chemical binding]; other site
395965007675	Walker B motif; other site
395965007676	recA bacterial DNA recombination protein; Region: RecA; cl17211
395965007677	circadian clock protein KaiC; Reviewed; Region: PRK09302
395965007678	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395965007679	Walker A motif; other site
395965007680	ATP binding site [chemical binding]; other site
395965007681	Walker B motif; other site
395965007682	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395965007683	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395965007684	Walker A motif; other site
395965007685	Walker A motif; other site
395965007686	ATP binding site [chemical binding]; other site
395965007687	Walker B motif; other site
395965007688	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395965007689	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965007690	dimer interface [polypeptide binding]; other site
395965007691	phosphorylation site [posttranslational modification]
395965007692	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965007693	ATP binding site [chemical binding]; other site
395965007694	G-X-G motif; other site
395965007695	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395965007696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965007697	active site
395965007698	phosphorylation site [posttranslational modification]
395965007699	intermolecular recognition site; other site
395965007700	dimerization interface [polypeptide binding]; other site
395965007701	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
395965007702	Ferritin-like domain; Region: Ferritin; pfam00210
395965007703	dimanganese center [ion binding]; other site
395965007704	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395965007705	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395965007706	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
395965007707	catalytic site [active]
395965007708	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
395965007709	ParB-like nuclease domain; Region: ParBc; pfam02195
395965007710	Response regulator receiver domain; Region: Response_reg; pfam00072
395965007711	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965007712	active site
395965007713	phosphorylation site [posttranslational modification]
395965007714	intermolecular recognition site; other site
395965007715	dimerization interface [polypeptide binding]; other site
395965007716	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
395965007717	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
395965007718	glutathione synthetase; Provisional; Region: PRK05246
395965007719	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
395965007720	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
395965007721	PII uridylyl-transferase; Provisional; Region: PRK05092
395965007722	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
395965007723	metal binding triad; other site
395965007724	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
395965007725	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
395965007726	Zn2+ binding site [ion binding]; other site
395965007727	Mg2+ binding site [ion binding]; other site
395965007728	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
395965007729	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
395965007730	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
395965007731	dimer interface [polypeptide binding]; other site
395965007732	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
395965007733	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
395965007734	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
395965007735	Predicted transcriptional regulators [Transcription]; Region: COG1733
395965007736	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
395965007737	Protein of unknown function (DUF330); Region: DUF330; cl01135
395965007738	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
395965007739	mce related protein; Region: MCE; pfam02470
395965007740	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
395965007741	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
395965007742	Walker A/P-loop; other site
395965007743	ATP binding site [chemical binding]; other site
395965007744	Q-loop/lid; other site
395965007745	ABC transporter signature motif; other site
395965007746	Walker B; other site
395965007747	D-loop; other site
395965007748	H-loop/switch region; other site
395965007749	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
395965007750	anti sigma factor interaction site; other site
395965007751	regulatory phosphorylation site [posttranslational modification]; other site
395965007752	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
395965007753	Permease; Region: Permease; pfam02405
395965007754	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
395965007755	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
395965007756	active site
395965007757	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
395965007758	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
395965007759	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
395965007760	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
395965007761	active site
395965007762	substrate binding site [chemical binding]; other site
395965007763	metal binding site [ion binding]; metal-binding site
395965007764	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
395965007765	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
395965007766	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395965007767	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395965007768	Protein of unknown function (DUF992); Region: DUF992; pfam06186
395965007769	Predicted membrane protein [Function unknown]; Region: COG2246
395965007770	GtrA-like protein; Region: GtrA; pfam04138
395965007771	pyruvate dehydrogenase; Provisional; Region: PRK09124
395965007772	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
395965007773	PYR/PP interface [polypeptide binding]; other site
395965007774	dimer interface [polypeptide binding]; other site
395965007775	tetramer interface [polypeptide binding]; other site
395965007776	TPP binding site [chemical binding]; other site
395965007777	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
395965007778	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
395965007779	TPP-binding site [chemical binding]; other site
395965007780	TspO/MBR family; Region: TspO_MBR; pfam03073
395965007781	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
395965007782	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395965007783	C-terminal domain interface [polypeptide binding]; other site
395965007784	GSH binding site (G-site) [chemical binding]; other site
395965007785	dimer interface [polypeptide binding]; other site
395965007786	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
395965007787	N-terminal domain interface [polypeptide binding]; other site
395965007788	dimer interface [polypeptide binding]; other site
395965007789	substrate binding pocket (H-site) [chemical binding]; other site
395965007790	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900
395965007791	putative hydrophobic ligand binding site [chemical binding]; other site
395965007792	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395965007793	dimerization interface [polypeptide binding]; other site
395965007794	putative DNA binding site [nucleotide binding]; other site
395965007795	putative Zn2+ binding site [ion binding]; other site
395965007796	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
395965007797	active site
395965007798	phosphorylation site [posttranslational modification]
395965007799	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395965007800	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965007801	active site
395965007802	phosphorylation site [posttranslational modification]
395965007803	intermolecular recognition site; other site
395965007804	dimerization interface [polypeptide binding]; other site
395965007805	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395965007806	DNA binding site [nucleotide binding]
395965007807	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
395965007808	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
395965007809	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
395965007810	Ligand Binding Site [chemical binding]; other site
395965007811	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
395965007812	GAF domain; Region: GAF_3; pfam13492
395965007813	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965007814	dimer interface [polypeptide binding]; other site
395965007815	phosphorylation site [posttranslational modification]
395965007816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965007817	ATP binding site [chemical binding]; other site
395965007818	Mg2+ binding site [ion binding]; other site
395965007819	G-X-G motif; other site
395965007820	potassium-transporting ATPase subunit C; Provisional; Region: PRK13999
395965007821	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
395965007822	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395965007823	Soluble P-type ATPase [General function prediction only]; Region: COG4087
395965007824	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
395965007825	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
395965007826	Fatty acid desaturase; Region: FA_desaturase; pfam00487
395965007827	putative di-iron ligands [ion binding]; other site
395965007828	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
395965007829	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
395965007830	membrane-bound complex binding site; other site
395965007831	hinge residues; other site
395965007832	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
395965007833	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965007834	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965007835	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
395965007836	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
395965007837	Walker A/P-loop; other site
395965007838	ATP binding site [chemical binding]; other site
395965007839	Q-loop/lid; other site
395965007840	ABC transporter signature motif; other site
395965007841	Walker B; other site
395965007842	D-loop; other site
395965007843	H-loop/switch region; other site
395965007844	NMT1-like family; Region: NMT1_2; pfam13379
395965007845	NMT1/THI5 like; Region: NMT1; pfam09084
395965007846	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
395965007847	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965007848	dimer interface [polypeptide binding]; other site
395965007849	conserved gate region; other site
395965007850	putative PBP binding loops; other site
395965007851	ABC-ATPase subunit interface; other site
395965007852	OsmC-like protein; Region: OsmC; pfam02566
395965007853	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
395965007854	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395965007855	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
395965007856	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
395965007857	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
395965007858	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395965007859	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
395965007860	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395965007861	Soluble P-type ATPase [General function prediction only]; Region: COG4087
395965007862	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
395965007863	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
395965007864	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
395965007865	Sulfate transporter family; Region: Sulfate_transp; pfam00916
395965007866	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
395965007867	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
395965007868	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
395965007869	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395965007870	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395965007871	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395965007872	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965007873	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
395965007874	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
395965007875	FMN binding site [chemical binding]; other site
395965007876	active site
395965007877	catalytic residues [active]
395965007878	substrate binding site [chemical binding]; other site
395965007879	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
395965007880	Protein of unknown function (DUF815); Region: DUF815; pfam05673
395965007881	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
395965007882	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
395965007883	active site
395965007884	zinc binding site [ion binding]; other site
395965007885	Preprotein translocase subunit; Region: YajC; pfam02699
395965007886	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
395965007887	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
395965007888	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
395965007889	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
395965007890	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
395965007891	Protein export membrane protein; Region: SecD_SecF; pfam02355
395965007892	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
395965007893	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
395965007894	substrate binding pocket [chemical binding]; other site
395965007895	substrate-Mg2+ binding site; other site
395965007896	aspartate-rich region 1; other site
395965007897	aspartate-rich region 2; other site
395965007898	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
395965007899	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
395965007900	active site
395965007901	HIGH motif; other site
395965007902	nucleotide binding site [chemical binding]; other site
395965007903	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
395965007904	active site
395965007905	KMSKS motif; other site
395965007906	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
395965007907	tRNA binding surface [nucleotide binding]; other site
395965007908	anticodon binding site; other site
395965007909	lipoprotein signal peptidase; Provisional; Region: PRK14796
395965007910	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
395965007911	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
395965007912	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
395965007913	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
395965007914	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
395965007915	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
395965007916	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
395965007917	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
395965007918	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
395965007919	Trp docking motif [polypeptide binding]; other site
395965007920	active site
395965007921	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
395965007922	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965007923	ATP binding site [chemical binding]; other site
395965007924	Mg2+ binding site [ion binding]; other site
395965007925	G-X-G motif; other site
395965007926	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
395965007927	ATP binding site [chemical binding]; other site
395965007928	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
395965007929	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
395965007930	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
395965007931	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
395965007932	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
395965007933	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
395965007934	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
395965007935	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
395965007936	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
395965007937	Fasciclin domain; Region: Fasciclin; pfam02469
395965007938	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
395965007939	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965007940	S-adenosylmethionine binding site [chemical binding]; other site
395965007941	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
395965007942	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
395965007943	RNA binding surface [nucleotide binding]; other site
395965007944	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
395965007945	active site
395965007946	Predicted membrane protein [Function unknown]; Region: COG3918
395965007947	mercuric reductase; Validated; Region: PRK06370
395965007948	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395965007949	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395965007950	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395965007951	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
395965007952	Protein kinase domain; Region: Pkinase; pfam00069
395965007953	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395965007954	active site
395965007955	ATP binding site [chemical binding]; other site
395965007956	substrate binding site [chemical binding]; other site
395965007957	activation loop (A-loop); other site
395965007958	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
395965007959	Protein phosphatase 2C; Region: PP2C; pfam00481
395965007960	active site
395965007961	type VI secretion-associated protein, BMA_A0400 family; Region: VI_minor_4; TIGR03373
395965007962	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
395965007963	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
395965007964	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
395965007965	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
395965007966	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
395965007967	ligand binding site [chemical binding]; other site
395965007968	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
395965007969	phosphopeptide binding site; other site
395965007970	Caspase domain; Region: Peptidase_C14; pfam00656
395965007971	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
395965007972	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
395965007973	inhibitor-cofactor binding pocket; inhibition site
395965007974	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965007975	catalytic residue [active]
395965007976	RimM N-terminal domain; Region: RimM; pfam01782
395965007977	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
395965007978	PRC-barrel domain; Region: PRC; pfam05239
395965007979	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
395965007980	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
395965007981	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
395965007982	DXD motif; other site
395965007983	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965007984	S-adenosylmethionine binding site [chemical binding]; other site
395965007985	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395965007986	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395965007987	non-specific DNA binding site [nucleotide binding]; other site
395965007988	salt bridge; other site
395965007989	sequence-specific DNA binding site [nucleotide binding]; other site
395965007990	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
395965007991	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
395965007992	putative active site [active]
395965007993	catalytic triad [active]
395965007994	putative dimer interface [polypeptide binding]; other site
395965007995	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
395965007996	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
395965007997	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
395965007998	Transporter associated domain; Region: CorC_HlyC; smart01091
395965007999	metal-binding heat shock protein; Provisional; Region: PRK00016
395965008000	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
395965008001	PhoH-like protein; Region: PhoH; pfam02562
395965008002	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
395965008003	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
395965008004	TRAM domain; Region: TRAM; pfam01938
395965008005	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
395965008006	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395965008007	Coenzyme A binding pocket [chemical binding]; other site
395965008008	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
395965008009	Glycoprotease family; Region: Peptidase_M22; pfam00814
395965008010	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
395965008011	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
395965008012	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
395965008013	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
395965008014	UbiA prenyltransferase family; Region: UbiA; pfam01040
395965008015	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
395965008016	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395965008017	Soluble P-type ATPase [General function prediction only]; Region: COG4087
395965008018	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
395965008019	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
395965008020	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
395965008021	Glucose inhibited division protein A; Region: GIDA; pfam01134
395965008022	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
395965008023	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
395965008024	Multicopper oxidase; Region: Cu-oxidase; pfam00394
395965008025	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
395965008026	trigger factor; Provisional; Region: tig; PRK01490
395965008027	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
395965008028	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
395965008029	Clp protease; Region: CLP_protease; pfam00574
395965008030	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
395965008031	oligomer interface [polypeptide binding]; other site
395965008032	active site residues [active]
395965008033	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
395965008034	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
395965008035	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965008036	Walker A motif; other site
395965008037	ATP binding site [chemical binding]; other site
395965008038	Walker B motif; other site
395965008039	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
395965008040	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
395965008041	Found in ATP-dependent protease La (LON); Region: LON; smart00464
395965008042	Found in ATP-dependent protease La (LON); Region: LON; smart00464
395965008043	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965008044	Walker A motif; other site
395965008045	ATP binding site [chemical binding]; other site
395965008046	Walker B motif; other site
395965008047	arginine finger; other site
395965008048	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
395965008049	Domain of unknown function DUF29; Region: DUF29; pfam01724
395965008050	xanthine permease; Region: pbuX; TIGR03173
395965008051	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
395965008052	NADH dehydrogenase subunit B; Validated; Region: PRK06411
395965008053	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
395965008054	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
395965008055	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
395965008056	NADH dehydrogenase subunit D; Validated; Region: PRK06075
395965008057	NADH dehydrogenase subunit E; Validated; Region: PRK07539
395965008058	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
395965008059	putative dimer interface [polypeptide binding]; other site
395965008060	[2Fe-2S] cluster binding site [ion binding]; other site
395965008061	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
395965008062	SLBB domain; Region: SLBB; pfam10531
395965008063	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
395965008064	NADH dehydrogenase subunit G; Validated; Region: PRK09130
395965008065	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395965008066	catalytic loop [active]
395965008067	iron binding site [ion binding]; other site
395965008068	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
395965008069	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
395965008070	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
395965008071	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
395965008072	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
395965008073	4Fe-4S binding domain; Region: Fer4; pfam00037
395965008074	4Fe-4S binding domain; Region: Fer4; pfam00037
395965008075	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
395965008076	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
395965008077	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
395965008078	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
395965008079	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
395965008080	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395965008081	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
395965008082	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395965008083	NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00196
395965008084	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
395965008085	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
395965008086	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
395965008087	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
395965008088	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
395965008089	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
395965008090	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
395965008091	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395965008092	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
395965008093	dimer interface [polypeptide binding]; other site
395965008094	substrate binding site [chemical binding]; other site
395965008095	metal binding site [ion binding]; metal-binding site
395965008096	Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382
395965008097	Flavoprotein; Region: Flavoprotein; cl08021
395965008098	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
395965008099	DNA binding residues [nucleotide binding]
395965008100	dimerization interface [polypeptide binding]; other site
395965008101	benzoylformate decarboxylase; Reviewed; Region: PRK07092
395965008102	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
395965008103	PYR/PP interface [polypeptide binding]; other site
395965008104	dimer interface [polypeptide binding]; other site
395965008105	TPP binding site [chemical binding]; other site
395965008106	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
395965008107	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
395965008108	TPP-binding site [chemical binding]; other site
395965008109	dimer interface [polypeptide binding]; other site
395965008110	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395965008111	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
395965008112	catalytic site [active]
395965008113	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
395965008114	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
395965008115	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
395965008116	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
395965008117	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395965008118	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
395965008119	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
395965008120	Walker A/P-loop; other site
395965008121	ATP binding site [chemical binding]; other site
395965008122	Q-loop/lid; other site
395965008123	ABC transporter signature motif; other site
395965008124	Walker B; other site
395965008125	D-loop; other site
395965008126	H-loop/switch region; other site
395965008127	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
395965008128	Walker A/P-loop; other site
395965008129	ATP binding site [chemical binding]; other site
395965008130	Q-loop/lid; other site
395965008131	ABC transporter signature motif; other site
395965008132	Walker B; other site
395965008133	D-loop; other site
395965008134	H-loop/switch region; other site
395965008135	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
395965008136	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395965008137	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
395965008138	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395965008139	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965008140	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
395965008141	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
395965008142	putative [4Fe-4S] binding site [ion binding]; other site
395965008143	putative molybdopterin cofactor binding site [chemical binding]; other site
395965008144	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
395965008145	putative molybdopterin cofactor binding site; other site
395965008146	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
395965008147	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
395965008148	nucleotide binding site [chemical binding]; other site
395965008149	NEF interaction site [polypeptide binding]; other site
395965008150	SBD interface [polypeptide binding]; other site
395965008151	chaperone protein DnaJ; Provisional; Region: PRK10767
395965008152	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395965008153	HSP70 interaction site [polypeptide binding]; other site
395965008154	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
395965008155	substrate binding site [polypeptide binding]; other site
395965008156	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
395965008157	Zn binding sites [ion binding]; other site
395965008158	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
395965008159	dimer interface [polypeptide binding]; other site
395965008160	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965008161	S-adenosylmethionine binding site [chemical binding]; other site
395965008162	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
395965008163	active site
395965008164	dimer interface [polypeptide binding]; other site
395965008165	dihydrodipicolinate reductase; Provisional; Region: PRK00048
395965008166	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
395965008167	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
395965008168	aspartate aminotransferase; Provisional; Region: PRK05764
395965008169	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395965008170	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965008171	homodimer interface [polypeptide binding]; other site
395965008172	catalytic residue [active]
395965008173	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
395965008174	Predicted membrane protein [Function unknown]; Region: COG1238
395965008175	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
395965008176	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
395965008177	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395965008178	FeS/SAM binding site; other site
395965008179	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
395965008180	Methyltransferase domain; Region: Methyltransf_23; pfam13489
395965008181	Methyltransferase domain; Region: Methyltransf_11; pfam08241
395965008182	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
395965008183	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
395965008184	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
395965008185	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395965008186	active site
395965008187	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
395965008188	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
395965008189	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965008190	catalytic residue [active]
395965008191	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965008192	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965008193	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
395965008194	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
395965008195	NAD binding site [chemical binding]; other site
395965008196	homotetramer interface [polypeptide binding]; other site
395965008197	homodimer interface [polypeptide binding]; other site
395965008198	substrate binding site [chemical binding]; other site
395965008199	active site
395965008200	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
395965008201	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
395965008202	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
395965008203	dimer interaction site [polypeptide binding]; other site
395965008204	substrate-binding tunnel; other site
395965008205	active site
395965008206	catalytic site [active]
395965008207	substrate binding site [chemical binding]; other site
395965008208	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
395965008209	propionate/acetate kinase; Provisional; Region: PRK12379
395965008210	Acetokinase family; Region: Acetate_kinase; cl17229
395965008211	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
395965008212	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
395965008213	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
395965008214	Sulfate transporter family; Region: Sulfate_transp; pfam00916
395965008215	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
395965008216	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
395965008217	active site
395965008218	homotetramer interface [polypeptide binding]; other site
395965008219	homodimer interface [polypeptide binding]; other site
395965008220	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
395965008221	signal recognition particle protein; Provisional; Region: PRK10867
395965008222	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
395965008223	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
395965008224	P loop; other site
395965008225	GTP binding site [chemical binding]; other site
395965008226	Signal peptide binding domain; Region: SRP_SPB; pfam02978
395965008227	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
395965008228	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965008229	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395965008230	putative substrate translocation pore; other site
395965008231	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
395965008232	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395965008233	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395965008234	4Fe-4S binding domain; Region: Fer4; pfam00037
395965008235	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
395965008236	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
395965008237	dimer interface [polypeptide binding]; other site
395965008238	PYR/PP interface [polypeptide binding]; other site
395965008239	TPP binding site [chemical binding]; other site
395965008240	substrate binding site [chemical binding]; other site
395965008241	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
395965008242	Domain of unknown function; Region: EKR; pfam10371
395965008243	4Fe-4S binding domain; Region: Fer4_6; pfam12837
395965008244	4Fe-4S binding domain; Region: Fer4; pfam00037
395965008245	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
395965008246	TPP-binding site [chemical binding]; other site
395965008247	dimer interface [polypeptide binding]; other site
395965008248	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
395965008249	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
395965008250	phosphate binding site [ion binding]; other site
395965008251	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
395965008252	30S ribosomal protein S13; Region: bact_S13; TIGR03631
395965008253	30S ribosomal protein S11; Validated; Region: PRK05309
395965008254	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
395965008255	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
395965008256	alphaNTD - beta interaction site [polypeptide binding]; other site
395965008257	alphaNTD homodimer interface [polypeptide binding]; other site
395965008258	alphaNTD - beta' interaction site [polypeptide binding]; other site
395965008259	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
395965008260	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
395965008261	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
395965008262	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
395965008263	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395965008264	protein binding site [polypeptide binding]; other site
395965008265	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
395965008266	protein binding site [polypeptide binding]; other site
395965008267	recombination factor protein RarA; Reviewed; Region: PRK13342
395965008268	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965008269	Walker A motif; other site
395965008270	ATP binding site [chemical binding]; other site
395965008271	Walker B motif; other site
395965008272	arginine finger; other site
395965008273	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
395965008274	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
395965008275	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
395965008276	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
395965008277	putative acyltransferase; Provisional; Region: PRK05790
395965008278	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
395965008279	dimer interface [polypeptide binding]; other site
395965008280	active site
395965008281	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
395965008282	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
395965008283	NAD(P) binding site [chemical binding]; other site
395965008284	homotetramer interface [polypeptide binding]; other site
395965008285	homodimer interface [polypeptide binding]; other site
395965008286	active site
395965008287	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
395965008288	ThiC-associated domain; Region: ThiC-associated; pfam13667
395965008289	ThiC family; Region: ThiC; pfam01964
395965008290	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
395965008291	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
395965008292	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
395965008293	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
395965008294	nucleoside/Zn binding site; other site
395965008295	dimer interface [polypeptide binding]; other site
395965008296	catalytic motif [active]
395965008297	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
395965008298	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
395965008299	putative NAD(P) binding site [chemical binding]; other site
395965008300	LrgB-like family; Region: LrgB; pfam04172
395965008301	LrgA family; Region: LrgA; pfam03788
395965008302	Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582
395965008303	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
395965008304	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
395965008305	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
395965008306	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
395965008307	PYR/PP interface [polypeptide binding]; other site
395965008308	dimer interface [polypeptide binding]; other site
395965008309	TPP binding site [chemical binding]; other site
395965008310	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
395965008311	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
395965008312	TPP-binding site [chemical binding]; other site
395965008313	dimer interface [polypeptide binding]; other site
395965008314	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
395965008315	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
395965008316	putative valine binding site [chemical binding]; other site
395965008317	dimer interface [polypeptide binding]; other site
395965008318	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
395965008319	ketol-acid reductoisomerase; Provisional; Region: PRK05479
395965008320	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
395965008321	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
395965008322	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
395965008323	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
395965008324	G1 box; other site
395965008325	putative GEF interaction site [polypeptide binding]; other site
395965008326	GTP/Mg2+ binding site [chemical binding]; other site
395965008327	Switch I region; other site
395965008328	G2 box; other site
395965008329	G3 box; other site
395965008330	Switch II region; other site
395965008331	G4 box; other site
395965008332	G5 box; other site
395965008333	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
395965008334	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
395965008335	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
395965008336	dimer interface [polypeptide binding]; other site
395965008337	substrate binding site [chemical binding]; other site
395965008338	ATP binding site [chemical binding]; other site
395965008339	Protein of unknown function (DUF2937); Region: DUF2937; pfam11157
395965008340	FOG: WD40 repeat [General function prediction only]; Region: COG2319
395965008341	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
395965008342	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
395965008343	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
395965008344	P-loop, Walker A motif; other site
395965008345	Base recognition motif; other site
395965008346	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
395965008347	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395965008348	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395965008349	substrate binding pocket [chemical binding]; other site
395965008350	membrane-bound complex binding site; other site
395965008351	hinge residues; other site
395965008352	siroheme synthase; Provisional; Region: cysG; PRK10637
395965008353	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
395965008354	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
395965008355	active site
395965008356	SAM binding site [chemical binding]; other site
395965008357	homodimer interface [polypeptide binding]; other site
395965008358	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
395965008359	GntP family permease; Region: GntP_permease; pfam02447
395965008360	fructuronate transporter; Provisional; Region: PRK10034; cl15264
395965008361	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
395965008362	AAA domain; Region: AAA_33; pfam13671
395965008363	ATP-binding site [chemical binding]; other site
395965008364	Gluconate-6-phosphate binding site [chemical binding]; other site
395965008365	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
395965008366	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
395965008367	G1 box; other site
395965008368	putative GEF interaction site [polypeptide binding]; other site
395965008369	GTP/Mg2+ binding site [chemical binding]; other site
395965008370	Switch I region; other site
395965008371	G2 box; other site
395965008372	G3 box; other site
395965008373	Switch II region; other site
395965008374	G4 box; other site
395965008375	G5 box; other site
395965008376	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
395965008377	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
395965008378	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
395965008379	ATP binding site [chemical binding]; other site
395965008380	active site
395965008381	substrate binding site [chemical binding]; other site
395965008382	Predicted transcriptional regulators [Transcription]; Region: COG1695
395965008383	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
395965008384	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395965008385	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395965008386	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
395965008387	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
395965008388	DNA binding site [nucleotide binding]
395965008389	catalytic residue [active]
395965008390	H2TH interface [polypeptide binding]; other site
395965008391	putative catalytic residues [active]
395965008392	turnover-facilitating residue; other site
395965008393	intercalation triad [nucleotide binding]; other site
395965008394	8OG recognition residue [nucleotide binding]; other site
395965008395	putative reading head residues; other site
395965008396	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
395965008397	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
395965008398	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
395965008399	active site
395965008400	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
395965008401	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
395965008402	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
395965008403	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
395965008404	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
395965008405	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
395965008406	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
395965008407	Predicted transcriptional regulator [Transcription]; Region: COG2932
395965008408	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
395965008409	Catalytic site [active]
395965008410	Phage terminase large subunit; Region: Terminase_3; cl12054
395965008411	Uncharacterized conserved protein [Function unknown]; Region: COG5323
395965008412	Phage portal protein; Region: Phage_portal; pfam04860
395965008413	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
395965008414	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
395965008415	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
395965008416	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
395965008417	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
395965008418	NlpC/P60 family; Region: NLPC_P60; cl17555
395965008419	Putative phage tail protein; Region: Phage-tail_3; pfam13550
395965008420	major tropism determinant; Region: mtd; PHA00653
395965008421	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
395965008422	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
395965008423	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
395965008424	Spc19; Region: DASH_Spc19; pfam08287
395965008425	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
395965008426	MOSC domain; Region: MOSC; pfam03473
395965008427	3-alpha domain; Region: 3-alpha; pfam03475
395965008428	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
395965008429	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
395965008430	FAD binding pocket [chemical binding]; other site
395965008431	FAD binding motif [chemical binding]; other site
395965008432	phosphate binding motif [ion binding]; other site
395965008433	beta-alpha-beta structure motif; other site
395965008434	NAD binding pocket [chemical binding]; other site
395965008435	Heme binding  pocket [chemical binding]; other site
395965008436	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395965008437	catalytic loop [active]
395965008438	iron binding site [ion binding]; other site
395965008439	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
395965008440	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
395965008441	NAD binding site [chemical binding]; other site
395965008442	dimerization interface [polypeptide binding]; other site
395965008443	product binding site; other site
395965008444	substrate binding site [chemical binding]; other site
395965008445	zinc binding site [ion binding]; other site
395965008446	catalytic residues [active]
395965008447	hypothetical protein; Provisional; Region: PRK02853
395965008448	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
395965008449	Low molecular weight phosphatase family; Region: LMWPc; cd00115
395965008450	active site
395965008451	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
395965008452	DHH family; Region: DHH; pfam01368
395965008453	DHHA1 domain; Region: DHHA1; pfam02272
395965008454	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
395965008455	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395965008456	non-specific DNA binding site [nucleotide binding]; other site
395965008457	salt bridge; other site
395965008458	sequence-specific DNA binding site [nucleotide binding]; other site
395965008459	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
395965008460	catalytic motif [active]
395965008461	Catalytic residue [active]
395965008462	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395965008463	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395965008464	catalytic residue [active]
395965008465	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
395965008466	Terminase-like family; Region: Terminase_6; pfam03237
395965008467	Virulence-associated protein E; Region: VirE; pfam05272
395965008468	Helix-turn-helix domain; Region: HTH_17; cl17695
395965008469	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
395965008470	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395965008471	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
395965008472	active site
395965008473	catalytic residues [active]
395965008474	DNA binding site [nucleotide binding]
395965008475	Int/Topo IB signature motif; other site
395965008476	Domain of unknown function (DUF955); Region: DUF955; cl01076
395965008477	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
395965008478	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
395965008479	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
395965008480	active site
395965008481	DNA binding site [nucleotide binding]
395965008482	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
395965008483	DNA binding site [nucleotide binding]
395965008484	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
395965008485	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
395965008486	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
395965008487	multiple promoter invertase; Provisional; Region: mpi; PRK13413
395965008488	catalytic residues [active]
395965008489	catalytic nucleophile [active]
395965008490	Presynaptic Site I dimer interface [polypeptide binding]; other site
395965008491	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
395965008492	Synaptic Flat tetramer interface [polypeptide binding]; other site
395965008493	Synaptic Site I dimer interface [polypeptide binding]; other site
395965008494	DNA binding site [nucleotide binding]
395965008495	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
395965008496	DNA-binding interface [nucleotide binding]; DNA binding site
395965008497	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
395965008498	nucleotide binding site [chemical binding]; other site
395965008499	polymerase nucleotide-binding site; other site
395965008500	primase nucleotide-binding site [nucleotide binding]; other site
395965008501	DNA-binding residues [nucleotide binding]; DNA binding site
395965008502	AAA domain; Region: AAA_25; pfam13481
395965008503	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
395965008504	Walker A motif; other site
395965008505	ATP binding site [chemical binding]; other site
395965008506	Walker B motif; other site
395965008507	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
395965008508	active site
395965008509	catalytic residues [active]
395965008510	DNA binding site [nucleotide binding]
395965008511	Int/Topo IB signature motif; other site
395965008512	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
395965008513	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
395965008514	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
395965008515	Uncharacterized conserved protein [Function unknown]; Region: COG1262
395965008516	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
395965008517	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
395965008518	Sulfatase; Region: Sulfatase; pfam00884
395965008519	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
395965008520	endonuclease III; Region: ENDO3c; smart00478
395965008521	minor groove reading motif; other site
395965008522	helix-hairpin-helix signature motif; other site
395965008523	substrate binding pocket [chemical binding]; other site
395965008524	active site
395965008525	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
395965008526	binding surface
395965008527	TPR motif; other site
395965008528	Domain of unknown function (DUF336); Region: DUF336; pfam03928
395965008529	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
395965008530	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
395965008531	catalytic triad [active]
395965008532	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
395965008533	active site residue [active]
395965008534	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
395965008535	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
395965008536	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
395965008537	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
395965008538	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
395965008539	Cytochrome C' Region: Cytochrom_C_2; pfam01322
395965008540	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
395965008541	TolR protein; Region: tolR; TIGR02801
395965008542	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
395965008543	Gram-negative bacterial tonB protein; Region: TonB; cl10048
395965008544	Predicted transcriptional regulator [Transcription]; Region: COG1959
395965008545	Transcriptional regulator; Region: Rrf2; pfam02082
395965008546	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395965008547	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395965008548	non-specific DNA binding site [nucleotide binding]; other site
395965008549	salt bridge; other site
395965008550	sequence-specific DNA binding site [nucleotide binding]; other site
395965008551	Cupin domain; Region: Cupin_2; cl17218
395965008552	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
395965008553	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395965008554	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
395965008555	intracellular septation protein A; Reviewed; Region: PRK00259
395965008556	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395965008557	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965008558	active site
395965008559	phosphorylation site [posttranslational modification]
395965008560	intermolecular recognition site; other site
395965008561	dimerization interface [polypeptide binding]; other site
395965008562	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395965008563	DNA binding residues [nucleotide binding]
395965008564	dimerization interface [polypeptide binding]; other site
395965008565	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
395965008566	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
395965008567	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
395965008568	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
395965008569	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
395965008570	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
395965008571	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
395965008572	ligand binding site [chemical binding]; other site
395965008573	Cytochrome c; Region: Cytochrom_C; cl11414
395965008574	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
395965008575	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
395965008576	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
395965008577	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
395965008578	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
395965008579	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
395965008580	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
395965008581	Trp docking motif [polypeptide binding]; other site
395965008582	dimer interface [polypeptide binding]; other site
395965008583	active site
395965008584	small subunit binding site [polypeptide binding]; other site
395965008585	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
395965008586	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395965008587	HAMP domain; Region: HAMP; pfam00672
395965008588	Histidine kinase; Region: HisKA_3; pfam07730
395965008589	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965008590	ATP binding site [chemical binding]; other site
395965008591	Mg2+ binding site [ion binding]; other site
395965008592	G-X-G motif; other site
395965008593	Transcriptional regulators [Transcription]; Region: MarR; COG1846
395965008594	MarR family; Region: MarR_2; pfam12802
395965008595	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
395965008596	tetramer interface [polypeptide binding]; other site
395965008597	active site
395965008598	Mg2+/Mn2+ binding site [ion binding]; other site
395965008599	isocitrate lyase; Region: PLN02892
395965008600	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395965008601	sequence-specific DNA binding site [nucleotide binding]; other site
395965008602	salt bridge; other site
395965008603	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
395965008604	Domain of unknown function (DUF955); Region: DUF955; pfam06114
395965008605	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
395965008606	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
395965008607	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
395965008608	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
395965008609	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
395965008610	active site
395965008611	DNA polymerase IV; Validated; Region: PRK02406
395965008612	DNA binding site [nucleotide binding]
395965008613	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395965008614	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395965008615	ligand binding site [chemical binding]; other site
395965008616	flexible hinge region; other site
395965008617	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
395965008618	CHASE2 domain; Region: CHASE2; pfam05226
395965008619	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
395965008620	cyclase homology domain; Region: CHD; cd07302
395965008621	nucleotidyl binding site; other site
395965008622	metal binding site [ion binding]; metal-binding site
395965008623	dimer interface [polypeptide binding]; other site
395965008624	FecR protein; Region: FecR; pfam04773
395965008625	Cytochrome c; Region: Cytochrom_C; pfam00034
395965008626	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395965008627	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395965008628	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
395965008629	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395965008630	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
395965008631	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156
395965008632	putative active site [active]
395965008633	catalytic site [active]
395965008634	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162
395965008635	putative active site [active]
395965008636	catalytic site [active]
395965008637	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
395965008638	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
395965008639	NAD binding site [chemical binding]; other site
395965008640	ligand binding site [chemical binding]; other site
395965008641	catalytic site [active]
395965008642	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
395965008643	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965008644	Walker A motif; other site
395965008645	ATP binding site [chemical binding]; other site
395965008646	Walker B motif; other site
395965008647	arginine finger; other site
395965008648	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
395965008649	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
395965008650	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
395965008651	putative dimer interface [polypeptide binding]; other site
395965008652	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
395965008653	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
395965008654	Bacterial sugar transferase; Region: Bac_transf; pfam02397
395965008655	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
395965008656	putative heme binding pocket [chemical binding]; other site
395965008657	Domain of unknown function (DUF427); Region: DUF427; pfam04248
395965008658	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
395965008659	catalytic residues [active]
395965008660	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
395965008661	active site residue [active]
395965008662	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
395965008663	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
395965008664	Acyl transferase domain; Region: Acyl_transf_1; cl08282
395965008665	triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132
395965008666	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
395965008667	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913
395965008668	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
395965008669	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
395965008670	malonate decarboxylase subunit delta; Provisional; Region: PRK02103
395965008671	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
395965008672	Coenzyme A transferase; Region: CoA_trans; cl17247
395965008673	Malonate transporter MadL subunit; Region: MadL; cl04273
395965008674	Malonate/sodium symporter MadM subunit; Region: MadM; cl04274
395965008675	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395965008676	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395965008677	DNA-binding site [nucleotide binding]; DNA binding site
395965008678	FCD domain; Region: FCD; pfam07729
395965008679	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
395965008680	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
395965008681	putative active site [active]
395965008682	metal binding site [ion binding]; metal-binding site
395965008683	YceI-like domain; Region: YceI; smart00867
395965008684	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
395965008685	Uncharacterized conserved protein [Function unknown]; Region: COG2353
395965008686	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395965008687	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965008688	LysR substrate binding domain; Region: LysR_substrate; pfam03466
395965008689	dimerization interface [polypeptide binding]; other site
395965008690	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
395965008691	active site
395965008692	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
395965008693	Catalytic domain of Protein Kinases; Region: PKc; cd00180
395965008694	active site
395965008695	ATP binding site [chemical binding]; other site
395965008696	substrate binding site [chemical binding]; other site
395965008697	activation loop (A-loop); other site
395965008698	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
395965008699	Ligand Binding Site [chemical binding]; other site
395965008700	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
395965008701	CHASE3 domain; Region: CHASE3; pfam05227
395965008702	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965008703	dimer interface [polypeptide binding]; other site
395965008704	phosphorylation site [posttranslational modification]
395965008705	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965008706	ATP binding site [chemical binding]; other site
395965008707	Mg2+ binding site [ion binding]; other site
395965008708	G-X-G motif; other site
395965008709	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395965008710	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965008711	active site
395965008712	phosphorylation site [posttranslational modification]
395965008713	intermolecular recognition site; other site
395965008714	dimerization interface [polypeptide binding]; other site
395965008715	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
395965008716	putative active site [active]
395965008717	putative catalytic site [active]
395965008718	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395965008719	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395965008720	active site
395965008721	catalytic tetrad [active]
395965008722	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
395965008723	active site 1 [active]
395965008724	dimer interface [polypeptide binding]; other site
395965008725	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
395965008726	hexamer interface [polypeptide binding]; other site
395965008727	active site 2 [active]
395965008728	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
395965008729	apolar tunnel; other site
395965008730	heme binding site [chemical binding]; other site
395965008731	dimerization interface [polypeptide binding]; other site
395965008732	Predicted integral membrane protein [Function unknown]; Region: COG5615
395965008733	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395965008734	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965008735	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395965008736	putative effector binding pocket; other site
395965008737	dimerization interface [polypeptide binding]; other site
395965008738	Pirin-related protein [General function prediction only]; Region: COG1741
395965008739	Pirin; Region: Pirin; pfam02678
395965008740	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
395965008741	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
395965008742	Predicted membrane protein [Function unknown]; Region: COG2259
395965008743	Protein of unknown function (DUF2853); Region: DUF2853; pfam11015
395965008744	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
395965008745	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
395965008746	iron-sulfur cluster [ion binding]; other site
395965008747	[2Fe-2S] cluster binding site [ion binding]; other site
395965008748	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
395965008749	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395965008750	CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934
395965008751	recombination protein F; Reviewed; Region: recF; PRK00064
395965008752	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395965008753	Walker A/P-loop; other site
395965008754	ATP binding site [chemical binding]; other site
395965008755	Q-loop/lid; other site
395965008756	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395965008757	ABC transporter signature motif; other site
395965008758	Walker B; other site
395965008759	D-loop; other site
395965008760	H-loop/switch region; other site
395965008761	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
395965008762	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
395965008763	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
395965008764	P loop; other site
395965008765	GTP binding site [chemical binding]; other site
395965008766	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
395965008767	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
395965008768	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
395965008769	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
395965008770	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395965008771	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
395965008772	active site
395965008773	catalytic triad [active]
395965008774	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
395965008775	nucleoside/Zn binding site; other site
395965008776	dimer interface [polypeptide binding]; other site
395965008777	catalytic motif [active]
395965008778	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
395965008779	active site
395965008780	SAM binding site [chemical binding]; other site
395965008781	homodimer interface [polypeptide binding]; other site
395965008782	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
395965008783	gating phenylalanine in ion channel; other site
395965008784	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
395965008785	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965008786	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
395965008787	putative dimerization interface [polypeptide binding]; other site
395965008788	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
395965008789	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
395965008790	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
395965008791	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
395965008792	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
395965008793	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
395965008794	Walker A/P-loop; other site
395965008795	ATP binding site [chemical binding]; other site
395965008796	Q-loop/lid; other site
395965008797	ABC transporter signature motif; other site
395965008798	Walker B; other site
395965008799	D-loop; other site
395965008800	H-loop/switch region; other site
395965008801	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
395965008802	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395965008803	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965008804	homodimer interface [polypeptide binding]; other site
395965008805	catalytic residue [active]
395965008806	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
395965008807	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
395965008808	putative NADP binding site [chemical binding]; other site
395965008809	putative substrate binding site [chemical binding]; other site
395965008810	active site
395965008811	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
395965008812	active site lid residues [active]
395965008813	substrate binding pocket [chemical binding]; other site
395965008814	catalytic residues [active]
395965008815	substrate-Mg2+ binding site; other site
395965008816	aspartate-rich region 1; other site
395965008817	aspartate-rich region 2; other site
395965008818	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
395965008819	active site lid residues [active]
395965008820	substrate binding pocket [chemical binding]; other site
395965008821	catalytic residues [active]
395965008822	substrate-Mg2+ binding site; other site
395965008823	aspartate-rich region 1; other site
395965008824	aspartate-rich region 2; other site
395965008825	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
395965008826	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
395965008827	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
395965008828	Active site cavity [active]
395965008829	catalytic acid [active]
395965008830	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
395965008831	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
395965008832	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395965008833	FeS/SAM binding site; other site
395965008834	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
395965008835	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
395965008836	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395965008837	ATP binding site [chemical binding]; other site
395965008838	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
395965008839	putative Mg++ binding site [ion binding]; other site
395965008840	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395965008841	nucleotide binding region [chemical binding]; other site
395965008842	ATP-binding site [chemical binding]; other site
395965008843	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
395965008844	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395965008845	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
395965008846	active site
395965008847	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
395965008848	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
395965008849	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
395965008850	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
395965008851	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
395965008852	ligand binding site [chemical binding]; other site
395965008853	homodimer interface [polypeptide binding]; other site
395965008854	NAD(P) binding site [chemical binding]; other site
395965008855	trimer interface B [polypeptide binding]; other site
395965008856	trimer interface A [polypeptide binding]; other site
395965008857	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
395965008858	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
395965008859	ABC1 family; Region: ABC1; cl17513
395965008860	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395965008861	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
395965008862	Coenzyme A binding pocket [chemical binding]; other site
395965008863	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
395965008864	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395965008865	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
395965008866	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
395965008867	active site
395965008868	SAM binding site [chemical binding]; other site
395965008869	homodimer interface [polypeptide binding]; other site
395965008870	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
395965008871	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
395965008872	active site
395965008873	putative homodimer interface [polypeptide binding]; other site
395965008874	SAM binding site [chemical binding]; other site
395965008875	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
395965008876	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
395965008877	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
395965008878	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
395965008879	active site
395965008880	SAM binding site [chemical binding]; other site
395965008881	homodimer interface [polypeptide binding]; other site
395965008882	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
395965008883	active site
395965008884	SAM binding site [chemical binding]; other site
395965008885	homodimer interface [polypeptide binding]; other site
395965008886	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
395965008887	Precorrin-8X methylmutase; Region: CbiC; pfam02570
395965008888	precorrin-3B synthase; Region: CobG; TIGR02435
395965008889	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395965008890	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395965008891	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
395965008892	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
395965008893	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
395965008894	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
395965008895	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
395965008896	c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874
395965008897	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
395965008898	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
395965008899	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
395965008900	homodimer interface [polypeptide binding]; other site
395965008901	Walker A motif; other site
395965008902	ATP binding site [chemical binding]; other site
395965008903	hydroxycobalamin binding site [chemical binding]; other site
395965008904	Walker B motif; other site
395965008905	cobyric acid synthase; Provisional; Region: PRK00784
395965008906	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
395965008907	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
395965008908	catalytic triad [active]
395965008909	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
395965008910	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
395965008911	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
395965008912	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965008913	homodimer interface [polypeptide binding]; other site
395965008914	catalytic residue [active]
395965008915	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
395965008916	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
395965008917	active site
395965008918	(T/H)XGH motif; other site
395965008919	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
395965008920	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
395965008921	putative catalytic cysteine [active]
395965008922	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
395965008923	putative active site pocket [active]
395965008924	dimerization interface [polypeptide binding]; other site
395965008925	putative catalytic residue [active]
395965008926	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
395965008927	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395965008928	substrate binding pocket [chemical binding]; other site
395965008929	membrane-bound complex binding site; other site
395965008930	hinge residues; other site
395965008931	gamma-glutamyl kinase; Provisional; Region: PRK05429
395965008932	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
395965008933	nucleotide binding site [chemical binding]; other site
395965008934	homotetrameric interface [polypeptide binding]; other site
395965008935	putative phosphate binding site [ion binding]; other site
395965008936	putative allosteric binding site; other site
395965008937	PUA domain; Region: PUA; pfam01472
395965008938	GTPase CgtA; Reviewed; Region: obgE; PRK12299
395965008939	GTP1/OBG; Region: GTP1_OBG; pfam01018
395965008940	Obg GTPase; Region: Obg; cd01898
395965008941	G1 box; other site
395965008942	GTP/Mg2+ binding site [chemical binding]; other site
395965008943	Switch I region; other site
395965008944	G2 box; other site
395965008945	G3 box; other site
395965008946	Switch II region; other site
395965008947	G4 box; other site
395965008948	G5 box; other site
395965008949	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
395965008950	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
395965008951	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
395965008952	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
395965008953	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
395965008954	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
395965008955	Peptidase family M23; Region: Peptidase_M23; pfam01551
395965008956	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
395965008957	active site
395965008958	HIGH motif; other site
395965008959	nucleotide binding site [chemical binding]; other site
395965008960	active site
395965008961	KMSKS motif; other site
395965008962	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
395965008963	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
395965008964	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
395965008965	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
395965008966	minor groove reading motif; other site
395965008967	helix-hairpin-helix signature motif; other site
395965008968	substrate binding pocket [chemical binding]; other site
395965008969	active site
395965008970	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
395965008971	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
395965008972	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820
395965008973	methionine sulfoxide reductase A; Provisional; Region: PRK00058
395965008974	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
395965008975	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
395965008976	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
395965008977	Protein of unknown function (DUF423); Region: DUF423; cl01008
395965008978	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395965008979	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965008980	active site
395965008981	phosphorylation site [posttranslational modification]
395965008982	intermolecular recognition site; other site
395965008983	dimerization interface [polypeptide binding]; other site
395965008984	AsmA family; Region: AsmA; pfam05170
395965008985	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
395965008986	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395965008987	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
395965008988	ligand binding site [chemical binding]; other site
395965008989	flexible hinge region; other site
395965008990	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
395965008991	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
395965008992	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
395965008993	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395965008994	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395965008995	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
395965008996	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395965008997	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395965008998	ligand binding site [chemical binding]; other site
395965008999	flexible hinge region; other site
395965009000	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395965009001	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395965009002	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965009003	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965009004	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395965009005	Protein export membrane protein; Region: SecD_SecF; cl14618
395965009006	SnoaL-like domain; Region: SnoaL_2; pfam12680
395965009007	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
395965009008	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
395965009009	Response regulator receiver domain; Region: Response_reg; pfam00072
395965009010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965009011	active site
395965009012	phosphorylation site [posttranslational modification]
395965009013	intermolecular recognition site; other site
395965009014	dimerization interface [polypeptide binding]; other site
395965009015	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965009016	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965009017	oxidoreductase; Provisional; Region: PRK06196
395965009018	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
395965009019	putative NAD(P) binding site [chemical binding]; other site
395965009020	active site
395965009021	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
395965009022	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
395965009023	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
395965009024	DNA binding residues [nucleotide binding]
395965009025	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
395965009026	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
395965009027	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
395965009028	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
395965009029	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395965009030	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395965009031	Condensation domain; Region: Condensation; pfam00668
395965009032	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
395965009033	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
395965009034	acyl-activating enzyme (AAE) consensus motif; other site
395965009035	AMP binding site [chemical binding]; other site
395965009036	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
395965009037	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
395965009038	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
395965009039	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
395965009040	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
395965009041	putative efflux protein, MATE family; Region: matE; TIGR00797
395965009042	hypothetical protein; Provisional; Region: PRK05968
395965009043	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
395965009044	homodimer interface [polypeptide binding]; other site
395965009045	substrate-cofactor binding pocket; other site
395965009046	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965009047	catalytic residue [active]
395965009048	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
395965009049	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
395965009050	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
395965009051	ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049
395965009052	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395965009053	N-terminal plug; other site
395965009054	ligand-binding site [chemical binding]; other site
395965009055	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
395965009056	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
395965009057	[4Fe-4S] binding site [ion binding]; other site
395965009058	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
395965009059	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
395965009060	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
395965009061	molybdopterin cofactor binding site; other site
395965009062	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
395965009063	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
395965009064	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
395965009065	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
395965009066	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
395965009067	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
395965009068	Predicted permease; Region: DUF318; cl17795
395965009069	selenophosphate synthetase; Provisional; Region: PRK00943
395965009070	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
395965009071	dimerization interface [polypeptide binding]; other site
395965009072	putative ATP binding site [chemical binding]; other site
395965009073	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
395965009074	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
395965009075	G1 box; other site
395965009076	putative GEF interaction site [polypeptide binding]; other site
395965009077	GTP/Mg2+ binding site [chemical binding]; other site
395965009078	Switch I region; other site
395965009079	G2 box; other site
395965009080	G3 box; other site
395965009081	Switch II region; other site
395965009082	G4 box; other site
395965009083	G5 box; other site
395965009084	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
395965009085	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
395965009086	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
395965009087	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
395965009088	Sel1-like repeats; Region: SEL1; smart00671
395965009089	selenocysteine synthase; Provisional; Region: PRK04311
395965009090	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
395965009091	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
395965009092	Part of AAA domain; Region: AAA_19; pfam13245
395965009093	Family description; Region: UvrD_C_2; pfam13538
395965009094	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395965009095	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395965009096	active site
395965009097	catalytic tetrad [active]
395965009098	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
395965009099	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
395965009100	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
395965009101	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965009102	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965009103	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395965009104	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965009105	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
395965009106	putative effector binding pocket; other site
395965009107	dimerization interface [polypeptide binding]; other site
395965009108	Fusaric acid resistance protein family; Region: FUSC; pfam04632
395965009109	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
395965009110	Autoinducer binding domain; Region: Autoind_bind; pfam03472
395965009111	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395965009112	DNA binding residues [nucleotide binding]
395965009113	dimerization interface [polypeptide binding]; other site
395965009114	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
395965009115	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
395965009116	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
395965009117	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
395965009118	BA14K-like protein; Region: BA14K; pfam07886
395965009119	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
395965009120	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
395965009121	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965009122	S-adenosylmethionine binding site [chemical binding]; other site
395965009123	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
395965009124	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
395965009125	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
395965009126	short chain dehydrogenase; Provisional; Region: PRK06500
395965009127	classical (c) SDRs; Region: SDR_c; cd05233
395965009128	NAD(P) binding site [chemical binding]; other site
395965009129	active site
395965009130	short chain dehydrogenase; Provisional; Region: PRK06500
395965009131	classical (c) SDRs; Region: SDR_c; cd05233
395965009132	NAD(P) binding site [chemical binding]; other site
395965009133	active site
395965009134	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395965009135	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965009136	LysR substrate binding domain; Region: LysR_substrate; pfam03466
395965009137	dimerization interface [polypeptide binding]; other site
395965009138	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
395965009139	Transposase; Region: HTH_Tnp_1; pfam01527
395965009140	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
395965009141	Cytochrome c; Region: Cytochrom_C; pfam00034
395965009142	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
395965009143	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395965009144	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
395965009145	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395965009146	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
395965009147	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111
395965009148	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
395965009149	Carboxylesterase family; Region: COesterase; pfam00135
395965009150	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
395965009151	substrate binding pocket [chemical binding]; other site
395965009152	catalytic triad [active]
395965009153	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
395965009154	catalytic site [active]
395965009155	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
395965009156	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
395965009157	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
395965009158	active site
395965009159	catalytic site [active]
395965009160	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
395965009161	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
395965009162	Cytochrome c; Region: Cytochrom_C; pfam00034
395965009163	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
395965009164	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
395965009165	D-pathway; other site
395965009166	Putative ubiquinol binding site [chemical binding]; other site
395965009167	Low-spin heme (heme b) binding site [chemical binding]; other site
395965009168	Putative water exit pathway; other site
395965009169	Binuclear center (heme o3/CuB) [ion binding]; other site
395965009170	K-pathway; other site
395965009171	Putative proton exit pathway; other site
395965009172	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
395965009173	Subunit I/III interface [polypeptide binding]; other site
395965009174	Cytochrome c; Region: Cytochrom_C; pfam00034
395965009175	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
395965009176	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
395965009177	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
395965009178	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395965009179	substrate binding pocket [chemical binding]; other site
395965009180	membrane-bound complex binding site; other site
395965009181	hinge residues; other site
395965009182	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
395965009183	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
395965009184	Trp docking motif [polypeptide binding]; other site
395965009185	dimer interface [polypeptide binding]; other site
395965009186	active site
395965009187	small subunit binding site [polypeptide binding]; other site
395965009188	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
395965009189	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
395965009190	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965009191	S-adenosylmethionine binding site [chemical binding]; other site
395965009192	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
395965009193	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
395965009194	malonyl-CoA binding site [chemical binding]; other site
395965009195	dimer interface [polypeptide binding]; other site
395965009196	active site
395965009197	product binding site; other site
395965009198	Transposase; Region: HTH_Tnp_1; cl17663
395965009199	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
395965009200	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395965009201	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965009202	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965009203	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965009204	D-galactonate transporter; Region: 2A0114; TIGR00893
395965009205	putative substrate translocation pore; other site
395965009206	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
395965009207	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
395965009208	homodimer interface [polypeptide binding]; other site
395965009209	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965009210	catalytic residue [active]
395965009211	Transcriptional regulators [Transcription]; Region: GntR; COG1802
395965009212	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
395965009213	DNA-binding site [nucleotide binding]; DNA binding site
395965009214	FCD domain; Region: FCD; pfam07729
395965009215	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
395965009216	FAD binding domain; Region: FAD_binding_4; pfam01565
395965009217	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
395965009218	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
395965009219	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
395965009220	dimer interface [polypeptide binding]; other site
395965009221	active site
395965009222	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395965009223	substrate binding site [chemical binding]; other site
395965009224	catalytic residue [active]
395965009225	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
395965009226	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
395965009227	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
395965009228	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965009229	active site
395965009230	phosphorylation site [posttranslational modification]
395965009231	intermolecular recognition site; other site
395965009232	dimerization interface [polypeptide binding]; other site
395965009233	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395965009234	DNA binding site [nucleotide binding]
395965009235	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395965009236	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395965009237	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395965009238	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965009239	HAMP domain; Region: HAMP; pfam00672
395965009240	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395965009241	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965009242	ATP binding site [chemical binding]; other site
395965009243	Mg2+ binding site [ion binding]; other site
395965009244	G-X-G motif; other site
395965009245	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
395965009246	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
395965009247	catalytic site [active]
395965009248	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
395965009249	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
395965009250	molybdopterin cofactor binding site; other site
395965009251	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965009252	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965009253	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
395965009254	Predicted deacylase [General function prediction only]; Region: COG3608
395965009255	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
395965009256	putative active site [active]
395965009257	Zn binding site [ion binding]; other site
395965009258	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
395965009259	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
395965009260	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965009261	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965009262	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
395965009263	G5 box; other site
395965009264	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
395965009265	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
395965009266	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
395965009267	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
395965009268	catalytic Zn binding site [ion binding]; other site
395965009269	NAD binding site [chemical binding]; other site
395965009270	structural Zn binding site [ion binding]; other site
395965009271	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
395965009272	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
395965009273	acyl-activating enzyme (AAE) consensus motif; other site
395965009274	putative AMP binding site [chemical binding]; other site
395965009275	putative active site [active]
395965009276	putative CoA binding site [chemical binding]; other site
395965009277	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
395965009278	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395965009279	NAD(P) binding site [chemical binding]; other site
395965009280	catalytic residues [active]
395965009281	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
395965009282	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
395965009283	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
395965009284	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395965009285	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395965009286	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
395965009287	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
395965009288	carboxyltransferase (CT) interaction site; other site
395965009289	biotinylation site [posttranslational modification]; other site
395965009290	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
395965009291	putative active site [active]
395965009292	putative catalytic site [active]
395965009293	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
395965009294	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
395965009295	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
395965009296	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
395965009297	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
395965009298	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
395965009299	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
395965009300	GAF domain; Region: GAF; pfam01590
395965009301	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
395965009302	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
395965009303	peptidase domain interface [polypeptide binding]; other site
395965009304	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
395965009305	active site
395965009306	catalytic triad [active]
395965009307	calcium binding site [ion binding]; other site
395965009308	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
395965009309	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
395965009310	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965009311	putative substrate translocation pore; other site
395965009312	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965009313	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
395965009314	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965009315	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965009316	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965009317	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965009318	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
395965009319	putative catalytic site [active]
395965009320	putative phosphate binding site [ion binding]; other site
395965009321	active site
395965009322	metal binding site A [ion binding]; metal-binding site
395965009323	DNA binding site [nucleotide binding]
395965009324	putative AP binding site [nucleotide binding]; other site
395965009325	putative metal binding site B [ion binding]; other site
395965009326	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
395965009327	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395965009328	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
395965009329	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
395965009330	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
395965009331	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
395965009332	nitrile hydratase, alpha subunit; Region: nitrile_alph; TIGR01323
395965009333	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
395965009334	nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889
395965009335	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
395965009336	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
395965009337	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
395965009338	conserved cys residue [active]
395965009339	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395965009340	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
395965009341	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
395965009342	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395965009343	Walker A/P-loop; other site
395965009344	ATP binding site [chemical binding]; other site
395965009345	Q-loop/lid; other site
395965009346	ABC transporter signature motif; other site
395965009347	Walker B; other site
395965009348	D-loop; other site
395965009349	H-loop/switch region; other site
395965009350	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
395965009351	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
395965009352	ABC-ATPase subunit  interface; other site
395965009353	dimer interface [polypeptide binding]; other site
395965009354	putative PBP binding regions; other site
395965009355	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
395965009356	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
395965009357	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
395965009358	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
395965009359	N-terminal plug; other site
395965009360	ligand-binding site [chemical binding]; other site
395965009361	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
395965009362	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
395965009363	intersubunit interface [polypeptide binding]; other site
395965009364	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395965009365	PAS domain; Region: PAS_9; pfam13426
395965009366	putative active site [active]
395965009367	heme pocket [chemical binding]; other site
395965009368	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965009369	dimer interface [polypeptide binding]; other site
395965009370	phosphorylation site [posttranslational modification]
395965009371	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965009372	ATP binding site [chemical binding]; other site
395965009373	Mg2+ binding site [ion binding]; other site
395965009374	G-X-G motif; other site
395965009375	cell division protein MraZ; Reviewed; Region: PRK00326
395965009376	MraZ protein; Region: MraZ; pfam02381
395965009377	MraW methylase family; Region: Methyltransf_5; cl17771
395965009378	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
395965009379	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
395965009380	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
395965009381	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
395965009382	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
395965009383	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
395965009384	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
395965009385	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395965009386	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
395965009387	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
395965009388	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
395965009389	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395965009390	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
395965009391	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
395965009392	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
395965009393	Mg++ binding site [ion binding]; other site
395965009394	putative catalytic motif [active]
395965009395	putative substrate binding site [chemical binding]; other site
395965009396	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
395965009397	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
395965009398	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395965009399	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
395965009400	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
395965009401	putative active site [active]
395965009402	homotetrameric interface [polypeptide binding]; other site
395965009403	cell division protein FtsW; Region: ftsW; TIGR02614
395965009404	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
395965009405	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
395965009406	active site
395965009407	homodimer interface [polypeptide binding]; other site
395965009408	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
395965009409	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
395965009410	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
395965009411	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
395965009412	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
395965009413	FAD binding domain; Region: FAD_binding_4; pfam01565
395965009414	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
395965009415	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
395965009416	GIY-YIG motif/motif A; other site
395965009417	putative active site [active]
395965009418	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
395965009419	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
395965009420	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395965009421	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
395965009422	Cell division protein FtsQ; Region: FtsQ; pfam03799
395965009423	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
395965009424	Cell division protein FtsA; Region: FtsA; smart00842
395965009425	Cell division protein FtsA; Region: FtsA; pfam14450
395965009426	cell division protein FtsZ; Validated; Region: PRK09330
395965009427	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
395965009428	nucleotide binding site [chemical binding]; other site
395965009429	SulA interaction site; other site
395965009430	Pupal cuticle protein C1; Region: Cuticle_3; pfam11018
395965009431	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
395965009432	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
395965009433	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
395965009434	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
395965009435	Walker A/P-loop; other site
395965009436	ATP binding site [chemical binding]; other site
395965009437	Q-loop/lid; other site
395965009438	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
395965009439	ABC transporter signature motif; other site
395965009440	Walker B; other site
395965009441	D-loop; other site
395965009442	H-loop/switch region; other site
395965009443	quinohemoprotein amine dehydrogenase, beta subunit; Region: QH_beta; TIGR03907
395965009444	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
395965009445	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
395965009446	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
395965009447	nucleotide binding pocket [chemical binding]; other site
395965009448	K-X-D-G motif; other site
395965009449	catalytic site [active]
395965009450	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
395965009451	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
395965009452	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
395965009453	Dimer interface [polypeptide binding]; other site
395965009454	BRCT sequence motif; other site
395965009455	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
395965009456	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
395965009457	Sulfatase; Region: Sulfatase; cl17466
395965009458	PRC-barrel domain; Region: PRC; pfam05239
395965009459	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
395965009460	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
395965009461	catalytic residues [active]
395965009462	central insert; other site
395965009463	heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141
395965009464	heme exporter protein CcmC; Region: ccmC; TIGR01191
395965009465	heme exporter protein CcmB; Region: ccmB; TIGR01190
395965009466	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
395965009467	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395965009468	Walker A/P-loop; other site
395965009469	ATP binding site [chemical binding]; other site
395965009470	Q-loop/lid; other site
395965009471	ABC transporter signature motif; other site
395965009472	Walker B; other site
395965009473	D-loop; other site
395965009474	H-loop/switch region; other site
395965009475	aconitate hydratase; Validated; Region: PRK09277
395965009476	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
395965009477	substrate binding site [chemical binding]; other site
395965009478	ligand binding site [chemical binding]; other site
395965009479	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
395965009480	substrate binding site [chemical binding]; other site
395965009481	tartrate dehydrogenase; Region: TTC; TIGR02089
395965009482	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
395965009483	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
395965009484	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
395965009485	Cupin domain; Region: Cupin_2; cl17218
395965009486	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
395965009487	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
395965009488	hypothetical protein; Provisional; Region: PRK05415
395965009489	Domain of unknown function (DUF697); Region: DUF697; cl12064
395965009490	YcjX-like family, DUF463; Region: DUF463; pfam04317
395965009491	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
395965009492	catalytic core [active]
395965009493	Phasin protein; Region: Phasin_2; pfam09361
395965009494	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
395965009495	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
395965009496	motif 1; other site
395965009497	active site
395965009498	motif 2; other site
395965009499	motif 3; other site
395965009500	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
395965009501	recombinase A; Provisional; Region: recA; PRK09354
395965009502	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
395965009503	hexamer interface [polypeptide binding]; other site
395965009504	Walker A motif; other site
395965009505	ATP binding site [chemical binding]; other site
395965009506	Walker B motif; other site
395965009507	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
395965009508	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
395965009509	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965009510	dimer interface [polypeptide binding]; other site
395965009511	phosphorylation site [posttranslational modification]
395965009512	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965009513	ATP binding site [chemical binding]; other site
395965009514	Mg2+ binding site [ion binding]; other site
395965009515	G-X-G motif; other site
395965009516	Response regulator receiver domain; Region: Response_reg; pfam00072
395965009517	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965009518	active site
395965009519	phosphorylation site [posttranslational modification]
395965009520	intermolecular recognition site; other site
395965009521	dimerization interface [polypeptide binding]; other site
395965009522	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
395965009523	isocitrate dehydrogenase; Validated; Region: PRK08299
395965009524	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
395965009525	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
395965009526	active site
395965009527	metal binding site [ion binding]; metal-binding site
395965009528	Uncharacterized conserved protein [Function unknown]; Region: COG3025
395965009529	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
395965009530	putative active site [active]
395965009531	putative metal binding residues [ion binding]; other site
395965009532	signature motif; other site
395965009533	putative triphosphate binding site [ion binding]; other site
395965009534	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
395965009535	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
395965009536	putative active site pocket [active]
395965009537	dimerization interface [polypeptide binding]; other site
395965009538	putative catalytic residue [active]
395965009539	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093
395965009540	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
395965009541	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
395965009542	Bacterial sugar transferase; Region: Bac_transf; pfam02397
395965009543	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
395965009544	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
395965009545	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
395965009546	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
395965009547	active site
395965009548	dimer interface [polypeptide binding]; other site
395965009549	motif 1; other site
395965009550	motif 2; other site
395965009551	motif 3; other site
395965009552	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
395965009553	anticodon binding site; other site
395965009554	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
395965009555	DNA binding residues [nucleotide binding]
395965009556	dimerization interface [polypeptide binding]; other site
395965009557	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
395965009558	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
395965009559	putative acyl-acceptor binding pocket; other site
395965009560	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
395965009561	putative DNA binding site [nucleotide binding]; other site
395965009562	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965009563	S-adenosylmethionine binding site [chemical binding]; other site
395965009564	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
395965009565	FAD binding site [chemical binding]; other site
395965009566	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
395965009567	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
395965009568	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
395965009569	substrate binding pocket [chemical binding]; other site
395965009570	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
395965009571	B12 binding site [chemical binding]; other site
395965009572	cobalt ligand [ion binding]; other site
395965009573	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
395965009574	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
395965009575	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
395965009576	amidase catalytic site [active]
395965009577	Zn binding residues [ion binding]; other site
395965009578	substrate binding site [chemical binding]; other site
395965009579	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395965009580	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
395965009581	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395965009582	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395965009583	catalytic loop [active]
395965009584	iron binding site [ion binding]; other site
395965009585	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
395965009586	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395965009587	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395965009588	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
395965009589	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
395965009590	active site
395965009591	(T/H)XGH motif; other site
395965009592	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
395965009593	active site
395965009594	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
395965009595	active site
395965009596	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
395965009597	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
395965009598	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
395965009599	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
395965009600	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395965009601	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
395965009602	putative C-terminal domain interface [polypeptide binding]; other site
395965009603	putative GSH binding site (G-site) [chemical binding]; other site
395965009604	putative dimer interface [polypeptide binding]; other site
395965009605	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
395965009606	putative N-terminal domain interface [polypeptide binding]; other site
395965009607	putative dimer interface [polypeptide binding]; other site
395965009608	putative substrate binding pocket (H-site) [chemical binding]; other site
395965009609	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
395965009610	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
395965009611	active site
395965009612	Transglycosylase SLT domain; Region: SLT_2; pfam13406
395965009613	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395965009614	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395965009615	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
395965009616	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
395965009617	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
395965009618	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
395965009619	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965009620	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965009621	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
395965009622	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395965009623	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395965009624	catalytic residue [active]
395965009625	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
395965009626	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
395965009627	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
395965009628	L-aspartate oxidase; Provisional; Region: PRK06175
395965009629	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
395965009630	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
395965009631	putative SdhC subunit interface [polypeptide binding]; other site
395965009632	putative proximal heme binding site [chemical binding]; other site
395965009633	putative Iron-sulfur protein interface [polypeptide binding]; other site
395965009634	putative proximal quinone binding site; other site
395965009635	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
395965009636	Iron-sulfur protein interface; other site
395965009637	proximal quinone binding site [chemical binding]; other site
395965009638	SdhD (CybS) interface [polypeptide binding]; other site
395965009639	proximal heme binding site [chemical binding]; other site
395965009640	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
395965009641	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
395965009642	YGGT family; Region: YGGT; pfam02325
395965009643	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
395965009644	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
395965009645	HsdM N-terminal domain; Region: HsdM_N; pfam12161
395965009646	Methyltransferase domain; Region: Methyltransf_26; pfam13659
395965009647	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
395965009648	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
395965009649	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
395965009650	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
395965009651	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
395965009652	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
395965009653	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395965009654	ATP binding site [chemical binding]; other site
395965009655	putative Mg++ binding site [ion binding]; other site
395965009656	transposase/IS protein; Provisional; Region: PRK09183
395965009657	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
395965009658	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
395965009659	active site
395965009660	Transposase; Region: HTH_Tnp_1; cl17663
395965009661	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
395965009662	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395965009663	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
395965009664	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
395965009665	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
395965009666	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
395965009667	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
395965009668	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
395965009669	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
395965009670	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
395965009671	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
395965009672	PAS domain S-box; Region: sensory_box; TIGR00229
395965009673	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395965009674	putative active site [active]
395965009675	heme pocket [chemical binding]; other site
395965009676	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
395965009677	PAS domain; Region: PAS_9; pfam13426
395965009678	putative active site [active]
395965009679	heme pocket [chemical binding]; other site
395965009680	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
395965009681	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965009682	dimer interface [polypeptide binding]; other site
395965009683	phosphorylation site [posttranslational modification]
395965009684	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965009685	ATP binding site [chemical binding]; other site
395965009686	G-X-G motif; other site
395965009687	Response regulator receiver domain; Region: Response_reg; pfam00072
395965009688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965009689	active site
395965009690	phosphorylation site [posttranslational modification]
395965009691	intermolecular recognition site; other site
395965009692	dimerization interface [polypeptide binding]; other site
395965009693	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
395965009694	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
395965009695	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
395965009696	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
395965009697	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
395965009698	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965009699	S-adenosylmethionine binding site [chemical binding]; other site
395965009700	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
395965009701	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
395965009702	active site
395965009703	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
395965009704	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
395965009705	heme binding pocket [chemical binding]; other site
395965009706	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
395965009707	domain interactions; other site
395965009708	Carboxylesterase family; Region: COesterase; pfam00135
395965009709	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
395965009710	substrate binding pocket [chemical binding]; other site
395965009711	catalytic triad [active]
395965009712	Beta-lactamase; Region: Beta-lactamase; pfam00144
395965009713	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
395965009714	Beta-lactamase; Region: Beta-lactamase; cl17358
395965009715	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
395965009716	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
395965009717	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
395965009718	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
395965009719	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
395965009720	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
395965009721	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395965009722	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
395965009723	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
395965009724	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
395965009725	Amino acid permease; Region: AA_permease_2; pfam13520
395965009726	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
395965009727	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
395965009728	FMN-binding pocket [chemical binding]; other site
395965009729	flavin binding motif; other site
395965009730	phosphate binding motif [ion binding]; other site
395965009731	beta-alpha-beta structure motif; other site
395965009732	NAD binding pocket [chemical binding]; other site
395965009733	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395965009734	catalytic loop [active]
395965009735	iron binding site [ion binding]; other site
395965009736	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
395965009737	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
395965009738	classical (c) SDRs; Region: SDR_c; cd05233
395965009739	NAD(P) binding site [chemical binding]; other site
395965009740	active site
395965009741	transcriptional regulator; Provisional; Region: PRK10632
395965009742	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965009743	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395965009744	dimerization interface [polypeptide binding]; other site
395965009745	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
395965009746	oxidoreductase; Provisional; Region: PRK10015
395965009747	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395965009748	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
395965009749	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
395965009750	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
395965009751	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
395965009752	Ligand binding site [chemical binding]; other site
395965009753	Electron transfer flavoprotein domain; Region: ETF; pfam01012
395965009754	nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810
395965009755	serine O-acetyltransferase; Region: cysE; TIGR01172
395965009756	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
395965009757	trimer interface [polypeptide binding]; other site
395965009758	active site
395965009759	substrate binding site [chemical binding]; other site
395965009760	CoA binding site [chemical binding]; other site
395965009761	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
395965009762	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
395965009763	active site
395965009764	catalytic residues [active]
395965009765	metal binding site [ion binding]; metal-binding site
395965009766	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
395965009767	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
395965009768	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395965009769	catalytic residue [active]
395965009770	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
395965009771	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
395965009772	trimerization site [polypeptide binding]; other site
395965009773	active site
395965009774	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
395965009775	NifU-like domain; Region: NifU; pfam01106
395965009776	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
395965009777	NifQ; Region: NifQ; pfam04891
395965009778	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
395965009779	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
395965009780	Rop-like; Region: Rop-like; pfam05082
395965009781	probable nitrogen fixation protein; Region: TIGR02935
395965009782	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
395965009783	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
395965009784	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
395965009785	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
395965009786	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
395965009787	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
395965009788	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
395965009789	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
395965009790	MoFe protein beta/alpha subunit interactions; other site
395965009791	Beta subunit P cluster binding residues; other site
395965009792	MoFe protein beta subunit/Fe protein contacts; other site
395965009793	MoFe protein dimer/ dimer interactions; other site
395965009794	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
395965009795	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
395965009796	MoFe protein alpha/beta subunit interactions; other site
395965009797	Alpha subunit P cluster binding residues; other site
395965009798	FeMoco binding residues [chemical binding]; other site
395965009799	MoFe protein alpha subunit/Fe protein contacts; other site
395965009800	MoFe protein dimer/ dimer interactions; other site
395965009801	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
395965009802	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
395965009803	Nucleotide-binding sites [chemical binding]; other site
395965009804	Walker A motif; other site
395965009805	Switch I region of nucleotide binding site; other site
395965009806	Fe4S4 binding sites [ion binding]; other site
395965009807	Switch II region of nucleotide binding site; other site
395965009808	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
395965009809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965009810	active site
395965009811	phosphorylation site [posttranslational modification]
395965009812	intermolecular recognition site; other site
395965009813	dimerization interface [polypeptide binding]; other site
395965009814	SIR2-like domain; Region: SIR2_2; pfam13289
395965009815	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395965009816	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395965009817	catalytic loop [active]
395965009818	iron binding site [ion binding]; other site
395965009819	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
395965009820	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
395965009821	inhibitor-cofactor binding pocket; inhibition site
395965009822	pyridoxal 5'-phosphate binding site [chemical binding]; other site
395965009823	catalytic residue [active]
395965009824	NifT/FixU protein; Region: NifT; pfam06988
395965009825	NifZ domain; Region: NifZ; pfam04319
395965009826	NifZ domain; Region: NifZ; pfam04319
395965009827	LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484
395965009828	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
395965009829	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
395965009830	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
395965009831	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
395965009832	FeS/SAM binding site; other site
395965009833	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
395965009834	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
395965009835	Nif-specific regulatory protein; Region: nifA; TIGR01817
395965009836	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
395965009837	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965009838	Walker A motif; other site
395965009839	ATP binding site [chemical binding]; other site
395965009840	Walker B motif; other site
395965009841	arginine finger; other site
395965009842	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395965009843	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
395965009844	apolar tunnel; other site
395965009845	heme binding site [chemical binding]; other site
395965009846	dimerization interface [polypeptide binding]; other site
395965009847	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
395965009848	metal binding site 2 [ion binding]; metal-binding site
395965009849	putative DNA binding helix; other site
395965009850	metal binding site 1 [ion binding]; metal-binding site
395965009851	dimer interface [polypeptide binding]; other site
395965009852	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
395965009853	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
395965009854	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
395965009855	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
395965009856	putative dimer interface [polypeptide binding]; other site
395965009857	[2Fe-2S] cluster binding site [ion binding]; other site
395965009858	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
395965009859	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
395965009860	SLBB domain; Region: SLBB; pfam10531
395965009861	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
395965009862	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
395965009863	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395965009864	catalytic loop [active]
395965009865	iron binding site [ion binding]; other site
395965009866	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
395965009867	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
395965009868	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
395965009869	[4Fe-4S] binding site [ion binding]; other site
395965009870	molybdopterin cofactor binding site; other site
395965009871	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
395965009872	molybdopterin cofactor binding site; other site
395965009873	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
395965009874	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
395965009875	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
395965009876	Low-spin heme binding site [chemical binding]; other site
395965009877	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
395965009878	Putative water exit pathway; other site
395965009879	Binuclear center (active site) [active]
395965009880	Putative proton exit pathway; other site
395965009881	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
395965009882	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
395965009883	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
395965009884	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
395965009885	Cytochrome c; Region: Cytochrom_C; pfam00034
395965009886	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
395965009887	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
395965009888	4Fe-4S binding domain; Region: Fer4_5; pfam12801
395965009889	4Fe-4S binding domain; Region: Fer4_6; pfam12837
395965009890	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
395965009891	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
395965009892	FixH; Region: FixH; pfam05751
395965009893	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
395965009894	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
395965009895	metal-binding site [ion binding]
395965009896	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395965009897	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
395965009898	excinuclease ABC subunit B; Provisional; Region: PRK05298
395965009899	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
395965009900	ATP binding site [chemical binding]; other site
395965009901	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
395965009902	nucleotide binding region [chemical binding]; other site
395965009903	ATP-binding site [chemical binding]; other site
395965009904	Ultra-violet resistance protein B; Region: UvrB; pfam12344
395965009905	Transglycosylase SLT domain; Region: SLT_2; pfam13406
395965009906	murein hydrolase B; Provisional; Region: PRK10760; cl17906
395965009907	Transglycosylase SLT domain; Region: SLT_2; pfam13406
395965009908	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
395965009909	N-acetyl-D-glucosamine binding site [chemical binding]; other site
395965009910	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
395965009911	MPT binding site; other site
395965009912	trimer interface [polypeptide binding]; other site
395965009913	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
395965009914	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
395965009915	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
395965009916	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395965009917	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
395965009918	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395965009919	Uncharacterized conserved protein [Function unknown]; Region: COG4274
395965009920	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
395965009921	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
395965009922	C-terminal domain interface [polypeptide binding]; other site
395965009923	GSH binding site (G-site) [chemical binding]; other site
395965009924	dimer interface [polypeptide binding]; other site
395965009925	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
395965009926	N-terminal domain interface [polypeptide binding]; other site
395965009927	dimer interface [polypeptide binding]; other site
395965009928	substrate binding pocket (H-site) [chemical binding]; other site
395965009929	epoxyqueuosine reductase; Region: TIGR00276
395965009930	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
395965009931	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
395965009932	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
395965009933	putative NAD(P) binding site [chemical binding]; other site
395965009934	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395965009935	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965009936	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
395965009937	putative effector binding pocket; other site
395965009938	putative dimerization interface [polypeptide binding]; other site
395965009939	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
395965009940	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
395965009941	active site
395965009942	catalytic tetrad [active]
395965009943	PAS fold; Region: PAS_2; pfam08446
395965009944	GAF domain; Region: GAF; pfam01590
395965009945	Phytochrome region; Region: PHY; pfam00360
395965009946	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
395965009947	Histidine kinase; Region: HisKA_2; pfam07568
395965009948	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
395965009949	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
395965009950	active site
395965009951	Zn binding site [ion binding]; other site
395965009952	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
395965009953	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
395965009954	catalytic residues [active]
395965009955	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
395965009956	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
395965009957	GSH binding site [chemical binding]; other site
395965009958	catalytic residues [active]
395965009959	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
395965009960	metal binding site 2 [ion binding]; metal-binding site
395965009961	putative DNA binding helix; other site
395965009962	metal binding site 1 [ion binding]; metal-binding site
395965009963	ferrochelatase; Reviewed; Region: hemH; PRK00035
395965009964	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
395965009965	C-terminal domain interface [polypeptide binding]; other site
395965009966	active site
395965009967	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
395965009968	active site
395965009969	N-terminal domain interface [polypeptide binding]; other site
395965009970	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
395965009971	hypothetical protein; Provisional; Region: PRK05409
395965009972	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
395965009973	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
395965009974	NAD binding site [chemical binding]; other site
395965009975	homodimer interface [polypeptide binding]; other site
395965009976	active site
395965009977	substrate binding site [chemical binding]; other site
395965009978	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
395965009979	active site
395965009980	tetramer interface; other site
395965009981	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
395965009982	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
395965009983	FMN binding site [chemical binding]; other site
395965009984	active site
395965009985	substrate binding site [chemical binding]; other site
395965009986	catalytic residue [active]
395965009987	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
395965009988	N-formylglutamate amidohydrolase; Region: FGase; cl01522
395965009989	Protein of unknown function (DUF1036); Region: DUF1036; pfam06282
395965009990	pyruvate kinase; Provisional; Region: PRK06247
395965009991	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
395965009992	domain interfaces; other site
395965009993	active site
395965009994	Transglycosylase; Region: Transgly; pfam00912
395965009995	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
395965009996	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
395965009997	DNA polymerase III subunit beta; Validated; Region: PRK05643
395965009998	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
395965009999	putative DNA binding surface [nucleotide binding]; other site
395965010000	dimer interface [polypeptide binding]; other site
395965010001	beta-clamp/clamp loader binding surface; other site
395965010002	beta-clamp/translesion DNA polymerase binding surface; other site
395965010003	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
395965010004	putative active site [active]
395965010005	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
395965010006	elongation factor P; Validated; Region: PRK00529
395965010007	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
395965010008	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
395965010009	RNA binding site [nucleotide binding]; other site
395965010010	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
395965010011	RNA binding site [nucleotide binding]; other site
395965010012	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
395965010013	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
395965010014	active site
395965010015	dimerization interface [polypeptide binding]; other site
395965010016	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
395965010017	hypothetical protein; Provisional; Region: PRK09256
395965010018	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
395965010019	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395965010020	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965010021	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
395965010022	dimerization interface [polypeptide binding]; other site
395965010023	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
395965010024	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
395965010025	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
395965010026	Protein of unknown function (DUF3072); Region: DUF3072; pfam11272
395965010027	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
395965010028	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
395965010029	active site
395965010030	DNA binding site [nucleotide binding]
395965010031	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
395965010032	DNA binding site [nucleotide binding]
395965010033	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
395965010034	MOSC domain; Region: MOSC; pfam03473
395965010035	3-alpha domain; Region: 3-alpha; pfam03475
395965010036	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965010037	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965010038	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
395965010039	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
395965010040	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
395965010041	Erythromycin esterase; Region: Erythro_esteras; pfam05139
395965010042	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
395965010043	glutaminase; Provisional; Region: PRK00971
395965010044	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
395965010045	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965010046	Walker A motif; other site
395965010047	ATP binding site [chemical binding]; other site
395965010048	Walker B motif; other site
395965010049	arginine finger; other site
395965010050	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395965010051	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
395965010052	ATP-NAD kinase; Region: NAD_kinase; pfam01513
395965010053	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
395965010054	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
395965010055	tetramer interface [polypeptide binding]; other site
395965010056	TPP-binding site [chemical binding]; other site
395965010057	heterodimer interface [polypeptide binding]; other site
395965010058	phosphorylation loop region [posttranslational modification]
395965010059	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
395965010060	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
395965010061	alpha subunit interface [polypeptide binding]; other site
395965010062	TPP binding site [chemical binding]; other site
395965010063	heterodimer interface [polypeptide binding]; other site
395965010064	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
395965010065	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
395965010066	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
395965010067	E3 interaction surface; other site
395965010068	lipoyl attachment site [posttranslational modification]; other site
395965010069	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395965010070	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
395965010071	catalytic site [active]
395965010072	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
395965010073	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
395965010074	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
395965010075	Trp docking motif [polypeptide binding]; other site
395965010076	active site
395965010077	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
395965010078	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
395965010079	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
395965010080	substrate binding pocket [chemical binding]; other site
395965010081	membrane-bound complex binding site; other site
395965010082	hinge residues; other site
395965010083	Chromate transporter; Region: Chromate_transp; pfam02417
395965010084	Chromate transporter; Region: Chromate_transp; pfam02417
395965010085	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
395965010086	GTP cyclohydrolase I; Provisional; Region: PLN03044
395965010087	active site
395965010088	Response regulator receiver domain; Region: Response_reg; pfam00072
395965010089	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965010090	active site
395965010091	phosphorylation site [posttranslational modification]
395965010092	intermolecular recognition site; other site
395965010093	dimerization interface [polypeptide binding]; other site
395965010094	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395965010095	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
395965010096	ligand binding site [chemical binding]; other site
395965010097	flexible hinge region; other site
395965010098	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395965010099	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
395965010100	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
395965010101	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965010102	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965010103	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
395965010104	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
395965010105	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
395965010106	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
395965010107	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
395965010108	dimerization interface [polypeptide binding]; other site
395965010109	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
395965010110	ATP binding site [chemical binding]; other site
395965010111	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
395965010112	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
395965010113	HupF/HypC family; Region: HupF_HypC; cl00394
395965010114	Acylphosphatase; Region: Acylphosphatase; pfam00708
395965010115	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
395965010116	HypF finger; Region: zf-HYPF; pfam07503
395965010117	HypF finger; Region: zf-HYPF; pfam07503
395965010118	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
395965010119	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
395965010120	NifU-like domain; Region: NifU; cl00484
395965010121	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
395965010122	iron-sulfur cluster [ion binding]; other site
395965010123	[2Fe-2S] cluster binding site [ion binding]; other site
395965010124	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
395965010125	nickel binding site [ion binding]; other site
395965010126	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
395965010127	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
395965010128	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
395965010129	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
395965010130	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
395965010131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
395965010132	active site
395965010133	phosphorylation site [posttranslational modification]
395965010134	intermolecular recognition site; other site
395965010135	dimerization interface [polypeptide binding]; other site
395965010136	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
395965010137	Walker A motif; other site
395965010138	ATP binding site [chemical binding]; other site
395965010139	Walker B motif; other site
395965010140	arginine finger; other site
395965010141	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
395965010142	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
395965010143	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
395965010144	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
395965010145	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
395965010146	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965010147	active site
395965010148	phosphorylation site [posttranslational modification]
395965010149	intermolecular recognition site; other site
395965010150	ANTAR domain; Region: ANTAR; pfam03861
395965010151	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
395965010152	NMT1-like family; Region: NMT1_2; pfam13379
395965010153	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
395965010154	active site
395965010155	SAM binding site [chemical binding]; other site
395965010156	homodimer interface [polypeptide binding]; other site
395965010157	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
395965010158	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
395965010159	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
395965010160	[4Fe-4S] binding site [ion binding]; other site
395965010161	molybdopterin cofactor binding site; other site
395965010162	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
395965010163	molybdopterin cofactor binding site; other site
395965010164	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
395965010165	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
395965010166	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
395965010167	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
395965010168	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
395965010169	iron-sulfur cluster [ion binding]; other site
395965010170	[2Fe-2S] cluster binding site [ion binding]; other site
395965010171	short chain dehydrogenase; Provisional; Region: PRK12937
395965010172	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
395965010173	NADP binding site [chemical binding]; other site
395965010174	homodimer interface [polypeptide binding]; other site
395965010175	active site
395965010176	substrate binding site [chemical binding]; other site
395965010177	hydroxyglutarate oxidase; Provisional; Region: PRK11728
395965010178	Predicted dehydrogenase [General function prediction only]; Region: COG0579
395965010179	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
395965010180	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
395965010181	catalytic loop [active]
395965010182	iron binding site [ion binding]; other site
395965010183	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
395965010184	diiron binding motif [ion binding]; other site
395965010185	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
395965010186	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
395965010187	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
395965010188	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
395965010189	Ligand binding site [chemical binding]; other site
395965010190	Electron transfer flavoprotein domain; Region: ETF; pfam01012
395965010191	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
395965010192	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
395965010193	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
395965010194	dimer interface [polypeptide binding]; other site
395965010195	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
395965010196	active site
395965010197	metal binding site [ion binding]; metal-binding site
395965010198	glutathione binding site [chemical binding]; other site
395965010199	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
395965010200	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
395965010201	active site
395965010202	substrate binding site [chemical binding]; other site
395965010203	coenzyme B12 binding site [chemical binding]; other site
395965010204	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
395965010205	B12 binding site [chemical binding]; other site
395965010206	cobalt ligand [ion binding]; other site
395965010207	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
395965010208	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
395965010209	heterodimer interface [polypeptide binding]; other site
395965010210	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
395965010211	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395965010212	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395965010213	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
395965010214	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
395965010215	carboxyltransferase (CT) interaction site; other site
395965010216	biotinylation site [posttranslational modification]; other site
395965010217	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
395965010218	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
395965010219	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
395965010220	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
395965010221	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395965010222	non-specific DNA binding site [nucleotide binding]; other site
395965010223	salt bridge; other site
395965010224	sequence-specific DNA binding site [nucleotide binding]; other site
395965010225	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
395965010226	Domain of unknown function (DUF955); Region: DUF955; pfam06114
395965010227	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
395965010228	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
395965010229	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
395965010230	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
395965010231	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
395965010232	Walker A/P-loop; other site
395965010233	ATP binding site [chemical binding]; other site
395965010234	Q-loop/lid; other site
395965010235	ABC transporter signature motif; other site
395965010236	Walker B; other site
395965010237	D-loop; other site
395965010238	H-loop/switch region; other site
395965010239	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
395965010240	Walker A/P-loop; other site
395965010241	ATP binding site [chemical binding]; other site
395965010242	Q-loop/lid; other site
395965010243	ABC transporter signature motif; other site
395965010244	Walker B; other site
395965010245	D-loop; other site
395965010246	H-loop/switch region; other site
395965010247	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
395965010248	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
395965010249	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
395965010250	HlyD family secretion protein; Region: HlyD_3; pfam13437
395965010251	NnrU protein; Region: NnrU; pfam07298
395965010252	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
395965010253	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
395965010254	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
395965010255	active site
395965010256	catalytic site [active]
395965010257	Transcriptional regulator [Transcription]; Region: LysR; COG0583
395965010258	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
395965010259	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
395965010260	putative dimerization interface [polypeptide binding]; other site
395965010261	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
395965010262	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
395965010263	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
395965010264	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
395965010265	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
395965010266	active site
395965010267	nucleotide binding site [chemical binding]; other site
395965010268	HIGH motif; other site
395965010269	KMSKS motif; other site
395965010270	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
395965010271	cytochrome b; Provisional; Region: CYTB; MTH00119
395965010272	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
395965010273	Qi binding site; other site
395965010274	intrachain domain interface; other site
395965010275	interchain domain interface [polypeptide binding]; other site
395965010276	heme bH binding site [chemical binding]; other site
395965010277	heme bL binding site [chemical binding]; other site
395965010278	Qo binding site; other site
395965010279	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
395965010280	interchain domain interface [polypeptide binding]; other site
395965010281	intrachain domain interface; other site
395965010282	Qi binding site; other site
395965010283	Qo binding site; other site
395965010284	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
395965010285	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
395965010286	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
395965010287	[2Fe-2S] cluster binding site [ion binding]; other site
395965010288	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
395965010289	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
395965010290	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
395965010291	Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293
395965010292	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
395965010293	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
395965010294	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
395965010295	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
395965010296	quinone interaction residues [chemical binding]; other site
395965010297	active site
395965010298	catalytic residues [active]
395965010299	FMN binding site [chemical binding]; other site
395965010300	substrate binding site [chemical binding]; other site
395965010301	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
395965010302	catalytic core [active]
395965010303	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
395965010304	nitrilase; Region: PLN02798
395965010305	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
395965010306	putative active site [active]
395965010307	catalytic triad [active]
395965010308	dimer interface [polypeptide binding]; other site
395965010309	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
395965010310	peptide binding site [polypeptide binding]; other site
395965010311	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
395965010312	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
395965010313	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
395965010314	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
395965010315	diaminopimelate decarboxylase; Region: lysA; TIGR01048
395965010316	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
395965010317	active site
395965010318	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
395965010319	substrate binding site [chemical binding]; other site
395965010320	catalytic residues [active]
395965010321	dimer interface [polypeptide binding]; other site
395965010322	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
395965010323	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
395965010324	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
395965010325	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
395965010326	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
395965010327	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
395965010328	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
395965010329	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
395965010330	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
395965010331	AAA domain; Region: AAA_23; pfam13476
395965010332	Walker A/P-loop; other site
395965010333	ATP binding site [chemical binding]; other site
395965010334	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
395965010335	ABC transporter signature motif; other site
395965010336	Walker B; other site
395965010337	D-loop; other site
395965010338	H-loop/switch region; other site
395965010339	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
395965010340	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
395965010341	catalytic residues [active]
395965010342	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
395965010343	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
395965010344	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
395965010345	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
395965010346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965010347	active site
395965010348	phosphorylation site [posttranslational modification]
395965010349	intermolecular recognition site; other site
395965010350	dimerization interface [polypeptide binding]; other site
395965010351	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
395965010352	DNA binding residues [nucleotide binding]
395965010353	dimerization interface [polypeptide binding]; other site
395965010354	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
395965010355	Histidine kinase; Region: HisKA_3; pfam07730
395965010356	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965010357	ATP binding site [chemical binding]; other site
395965010358	Mg2+ binding site [ion binding]; other site
395965010359	G-X-G motif; other site
395965010360	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
395965010361	putative nucleotide binding site [chemical binding]; other site
395965010362	uridine monophosphate binding site [chemical binding]; other site
395965010363	homohexameric interface [polypeptide binding]; other site
395965010364	ribosome recycling factor; Reviewed; Region: frr; PRK00083
395965010365	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
395965010366	hinge region; other site
395965010367	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
395965010368	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
395965010369	catalytic residue [active]
395965010370	putative FPP diphosphate  binding site; other site
395965010371	putative FPP binding hydrophobic cleft; other site
395965010372	dimer interface [polypeptide binding]; other site
395965010373	putative IPP diphosphate binding site; other site
395965010374	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
395965010375	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
395965010376	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
395965010377	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
395965010378	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
395965010379	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
395965010380	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
395965010381	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
395965010382	active site
395965010383	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
395965010384	protein binding site [polypeptide binding]; other site
395965010385	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
395965010386	putative substrate binding region [chemical binding]; other site
395965010387	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
395965010388	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
395965010389	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
395965010390	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
395965010391	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
395965010392	Surface antigen; Region: Bac_surface_Ag; pfam01103
395965010393	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853
395965010394	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
395965010395	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
395965010396	trimer interface [polypeptide binding]; other site
395965010397	active site
395965010398	lipid binding site [chemical binding]; lipid-binding site
395965010399	UDP-GlcNAc binding site [chemical binding]; other site
395965010400	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
395965010401	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
395965010402	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
395965010403	NADP binding site [chemical binding]; other site
395965010404	dimer interface [polypeptide binding]; other site
395965010405	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
395965010406	Recombination protein O N terminal; Region: RecO_N; pfam11967
395965010407	Recombination protein O C terminal; Region: RecO_C; pfam02565
395965010408	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
395965010409	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965010410	Major Facilitator Superfamily; Region: MFS_1; pfam07690
395965010411	putative substrate translocation pore; other site
395965010412	Protein of unknown function (DUF983); Region: DUF983; cl02211
395965010413	Domain of unknown function DUF302; Region: DUF302; pfam03625
395965010414	ribonuclease R; Region: RNase_R; TIGR02063
395965010415	RNB domain; Region: RNB; pfam00773
395965010416	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
395965010417	RNA binding site [nucleotide binding]; other site
395965010418	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
395965010419	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
395965010420	active site
395965010421	interdomain interaction site; other site
395965010422	putative metal-binding site [ion binding]; other site
395965010423	nucleotide binding site [chemical binding]; other site
395965010424	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
395965010425	domain I; other site
395965010426	DNA binding groove [nucleotide binding]
395965010427	phosphate binding site [ion binding]; other site
395965010428	domain II; other site
395965010429	domain III; other site
395965010430	nucleotide binding site [chemical binding]; other site
395965010431	catalytic site [active]
395965010432	domain IV; other site
395965010433	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
395965010434	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
395965010435	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
395965010436	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
395965010437	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
395965010438	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
395965010439	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
395965010440	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
395965010441	dihydroorotase; Validated; Region: pyrC; PRK09357
395965010442	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
395965010443	active site
395965010444	Domain of unknown function (DUF4188); Region: DUF4188; pfam13826
395965010445	Cupin domain; Region: Cupin_2; pfam07883
395965010446	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
395965010447	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
395965010448	metal binding site [ion binding]; metal-binding site
395965010449	active site
395965010450	I-site; other site
395965010451	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
395965010452	Nitrogen regulatory protein P-II; Region: P-II; smart00938
395965010453	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
395965010454	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
395965010455	DNA protecting protein DprA; Region: dprA; TIGR00732
395965010456	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
395965010457	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
395965010458	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
395965010459	ATP-grasp domain; Region: ATP-grasp_4; cl17255
395965010460	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
395965010461	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
395965010462	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
395965010463	carboxyltransferase (CT) interaction site; other site
395965010464	biotinylation site [posttranslational modification]; other site
395965010465	Dehydroquinase class II; Region: DHquinase_II; pfam01220
395965010466	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
395965010467	trimer interface [polypeptide binding]; other site
395965010468	active site
395965010469	dimer interface [polypeptide binding]; other site
395965010470	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
395965010471	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
395965010472	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
395965010473	putative homodimer interface [polypeptide binding]; other site
395965010474	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
395965010475	heterodimer interface [polypeptide binding]; other site
395965010476	homodimer interface [polypeptide binding]; other site
395965010477	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
395965010478	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
395965010479	23S rRNA interface [nucleotide binding]; other site
395965010480	L7/L12 interface [polypeptide binding]; other site
395965010481	putative thiostrepton binding site; other site
395965010482	L25 interface [polypeptide binding]; other site
395965010483	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
395965010484	mRNA/rRNA interface [nucleotide binding]; other site
395965010485	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
395965010486	23S rRNA interface [nucleotide binding]; other site
395965010487	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
395965010488	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
395965010489	core dimer interface [polypeptide binding]; other site
395965010490	peripheral dimer interface [polypeptide binding]; other site
395965010491	L10 interface [polypeptide binding]; other site
395965010492	L11 interface [polypeptide binding]; other site
395965010493	putative EF-Tu interaction site [polypeptide binding]; other site
395965010494	putative EF-G interaction site [polypeptide binding]; other site
395965010495	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
395965010496	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
395965010497	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
395965010498	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
395965010499	RPB11 interaction site [polypeptide binding]; other site
395965010500	RPB12 interaction site [polypeptide binding]; other site
395965010501	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
395965010502	RPB3 interaction site [polypeptide binding]; other site
395965010503	RPB1 interaction site [polypeptide binding]; other site
395965010504	RPB11 interaction site [polypeptide binding]; other site
395965010505	RPB10 interaction site [polypeptide binding]; other site
395965010506	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
395965010507	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
395965010508	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
395965010509	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
395965010510	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
395965010511	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
395965010512	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
395965010513	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
395965010514	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
395965010515	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
395965010516	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
395965010517	DNA binding site [nucleotide binding]
395965010518	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
395965010519	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395965010520	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395965010521	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
395965010522	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395965010523	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395965010524	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
395965010525	S-adenosylmethionine binding site [chemical binding]; other site
395965010526	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
395965010527	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
395965010528	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
395965010529	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
395965010530	active site
395965010531	dimer interface [polypeptide binding]; other site
395965010532	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
395965010533	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
395965010534	active site
395965010535	FMN binding site [chemical binding]; other site
395965010536	substrate binding site [chemical binding]; other site
395965010537	3Fe-4S cluster binding site [ion binding]; other site
395965010538	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
395965010539	domain interface; other site
395965010540	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
395965010541	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
395965010542	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
395965010543	catalytic residue [active]
395965010544	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
395965010545	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
395965010546	putative dimer interface [polypeptide binding]; other site
395965010547	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
395965010548	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
395965010549	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
395965010550	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
395965010551	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
395965010552	active site
395965010553	catalytic triad [active]
395965010554	oxyanion hole [active]
395965010555	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
395965010556	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
395965010557	NAD(P) binding site [chemical binding]; other site
395965010558	catalytic residues [active]
395965010559	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
395965010560	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
395965010561	Sulfate transporter family; Region: Sulfate_transp; pfam00916
395965010562	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
395965010563	non-specific DNA binding site [nucleotide binding]; other site
395965010564	salt bridge; other site
395965010565	sequence-specific DNA binding site [nucleotide binding]; other site
395965010566	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
395965010567	classical (c) SDRs; Region: SDR_c; cd05233
395965010568	NAD(P) binding site [chemical binding]; other site
395965010569	active site
395965010570	Novel bacterial esterase 713 that cleaves esters on halogenated cyclic compounds; Region: Esterase_713; cd12807
395965010571	catalytic site [active]
395965010572	DnaJ chaperone protein; Provisional; Region: PTZ00100
395965010573	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
395965010574	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
395965010575	FtsX-like permease family; Region: FtsX; pfam02687
395965010576	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
395965010577	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
395965010578	Walker A/P-loop; other site
395965010579	ATP binding site [chemical binding]; other site
395965010580	Q-loop/lid; other site
395965010581	ABC transporter signature motif; other site
395965010582	Walker B; other site
395965010583	D-loop; other site
395965010584	H-loop/switch region; other site
395965010585	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
395965010586	glycosyltransferase, MGT family; Region: MGT; TIGR01426
395965010587	active site
395965010588	TDP-binding site; other site
395965010589	acceptor substrate-binding pocket; other site
395965010590	Condensation domain; Region: Condensation; pfam00668
395965010591	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
395965010592	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
395965010593	two-component response regulator VirG; Provisional; Region: PRK13856
395965010594	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965010595	active site
395965010596	phosphorylation site [posttranslational modification]
395965010597	intermolecular recognition site; other site
395965010598	dimerization interface [polypeptide binding]; other site
395965010599	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395965010600	DNA binding site [nucleotide binding]
395965010601	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
395965010602	Cytochrome c; Region: Cytochrom_C; cl11414
395965010603	two-component VirA-like sensor kinase; Provisional; Region: PRK13837
395965010604	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
395965010605	dimer interface [polypeptide binding]; other site
395965010606	phosphorylation site [posttranslational modification]
395965010607	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
395965010608	ATP binding site [chemical binding]; other site
395965010609	Mg2+ binding site [ion binding]; other site
395965010610	G-X-G motif; other site
395965010611	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965010612	active site
395965010613	intermolecular recognition site; other site
395965010614	dimerization interface [polypeptide binding]; other site
395965010615	two-component response regulator VirG; Provisional; Region: PRK13856
395965010616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965010617	active site
395965010618	phosphorylation site [posttranslational modification]
395965010619	intermolecular recognition site; other site
395965010620	dimerization interface [polypeptide binding]; other site
395965010621	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
395965010622	DNA binding site [nucleotide binding]
395965010623	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
395965010624	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
395965010625	homodimer interface [polypeptide binding]; other site
395965010626	active site
395965010627	TDP-binding site; other site
395965010628	acceptor substrate-binding pocket; other site
395965010629	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
395965010630	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
395965010631	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
395965010632	HSP70 interaction site [polypeptide binding]; other site
395965010633	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
395965010634	substrate binding site [polypeptide binding]; other site
395965010635	dimer interface [polypeptide binding]; other site
395965010636	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
395965010637	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
395965010638	Response regulator receiver domain; Region: Response_reg; pfam00072
395965010639	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
395965010640	active site
395965010641	phosphorylation site [posttranslational modification]
395965010642	intermolecular recognition site; other site
395965010643	dimerization interface [polypeptide binding]; other site
395965010644	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
395965010645	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
395965010646	prephenate dehydratase; Provisional; Region: PRK11899
395965010647	Prephenate dehydratase; Region: PDT; pfam00800
395965010648	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
395965010649	putative L-Phe binding site [chemical binding]; other site
395965010650	Cytochrome c2 [Energy production and conversion]; Region: COG3474
395965010651	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
395965010652	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
395965010653	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
395965010654	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965010655	dimer interface [polypeptide binding]; other site
395965010656	conserved gate region; other site
395965010657	ABC-ATPase subunit interface; other site
395965010658	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
395965010659	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
395965010660	ABC-ATPase subunit interface; other site
395965010661	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
395965010662	metal binding site [ion binding]; metal-binding site
395965010663	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
395965010664	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395965010665	Walker A/P-loop; other site
395965010666	ATP binding site [chemical binding]; other site
395965010667	Q-loop/lid; other site
395965010668	ABC transporter signature motif; other site
395965010669	Walker B; other site
395965010670	D-loop; other site
395965010671	H-loop/switch region; other site
395965010672	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395965010673	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
395965010674	Walker A/P-loop; other site
395965010675	ATP binding site [chemical binding]; other site
395965010676	Q-loop/lid; other site
395965010677	ABC transporter signature motif; other site
395965010678	Walker B; other site
395965010679	D-loop; other site
395965010680	H-loop/switch region; other site
395965010681	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
395965010682	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
395965010683	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
395965010684	active site
395965010685	homotetramer interface [polypeptide binding]; other site
395965010686	trehalose synthase; Region: treS_nterm; TIGR02456
395965010687	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
395965010688	active site
395965010689	catalytic site [active]
395965010690	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
395965010691	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
395965010692	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239